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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGF2-AS Gene

RNA gene   GIFtS: 31
GCID: GC11P002167

IGF2 Antisense RNA

(Previous names: insulin-like growth factor 2, antisense, IGF2 antisense...)
(Previous symbol: IGF2AS)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 4

Aliases
IGF2 Antisense RNA1 2     Insulin-Like Growth Factor 2, Antisense1
IGF2AS1 2 3     PEG82
IGF2-AS12 3     IGF2 Antisense Gene Protein 13
IGF2 Antisense RNA (Non-Protein Coding)1     IGF2 Antisense RNA 13
IGF2 Antisense RNA 1 (Non-Protein Coding)1     PEG8/IGF2AS Protein3
Insulin-Like Growth Factor 2 Antisense 1 (Non-Protein Coding)1     Putative Insulin-Like Growth Factor 2 Antisense Gene Protein 13

External Ids:    HGNC: 140621   Entrez Gene: 512142   Ensembl: ENSG000000998697   OMIM: 6101465   UniProtKB: Q6U9493   
ORGUL members:    fRNAdb10:FR142381      
NCBI13:AB030733    
NONCODE14:u36 n37 n408113      

Export aliases for IGF2-AS gene to outside databases

Previous GC identifer: GC11P002163


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGF2-AS Gene:
This gene expresses a paternally imprinted antisense transcript of the insulin-like growth factor 2 gene. The
transcript is overexpressed in Wilms' tumor. This gene is predicted to be non-coding because the predicted
protein is not conserved in any other species and the majority of transcripts would be candidates for non-sense
mediated decay (NMD) if a protein were expressed. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jul 2009)

GeneCards Summary for IGF2-AS Gene: 
IGF2-AS (IGF2 antisense RNA) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with IGF2-AS include wilms tumor, and atherosclerosis.



fRNAdb sequence ontology for IGF2-AS:
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGF2-AS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGF2-AS promoter sequence
   Search SABiosciences Chromatin IP Primers for IGF2-AS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGF2-AS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IGF2-AS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF2-AS gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P002167:  view genomic region     (about GC identifiers)

Start:
2,161,731 bp from pter      End:
2,169,896 bp from pter
Size:
8,166 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for IGF2-AS

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IG2AS_HUMAN, Q6U949 (See protein sequence)
Recommended Name: Putative insulin-like growth factor 2 antisense gene protein  
Size: 168 amino acids; 18035 Da
Developmental stage: Overexpressed in Wilms' tumor samples
Sequence caution: Sequence=BAA90470.1; Type=Frameshift; Positions=162;
Secondary accessions: A5PKV8 A6NNQ2 Q7Z712 Q9P2W0

Explore the universe of human proteins at neXtProt for IGF2-AS: NX_Q6U949

Explore proteomics data for IGF2-AS at MOPED 

IGF2-AS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGF2-AS Protein Expression

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q6U949


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGF2-AS

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for IGF2-AS gene: 
NM_016412.2  

Unigene Cluster for IGF2-AS:

IGF2 antisense RNA
Hs.716962  [show with all ESTs]
Unigene Representative Sequence: NR_028044
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000445504 ENST00000381361(uc001lvk.2 uc010qxi.2 uc001lvl.2)
ENST00000381363
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Additional mRNA sequence: 

AB030733.1 NR_028043.1 NR_028044.1 

3 DOTS entries:

DT.85100504  DT.97788770  DT.100839458 

22 AceView cDNA sequences:

CR595930 CR602283 AY149296 BX369936 AY149295 NM_016412 AB030733 AL521915 
BQ010736 AL530868 BX354029 BX334207 AL530867 BX354028 AL570999 AL545164 
AL529816 AL521914 AL563215 BX397102 AL528643 BX392421 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for IGF2-AS:none

IGF2-AS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGF2-AS Expression
About this image


See IGF2-AS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGF2-AS

SOURCE GeneReport for Unigene cluster: Hs.716962
    SABiosciences Custom PCR Arrays for IGF2-AS
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IGF2-AS gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Igf2as5 insulin-like growth factor 2, antisense   --   7 (87.99 cM) 142659693 


ENSEMBL Gene Tree for IGF2-AS (if available)
TreeFam Gene Tree for IGF2-AS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

4 SNPs in IGF2-AS are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0248474
----see VAR_0248472 T A mis40--------
VAR_0248454
----see VAR_0248452 P T mis40--------
VAR_0248464
----see VAR_0248462 F V mis40--------
VAR_0248444
----see VAR_0248442 S I mis40--------

HapMap Linkage Disequilibrium report for IGF2-AS (2161731 - 2169896 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for IGF2-AS: --
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGF2-AS
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 610146OMIM information: 147470    
6 diseases for IGF2-AS:    About MalaCards
wilms tumor    atherosclerosis    prostate cancer    prostatitis
breast cancer    lung cancer


IGF2-AS for disorders           About GeneDecksing


Export disorders for IGF2-AS gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGF2-AS gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with IGF2-AS)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors. (PubMed id 10731720)1, 2, 3, 9 Okutsu T....Ishino F. (2000)
  2. Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. (PubMed id 12702581)1, 2, 9 Vu T.H.... Hoffman A.R. (2003)
  3. Methylation alterations at imprinted genes detected am ong long-term shiftworkers. (PubMed id 23193016)1 Jacobs D.I....Zhu Y. (2013)
  4. Genome-wide association analysis of autoantibody posit ivity in type 1 diabetes cases. (PubMed id 21829393)1 Plagnol V....Todd J.A. (2011)
  5. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
  6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1 Zhang X....Wu X. (2010)
  7. Prostate cancer risk-associated variants reported fro m genome-wide association studies: meta-analysis and their contribution to gene tic Variation. (PubMed id 20564319)1 Kim S.T....Sun J. (2010)
  8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
  9. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1 McGeachie M....Ramoni M.F. (2009)
  10. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1 Hosgood H.D....Lan Q. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 51214 HGNC: 14062 AceView: IGF2AS Ensembl:ENSG00000099869 euGenes: HUgn51214
ECgene: IGF2-AS H-InvDB: IGF2-AS

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGF2-AS Pharmacogenomics, SNPs, Pathways
SeattleSNPshttp://pga.gs.washington.edu/data/igf2as/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGF2-AS gene:
Search GeneIP for patents involving IGF2-AS

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF2-AS
 inGenious Targeting Laboratory - Custom generated mouse model solutions for IGF2-AS
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGF2-AS
Customized:
 lentivirus for stable overexpression of IGF2-AS
 lentivirus expression plasmids for stable overexpression of IGF2-AS
 adenovirus for overexpression of IGF2-AS
 LSBio Antibodies in human, mouse, rat for IGF2-AS
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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