Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IGF2 Gene

protein-coding   GIFtS: 71
GCID: GC11M002152

Insulin-Like Growth Factor 2 (Somatomedin A)

(Previous name: chromosome 11 open reading frame 43)
(Previous symbol: C11orf43)
  See IGF2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Insulin-Like Growth Factor 2 (Somatomedin A)1 2     Insulin-Like Growth Factor II2
C11orf431 2     Insulin-Like Growth Factor Type 22
IGF-II2 3     somatomedin-A2
Chromosome 11 Open Reading Frame 431     Somatomedin-A3
PP99742     

External Ids:    HGNC: 54661   Entrez Gene: 34812   Ensembl: ENSG000001672447   OMIM: 1474705   UniProtKB: P013443   

Export aliases for IGF2 gene to outside databases

Previous GC identifers: GC11P000574 GC11M002241 GC11M002112 GC11M002118 GC11M002110 GC11M002113 GC11M001942


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IGF2 Gene:
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development
and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this
locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell
syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps
this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Oct 2010)

GeneCards Summary for IGF2 Gene:
IGF2 (insulin-like growth factor 2 (somatomedin A)) is a protein-coding gene. Diseases associated with IGF2 include osteochondrosis, and potter's syndrome. GO annotations related to this gene include growth factor activity and insulin receptor binding. An important paralog of this gene is IGF1.

UniProtKB/Swiss-Prot: IGF2_HUMAN, P01344
Function: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens
for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development
Function: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of
glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity
through phosphoactivation of MAPK1 and MAPK3

Gene Wiki entry for IGF2 (Insulin-like growth factor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGF2 gene promoter:
         AP-1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): IGF2 promoter sequence
   Search Chromatin IP Primers for IGF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IGF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M002152:  view genomic region     (about GC identifiers)

Start:
2,150,342 bp from pter      End:
2,170,833 bp from pter
Size:
20,492 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for IGF2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IGF2_HUMAN, P01344 (See protein sequence)
Recommended Name: Insulin-like growth factor II precursor  
Size: 180 amino acids; 20140 Da
Mass spectrometry: Mass=7469.4; Method=MALDI; Range=25-91; Source=PubMed:12586351, PubMed:15359740;
Mass spectrometry: Mass=7398.3; Method=MALDI; Range=26-91; Source=PubMed:12586351, PubMed:15359740;
6 PDB 3D structures from and Proteopedia for IGF2:
1GF2 (3D)        1IGL (3D)        2L29 (3D)        2V5P (3D)        3E4Z (3D)        3KR3 (3D)    
Secondary accessions: B3KX48 B7WP08 C9JAF2 E3UN45 P78449 Q14299 Q1WM26 Q9UC68 Q9UC69
Alternative splicing: 3 isoforms:  P01344-1   P01344-2   P01344-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for IGF2: NX_P01344

Explore proteomics data for IGF2 at MOPED

Post-translational modifications: 

  • O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-991
  • Glycosylation2 at Thr96, Thr99, Thr163
  • Modification sites at PhosphoSitePlus

  • See IGF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000603.1  NP_001007140.2  NP_001121070.1  

    ENSEMBL proteins: 
     ENSP00000370802   ENSP00000370813   ENSP00000414497   ENSP00000391826   ENSP00000370799  
     ENSP00000370796   ENSP00000402047   ENSP00000300632  
    Reactome Protein details: P01344

    IGF2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IGF2 Protein
    R&D Systems Recombinant & Natural Proteins for IGF2 (IGF-II)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IGF2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IGF2
    GenScript Custom Purified and Recombinant Proteins Services for IGF2
    Novus Biologicals IGF2 Proteins
    Novus Biologicals IGF2 Lysates
    Sino Biological Recombinant Protein for IGF2
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IGF2
    Cloud-Clone Corp. Proteins for IGF2

     
    Search eBioscience for Proteins for IGF2 

    IGF2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IGF2
    R&D Systems Antibodies for IGF2 (IGF-II)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IGF2
    Novus Biologicals IGF2 Antibodies
    Abcam antibodies for IGF2
    Cloud-Clone Corp. Antibodies for IGF2
    ThermoFisher Antibody for IGF2
    LSBio Antibodies in human, mouse, rat for IGF2

    IGF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IGF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IGF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IGF2
    Cloud-Clone Corp. CLIAs for IGF2
    Search eBioscience for ELISAs for IGF2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR016179 Insulin-like
     IPR022350 Insulin-like_growth_factor
     IPR022352 Insulin_family
     IPR022353 Insulin_CS
     IPR022334 IGF2

    Graphical View of Domain Structure for InterPro Entry P01344

    ProtoNet protein and cluster: P01344

    2 Blocks protein domains:
    IPB004825 Insulin/IGF/relaxin
    IPB013576 Insulin-like growth factor II E-peptide


    UniProtKB/Swiss-Prot: IGF2_HUMAN, P01344
    Similarity: Belongs to the insulin family


    Find genes that share domains with IGF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IGF2_HUMAN, P01344
    Function: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens
    for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development
    Function: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of
    glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity
    through phosphoactivation of MAPK1 and MAPK3

         Genatlas biochemistry entry for IGF2:
    insulin-like growth factor 220kDa,regulator of somatic growth and cellular proliferation,maternally imprinted
    (telomeric imprinting domain at 11p15,containing ASCL2,H19 and IGF2,silenced and hypermethylated in most Wilms
    tumor),since the preimplantation 8-cells stage embryos,onwards;biallelic expression and loss of imprinting in
    fetal brain,in Wilms tumor,Beckwith-Wiedemann syndrome,other tumors and acute myeloid leukemia

         Summary: 
    IGF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 4)      
    Adipose: Brown adipocyte-like cells, Spheres       to see all 2 cells
    Brain: Dopaminergic neuron-like cells, Dopaminergic neuron-like cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005158insulin receptor binding IPI12138094
    GO:0005159insulin-like growth factor receptor binding IEA--
    GO:0005179hormone activity IEA--
    GO:0005515protein binding IPI10611375
    GO:0008083growth factor activity IDA11500939
         
    Find genes that share ontologies with IGF2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IGF2:
     Increased cell death in breast 

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Igf2) (see all 23):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with IGF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IGF2: Igf2tm3Wrk Igf2tm1Rob Igf2tm1Wrk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IGF2:
    hsa-mir-877-5p (MIRT037339), hsa-mir-150-5p (MIRT005739), hsa-mir-93-5p (MIRT048842), hsa-mir-615-5p (MIRT007015), hsa-mir-125b-5p (MIRT005738), hsa-let-7a-5p (MIRT004520)

    Block miRNA regulation of human, mouse, rat IGF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGF2 (see all 28):
    hsa-miR-3685 hsa-miR-3194-5p hsa-miR-4286 hsa-miR-125a-3p hsa-miR-522 hsa-miR-200a hsa-miR-548s hsa-miR-141
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IGF2
    Predesigned siRNA for gene silencing in human, mouse, rat IGF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IGF2

    Clone
    Products:
         
    OriGene clones in human, mouse for IGF2 (see all 21)
    OriGene ORF clones in mouse, rat for IGF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IGF2 (NM_001127598)
    Sino Biological Human cDNA Clone for IGF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IGF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for IGF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12450) for IGF2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IGF2_HUMAN, P01344: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytoskeleton3
    cytosol3
    nucleus3
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS--
    GO:0031093platelet alpha granule lumen TAS--

    Find genes that share ontologies with IGF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IGF2 About   (see all 30)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Insulin receptor signalling cascade
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.92
    IGF1R signaling cascade0.92
    SHC-related events triggered by IGF1R0.00


    Find genes that share SuperPaths with IGF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IGF2 (see all 58)
        Nuclear Receptor Activation by Vitamin-A
    RhoA Pathway
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis

    3 GeneGo (Thomson Reuters) Pathways for IGF2
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Cell adhesion ECM remodeling
    Development IGF-1 receptor signaling

    4 BioSystems Pathways for IGF2
        Apoptosis
    Hedgehog Signaling Pathway
    Cardiac Progenitor Differentiation
    Endochondral Ossification


    5 Reactome Pathways for IGF2
        Platelet degranulation
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    IRS-related events triggered by IGF1R
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
    SHC-related events triggered by IGF1R


    1 Kegg Pathway  (Kegg details for IGF2):
        Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGF2 (see all 10): 
              Osteogenesis in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Growth Factors in human mouse rat
              Alzheimer's Disease in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IGF2

    Selected Interacting proteins for IGF2 (P013441, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF2RP117171, 2, 3EBI-7178764,EBI-1048580 MINT-6381282 MINT-6381591 MINT-6381798 MINT-6381176 MINT-6380974 MINT-6381828 MINT-6381259 MINT-6381034 MINT-6381394 MINT-6381465 MINT-6381218 MINT-6381323 MINT-6381777 MINT-6381202 MINT-6381450 MINT-6380995 MINT-6381420 I2D: score=1 
    FAF1Q9UNN52, 3MINT-8258566 I2D: score=2 
    NMRK2Q9NPI52, 3MINT-8258577 I2D: score=2 
    CRELD2Q6UXH12, 3MINT-8258555 I2D: score=1 
    BAG6P463793I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8298652
    GO:0001503ossification ----
    GO:0001649osteoblast differentiation IEA--
    GO:0001934positive regulation of protein phosphorylation ISS--
    GO:0002576platelet degranulation TAS--

    Find genes that share ontologies with IGF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGF2

    Selected Novoseek inferred chemical compound relationships for IGF2 gene (see all 134)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 88.6 306 7814388 (6), 1667383 (5), 1969863 (4), 7588242 (4) (see all 99)
    apai 78 65 15181035 (3), 10738131 (2), 16339295 (2), 9709972 (2) (see all 39)
    thymidine 57.4 53 7512304 (3), 8188767 (2), 2245040 (2), 1407369 (1) (see all 41)
    peg-10 56.9 4 17989250 (1), 15057899 (1), 18805821 (1), 16778176 (1)
    ribonucleic acid 55.3 30 9177379 (2), 11297606 (1), 1656313 (1), 8641194 (1) (see all 21)
    apal 53.7 8 9376897 (3), 8252039 (1), 11855150 (1)
    ag 1024 52.9 5 19764351 (2), 16037379 (1), 14967954 (1)
    c-peptide 50.6 45 11372411 (5), 10400142 (3), 16981978 (2), 8887130 (2) (see all 26)
    nap-2 45.7 2 9268640 (1), 10049585 (1)
    estradiol 42.6 48 8520621 (4), 14967954 (4), 16891052 (3), 8396578 (2) (see all 31)



    Find genes that share compounds with IGF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IGF2 gene (3 alternative transcripts): 
    NM_000612.4  NM_001007139.4  NM_001127598.1  

    Unigene Cluster for IGF2:

    Insulin-like growth factor 2 (somatomedin A)
    Hs.272259  [show with all ESTs]
    Unigene Representative Sequence: NM_000612
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381395(uc009yde.3 uc009ydf.3 uc021qcb.1) ENST00000381406(uc001lvf.3)
    ENST00000416167(uc001lvg.3) ENST00000434045 ENST00000381392(uc001lvj.1)
    ENST00000381389 ENST00000418738 ENST00000300632(uc001lvh.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IGF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGF2 (see all 28):
    hsa-miR-3685 hsa-miR-3194-5p hsa-miR-4286 hsa-miR-125a-3p hsa-miR-522 hsa-miR-200a hsa-miR-548s hsa-miR-141
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IGF2
    Predesigned siRNA for gene silencing in human, mouse, rat IGF2
    Clone
    Products:
         
    OriGene clones in human, mouse for IGF2 (see all 21)
    OriGene ORF clones in mouse, rat for IGF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IGF2 (NM_001127598)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IGF2
    OriGene qSTAR qPCR primer pairs in human, mouse for IGF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IGF2
      QuantiTect SYBR Green Assays in human, mouse, rat IGF2
      QuantiFast Probe-based Assays in human, mouse, rat IGF2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12450) for IGF2 

    Additional mRNA sequence: 

    AF318382.1 AK025719.1 AK126688.1 AK291594.1 AK313938.1 AY899304.1 AY971350.1 BC000531.1 
    BC005255.1 BC011786.2 BC042127.1 BC053318.1 BC073756.1 BC104421.1 BC127839.1 BT006808.1 
    BT007013.1 DQ104203.1 DQ778082.1 HM481219.1 HM481220.1 J03242.1 JF909299.1 JQ951950.1 
    M17426.1 M17863.1 M29645.1 NR_003512.3 S77035.1 X00910.1 X06159.1 X06160.1 
    X06161.1 X06260.1 X70508.1 

    Selected DOTS entries (see all 149):

    DT.99926566  DT.100820923  DT.95278587  DT.97869825  DT.99926560  DT.97863654  DT.91735952  DT.95278349 
    DT.100666628  DT.97850525  DT.420737  DT.99926550  DT.100820911  DT.120755583  DT.97869833  DT.100820920 
    DT.95249342  DT.95278369  DT.120755649  DT.100820919  DT.109985  DT.100820924  DT.100820914  DT.95223278 

    Selected AceView cDNA sequences (see all 48):

    M17426 J03242 BG008906 BQ651107 H57817 BF920316 AW878704 BQ651644 
    AW878689 BF933687 BF933134 BU683154 AA342737 S51971 AA340446 BQ367496 
    BX495883 BG009764 BQ648159 N52638 BC021076 H81229 AW878775 N54394 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IGF2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:        -     -     -           -                           
    SP2:                                -                           
    SP3:                                -                           
    SP4:              -     -                                       


    ECgene alternative splicing isoforms for IGF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IGF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGGGTTTT
    IGF2 Expression
    About this image


    IGF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Medulla Oblongata
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
             mK4
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cardiac Fibroblasts Myocardium
             Atrioventricular Node
             Cardiomyocyte-like progenitor cells
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 4 entries
             Syncytiotrophoblast Multinuclear Cells Chorionic Villus
    IGF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272259
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGF2 (see all 10): 
              Osteogenesis in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Growth Factors in human mouse rat
              Alzheimer's Disease in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IGF2
    OriGene qSTAR qPCR primer pairs in human, mouse for IGF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IGF2
    QuantiTect SYBR Green Assays in human, mouse, rat IGF2
    QuantiFast Probe-based Assays in human, mouse, rat IGF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IGF2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igf21 , 5 insulin-like growth factor 21, 5 86.02(n)1
    82.26(a)1
      7 (87.99 cM)5
    160021  NM_010514.31  NP_034644.21 
     1426507665 
    chicken
    (Gallus gallus)
    Aves IGF21 insulin-like growth factor 2 (somatomedin A) 64.86(n)
    60.84(a)
      395097  NM_001030342.1  NP_001025513.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGF26
    insulin-like growth factor 2 (somatomedin A)
    53(a)
    1 ↔ 1
    1(70065893-70077039)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.105512 Transcribed sequence with weak similarity to protein more 80.31(n)    137713823 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.92882 Danio rerio insulin-like growth factor 2 precursor more 77.35(n)    AF250289.1 


    ENSEMBL Gene Tree for IGF2 (if available)
    TreeFam Gene Tree for IGF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IGF2 gene
    IGF12  
    2 SIMAP similar genes for IGF2 using alignment to 3 protein entries:     IGF2_HUMAN (see all proteins):
    IGF1    IGF-I

    Find genes that share paralogs with IGF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    IGF2_HUMAN, P01344: Genetic variations in IGF2 are associated with body mass index (BMI). The BMI is a statistical
    measurement which compares a person's weight and height


    Selected SNPs for IGF2 (see all 551)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110427511,2
    C,F,H--2083862(-) ATGTCA/GTTAGT 3 -- ds5001 int111Minor allele frequency- G:0.13NA EA CSA 616
    rs767844681,2
    F--2083938(+) CCAGCC/TACAGA 3 -- ds5001 int11Minor allele frequency- T:0.01EA 120
    rs110427531,2
    C,F,A,H--2083993(-) CAACAG/ACCTTA 3 -- ds5001 int113Minor allele frequency- A:0.12NS NA WA 1712
    rs1485760161,2
    --2084059(+) AAAGCC/TCCCCA 3 -- ds5001 int10--------
    rs1920368561,2
    --2084079(+) CCTTCA/GTGGCA 3 -- ds5001 int10--------
    rs1429779491,2
    --2084178(+) GCTCTC/TTCATT 3 -- ds5001 int10--------
    rs801783601,2
    F--2084228(+) CACCCC/TTAAGG 3 -- ds5001 int11Minor allele frequency- T:0.33NA 6
    rs107431341,2
    C,F,H--2084302(+) CCCTCC/TGGCAG 3 -- ds5001 int112Minor allele frequency- T:0.41NA WA CSA EA 376
    rs1465464021,2
    C--2084324(+) AGTCAA/GAGAGT 3 -- ds5001 int10--------
    rs1123724841,2
    C--2084347(+) AGATCT/ATGACT 3 -- ut311Minor allele frequency- A:0.00CSA 1

    HapMap Linkage Disequilibrium report for IGF2 (2150342 - 2170833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for IGF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673506CNV Deletion23128226
    dgv996n71CNV Loss21882294
    dgv994n71CNV Loss21882294
    nsv896776CNV Loss21882294
    dgv995n71CNV Loss21882294
    nsv896785CNV Loss21882294
    dgv992n71CNV Loss21882294
    dgv993n71CNV Loss21882294
    nsv467645CNV Gain19166990
    nsv825707CNV Gain20364138

    Human Gene Mutation Database (HGMD): IGF2
    Locus Specific Mutation Databases (LSDB): IGF2

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGF2
    DNA2.0 Custom Variant and Variant Library Synthesis for IGF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 147470    OMIM disorders: --

    UniProtKB/Swiss-Prot: IGF2_HUMAN, P01344
  • Silver-Russell syndrome (SRS) [MIM:180860]: A clinically heterogeneous condition characterized by severe
    intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face
    and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes
    during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age.
    Note=The gene represented in this entry is involved in disease pathogenesis. Most of the cases of Silver-Russell
    syndrome are caused by the epigenetic changes of DNA hypomethylation at the telomeric imprinting control region
    (ICR1) on chromosome 11p15, involving the H19 and IGF2 genes

  • Selected diseases for IGF2 (see all 35):    
    About MalaCards
    osteochondrosis    potter's syndrome    chromosome 11p15.5-related russell-silver syndrome    hypoglycemic coma
    fetal macrosomia    silver-russell syndrome due to 11p15 microduplication    hemihypertrophy    glycogen storage disease type 1a
    silver-russell syndrome due to imprinting defect of 11p15    hemangiopericytoma    mesoblastic nephroma    acid-labile subunit deficiency
    beckwith-wiedemann syndrome due to imprinting defect of 11p15    focal dermal hypoplasia    silver-russell syndrome    rhabdomyosarcoma
    solitary fibrous tumor    congenital mesoblastic nephroma    multicystic dysplastic kidney    omphalocele

    5 diseases from the University of Copenhagen DISEASES database for IGF2:
    Beckwith-Wiedemann syndrome     Cancer     Silver-Russell syndrome     Hypoglycemia
    Adenoma

    Find genes that share disorders with IGF2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IGF2 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beckwith-wiedemann syndrome 88.6 71 7943172 (4), 9349812 (4), 8320696 (3), 15314640 (2) (see all 46)
    wilms tumor 78.1 166 8825403 (7), 11717330 (6), 9368508 (5), 12702581 (5) (see all 71)
    embryonal tumor 72.2 16 8618347 (1), 11008203 (1), 8298652 (1), 8618920 (1) (see all 10)
    hypoglycemia 71.4 239 1281841 (4), 19259766 (4), 9790231 (4), 2170553 (4) (see all 99)
    carcinoma adrenocortical 66.2 36 18611974 (3), 11889182 (3), 15241731 (3), 8370710 (3) (see all 21)
    tumors 64.9 1113 19383775 (9), 7524924 (6), 9477303 (6), 10682323 (6) (see all 99)
    hepatoblastoma 61.3 37 7543440 (3), 9462704 (3), 11597130 (3), 17072986 (3) (see all 19)
    laron syndrome 59.4 1 7524822 (1)
    cancer embryonal 57.1 1 9484911 (1)
    rhabdomyosarcoma 56.1 67 9771969 (4), 2177632 (4), 7499276 (3), 7686519 (3) (see all 31)

    Genatlas disease: IGF2
    hypoglycemia,tumor induced,putative susceptibility factor for obesity in association with INS in British
    population

    GeneTests: IGF2
    GeneReviews: IGF2
    Genetic Association Database (GAD): IGF2
    Human Genome Epidemiology (HuGE) Navigator: IGF2 (97 documents)

    Export disorders for IGF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IGF2 gene, integrated from 10 sources (see all 2345):
    (articles sorted by number of sources associating them with IGF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. (PubMed id 11448941)1, 2, 4 Gaunt T.R.... O'Dell S.D. (Hum. Mol. Genet. 2001)
    2. Isolation of an insulin-like growth factor II cDNA with a unique 5' untranslated region from human placenta. (PubMed id 2450353)1, 2, 3 Shen S.-J.... Ilan J. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    3. Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein. (PubMed id 3167054)1, 2, 3 de Pagter-Holthuizen P.... Sussenbach J.S. (Biochim. Biophys. Acta 1988)
    4. Genetic predisposition to idiopathic recurrent spontaneous abortion: contribution of genetic variations in IGF-2 and H19 imprinted genes. (PubMed id 18573128)1, 4, 9 OstojiA8 S....Peterlin B. (Am. J. Reprod. Immunol. 2008)
    5. Polymorphism in IGF-2 as a surrogate marker for predisposition towards tobacco chewing-mediated oral cancer. (PubMed id 15970649)1, 4, 9 Kaur R....Das B.R. (Tumour Biol. 2005)
    6. Glutathione S-transferase M1 gene but not insulin-like growth factor-2 gene or epidermal growth factor gene is associated with prostate cancer. (PubMed id 16018936)1, 4, 9 Lai M.T....Chen W.C. (Urol. Oncol. 2005)
    7. Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity. (PubMed id 15181035)1, 4, 9 San MillA!n J.L....Escobar-Morreale H.F. (J. Clin. Endocrinol. Metab. 2004)
    8. IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma. (PubMed id 16750516)1, 4, 9 Kim Y.J....Lee H.S. (Biochem. Biophys. Res. Commun. 2006)
    9. An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype. (PubMed id 14645199)1, 4, 9 Murrell A....Reik W. (Hum. Mol. Genet. 2004)
    10. Polymorphism of the insulin gene is associated with increased prostate cancer risk. (PubMed id 12610512)1, 4, 9 Ho G.Y....Chua S.C. (Br. J. Cancer 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3481 HGNC: 5466 AceView: IGF2 Ensembl:ENSG00000167244 euGenes: HUgn3481
    ECgene: IGF2 Kegg: 3481 H-InvDB: IGF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IGF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGF2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=IGF2[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Insulin-like_growth_factor_2
    SeattleSNPshttp://pga.gs.washington.edu/data/igf2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IGF2 gene:
    Search GeneIP for patents involving IGF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of IGF2
     EMD Millipore Purified and/or Recombinant IGF2 Protein
     
     EMD Millipore genomic analysis products

      
     Antibodies for IGF2 (IGF-II)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for IGF2 (IGF-II)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IGF2  
     OriGene qPCR primer pairs and template standards for IGF2   OriGene Protein Over-expression Lysate for IGF2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for IGF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for IGF2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for IGF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IGF2   OriGene Custom Protein Services for IGF2  

     
     
     Block miRNA regulation of human, mouse, rat IGF2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IGF2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGF2 Predesigned siRNA for gene silencing in human, mouse, rat IGF2
     QuantiFast Probe-based Assays in human, mouse, rat IGF2 QuantiTect SYBR Green Assays in human, mouse, rat IGF2
     PCR Arrays including human, mouse, rat IGF2 Search Chromatin IP Primers for IGF2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IGF2  GeneGlobe Interaction Network for IGF2
     Regulatory tfbs in IGF2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IGF2 GenScript cDNA clones with any tag delivered in your preferred vector for IGF2
     GenScript Custom Assay Services for IGF2 GenScript Custom overexpressing Cell Line Services for IGF2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IGF2
     Proteins for IGF2
     Browse Sino Biological Cell Lysates
     cDNA Clones for IGF2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IGF2 antibodies
     IGF2 proteins
     IGF2 lysates
     Antibodies for IGF2
     See all of Abcam's Antibodies, Kits and Proteins for IGF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for IGF2
     Proteins for IGF2
     Antibodies for IGF2
     ELISAs for IGF2
     CLIAs for IGF2



     Browse ESI BIO Cell Lines and PureStem Progenitors for IGF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IGF2
     SwitchGear Promoter luciferase reporter plasmids for IGF2
     ThermoFisher Antibody for IGF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGF2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGF2
     LSBio Antibodies in human, mouse, rat for IGF2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for IGF2
      Search eBioscience for proteins for IGF2
      Search eBioscience for elisas for IGF2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IGF2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4