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Aliases for IGF1 Gene

Aliases for IGF1 Gene

  • Insulin Like Growth Factor 1 2 3 5
  • Insulin-Like Growth Factor 1 (Somatomedin C) 2 3
  • Mechano Growth Factor 3 4
  • Somatomedin-C 3 4
  • IGF-I 3 4
  • MGF 3 4
  • Insulin-Like Growth Factor IB 3
  • Insulin-Like Growth Factor I 3
  • Somatomedin C 2
  • IBP1 4
  • IGFI 3

External Ids for IGF1 Gene

Previous GeneCards Identifiers for IGF1 Gene

  • GC12M101888
  • GC12M102748
  • GC12M101292
  • GC12M099849

Summaries for IGF1 Gene

Entrez Gene Summary for IGF1 Gene

  • The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

GeneCards Summary for IGF1 Gene

IGF1 (Insulin Like Growth Factor 1) is a Protein Coding gene. Diseases associated with IGF1 include Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency and Insulin-Like Growth Factor I. Among its related pathways are GPCR Pathway and Transcription_Role of VDR in regulation of genes involved in osteoporosis. GO annotations related to this gene include growth factor activity and integrin binding. An important paralog of this gene is IGF2.

UniProtKB/Swiss-Prot for IGF1 Gene

  • The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309).

Tocris Summary for IGF1 Gene

  • Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IR homodimers are activated by insulin.

Gene Wiki entry for IGF1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF1 Gene

Genomics for IGF1 Gene

Regulatory Elements for IGF1 Gene

Enhancers for IGF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G101929 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +546.6 546618 10.5 HDGF PKNOX1 ATF1 WRNIP1 FEZF1 GLIS2 GATA2 ZNF143 ZNF207 FOS GNPTAB WASHC3 IGF1 RNA5SP369 RNU6-101P SYCP3 DRAM1 CHPT1 RPL9P24 GC12P101929
GH12G101924 1.3 Ensembl ENCODE dbSUPER 9.8 +555.3 555330 4.3 CBX3 CHAMP1 FOS EGR2 NFYA CEBPB USF2 NFYC REST POLR2H RNA5SP369 GNPTAB IGF1 SYCP3 DRAM1 CHPT1 GC12P101926 GC12P101929
GH12G102438 1.1 ENCODE dbSUPER 11.3 +42.5 42514 2.5 HDAC1 ATF1 ZNF766 ZBTB11 ZNF426 USF2 REST MIER2 ZNF781 ZNF518A WASHC3 IGF1 NUP37 GC12M102404
GH12G102454 1 ENCODE dbSUPER 11.9 +26.5 26456 1.3 CTCF TAL1 MAX CEBPG ZNF644 RAD21 YY1 IRF9 HLF CEBPB IGF1 GC12M102404
GH12G102429 1.1 ENCODE dbSUPER 10.8 +51.9 51896 0.3 PKNOX1 TBL1XR1 CREB3L1 NFRKB ZNF766 CEBPB NCOA1 REST NR2F2 ZNF592 IGF1 GC12M102404
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGF1 Gene

Chromosome:
12
Start:
102,395,867 bp from pter
End:
102,481,786 bp from pter
Size:
85,920 bases
Orientation:
Minus strand

Genomic View for IGF1 Gene

Genes around IGF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF1 Gene

Proteins for IGF1 Gene

  • Protein details for IGF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05019-IGF1_HUMAN
    Recommended name:
    Insulin-like growth factor I
    Protein Accession:
    P05019
    Secondary Accessions:
    • B2RWM7
    • E9PD02
    • P01343
    • Q14620

    Protein attributes for IGF1 Gene

    Size:
    195 amino acids
    Molecular mass:
    21841 Da
    Quaternary structure:
    • Forms a ternary complex with IGFR1 and ITGAV:ITGB3 (PubMed:19578119). Forms a ternary complex with IGFR1 and ITGA6:ITGB4 (PubMed:22351760, PubMed:23696648).
    SequenceCaution:
    • Sequence=CAA27250.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGF1 Gene

    Alternative splice isoforms for IGF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGF1 Gene

Post-translational modifications for IGF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Assay Products

  • Enzo Life Sciences assays for IGF1

No data available for DME Specific Peptides for IGF1 Gene

Domains & Families for IGF1 Gene

Gene Families for IGF1 Gene

Graphical View of Domain Structure for InterPro Entry

P05019

UniProtKB/Swiss-Prot:

IGF1_HUMAN :
  • Belongs to the insulin family.
Family:
  • Belongs to the insulin family.
genes like me logo Genes that share domains with IGF1: view

Function for IGF1 Gene

Molecular function for IGF1 Gene

GENATLAS Biochemistry:
insulin-like growth factor 1,expressed in liver,regulator of somatic growth and cellular proliferation,inducer of the phosphatidylinositol 3-kinase survival pathway through activation of AKT1,AKT2,inhibited by TNF in its neuroprotective role,also inducer of calcineurin mediated signaling and activation of GATA2,associated with intrauterine growth retardation and severe short stature in a patient carrying a homozygous deletion of IGF1
UniProtKB/Swiss-Prot Function:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309).

LifeMap Function Summary for IGF1 Gene

It affects the following cells:
IGF1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005158 insulin receptor binding IPI 8452530
GO:0005159 insulin-like growth factor receptor binding IPI 8452530
GO:0005178 integrin binding IDA 19578119
GO:0005179 hormone activity TAS,IDA 7188854
GO:0005515 protein binding IPI 8452530
genes like me logo Genes that share ontologies with IGF1: view
genes like me logo Genes that share phenotypes with IGF1: view

Human Phenotype Ontology for IGF1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IGF1 Gene

MGI Knock Outs for IGF1:

Animal Model Products

miRNA for IGF1 Gene

miRTarBase miRNAs that target IGF1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IGF1 Gene

Localization for IGF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGF1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for IGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 7188854
GO:0005886 plasma membrane TAS --
GO:0016942 insulin-like growth factor binding protein complex IC 10766744
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with IGF1: view

Pathways & Interactions for IGF1 Gene

genes like me logo Genes that share pathways with IGF1: view

SIGNOR curated interactions for IGF1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IMP 22351760
GO:0001501 skeletal system development TAS 10448861
GO:0001775 cell activation IDA 22797923
GO:0002576 platelet degranulation TAS --
GO:0006260 DNA replication TAS 10766744
genes like me logo Genes that share ontologies with IGF1: view

Drugs & Compounds for IGF1 Gene

(98) Drugs for IGF1 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N,N-bis(3-(D-gluconamido)propyl)deoxycholamide Experimental Pharma Target 0
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate Experimental Pharma Target 0
Anesthetics Pharma 9596
Anesthetics, Local Pharma 3492
insulin Pharma 4646

(47) Additional Compounds for IGF1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6bK
1774353-12-6
BMS 536924
468740-43-4
Insulin (human) recombinant
11061-68-0
Picropodophyllotoxin
477-47-4

(5) Tocris Compounds for IGF1 Gene

Compound Action Cas Number
6bK Insulin degrading enzyme (IDE) inhibitor 1774353-12-6
BMS 536924 Dual IR/IGF1R inhibitor 468740-43-4
Insulin (human) recombinant Endogenous peptide agonist 11061-68-0
Mitoglitazone Insulin sensitizer; exhibits low binding affinity at PPARgamma 146062-49-9
Picropodophyllotoxin Selective IGF1R inhibitor 477-47-4

(3) ApexBio Compounds for IGF1 Gene

Compound Action Cas Number
Demethylasterriquinone B1 78860-34-1
HNGF6A 1093111-54-6
Insulin (human) recombinant expressed in yeast peptide hormone 11061-68-0
genes like me logo Genes that share compounds with IGF1: view

Drug Products

Transcripts for IGF1 Gene

Unigene Clusters for IGF1 Gene

Insulin-like growth factor 1 (somatomedin C):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGF1 Gene

No ASD Table

Relevant External Links for IGF1 Gene

GeneLoc Exon Structure for
IGF1
ECgene alternative splicing isoforms for
IGF1

Expression for IGF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGF1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for IGF1 Gene

This gene is overexpressed in Serum (25.5), Plasma (19.7), Skin (16.2), and Synovial fluid (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGF1 Gene



Protein tissue co-expression partners for IGF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGF1 Gene:

IGF1

SOURCE GeneReport for Unigene cluster for IGF1 Gene:

Hs.160562

Evidence on tissue expression from TISSUES for IGF1 Gene

  • Liver(4.8)
  • Nervous system(4.7)
  • Muscle(3.7)
  • Blood(3.4)
  • Heart(3.3)
  • Bone(3.2)
  • Intestine(3.2)
  • Thyroid gland(3.1)
  • Kidney(2.9)
  • Adrenal gland(2.7)
  • Skin(2.6)
  • Lung(2.5)
  • Bone marrow(2.3)
  • Pancreas(2.3)
  • Eye(2.2)
  • Spleen(2.2)
  • Gall bladder(2.1)
  • Stomach(2.1)
  • Urine(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IGF1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • chin
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with IGF1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IGF1 Gene

Orthologs for IGF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGF1 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia IGF1 34 35
  • 93.68 (n)
cow
(Bos Taurus)
Mammalia IGF1 34
  • 93.46 (n)
IGF-I 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igf1 34 16 35
  • 88.67 (n)
rat
(Rattus norvegicus)
Mammalia Igf1 34
  • 88.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IGF1 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGF1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGF1 34 35
  • 80.61 (n)
lizard
(Anolis carolinensis)
Reptilia IGF1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486334 34
  • 77.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia igf1-A 34
zebrafish
(Danio rerio)
Actinopterygii igf1 34 35
  • 67.36 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11904 34
Species where no ortholog for IGF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGF1 Gene

ENSEMBL:
Gene Tree for IGF1 (if available)
TreeFam:
Gene Tree for IGF1 (if available)

Paralogs for IGF1 Gene

Paralogs for IGF1 Gene

(3) SIMAP similar genes for IGF1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IGF1: view

Variants for IGF1 Gene

Sequence variations from dbSNP and Humsavar for IGF1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs121912430 Pathogenic 102,419,637(-) GCATC(A/G)TGGAT intron-variant, reference, missense
rs587779350 Pathogenic 102,419,619(-) GCTTC(C/T)GGAGC intron-variant, reference, missense
rs147578960 Likely benign 102,401,753(+) CTCTT(-/TT)GAGTT intron-variant, utr-variant-3-prime
rs17881987 Likely benign 102,398,023(-) TCTTC(-/T)TTTTT intron-variant, utr-variant-3-prime
rs3032449 Likely benign 102,402,246(+) TATAT(A/T)TTTTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IGF1 Gene

Variant ID Type Subtype PubMed ID
esv2663083 CNV deletion 23128226
esv3309220 CNV mobile element insertion 20981092
esv3445771 CNV insertion 20981092
esv3630590 CNV loss 21293372
esv3630591 CNV loss 21293372
nsv560034 CNV loss 21841781
nsv560035 CNV loss 21841781
nsv819617 CNV gain 19587683
nsv832498 CNV gain 17160897
nsv832499 CNV gain 17160897

Variation tolerance for IGF1 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGF1 Gene

Human Gene Mutation Database (HGMD)
IGF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGF1 Gene

Disorders for IGF1 Gene

MalaCards: The human disease database

(133) MalaCards diseases for IGF1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
growth retardation with deafness and mental retardation due to igf1 deficiency
  • insulin-like growth factor i deficiency
insulin-like growth factor i
  • insulin-like growth factor i deficiency
pituitary gland disease
  • pituitary disease
diffuse idiopathic skeletal hyperostosis
  • ankylosing vertebral hyperostosis
osteochondrosis
  • juvenile osteochondrosis of tibial tubercle
- elite association - COSMIC cancer census association via MalaCards
Search IGF1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IGF1_HUMAN
  • Insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]: Autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. {ECO:0000269 PubMed:8857020}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IGF1

Genetic Association Database (GAD)
IGF1
Human Genome Epidemiology (HuGE) Navigator
IGF1
Tumor Gene Database (TGDB):
IGF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGF1
genes like me logo Genes that share disorders with IGF1: view

No data available for Genatlas for IGF1 Gene

Publications for IGF1 Gene

  1. Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. (PMID: 18059035) Slattery M.L. … Potter J.D. (Int. J. Cancer 2008) 3 22 46 64
  2. Genetic risk factors of bronchopulmonary dysplasia. (PMID: 18614962) Kwinta P. … Pietrzyk J.J. (Pediatr. Res. 2008) 3 22 46 64
  3. IGF-II gene region polymorphisms related to exertional muscle damage. (PMID: 17289909) Devaney J.M. … Clarkson P.M. (J. Appl. Physiol. 2007) 3 22 46 64
  4. Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels. (PMID: 17911177) Johansson M. … Kaaks R. (J. Clin. Endocrinol. Metab. 2007) 3 22 46 64
  5. Insulin-like growth factor-1 genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating insulin-like growth factor-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families. (PMID: 17010055) JernstrAPm H. … Olsson H. (Int. J. Gynecol. Cancer 2006) 3 22 46 64

Products for IGF1 Gene

Sources for IGF1 Gene

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