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Aliases for IGF2 Gene

Aliases for IGF2 Gene

  • Insulin-Like Growth Factor 2 2 3
  • T3M-11-Derived Growth Factor 3 4
  • IGF-II 3 4
  • Insulin-Like Growth Factor 2 (Somatomedin A) 3
  • Chromosome 11 Open Reading Frame 43 2
  • Insulin-Like Growth Factor Type 2 3
  • Insulin-Like Growth Factor II 3
  • Somatomedin A 2
  • Somatomedin-A 4
  • C11orf43 3
  • PP9974 3

External Ids for IGF2 Gene

Previous Symbols for IGF2 Gene

  • C11orf43

Summaries for IGF2 Gene

Entrez Gene Summary for IGF2 Gene

  • This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for IGF2 Gene

IGF2 (Insulin-Like Growth Factor 2) is a Protein Coding gene. Diseases associated with IGF2 include chromosome 11p15.5-related russell-silver syndrome and silver-russell syndrome due to imprinting defect of 11p15. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include growth factor activity and insulin receptor binding. An important paralog of this gene is IGF1.

UniProtKB/Swiss-Prot for IGF2 Gene

  • The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development

  • Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3

Gene Wiki entry for IGF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF2 Gene

Genomics for IGF2 Gene

Genomic Location for IGF2 Gene

Start:
2,129,112 bp from pter
End:
2,149,603 bp from pter
Size:
20,492 bases
Orientation:
Minus strand

Genomic View for IGF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2 Gene

Regulatory Elements for IGF2 Gene

Transcription factor binding sites by QIAGEN in the IGF2 gene promoter:

Proteins for IGF2 Gene

  • Protein details for IGF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01344-IGF2_HUMAN
    Recommended name:
    Insulin-like growth factor II
    Protein Accession:
    P01344
    Secondary Accessions:
    • B3KX48
    • B7WP08
    • C9JAF2
    • E3UN45
    • P78449
    • Q14299
    • Q1WM26
    • Q9UC68
    • Q9UC69

    Protein attributes for IGF2 Gene

    Size:
    180 amino acids
    Molecular mass:
    20140 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGF2 Gene

    Alternative splice isoforms for IGF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGF2 Gene

Proteomics data for IGF2 Gene at MOPED

Post-translational modifications for IGF2 Gene

  • O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr96, Thr99, and Thr163

No data available for DME Specific Peptides for IGF2 Gene

Domains for IGF2 Gene

Graphical View of Domain Structure for InterPro Entry

P01344

UniProtKB/Swiss-Prot:

IGF2_HUMAN
Family:
  • Belongs to the insulin family.:
    • P01344
genes like me logo Genes that share domains with IGF2: view

No data available for Gene Families for IGF2 Gene

Function for IGF2 Gene

Molecular function for IGF2 Gene

GENATLAS Biochemistry: insulin-like growth factor 220kDa,regulator of somatic growth and cellular proliferation,maternally imprinted (telomeric imprinting domain at 11p15,containing ASCL2,H19 and IGF2,silenced and hypermethylated in most Wilms tumor),since the preimplantation 8-cells stage embryos,onwards;biallelic expression and loss of imprinting in fetal brain,in Wilms tumor,Beckwith-Wiedemann syndrome,other tumors and acute myeloid leukemia
UniProtKB/Swiss-Prot Function: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development
UniProtKB/Swiss-Prot Function: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3

LifeMap Function Summary for IGF2 Gene

IGF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005158 insulin receptor binding IPI 12138094
GO:0005159 insulin-like growth factor receptor binding IEA --
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 10611375
GO:0008083 growth factor activity IDA 11500939
genes like me logo Genes that share ontologies with IGF2: view
genes like me logo Genes that share phenotypes with IGF2: view

Animal Models for IGF2 Gene

MGI Knock Outs for IGF2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IGF2 Gene

Localization for IGF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGF2 Gene COMPARTMENTS Subcellular localization image for IGF2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 3
cytosol 3
nucleus 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0031093 platelet alpha granule lumen TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IGF2: view

Pathways for IGF2 Gene

genes like me logo Genes that share pathways with IGF2: view

Gene Ontology (GO) - Biological Process for IGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8298652
GO:0001649 osteoblast differentiation IEA --
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0002576 platelet degranulation TAS --
GO:0006006 glucose metabolic process IEA --
genes like me logo Genes that share ontologies with IGF2: view

Compounds for IGF2 Gene

(134) Novoseek inferred chemical compound relationships for IGF2 Gene

Compound -log(P) Hits PubMed IDs
mannose 6-phosphate 88.6 156
apai 78 44
thymidine 57.4 45
peg-10 56.9 4
ribonucleic acid 55.3 22
genes like me logo Genes that share compounds with IGF2: view

Transcripts for IGF2 Gene

Unigene Clusters for IGF2 Gene

Insulin-like growth factor 2 (somatomedin A):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - -
SP2: -
SP3: -
SP4: - -

Relevant External Links for IGF2 Gene

GeneLoc Exon Structure for
IGF2
ECgene alternative splicing isoforms for
IGF2

Expression for IGF2 Gene

mRNA expression in normal human tissues for IGF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IGF2 Gene

SOURCE GeneReport for Unigene cluster for IGF2 Gene Hs.272259

genes like me logo Genes that share expressions with IGF2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IGF2 Gene

Orthologs for IGF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGF2 35
  • 85.67 (n)
  • 82.98 (a)
IGF2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGF2 35
  • 86.52 (n)
  • 84.83 (a)
IGF2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGF2 35
  • 91.16 (n)
  • 91.71 (a)
IGF2 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igf2 35
  • 86.02 (n)
  • 82.26 (a)
Igf2 16
Igf2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igf2 35
  • 85.84 (n)
  • 83.33 (a)
chicken
(Gallus gallus)
Aves IGF2 35
  • 64.86 (n)
  • 60.84 (a)
IGF2 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGF2 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igf2 35
  • 61.18 (n)
  • 57.93 (a)
Str.10551 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11849 35
zebrafish
(Danio rerio)
Actinopterygii Dr.9288 35
igf2a 36
  • 39 (a)
OneToMany
igf2b 35
  • 59.57 (n)
  • 60 (a)
igf2b 36
  • 45 (a)
OneToMany
Species with no ortholog for IGF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGF2 Gene

ENSEMBL:
Gene Tree for IGF2 (if available)
TreeFam:
Gene Tree for IGF2 (if available)

Paralogs for IGF2 Gene

Paralogs for IGF2 Gene

Selected SIMAP similar genes for IGF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IGF2: view

Variants for IGF2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGF2 Gene

P01344-IGF2_HUMAN
Genetic variations in IGF2 are associated with body mass index (BMI). The BMI is a statistical measurement which compares a persons weight and height

Sequence variations from dbSNP and Humsavar for IGF2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_011959 -
VAR_011960 -
VAR_011961 -

Structural Variations from Database of Genomic Variants (DGV) for IGF2 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV Gain 19166990
dgv992n71 CNV Loss 21882294
dgv993n71 CNV Loss 21882294
nsv896776 CNV Loss 21882294
dgv994n71 CNV Loss 21882294
dgv995n71 CNV Loss 21882294
nsv825707 CNV Gain 20364138
dgv996n71 CNV Loss 21882294
nsv896785 CNV Loss 21882294
esv2673506 CNV Deletion 23128226

Relevant External Links for IGF2 Gene

HapMap Linkage Disequilibrium report
IGF2
Human Gene Mutation Database (HGMD)
IGF2
Locus Specific Mutation Databases (LSDB)
IGF2

Disorders for IGF2 Gene

UniProtKB/Swiss-Prot

IGF2_HUMAN
  • Silver-Russell syndrome (SRS) [MIM:180860]: A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. {ECO:0000269 PubMed:19066168}. Note=The gene represented in this entry is involved in disease pathogenesis. Most of the cases of Silver-Russell syndrome are caused by the epigenetic changes of DNA hypomethylation at the telomeric imprinting control region (ICR1) on chromosome 11p15, involving the H19 and IGF2 genes.

(5) University of Copenhagen DISEASES for IGF2 Gene

(92) Novoseek inferred disease relationships for IGF2 Gene

Disease -log(P) Hits PubMed IDs
beckwith-wiedemann syndrome 88.6 59
wilms tumor 78.1 121
embryonal tumor 72.2 10
hypoglycemia 71.4 175
carcinoma adrenocortical 66.2 35

Genatlas disease for IGF2 Gene

hypoglycemia,tumor induced,putative susceptibility factor for obesity in association with INS in British population

Relevant External Links for IGF2

GeneTests
IGF2
GeneReviews
IGF2
Genetic Association Database (GAD)
IGF2
Human Genome Epidemiology (HuGE) Navigator
IGF2
genes like me logo Genes that share disorders with IGF2: view

Publications for IGF2 Gene

  1. Isolation of a cDNA for a growth factor of vascular endothelial cells from human lung cancer cells: its identity with insulin-like growth factor II. (PMID: 7730145) Hagiwara K. … Okabe T. (Jpn. J. Cancer Res. 1995) 3 4 23
  2. Polymorphism of the IGF2 gene, birth weight and grip strength in adult men. (PMID: 12446294) Sayer A.A. … Cooper C. (Age Ageing 2002) 3 23 48
  3. Detection of bound and free IGF-1 and IGF-2 in human plasma via biomolecular interaction analysis mass spectrometry. (PMID: 12586351) Nedelkov D. … Tubbs K.A. (FEBS Lett. 2003) 3 4 23
  4. Polymorphism of the insulin gene is associated with increased prostate cancer risk. (PMID: 12610512) Ho G.Y. … Chua S.C. (Br. J. Cancer 2003) 3 23 48
  5. An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype. (PMID: 14645199) Murrell A. … Reik W. (Hum. Mol. Genet. 2004) 3 23 48

Products for IGF2 Gene

Sources for IGF2 Gene

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