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IGF2 Gene

protein-coding GIFtS: 72

GC11M002113

insulin-like growth factor 2 (somatomedin A)
(Previous name: chromosome 11 open reading frame 43 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C11orf43)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C11orf43 ^²
FLJ22066 ^²
FLJ44734 ^¹, ²
IGF-II ^³
INSIGF ^²
OTTHUMP00000011012 ^²
OTTHUMP00000011015 ^²
OTTHUMP00000011018 ^²
OTTHUMP00000011157 ^²
Somatomedin-A ^³
pp9974 ^²

Descriptions
chromosome 11 open reading frame 43 ^¹
insulin-like growth factor 2 ^²
insulin-like growth factor 2 (somatomedin A) ^²
insulin-like growth factor II ^²
insulin-like growth factor type 2 ^²
putative insulin-like growth factor II associated protein ^²
somatomedin A ^²

External Ids
HGNC: 5466¹
Entrez Gene: 3481²
UniProtKB: P01344³
Ensembl: ENSG00000167244⁷

Search outside databases for aliases for IGF2 gene

Previous GC identifers: GC11P000574 GC11M002241 GC11M002112 GC11M002118 GC11M002110

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IGF2:

This gene encodes a member of the insulin family of polypeptide growth factors that is involved in

development and growth. It is an imprinted gene and is expressed only from the paternally

inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2,

which aligns to this gene at the 3' region and to the upstream INS gene at the 5'

region. Alternatively spliced transcript variants, encoding either the same or different isoform,

have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: IGF2_HUMAN, P01344

Function: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological

amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing

osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3

Gene Wiki entry for IGF2 (Insulin-like_growth_factor_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IGF2 gene

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

IGF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M002113: (about GC identifiers)

Start:	2,106,918 bp from pter
End:	2,127,409 bp from pter
Size:	20,492 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IGF2_HUMAN, P01344 (See protein sequence)

Recommended Name: Insulin-like growth factor II precursor

Size: 180 amino acids; 20140 Da

Subcellular location: Secreted

Mass spectrometry: Mass=7469.4; Method=MALDI; Range=25-91; Source=PubMed:12586351, PubMed:15359740;

Mass spectrometry: Mass=7398.3; Method=MALDI; Range=26-91; Source=PubMed:12586351, PubMed:15359740;

PDB structures from and Proteopedia :

1GF2 (3D)

1IGL (3D)

2V5P (3D)

Secondary accessions: P78449 Q14299 Q1WM26 Q9UC68 Q9UC69

Alternative splicing: 2 isoforms: P01344-1 P01344-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000603.1 NP_001007140.2 NP_001121070.1

ENSEMBL proteins:

ENSP00000370799 ENSP00000370796 ENSP00000348986 ENSP00000370786 ENSP00000370802 ENSP00000338297

ENSP00000300632 ENSP00000370813

Human Recombinant Proteins

	Invitrogen human recombinant proteins for IGF2
	Millipore Purified and/or Recombinant IGF2 Protein
	Sigma-Aldrich Proteins for IGF2
	R&D Systems Recombinant & Natural Proteins for IGF2 (IGF-II)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IGF2)
	Human Recombinant Proteins from Abnova (IGF2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for IGF2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of IGF2
	Sigma-Aldrich Antibodies for IGF2
	R&D Systems Antibodies for IGF2 (IGF-II)
	Antibodies from Abcam (IGF2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IGF2)
	Novus Biologicals Antibody for IGF2

Assays for IGF2:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of IGF2
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01344

ProtoNet protein and cluster: P01344

2 Blocks protein families:

IPB004825 Insulin/IGF/relaxin

IPB013576 Insulin-like growth factor II E-peptide

UniProtKB/Swiss-Prot: IGF2_HUMAN, P01344

Similarity: Belongs to the insulin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGF2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001007139

Applied Biosystems Silencer® siRNAs for IGF2

Sigma-Aldrich siRNA and siRNA Panels for IGF2

Sigma-Aldrich shRNA for IGF2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IGF2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000612
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000612
untagged cDNA clones in CMV expression vector (see all 4): NM_000612

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001127598

UniProtKB/Swiss-Prot: IGF2_HUMAN, P01344

Function: The insulin-like growth factors possess growth-promoting activity. In vitro, they are

potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role

in fetal development

Function: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological

amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing

osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3

Genatlas biochemistry entry for IGF2:

insulin-like growth factor 220kDa,regulator of somatic growth and cellular proliferation,maternally

imprinted (telomeric imprinting domain at 11p15,containing ASCL2,H19 and IGF2,silenced and

hypermethylated in most Wilms tumor),since the preimplantation 8-cells stage

embryos,onwards;biallelic expression and loss of imprinting in fetal brain,in Wilms

tumor,Beckwith-Wiedemann syndrome,other tumors and acute myeloid leukemia

15/24 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Igf2) (see all 24 ):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005158	insulin receptor binding	IPI	12138094
GO:0005159	insulin-like growth factor receptor binding	TAS	1845984
GO:0005179	hormone activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008083	growth factor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for IGF2 (Your Favorite Gene powered by Ingenuity)

Glioma Signaling
Growth Hormone Signaling

GeneDecks IGF2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for IGF2

1 Interacting protein for IGF2 (P01344²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
IGF2R P11717² MINT-6381282 MINT-6381591 MINT-6381798 MINT-6381176 MINT-6380974 MINT-6381828 MINT-6381259 MINT-6381034 MINT-6381394 MINT-6381465 MINT-6381218 MINT-6381323 MINT-6381777 MINT-6381202 MINT-6381450 MINT-6380995 MINT-6381420
About this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8298652
GO:0006349 genetic imprinting TAS 8968759
GO:0007275 multicellular organismal development TAS 6382022
GO:0008283 cell proliferation IEA --
GO:0008286 insulin receptor signaling pathway TAS 1845984
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for IGF2

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IGF2
10/42 Novoseek chemical compound relationships for IGF2 gene (see all 42 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mannose 6-phosphate	88.54	297	7814388 (6), 1667383 (5), 1969863 (4), 7588242 (4) (see all 99)
apai	77.96	61	15181035 (3), 10738131 (2), 16339295 (2), 9709972 (2) (see all 37)
thymidine	56.73	52	7512304 (3), 8188767 (2), 2245040 (2), 1407369 (1) (see all 40)
ribonucleic acid	56.28	30	9177379 (2), 11297606 (1), 1656313 (1), 8641194 (1) (see all 21)
apal	55.44	8	9376897 (3), 8252039 (1), 11855150 (1)
peg-10	54.84	4	17989250 (1), 15057899 (1), 18805821 (1), 16778176 (1)
c-peptide	50.63	43	11372411 (5), 10400142 (3), 16981978 (2), 19073970 (2) (see all 24)
ag 1024	50.07	3	16037379 (1), 14967954 (1)
estradiol	43.11	45	8520621 (4), 14967954 (4), 16891052 (3), 8396578 (2) (see all 30)
proliferin	42.16	3	1421424 (1), 9202225 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGF2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001007139

Sigma-Aldrich siRNA and siRNA Panels for IGF2

Sigma-Aldrich shRNA for IGF2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000612 NM_001007139 NM_001127598

REFSEQ mRNAs for IGF2 gene (3 alternative transcripts):

NM_000612.4 NM_001007139.4 NM_001127598.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000612 NM_001007139 NM_001127598

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000612
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000612
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_000612

Additional cDNA sequence:

AY971350.1 BC104421.1 BC127839.1 CR620042.1

24/132 DOTS entries (see all 132 ):

DT.99926566 DT.95278587 DT.100820923 DT.97869825 DT.99926560 DT.97863654 DT.95278349 DT.91735952

DT.100666628 DT.97850525 DT.420737 DT.99926550 DT.100820911 DT.120755583 DT.97869833 DT.100820920

DT.95249342 DT.95278369 DT.120755649 DT.100820919 DT.109985 DT.100820924 DT.95223278 DT.100820914

24/48 AceView cDNA sequences (see all 48 ):

T85122 BF933687 BQ651107 BQ367496 N52638 R91389 AA369121 AW878689

BQ651644 S51971 BU683154 AW071552 M17426 BC000531 N72367 H57817

J03242 BQ648159 AW878704 H81229 BG009764 BX495883 BF933134 CR607507

highest scoring ESTs for IGF2:

AW630108 J03242 BC000531 M17426 X06159 AA340446 AA369121 AW411299 AW883539 BF206003

Unigene Clusters for IGF2:

Insulin-like growth factor 2 (somatomedin A)

Hs.272259 [show with all ESTs], Hs.718427 [show with all ESTs]

Unigene Representative Sequences: NM_000612, BQ647339

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for IGF2

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:			-		-		-				-
SP2:											-
SP3:											-
SP4:					-		-

About this scheme

ECgene alternative splicing isoforms for IGF2

8 Ensembl transcripts including schematic representations:

ENST00000381392 ENST00000381389 ENST00000356578 ENST00000381379 ENST00000381395 ENST00000337883

ENST00000300632 ENST00000381406

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IGF2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IGF2

¹ / ² / ³

12 probe-sets matching IGF2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2079_s_at²^{, 3}	U95-A	2	1.00	0.94	0.73	0.91	M13970	0.20	1.00	0.72	1
1591_s_at²^{, 3}	U95-A	2	1.00	0.50	0.59	0.37	J03242	1.00	0.80	0.91	1
36782_s_at²^{, 3}	U95-A	2	1.00	0.50	0.28	0.20	J03242	1.00	0.80	0.91	1
87280_at²^{, 3}	U95-D	1	0.94	1.00	0.53	0.85	AA677597	0.20	0.50	0.38	1
1664_at²^{, 3}	U95-A	1	0.81	1.00	0.88	1.10	HG3543-HT3739	0.20	0.50	0.38	1
55328_r_at²^{, 3}	U95-C	4	0.50	0.41	0.91	1.14	AA595780	0.20	0.06	0.15	1
202409_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X07868	0.20	1.00	0.72	1
210881_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	M17863	0.60	0.83	0.73	1
202410_x_at²^{, 3}	U133-A	2	1.00	0.50	--	--	NM_000612	0.60	1.00	0.82	1
202409_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210881_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
202410_x_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks IGF2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCAGCCCCGT

SOURCE GeneReport for Unigene clusters: Hs.272259 Hs.718427
Expression variation in blood from EXPOLDB for IGF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IGF2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IGF2¹	--	insulin-like growth factor 2 (somatomedin A)	91.3(n) 92.22(a)	483664 XM_858107.1 XP_863200.1
chimpanzee (Pan troglodytes)	IGF2¹	--	insulin-like growth factor 2 (somatomedin A)	83.15(n) 78.89(a)	742381 XM_001153640.1 XP_001153640.1
cow (Bos taurus)	IGF2¹	--	insulin-like growth factor 2 (somatomedin A)	86.52(n) 84.83(a)	281240 NM_174087.2 NP_776512.2
rat (Rattus norvegicus)	Igf2¹	--	insulin-like growth factor 2	86.67(n) 85(a)	24483 NM_031511.1 NP_113699.1
mouse (Mus musculus)	Igf2^{1, 5}	7 (69.09 cM)⁵	insulin-like growth factor 2^{1, 5}	86.85(n)¹ 83.89(a)¹	16002¹ NM_010514.2¹ NP_034644.1¹ AI322387⁵ AI326964⁵ (see all 31)

About this table Species with no ortholog for IGF2

ENSEMBL Gene Tree for IGF2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IGF2 gene

IGF1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/109 NCBI SNPs in IGF2 are shown (see all 109 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 97)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2585^1,2	A,C,F,H,O	2107020(+)	`AGGAGC/TTGAGT`	3	--	ut3¹ ese³		6		MN EU EA WA NA	667
--	rs3168310^1,2	A,C,F	2109117(-)	`GCCCCC/GCTCCT`	3	--	ut3¹ ese³		1		MN	184
	rs3802971^1,2	C,F,H	2108628(-)	`TGATGC/TGGGGA`	3	--	ut3¹ ese³		5		EA EU WA	1722
	rs11042753^1,2	A,C	2106571(-)	`CAACAA/GCCTTA`	2	--	ng5¹		0	--	--	--	--
	rs11042751^1,2	C,F	2106440(-)	`ATGTCA/GTTAGT`	2	--	ng5¹		4		NA EA	362
--	rs680^1,2	C,F	2110210(-)	`GAAGGG/ACCCCA`	3	--	ut3¹ ese³ trp³		3		MN NA	433
	rs12993^1,2	C,H	2110796(-)	`CGGAAG/TTGAGC`	3	K/N	mis¹ ese³		10		MN CSAM EA EU WA	982
	rs7873^1,2	C,F	2107273(-)	`CGACCA/GGCCCC`	3	--	ut3¹ ese³		1		MN	184
	rs14367^1,2	C,H	2110976(-)	`TGGAAG/TCAGTC`	3	K/N	mis¹		10		MN CSAM EA EU WA	992
	rs2230949^1,2	C,F	2110764(-)	`CCCGGC/TGCCAC`	3	--	ut3¹ ese³		8		MN NS CSAM EA	590

About this table

HapMap Linkage Disequilibrium images for IGF2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147470

10/91 Novoseek disease relationships for IGF2 gene (see all 91 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
beckwith-wiedemann syndrome	89.00	71	7943172 (4), 9349812 (4), 8320696 (3), 15314640 (2) (see all 46)
wilms tumor	78.18	163	8825403 (7), 11717330 (6), 9368508 (5), 12702581 (5) (see all 70)
embryonal tumor	73.26	16	8618347 (1), 11008203 (1), 8298652 (1), 8618920 (1) (see all 10)
hypoglycemia	70.97	219	1281841 (4), 9790231 (4), 10586596 (4), 2170553 (4) (see all 97)
carcinoma adrenocortical	65.33	35	18611974 (3), 11889182 (3), 15241731 (3), 8370710 (3) (see all 20)
tumors	64.48	1046	7524924 (6), 9477303 (6), 10682323 (6), 8636375 (6) (see all 99)
hepatoblastoma	60.47	37	7543440 (3), 9462704 (3), 11597130 (3), 17072986 (3) (see all 19)
laron syndrome	60.31	1	7524822 (1)
cancer embryonal	58.06	1	9484911 (1)
rhabdomyosarcoma	56.87	67	9771969 (4), 2177632 (4), 7499276 (3), 7686519 (3) (see all 31)

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2 PharmGKB disease relationships for IGF2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Beckwith-Wiedemann Syndrome	CO GN	15314640
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Genatlas disease: IGF2

hypoglycemia,tumor induced,putative susceptibility factor for obesity in association with INS in

British population

GeneTests: IGF2

Russell-Silver Syndrome

Human Gene Mutation Database: IGF2
Genetic Association Database: IGF2
Human Genome Epidemiology Navigator: IGF2 (53 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Researchers Find Genetic Colon Cancer Change In Healthy Cells

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1949 PubMed articles for IGF2 gene (see all 1949 ):

Isolation of an insulin-like growth factor II cDNA with a unique 5' untranslated region from human placenta. (PubMed id 2450353)^{2, 3, 4} Shen S.-J.... Ilan J. (1988)
Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein. (PubMed id 3167054)^{2, 3, 4} de Pagter-Holthuizen P....Sussenbach J.S. (1988)
Glutathione S-transferase M1 gene but not insulin-like growth factor-2 gene or epidermal growth factor gene is associated with prostate cancer. (PubMed id 16018936)^{1, 3, 6} Lai M.T....Chen W.C. (2005)
Polymorphism in IGF-2 as a surrogate marker for predisposition towards tobacco chewing-mediated oral cancer. (PubMed id 15970649)^{1, 3, 6} Kaur R....Das B.R. (2005)
Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity. (PubMed id 15181035)^{1, 3, 6} San Millan J.L....Escobar-Morreale H.F. (2004)
An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype. (PubMed id 14645199)^{1, 3, 6} Murrell A....Reik W. (2004)
Polymorphism of the insulin gene is associated with increased prostate cancer risk. (PubMed id 12610512)^{1, 3, 6} Ho G.Y....Chua S.C. (2003)
Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes. (PubMed id 16251897)^{1, 3, 6} Rodriguez S....Day I.N. (2006)
Imprinting of IGF2 P0 transcript and novel alternatively spliced INS- IGF2 isoforms show differences between mouse and human. (PubMed id 16531418)^{1, 3, 4} Monk D.... Moore G.E. (2006)
Single-nucleotide polymorphisms and haplotype LD analysis of the 29-kb IGF2 region on chromosome 11p15.5 in the Korean population. (PubMed id 16166779)^{1, 3, 6} Lee H.J....Lee J.Y. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3481	HGNC: 5466	AceView: IGF2	Ensembl:ENSG00000167244	euGenes: HUgn3481
ECgene: IGF2	H-InvDB: IGF2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IGF2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=IGF2
Wikipedia	http://en.wikipedia.org/wiki/Insulin-like_growth_factor_2
SeattleSNPs	http://pga.gs.washington.edu/data/igf2/

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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IGF2 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for IGF2

Summaries
for IGF2

Genomic Location
for IGF2

Proteins
for IGF2

Protein Domains/
Families
for IGF2

Gene Function
for IGF2

Pathways & Interactions
for IGF2

Drugs & Compounds
for IGF2

Transcripts
for IGF2

Expression
for IGF2

Orthologs
for IGF2

Paralogs
for IGF2

SNPs/Variants
for IGF2

Disorders & Mutations
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Medical News
for IGF2

Publications
for IGF2

Search for IGF2

Genome Databases showing IGF2

Other Databases showing IGF2

Specialized Databases showing IGF2

Licensable Technologies
for IGF2

Services
for IGF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IGF2 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor IGF2

Summariesfor IGF2

Genomic Locationfor IGF2

Proteinsfor IGF2

Protein Domains/Familiesfor IGF2

Gene Functionfor IGF2

Pathways & Interactionsfor IGF2

Drugs & Compoundsfor IGF2

Transcriptsfor IGF2

Expression for IGF2

Orthologsfor IGF2

Paralogsfor IGF2

SNPs/Variantsfor IGF2

Disorders & Mutationsfor IGF2

Medical Newsfor IGF2

Publicationsfor IGF2

Search for IGF2

Genome Databases showing IGF2

Other Databases showing IGF2

Specialized Databases showing IGF2

Licensable Technologiesfor IGF2

Servicesfor IGF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IGF2

Summaries
for IGF2

Genomic Location
for IGF2

Proteins
for IGF2

Protein Domains/
Families
for IGF2

Gene Function
for IGF2

Pathways & Interactions
for IGF2

Drugs & Compounds
for IGF2

Transcripts
for IGF2

Expression
for IGF2

Orthologs
for IGF2

Paralogs
for IGF2

SNPs/Variants
for IGF2

Disorders & Mutations
for IGF2

Medical News
for IGF2

Publications
for IGF2

Licensable Technologies
for IGF2

Services
for IGF2