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IGF2BP1 Gene

protein-coding   GIFtS: 60
GCID: GC17P047074

Insulin-Like Growth Factor 2 MRNA Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin-Like Growth Factor 2 MRNA Binding Protein 11 2     VICKZ12 3
CRDBP2 3 5     ZBP-12 3
IMP12 3 5     IGF-II MRNA-Binding Protein 12 3
ZBP12 3 5     IGF2 MRNA-Binding Protein 12 3
Coding Region Determinant-Binding Protein2 3     VICKZ Family Member 12 3
Zipcode-Binding Protein 12 3     IGF II MRNA Binding Protein 11
CRD-BP2 3     Insulin-Like Growth Factor 2 MRNA-Binding Protein 12
IMP-12 3     

External Ids:    HGNC: 288661   Entrez Gene: 106422   Ensembl: ENSG000001592177   OMIM: 6082885   UniProtKB: Q9NZI83   

Export aliases for IGF2BP1 gene to outside databases

Previous GC identifers: GC17P044430 GC17P042441


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGF2BP1 Gene:
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by
this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs
of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing
protein, and regulating their translation. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, May 2009)

GeneCards Summary for IGF2BP1 Gene:
IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) is a protein-coding gene. Diseases associated with IGF2BP1 include treacher collins syndrome, and dwarfism. GO annotations related to this gene include mRNA 3'-UTR binding and nucleotide binding. An important paralog of this gene is IGF2BP2.

UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8
Function: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This
transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and
location at which target transcripts encounter the translational apparatus and shields them from endonuclease
attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts
required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB
mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally
associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB
mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein
and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being
translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is
phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB
protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During
neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration,
presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May
regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By
similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA
stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA
by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and
translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame
(ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the
3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells.
Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations.
Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in
PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents
BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed
movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and
inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This
combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation,
consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence
enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization.
Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES,
but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks
the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as
assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or
heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC,
PTEN, RAPGEF2 and RPS6KA5 transcripts

Gene Wiki entry for IGF2BP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGF2BP1 gene promoter:
         USF1   MAZR   Pax-5   AP-2gamma   Zic1   USF-1   AP-2beta   Pax-4a   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGF2BP1 promoter sequence
   Search Chromatin IP Primers for IGF2BP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGF2BP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

IGF2BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF2BP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P047074:  view genomic region     (about GC identifiers)

Start:
47,074,774 bp from pter      End:
47,133,507 bp from pter
Size:
58,734 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8 (See protein sequence)
Recommended Name: Insulin-like growth factor 2 mRNA-binding protein 1  
Size: 577 amino acids; 63481 Da
Subunit: Can form homodimers and heterodimers with IGF2BP1 and IGF2BP3. Component of the coding region determinant
(CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. During HCV infection, identified in
a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon.
Interacts (via the KH domains) with HIV-1 GAG (via the second zinc finger motif of NC). Associates (via the RRM
domains and KH domains) with HIV-1 particles. Identified in a mRNP complex, composed of at least DHX9, DDX3X,
ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a
IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with DHX9, ELAVL2, HNRNPA2B1,
HNRNPC, HNRNPH1, HNRNPU, IGF2BP2, ILF2, and YBX1. Interacts with FMR1. Component of a multisubunit autoregulatory
RNP complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1/UNR. Directly interacts with PABPC1. Component
of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP. Interacts with ELAVL4 in an RNA-dependent
manner. Associates with microtubules and polysomes. Interacts with AGO1 and AGO2
1 PDB 3D structure from and Proteopedia for IGF2BP1:
3KRM (3D)    
Secondary accessions: C9JT33
Alternative splicing: 2 isoforms:  Q9NZI8-1   Q9NZI8-2   

Explore the universe of human proteins at neXtProt for IGF2BP1: NX_Q9NZI8

Explore proteomics data for IGF2BP1 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation may impair association with ACTB mRNA and hence abolishes translational repression
    (By similarity)1
  • Ubiquitination2 at Lys20, Lys26, Lys138, Lys190, Lys213, Lys440, Lys450, Lys465, Lys475
  • Modification sites at PhosphoSitePlus

  • See IGF2BP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153895.1  NP_006537.3  

    ENSEMBL proteins: 
     ENSP00000290341   ENSP00000389135  
    Reactome Protein details: Q9NZI8

    IGF2BP1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR004087 KH_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR004088 KH_dom_type_1
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZI8

    ProtoNet protein and cluster: Q9NZI8

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB004087 KH domain


    UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8
    Domain: Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. KH1 and
    KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be
    essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and
    heterooligomerization and for localization to stress granules. KH3 and KH4 mediate association with the
    cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only
    KH2 NES is XPO1-dependent. Both NES may be redundant, since individual in vitro mutations do not affect
    subcellular location of the full length protein. The 4 KH domains are important to suppress HIV-1 infectivity
    Similarity: Belongs to the RRM IMP/VICKZ family
    Similarity: Contains 4 KH domains
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    IGF2BP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF2B1_HUMAN, Q9NZI8
    Function: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This
    transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and
    location at which target transcripts encounter the translational apparatus and shields them from endonuclease
    attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts
    required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB
    mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally
    associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB
    mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein
    and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being
    translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is
    phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB
    protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During
    neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration,
    presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May
    regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By
    similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA
    stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA
    by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and
    translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame
    (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the
    3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells.
    Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations.
    Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in
    PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents
    BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed
    movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and
    inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This
    combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation,
    consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence
    enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization.
    Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES,
    but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks
    the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as
    assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or
    heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC,
    PTEN, RAPGEF2 and RPS6KA5 transcripts
    Induction: May be up-regulated in response to CTNNB1/beta-catenin activation (PubMed:16778892)

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003729mRNA binding IDA17101699
    GO:0003730mRNA 3'-UTR binding IDA--
         
    IGF2BP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IGF2BP1:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Igf2bp1) (see all 17):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  renal/urinary system 

    IGF2BP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGF2BP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGF2BP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGF2BP1

    miRNA
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    miRTarBase miRNAs that target IGF2BP1:
    hsa-mir-877-3p (MIRT036910), hsa-let-7b-5p (MIRT001621), hsa-mir-320a (MIRT044393), hsa-mir-378a-3p (MIRT019663), hsa-mir-99b-5p (MIRT044181), hsa-mir-484 (MIRT042104), hsa-let-7f-5p (MIRT051402), hsa-let-7g-5p (MIRT003831), hsa-mir-1229-3p (MIRT036388), hsa-mir-615-3p (MIRT039632), hsa-mir-196a-5p (MIRT026098), hsa-let-7d-5p (MIRT032186)

    Block miRNA regulation of human, mouse, rat IGF2BP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGF2BP1 (see all 201):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-193a-3p hsa-miR-106a hsa-miR-1260b hsa-miR-3074-3p hsa-miR-519a hsa-miR-3916
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    GenScript: all cDNA clones in your preferred vector (see all 2): IGF2BP1 (NM_006546)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IF2B1_HUMAN, Q9NZI8: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell
    projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Cell projection, growth
    cone. Cell projection, filopodium (By similarity). Cell projection, axon (By similarity). Note=In the nucleus,
    located in discrete foci, coinciding with the sites of ACTB transcription (By similarity). In the cytoplasm,
    localizes in cytoplasmic mRNP granules. Colocalizes with microtubules in growth cone filopodia and along neurites
    in neuronal cells (By similarity). Cytoplasmic colocalization with ACTB mRNA is partially lost at the cell
    periphery, suggesting release of the transcript. In neuronal processes, exhibits fast retrograde and anterograde
    movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited (By
    similarity). In hippocampal neurons, predominantly located within dendrites, particularly at dendritic branching
    points in young cells, compared to axons (By similarity). In axons, predominantly found in axonal branches and
    their growth cones (By similarity). In motile cells, such as migrating fibroblasts, localizes to leading edges
    where it colocalizes with microtubules and microfilaments and to retracting tails (By similarity). Dendritic
    levels are regulated by neuronal activity and glutaminergic signals: they are increased by KCl-induced
    depolarization, which induces rapid efflux from the cell body into dendrites, and decreased by the NMDA receptor
    agonist (By similarity). In motile cells, transported towards the leading edge into the cortical region of the
    lamellipodia where it is connected to microfilaments (By similarity). In response to cellular stress, such as
    oxidative stress or heat shock, recruited to stress granules, but not to processing bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4
    peroxisome2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA17289661
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ----
    GO:0010494cytoplasmic stress granule IDA17101699

    IGF2BP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGF2BP1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Gene Expression0.40
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3Translational Control
    Translational Control
    4Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    5MicroRNAs in cancer
    MicroRNAs in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for IGF2BP1
        Wnt / Hedgehog / Notch
    Translational Control
    Cytoskeletal Signaling

    2 BioSystems Pathways for IGF2BP1
        BDNF signaling pathway
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    1 Reactome Pathway for IGF2BP1
        Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA


    1 Kegg Pathway  (Kegg details for IGF2BP1):
        MicroRNAs in cancer


    IGF2BP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGF2BP1
    Interactions:

        GeneGlobe Interaction Network for IGF2BP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IGF2BP1 (Q9NZI82, 3 ENSP000002903414) via UniProtKB, MINT, STRING, and/or I2D (see all 335)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LYARQ9NX582, 3MINT-6488590 I2D: score=1 
    YWHAEP622582, 3MINT-8395092 I2D: score=1 
    DHX9Q082112, ENSP000003565204MINT-6489539 MINT-6488590 MINT-8395092 MINT-6488791 STRING: ENSP00000356520
    HNRNPUQ008392, ENSP000002831794MINT-6489539 MINT-6488590 MINT-6488791 STRING: ENSP00000283179
    UBCP0CG482, 3, ENSP000003448184MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006403RNA localization ----
    GO:0010467gene expression TAS--
    GO:0010610regulation of mRNA stability involved in response to stress IMP17101699
    GO:0017148negative regulation of translation IDA9891060
    GO:0042035regulation of cytokine biosynthetic process IC9891060

    IGF2BP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IGF2BP1 gene (2 alternative transcripts): 
    NM_001160423.1  NM_006546.3  

    Unigene Cluster for IGF2BP1:

    Insulin-like growth factor 2 mRNA binding protein 1
    Hs.144936  [show with all ESTs]
    Unigene Representative Sequence: NM_006546
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290341(uc002iom.3 uc010dbj.3) ENST00000510023 ENST00000431824
    ENST00000515586 ENST00000499130 ENST00000505562
    miRNA
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    Additional mRNA sequence: 

    AF117106.1 AF198254.1 AK022617.1 AK022784.1 AK074915.1 AK095573.1 AK313229.1 DQ227344.1 

    7 DOTS entries:

    DT.413609  DT.91729612  DT.70101082  DT.91866337  DT.100696736  DT.102826022  DT.75101729 

    Selected AceView cDNA sequences (see all 176):

    AA991688 AK074915 BQ651665 AI335528 BF984962 AI655596 AA906313 BQ882965 
    AK022617 AI337147 AI989990 BE909874 BX089676 AI671622 AF117106 H64283 
    BQ228371 BE466712 BE466868 CB146278 AU130190 BM928196 BQ225582 AW196265 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGF2BP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCACCCCT
    IGF2BP1 Expression
    About this image


    IGF2BP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
             Islets of Langerhans
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    IGF2BP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGF2BP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.144936

    UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8
    Tissue specificity: Mainly expressed in the embryo, including in fetal liver, fetal lung, fetal kidney, fetal
    thymus (at protein level). Also expressed follicles of ovary, as well as in gonocytes of testis, spermatogonia,
    semen, oocytes and placenta (at protein level). Expressed in various cancers, including testis and lung cancers
    (at protein level), as well as kidney, prostate and trachea cancers

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IGF2BP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igf2bp11 , 5 insulin-like growth factor 2 mRNA binding protein 11, 5 89.43(n)1
    99.31(a)1
      11 (59.08 cM)5
    1404861  NM_009951.41  NP_034081.11 
     959571635 
    chicken
    (Gallus gallus)
    Aves IGF2BP11 insulin-like growth factor 2 mRNA binding protein 1 82.64(n)
    94.62(a)
      395953  NM_205071.1  NP_990402.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGF2BP16
    insulin-like growth factor 2 mRNA binding protein ...
    94(a)
    1 ↔ 1
    6(76016809-76095415)
    zebrafish
    (Danio rerio)
    Actinopterygii igf2bp11 insulin-like growth factor 2 mRNA binding protein 1 73.27(n)
    81.42(a)
      558182  NM_001076559.1  NP_001070027.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Imp1 IGF-II mRNA-binding protein 53.28(n)
    44.92(a)
      32009  NM_001042803.3  NP_001036268.2 
    worm
    (Caenorhabditis elegans)
    Secernentea zbp-16
    Protein M88.5, isoform c
    16(a)
    1 → many
    III(4553646-4560350) WBGene00010908


    ENSEMBL Gene Tree for IGF2BP1 (if available)
    TreeFam Gene Tree for IGF2BP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGF2BP1 gene
    IGF2BP22  IGF2BP32  
    3 SIMAP similar genes for IGF2BP1 using alignment to 3 protein entries:     IF2B1_HUMAN (see all proteins):
    IGF2BP3    IGF2BP2    PCBP2

    IGF2BP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGF2BP1 (see all 1157)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10180571,2
    C,H--42439970(-) TCTATC/ATCCTC 2 -- us2k113Minor allele frequency- A:0.00MN NA WA CSA EA 444
    rs3694088851,2
    C--47076449(+) TGGTA-/TTTTTT 2 -- int10--------
    rs58207421,2
    C--47076718(+) AAAAAA/-TAAAT 2 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs114553551,2
    C--47078302(+) AAAAA-/ATCTGT 2 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs711445521,2
    C--47086739(+) GAAACTT/-TTAGG 2 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs561176661,2
    C--47089211(+) ATTTT-/TCCTAT 2 -- int10--------
    rs680745341,2
    C--47089266(+) TTTTT-/T/TT  
            
    TTTTT
    2 -- int10--------
    rs352976861,2
    C,F--47090588(+) ACCCC-/CAAA  
            
    CAAAT
    2 -- int13Minor allele frequency- CAAA:0.33NA CSA 6
    rs80745971,2
    C--47097312(+) tatatA/Ttatat 2 -- int11Minor allele frequency- T:0.00NA 2
    rs1999006661,2
    --47097318(+) TATAT-/ACAC  
            
    ACACA
    2 -- int10--------

    HapMap Linkage Disequilibrium report for IGF2BP1 (47074774 - 47133507 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IGF2BP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510716CNV Loss20534489
    nsv833472CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608288    OMIM disorders: --

    Selected diseases for IGF2BP1 (see all 31):    
    About MalaCards
    treacher collins syndrome    dwarfism    lactic acidosis    testicular cancer
    meningioma    myopathy    hiv-1    insulin resistance
    colorectal cancer    hepatitis c virus    choroiditis    hepatitis c
    atherosclerosis    sarcoma    tonsillitis    lung cancer
    breast cancer    ovarian cancer    hepatocellular carcinoma    melanoma


    IGF2BP1 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for IGF2BP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung tumor 35.7 1 14729626 (1)
    meningioma 31.2 2 15159028 (1), 12894594 (1)
    colorectal cancer 28.6 3 11641779 (1), 16778892 (1), 20027638 (1)
    breast carcinoma 20.4 3 12532419 (1), 12894594 (1)
    sarcoma 19.3 2 15159028 (1), 12894594 (1)
    tumors 14.3 25 12532419 (7), 15159028 (3), 12894594 (3), 11641779 (2) (see all 8)
    breast cancer 2.2 3 11641779 (1), 10850408 (1)
    leukemia 1.34 2 15355996 (1)
    cancer 0 9 11641779 (2), 17255263 (2), 9801297 (1), 16778892 (1)

    Genetic Association Database (GAD): IGF2BP1
    Human Genome Epidemiology (HuGE) Navigator: IGF2BP1 (4 documents)

    Export disorders for IGF2BP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGF2BP1 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with IGF2BP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. (PubMed id 9891060)1, 2, 3 Nielsen J.... Nielsen F.C. (Mol. Cell. Biol. 1999)
    2. Increased expression of insulin-like growth factor-II messenger RNA- binding protein 1 is associated with tumor progression in patients with lung cancer. (PubMed id 17255263)1, 2, 9 Kato T.... Daigo Y. (Clin. Cancer Res. 2007)
    3. CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signaling. (PubMed id 16778892)1, 2, 9 Noubissi F.K.... Spiegelman V.S. (Nature 2006)
    4. The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins. (PubMed id 9801297)1, 2, 9 Doyle G.A....Ross J. (Nucleic Acids Res. 1998)
    5. Insulin-like growth factor II mRNA binding protein 1 associates with Gag protein of human immunodeficiency virus type 1, and its overexpression affects virus assembly. (PubMed id 18385235)1, 2, 9 Zhou Y.... Liang C. (J. Virol. 2008)
    6. CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183- mediated degradation. (PubMed id 19647520)1, 2, 9 Elcheva I.... Spiegelman V.S. (Mol. Cell 2009)
    7. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303)1, 2, 9 Weidensdorfer D.... Huettelmaiery S. (RNA 2009)
    8. IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. (PubMed id 22279049)1, 2 StAPhr N....HA1ttelmaier S. (amp 2012)
    9. IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes. (PubMed id 20627640)1, 4 Rodriguez S....Day I.N. (amp 2010)
    10. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10642 HGNC: 28866 AceView: IMP-1 Ensembl:ENSG00000159217 euGenes: HUgn10642
    ECgene: IGF2BP1 Kegg: 10642 H-InvDB: IGF2BP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IGF2BP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGF2BP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGF2BP1 gene:
    Search GeneIP for patents involving IGF2BP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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