Aliases for IGF2 Gene
External Ids for IGF2 Gene
Previous HGNC Symbols for IGF2 Gene
Previous GeneCards Identifiers for IGF2 Gene
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for IGF2 Gene
IGF2 (Insulin Like Growth Factor 2) is a Protein Coding gene. Diseases associated with IGF2 include Growth Restriction, Severe, With Distinctive Facies and Hemihyperplasia, Isolated. Among its related pathways are IL-2 Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include growth factor activity and insulin receptor binding. An important paralog of this gene is IGF1.
UniProtKB/Swiss-Prot for IGF2 Gene
The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.