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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGF1R Gene

protein-coding   GIFtS: 80
GCID: GC15P099192

insulin-like growth factor 1 receptor
 Explore 180 diseases affiliated with
IGF1R via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGF1R    

Aliases
for IGF1R gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Insulin-Like Growth Factor 1 Receptor1 2     EC 2.7.10.13 8
CD2211 2     MGC182161
IGFIR1 2     Soluble IGF1R Variant 12
IGFR1 2     Soluble IGF1R Variant 22
JTK131 2     CD221 Antigen3
Insulin-Like Growth Factor I Receptor2 3     EC 2.7.108
IGF-I Receptor2 3     

External Ids:    HGNC: 54651   Entrez Gene: 34802   Ensembl: ENSG000001404437   OMIM: 1473705   UniProtKB: P080693   

Export aliases for IGF1R gene to outside databases

Previous GC identifers: GC15P095878 GC15P093033 GC15P096785 GC15P096928 GC15P097010 GC15P075320


Summaries
for IGF1R gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IGF1R:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like
growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and
beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by
enhancing cell survival. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
Function: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high
affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival
control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the
receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that
function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins.
Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and
the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas
activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the
85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein
AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the
antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling,
recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK
pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal
transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to
phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular
activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene
transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able
to directly associate with the IGF1R
Function: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed
of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not
significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated
by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform
Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind
IGF1 and have a low affinity for insulin

summary for IGF1R:
Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each
of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular
tyrosine kinase activity. IR homodimers are activated by insulin and in adults, mediate an increase in
glucose uptake through upregulation of Glut4 expression. Two isoforms of the IR exist; fetal IR-A and adult
IR-B. IGF1R homodimers are activated by IGF-I and IGF-II and mediate pre- and postnatal growth. IGF2R
sequesters IGF-II and acts to regulate its levels. IR-IGF1R heterodimers exist and, like IGF1R homodimers,
are activated by IGF-I and IGF-II. IRs and IGFRs mediate their intracellular actions through the PI 3-K and
RAS/RAF/MAPK signaling pathways and downstream effectors include mTOR, p70 S6 kinase, ERK and JNK. Many
tumors have altered expression of IGF1R and its ligands and this constitutes an early, possible initiating,
event in tumorigenesis. Decreases in IR signaling causing insulin resistance is a major component in the
development of type 2 diabetes and congenital mutations in the IR can cause the fatal Donohue syndrome.

Gene Wiki entry for IGF1R (Insulin-like growth factor 1 receptor)


Genomic Views
for IGF1R gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010274.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGF1R gene promoter:
         MEF-2A   TBP   STAT1   AP-1   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): IGF1R promoter sequence
   Search SABiosciences Chromatin IP Primers for IGF1R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGF1R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

IGF1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF1R gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P099192:  view genomic region     (about GC identifiers)

Start:
 99,192,200 bp from pter      End:
 99,507,759 bp from pter
Size:
 315,560 bases      Orientation:
 plus strand

Proteins
for IGF1R gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069 (See protein sequence)
Recommended Name: Insulin-like growth factor 1 receptor precursor  
Size: 1367 amino acids; 154793 Da
Subunit: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation
of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the
PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with
INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain
of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1. Interacts with SOCS1,
SOCS2 and SOCS3. Interacts with 14-3-3 proteins. Interacts with NMD2. Interacts with MAP3K5. Interacts with STAT3
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=BAG11657.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/17 PDB 3D structures from and Proteopedia for IGF1R (see all 17):
1IGR (3D)        1JQH (3D)        1K3A (3D)        1M7N (3D)        1P4O (3D)        2OJ9 (3D)    
Secondary accessions: B1B5Y2 Q14CV2 Q9UCC0

Explore the universe of human proteins at neXtProt for IGF1R: NX_P08069

Post-translational modifications:

  • Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one
    • subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a
    sequential manner; Tyr-1165 is predominantly phosphorylated first, followed by phosphorylation of Tyr-1161 and
    Tyr-1166. While every single phosphorylation increases kinase activity, all three tyrosine residues in the kinase
    activation loop (Tyr-1165, Tyr-1161 and Tyr-1166) have to be phosphorylated for optimal activity. Can be
    autophosphorylated at additional tyrosine residues (in vitro). Autophosphorylated is followed by phosphorylation of
    juxtamembrane tyrosines and C-terminal serines. Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding.
    Dephosphorylated by PTPN1 (By similarity)1
  • Polyubiquitinated at Lys-1168 and Lys-1171 through both 'Lys-48' and 'Lys-29' linkages, promoting receptor endocytosis
    • and subsequent degradation by the proteasome. Ubiquitination is facilitated by pre-existing phosphorylation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08069

    • 4/43 DME Specific Peptides for IGF1R (P08069) (see all 43)
     LMRMCWQ  DGQDACG  PESLKDG  RDLAARN 

    IGF1R Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000866.1  
    ENSEMBL proteins: 
     ENSP00000268035   ENSP00000453007   ENSP00000453630   ENSP00000454115   ENSP00000456950  
     ENSP00000453180  
    Reactome Protein details: P08069
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant IGF1R Protein
    R&D Systems Recombinant & Natural Proteins for IGF1R (IGF-I R)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IGF1R
    OriGene Protein Over-expression Lysate: IGF1R
    OriGene Custom Protein Services for IGF1R 
    GenScript Custom Purified and Recombinant Proteins Services for IGF1R
    Novus Biologicals IGF1R Proteins
    Novus Biologicals IGF1R Lysates
    Sino Biological Recombinant Protein for IGF1R
    ProSpec Recombinant Protein for IGF1R
    Uscn Proteins for IGF1R

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005792microsome ----
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane IC7679099
    GO:0005901caveola IEA--
    GO:0016020membrane IDA8452530


    IGF1R for ontologies           About GeneDecksing



    IGF1R Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IGF1R
    R&D Systems Antibodies for IGF1R (IGF-I R)
    Cell Signaling Technology (CST) Antibodies for IGF1R 
    OriGene Antibodies (see all 3): IGF1R
    OriGene Custom Antibody Services for IGF1R 
    GenScript Superior Antibodies for IGF1R
    Novus Biologicals IGF1R Antibodies
    Abcam antibodies for IGF1R 
    Uscn Antibodies for IGF1R
    ThermoFisher Antibody for IGF1R

    Assay Products for IGF1R: 
    EMD Millipore Kits and Assays for the Analysis of IGF1R
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for IGF1R (IGF-I R)         (see all)
    GenScript IGF1R-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for IGF1R
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IGF1R

    Protein Domains /
    Families
    for IGF1R gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGF1R for domains           About GeneDecksing

    5/14 InterPro domains/families (see all 14):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR003961 Fibronectin_type3
     IPR011009 Kinase-like_dom
     IPR002011 Tyr_kinase_rcpt_2_CS

    Graphical View of Domain Structure for InterPro Entry P08069

    ProtoNet protein and cluster: P08069

    5/6 Blocks protein families (see all 6):
    IPB000463 Cytosolic fatty-acid binding protein
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB002011 Receptor tyrosine kinase
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain


    Function
    for IGF1R gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
    Function: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high
    affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival
    control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the
    receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that
    function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins.
    Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and
    the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas
    activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the
    85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein
    AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the
    antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling,
    recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK
    pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal
    transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to
    phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular
    activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene
    transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
    IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able
    to directly associate with the IGF1R
    Function: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed
    of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not
    significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated
    by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform
    Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind
    IGF1 and have a low affinity for insulin
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by autophosphorylation at Tyr-1165, Tyr-1161 and Tyr-1166 on the kinase activation loop;
    phosphorylation at all three tyrosine residues is required for optimal kinase activity. Inhibited by MSC1609119A-1,
    BMS-754807, PQIP, benzimidazole pyridinone, isoquinolinedione, bis-azaindole, 3-cyanoquinoline,
    2,4-bis-arylamino-1,3-pyrimidine, pyrrolopyrimidine, pyrrole-5-carboxaldehyde, picropodophyllin (PPP), tyrphostin
    derivatives. While most inhibitors bind to the ATP binding pocket, MSC1609119A-1 functions as allosteric inhibitor and
    binds close to the DFG motif and the activation loop

         Genatlas biochemistry entry for IGF1R:
    insulin-like growth factor 1,receptor

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		miRTarBase miRNAs that target IGF1R:
    hsa-mir-194 (MIRT005892), hsa-mir-7 (MIRT005364), hsa-mir-145 (MIRT004931), hsa-mir-133b (MIRT004460), hsa-mir-138 (MIRT005691), hsa-mir-122 (MIRT000364)

    OriGene 3'-UTR Clone: IGF1R
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGF1R
    8/185 QIAGEN miScript miRNA Assays for microRNAs that regulate IGF1R (see all 185):
    hsa-miR-194* hsa-miR-411* hsa-miR-140-5p hsa-miR-631 hsa-miR-376b hsa-miR-605 hsa-miR-3653 hsa-miR-409-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of IGF1R Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGF1R (see all 7)
    OriGene shRNA RFP: IGF1R
    OriGene siRNA: IGF1R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGF1R

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IGF1R

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGF1R (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGF1R (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IGF1R (NM_000875)
    Sino Biological Human cDNA Clone for IGF1R
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGF1R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF1R 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IGF1R
    Search LifeMap BioReagents cell lines for IGF1R

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF1R

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0004713protein tyrosine kinase activity IDA11162456
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0005010insulin-like growth factor-activated receptor activity IDA7679099
    GO:0005158insulin receptor binding IDA8452530


    IGF1R for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for IGF1R:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death HMECs cel  Increased colony dispersion (i 
     Weaker migration 

    Animal Models:
         Mouse knock-outs for IGF1R: Igf1rtm2.1Arge Igf1rtm1.2Mhz Igf1rtm1Mhz Igf1rtm1Arge
         15/22 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Igf1r) (see all 22):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    IGF1R for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IGF1R gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/56 super-pathways (see all 56) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/13 pathways (see all 13)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4Development IGF-RI signaling
    		Development IGF-RI signaling1.00
    		Signal transduction_AKT signaling0.49
    		Development_IGF-1 receptor signaling0.99
    		Signal transduction AKT signaling0.49
    5Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		RhoA Pathway0.35
    		Actin Nucleation and Branching0.66
    		CDC42 Pathway0.34

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/13 EMD Millipore Pathways for IGF1R (see all 13)
        Transcription Androgen Receptor nuclear signaling
    Signal transduction PTEN pathway
    Transcription CREB pathway
    Development Ligand-independent activation of ESR1 and ESR2
    G-protein signaling RhoA regulation pathway

    5/61 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IGF1R (see all 61)
        Nuclear Receptor Activation by Vitamin-A
    RhoA Pathway
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis

    2 Cell Signaling Technology (CST) Pathways for IGF1R
        Tyrosine Kinases / Adaptors
    Glucose / Energy Metabolism

    5 Tocris Bioscience Pathways for IGF1R
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    mTOR Pathway

    5/13 GeneGo (Thomson Reuters) Pathways for IGF1R (see all 13)
        Transcription Androgen Receptor nuclear signaling
    Apoptosis and survival Caspase cascade
    Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction AKT signaling

    5/13 BioSystems Pathways for IGF1R (see all 13) 
        MicroRNAs in cardiomyocyte hypertrophy
    Signaling Pathways in Glioblastoma
    Focal Adhesion
    Apoptosis
    Senescence and Autophagy

    5        Reactome Pathways for IGF1R
        Signal Transduction
    IGF1R signaling cascade
    IRS-related events triggered by IGF1R
    SHC-related events triggered by IGF1R
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)


    5/10         Kegg Pathways  (Kegg details for IGF1R) (see all 10):
        Oocyte meiosis
    Endocytosis
    Focal adhesion
    Adherens junction
    Long-term depression


    IGF1R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGF1R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/171 Interacting proteins for IGF1R (P080691, 2, 3 ENSP000002680354) via UniProtKB, MINT, STRING, and/or I2D (see all 171)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF12Q9NZN52, 3, ENSP000003809424MINT-1774956 MINT-1774857 MINT-1774918 MINT-1774802 MINT-1774883 MINT-1774936 MINT-1774976 I2D: score=3 STRING: ENSP00000380942
    CSKP412402, 3, ENSP000002200034MINT-8029130 MINT-8032913 MINT-8032928 MINT-8029145 MINT-8032898 MINT-8029115 I2D: score=5 STRING: ENSP00000220003
    YWHAEP622582, 3, ENSP000002643354MINT-18626 MINT-18625 MINT-18624 MINT-8005112 I2D: score=5 STRING: ENSP00000264335
    PTPN11Q061242, 3, ENSP000003409444MINT-8029070 MINT-8029025 MINT-8029055 I2D: score=4 STRING: ENSP00000340944
    PIK3R1P279862, 3, ENSP000002743354MINT-8029014 MINT-8029040 MINT-8028998 I2D: score=3 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006955immune response IMP16886151
    GO:0007165signal transduction TAS3003744
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0007409axonogenesis IEA--


    IGF1R for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGF1R gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGF1R for compounds           About GeneDecksing

    EMD Millipore small molecules for IGF1R:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for IGF1R

    Compounds for IGF1R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PicropodophyllotoxinSelective IGF1R inhibitor[477-47-4]
    Demethylasterriquinone B1Selective insulin RTK activator[78860-34-1]
    PQ 401IGF1R inhibitor[196868-63-0]
    Insulin (human) recombinant expressed in yeastEndogenous peptide agonist[11061-68-0]

    2 HMDB Compounds for IGF1R    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    9 DrugBank Compounds for IGF1R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Mecasermin-- 68562-41-4targetagonist8282084 19198769 17139284 1316909 11752352 17016423 12845531 12387515
    Insulin, porcine-- 9004-14-2target--9582514 7476290 17016423 17139284 9846170
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423
    Insulin recombinant-- 9004-10-8target--17139284 17016423
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423
    (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione-- --target--10592235
    3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE-- --target--10592235
    Insulin Glargine-- 160337-95-1targetagonist20392809
    Insulin Lispro-- 133107-64-9target--20392809

    10/129 Novoseek chemical compound relationships for IGF1R gene (see all 129)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ag 1024 89.1 37 19166817 (2), 15613453 (2), 16752221 (1), 18635919 (1) (see all 21)
    tyrosine 79.5 333 8593783 (5), 18263593 (4), 1322128 (4), 1311242 (3) (see all 99)
    mannose 6-phosphate 72.3 30 7588242 (4), 7957246 (2), 8188767 (2), 1657932 (2) (see all 21)
    phosphatidylinositol 71.4 52 1317864 (5), 1311242 (3), 9524259 (1), 10203689 (1) (see all 37)
    podophyllotoxin 62.5 31 18070930 (5), 20150364 (3), 20200966 (1), 17828296 (1) (see all 10)
    ly294002 60.9 3 12460191 (1), 20200966 (1), 12204896 (1)
    estrogen 60.7 101 10749889 (6), 10967123 (3), 11431145 (2), 17138646 (2) (see all 61)
    ascorbyl stearate 58.9 4 11763418 (2), 12645815 (1)
    thymidine 54.6 15 2164527 (1), 10036618 (1), 11924572 (1), 1483875 (1) (see all 12)
    rapamycin 54.5 43 18630505 (3), 19789339 (3), 20486173 (2), 17001314 (2) (see all 22)

    Search CenterWatch for drugs/clinical trials and news about IGF1R 

    Transcripts
    for IGF1R gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IGF1R gene (2 alternative transcripts): 
    NM_000875.3  NM_152452.1  

    Unigene Cluster for IGF1R:

    Insulin-like growth factor 1 receptor
    Hs.643120  [show with all ESTs]
    Unigene Representative Sequence: AB425196
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268035(uc002bul.3 uc010bon.3 uc010boo.1) ENST00000558762(uc010urq.2)
    ENST00000559925(uc010urr.1) ENST00000558355 ENST00000557938 ENST00000560186
    ENST00000560277 ENST00000557873 ENST00000558898 ENST00000560432 ENST00000558947
    ENST00000559582 ENST00000560144 ENST00000561049 ENST00000560343 ENST00000560972
    ENST00000558751

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IGF1R
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGF1R
    8/185 QIAGEN miScript miRNA Assays for microRNAs that regulate IGF1R (see all 185):
    hsa-miR-194* hsa-miR-411* hsa-miR-140-5p hsa-miR-631 hsa-miR-376b hsa-miR-605 hsa-miR-3653 hsa-miR-409-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		EMD Millipore RNAi Products for the Analysis of IGF1R Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGF1R (see all 7)
    OriGene shRNA RFP: IGF1R
    OriGene siRNA: IGF1R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGF1R
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGF1R (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGF1R (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IGF1R (NM_000875)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGF1R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF1R 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGF1R
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGF1R
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGF1R
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGF1R

    Additional cDNA sequence: 

    AB425196.1 AK310188.1 AY429545.1 BC010607.1 BC078157.1 BC088377.1 BC107089.1 BC111046.1 
    BC113610.1 BC113612.1 BC143721.1 EU826611.1 EU826612.1 U09023.1 X04434.1 

    12 DOTS entries:

    DT.444626  DT.456085  DT.97771501  DT.100026379  DT.100754588  DT.100720157  DT.121017124  DT.121017036 
    DT.121017096  DT.99953925  DT.102837299  DT.95081321 

    24/113 AceView cDNA sequences (see all 113):

    CA946716 AW269425 AI658710 BU948608 AW612405 BM677747 AU141484 AI369152 
    AI375882 R35104 BQ417379 AI687898 BX950968 CA946988 AW612013 BM695198 
    AI971190 BU581180 BE328099 BE677810 AI369383 BM129719 AI458627 BX093045 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for IGF1R (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:              -     -     -     -     -     -                                                     -                                   -                 -   
    SP2:                                                                                                                                                            
    SP3:                                -     -     -                                                                                                               
    SP4:                          -     -     -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b
    SP1:                                                                    -               
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for IGF1R

    Expression
    for IGF1R gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGF1R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTAAGTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IGF1R expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/17 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 17) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneCaudal Endochondral BonesEndochondral OsteoblastsBone
    BoneCaudal Endochondral BonesEndochondral PreosteoblastsBone
    BoneEndochondral Facial BonesEndochondral OsteoblastsBone
    BoneEndochondral Facial BonesEndochondral PreosteoblastsBone
    BoneRostral Endochondral Facial BonesEndochondral OsteoblastsBone
    BoneRostral Endochondral Facial BonesEndochondral PreosteoblastsBone
    BoneAutopod PeriosteumImmature Endochondral OsteoblastsBone
    BoneCervical VertebraeImmature Endochondral OsteoblastsBone
    BoneLumbar VertebraeImmature Endochondral OsteoblastsBone
    BoneSacral VertebraeImmature Endochondral OsteoblastsBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IGF1R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGF1R

    SOURCE GeneReport for Unigene cluster: Hs.643120

    UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
    Tissue specificity: Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle,
    hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in
    tumors, including melanomas, cancers of the colon, pancreas prostate and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including IGF1R (see all 13): 
              Osteogenesis in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Apoptosis in human mouse rat
              Cell Motility in human mouse rat
              Cancer Drug Targets in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGF1R
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGF1R
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGF1R
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGF1R
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF1R

    Orthologs
    for IGF1R gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for IGF1R gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IGF1R1 insulin-like growth factor 1 receptor 79.26(n)
    84.99(a)    		   395889  NM_205032.1  NP_990363.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IGF1R6
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343383.1(49242-208963)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3980222 insulin-like growth factor-1 receptor beta subunit 74.91(n)    AF055980.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii igf1ra2 insulin-like growth factor 1a receptor 76.93(n)   245701  AF400275.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sev3
    InR1    		 R7 cell fate commitment protein tyrosine
    kinase3
    Insulin-like receptor1    		 49(a)
    (best of 5)3
    50.61(n)1
    42.47(a)1    		   1 10A43
    425491  NM_001144622.11  NP_001138094.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea R151.43
    daf-21    		 Tyrosine kinase3
    Protein DAF-21    		 38(a)
    (best of 8)3
    44.64(n)1
    34.94(a)1    		   III(7291720-7292812)3
    1754101  NM_065249.31  NP_497650.31 


    ENSEMBL Gene Tree for IGF1R (if available)
    TreeFam Gene Tree for IGF1R (if available) 

    Paralogs
    for IGF1R gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGF1R gene
    INSR2  ROR12  ROS12  LTK2  NTRK22  DDR12  NTRK32  ROR22  
    INSRR2  DDR22  MUSK2  ALK2  NTRK12  
    18/28 SIMAP similar genes for IGF1R using alignment to 7 protein entries:     IGF1R_HUMAN (see all proteins) (see all similar genes):
    RET    INSRR    INSR    MET    ABL1    DKFZp434L0319
    EPHA2    FES    PTK6    tec    KIT    SLC34A2/ROS1 fusion
    BTK kinase deficient isoform 6    FGFR3    FGFR1    FGR    BTK kinase deficient isoform 2    RYK

    IGF1R for paralogs           About GeneDecksing



    Genomic Variants
    for IGF1R gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6480 NCBI SNPs in IGF1R are shown (see all 6480)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs339581761,2
    		C,F,pathogenic81455171(+) GCACCG/AGTACC 2 /Q /R mis111Minor allele frequency- A:0.00NA EU CSAM EA 6263
    rs357078921,2
    		F--75318883(+) GGCTGC/ACCTCC 1 -- us2k15Minor allele frequency- A:0.03NA EU CSAM EA 380
    rs355540271,2
    		C,--75319052(+) TTCCCC/GCTCCG 1 -- us2k18Minor allele frequency- G:0.36NA EU CSAM EA WA 620
    rs350418621,2
    		C--75320442(+) CTCTCG/CCTCTG 2 /S syn16Minor allele frequency- C:0.01NA EU CSAM EA 382
    rs129056811,2
    		C--75320989(+) GGGGGC/GAGGTG 1 -- int1 trp30--------
    rs284097681,2
    		C,F,--75321084(+) GGGCTC/TCTCGG 1 -- int13Minor allele frequency- T:0.15NS WA EA 400
    rs129059981,2
    		C--75321152(+) GTCCCA/GGGGCT 1 -- int10--------
    rs414492481,2
    		C,F,--75321328(+) AGGGCC/TGCATC 1 -- int18Minor allele frequency- T:0.02NS NA 630
    rs734734131,2
    		C,--75321461(+) CGTACG/CCTGTG 1 -- int12Minor allele frequency- C:0.05WA 120
    rs740353091,2
    		C,--75322027(+) CAAATC/TCTTAA 1 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for IGF1R (99192200 - 99442200 bp, first 250kb of IGF1R)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for IGF1R
         1 CNV: 66891
         2 Indels: 11105 11104
    Human Gene Mutation Database (HGMD): IGF1R

    Locus Specific Mutation Databases (LSDB): IGF1R

    SABiosciences Cancer Mutation PCR Assays
    3 SABiosciences qBiomarker Copy Number PCR Arrays containing IGF1R:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    Kinases & Phosphatases
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGF1R
    DNA2.0 Custom Variant and Variant Library Synthesis for IGF1R

    Disorders / Diseases
    for IGF1R gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGF1R for disorders           About GeneDecksing

    OMIM gene information: 147370   
    OMIM disorders: 270450  
    UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
  • Defects in IGF1R are a cause of insulin-like growth factor 1 resistance (IGF1RES) [MIM:270450]. It is a
    • disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma
    IGF1

    20/180 diseases for IGF1R (see all 180):    About MalaCards
    donohue syndrome    insulin resistance    insulin-like growth factor 1 resistance to    beckwith-wiedemann syndrome
    rabson-mendenhall syndrome    acanthosis nigricans    atypical teratoid rhabdoid tumor    ring chromosome 15
    intrauterine and postnatal growth retardation    skeletal muscle regeneration    silver-russell syndrome    ring chromosomes
    age related macular degeneration    polycythemia vera    renal clear cell carcinoma    nijmegen breakage syndrome
    short stature    polycystic ovary syndrome    rhabdoid tumors    growth hormone deficiency

    7 diseases from the University of Copenhagen DISEASES database for IGF1R:
    Breast cancer     Sarcoma     Lung cancer     Peripheral primitive neuroectodermal tumor
    Carcinoma     Prostate cancer     Colorectal cancer

    10/93 Novoseek disease relationships for IGF1R gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    igf-i resistance 82.9 7 1437400 (1), 8077364 (1), 15476454 (1), 1386373 (1) (see all 7)
    breast cancer 66.9 243 15687676 (7), 17210722 (6), 15619214 (4), 15987464 (3) (see all 99)
    tumors 65.7 415 20486173 (5), 17651787 (5), 11550306 (4), 10446966 (4) (see all 99)
    leprechaunism 63.8 1 9003010 (1)
    cancer 60.2 259 17393577 (4), 17651787 (4), 15956962 (4), 15566314 (4) (see all 99)
    ewings sarcoma 59.2 24 16740780 (4), 1315779 (2), 11896447 (2), 19840522 (1) (see all 13)
    osteosarcoma 52.3 40 19229591 (6), 20486173 (4), 15738602 (2), 10453987 (1) (see all 19)
    prostate cancer 51.6 100 12019176 (6), 17065200 (5), 12581018 (4), 15499378 (4) (see all 47)
    rhabdomyosarcoma 48 11 8083365 (3), 18829562 (1), 11807989 (1), 9537584 (1) (see all 5)
    growth retardation 46.7 22 20103656 (2), 16151622 (1), 15476454 (1), 15384084 (1) (see all 16)

    Genetic Association Database (GAD): IGF1R
    Human Genome Epidemiology (HuGE) Navigator: IGF1R (84 documents)
    Tumor Gene Database (TGDB): IGF1R

    Export disorders for IGF1R gene to outside databases

    Publications
    for IGF1R gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGF1R gene, integrated from 9 sources (see all 1889):
    (articles sorted by number of sources associating them with IGF1R)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Insulin-like growth factor I receptor gene structure. (PubMed id 1316909)1, 2, 3, 7 Abbot A.M.... Smith R.J. (1992)
    2. IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. (PubMed id 14657428)1, 2, 4, 9 Abuzzahab M.J.... Chernausek S.D. (2003)
    3. Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. (PubMed id 12019176)1, 2, 9 Hellawell G.O....Macaulay V.M. (2002)
    4. Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. (PubMed id 12821780)1, 2, 9 Girnita L....Larsson O. (2003)
    5. {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. (PubMed id 15878855)1, 2, 9 Girnita L.... Larsson O. (2005)
    6. Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor. (PubMed id 18566589)1, 2, 9 Wu J....Hubbard S.R. (2008)
    7. Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. (PubMed id 16831875)1, 2, 9 Slaaby R.... Brandt J. (2006)
    8. Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study. (PubMed id 15127203)1, 4, 9 Laukkanen O....Laakso M. (2004)
    9. Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. (PubMed id 12843179)1, 4, 9 Bonafe M....Paolisso G. (2003)
    10. Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). (PubMed id 7679099)1, 2, 9 Kato H.... LeRoith D. (1993)

    External Searches for IGF1R gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing IGF1R gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3480 HGNC: 5465 AceView: IGF1R Ensembl:ENSG00000140443 euGenes: HUgn3480
    ECgene: IGF1R Kegg: 3480 H-InvDB: IGF1R

    Other Databases showing IGF1R gene

    (According to HUGE)
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    Specialized Databases showing IGF1R gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGF1R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGF1R Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igf1r/
    Wikipedia http://en.wikipedia.org/wiki/IGF-1_receptor

    Intellectual Property
    for IGF1R gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGF1R gene:
    Search GeneIP for patents involving IGF1R

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