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IGF2-AS Gene

RNA gene   GIFtS: 27
GCID: GC11P002171

IGF2 Antisense RNA

(Previous names: insulin-like growth factor 2, antisense, IGF2 antisense...)
(Previous symbol: IGF2AS)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): antisense

Quality score for this RNA gene is 4

Aliases
IGF2 Antisense RNA1 2     Insulin-Like Growth Factor 2 Antisense 1 (Non-Protein Coding)1
IGF2AS1 2 3 5     Insulin-Like Growth Factor 2, Antisense1
IGF2-AS12 3     IGF2 Antisense Gene Protein 13
PEG82 5     IGF2 Antisense RNA 13
IGF2 Antisense RNA (Non-Protein Coding)1     PEG8/IGF2AS Protein3
IGF2 Antisense RNA 1 (Non-Protein Coding)1     Putative Insulin-Like Growth Factor 2 Antisense Gene Protein 13

External Ids:    HGNC: 140621   Entrez Gene: 512142   Ensembl: ENSG000000998697   OMIM: 6101465   UniProtKB: Q6U9493   
ORGUL members:    fRNAdb10:FR142381      
NCBI13:AB030733    
NONCODE14:u36 n37 n408113    

Export aliases for IGF2-AS gene to outside databases

Previous GC identifers: GC11P002163 GC11P002167


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGF2-AS Gene:
This gene expresses a paternally imprinted antisense transcript of the insulin-like growth factor 2 gene. The
transcript is overexpressed in Wilms' tumor. This gene is predicted to be non-coding because the predicted
protein is not conserved in any other species and the majority of transcripts would be candidates for non-sense
mediated decay (NMD) if a protein were expressed. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jul 2009)

GeneCards Summary for IGF2-AS Gene:
IGF2-AS (IGF2 antisense RNA) is an RNA gene, and is affiliated with the antisense RNA class. Diseases associated with IGF2-AS include wilms tumor, and lung cancer susceptibility.



fRNAdb sequence ontology for IGF2-AS:
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGF2-AS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGF2-AS promoter sequence
   Search Chromatin IP Primers for IGF2-AS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGF2-AS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IGF2-AS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF2-AS gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P002171:  view genomic region     (about GC identifiers)

Start:
2,161,731 bp from pter      End:
2,169,896 bp from pter
Size:
8,166 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for IGF2-AS

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IG2AS_HUMAN, Q6U949 (See protein sequence)
Recommended Name: Putative insulin-like growth factor 2 antisense gene protein  
Size: 168 amino acids; 18035 Da
Developmental stage: Overexpressed in Wilms' tumor samples
Sequence caution: Sequence=BAA90470.1; Type=Frameshift; Positions=162;
Secondary accessions: A5PKV8 A6NNQ2 Q7Z712 Q9P2W0

Explore the universe of human proteins at neXtProt for IGF2-AS: NX_Q6U949

Explore proteomics data for IGF2-AS at MOPED


See IGF2-AS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q6U949


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IGF2-AS (see all 53)
    Nuclear Receptor Activation by Vitamin-A
Paxillin Interactions
Telomerase Components in Cell Signaling
Mitochondrial Apoptosis
Molecular Mechanisms of Cancer


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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for IGF2-AS (IG2AS)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IGF2-AS gene: 
NM_016412.2  

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000445504(antisense) ENST00000381361(antisense) ENST00000381363(antisense)
miRNA
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  QuantiFast Probe-based Assays in human, mouse, rat IGF2-AS

22 AceView cDNA sequences:

CR602283 CR595930 AB030733 AY149296 AY149295 AL521915 BX369936 NM_016412 
BX354029 BX334207 AL530868 BQ010736 BX354028 AL530867 AL570999 AL545164 
AL529816 AL563215 AL521914 BX397102 AL528643 BX392421 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for IGF2-AS:none

IGF2-AS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGF2-AS Expression
About this image

IGF2-AS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IGF2-AS Protein Expression
    Custom PCR Arrays for IGF2-AS
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF2-AS

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for IGF2-AS gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Igf2as5 insulin-like growth factor 2, antisense   --   7 (87.99 cM) 142659693 


ENSEMBL Gene Tree for IGF2-AS (if available)
TreeFam Gene Tree for IGF2-AS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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4 SNPs for IGF2-AS    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs10034841,2,4
----see VAR_0248472 mis40--------
rs178831421,2,4
----see VAR_0248452 mis40--------
rs10034831,2,4
----see VAR_0248462 mis40--------
rs178834061,2,4
----see VAR_0248442 mis40--------

HapMap Linkage Disequilibrium report for IGF2-AS (2161731 - 2169896 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for IGF2-AS: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGF2-AS
DNA2.0 Custom Variant and Variant Library Synthesis for IGF2-AS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610146OMIM information: 147470    
8 diseases for IGF2-AS:    
About MalaCards
wilms tumor    lung cancer susceptibility    lung cancer    atherosclerosis
type 1 diabetes    prostate cancer    prostatitis    breast cancer


IGF2-AS for disorders           About GeneDecksing


Export disorders for IGF2-AS gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IGF2-AS gene, integrated from 10 sources (see all 24):
(articles sorted by number of sources associating them with IGF2-AS)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors. (PubMed id 10731720)1, 2, 3, 9 Okutsu T....Ishino F. (J. Biochem. 2000)
  2. Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. (PubMed id 12702581)1, 2, 9 Vu T.H.... Hoffman A.R. (Cancer Res. 2003)
  3. Methylation alterations at imprinted genes detected among long-term shiftworkers. (PubMed id 23193016)1 Jacobs D.I....Zhu Y. (Environ. Mol. Mutagen. 2013)
  4. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PubMed id 21829393)1 Plagnol V....Todd J.A. (PLoS Genet. 2011)
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (Eur. Urol. 2010)
  6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1 Zhang X....Wu X. (Carcinogenesis 2010)
  7. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PubMed id 20564319)1 Kim S.T....Sun J. (Prostate 2010)
  8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (Diabetes Care 2010)
  9. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1 McGeachie M....Ramoni M.F. (Circulation 2009)
  10. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1 Hosgood H.D....Lan Q. (Respir Med 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51214 HGNC: 14062 AceView: IGF2AS Ensembl:ENSG00000099869 euGenes: HUgn51214
ECgene: IGF2-AS H-InvDB: IGF2-AS

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IGF2-AS Pharmacogenomics, SNPs, Pathways
SeattleSNPshttp://pga.gs.washington.edu/data/igf2as/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IGF2-AS gene:
Search GeneIP for patents involving IGF2-AS

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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