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Aliases for IGF1R Gene

Aliases for IGF1R Gene

  • Insulin-Like Growth Factor 1 Receptor 2 3
  • Insulin-Like Growth Factor I Receptor 3 4
  • IGF-I Receptor 3 4
  • EC 2.7.10.1 4 63
  • Soluble IGF1R Variant 1 3
  • Soluble IGF1R Variant 2 3
  • CD221 Antigen 4
  • EC 2.7.10 63
  • CD221 3
  • IGFIR 3
  • JTK13 3
  • IGFR 3

External Ids for IGF1R Gene

Previous GeneCards Identifiers for IGF1R Gene

  • GC15P095878
  • GC15P093033
  • GC15P096785
  • GC15P096928
  • GC15P097010
  • GC15P099192
  • GC15P075320

Summaries for IGF1R Gene

Entrez Gene Summary for IGF1R Gene

  • This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for IGF1R Gene

IGF1R (Insulin-Like Growth Factor 1 Receptor) is a Protein Coding gene. Diseases associated with IGF1R include insulin-like growth factor i and insulin-like growth factor 1 resistance to. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include identical protein binding and insulin receptor binding. An important paralog of this gene is ALK.

UniProtKB/Swiss-Prot for IGF1R Gene

  • Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R

  • When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin

Tocris Summary for IGF1R Gene

  • Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IR homodimers are activated by insulin and in adults, mediate an increase in glucose uptake through upregulation of Glut4 expression. Two isoforms of the IR exist; fetal IR-A and adult IR-B. IGF1R homodimers are activated by IGF-I and IGF-II and mediate pre- and postnatal growth. IGF2R sequesters IGF-II and acts to regulate its levels. IR-IGF1R heterodimers exist and, like IGF1R homodimers, are activated by IGF-I and IGF-II. IRs and IGFRs mediate their intracellular actions through the PI 3-K and RAS/RAF/MAPK signaling pathways and downstream effectors include mTOR, p70 S6 kinase, ERK and JNK. Many tumors have altered expression of IGF1R and its ligands and this constitutes an early, possible initiating, event in tumorigenesis. Decreases in IR signaling causing insulin resistance is a major component in the development of type 2 diabetes and congenital mutations in the IR can cause the fatal Donohue syndrome.

Gene Wiki entry for IGF1R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF1R Gene

Genomics for IGF1R Gene

Regulatory Elements for IGF1R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IGF1R Gene

Start:
98,648,971 bp from pter
End:
98,964,530 bp from pter
Size:
315,560 bases
Orientation:
Plus strand

Genomic View for IGF1R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGF1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF1R Gene

Proteins for IGF1R Gene

  • Protein details for IGF1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08069-IGF1R_HUMAN
    Recommended name:
    Insulin-like growth factor 1 receptor
    Protein Accession:
    P08069
    Secondary Accessions:
    • B1B5Y2
    • Q14CV2
    • Q9UCC0

    Protein attributes for IGF1R Gene

    Size:
    1367 amino acids
    Molecular mass:
    154793 Da
    Quaternary structure:
    • Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1. Interacts with SOCS1, SOCS2 and SOCS3. Interacts with 14-3-3 proteins. Interacts with NMD2. Interacts with MAP3K5. Interacts with STAT3.
    SequenceCaution:
    • Sequence=BAG11657.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGF1R Gene

neXtProt entry for IGF1R Gene

Proteomics data for IGF1R Gene at MOPED

Post-translational modifications for IGF1R Gene

  • Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a sequential manner; Tyr-1165 is predominantly phosphorylated first, followed by phosphorylation of Tyr-1161 and Tyr-1166. While every single phosphorylation increases kinase activity, all three tyrosine residues in the kinase activation loop (Tyr-1165, Tyr-1161 and Tyr-1166) have to be phosphorylated for optimal activity. Can be autophosphorylated at additional tyrosine residues (in vitro). Autophosphorylated is followed by phosphorylation of juxtamembrane tyrosines and C-terminal serines. Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding. Phosphorylation of Ser-1278 by GSK-3beta restrains kinase activity and promotes cell surface expression, it requires a priming phosphorylation at Ser-1282. Dephosphorylated by PTPN1 (By similarity).
  • Controlled by regulated intramembrane proteolysis (RIP). Undergoes metalloprotease-dependent constitutive ectodomain shedding to produce a membrane-anchored 52 kDa C-Terminal fragment which is further processed by presenilin gamma-secretase to yield an intracellular 50 kDa fragment.
  • Polyubiquitinated at Lys-1168 and Lys-1171 through both Lys-48 and Lys-29 linkages, promoting receptor endocytosis and subsequent degradation by the proteasome. Ubiquitination is facilitated by pre-existing phosphorylation.
  • Sumoylated with SUMO1.
  • Ubiquitination at Lys1033, Lys1168, and Lys1171
  • Glycosylation at Asn51, Asn102, Asn135, Asn244, Asn314, Asn417, Asn438, Asn534, Asn607, Asn622, Asn640, Asn747, Asn756, Asn764, Asn900, and Asn913
  • Modification sites at PhosphoSitePlus

Other Protein References for IGF1R Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IGF1R (IGF1R)

Protein Products

Domains for IGF1R Gene

Gene Families for IGF1R Gene

HGNC:
  • CD :CD molecules
  • FN3 :Fibronectin type III domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for IGF1R Gene

Graphical View of Domain Structure for InterPro Entry

P08069

UniProtKB/Swiss-Prot:

IGF1R_HUMAN :
  • P08069
Domain:
  • Contains 4 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with IGF1R: view

Function for IGF1R Gene

Molecular function for IGF1R Gene

GENATLAS Biochemistry: insulin-like growth factor 1,receptor
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by autophosphorylation at Tyr-1165, Tyr-1161 and Tyr-1166 on the kinase activation loop; phosphorylation at all three tyrosine residues is required for optimal kinase activity. Inhibited by MSC1609119A-1, BMS-754807, PQIP, benzimidazole pyridinone, isoquinolinedione, bis-azaindole, 3-cyanoquinoline, 2,4-bis-arylamino-1,3-pyrimidine, pyrrolopyrimidine, pyrrole-5-carboxaldehyde, picropodophyllin (PPP), tyrphostin derivatives. While most inhibitors bind to the ATP binding pocket, MSC1609119A-1 functions as allosteric inhibitor and binds close to the DFG motif and the activation loop.
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R
UniProtKB/Swiss-Prot Function: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin

Enzyme Numbers (IUBMB) for IGF1R Gene

Gene Ontology (GO) - Molecular Function for IGF1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004714 transmembrane receptor protein tyrosine kinase activity --
GO:0005010 insulin-like growth factor-activated receptor activity IDA 7679099
genes like me logo Genes that share ontologies with IGF1R: view
genes like me logo Genes that share phenotypes with IGF1R: view

Animal Models for IGF1R Gene

MGI Knock Outs for IGF1R:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF1R

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for IGF1R Gene

Localization for IGF1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF1R Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGF1R Gene COMPARTMENTS Subcellular localization image for IGF1R gene
Compartment Confidence
plasma membrane 4
extracellular 3
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IGF1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 7679099
GO:0005901 caveola IEA --
GO:0016020 membrane IDA 8452530
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with IGF1R: view

Pathways for IGF1R Gene

genes like me logo Genes that share pathways with IGF1R: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IGF1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0006955 immune response IMP 16886151
GO:0007165 signal transduction TAS 3003744
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway --
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with IGF1R: view

Compounds for IGF1R Gene

Compound Products

(5) Tocris Compounds for IGF1R Gene

Compound Action Cas Number
BMS 536924 Dual IR/IGF1R inhibitor [468740-43-4]
Demethylasterriquinone B1 Selective insulin RTK activator [78860-34-1]
Insulin (human) recombinant Endogenous peptide agonist [11061-68-0]
NVP ADW 742 ATP-competitive inhibitor of IGF1R [475488-23-4]
Picropodophyllotoxin Selective IGF1R inhibitor [477-47-4]

(8) ApexBio Compounds for IGF1R Gene

Compound Action Cas Number
AG-1024 selectively IGF-1R inhibitor [65678-07-1]
AXL1717 orally active IGF-1R inhibitor [477-47-4]
BMS-536924 Dual inhibitor of the IR and IGF1R [468740-43-4]
BMS-754807 Orally bioavailable antagonist of IGF-1R [1001350-96-4]
GSK1904529A Selective IGF1R inhibitor [1089283-49-7]
Linsitinib Dual inhibitor of IGF1R and IR [867160-71-2]
NVP-AEW541 dual inhibitor of IGF-IR and InsR [475489-16-8]
PQ 401 IGF1R inhibitor. [196868-63-0]

(2) HMDB Compounds for IGF1R Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) IUPHAR Ligand for IGF1R Gene

Ligand Type Action Affinity Pubmed IDs
IGF1 None None
IGF2 None None

(129) Novoseek inferred chemical compound relationships for IGF1R Gene

Compound -log(P) Hits PubMed IDs
ag 1024 89.1 23
tyrosine 79.5 137
mannose 6-phosphate 72.3 27
phosphatidylinositol 71.4 43
podophyllotoxin 62.5 16
genes like me logo Genes that share compounds with IGF1R: view

Transcripts for IGF1R Gene

Unigene Clusters for IGF1R Gene

Insulin-like growth factor 1 receptor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF1R

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IGF1R

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGF1R Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - - - - -
SP2:
SP3: - - -
SP4: - - - -
SP5:
SP6: - - - - -
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for IGF1R Gene

GeneLoc Exon Structure for
IGF1R
ECgene alternative splicing isoforms for
IGF1R

Expression for IGF1R Gene

mRNA expression in normal human tissues for IGF1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGF1R Gene

SOURCE GeneReport for Unigene cluster for IGF1R Gene Hs.643120

mRNA Expression by UniProt/SwissProt for IGF1R Gene

P08069-IGF1R_HUMAN
Tissue specificity: Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney.
genes like me logo Genes that share expressions with IGF1R: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for IGF1R Gene

Orthologs for IGF1R Gene

This gene was present in the common ancestor of animals.

Orthologs for IGF1R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGF1R 35
  • 99.49 (n)
  • 99.71 (a)
IGF1R 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGF1R 35
  • 91.44 (n)
  • 97.73 (a)
IGFR1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGF1R 35
  • 91.68 (n)
  • 98.24 (a)
IGF1R 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igf1r 35
  • 89.56 (n)
  • 96.12 (a)
Igf1r 16
Igf1r 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGF1R 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGF1R 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igf1r 35
  • 89.35 (n)
  • 95.82 (a)
chicken
(Gallus gallus)
Aves IGF1R 35
  • 79.45 (n)
  • 85.37 (a)
IGF1R 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGF1R 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398022 35
tropical clawed frog
(Silurana tropicalis)
Amphibia igf1r 35
  • 72.12 (n)
  • 77.42 (a)
Str.14302 35
zebrafish
(Danio rerio)
Actinopterygii igf1ra 35
  • 68.51 (n)
  • 69.08 (a)
igf1ra 36
  • 66 (a)
OneToMany
igf1rb 36
  • 64 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta INR 35
  • 50.28 (n)
  • 46.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3837 36
  • 28 (a)
OneToMany
InR 35
  • 50.34 (n)
  • 41.89 (a)
CG10702 37
  • 26 (a)
hop 37
  • 34 (a)
sev 37
  • 49 (a)
InR 37
  • 37 (a)
CG3837 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea daf-2 35
  • 45.03 (n)
  • 35.98 (a)
daf-2 36
  • 23 (a)
OneToMany
T25B9.5 37
  • 32 (a)
W02A2.4 37
  • 34 (a)
R151.4 37
  • 38 (a)
K09B11.5 37
  • 35 (a)
C24G6.2a 37
  • 34 (a)
Y69E1A.3 37
  • 32 (a)
C24G6.2b 37
  • 34 (a)
daf-2 37
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.344 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for IGF1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IGF1R Gene

ENSEMBL:
Gene Tree for IGF1R (if available)
TreeFam:
Gene Tree for IGF1R (if available)

Paralogs for IGF1R Gene

Paralogs for IGF1R Gene

genes like me logo Genes that share paralogs with IGF1R: view

Variants for IGF1R Gene

Sequence variations from dbSNP and Humsavar for IGF1R Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs702497 -- 98,958,352(+) AGCAG(C/T)CTGGC utr-variant-3-prime
rs867431 -- 98,906,454(-) CTCAT(A/G)GGTTT intron-variant
rs870306 -- 98,776,578(-) AGGGA(A/C)GAGGC intron-variant
rs871334 -- 98,936,520(+) TACTG(A/G)GTAAG intron-variant
rs871335 -- 98,936,717(+) TTCAT(A/G/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGF1R Gene

Variant ID Type Subtype PubMed ID
nsv827457 CNV Gain 20364138
esv27037 CNV Loss 19812545
esv2750108 CNV Deletion 23290073
esv2750109 CNV Deletion 23290073
esv32729 CNV Gain 17666407
esv33604 CNV Gain 17666407
nsv526399 CNV Loss 19592680
nsv904540 CNV Loss 21882294
nsv904541 CNV Loss 21882294

Relevant External Links for IGF1R Gene

HapMap Linkage Disequilibrium report
IGF1R
Human Gene Mutation Database (HGMD)
IGF1R
Locus Specific Mutation Databases (LSDB)
IGF1R

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGF1R Gene

Disorders for IGF1R Gene

(1) OMIM Diseases for IGF1R Gene (147370)

UniProtKB/Swiss-Prot

IGF1R_HUMAN
  • Insulin-like growth factor 1 resistance (IGF1RES) [MIM:270450]: A disorder characterized by intrauterine growth retardation, poor postnatal growth and increased plasma IGF1 levels. {ECO:0000269 PubMed:14657428, ECO:0000269 PubMed:15928254}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(93) Novoseek inferred disease relationships for IGF1R Gene

Disease -log(P) Hits PubMed IDs
igf-i resistance 82.9 7
breast cancer 66.9 156
tumors 65.7 162
leprechaunism 63.8 1
cancer 60.2 136

Relevant External Links for IGF1R

Genetic Association Database (GAD)
IGF1R
Human Genome Epidemiology (HuGE) Navigator
IGF1R
Tumor Gene Database (TGDB):
IGF1R
genes like me logo Genes that share disorders with IGF1R: view

Publications for IGF1R Gene

  1. IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. (PMID: 14657428) Abuzzahab M.J. … Chernausek S.D. (N. Engl. J. Med. 2003) 3 4 23 48
  2. Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. (PMID: 12821780) Girnita L. … Larsson O. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  3. Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). (PMID: 7679099) Kato H. … LeRoith D. (J. Biol. Chem. 1993) 3 4 23
  4. Expression of the type 1 insulin-like growth factor receptor is up- regulated in primary prostate cancer and commonly persists in metastatic disease. (PMID: 12019176) Hellawell G.O. … Macaulay V.M. (Cancer Res. 2002) 3 4 23
  5. Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study. (PMID: 15127203) Laukkanen O. … Laakso M. (Diabetologia 2004) 3 23 48

Products for IGF1R Gene

  • Addgene plasmids for IGF1R

Sources for IGF1R Gene

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