V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

IGF1R Gene

protein-coding   GIFtS: 76

GC15P097010
insulin-like growth factor 1 receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for IGF1R

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CD221 1, 2
EC 2.7.10.1 3
IGFIR 1, 2
IGFR 1, 2
JTK13 1, 2
MGC142170 2
MGC142172 2
MGC18216 1, 2
Descriptions
CD221 antigen 3
IGF-I receptor 3
Insulin-like growth factor I receptor 3
insulin-like growth factor 1 receptor 2
soluble IGF1R variant 1 2
soluble IGF1R variant 2 2
External Ids
HGNC: 54651
Entrez Gene: 34802
UniProtKB: P080693
Ensembl: ENSG000001404437
Search outside databases for aliases for IGF1R gene

Previous GC identifers: GC15P095878 GC15P093033 GC15P096785 GC15P096928

Summaries
for IGF1R

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for IGF1R:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase
activity. The insulin-like growth factor I receptor plays a critical role in transformation
events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in
most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
[provided by RefSeq]

UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
Function: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2
with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the
activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor
with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR
isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not
significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform
Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid
receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR
isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for
insulin

Gene Wiki entry for IGF1R (Insulin-like_growth_factor_1_receptor)

Genomic Location
for IGF1R

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IGF1R gene  

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

IGF1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P097010:     (about GC identifiers)

Start:
 97,010,284 bp from pter
End:
 97,325,282 bp from pter
Size:
 314,999 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000015.8  NT_035325.6  

Proteins
for IGF1R

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069 (See protein sequence)
Recommended Name: Insulin-like growth factor 1 receptor precursor  
Size: 1367 amino acids; 154793 Da
Subunit: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains
contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase
domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when
autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a
tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain
of IGF1R
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :
1IGR (3D)    1JQH (3D)    1K3A (3D)    1M7N (3D)    1P4O (3D)    2OJ9 (3D)    2ZM3 (3D)    3D94 (3D)    
3F5P (3D)    
Secondary accessions: B1B5Y2 Q14CV2 Q9UCC0

Post-translational modifications:

  • The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response
    to insulin-like growth factor I (IGF I)1
  • Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_000866.1  

    ENSEMBL proteins: 
    ENSP00000268035 


    Human Recombinant Proteins 
    Invitrogen human recombinant proteins for IGF1R
    Millipore Purified and/or Recombinant IGF1R Protein
    Sigma-Aldrich Proteins for IGF1R  
    R&D Systems Recombinant & Natural Proteins for IGF1R (IGF-I R)
    Enzo Life Sciences proteins for IGF1R
    Recombinant Proteins from Abcam (IGF1 Receptor alpha subunit, IGF1 Receptor beta subunit, IGF1 Receptor)
    Human Recombinant Proteins from Abnova (IGF1R)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005792 microsome IDA8452530
    GO:0005887 integral to plasma membrane IC7679099
    GO:0016020 membrane IEA--
    About this table

    Antibodies for IGF1R: 
    Invitrogen Antibodies for IGF1R
    Millipore Mono- and Polyclonal Antibodies for the study of IGF1R
    Sigma-Aldrich Antibodies for IGF1R
    R&D Systems Antibodies for IGF1R (IGF-I R)
    Cell Signaling Technology (CST) Antibodies for IGF1R  (IGF-1R)
    Antibodies from Abcam (IGF1 Receptor alpha subunit, IGF1 Receptor beta subunit, IGF1 Receptor), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (IGF1R)
    Novus Biologicals Antibodies for IGF1R

    Assays for IGF1R: 
    Invitrogen Assays for IGF1R
    Millipore Kits and Assays for the Analysis of IGF1R
    R&D Systems ELISAs for IGF1R (IGF-I R)         (see all)
    Cell Signaling Technology (CST) Sandwich ELISA Kits for IGF1R (IGF-1R)
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for IGF1R

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/11 InterPro domains/families (see all 11 ):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR000494 EGF_rcpt_L
     IPR016246 Insulin_rcpt
     IPR008957 Fibronectin_typ-III-like_fold


       GeneDecks  IGF1R for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P08069

    ProtoNet protein and cluster: P08069

    5/6 Blocks protein families (see all 6 ):
    IPB000463 Cytosolic fatty-acid binding protein
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB002011 Receptor tyrosine kinase
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor
    subfamily
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain

    Gene Function
    for IGF1R

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (IGF1R)
    Millipore RNAi Products for the Analysis of IGF1R Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (IGF1R)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000875

                  Applied Biosystems Silencer® siRNAs for IGF1R

                  Sigma-Aldrich siRNA and siRNA Panels for IGF1R  
                         Sigma-Aldrich shRNA Panels and shRNA for IGF1R  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for IGF1R
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000875
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000875
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000875 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000875

    UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
    Function: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2
    with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the
    activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor
    with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR
    isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not
    significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform
    Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid
    receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR
    isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for
    insulin
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Autophosphorylation activates the kinase activity
    Enzyme Number (IUBMB): EC 2.7.10.1 

    Genatlas biochemistry entry for IGF1R:
    insulin-like growth factor 1,receptor

    15/24 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Igf1r) (see all 24 ):

    adipose tissuebehavior/neurologicalcellularcraniofacial
    digestive/alimentaryembryogenesisgrowth/sizehematopoietic systemhomeostasis/metabolism
    immune systemlethality-postnatallethality-prenatal/perinatallife span-post-weaning/aginglimbs/digits/tail

    5/11 Gene Ontology (GO) molecular function terms (links to tree view) (see all 11 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004872 receptor activity IEA--
    GO:0005010 insulin-like growth factor receptor activity IDA7679099
    GO:0005158 insulin receptor binding IDA8452530
    GO:0005524 ATP binding IEA--
    About this table

    Pathways & Interactions
    for IGF1R

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/11 Invitrogen iPath™ Online BioAtlas - Pathways for IGF1R (see all 11 ) (Maps provided by GeneGo):
     PTEN pathway
     Pleckstrin homology proteins interactions. Part VIII
     Caspases cascade
     Cell Cycle Regulation by Brca1
     IGF-RI signaling

       GeneDecks  IGF1R for the pathways selected above  
    About GeneDecksing

    5/13 Millipore Pathways for IGF1R (see all 13 )
     Transcription Androgen Receptor nuclear signaling
     Signal transduction PTEN pathway
     Transcription CREB pathway
     Development Ligand-independent activation of ESR1 and ESR2
     G-protein signaling RhoA regulation pathway

       GeneDecks  IGF1R for the pathways selected above  
    About GeneDecksing

    5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for  IGF1R  (Your Favorite Gene powered by Ingenuity) (see all 7 ) 
     Cardiac Hypertrophy Signaling
     Glioma Signaling
     Synaptic Long Term Depression
     Hepatic Fibrosis / Hepatic Stellate Cell Activation
     Huntington's Disease Signaling

       GeneDecks  IGF1R for the pathways selected above  
    About GeneDecksing

    2 Cell Signaling Technology (CST) Pathways for IGF1R: 
     Translational Control: Regulation of eIF4E and p70 S6 Kinase
     Protein Acetylation

       GeneDecks  IGF1R for the pathways selected above  
    About GeneDecksing

    5/8 Kegg Pathways  (Kegg details for IGF1R) (see all 8 ):
     hsa04510 Focal adhesion
     hsa04520 Adherens junction
     hsa04730 Long-term depression
     hsa05200 Pathways in cancer
     hsa05210 Colorectal cancer

       GeneDecks  IGF1R for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  IGF1R 


    5/202 Interacting proteins for IGF1R (ENSP000002680353 P080691, 2) via UniProtKB, MINT, and/or STRING (see all 202 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF12Q9NZN52STRING (score=.909) MINT-1774956 MINT-1774857 MINT-1774918 MINT-1774802 MINT-1774883 MINT-1774936 MINT-1774976
    PTPN1P180312STRING (score=.998) MINT-6764717 MINT-6764963 MINT-6800783
    YWHAEP622582STRING (score=.872) MINT-18626 MINT-18625 MINT-18624
    GRB10Q133222STRING (score=.999) MINT-15643 MINT-15644
    IRS2Q9Y4H22STRING (score=.997) MINT-17857 MINT-18053
    About this table

    5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006916 anti-apoptosis TAS8710868
    GO:0006955 immune response IMP16886151
    GO:0007165 signal transduction TAS3003744
    GO:0007420 brain development IEA--
    GO:0008284 positive regulation of cell proliferation TAS10749889
    About this table

    Drugs & Compounds
    for IGF1R

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for IGF1R
    Sigma-Aldrich Small Molecules for IGF1R:
    Inhibitor

    Compounds for IGF1R available from Tocris Bioscience
    CompoundAction CAS number
    PicropodophyllotoxinSelective IGF1R inhibitor[477-47-4]
    Demethylasterriquinone B1Selective insulin RTK activator[78860-34-1]
    PQ 401IGF-IR inhibitor[196868-63-0]
    Insulin (human) recombinantEndogenous peptide agonist[11061-68-0]
    About this table


    10/49 Novoseek chemical compound relationships for IGF1R gene (see all 49 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    ag 1024 87.82 30 19166817 (2), 15613453 (2), 16752221 (1), 18635919 (1) (see all 16)
    tyrosine 78.84 289 8593783 (5), 18263593 (4), 1322128 (4), 1311242 (3) (see all 99)
    phosphatidylinositol 71.50 50 1317864 (5), 1311242 (3), 9524259 (1), 10203689 (1) (see all 35)
    mannose 6-phosphate 71.49 28 7588242 (4), 7957246 (2), 8188767 (2), 1657932 (2) (see all 20)
    ascorbyl stearate 60.04 4 11763418 (2), 12645815 (1)
    thymidine 54.93 14 2164527 (1), 10036618 (1), 11924572 (1), 1483875 (1) (see all 11)
    wortmannin 54.39 4 9774684 (1), 10203689 (1)
    pd 98,059 48.90 1 12204896 (1)
    phosphotyrosine 48.51 6 1322128 (2), 12551896 (1), 9736716 (1), 19016246 (1) (see all 5)
    17-(allylamino)-17-demethoxygeldanamycin 41.58 5 18594209 (1), 14729636 (1), 17975158 (1)
    About this table


    Transcripts
    for IGF1R

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (IGF1R)
    Millipore RNAi Products for the Analysis of IGF1R Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (IGF1R)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000875

                  Sigma-Aldrich siRNA and siRNA Panels for IGF1R  
                         Sigma-Aldrich shRNA Panels and shRNA for IGF1R  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000875  

    REFSEQ mRNAs for IGF1R gene: 

    NM_000875.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000875  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000875
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000875
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000875 

    Additional cDNA sequence: 

    AB425196.1 AK310188.1 AY429545.1 BC010607.1 BC078157.1 BC088377.1 BC107089.1 BC111046.1 
    BC113610.1 BC113612.1 BC143721.1 CR624013.1 EU826611.1 EU826612.1 U09023.1 X04434.1 

    11 DOTS entries:

    DT.444626  DT.456085  DT.97771501  DT.100026379  DT.100754588  DT.100720157  DT.121017036  DT.121017096 
    DT.99953925  DT.102837299  DT.95081321 

    24/113 AceView cDNA sequences (see all 113 ):

    AI375882 BM129719 R35104 AI458627 AU141484 BQ417379 AW269425 BM695198 
    AW612405 AI369152 BM677747 AI687898 CA946716 BU581180 BE328099 BX950968 
    CA946988 BX093045 AI369383 AI658710 AW612013 AI971190 BE677810 BU948608 

    highest scoring ESTs for IGF1R:

    X04434 AA146696 AA155689 AA256419 AA319205 AA907942 AI830698 AI916305 AU124169 AU141484 

    Unigene Cluster for IGF1R:

    Insulin-like growth factor 1 receptor
    Hs.643120  [show with all ESTs]
    Unigene Representative Sequence: AB425196


    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for IGF1R (see all 12 )

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:              -     -     -     -     -     -                                                     -                                   -                 -   
    SP2:                                                                                                                                                            
    SP3:                                -     -     -                                                                                                               
    SP4:                          -     -     -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b
    SP1:                                                                    -               
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for IGF1R

    1 Ensembl transcript including schematic representation:
    ENST00000268035  

    Expression
    for IGF1R

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    IGF1R expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for IGF1R

    1 / 2 / 3

    16 probe-sets matching IGF1R gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    64083_at2, 3 U95-C 1 1.00 1.00 0.79 1.68 AL044092 0.40 0.50 0.45 1

    		34718_at2, 3 U95-A 1 1.00 1.00 0.87 0.79 X04434 1.00 1.00 1.00 1

    		31335_at2, 3 U95-A 1 1.00 1.00 -0.16 0.93 AF020763 0.60 1.00 0.82 1
    64981_at2, 3 U95-C 1 1.00 1.00 0.93 1.20 AA188197 0.40 0.50 0.45 1
    60450_at2, 3 U95-C 1 1.00 1.00 0.61 0.93 AI916305 0.80 1.00 0.91 1

    		1335_at2, 3 U95-A 1 1.00 1.00 0.79 0.51 X04434 1.00 1.00 1.00 1

    		225330_at2, 3 U133-B 1 1.00 1.00 -- -- AL044092 0.40 0.50 0.45 1

    		208441_at2, 3 U133-A 1 1.00 1.00 -- -- NM_015883 0.20 1.00 0.72 1

    		203627_at2, 3 U133-A 1 1.00 1.00 -- -- AI830698 0.80 1.00 0.91 1

    		203628_at2, 3 U133-A 1 1.00 1.00 -- -- H05812 0.40 1.00 0.76 1

    		243358_at2, 3 U133-B 1 0.91 1.00 -- -- BF347362 0.20 0.50 0.38 1

    		225330_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		208441_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		203627_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		203628_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		243358_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    GeneDecks  IGF1R for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCAAATTATG

    SOURCE GeneReport for Unigene cluster: Hs.643120

    Expression variation in blood from EXPOLDB for IGF1R

    UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
    Tissue specificity: Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue,
    skeletal muscle, hepatoma, fibrobasts, spleen and placenta (at protein level). Expressed in a
    variety of tissues

    Orthologs
    for IGF1R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for IGF1R gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 IGF1R1   -- insulin-like growth factor 1 receptor 91.68(n)
    98.24(a)    		 442951  XM_853347.1  XP_858440.1 
    chimpanzee
    (Pan troglodytes)    		 IGF1R1   -- insulin-like growth factor 1 receptor 99.41(n)
    99.78(a)    		 453676  XM_001136377.1  XP_001136377.1 
    cow
    (Bos taurus)    		 IGF1R1   -- insulin-like growth factor 1 receptor 91.25(n)
    97.75(a)    		 281848  XM_606794.3  XP_606794.3 
    rat
    (Rattus norvegicus)    		 Igf1r1   -- insulin-like growth factor 1 receptor 89.5(n)
    96.12(a)    		 25718  NM_052807.1  NP_434694.1 
    mouse
    (Mus musculus)    		 Igf1r1, 5 7 (33.00 cM)5
    		 insulin-like growth factor I receptor1, 5 89.56(n)1
    96.12(a)1    		 160011  NM_010513.21  NP_034643.21 
     AA1167315  AB0064425  (see all 31)
    About this table        Species with no ortholog for IGF1R

    ENSEMBL Gene Tree for IGF1R

    Paralogs
    for IGF1R

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for IGF1R gene
    INSR2  INSRR2  

    SNPs/Variants
    for IGF1R

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/2492 NCBI SNPs in IGF1R are shown (see all 2492 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 730)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs26549811,2
    		A,C,F,H97322652(+) TGGTAG/CGAAAA 1 -- ut3112Minor allele frequency- C:0.48EU EA WA 1258
    rs18150091,2
    		A,C,F,H97322194(-) GTAAAA/GTGACT 1 -- ut3112Minor allele frequency- G:0.45EU EA WA NA 1048
    rs20163471,2
    		A,C,F,H97321323(-) CAATGA/CCCCAC 1 -- ut3118Minor allele frequency- N:0.01EA MN CSAM NA EU WA 2940
    rs26847881,2
    		A,C,F,H97321960(-) AGGCCA/GTTATT 1 -- ut317Minor allele frequency- G:0.45NA EU EA WA 558
    rs7024971,2
    		A,C,F,H97319104(+) AGCAGC/TCTGGC 1 -- ut317Minor allele frequency- T:0.19NA MN EU EA WA NS 804
    rs20168731,2
    		C,F,H97319281(+) AAAGCA/GGTCAA 1 -- ut3111Minor allele frequency- G:0.08NA EA MN EU WA 968
    rs26847871,2
    		C,F,H97322585(-) AACACG/AGTCTT 1 -- ut314Minor allele frequency- A:0.12EU EA WA 416
    rs21770311,2
    		C,F,H97324465(-) AATCAA/GTCATG 1 -- ut318Minor allele frequency- G:0.01EU EA WA 838
    rs20028801,2
    		C,F,H97321268(-) CCTTCC/TTCTCC 1 -- ut3112Minor allele frequency- T:0.02EU EA WA MN CSAM NA 938
    rs25930301,2
    		A,C,H97325445(+) ATGCAA/GATTGC 1 -- ng313Minor allele frequency- G:0.00EU EA 300
    About this table

    HapMap Linkage Disequilibrium images for IGF1R (up to first 250kb)

    Disorders & Mutations
    for IGF1R

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 147370   disorders: 270450  

    UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069

  • Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor
    1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by
    intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1

    • 10/95 Novoseek disease relationships for IGF1R gene (see all 95 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    igf-i resistance 82.95 5 1437400 (1), 8077364 (1), 15476454 (1), 1386373 (1) (see all 5)
    breast cancer 66.38 210 15687676 (7), 17210722 (6), 15619214 (4), 15987464 (3) (see all 99)
    leprechaunism 65.13 1 9003010 (1)
    tumors 63.21 347 17651787 (5), 11550306 (4), 10446966 (4), 18678349 (4) (see all 99)
    cancer 57.09 214 17393577 (4), 17651787 (4), 15956962 (4), 15566314 (4) (see all 99)
    prostate cancer 50.56 86 12019176 (6), 17065200 (5), 12581018 (4), 15499378 (4) (see all 41)
    osteosarcoma 49.78 21 15738602 (2), 10453987 (1), 15969240 (1), 2153840 (1) (see all 16)
    ewings sarcoma 49.74 19 16740780 (4), 1315779 (2), 11896447 (2), 14648701 (1) (see all 9)
    growth retardation 47.14 19 16151622 (1), 15476454 (1), 15384084 (1), 10098523 (1) (see all 14)
    short stature 44.27 11 19240156 (2), 1437400 (1), 8287588 (1), 8964861 (1) (see all 8)
    About this table

    Human Gene Mutation Database: IGF1R
    Genetic Association Database: IGF1R
    Human Genome Epidemiology Navigator: IGF1R (34 documents)
    Tumor Gene Database: IGF1R
    Breast Cancer Gene Database: IGF1R

    Medical News
    for IGF1R

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for IGF1R

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/1457 PubMed articles for IGF1R gene (see all 1457 ):

    Search for IGF1R

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IGF1R

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 3480 HGNC: 5465 AceView: IGF1R Ensembl:ENSG00000140443 euGenes: HUgn3480
    ECgene: IGF1R H-InvDB: IGF1R

    Other Databases showing IGF1R

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing IGF1R

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for IGF1R Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igf1r/

    Licensable Technologies
    for IGF1R

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for IGF1R

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for IGF1R:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IGF1R-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for IGF1R Antibodies for IGF1R
     Explore super-pooled esiRNAs Proteins for IGF1R
     Lentivirus-delivered shRNAs for IGF1R Small molecules for IGF1R
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (IGF1R)
     Antibodies (IGF1R)
     Chimera RNAi (IGF1R)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Antibodies & Assays for IGF1R  (IGF-1R)

     Recombinant Proteins
    (IGF1 Receptor alpha subunit, IGF1 Receptor beta subunit, IGF1 Receptor)
     Antibodies (IGF1 Receptor alpha subunit, IGF1 Receptor beta subunit, IGF1 Receptor)
     Search OriGene for IGF1R
     Tocris compounds for IGF1R




     Drugs/Proteins for IGF1R
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for IGF1R

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    IGF1R Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com