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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGF1R Gene

protein-coding   GIFtS: 80
GCID: GC15P099192

Insulin-Like Growth Factor 1 Receptor

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like Growth Factor 1 Receptor1 2     IGFR2
Insulin-Like Growth Factor I Receptor2 3     JTK132
IGF-I Receptor2 3     Soluble IGF1R Variant 12
EC 2.7.10.13 8     Soluble IGF1R Variant 22
CD2212     CD221 Antigen3
IGFIR2     EC 2.7.108

External Ids:    HGNC: 54651   Entrez Gene: 34802   Ensembl: ENSG000001404437   OMIM: 1473705   UniProtKB: P080693   

Export aliases for IGF1R gene to outside databases

Previous GC identifers: GC15P095878 GC15P093033 GC15P096785 GC15P096928 GC15P097010 GC15P075320


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGF1R Gene:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The
insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor
generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an
anti-apoptotic agent by enhancing cell survival. (provided by RefSeq, Jul 2008)

GeneCards Summary for IGF1R Gene: 
IGF1R (insulin-like growth factor 1 receptor) is a protein-coding gene. Diseases associated with IGF1R include insulin-like growth factor 1 resistance to, and ring chromosome 15, and among its related super-pathways are Signal transduction AKT signaling and Glioma. GO annotations related to this gene include insulin receptor binding and identical protein binding. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
Function: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with
high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth
and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding
activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple
substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc
and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the
PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular
proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.
Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several
downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis
through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation
of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to
recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R
signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT).
Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of
transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity
of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity.
JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via
phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R
Function: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors
composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and
not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are
activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R
and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding
characteristics, both bind IGF1 and have a low affinity for insulin

summary for IGF1R Gene:
Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each
of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular
tyrosine kinase activity. IR homodimers are activated by insulin and in adults, mediate an increase in
glucose uptake through upregulation of Glut4 expression. Two isoforms of the IR exist; fetal IR-A and adult
IR-B. IGF1R homodimers are activated by IGF-I and IGF-II and mediate pre- and postnatal growth. IGF2R
sequesters IGF-II and acts to regulate its levels. IR-IGF1R heterodimers exist and, like IGF1R homodimers,
are activated by IGF-I and IGF-II. IRs and IGFRs mediate their intracellular actions through the PI 3-K and
RAS/RAF/MAPK signaling pathways and downstream effectors include mTOR, p70 S6 kinase, ERK and JNK. Many
tumors have altered expression of IGF1R and its ligands and this constitutes an early, possible initiating,
event in tumorigenesis. Decreases in IR signaling causing insulin resistance is a major component in the
development of type 2 diabetes and congenital mutations in the IR can cause the fatal Donohue syndrome.

Gene Wiki entry for IGF1R (Insulin-like growth factor 1 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGF1R gene promoter:
         MEF-2A   TBP   STAT1   AP-1   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): IGF1R promoter sequence
   Search SABiosciences Chromatin IP Primers for IGF1R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGF1R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

IGF1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF1R gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P099192:  view genomic region     (about GC identifiers)

Start:
99,192,200 bp from pter      End:
99,507,759 bp from pter
Size:
315,560 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069 (See protein sequence)
Recommended Name: Insulin-like growth factor 1 receptor precursor  
Size: 1367 amino acids; 154793 Da
Subunit: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the
formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and
with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid
receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha
chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with
GNB2L1/RACK1. Interacts with SOCS1, SOCS2 and SOCS3. Interacts with 14-3-3 proteins. Interacts with NMD2.
Interacts with MAP3K5. Interacts with STAT3
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=BAG11657.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/17 PDB 3D structures from and Proteopedia for IGF1R (see all 17):
1IGR (3D)        1JQH (3D)        1K3A (3D)        1M7N (3D)        1P4O (3D)        2OJ9 (3D)    
Secondary accessions: B1B5Y2 Q14CV2 Q9UCC0

Explore the universe of human proteins at neXtProt for IGF1R: NX_P08069

Explore proteomics data for IGF1R at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e.
    one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation
    occurs in a sequential manner; Tyr-1165 is predominantly phosphorylated first, followed by phosphorylation of
    Tyr-1161 and Tyr-1166. While every single phosphorylation increases kinase activity, all three tyrosine residues
    in the kinase activation loop (Tyr-1165, Tyr-1161 and Tyr-1166) have to be phosphorylated for optimal activity.
    Can be autophosphorylated at additional tyrosine residues (in vitro). Autophosphorylated is followed by
    phosphorylation of juxtamembrane tyrosines and C-terminal serines. Phosphorylation of Tyr-980 is required for
    IRS1- and SHC1-binding. Dephosphorylated by PTPN1 (By similarity)
  • UniProtKB: Polyubiquitinated at Lys-1168 and Lys-1171 through both 'Lys-48' and 'Lys-29' linkages, promoting receptor
    endocytosis and subsequent degradation by the proteasome. Ubiquitination is facilitated by pre-existing
    phosphorylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08069

  • 4/43 DME Specific Peptides for IGF1R (P08069) (see all 43)
     LMRMCWQ  DGQDACG  PESLKDG  RDLAARN 

    IGF1R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGF1R Protein Expression
    REFSEQ proteins: NP_000866.1  
    ENSEMBL proteins: 
     ENSP00000268035   ENSP00000453007   ENSP00000453630   ENSP00000454115   ENSP00000456950  
     ENSP00000453180  
    Reactome Protein details: P08069
    Human Recombinant Protein Products for IGF1R: 
    EMD Millipore Purified and/or Recombinant IGF1R Protein
    R&D Systems Recombinant & Natural Proteins for IGF1R (IGF-I R)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IGF1R
    OriGene Protein Over-expression Lysate for IGF1R
    OriGene MassSpec for IGF1R 
    OriGene Custom Protein Services for IGF1R
    GenScript Purified and Recombinant Proteins for IGF1R
    Novus Biologicals IGF1R Proteins
    Novus Biologicals IGF1R Lysates
    Sino Biological Recombinant Protein for IGF1R
    Sino Biological Cell Lysate for IGF1R 
    ProSpec Recombinant Protein for IGF1R
    Cloud-Clone Corp. Proteins for IGF1R 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IC7679099
    GO:0005901caveola IEA--
    GO:0016020membrane IDA8452530
    GO:0016021integral to membrane ----

    IGF1R for ontologies           About GeneDecksing



    IGF1R Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IGF1R
    R&D Systems Antibodies for IGF1R (IGF-I R)
    Cell Signaling Technology (CST) Antibodies for IGF1R 
    OriGene Antibodies for IGF1R
    OriGene Custom Antibody Services for IGF1R
    GenScript Superior Antibodies for IGF1R
    Novus Biologicals IGF1R Antibodies
    Abcam antibodies for IGF1R
    Cloud-Clone Corp. Antibodies for IGF1R 
    ThermoFisher Antibody for IGF1R
    LSBio Antibodies in human, mouse, rat for IGF1R 

    Assay Products for IGF1R: 
    EMD Millipore Kits and Assays for the Analysis of IGF1R
    OriGene Custom Assay Services for IGF1R
    R&D Systems ELISAs for IGF1R (IGF-I R)         (see all)
    GenScript IGF1R-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for IGF1R
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IGF1R 
    Cloud-Clone Corp. CLIAs for IGF1R


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: Insulin-like growth factor I 
    Insulin receptor (InsR) family
    Insulin receptor family

    5/14 InterPro protein domains (see all 14):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR003961 Fibronectin_type3
     IPR011009 Kinase-like_dom
     IPR002011 Tyr_kinase_rcpt_2_CS

    Graphical View of Domain Structure for InterPro Entry P08069

    ProtoNet protein and cluster: P08069

    5/6 Blocks protein domains (see all 6):
    IPB000463 Cytosolic fatty-acid binding protein
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB002011 Receptor tyrosine kinase
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain


    IGF1R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IGF1R_HUMAN, P08069
    Function: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with
    high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth
    and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding
    activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple
    substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc
    and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the
    PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular
    proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.
    Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several
    downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis
    through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation
    of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to
    recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R
    signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT).
    Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of
    transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity
    of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity.
    JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via
    phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R
    Function: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors
    composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and
    not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are
    activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R
    and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding
    characteristics, both bind IGF1 and have a low affinity for insulin
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by autophosphorylation at Tyr-1165, Tyr-1161 and Tyr-1166 on the kinase activation
    loop; phosphorylation at all three tyrosine residues is required for optimal kinase activity. Inhibited by
    MSC1609119A-1, BMS-754807, PQIP, benzimidazole pyridinone, isoquinolinedione, bis-azaindole, 3-cyanoquinoline,
    2,4-bis-arylamino-1,3-pyrimidine, pyrrolopyrimidine, pyrrole-5-carboxaldehyde, picropodophyllin (PPP), tyrphostin
    derivatives. While most inhibitors bind to the ATP binding pocket, MSC1609119A-1 functions as allosteric
    inhibitor and binds close to the DFG motif and the activation loop

         Genatlas biochemistry entry for IGF1R:
    insulin-like growth factor 1,receptor

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0005010insulin-like growth factor-activated receptor activity IDA7679099
         
    IGF1R for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for IGF1R:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death HMECs cel  Increased colony dispersion (i 
     Weaker migration 

         15/22 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Igf1r) (see all 22):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    IGF1R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IGF1R: Igf1rtm2.1Arge Igf1rtm1.2Mhz Igf1rtm1Mhz Igf1rtm1Arge

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGF1R 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGF1R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGF1R 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGF1R 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IGF1R:
    hsa-mir-194 (MIRT005892), hsa-mir-7 (MIRT005364), hsa-mir-145 (MIRT004931), hsa-mir-133b (MIRT004460), hsa-mir-138 (MIRT005691), hsa-mir-122 (MIRT000364)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGF1R
    8/185 QIAGEN miScript miRNA Assays for microRNAs that regulate IGF1R (see all 185):
    hsa-miR-194* hsa-miR-411* hsa-miR-140-5p hsa-miR-631 hsa-miR-376b hsa-miR-605 hsa-miR-3653 hsa-miR-409-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    EMD Millipore RNAi Products for the Analysis of IGF1R Gene knock-down
    OriGene RNAi products in human, mouse, rat for IGF1R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGF1R

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IGF1R
    Sirion Biotech Customized adenovirus for overexpression of IGF1R

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IGF1R (see all 9)
    OriGene ORF clones in mouse, rat for IGF1R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IGF1R (NM_000875)
    Sino Biological Human cDNA Clone for IGF1R
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGF1R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF1R
    Sirion Biotech Customized lentivirus for stable overexpression of IGF1R 
                         Customized lentivirus expression plasmids for stable overexpression of IGF1R 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IGF1R
    Search LifeMap BioReagents cell lines for IGF1R
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF1R


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGF1R About   (see all 61)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Glioma
    Glioma0.51
    Prostate cancer0.39
    Melanoma0.43
    Signaling Pathways in Glioblastoma0.36
    3Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    4Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Actin-Based Motility by Rho Family GTPases0.62
    Apoptotic Pathways in Synovial Fibroblasts0.84
    ERK5 Signaling0.61
    p53 Mediated Apoptosis0.84
    eIF2 Pathway0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/13 EMD Millipore Pathways for IGF1R (see all 13)
        Transcription Androgen Receptor nuclear signaling
    Signal transduction PTEN pathway
    Transcription CREB pathway
    Development Ligand-independent activation of ESR1 and ESR2
    G-protein signaling RhoA regulation pathway

    1 R&D Systems Pathway for IGF1R
        Akt Signaling Pathway

    5/61 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IGF1R (see all 61)
        Nuclear Receptor Activation by Vitamin-A
    RhoA Pathway
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis

    2 Cell Signaling Technology (CST) Pathways for IGF1R
        Tyrosine Kinases / Adaptors
    Glucose / Energy Metabolism

    5 Tocris Bioscience Pathways for IGF1R
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    mTOR Pathway

    5/13 GeneGo (Thomson Reuters) Pathways for IGF1R (see all 13)
        Transcription Androgen Receptor nuclear signaling
    Apoptosis and survival Caspase cascade
    Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction AKT signaling

    5/13 BioSystems Pathways for IGF1R (see all 13)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Apoptosis
    Senescence and Autophagy
    Insulin Signaling


    5        Reactome Pathways for IGF1R
        Signal Transduction
    IGF1R signaling cascade
    IRS-related events triggered by IGF1R
    SHC-related events triggered by IGF1R
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)


    5/15         Kegg Pathways  (Kegg details for IGF1R) (see all 15):
        HIF-1 signaling pathway
    Oocyte meiosis
    Endocytosis
    PI3K-Akt signaling pathway
    Focal adhesion


    IGF1R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGF1R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/174 Interacting proteins for IGF1R (P080691, 2, 3 ENSP000002680354) via UniProtKB, MINT, STRING, and/or I2D (see all 174)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSKP412402, 3, ENSP000002200034MINT-8029130 MINT-8032913 MINT-8032928 MINT-8029145 MINT-8032898 MINT-8029115 I2D: score=5 STRING: ENSP00000220003
    YWHAEP622582, 3, ENSP000002643354MINT-18626 MINT-18625 MINT-18624 MINT-8005112 I2D: score=5 STRING: ENSP00000264335
    IRS2Q9Y4H22, 3, ENSP000003650164MINT-17857 MINT-18053 I2D: score=3 STRING: ENSP00000365016
    IGF1RP080691, 2EBI-475981,EBI-475981 MINT-4981138
    ARHGEF12Q9NZN52, 3, ENSP000003809424MINT-1774956 MINT-1774857 MINT-1774918 MINT-1774802 MINT-1774883 MINT-1774936 MINT-1774976 I2D: score=3 STRING: ENSP00000380942
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006955immune response IMP16886151
    GO:0007165signal transduction TAS3003744
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0007409axonogenesis IEA--

    IGF1R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGF1R for compounds           About GeneDecksing

    EMD Millipore small molecules for IGF1R:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for IGF1R

    Compounds for IGF1R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PicropodophyllotoxinSelective IGF1R inhibitor[477-47-4]
    Demethylasterriquinone B1Selective insulin RTK activator[78860-34-1]
    BMS 536924Dual IR/IGF1R inhibitor[468740-43-4]
    Insulin (human) recombinantEndogenous peptide agonist[11061-68-0]

    2 HMDB Compounds for IGF1R    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    9 DrugBank Compounds for IGF1R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Insulin, porcine-- 9004-14-2target--9582514 7476290 17016423 17139284 9846170
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423
    Insulin Regular -- 11061-68-0target--17139284 17016423
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423
    (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione-- --target--10592235
    3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE-- --target--10592235
    Insulin Glargine-- 160337-95-1targetagonist20392809
    Insulin Lispro-- 133107-64-9target--20392809
    Mecasermin-- 68562-41-4targetagonist19198769

    2 IUPHAR Ligands for IGF1R (Insulin-like growth factor I)    About this table 
    LigandTypeActionAffinityPubmed IDs
    IGF1
    NoneNone--
    IGF2
    NoneNone--

    10/129 Novoseek inferred chemical compound relationships for IGF1R gene (see all 129)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ag 1024 89.1 37 19166817 (2), 15613453 (2), 16752221 (1), 18635919 (1) (see all 21)
    tyrosine 79.5 333 8593783 (5), 18263593 (4), 1322128 (4), 1311242 (3) (see all 99)
    mannose 6-phosphate 72.3 30 7588242 (4), 7957246 (2), 8188767 (2), 1657932 (2) (see all 21)
    phosphatidylinositol 71.4 52 1317864 (5), 1311242 (3), 9524259 (1), 10203689 (1) (see all 37)
    podophyllotoxin 62.5 31 18070930 (5), 20150364 (3), 20200966 (1), 17828296 (1) (see all 10)
    ly294002 60.9 3 12460191 (1), 20200966 (1), 12204896 (1)
    estrogen 60.7 101 10749889 (6), 10967123 (3), 11431145 (2), 17138646 (2) (see all 61)
    ascorbyl stearate 58.9 4 11763418 (2), 12645815 (1)
    thymidine 54.6 15 2164527 (1), 10036618 (1), 11924572 (1), 1483875 (1) (see all 12)
    rapamycin 54.5 43 18630505 (3), 19789339 (3), 20486173 (2), 17001314 (2) (see all 22)

    Search CenterWatch for drugs/clinical trials and news about IGF1R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGF1R gene (2 alternative transcripts): 
    NM_000875.3  NM_152452.1  

    Unigene Cluster for IGF1R:

    Insulin-like growth factor 1 receptor
    Hs.643120  [show with all ESTs]
    Unigene Representative Sequence: AB425196
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268035(uc002bul.3 uc010bon.3 uc010boo.1) ENST00000558762(uc010urq.2)
    ENST00000559925(uc010urr.1) ENST00000558355 ENST00000557938 ENST00000560186
    ENST00000560277 ENST00000557873 ENST00000558898 ENST00000560432 ENST00000558947
    ENST00000559582 ENST00000560144 ENST00000561049 ENST00000560343 ENST00000560972
    ENST00000558751

    miRNA
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    8/185 QIAGEN miScript miRNA Assays for microRNAs that regulate IGF1R (see all 185):
    hsa-miR-194* hsa-miR-411* hsa-miR-140-5p hsa-miR-631 hsa-miR-376b hsa-miR-605 hsa-miR-3653 hsa-miR-409-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    EMD Millipore RNAi Products for the Analysis of IGF1R Gene knock-down
    OriGene RNAi products in human, mouse, rat for IGF1R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGF1R
    Clone
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    OriGene clones in human, mouse for IGF1R (see all 9)
    OriGene ORF clones in mouse, rat for IGF1R
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    GenScript: all cDNA clones in your preferred vector: IGF1R (NM_000875)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF1R
    Sirion Biotech Customized lentivirus for stable overexpression of IGF1R 
                         Customized lentivirus expression plasmids for stable overexpression of IGF1R 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGF1R

    Additional mRNA sequence: 

    AB425196.1 AK310188.1 AY429545.1 BC010607.1 BC078157.1 BC088377.1 BC107089.1 BC111046.1 
    BC113610.1 BC113612.1 BC143721.1 EU826611.1 EU826612.1 U09023.1 X04434.1 

    12 DOTS entries:

    DT.444626  DT.456085  DT.97771501  DT.100026379  DT.100754588  DT.100720157  DT.121017124  DT.121017036 
    DT.121017096  DT.99953925  DT.102837299  DT.95081321 

    24/113 AceView cDNA sequences (see all 113):

    BX093045 CA946988 BE677810 AI369152 BM129719 BM677747 BU581180 AW612405 
    AI369383 AI375882 BX950968 AU141484 AW269425 AI687898 BQ417379 BE328099 
    AW612013 BU948608 CA946716 AI971190 AI658710 BM695198 AI458627 R35104 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for IGF1R (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:              -     -     -     -     -     -                                                     -                                   -                 -   
    SP2:                                                                                                                                                            
    SP3:                                -     -     -                                                                                                               
    SP4:                          -     -     -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b
    SP1:                                                                    -               
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for IGF1R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGF1R expression in normal human tissues (normalized intensities)      IGF1R embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTAAGTTA
    IGF1R Expression
    About this image


    IGF1R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 15 entries
             Endochondral Osteoblasts Rostral Endochondral Facial Bones
             Bone marrow-derived mesenchymal stem cells
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Mature Choroid Plexus Cells Choroid Plexus
             superior temporal gyrus   
     
     Hair (Integumentary System)    fully expand to see all 3 entries
             Fetal Precortex Cells Hair Shaft
     
     Choroid Plexus (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla

    See IGF1R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGF1R

    SOURCE GeneReport for Unigene cluster: Hs.643120

    UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
    Tissue specificity: Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal
    muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues.
    Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including IGF1R (see all 13): 
              Osteogenesis in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Apoptosis in human mouse rat
              Cell Motility in human mouse rat
              Cancer Drug Targets in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF1R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IGF1R gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igf1r1 , 5 insulin-like growth factor I receptor1, 5 89.56(n)1
    96.12(a)1
      7 (37.27 cM)5
    160011  NM_010513.21  NP_034643.21 
     679528595 
    chicken
    (Gallus gallus)
    Aves IGF1R1 insulin-like growth factor 1 receptor 79.26(n)
    84.99(a)
      395889  NM_205032.1  NP_990363.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGF1R6
    Tyrosine-protein kinase receptor
    80(a)
    1 ↔ 1
    GL343383.1(49242-234776)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980222 insulin-like growth factor-1 receptor beta subunit 74.91(n)    AF055980.1 
    zebrafish
    (Danio rerio)
    Actinopterygii igf1ra2 insulin-like growth factor 1a receptor 76.93(n)   245701  AF400275.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sev3
    InR1
    R7 cell fate commitment protein
    tyrosine kinase3
    Insulin-like receptor1
    49(a)
    (best of 5)3
    50.61(n)1
    42.47(a)1
      1 10A43
    425491  NM_001144622.11  NP_001138094.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R151.43
    daf-21
    Tyrosine kinase3
    Protein DAF-21
    38(a)
    (best of 8)3
    44.64(n)1
    34.94(a)1
      III(7291720-7292812)3
    1754101  NM_065249.31  NP_497650.31 


    ENSEMBL Gene Tree for IGF1R (if available)
    TreeFam Gene Tree for IGF1R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGF1R gene
    ROR12  INSR2  ROS12  NTRK22  LTK2  PTK72  DDR12  NTRK32  
    INSRR2  ROR22  DDR22  MUSK2  ALK2  NTRK12  
    18/27 SIMAP similar genes for IGF1R using alignment to 7 protein entries:     IGF1R_HUMAN (see all proteins) (see all similar genes):
    RET    INSRR    INSR    MET    ABL1    DKFZp434L0319
    EPHA2    FES    PTK6    tec    KIT    SLC34A2/ROS1 fusion
    BTK kinase deficient isoform 6    FGFR3    FGFR1    FGR    BTK kinase deficient isoform 2    RYK

    IGF1R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7685 SNPs in IGF1R are shown (see all 7685)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0348924
    Insulin-like growth factor 1 resistance (IGF1RES)4--see VAR_0348922 K N mis40--------
    VAR_0348914
    Insulin-like growth factor 1 resistance (IGF1RES)4--see VAR_0348912 R Q mis40--------
    VAR_0414284
    A lung squamous cell carcinoma sample4--see VAR_0414282 A V mis40--------
    VAR_0348954
    Insulin-like growth factor 1 resistance (IGF1RES)4--see VAR_0348952 R Q mis40--------
    rs339581761,2,4
    C,Fpathogenic181455171(+) GCACCG/AGTACC 2 /Q /R mis111Minor allele frequency- A:0.00NA EU CSAM EA 6263
    VAR_0414244
    ----see VAR_0414242 V L mis40--------
    rs357078921,2
    F--75318883(+) GGCTGC/ACCTCC 1 -- us2k15Minor allele frequency- A:0.03NA EU CSAM EA 380
    rs355540271,2
    C,F--75319052(+) TTCCCC/GCTCCG 1 -- us2k18Minor allele frequency- G:0.36NA EU CSAM EA WA 620
    rs722225661,2
    C--75319146(+) AGCCT-/G/GG  
            
    GGGGG
    1 -- us2k10--------
    rs342263281,2
    C,F--75320385(+) GGCTCC/TGGAGG 2 S syn17Minor allele frequency- T:0.00NA EU CSAM EA 4734

    HapMap Linkage Disequilibrium report for IGF1R (99192200 - 99442200 bp, first 250kb of IGF1R)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for IGF1R:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2750109CNV Deletion23290073
    esv2750108CNV Deletion23290073
    nsv904540CNV Loss21882294
    nsv904541CNV Loss21882294
    nsv526399CNV Loss19592680
    esv27037CNV Loss19812545
    nsv827457CNV Gain20364138
    esv33604CNV Gain17666407
    esv32729CNV Gain17666407


    Human Gene Mutation Database (HGMD): IGF1R

    Locus Specific Mutation Databases (LSDB): IGF1R
    SABiosciences Cancer Mutation PCR Assays
    3 SABiosciences qBiomarker Copy Number PCR Arrays containing IGF1R:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing IGF1R
    DNA2.0 Custom Variant and Variant Library Synthesis for IGF1R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147370   
    OMIM disorders: 270450  
    UniProtKB/Swiss-Prot: IGF1R_HUMAN, P08069
  • Insulin-like growth factor 1 resistance (IGF1RES) [MIM:270450]: A disorder characterized by intrauterine
    growth retardation, poor postnatal growth and increased plasma IGF1 levels. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 20/163 diseases for IGF1R (see all 163):    About MalaCards
    insulin-like growth factor 1 resistance to    ring chromosome 15    donohue syndrome    rabson-mendenhall syndrome
    lymphangioleiomyomatosis    ring chromosomes    acanthosis nigricans    rhabdoid tumor
    insulin resistance    atypical teratoid rhabdoid tumor    gastrinoma    idiopathic short stature
    beckwith-wiedemann syndrome    peripheral primitive neuroectodermal tumor    skeletal muscle regeneration    seckel syndrome
    polycythemia vera    hyperinsulinemic hypoglycemia    keloids    alveolar rhabdomyosarcoma

    8 diseases from the University of Copenhagen DISEASES database for IGF1R:
    Breast cancer     Sarcoma     Lung cancer     Peripheral primitive neuroectodermal tumor
    Carcinoma     Prostate cancer     Rhabdomyosarcoma     Colorectal cancer

    IGF1R for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for IGF1R gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    igf-i resistance 82.9 7 1437400 (1), 8077364 (1), 15476454 (1), 1386373 (1) (see all 7)
    breast cancer 66.9 243 15687676 (7), 17210722 (6), 15619214 (4), 15987464 (3) (see all 99)
    tumors 65.7 415 20486173 (5), 17651787 (5), 11550306 (4), 10446966 (4) (see all 99)
    leprechaunism 63.8 1 9003010 (1)
    cancer 60.2 259 17393577 (4), 17651787 (4), 15956962 (4), 15566314 (4) (see all 99)
    ewings sarcoma 59.2 24 16740780 (4), 1315779 (2), 11896447 (2), 19840522 (1) (see all 13)
    osteosarcoma 52.3 40 19229591 (6), 20486173 (4), 15738602 (2), 10453987 (1) (see all 19)
    prostate cancer 51.6 100 12019176 (6), 17065200 (5), 12581018 (4), 15499378 (4) (see all 47)
    rhabdomyosarcoma 48 11 8083365 (3), 18829562 (1), 11807989 (1), 9537584 (1) (see all 5)
    growth retardation 46.7 22 20103656 (2), 16151622 (1), 15476454 (1), 15384084 (1) (see all 16)

    Genetic Association Database (GAD): IGF1R
    Human Genome Epidemiology (HuGE) Navigator: IGF1R (84 documents)
    Tumor Gene Database (TGDB): IGF1R

    Export disorders for IGF1R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGF1R gene, integrated from 9 sources (see all 1938):
    (articles sorted by number of sources associating them with IGF1R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. (PubMed id 14657428)1, 2, 4, 9 Abuzzahab M.J.... Chernausek S.D. (2003)
    2. Insulin-like growth factor I receptor gene structure. (PubMed id 1316909)1, 2, 3 Abbot A.M.... Smith R.J. (1992)
    3. Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. (PubMed id 12019176)1, 2, 9 Hellawell G.O....Macaulay V.M. (2002)
    4. Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. (PubMed id 12821780)1, 2, 9 Girnita L....Larsson O. (2003)
    5. Insulin-like growth factor receptor 1 (IGF1R) gene co py number is associated with survival in operable non-small-cell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression , and mRNA expression. (PubMed id 20351332)1, 4, 9 Dziadziuszko R....Hirsch F.R. (2010)
    6. {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. (PubMed id 15878855)1, 2, 9 Girnita L.... Larsson O. (2005)
    7. Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study. (PubMed id 17063263)1, 4, 9 Deming S.L....Zheng W. (2007)
    8. Role of genetic variation in insulin-like growth fact or 1 receptor on insulin resistance and arterial hypertension. (PubMed id 20179633)1, 4, 9 Sookoian S....Pirola C.J. (2010)
    9. A polymorphic variant of the insulin-like growth fact or type I receptor gene modifies risk of obesity for esophageal adenocarcinoma. (PubMed id 19679045)1, 4, 9 MacDonald K....Casson A.G. (2009)
    10. A polymorphic variant of the insulin-like growth fact or 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the 'Treviso Lon geva (TRELONG)' study. (PubMed id 19460140)1, 4, 9 Albani D....Forloni G. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3480 HGNC: 5465 AceView: IGF1R Ensembl:ENSG00000140443 euGenes: HUgn3480
    ECgene: IGF1R Kegg: 3480 H-InvDB: IGF1R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGF1R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGF1R Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igf1r/
    Wikipedia http://en.wikipedia.org/wiki/IGF-1_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGF1R gene:
    Search GeneIP for patents involving IGF1R

    GeneCards and IP:
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