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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGF2BP1 Gene

protein-coding GIFtS: 56
GCID: GC17P047074

insulin-like growth factor 2 mRNA binding protein 1

Explore 23 diseases affiliated with
IGF2BP1 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Insulin-Like Growth Factor 2 MRNA Binding Protein 1¹ ²		ZBP-1² ³
IMP-1¹ ² ³		IGF-II MRNA-Binding Protein 1² ³
CRDBP² ³ ⁵		IGF2 MRNA-Binding Protein 1² ³
ZBP1² ³ ⁵		VICKZ Family Member 1² ³
Coding Region Determinant-Binding Protein² ³		IMP1² ⁵
Zipcode-Binding Protein 1² ³		Insulin-Like Growth Factor 2 MRNA-Binding Protein 1²
CRD-BP² ³		Zip Code-Binding Protein 1³
VICKZ1² ³

External Ids:	HGNC: 28866¹	Entrez Gene: 10642²	Ensembl: ENSG00000159217⁷	OMIM: 608288⁵	UniProtKB: Q9NZI8³

Export aliases for IGF2BP1 gene to outside databases

Previous GC identifers: GC17P044430 GC17P042441

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGF2BP1:

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this

gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain

genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and

regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.

(provided by RefSeq, May 2009)

UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8

Function: RNA-binding factor that affects mRNA nuclear export, localization, stability and translation. Component of

the CRD-mediated complex that promotes MYC mRNA stabilization. Regulates mRNA stability during the integrated cellular

stress response (ISR) in stress granules (SGs). Stabilizes the BTRC/FBW1A mRNA from degradation by disrupting

miRNA-dependent interaction with AGO2. Identified in a HCV IRES-mediated translation complex, that enhances

translation at the Hepatitis C virus (HCV) RNA-replicon via the internal ribosome entry site (IRES), but does not

affect 5'cap-dependent translation. Acts as a HIV-1 retrovirus restriction factor that reduces HIV-1 assembly by

inhibiting viral RNA packaging, assembly and processing of HIV-1 GAG protein on cellular membranes. Binds to mRNAs in

stress granules (SGs). Binds to the stem-loop IV of the 5'-UTR and to the variable region and the poly(U-C) motif of

the 3'-UTR of the HCV RNA-replicon. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulates

its subcellular localization and translation. Binds both to the coding region mRNA stability determinant (CRD) and to

AU-rich sequences in the 3'-UTR of the MYC and CD44 mRNAs and stabilizes these mRNAs. Binds to the fourth and fifth

exons of the oncofetal H19 and neuron-specific TAU mRNAs and regulates their localizations. Binds to the adenine-rich

autoregulatory sequence (ARS) 5'-UTR of the PABPC1 mRNA and is involved in its translational repression. The

RNA-binding activity to ARS is stimulated by PABPC1. Binds to the coding sequence region of BTRC/FBW1A mRNA and

mediates stabilization of BTRC/FBW1A and MYC mRNAs in response to beta-catenin signaling. Binding to RNA employs a

cooperative, sequential mechanism of homo- or heterodimerisation. Also involved in growth or survival of lung-cancer

cells. Protects the MYC and MDR-1 mRNAs from cleavage by a endoribonuclease, thus prolonging their stabilities (By

similarity). Binds to the 3'-UTR axonal localization signal (ALS) of TAU mRNA (By similarity). Binds to a conserved

54-nucleotide element in the 3'-UTR of the beta actin mRNA known as the 'zipcode' (By similarity). Promotes

translocation of the beta-actin mRNA to dendrites (By similarity). May act as a regulator of mRNA transport to

activated synapses in response to synaptic activity (By similarity)

Gene Wiki entry for IGF2BP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGF2BP1 gene promoter:
USF1 MAZR Pax-5 AP-2gamma Zic1 USF-1 AP-2beta Pax-4a AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGF2BP1 promoter sequence

Search SABiosciences Chromatin IP Primers for IGF2BP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGF2BP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32

IGF2BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF2BP1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P047074: view genomic region (about GC identifiers)

Start:	47,074,774 bp from pter	End:	47,133,507 bp from pter
Size:	58,734 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8 (See protein sequence)

Recommended Name: Insulin-like growth factor 2 mRNA-binding protein 1

Size: 577 amino acids; 63481 Da

Subunit: Can form homodimers and heterodimers with IGF2BP1 or IGF2BP3. Component of the coding region determinant

(CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a HCV IRES-mediated

translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts (via the KH domains)

with HIV-1 GAG (via the second zinc finger motif of NC). Associates (via the RRM domains and KH domains) with HIV-1

particles. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1,

PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4,

DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL,

PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts

with DHX9, ELAVL2, HNRNPA2B1, HNRNPC, HNRNPH1, HNRNPU, IGF2BP2, IGF2BP3, ILF2, PABPC1 and YBX1. Found in a RNP granule

complex with FMR1. Interacts with FMR1. Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC),

at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts through the third and fourth KH domains with PABPC1 in a

RNA-independent manner. Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By

similarity). Interacts with ELAVL4 in a RNA-dependent manner (By similarity). Associates with microtubules and

polysomes (By similarity). Interacts with EIF2C1 and EIF2C2

Subcellular location: Nucleus. Cytoplasm. Cell projection, lamellipodium. Cell projection, dendrite (By similarity).

Cell projection, dendritic spine (By similarity). Note=Localized in cytoplasmic mRNP granules containing untranslated

mRNAs. Targeted to stress granules (SGs), but not processing bodies (PBs), during cellular stress. Colocalizes with

G3BP1 and TIAL1 in SGs. Colocalizes with HIV-1 GAG at the cell edges. Found in lamellipodia of the leading edge, in

the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and

regulated by cell contact and growth. Colocalized with H19 RNA at lamellipodia. Colocalized with CD44 mRNA in RNP

granules. Nuclear export is mediated by XPO1/CRM1. In motile cells, is transported towards the leading edge into the

cortical region of the lamellipodia where it is connected to microfilaments (By similarity). Present in the form of

granules and into F-actin-rich protrusion of dendrites, spines and subsynaptic sites (By similarity). Colocalizes with

beta-actin mRNA in dendrites and spines (By similarity). Exhibited rapid, bidirectional movements in dendrites and

spines (By similarity). Neuronal depolarization by KCl induces its rapid efflux from the cell body into dendrites (By

similarity)

1 PDB 3D structure from and Proteopedia for IGF2BP1:

3KRM (3D)

Secondary accessions: C9JT33

Alternative splicing: 2 isoforms: Q9NZI8-1 Q9NZI8-2

Explore the universe of human proteins at neXtProt for IGF2BP1: NX_Q9NZI8

Post-translational modifications:

Phosphorylated. Phosphorylation may influence mRNA translation (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NZI8

IGF2BP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001153895.1 NP_006537.3

ENSEMBL proteins:

ENSP00000290341 ENSP00000389135

Reactome Protein details: Q9NZI8
Human Recombinant Protein Products for IGF2BP1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IGF2BP1 OriGene Protein Over-expression Lysate (see all 2): IGF2BP1 OriGene Custom Protein Services for IGF2BP1
	GenScript Custom Purified and Recombinant Proteins Services for IGF2BP1
	Novus Biologicals IGF2BP1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IGF2BP1

Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IDA	--

IGF2BP1 for ontologies About GeneDecksing

IGF2BP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IGF2BP1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for IGF2BP1 (IMP-1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for IGF2BP1
	GenScript Custom Superior Antibodies Services for IGF2BP1
	Novus Biologicals IGF2BP1 Antibodies
	Abcam antibodies for IGF2BP1
	Uscn Antibodies for IGF2BP1
	ThermoFisher Antibody for IGF2BP1

Assay Products for IGF2BP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IGF2BP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IGF2BP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGF2BP1 for domains About GeneDecksing

4 InterPro domains/families:

IPR004087 KH_dom

IPR012677 Nucleotide-bd_a/b_plait

IPR004088 KH_dom_type_1

IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry Q9NZI8

ProtoNet protein and cluster: Q9NZI8

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB004087 KH domain

UniProtKB/Swiss-Prot: IF2B1_HUMAN, Q9NZI8

Domain: The third and fourth KH domains encompass the protein dimerization motif and are necessary and sufficient for

RNA binding. The four KH domains are important for granule formation and SGs targeting. Contains two nuclear export

signals, situated within the second and fourth KH domains. The four KH domains are important to suppress HIV-1

infectivity

Similarity: Belongs to the RRM IMP/VICKZ family

Similarity: Contains 4 KH domains

Similarity: Contains 2 RRM (RNA recognition motif) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IF2B1_HUMAN, Q9NZI8