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Aliases for IGF2BP1 Gene

Aliases for IGF2BP1 Gene

  • Insulin Like Growth Factor 2 MRNA Binding Protein 1 2 3 5
  • Coding Region Determinant-Binding Protein 3 4
  • IGF-II MRNA-Binding Protein 1 3 4
  • IGF2 MRNA-Binding Protein 1 3 4
  • Zipcode-Binding Protein 1 3 4
  • VICKZ Family Member 1 3 4
  • CRD-BP 3 4
  • VICKZ1 3 4
  • IMP-1 3 4
  • CRDBP 3 4
  • ZBP-1 3 4
  • IMP1 3 4
  • ZBP1 3 4
  • Insulin-Like Growth Factor 2 MRNA Binding Protein 1 DeltaN CRDBP 3
  • Insulin-Like Growth Factor 2 MRNA Binding Protein 1 2
  • Insulin-Like Growth Factor 2 MRNA-Binding Protein 1 3
  • IGF II MRNA Binding Protein 1 2

External Ids for IGF2BP1 Gene

Previous GeneCards Identifiers for IGF2BP1 Gene

  • GC17P044430
  • GC17P047074
  • GC17P042441

Summaries for IGF2BP1 Gene

Entrez Gene Summary for IGF2BP1 Gene

  • This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for IGF2BP1 Gene

IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) is a Protein Coding gene. Diseases associated with IGF2BP1 include Hiv-1. Among its related pathways are Translational Control and RET signaling. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is IGF2BP3.

UniProtKB/Swiss-Prot for IGF2BP1 Gene

  • RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3-UTR, known as the zipcode. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5-UTR and 3-UTR and specifically enhances translation at the HCV IRES, but not 5-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.

Gene Wiki entry for IGF2BP1 Gene

Additional gene information for IGF2BP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF2BP1 Gene

Genomics for IGF2BP1 Gene

Regulatory Elements for IGF2BP1 Gene

Enhancers for IGF2BP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H049011 1.5 Ensembl ENCODE dbSUPER 7.8 +17.1 17092 5 FOXA2 ZFP64 SIN3A FEZF1 ZBTB7B ETS1 GLIS2 FOS SP3 SP5 ENSG00000238804 PRAC1 PRAC2 HOXB-AS4 HOXB9 IGF2BP1 ATP5G1 UBE2Z SNF8 ENSG00000255851
GH17H048994 1.6 Ensembl ENCODE dbSUPER 6.9 +2.0 2036 10 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 ENSG00000262837 UBE2Z FAM117A ENSG00000238804 SUMO2P17 KAT7 PRAC1 PRAC2 HOXB13 CALCOCO2
GH17H049035 1.3 Ensembl ENCODE dbSUPER 7.6 +38.6 38597 1 SIX4 CTCF SIN3A RAD21 ZBTB7B CHAMP1 CC2D1A E2F1 POLR2A SMC3 ENSG00000262837 UBE2Z ENSG00000263412 IGF2BP1 GC17P049038 ENSG00000255851
GH17H049020 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.3 +24.6 24583 3 ARID4B ZSCAN9 RFX5 EGR1 SCRT2 RCOR1 ZNF362 HMG20B CEBPB NFYC SNF8 PRAC1 RNU1-42P ENSG00000230532 ENSG00000238804 PRAC2 HOXB-AS4 HOXB9 IGF2BP1 ENSG00000255851
GH17H048970 1.7 FANTOM5 Ensembl ENCODE 1.8 -25.1 -25100 3 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF548 FOS DEK UBE2Z ENSG00000262837 TTLL6 PHOSPHO1 IGF2BP1 SNF8 GIP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGF2BP1 on UCSC Golden Path with GeneCards custom track

Promoters for IGF2BP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095417 1488 4201 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9

Genomic Location for IGF2BP1 Gene

Chromosome:
17
Start:
48,997,412 bp from pter
End:
49,056,145 bp from pter
Size:
58,734 bases
Orientation:
Plus strand

Genomic View for IGF2BP1 Gene

Genes around IGF2BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGF2BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGF2BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2BP1 Gene

Proteins for IGF2BP1 Gene

  • Protein details for IGF2BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZI8-IF2B1_HUMAN
    Recommended name:
    Insulin-like growth factor 2 mRNA-binding protein 1
    Protein Accession:
    Q9NZI8
    Secondary Accessions:
    • C9JT33

    Protein attributes for IGF2BP1 Gene

    Size:
    577 amino acids
    Molecular mass:
    63481 Da
    Quaternary structure:
    • Can form homodimers and heterodimers with IGF2BP1 and IGF2BP3. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. During HCV infection, identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts (via the KH domains) with HIV-1 GAG (via the second zinc finger motif of NC). Associates (via the RRM domains and KH domains) with HIV-1 particles. Identified in a mRNP complex, composed of at least DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with DHX9, ELAVL2, HNRNPA2B1, HNRNPC, HNRNPH1, HNRNPU, IGF2BP2, ILF2, and YBX1. Interacts with FMR1. Component of a multisubunit autoregulatory RNP complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1/UNR. Directly interacts with PABPC1. Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP. Interacts with ELAVL4 in an RNA-dependent manner. Associates with microtubules and polysomes. Interacts with AGO1 and AGO2.

    Three dimensional structures from OCA and Proteopedia for IGF2BP1 Gene

    Alternative splice isoforms for IGF2BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGF2BP1 Gene

Post-translational modifications for IGF2BP1 Gene

  • Phosphorylated. Phosphorylation may impair association with ACTB mRNA and hence abolishes translational repression (By similarity).
  • Ubiquitination at isoforms=23, posLast=2020, isoforms=226, isoforms=138, posLast=213213, isoforms=2440, and isoforms=2475
  • Modification sites at PhosphoSitePlus

Other Protein References for IGF2BP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IGF2BP1 (IGF2BP1)

No data available for DME Specific Peptides for IGF2BP1 Gene

Domains & Families for IGF2BP1 Gene

Gene Families for IGF2BP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for IGF2BP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZI8

UniProtKB/Swiss-Prot:

IF2B1_HUMAN :
  • Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules. KH3 and KH4 mediate association with the cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only KH2 NES is XPO1-dependent. Both NES may be redundant, since individual in vitro mutations do not affect subcellular location of the full length protein. The 4 KH domains are important to suppress HIV-1 infectivity.
  • Belongs to the RRM IMP/VICKZ family.
Domain:
  • Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules. KH3 and KH4 mediate association with the cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only KH2 NES is XPO1-dependent. Both NES may be redundant, since individual in vitro mutations do not affect subcellular location of the full length protein. The 4 KH domains are important to suppress HIV-1 infectivity.
Family:
  • Belongs to the RRM IMP/VICKZ family.
genes like me logo Genes that share domains with IGF2BP1: view

Function for IGF2BP1 Gene

Molecular function for IGF2BP1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3-UTR, known as the zipcode. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5-UTR and 3-UTR and specifically enhances translation at the HCV IRES, but not 5-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.
UniProtKB/Swiss-Prot Induction:
May be up-regulated in response to CTNNB1/beta-catenin activation.

Phenotypes From GWAS Catalog for IGF2BP1 Gene

Gene Ontology (GO) - Molecular Function for IGF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003729 mRNA binding IDA 17101699
GO:0003730 mRNA 3-UTR binding IDA 20080952
GO:0005515 protein binding IPI 17289661
GO:0045182 translation regulator activity IDA 9891060
genes like me logo Genes that share ontologies with IGF2BP1: view
genes like me logo Genes that share phenotypes with IGF2BP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGF2BP1

CRISPR Products

miRNA for IGF2BP1 Gene

miRTarBase miRNAs that target IGF2BP1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IGF2BP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGF2BP1 Gene

Localization for IGF2BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF2BP1 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, dendrite. Cell projection, dendritic spine. Cell projection, growth cone. Cell projection, filopodium. Cell projection, axon. Note=In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription (By similarity). In the cytoplasm, localizes in cytoplasmic mRNP granules. Colocalizes with microtubules in growth cone filopodia and along neurites in neuronal cells (By similarity). Cytoplasmic colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript. In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited (By similarity). In hippocampal neurons, predominantly located within dendrites, particularly at dendritic branching points in young cells, compared to axons (By similarity). In axons, predominantly found in axonal branches and their growth cones (By similarity). In motile cells, such as migrating fibroblasts, localizes to leading edges where it colocalizes with microtubules and microfilaments and to retracting tails (By similarity). Dendritic levels are regulated by neuronal activity and glutaminergic signals: they are increased by KCl-induced depolarization, which induces rapid efflux from the cell body into dendrites, and decreased by the NMDA receptor agonist (By similarity). In motile cells, transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments (By similarity). In response to cellular stress, such as oxidative stress or heat shock, recruited to stress granules, but not to processing bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGF2BP1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
peroxisome 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IGF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 9891060
GO:0005829 cytosol TAS --
GO:0010494 cytoplasmic stress granule IDA 17101699
genes like me logo Genes that share ontologies with IGF2BP1: view

Pathways & Interactions for IGF2BP1 Gene

genes like me logo Genes that share pathways with IGF2BP1: view

Gene Ontology (GO) - Biological Process for IGF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006403 RNA localization IEA --
GO:0006417 regulation of translation IEA --
GO:0006810 transport IEA --
GO:0010610 regulation of mRNA stability involved in response to stress IMP 17101699
GO:0017148 negative regulation of translation IDA 9891060
genes like me logo Genes that share ontologies with IGF2BP1: view

No data available for SIGNOR curated interactions for IGF2BP1 Gene

Drugs & Compounds for IGF2BP1 Gene

No Compound Related Data Available

Transcripts for IGF2BP1 Gene

Unigene Clusters for IGF2BP1 Gene

Insulin-like growth factor 2 mRNA binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IGF2BP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2BP1 Gene

No ASD Table

Relevant External Links for IGF2BP1 Gene

GeneLoc Exon Structure for
IGF2BP1
ECgene alternative splicing isoforms for
IGF2BP1

Expression for IGF2BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGF2BP1 Gene

mRNA differential expression in normal tissues according to GTEx for IGF2BP1 Gene

This gene is overexpressed in Testis (x20.7) and Kidney - Cortex (x6.3).

Protein differential expression in normal tissues from HIPED for IGF2BP1 Gene

This gene is overexpressed in Lung (17.4), Fetal Liver (12.2), Fetal Brain (7.4), Stomach (6.6), and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IGF2BP1 Gene



Protein tissue co-expression partners for IGF2BP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGF2BP1 Gene:

IGF2BP1

SOURCE GeneReport for Unigene cluster for IGF2BP1 Gene:

Hs.144936

mRNA Expression by UniProt/SwissProt for IGF2BP1 Gene:

Q9NZI8-IF2B1_HUMAN
Tissue specificity: Mainly expressed in the embryo, including in fetal liver, fetal lung, fetal kidney, fetal thymus (at protein level). Also expressed follicles of ovary, as well as in gonocytes of testis, spermatogonia, semen, oocytes and placenta (at protein level). Expressed in various cancers, including testis and lung cancers (at protein level), as well as kidney, prostate and trachea cancers.
genes like me logo Genes that share expression patterns with IGF2BP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGF2BP1 Gene

Orthologs for IGF2BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGF2BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGF2BP1 33 34
  • 99.83 (n)
oppossum
(Monodelphis domestica)
Mammalia IGF2BP1 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGF2BP1 33 34
  • 91.05 (n)
dog
(Canis familiaris)
Mammalia IGF2BP1 33 34
  • 90.91 (n)
rat
(Rattus norvegicus)
Mammalia Igf2bp1 33
  • 90.41 (n)
mouse
(Mus musculus)
Mammalia Igf2bp1 33 16 34
  • 89.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IGF2BP1 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGF2BP1 33 34
  • 82.64 (n)
lizard
(Anolis carolinensis)
Reptilia IGF2BP1 34
  • 94 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii igf2bp1 33 34
  • 73.27 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012103 33
  • 55.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta Imp 33 34
  • 53.28 (n)
worm
(Caenorhabditis elegans)
Secernentea zbp-1 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4734 33
Species where no ortholog for IGF2BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IGF2BP1 Gene

ENSEMBL:
Gene Tree for IGF2BP1 (if available)
TreeFam:
Gene Tree for IGF2BP1 (if available)

Paralogs for IGF2BP1 Gene

Paralogs for IGF2BP1 Gene

(3) SIMAP similar genes for IGF2BP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IGF2BP1: view

Variants for IGF2BP1 Gene

Sequence variations from dbSNP and Humsavar for IGF2BP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000008188 -- 49,003,313(+) ATACT(A/G)TACTT intron-variant
rs1000039656 -- 49,044,603(+) TTAGT(G/T)GTCTT intron-variant
rs1000116245 -- 48,996,643(+) GTTCC(A/G/T)CGTGT upstream-variant-2KB
rs1000158135 -- 49,003,300(+) TAAGA(A/G)TGTAT intron-variant
rs1000187886 -- 49,004,361(+) GGAGC(C/T)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGF2BP1 Gene

Variant ID Type Subtype PubMed ID
esv3640732 CNV loss 21293372
nsv1118764 CNV deletion 24896259
nsv474573 CNV novel sequence insertion 20440878
nsv510716 CNV deletion 20534489
nsv833472 CNV gain 17160897
nsv953923 CNV deletion 24416366

Variation tolerance for IGF2BP1 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGF2BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGF2BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGF2BP1 Gene

Disorders for IGF2BP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGF2BP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGF2BP1

Genetic Association Database (GAD)
IGF2BP1
Human Genome Epidemiology (HuGE) Navigator
IGF2BP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGF2BP1
genes like me logo Genes that share disorders with IGF2BP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGF2BP1 Gene

Publications for IGF2BP1 Gene

  1. CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. (PMID: 19647520) Elcheva I … Spiegelman VS (Molecular cell 2009) 3 4 22 60
  2. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PMID: 19029303) Weidensdorfer D … Hüttelmaier S (RNA (New York, N.Y.) 2009) 3 4 22 60
  3. Insulin-like growth factor II mRNA binding protein 1 associates with Gag protein of human immunodeficiency virus type 1, and its overexpression affects virus assembly. (PMID: 18385235) Zhou Y … Liang C (Journal of virology 2008) 3 4 22 60
  4. Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer. (PMID: 17255263) Kato T … Daigo Y (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 4 22 60
  5. CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. (PMID: 16778892) Noubissi FK … Spiegelman VS (Nature 2006) 3 4 22 60

Products for IGF2BP1 Gene

Sources for IGF2BP1 Gene

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