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Aliases for IGF2BP1 Gene

Aliases for IGF2BP1 Gene

  • Insulin-Like Growth Factor 2 MRNA Binding Protein 1 2 3
  • CRDBP 3 4 6
  • IMP1 3 4 6
  • ZBP1 3 4 6
  • Coding Region Determinant-Binding Protein 3 4
  • IGF-II MRNA-Binding Protein 1 3 4
  • IGF2 MRNA-Binding Protein 1 3 4
  • Zipcode-Binding Protein 1 3 4
  • VICKZ Family Member 1 3 4
  • CRD-BP 3 4
  • VICKZ1 3 4
  • IMP-1 3 4
  • ZBP-1 3 4
  • Insulin-Like Growth Factor 2 MRNA-Binding Protein 1 3
  • IGF II MRNA Binding Protein 1 2

External Ids for IGF2BP1 Gene

Previous GeneCards Identifiers for IGF2BP1 Gene

  • GC17P044430
  • GC17P047074
  • GC17P042441

Summaries for IGF2BP1 Gene

Entrez Gene Summary for IGF2BP1 Gene

  • This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for IGF2BP1 Gene

IGF2BP1 (Insulin-Like Growth Factor 2 MRNA Binding Protein 1) is a Protein Coding gene. Among its related pathways are MicroRNAs in cancer and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include nucleotide binding and mRNA 3-UTR binding. An important paralog of this gene is IGF2BP2.

UniProtKB/Swiss-Prot for IGF2BP1 Gene

  • RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3-UTR, known as the zipcode. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5-UTR and 3-UTR and specifically enhances translation at the HCV IRES, but not 5-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.

Gene Wiki entry for IGF2BP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF2BP1 Gene

Genomics for IGF2BP1 Gene

Regulatory Elements for IGF2BP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IGF2BP1 Gene

Start:
48,997,412 bp from pter
End:
49,056,145 bp from pter
Size:
58,734 bases
Orientation:
Plus strand

Genomic View for IGF2BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGF2BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2BP1 Gene

Proteins for IGF2BP1 Gene

  • Protein details for IGF2BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZI8-IF2B1_HUMAN
    Recommended name:
    Insulin-like growth factor 2 mRNA-binding protein 1
    Protein Accession:
    Q9NZI8
    Secondary Accessions:
    • C9JT33

    Protein attributes for IGF2BP1 Gene

    Size:
    577 amino acids
    Molecular mass:
    63481 Da
    Quaternary structure:
    • Can form homodimers and heterodimers with IGF2BP1 and IGF2BP3. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. During HCV infection, identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts (via the KH domains) with HIV-1 GAG (via the second zinc finger motif of NC). Associates (via the RRM domains and KH domains) with HIV-1 particles. Identified in a mRNP complex, composed of at least DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with DHX9, ELAVL2, HNRNPA2B1, HNRNPC, HNRNPH1, HNRNPU, IGF2BP2, ILF2, and YBX1. Interacts with FMR1. Component of a multisubunit autoregulatory RNP complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1/UNR. Directly interacts with PABPC1. Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP. Interacts with ELAVL4 in an RNA-dependent manner. Associates with microtubules and polysomes. Interacts with AGO1 and AGO2.

    Three dimensional structures from OCA and Proteopedia for IGF2BP1 Gene

    Alternative splice isoforms for IGF2BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGF2BP1 Gene

Proteomics data for IGF2BP1 Gene at MOPED

Post-translational modifications for IGF2BP1 Gene

  • Phosphorylated. Phosphorylation may impair association with ACTB mRNA and hence abolishes translational repression (By similarity).
  • Ubiquitination at Lys20, Lys26, Lys138, Lys190, Lys213, Lys440, Lys450, Lys465, and Lys475
  • Modification sites at PhosphoSitePlus

Other Protein References for IGF2BP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IGF2BP1 (IGF2BP1)

No data available for DME Specific Peptides for IGF2BP1 Gene

Domains for IGF2BP1 Gene

Gene Families for IGF2BP1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for IGF2BP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZI8

UniProtKB/Swiss-Prot:

IF2B1_HUMAN :
  • Q9NZI8
Domain:
  • Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules. KH3 and KH4 mediate association with the cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only KH2 NES is XPO1-dependent. Both NES may be redundant, since individual in vitro mutations do not affect subcellular location of the full length protein. The 4 KH domains are important to suppress HIV-1 infectivity.
  • Contains 4 KH domains.
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM IMP/VICKZ family.
genes like me logo Genes that share domains with IGF2BP1: view

Function for IGF2BP1 Gene

Molecular function for IGF2BP1 Gene

UniProtKB/Swiss-Prot Function: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3-UTR, known as the zipcode. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5-UTR and 3-UTR and specifically enhances translation at the HCV IRES, but not 5-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.
UniProtKB/Swiss-Prot Induction: May be up-regulated in response to CTNNB1/beta-catenin activation.

Gene Ontology (GO) - Molecular Function for IGF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003729 mRNA binding IDA 17101699
GO:0003730 mRNA 3-UTR binding IDA 20080952
genes like me logo Genes that share ontologies with IGF2BP1: view
genes like me logo Genes that share phenotypes with IGF2BP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2BP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGF2BP1 Gene

Localization for IGF2BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF2BP1 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, dendrite. Cell projection, dendritic spine. Cell projection, growth cone. Cell projection, filopodium. Cell projection, axon. Note=In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription (By similarity). In the cytoplasm, localizes in cytoplasmic mRNP granules. Colocalizes with microtubules in growth cone filopodia and along neurites in neuronal cells (By similarity). Cytoplasmic colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript. In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited (By similarity). In hippocampal neurons, predominantly located within dendrites, particularly at dendritic branching points in young cells, compared to axons (By similarity). In axons, predominantly found in axonal branches and their growth cones (By similarity). In motile cells, such as migrating fibroblasts, localizes to leading edges where it colocalizes with microtubules and microfilaments and to retracting tails (By similarity). Dendritic levels are regulated by neuronal activity and glutaminergic signals: they are increased by KCl-induced depolarization, which induces rapid efflux from the cell body into dendrites, and decreased by the NMDA receptor agonist (By similarity). In motile cells, transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments (By similarity). In response to cellular stress, such as oxidative stress or heat shock, recruited to stress granules, but not to processing bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGF2BP1 Gene COMPARTMENTS Subcellular localization image for IGF2BP1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for IGF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 17289661
GO:0005829 cytosol TAS --
GO:0010494 cytoplasmic stress granule IDA 17101699
GO:0030027 lamellipodium IEA --
genes like me logo Genes that share ontologies with IGF2BP1: view

Pathways for IGF2BP1 Gene

genes like me logo Genes that share pathways with IGF2BP1: view

Gene Ontology (GO) - Biological Process for IGF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006403 RNA localization --
GO:0010467 gene expression TAS --
GO:0010610 regulation of mRNA stability involved in response to stress IMP 17101699
GO:0017148 negative regulation of translation IDA 9891060
GO:0042035 regulation of cytokine biosynthetic process IC 9891060
genes like me logo Genes that share ontologies with IGF2BP1: view

Transcripts for IGF2BP1 Gene

Unigene Clusters for IGF2BP1 Gene

Insulin-like growth factor 2 mRNA binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2BP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IGF2BP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2BP1 Gene

No ASD Table

Relevant External Links for IGF2BP1 Gene

GeneLoc Exon Structure for
IGF2BP1
ECgene alternative splicing isoforms for
IGF2BP1

Expression for IGF2BP1 Gene

mRNA expression in normal human tissues for IGF2BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGF2BP1 Gene

This gene is overexpressed in Testis (20.7) and Kidney - Cortex (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGF2BP1 Gene

SOURCE GeneReport for Unigene cluster for IGF2BP1 Gene Hs.144936

mRNA Expression by UniProt/SwissProt for IGF2BP1 Gene

Q9NZI8-IF2B1_HUMAN
Tissue specificity: Mainly expressed in the embryo, including in fetal liver, fetal lung, fetal kidney, fetal thymus (at protein level). Also expressed follicles of ovary, as well as in gonocytes of testis, spermatogonia, semen, oocytes and placenta (at protein level). Expressed in various cancers, including testis and lung cancers (at protein level), as well as kidney, prostate and trachea cancers.
genes like me logo Genes that share expressions with IGF2BP1: view

In Situ Assay Products

Orthologs for IGF2BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGF2BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGF2BP1 35
  • 99.83 (n)
  • 99.83 (a)
IGF2BP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGF2BP1 35
  • 91.05 (n)
  • 99.48 (a)
IGF2BP1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGF2BP1 35
  • 90.91 (n)
  • 99.83 (a)
IGF2BP1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igf2bp1 35
  • 89.43 (n)
  • 99.31 (a)
Igf2bp1 16
Igf2bp1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGF2BP1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGF2BP1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igf2bp1 35
  • 90.41 (n)
  • 99.65 (a)
chicken
(Gallus gallus)
Aves IGF2BP1 35
  • 82.64 (n)
  • 94.62 (a)
IGF2BP1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGF2BP1 36
  • 94 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii igf2bp1 35
  • 73.27 (n)
  • 81.42 (a)
igf2bp1 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012103 35
  • 55.95 (n)
  • 47.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta Imp 35
  • 53.28 (n)
  • 44.92 (a)
Imp 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zbp-1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4734 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for IGF2BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IGF2BP1 Gene

ENSEMBL:
Gene Tree for IGF2BP1 (if available)
TreeFam:
Gene Tree for IGF2BP1 (if available)

Paralogs for IGF2BP1 Gene

Paralogs for IGF2BP1 Gene

Selected SIMAP similar genes for IGF2BP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IGF2BP1: view

Variants for IGF2BP1 Gene

Sequence variations from dbSNP and Humsavar for IGF2BP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2969 -- 49,050,885(+) CAATG(C/T)ATATT utr-variant-3-prime
rs729003 -- 49,040,413(+) ggtgt(C/T)gccat intron-variant
rs1463761 -- 49,040,726(-) ccata(C/T)gtact intron-variant
rs1495274 -- 49,000,286(-) CATCA(C/T)CTCCC intron-variant
rs1948513 -- 48,999,195(-) CCCAC(C/G)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGF2BP1 Gene

Variant ID Type Subtype PubMed ID
nsv833472 CNV Gain 17160897
nsv510716 CNV Loss 20534489

Relevant External Links for IGF2BP1 Gene

HapMap Linkage Disequilibrium report
IGF2BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGF2BP1 Gene

Disorders for IGF2BP1 Gene

(9) Novoseek inferred disease relationships for IGF2BP1 Gene

Disease -log(P) Hits PubMed IDs
lung tumor 35.7 1
meningioma 31.2 2
colorectal cancer 28.6 3
breast carcinoma 20.4 2
sarcoma 19.3 2

Relevant External Links for IGF2BP1

Genetic Association Database (GAD)
IGF2BP1
Human Genome Epidemiology (HuGE) Navigator
IGF2BP1
genes like me logo Genes that share disorders with IGF2BP1: view

No data available for UniProtKB/Swiss-Prot for IGF2BP1 Gene

Publications for IGF2BP1 Gene

  1. The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins. (PMID: 9801297) Doyle G.A. … Ross J. (Nucleic Acids Res. 1998) 3 4 23
  2. CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signaling. (PMID: 16778892) Noubissi F.K. … Spiegelman V.S. (Nature 2006) 3 4 23
  3. Increased expression of insulin-like growth factor-II messenger RNA- binding protein 1 is associated with tumor progression in patients with lung cancer. (PMID: 17255263) Kato T. … Daigo Y. (Clin. Cancer Res. 2007) 3 4 23
  4. Insulin-like growth factor II mRNA binding protein 1 associates with Gag protein of human immunodeficiency virus type 1, and its overexpression affects virus assembly. (PMID: 18385235) Zhou Y. … Liang C. (J. Virol. 2008) 3 4 23
  5. CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183- mediated degradation. (PMID: 19647520) Elcheva I. … Spiegelman V.S. (Mol. Cell 2009) 3 4 23

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