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Aliases for IGF2-AS Gene

Subcategory (RNA class) for IGF2-AS Gene

antisense

Quality Score for this RNA gene is

13

Aliases for IGF2-AS Gene

  • IGF2 Antisense RNA 2 3
  • IGF2AS 3 4 6
  • Insulin-Like Growth Factor 2 Antisense 1 (Non-Protein Coding) 2 3
  • IGF2 Antisense RNA 1 (Non-Protein Coding) 2 3
  • IGF2 Antisense RNA (Non-Protein Coding) 2 3
  • IGF2-AS1 3 4
  • PEG8 3 6
  • Putative Insulin-Like Growth Factor 2 Antisense Gene Protein 1 4
  • Insulin-Like Growth Factor 2 Antisense (Non-Protein Coding) 3
  • Insulin-Like Growth Factor 2, Antisense 2
  • IGF2 Antisense Gene Protein 1 4
  • PEG8/IGF2AS, Imprinting 3
  • IGF2 Antisense RNA 1 4
  • PEG8/IGF2AS Protein 4

External Ids for IGF2-AS Gene

Previous HGNC Symbols for IGF2-AS Gene

  • IGF2AS

Previous GeneCards Identifiers for IGF2-AS Gene

  • GC11P002163
  • GC11P002167
  • GC11P002171

Summaries for IGF2-AS Gene

Entrez Gene Summary for IGF2-AS Gene

  • This gene expresses a paternally imprinted antisense transcript of the insulin-like growth factor 2 gene. The transcript is overexpressed in Wilms' tumor. This gene is predicted to be non-coding because the predicted protein is not conserved in any other species and the majority of transcripts would be candidates for non-sense mediated decay (NMD) if a protein were expressed. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

GeneCards Summary for IGF2-AS Gene

IGF2-AS (IGF2 Antisense RNA) is an RNA Gene, and is affiliated with the antisense RNA class. Diseases associated with IGF2-AS include wilms tumor and lung cancer. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway.

fRNAdb sequence ontologies for IGF2-AS Gene

  • mature_transcript: A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for IGF2-AS Gene

Genomics for IGF2-AS Gene

Genomic Location for IGF2-AS Gene

Start:
2,140,501 bp from pter
End:
2,148,666 bp from pter
Size:
8,166 bases
Orientation:
Plus strand

Genomic View for IGF2-AS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGF2-AS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2-AS Gene

No data available for Regulatory Elements for IGF2-AS Gene

Proteins for IGF2-AS Gene

  • Protein details for IGF2-AS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6U949-IG2AS_HUMAN
    Recommended name:
    Putative insulin-like growth factor 2 antisense gene protein
    Protein Accession:
    Q6U949
    Secondary Accessions:
    • A5PKV8
    • A6NNQ2
    • Q7Z712
    • Q9P2W0

    Protein attributes for IGF2-AS Gene

    Size:
    168 amino acids
    Molecular mass:
    18035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90470.1; Type=Frameshift; Positions=162; Evidence={ECO:0000305};

neXtProt entry for IGF2-AS Gene

Proteomics data for IGF2-AS Gene at MOPED

Post-translational modifications for IGF2-AS Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGF2-AS Gene

Domains for IGF2-AS Gene

Gene Families for IGF2-AS Gene

HGNC:
  • LNCRNA :Long non-coding RNAs

Protein Domains for IGF2-AS Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGF2-AS: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGF2-AS Gene

Function for IGF2-AS Gene

miRNA for IGF2-AS Gene

miRTarBase miRNAs that target IGF2-AS

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2-AS

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGF2-AS Gene

Localization for IGF2-AS Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IGF2-AS Gene

Transcripts for IGF2-AS Gene

mRNA/cDNA for IGF2-AS Gene

Unigene Clusters for IGF2-AS Gene

IGF2 antisense RNA:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2-AS

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IGF2-AS
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2-AS Gene

No ASD Table

Relevant External Links for IGF2-AS Gene

GeneLoc Exon Structure for
IGF2-AS
ECgene alternative splicing isoforms for
IGF2-AS

Expression for IGF2-AS Gene

mRNA expression in normal human tissues for IGF2-AS Gene

mRNA differential expression in normal tissues according to GTEx for IGF2-AS Gene

This gene is overexpressed in Liver (16.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGF2-AS Gene

SOURCE GeneReport for Unigene cluster for IGF2-AS Gene Hs.716962

genes like me logo Genes that share expressions with IGF2-AS: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGF2-AS Gene

Orthologs for IGF2-AS Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IGF2-AS Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Igf2as 16
Species with no ortholog for IGF2-AS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGF2-AS Gene

ENSEMBL:
Gene Tree for IGF2-AS (if available)
TreeFam:
Gene Tree for IGF2-AS (if available)

Paralogs for IGF2-AS Gene

No data available for Paralogs for IGF2-AS Gene

Variants for IGF2-AS Gene

Sequence variations from dbSNP and Humsavar for IGF2-AS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_024844 -
VAR_024845 -
VAR_024846 -
VAR_024847 -

Relevant External Links for IGF2-AS Gene

HapMap Linkage Disequilibrium report
IGF2-AS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGF2-AS Gene

Disorders for IGF2-AS Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for IGF2-AS Gene including...

Search for IGF2-AS Gene in MalaCards »
genes like me logo Genes that share disorders with IGF2-AS: view

No data available for UniProtKB/Swiss-Prot for IGF2-AS Gene

Publications for IGF2-AS Gene

  1. Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors. (PMID: 10731720) Okutsu T. … Ishino F. (J. Biochem. 2000) 2 3 4 23
  2. Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. (PMID: 12702581) Vu T.H. … Hoffman A.R. (Cancer Res. 2003) 3 4 23
  3. Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer. (PMID: 16624517) Gallagher E. … Mc Cann A. (Genomics 2006) 23
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for IGF2-AS Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate IGF2-AS
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2-AS
    • Block miRNA regulation of IGF2-AS using miScript Target Protectors

    Sources for IGF2-AS Gene

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