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Aliases for IGF2-AS Gene

Subcategory (RNA class) for IGF2-AS Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for IGF2-AS Gene

  • IGF2 Antisense RNA 2 3
  • Insulin-Like Growth Factor 2 Antisense 1 (Non-Protein Coding) 2 3
  • IGF2 Antisense RNA 1 (Non-Protein Coding) 2 3
  • IGF2 Antisense RNA (Non-Protein Coding) 2 3
  • IGF2-AS1 3 4
  • IGF2AS 3 4
  • Putative Insulin-Like Growth Factor 2 Antisense Gene Protein 1 4
  • Insulin-Like Growth Factor 2 Antisense (Non-Protein Coding) 3
  • Insulin-Like Growth Factor 2, Antisense 2
  • IGF2 Antisense Gene Protein 1 4
  • PEG8/IGF2AS, Imprinting 3
  • IGF2 Antisense RNA 1 4
  • PEG8/IGF2AS Protein 4
  • PEG8 3

External Ids for IGF2-AS Gene

Previous HGNC Symbols for IGF2-AS Gene

  • IGF2AS

Previous GeneCards Identifiers for IGF2-AS Gene

  • GC11P002163
  • GC11P002167
  • GC11P002171

Summaries for IGF2-AS Gene

Entrez Gene Summary for IGF2-AS Gene

  • This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

GeneCards Summary for IGF2-AS Gene

IGF2-AS (IGF2 Antisense RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Among its related pathways are NF-KappaB Family Pathway and Apoptotic Pathways in Synovial Fibroblasts.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF2-AS Gene

Genomics for IGF2-AS Gene

Genomic Location for IGF2-AS Gene

Chromosome:
11
Start:
2,140,501 bp from pter
End:
2,148,666 bp from pter
Size:
8,166 bases
Orientation:
Plus strand

Genomic View for IGF2-AS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGF2-AS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2-AS Gene

No data available for Regulatory Elements for IGF2-AS Gene

Proteins for IGF2-AS Gene

  • Protein details for IGF2-AS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6U949-IG2AS_HUMAN
    Recommended name:
    Putative insulin-like growth factor 2 antisense gene protein
    Protein Accession:
    Q6U949
    Secondary Accessions:
    • A5PKV8
    • A6NNQ2
    • Q7Z712
    • Q9P2W0

    Protein attributes for IGF2-AS Gene

    Size:
    168 amino acids
    Molecular mass:
    18035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90470.1; Type=Frameshift; Positions=162; Evidence={ECO:0000305};

neXtProt entry for IGF2-AS Gene

Proteomics data for IGF2-AS Gene at MOPED

Post-translational modifications for IGF2-AS Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGF2-AS Gene

Domains & Families for IGF2-AS Gene

Gene Families for IGF2-AS Gene

Protein Domains for IGF2-AS Gene

ProtoNet:

Suggested Antigen Peptide Sequences for IGF2-AS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGF2-AS: view

No data available for UniProtKB/Swiss-Prot for IGF2-AS Gene

Function for IGF2-AS Gene

Phenotypes for IGF2-AS Gene

genes like me logo Genes that share phenotypes with IGF2-AS: view

miRNA for IGF2-AS Gene

miRTarBase miRNAs that target IGF2-AS

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2-AS

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for IGF2-AS Gene

Localization for IGF2-AS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGF2-AS Gene COMPARTMENTS Subcellular localization image for IGF2-AS gene
Compartment Confidence
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IGF2-AS Gene

Pathways & Interactions for IGF2-AS Gene

genes like me logo Genes that share pathways with IGF2-AS: view

Interacting Proteins for IGF2-AS Gene

Gene Ontology (GO) - Biological Process for IGF2-AS Gene

None

No data available for SIGNOR curated interactions for IGF2-AS Gene

Drugs & Compounds for IGF2-AS Gene

No Compound Related Data Available

Transcripts for IGF2-AS Gene

mRNA/cDNA for IGF2-AS Gene

Unigene Clusters for IGF2-AS Gene

IGF2 antisense RNA:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2-AS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2-AS Gene

No ASD Table

Relevant External Links for IGF2-AS Gene

GeneLoc Exon Structure for
IGF2-AS
ECgene alternative splicing isoforms for
IGF2-AS

Expression for IGF2-AS Gene

mRNA expression in normal human tissues for IGF2-AS Gene

mRNA differential expression in normal tissues according to GTEx for IGF2-AS Gene

This gene is overexpressed in Liver (x16.6).

Protein differential expression in normal tissues from HIPED for IGF2-AS Gene

This gene is overexpressed in Plasma (51.5) and Liver, secretome (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGF2-AS Gene



SOURCE GeneReport for Unigene cluster for IGF2-AS Gene Hs.716962

genes like me logo Genes that share expression patterns with IGF2-AS: view

Protein tissue co-expression partners for IGF2-AS Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGF2-AS Gene

Orthologs for IGF2-AS Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IGF2-AS Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Igf2as 16
Species with no ortholog for IGF2-AS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGF2-AS Gene

ENSEMBL:
Gene Tree for IGF2-AS (if available)
TreeFam:
Gene Tree for IGF2-AS (if available)

Paralogs for IGF2-AS Gene

No data available for Paralogs for IGF2-AS Gene

Variants for IGF2-AS Gene

Sequence variations from dbSNP and Humsavar for IGF2-AS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_024844 -
VAR_024845 -
VAR_024846 -
VAR_024847 -

Relevant External Links for IGF2-AS Gene

HapMap Linkage Disequilibrium report
IGF2-AS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGF2-AS Gene

Disorders for IGF2-AS Gene

Relevant External Links for IGF2-AS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGF2-AS
genes like me logo Genes that share disorders with IGF2-AS: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGF2-AS Gene

Publications for IGF2-AS Gene

  1. Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors. (PMID: 10731720) Okutsu T. … Ishino F. (J. Biochem. 2000) 2 23 67
  2. Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer. (PMID: 16624517) Gallagher E. … Mc Cann A. (Genomics 2006) 23 67
  3. Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. (PMID: 12702581) Vu T.H. … Hoffman A.R. (Cancer Res. 2003) 23 67
  4. Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival. (PMID: 24824313) Cao Y. … Ma J. (J. Natl. Cancer Inst. 2014) 67
  5. Methylation alterations at imprinted genes detected among long-term shiftworkers. (PMID: 23193016) Jacobs D.I. … Zhu Y. (Environ. Mol. Mutagen. 2013) 67

Products for IGF2-AS Gene

Sources for IGF2-AS Gene

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