Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGF1 Gene

protein-coding   GIFtS: 72
GCID: GC12M102748

insulin-like growth factor 1 (somatomedin C)
 Explore 442 diseases affiliated with
IGF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGF1    

Aliases
for IGF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Insulin-Like Growth Factor 1 (Somatomedin C)1 2     Insulin-Like Growth Factor 12
IGF1A1 2     Insulin-Like Growth Factor I2
Mechano Growth Factor2 3     Insulin-Like Growth Factor IA2
IGF-I2 3     Insulin-Like Growth Factor IB2
MGF2 3     Somatomedin-C3
IGF-IA2     IBP13
IGF-IB2     Somatomedin-C3
IGFI2     

External Ids:    HGNC: 54641   Entrez Gene: 34792   Ensembl: ENSG000000174277   OMIM: 1474405   UniProtKB: P050193   

Export aliases for IGF1 gene to outside databases

Previous GC identifers: GC12M101888 GC12M101292 GC12M099849


Summaries
for IGF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IGF1:
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of
proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a
specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several
transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: IGF1_HUMAN, P05019
Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin
but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG)
transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS)
cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but
also with regard to enhancing glucose uptake

summary for IGF1:
Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each
of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular
tyrosine kinase activity. IR homodimers are activated by insulin and in adults, mediate an increase in
glucose uptake through upregulation of Glut4 expression. Two isoforms of the IR exist; fetal IR-A and adult
IR-B. IGF1R homodimers are activated by IGF-I and IGF-II and mediate pre- and postnatal growth. IGF2R
sequesters IGF-II and acts to regulate its levels. IR-IGF1R heterodimers exist and, like IGF1R homodimers,
are activated by IGF-I and IGF-II. IRs and IGFRs mediate their intracellular actions through the PI 3-K and
RAS/RAF/MAPK signaling pathways and downstream effectors include mTOR, p70 S6 kinase, ERK and JNK. Many
tumors have altered expression of IGF1R and its ligands and this constitutes an early, possible initiating,
event in tumorigenesis. Decreases in IR signaling causing insulin resistance is a major component in the
development of type 2 diabetes and congenital mutations in the IR can cause the fatal Donohue syndrome.

Gene Wiki entry for IGF1 (Insulin-like growth factor 1)


Genomic Views
for IGF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGF1 gene promoter:
         STAT5B   SRF   C/EBPbeta   SRF (504 AA)   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.2

IGF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M102748:  view genomic region     (about GC identifiers)

Start:
 102,789,645 bp from pter      End:
 102,874,423 bp from pter
Size:
 84,779 bases      Orientation:
 minus strand

Proteins
for IGF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IGF1_HUMAN, P05019 (See protein sequence)
Recommended Name: Insulin-like growth factor I precursor  
Size: 195 amino acids; 21841 Da
Subcellular location: Secreted
Sequence caution: Sequence=CAA27250.1; Type=Erroneous gene model prediction;
6/18 PDB 3D structures from and Proteopedia for IGF1 (see all 18):
1B9G (3D)        1BQT (3D)        1GF1 (3D)        1GZR (3D)        1GZY (3D)        1GZZ (3D)    
Secondary accessions: B2RWM7 P01343 Q14620
Alternative splicing: 3 isoforms:  P05019-1   P05019-2   P05019-3   (Expressed in liver)

Explore the universe of human proteins at neXtProt for IGF1: NX_P05019

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P05019

    • IGF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_000609.1  NP_001104753.1  NP_001104754.1  NP_001104755.1  

    ENSEMBL proteins: 
     ENSP00000337612   ENSP00000376637   ENSP00000416811   ENSP00000376638   ENSP00000302665  
     ENSP00000394999  
    Reactome Protein details: P05019
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant IGF1 Protein
    R&D Systems Recombinant & Natural Proteins for IGF1 (IGF-I)
    Enzo Life Sciences proteins for IGF1
    OriGene Purified Protein: IGF1
    OriGene Protein Over-expression Lysate (see all 3): IGF1
    OriGene Custom Protein Services for IGF1 
    GenScript Purified and Recombinant Proteins for IGF1
    Novus Biologicals IGF1 Proteins
    Novus Biologicals IGF1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for IGF1
    Uscn Proteins for IGF1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA7188854
    GO:0016942insulin-like growth factor binding protein complex IC10766744
    GO:0031093platelet alpha granule lumen TAS--


    IGF1 for ontologies           About GeneDecksing



    IGF1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IGF1
    R&D Systems Antibodies for IGF1 (IGF-I)
    OriGene Antibodies (see all 2): IGF1
    OriGene Custom Antibody Services for IGF1 
    GenScript Custom Superior Antibodies Services for IGF1
    Novus Biologicals IGF1 Antibodies
    Abcam antibodies for IGF1 
    Uscn Antibodies for IGF1
    ThermoFisher Antibody for IGF1

    Assay Products for IGF1: 
    EMD Millipore Kits and Assays for the Analysis of IGF1
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Flow Cytometry Kits for IGF1 (IGF-I)         (see all)
    GenScript Custom Assay Services for IGF1
    Enzo Life Sciences assays for IGF1
    Uscn ELISAs and CLIAs for IGF1

    Protein Domains /
    Families
    for IGF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGF1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016179 Insulin-like
     IPR022350 Insulin-like_growth_factor
     IPR022352 Insulin_family
     IPR022353 Insulin_CS
     IPR022341 IGF-I

    Graphical View of Domain Structure for InterPro Entry P05019

    ProtoNet protein and cluster: P05019

    1 Blocks protein family: IPB004825 Insulin/IGF/relaxin

    UniProtKB/Swiss-Prot: IGF1_HUMAN, P05019
    Similarity: Belongs to the insulin family


    Function
    for IGF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IGF1_HUMAN, P05019
    Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin
    but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG)
    transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS)
    cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but
    also with regard to enhancing glucose uptake

         Genatlas biochemistry entry for IGF1:
    insulin-like growth factor 1,expressed in liver,regulator of somatic growth and cellular proliferation,inducer of the
    phosphatidylinositol 3-kinase survival pathway through activation of AKT1,AKT2,inhibited by TNF in its neuroprotective
    role,also inducer of calcineurin mediated signaling and activation of GATA2,associated with intrauterine growth
    retardation and severe short stature in a patient carrying a homozygous deletion of IGF1

         Summary:  
    During embryonic development, IGF1 as signaling molecule is secreted from the following cells: Hepatocytes in Liver Lobule, Prechondrocytes in Sacral Vertebrae (see all 12).

    It affects the following cells: Endochondral Preosteoblasts in Rostral Endochondral Facial Bones, Endochondral Preosteoblasts in Caudal Endochondral Bones (see all 14).

    IGF1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Motor neuron-like cells, TGF?3- and IGF1-induced embryoid bodies (see all 12).

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 4): IGF1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGF1
    8/170 QIAGEN miScript miRNA Assays for microRNAs that regulate IGF1 (see all 170):
    hsa-miR-361-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-519a hsa-miR-1243 hsa-miR-508-5p hsa-miR-130b hsa-miR-374b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGF1 (see all 7)
    OriGene shRNA RFP: IGF1
    OriGene siRNA: IGF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGF1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IGF1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGF1 (see all 13)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGF1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): IGF1 (NM_001111283)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IGF1
    Search LifeMap BioReagents cell lines for IGF1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF1

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005158insulin receptor binding IPI8452530
    GO:0005159insulin-like growth factor receptor binding IPI8452530
    GO:0005178integrin binding IDA19578119
    GO:0005179hormone activity IDA7188854
    GO:0005515protein binding IPI10766744


    IGF1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IGF1:
     Decreased viability with pacli  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-outs for IGF1: Igf1tm1.1Nros Igf1tm1Arge Igf1tm2.1Nros Igf1tm2Ts Igf1tm1.1Dlr Igf1tm1Ts
         15/20 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Igf1) (see all 20):
     adipose tissue  cardiovascular system  cellular  endocrine/exocrine gland  growth/size 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    IGF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IGF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/51 super-pathways (see all 51) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JAK-STAT Pathway0.57
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/10 EMD Millipore Pathways for IGF1 (see all 10)
        Transcription Androgen Receptor nuclear signaling
    Signal transduction PTEN pathway
    Development Ligand-independent activation of ESR1 and ESR2
    G-protein signaling RhoA regulation pathway
    Development IGF-RI signaling

    5/63 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IGF1 (see all 63)
        Nuclear Receptor Activation by Vitamin-A
    RhoA Pathway
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis

    5/10 GeneGo (Thomson Reuters) Pathways for IGF1 (see all 10)
        Transcription Androgen Receptor nuclear signaling
    Apoptosis and survival Caspase cascade
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    Signal transduction PTEN pathway

    5/9 BioSystems Pathways for IGF1 (see all 9) 
        Apoptosis
    Senescence and Autophagy
    Adipogenesis
    Focal Adhesion
    MicroRNAs in cardiomyocyte hypertrophy

    5/11        Reactome Pathways for IGF1 (see all 11)
        Hemostasis
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    IGF1R signaling cascade
    Response to elevated platelet cytosolic Ca2+
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)


    5/13         Kegg Pathways  (Kegg details for IGF1) (see all 13):
        Oocyte meiosis
    p53 signaling pathway
    mTOR signaling pathway
    Focal adhesion
    Long-term depression


    IGF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/80 Interacting proteins for IGF1 (P050192, 3 ENSP000003026654) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGFBP4P226923, ENSP000002695934I2D: score=4 STRING: ENSP00000269593
    IGFBP5P245933, ENSP000002338134I2D: score=4 STRING: ENSP00000233813
    IGFBP7Q162703, ENSP000002956664I2D: score=3 STRING: ENSP00000295666
    IGFBP1P088333, ENSP000002755254I2D: score=2 STRING: ENSP00000275525
    NOVP487453, ENSP000002595264I2D: score=2 STRING: ENSP00000259526
    About this table

    Gene Ontology (GO): 5/77 biological process terms (GO ID links to tree view) (see all 77):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS10448861
    GO:0001932regulation of protein phosphorylation ----
    GO:0001974blood vessel remodeling IEA--
    GO:0002576platelet degranulation TAS--
    GO:0006260DNA replication TAS10766744


    IGF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for IGF1

    Compounds for IGF1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Demethylasterriquinone B1Selective insulin RTK activator[78860-34-1]
    PQ 401IGF1R inhibitor[196868-63-0]

    2 DrugBank Compounds for IGF1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Deoxy-Bigchap-- --target--17139284 17016423 10592235
    N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate-- --target--10592235

    10/128 Novoseek chemical compound relationships for IGF1 gene (see all 128)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pegvisomant 89 252 17077131 (7), 18498055 (5), 17289896 (5), 20009494 (5) (see all 99)
    octreotide 85.1 486 7535670 (7), 1547711 (7), 19141605 (6), 10468985 (5) (see all 99)
    lanreotide 84 113 10090136 (5), 8921789 (5), 10468985 (3), 10822218 (3) (see all 60)
    testosterone 80 1491 7486812 (7), 15240605 (7), 15978972 (7), 15713723 (6) (see all 99)
    glucose 79.3 1963 8297333 (8), 9651378 (7), 7510305 (6), 12186455 (6) (see all 99)
    estradiol 77.6 695 9626134 (8), 17618061 (6), 19085695 (6), 18498055 (5) (see all 99)
    dehydroepiandrosterone sulfate 74.8 382 17381481 (9), 9100552 (7), 8401752 (7), 10487697 (6) (see all 99)
    phosphatidylinositol 70.9 247 9886492 (5), 1311242 (5), 10707862 (4), 10436165 (3) (see all 99)
    c-peptide 70.1 230 12794762 (4), 7510305 (4), 14770423 (4), 17679371 (4) (see all 99)
    ly294002 69.3 102 17164836 (2), 11145583 (2), 17093064 (2), 10412024 (2) (see all 81)

    Search CenterWatch for drugs/clinical trials and news about IGF1 

    Transcripts
    for IGF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IGF1 gene (4 alternative transcripts): 
    NM_000618.3  NM_001111283.1  NM_001111284.1  NM_001111285.1  

    Unigene Cluster for IGF1:

    Insulin-like growth factor 1 (somatomedin C)
    Hs.160562  [show with all ESTs]
    Unigene Representative Sequence: JX088243
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337514 ENST00000481539 ENST00000392904 ENST00000424202 ENST00000392905
    ENST00000307046(uc001tjp.4) ENST00000456098(uc001tjn.2 uc001tjm.2 uc001tjo.2)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): IGF1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGF1
    8/170 QIAGEN miScript miRNA Assays for microRNAs that regulate IGF1 (see all 170):
    hsa-miR-361-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-519a hsa-miR-1243 hsa-miR-508-5p hsa-miR-130b hsa-miR-374b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGF1 (see all 7)
    OriGene shRNA RFP: IGF1
    OriGene siRNA: IGF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGF1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGF1 (see all 13)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGF1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): IGF1 (NM_001111283)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGF1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGF1
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGF1

    Additional cDNA sequence: 

    AB209184.1 AK312231.1 BC148266.1 BC152321.1 CR541861.1 JX088243.1 M11568.1 M27544.1 
    M29644.1 M37484.1 U40870.1 X00173.1 X56773.1 X56774.1 X57025.1 

    12 DOTS entries:

    DT.454558  DT.92461093  DT.100680034  DT.75105093  DT.92046813  DT.92070424  DT.92070425  DT.95275111 
    DT.100659724  DT.95149146  DT.40304132  DT.95184323 

    24/161 AceView cDNA sequences (see all 161):

    AL709516 AW204378 AI248089 AI457887 H88012 AU118321 X56774 U40870 
    BQ773809 CR541861 BQ787248 AI678264 AA703492 BF222309 M37484 BX281850 
    X56773 CA445905 BQ786970 BE044197 AL708718 AW517507 BQ006168 BF438381 

    GeneLoc Exon Structure


    Expression
    for IGF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IGF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/39 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 39) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod Epiphyseal EndPrechondrocytesBone, Cartilage
    BoneAutopod PeriosteumEndochondral OsteoblastsBone
    BoneCaudal Endochondral BonesEndochondral OsteoblastsBone
    BoneCervical VertebraeEndochondral OsteoblastsBone
    BoneCervical VertebraePrechondrocytesBone, Cartilage
    BoneEndochondral Facial BonesEndochondral OsteoblastsBone
    BoneLumbar VertebraeEndochondral OsteoblastsBone
    BoneLumbar VertebraePrechondrocytesBone, Cartilage
    BoneRostral Endochondral Facial BonesEndochondral OsteoblastsBone
    BoneSacral VertebraeEndochondral OsteoblastsBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Mesenchymal Precursor Cells (STRO-3 selected) (Adult Stem / Progenitor Cell)Bone
    Nkx2-1 GFP+ cells (Efficient derivation...)

    See IGF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGF1

    SOURCE GeneReport for Unigene cluster: Hs.160562
        SABiosciences Expression via Pathway-Focused PCR Arrays including IGF1 (see all 27): 
              TGFB/BMP Signaling Pathway in human mouse rat
              Wound Healing in human mouse rat
              Autophagy in human mouse rat
              Prostate Cancer in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGF1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGF1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGF1
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGF1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF1

    Orthologs
    for IGF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IGF1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Igf11 , 5 insulin-like growth factor 11, 5 85.75(n)1
    89.86(a)1    		   10 (43.70 cM)5
    160001  NM_010512.41  NP_034642.21 
     878582655 
    chicken
    (Gallus gallus)    		 Aves IGF11 insulin-like growth factor 1 (somatomedin C) 80.61(n)
    84.31(a)    		   418090  NM_001004384.2  NP_001004384.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IGF16
    		 --
    		 69(a)
    		 1 ↔ 1
    		 5(17604279-17673944)
    African clawed frog
    (Xenopus laevis)    		 Amphibia igf1-A2 insulin-like growth factor 1 (somatomedin C) 82.94(n)    M29857.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii igf12 insulin-like growth factor 1 77.48(n)   114433  AF268051.1 


    ENSEMBL Gene Tree for IGF1 (if available)
    TreeFam Gene Tree for IGF1 (if available) 

    Paralogs
    for IGF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGF1 gene
    IGF22  
    3 SIMAP similar genes for IGF1 using alignment to 7 protein entries:     IGF1_HUMAN (see all proteins):
    IGF-I    IGF2    INS

    IGF1 for paralogs           About GeneDecksing



    Genomic Variants
    for IGF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1391 NCBI SNPs in IGF1 are shown (see all 1391)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs57427191,2
    		H--99848534(-) TTCACA/GACAGC 3 -- ds50015Minor allele frequency- G:0.00NS EA 590
    rs57427181,2
    		H--99848575(-) TCGTTC/TCAATT 3 -- ds50015Minor allele frequency- T:0.00NS EA 596
    rs57427171,2
    		C,H,--99848707(-) AAATAT/CTCTAT 3 -- ds50015Minor allele frequency- C:0.00NS EA 600
    rs74877281,2
    		H--99848925(+) TTTTTC/TTGGGT 3 -- ds50014Minor allele frequency- T:0.00NS EA 394
    rs57427161,2
    		C,F,H,--99848997(-) TCATTC/TCTTAA 3 -- ds50015Minor allele frequency- T:0.00NS EA 594
    rs37301891,2
    		C,H--99849146(-) CATTAT/GCTTAC 3 -- ut319Minor allele frequency- G:0.00MN NS EA 822
    rs57427151,2
    		C--99849161(-) TGTAAC/ATAATT 3 -- ut316Minor allele frequency- A:0.00NS MN 586
    rs62221,2
    		C,F,H,--99849284(-) CCATTC/TGTTAC 3 -- ut31 ese325Minor allele frequency- T:0.01MN NS EA NA 2738
    rs62151,2
    		C,F,H,--99849357(-) AAGTGT/CGATAA 3 -- ut3116Minor allele frequency- C:0.02MN EA NS NA WA 1744
    rs57427131,2
    		F,H--99849496(-) TATCAC/TGCAGC 3 -- ut31 ese35Minor allele frequency- T:0.01NS EA 596

    HapMap Linkage Disequilibrium report for IGF1 (102789645 - 102874423 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IGF1
         1 Indel: 58548
    Human Gene Mutation Database (HGMD): IGF1

    Locus Specific Mutation Databases (LSDB): IGF1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGF1
    DNA2.0 Custom Variant and Variant Library Synthesis for IGF1

    Disorders / Diseases
    for IGF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGF1 for disorders           About GeneDecksing

    OMIM gene information: 147440   
    OMIM disorders: 608747  
    UniProtKB/Swiss-Prot: IGF1_HUMAN, P05019
  • Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1
    • deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental
    retardation

    20/442 diseases for IGF1 (see all 442):    About MalaCards
    insulin-like growth factor i deficiency    ossification of posterior longitudinal ligament of spine    donohue syndrome    rabson-mendenhall syndrome
    protein-energy malnutrition    acid-labile subunit    insulin resistance    isolated growth hormone deficiency, type ia
    isolated growth hormone deficiency    growth hormone deficiency    hallermann-streiff syndrome    spondyloepiphyseal dysplasia tarda
    growth hormone secreting pituitary adenoma    spondyloepiphyseal dysplasia tarda with progressive arthropathy    monoclonal gammopathy of undetermined significance    erdheim-chester disease
    estrogen-receptor negative breast cancer    diffuse idiopathic skeletal hyperostosis    pallister-hall syndrome    prader-willi syndrome

    20/38 diseases from the University of Copenhagen DISEASES database for IGF1 (see all 38):
    Acromegaly     Diabetes mellitus     Hypopituitarism     Osteoporosis
    Breast cancer     Pituitary adenoma     Hyperinsulinism     Hypoglycemia
    Turner syndrome     Adenoma     Hypogonadism     Hyperglycemia
    Prostate cancer     Polycystic ovary syndrome     Kidney failure     Hypothyroidism
    Hypertension     Myopathy     Autosomal recessive disease     Retinopathy of prematurity

    10/92 Novoseek disease relationships for IGF1 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acromegaly 95.5 943 17575366 (7), 17047383 (6), 7586626 (5), 17431794 (5) (see all 99)
    laron syndrome 89.9 231 14510912 (4), 19117781 (3), 1281024 (3), 10392360 (3) (see all 99)
    growth hormone deficiency 89.6 172 10435854 (6), 8279222 (4), 7904496 (4), 8657365 (4) (see all 96)
    short stature 86.1 289 11155089 (4), 18165284 (4), 10848878 (3), 16820702 (3) (see all 99)
    growth failure 82 113 1919980 (3), 2155253 (2), 7794630 (2), 10359158 (2) (see all 68)
    igf-i resistance 80.5 74 15476454 (3), 8809343 (3), 19046909 (2), 8964861 (2) (see all 35)
    hypopituitarism 80.1 55 17121519 (2), 19226273 (2), 19020378 (2), 1283982 (2) (see all 37)
    pituitary adenoma 77.1 46 19472104 (3), 7691862 (2), 14710344 (2), 16926522 (2) (see all 31)
    insulin resistance 75.5 327 17953765 (5), 9663927 (5), 19902049 (4), 18335323 (3) (see all 99)
    growth retardation 74.8 144 11207641 (4), 9795360 (3), 9364353 (3), 2394775 (2) (see all 98)

    Genetic Association Database (GAD): IGF1
    Human Genome Epidemiology (HuGE) Navigator: IGF1 (289 documents)
    Tumor Gene Database (TGDB): IGF1

    Export disorders for IGF1 gene to outside databases

    Publications
    for IGF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGF1 gene, integrated from 9 sources (see all 6972):
    (articles sorted by number of sources associating them with IGF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of cDNA encoding human insulin-like growth factor I precursor. (PubMed id 6358902)1, 2, 3 Jansen M.... van den Brande J.L. (1983)
    2. A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels. (PubMed id 12590635)1, 4, 9 Rietveld I....Lamberts S.W. (2003)
    3. Polymorphisms in the IGF-1 and IGFBP 3 promoter and the risk of breast cancer. (PubMed id 15986122)1, 4, 9 Wagner K....Forsti A. (2005)
    4. A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects. (PubMed id 15302607)1, 4, 9 Nielsen E.M....Pedersen O. (2004)
    5. Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review. (PubMed id 15668470)1, 4, 9 Fletcher O....Silva I.d.o.s. .S. (2005)
    6. Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer. (PubMed id 15247132)1, 4, 9 Slattery M.L....Neuhausen S. (2004)
    7. IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men. (PubMed id 15734965)1, 4, 9 Schildkraut J.M....Walther P.J. (2005)
    8. Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: strong association of IRS1 G972R variant and cancer risk. (PubMed id 15678496)1, 4, 9 Neuhausen S.L....Brothman A.R. (2005)
    9. An IGF-I promoter polymorphism modifies the relationships between birth weight and risk factors for cardiovascular disease and diabetes at age 36. (PubMed id 15927083)1, 4, 9 te Velde S.J....Kemper H.C. (2005)
    10. CA repeat polymorphism in the insulin-like growth factor-I gene is associated with increased risk of prostate cancer and benign prostatic hyperplasia. (PubMed id 15586244)1, 4, 9 Tsuchiya N....Habuchi T. (2005)

    External Searches for IGF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IGF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3479 HGNC: 5464 AceView: IGF1 Ensembl:ENSG00000017427 euGenes: HUgn3479
    ECgene: IGF1 Kegg: 3479 H-InvDB: IGF1

    Other Databases showing IGF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGF1 Genetics and Cytogenetics in Oncology and Haematology
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HLA-DQB1
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igf1/
    Wikipedia http://en.wikipedia.org/wiki/Insulin-like_growth_factor_1

    Intellectual Property
    for IGF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGF1 gene:
    Search GeneIP for patents involving IGF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IGF1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of IGF1
     EMD Millipore Purified and/or Recombinant IGF1 Protein
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of IGF1
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IGF1 (IGF-I)   Browse Cell Culture Products  
     ELISAs for IGF1 (IGF-I)   Flow Cytometry Kits for IGF1 (IGF-I)  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for IGF1 (IGF-I)  
     OriGene Antibodies for IGF1   OriGene shRNA RFP for IGF1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGF1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGF1  
     OriGene Protein Over-expression Lysate for IGF1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for IGF1   OriGene 3'-UTR Clone for IGF1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGF1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGF1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for IGF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IGF1   OriGene Custom Protein Services for IGF1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGF1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGF1
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGF1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGF1
     GenScript Purified and Recombinant Proteins for IGF1 GenScript cDNA clones with any tag delivered in your preferred vector for IGF1
     GenScript Custom Assay Services for IGF1 GenScript Custom Superior Antibodies Services for IGF1
     GenScript Custom overexpressing Cell Line Services for IGF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IGF1 promoter
     Search Chromatin IP Primers for IGF1
     RT2 qPCR Primer Assay in human, mouse, rat IGF1
     GNC Network for IGF1
     SABiosciences PCR Arrays including human, mouse, rat IGF1
     Tocris compounds for IGF1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Assays/Drugs/Proteins for IGF1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IGF1 antibodies
     IGF1 proteins
     IGF1 lysates
     Antibodies for IGF1
     See all of Abcam's Antibodies, Kits and Proteins for IGF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for IGF1




     IGF1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for IGF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IGF1
     SwitchGear Promoter luciferase reporter plasmids for IGF1
     ThermoFisher Antibody for IGF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      IGF1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4