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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGF2BP1 Gene

protein-coding   GIFtS: 60
GCID: GC17P047074

Insulin-Like Growth Factor 2 MRNA Binding Protein 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like Growth Factor 2 MRNA Binding Protein 11 2     ZBP-12 3
CRDBP2 3 5     IGF-II MRNA-Binding Protein 12 3
ZBP12 3 5     IGF2 MRNA-Binding Protein 12 3
Coding Region Determinant-Binding Protein2 3     VICKZ Family Member 12 3
Zipcode-Binding Protein 12 3     IMP12 5
CRD-BP2 3     IGF II MRNA Binding Protein 11
IMP-12 3     Insulin-Like Growth Factor 2 MRNA-Binding Protein 12
VICKZ12 3     Zip Code-Binding Protein 13

External Ids:    HGNC: 288661   Entrez Gene: 106422   Ensembl: ENSG000001592177   OMIM: 6082885   UniProtKB: Q9NZI83   

Export aliases for IGF2BP1 gene to outside databases

Previous GC identifers: GC17P044430 GC17P042441


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGF2BP1 Gene:
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by
this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs
of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing
protein, and regulating their translation. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, May 2009)

GeneCards Summary for IGF2BP1 Gene: 
IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) is a protein-coding gene. Diseases associated with IGF2BP1 include dwarfism, and testicular cancer, and among its related super-pathways are Generic Transcription Pathway. GO annotations related to this gene include mRNA 3'-UTR binding and nucleotide binding. An important paralog of this gene is IGF2BP2.

UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8
Function: RNA-binding factor that affects mRNA nuclear export, localization, stability and translation. Component
of the CRD-mediated complex that promotes MYC mRNA stabilization. Regulates mRNA stability during the integrated
cellular stress response (ISR) in stress granules (SGs). Stabilizes the BTRC/FBW1A mRNA from degradation by
disrupting miRNA-dependent interaction with AGO2. Identified in a HCV IRES-mediated translation complex, that
enhances translation at the Hepatitis C virus (HCV) RNA-replicon via the internal ribosome entry site (IRES), but
does not affect 5'cap-dependent translation. Acts as a HIV-1 retrovirus restriction factor that reduces HIV-1
assembly by inhibiting viral RNA packaging, assembly and processing of HIV-1 GAG protein on cellular membranes.
Binds to mRNAs in stress granules (SGs). Binds to the stem-loop IV of the 5'-UTR and to the variable region and
the poly(U-C) motif of the 3'-UTR of the HCV RNA-replicon. Binds to the 5'-UTR of the insulin-like growth factor
2 (IGF2) mRNA and regulates its subcellular localization and translation. Binds both to the coding region mRNA
stability determinant (CRD) and to AU-rich sequences in the 3'-UTR of the MYC and CD44 mRNAs and stabilizes these
mRNAs. Binds to the fourth and fifth exons of the oncofetal H19 and neuron-specific TAU mRNAs and regulates their
localizations. Binds to the adenine-rich autoregulatory sequence (ARS) 5'-UTR of the PABPC1 mRNA and is involved
in its translational repression. The RNA-binding activity to ARS is stimulated by PABPC1. Binds to the coding
sequence region of BTRC/FBW1A mRNA and mediates stabilization of BTRC/FBW1A and MYC mRNAs in response to
beta-catenin signaling. Binding to RNA employs a cooperative, sequential mechanism of homo- or
heterodimerisation. Also involved in growth or survival of lung-cancer cells. Protects the MYC and MDR-1 mRNAs
from cleavage by a endoribonuclease, thus prolonging their stabilities (By similarity). Binds to the 3'-UTR
axonal localization signal (ALS) of TAU mRNA (By similarity). Binds to a conserved 54-nucleotide element in the
3'-UTR of the beta actin mRNA known as the 'zipcode' (By similarity). Promotes translocation of the beta-actin
mRNA to dendrites (By similarity). May act as a regulator of mRNA transport to activated synapses in response to
synaptic activity (By similarity)

Gene Wiki entry for IGF2BP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGF2BP1 gene promoter:
         USF1   MAZR   Pax-5   AP-2gamma   Zic1   USF-1   AP-2beta   Pax-4a   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGF2BP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGF2BP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGF2BP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

IGF2BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF2BP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P047074:  view genomic region     (about GC identifiers)

Start:
47,074,774 bp from pter      End:
47,133,507 bp from pter
Size:
58,734 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8 (See protein sequence)
Recommended Name: Insulin-like growth factor 2 mRNA-binding protein 1  
Size: 577 amino acids; 63481 Da
Subunit: Can form homodimers and heterodimers with IGF2BP1 or IGF2BP3. Component of the coding region determinant
(CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a HCV IRES-mediated
translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts (via the KH
domains) with HIV-1 GAG (via the second zinc finger motif of NC). Associates (via the RRM domains and KH domains)
with HIV-1 particles. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1,
ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least
composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8,
IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2,
YBX1 and untranslated mRNAs. Interacts with DHX9, ELAVL2, HNRNPA2B1, HNRNPC, HNRNPH1, HNRNPU, IGF2BP2, IGF2BP3,
ILF2, PABPC1 and YBX1. Found in a RNP granule complex with FMR1. Interacts with FMR1. Component of a multi
subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts
through the third and fourth KH domains with PABPC1 in a RNA-independent manner. Component of a TAU mRNP complex,
at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity). Interacts with ELAVL4 in a RNA-dependent manner
(By similarity). Associates with microtubules and polysomes (By similarity). Interacts with AGO1 and AGO2
Subcellular location: Nucleus. Cytoplasm. Cell projection, lamellipodium. Cell projection, dendrite (By
similarity). Cell projection, dendritic spine (By similarity). Note=Localized in cytoplasmic mRNP granules
containing untranslated mRNAs. Targeted to stress granules (SGs), but not processing bodies (PBs), during
cellular stress. Colocalizes with G3BP1 and TIAL1 in SGs. Colocalizes with HIV-1 GAG at the cell edges. Found in
lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic
localization is cell specific and regulated by cell contact and growth. Colocalized with H19 RNA at lamellipodia.
Colocalized with CD44 mRNA in RNP granules. Nuclear export is mediated by XPO1/CRM1. In motile cells, is
transported towards the leading edge into the cortical region of the lamellipodia where it is connected to
microfilaments (By similarity). Present in the form of granules and into F-actin-rich protrusion of dendrites,
spines and subsynaptic sites (By similarity). Colocalizes with beta-actin mRNA in dendrites and spines (By
similarity). Exhibited rapid, bidirectional movements in dendrites and spines (By similarity). Neuronal
depolarization by KCl induces its rapid efflux from the cell body into dendrites (By similarity)
1 PDB 3D structure from and Proteopedia for IGF2BP1:
3KRM (3D)    
Secondary accessions: C9JT33
Alternative splicing: 2 isoforms:  Q9NZI8-1   Q9NZI8-2   

Explore the universe of human proteins at neXtProt for IGF2BP1: NX_Q9NZI8

Explore proteomics data for IGF2BP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation may influence mRNA translation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZI8

  • IGF2BP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGF2BP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001153895.1  NP_006537.3  

    ENSEMBL proteins: 
     ENSP00000290341   ENSP00000389135  
    Reactome Protein details: Q9NZI8
    Human Recombinant Protein Products for IGF2BP1: 
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    Novus Biologicals IGF2BP1 Lysate
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for IGF2BP1 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    IGF2BP1 for ontologies           About GeneDecksing



    IGF2BP1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for IGF2BP1 
    Cloud-Clone Corp. CLIAs for IGF2BP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR004087 KH_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR004088 KH_dom_type_1
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZI8

    ProtoNet protein and cluster: Q9NZI8

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB004087 KH domain


    UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8
    Domain: The third and fourth KH domains encompass the protein dimerization motif and are necessary and sufficient
    for RNA binding. The four KH domains are important for granule formation and SGs targeting. Contains two nuclear
    export signals, situated within the second and fourth KH domains. The four KH domains are important to suppress
    HIV-1 infectivity
    Similarity: Belongs to the RRM IMP/VICKZ family
    Similarity: Contains 4 KH domains
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    IGF2BP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF2B1_HUMAN, Q9NZI8
    Function: RNA-binding factor that affects mRNA nuclear export, localization, stability and translation. Component
    of the CRD-mediated complex that promotes MYC mRNA stabilization. Regulates mRNA stability during the integrated
    cellular stress response (ISR) in stress granules (SGs). Stabilizes the BTRC/FBW1A mRNA from degradation by
    disrupting miRNA-dependent interaction with AGO2. Identified in a HCV IRES-mediated translation complex, that
    enhances translation at the Hepatitis C virus (HCV) RNA-replicon via the internal ribosome entry site (IRES), but
    does not affect 5'cap-dependent translation. Acts as a HIV-1 retrovirus restriction factor that reduces HIV-1
    assembly by inhibiting viral RNA packaging, assembly and processing of HIV-1 GAG protein on cellular membranes.
    Binds to mRNAs in stress granules (SGs). Binds to the stem-loop IV of the 5'-UTR and to the variable region and
    the poly(U-C) motif of the 3'-UTR of the HCV RNA-replicon. Binds to the 5'-UTR of the insulin-like growth factor
    2 (IGF2) mRNA and regulates its subcellular localization and translation. Binds both to the coding region mRNA
    stability determinant (CRD) and to AU-rich sequences in the 3'-UTR of the MYC and CD44 mRNAs and stabilizes these
    mRNAs. Binds to the fourth and fifth exons of the oncofetal H19 and neuron-specific TAU mRNAs and regulates their
    localizations. Binds to the adenine-rich autoregulatory sequence (ARS) 5'-UTR of the PABPC1 mRNA and is involved
    in its translational repression. The RNA-binding activity to ARS is stimulated by PABPC1. Binds to the coding
    sequence region of BTRC/FBW1A mRNA and mediates stabilization of BTRC/FBW1A and MYC mRNAs in response to
    beta-catenin signaling. Binding to RNA employs a cooperative, sequential mechanism of homo- or
    heterodimerisation. Also involved in growth or survival of lung-cancer cells. Protects the MYC and MDR-1 mRNAs
    from cleavage by a endoribonuclease, thus prolonging their stabilities (By similarity). Binds to the 3'-UTR
    axonal localization signal (ALS) of TAU mRNA (By similarity). Binds to a conserved 54-nucleotide element in the
    3'-UTR of the beta actin mRNA known as the 'zipcode' (By similarity). Promotes translocation of the beta-actin
    mRNA to dendrites (By similarity). May act as a regulator of mRNA transport to activated synapses in response to
    synaptic activity (By similarity)
    Induction: Up-regulated in response to beta-catenin activation

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003729mRNA binding IDA17101699
    GO:0003730mRNA 3'-UTR binding IDA--
         
    IGF2BP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IGF2BP1:
     Increased gamma-H2AX phosphory 

         15/16 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Igf2bp1) (see all 16):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  renal/urinary system 

    IGF2BP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGF2BP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGF2BP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGF2BP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGF2BP1 

    miRNA
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    miRTarBase miRNAs that target IGF2BP1:
    hsa-let-7b (MIRT001621), hsa-let-7g (MIRT003831)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGF2BP1
    8/201 QIAGEN miScript miRNA Assays for microRNAs that regulate IGF2BP1 (see all 201):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-193a-3p hsa-miR-106a hsa-miR-1260b hsa-miR-3074-3p hsa-miR-519a hsa-miR-3916
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): IGF2BP1 (NM_006546)
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGF2BP1 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    4MicroRNAs in cancer
    MicroRNAs in cancer
    5Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for IGF2BP1
        Wnt / Hedgehog / Notch
    Translational Control
    Cytoskeletal Signaling

    2 BioSystems Pathways for IGF2BP1
        BDNF signaling pathway
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    2        Reactome Pathways for IGF2BP1
        Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
    Gene Expression


    1         Kegg Pathway  (Kegg details for IGF2BP1):
        MicroRNAs in cancer


    IGF2BP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGF2BP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/334 Interacting proteins for IGF2BP1 (Q9NZI82, 3 ENSP000002903414) via UniProtKB, MINT, STRING, and/or I2D (see all 334)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LYARQ9NX582, 3MINT-6488590 I2D: score=1 
    YWHAEP622582, 3MINT-8395092 I2D: score=1 
    DHX9Q082112, ENSP000003565204MINT-6489539 MINT-6488590 MINT-8395092 MINT-6488791 STRING: ENSP00000356520
    HNRNPUQ008392, ENSP000002831794MINT-6489539 MINT-6488590 MINT-6488791 STRING: ENSP00000283179
    UBCP0CG482, 3, ENSP000003448184MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006403RNA localization ----
    GO:0010467gene expression TAS--
    GO:0010610regulation of mRNA stability involved in response to stress IMP17101699
    GO:0017148negative regulation of translation IDA9891060
    GO:0042035regulation of cytokine biosynthetic process IC9891060

    IGF2BP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about IGF2BP1 / IF2B1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGF2BP1 gene (2 alternative transcripts): 
    NM_001160423.1  NM_006546.3  

    Unigene Cluster for IGF2BP1:

    Insulin-like growth factor 2 mRNA binding protein 1
    Hs.144936  [show with all ESTs]
    Unigene Representative Sequence: NM_006546
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290341(uc002iom.3 uc010dbj.3) ENST00000510023 ENST00000431824
    ENST00000515586 ENST00000499130 ENST00000505562
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF117106.1 AF198254.1 AK022617.1 AK022784.1 AK074915.1 AK095573.1 AK313229.1 DQ227344.1 

    7 DOTS entries:

    DT.413609  DT.91729612  DT.70101082  DT.91866337  DT.100696736  DT.102826022  DT.75101729 

    24/176 AceView cDNA sequences (see all 176):

    BE466868 AI338539 AI860521 AK074915 AU124935 BF984962 BQ882965 BG825401 
    BE909874 AW196265 AK022617 AI655596 CB146278 AF117106 BQ651665 AI671622 
    BX089676 CR624172 AU130190 BM928196 AI337147 BQ225582 BE466712 AI989990 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGF2BP1 expression in normal human tissues (normalized intensities)      IGF2BP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCACCCCT
    IGF2BP1 Expression
    About this image


    IGF2BP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/42 selected tissues (see all 42) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See IGF2BP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGF2BP1

    SOURCE GeneReport for Unigene cluster: Hs.144936

    UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8
    Tissue specificity: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal
    follicles of ovary, gonocytes of testis, oocytes, spermatogonia and semen (at protein level). Expressed in
    testicular and lung cancer (at protein level). Expressed in kidney, prostate, trachea, testis and lung cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IGF2BP1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igf2bp11 , 5 insulin-like growth factor 2 mRNA binding protein 11, 5 89.43(n)1
    99.31(a)1
      11 (59.08 cM)5
    1404861  NM_009951.41  NP_034081.11 
     959571635 
    chicken
    (Gallus gallus)
    Aves IGF2BP11 insulin-like growth factor 2 mRNA binding protein 1 82.64(n)
    94.62(a)
      395953  NM_205071.1  NP_990402.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGF2BP16
    Uncharacterized protein
    94(a)
    1 ↔ 1
    6(76016809-76095415)
    zebrafish
    (Danio rerio)
    Actinopterygii igf2bp11 insulin-like growth factor 2 mRNA binding protein 1 73.27(n)
    81.42(a)
      558182  NM_001076559.1  NP_001070027.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Imp1 IGF-II mRNA-binding protein 52.2(n)
    44.23(a)
      32009  NM_001042803.2  NP_001036268.2 
    worm
    (Caenorhabditis elegans)
    Secernentea M88.56
    Protein M88.5, isoform a
    16(a)
    1 → many
    III(4553646-4559926)


    ENSEMBL Gene Tree for IGF2BP1 (if available)
    TreeFam Gene Tree for IGF2BP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGF2BP1 gene
    IGF2BP22  IGF2BP32  
    3 SIMAP similar genes for IGF2BP1 using alignment to 3 protein entries:     IF2B1_HUMAN (see all proteins):
    IGF2BP3    IGF2BP2    PCBP2

    IGF2BP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1157 SNPs in IGF2BP1 are shown (see all 1157)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10180571,2
    C,H--42439970(-) TCTATC/ATCCTC 2 -- us2k113Minor allele frequency- A:0.00MN NA WA CSA EA 444
    rs3694088851,2
    C--47076449(+) TGGTA-/TTTTTT 2 -- int10--------
    rs58207421,2
    C--47076718(+) AAAAAA/-TAAAT 2 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs114553551,2
    C--47078302(+) AAAAA-/ATCTGT 2 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs711445521,2
    C--47086739(+) GAAACTT/-TTAGG 2 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs561176661,2
    C--47089211(+) ATTTT-/TCCTAT 2 -- int10--------
    rs680745341,2
    C--47089266(+) TTTTT-/T/TT  
            
    TTTTT
    2 -- int10--------
    rs352976861,2
    C,F--47090588(+) ACCCC-/CAAA  
            
    CAAAT
    2 -- int13Minor allele frequency- CAAA:0.33NA CSA 6
    rs80745971,2
    C--47097312(+) tatatA/Ttatat 2 -- int11Minor allele frequency- T:0.00NA 2
    rs1999006661,2
    --47097318(+) TATAT-/ACAC  
            
    ACACA
    2 -- int10--------

    HapMap Linkage Disequilibrium report for IGF2BP1 (47074774 - 47133507 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IGF2BP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510716CNV Loss20534489
    nsv833472CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608288    OMIM disorders: --

    19 diseases for IGF2BP1:    About MalaCards
    dwarfism    testicular cancer    lactic acidosis    meningioma
    insulin resistance    myopathy    colorectal cancer    atherosclerosis
    hepatitis c    lung cancer    sarcoma    ovarian cancer
    breast cancer    hepatocellular carcinoma    melanoma    hepatitis
    prostatitis    leukemia    neuronitis


    IGF2BP1 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for IGF2BP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung tumor 35.7 1 14729626 (1)
    meningioma 31.2 2 15159028 (1), 12894594 (1)
    colorectal cancer 28.6 3 11641779 (1), 16778892 (1), 20027638 (1)
    breast carcinoma 20.4 3 12532419 (1), 12894594 (1)
    sarcoma 19.3 2 15159028 (1), 12894594 (1)
    tumors 14.3 25 12532419 (7), 15159028 (3), 12894594 (3), 11641779 (2) (see all 8)
    breast cancer 2.2 3 11641779 (1), 10850408 (1)
    leukemia 1.34 2 15355996 (1)
    cancer 0 9 11641779 (2), 17255263 (2), 9801297 (1), 16778892 (1)

    Genetic Association Database (GAD): IGF2BP1
    Human Genome Epidemiology (HuGE) Navigator: IGF2BP1 (4 documents)

    Export disorders for IGF2BP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGF2BP1 gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with IGF2BP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. (PubMed id 9891060)1, 2, 3 Nielsen J.... Nielsen F.C. (1999)
    2. Increased expression of insulin-like growth factor-II messenger RNA- binding protein 1 is associated with tumor progression in patients with lung cancer. (PubMed id 17255263)1, 2, 9 Kato T.... Daigo Y. (2007)
    3. CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signaling. (PubMed id 16778892)1, 2, 9 Noubissi F.K.... Spiegelman V.S. (2006)
    4. The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins. (PubMed id 9801297)1, 2, 9 Doyle G.A....Ross J. (1998)
    5. Insulin-like growth factor II mRNA binding protein 1 associates with Gag protein of human immunodeficiency virus type 1, and its overexpression affects virus assembly. (PubMed id 18385235)1, 2, 9 Zhou Y.... Liang C. (2008)
    6. Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant. (PubMed id 12024010)1, 2, 9 Lemm I. and Ross J. (2002)
    7. CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183- mediated degradation. (PubMed id 19647520)1, 2, 9 Elcheva I.... Spiegelman V.S. (2009)
    8. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303)1, 2, 9 Weidensdorfer D....HA1ttelmaier S. (2009)
    9. IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes. (PubMed id 20627640)1, 4 Rodriguez S....Day I.N. (2010)
    10. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10642 HGNC: 28866 AceView: IMP-1 Ensembl:ENSG00000159217 euGenes: HUgn10642
    ECgene: IGF2BP1 Kegg: 10642 H-InvDB: IGF2BP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGF2BP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGF2BP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGF2BP1 gene:
    Search GeneIP for patents involving IGF2BP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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