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IGF1 Gene

protein-coding   GIFtS: 72
GCID: GC12M102748

Insulin-Like Growth Factor 1 (Somatomedin C)

  See IGF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin-Like Growth Factor 1 (Somatomedin C)1 2     IGFI2
Mechano Growth Factor2 3     Insulin-Like Growth Factor I2
IGF-I2 3     Insulin-Like Growth Factor IA2
MGF2 3     Insulin-Like Growth Factor IB2
IGF-IA2     somatomedin-C2
IGF-IB2     IBP13
IGF1A2     Somatomedin-C3

External Ids:    HGNC: 54641   Entrez Gene: 34792   Ensembl: ENSG000000174277   OMIM: 1474405   UniProtKB: P050193   

Export aliases for IGF1 gene to outside databases

Previous GC identifers: GC12M101888 GC12M101292 GC12M099849


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGF1 Gene:
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of
proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound
by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I
deficiency. Several transcript variants encoding different isoforms have been found for this gene.(provided by
RefSeq, Mar 2009)

GeneCards Summary for IGF1 Gene:
IGF1 (insulin-like growth factor 1 (somatomedin C)) is a protein-coding gene. Diseases associated with IGF1 include slipped capital femoral epiphysis, and peho syndrome. GO annotations related to this gene include integrin binding and growth factor activity. An important paralog of this gene is IGF2.

UniProtKB/Swiss-Prot: IGF1_HUMAN, P05019
Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to
insulin but have a much higher growth-promoting activity. May be a physiological regulator of
[1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in
rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only
regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse
maturation

summary for IGF1 Gene:
Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each
of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular
tyrosine kinase activity. IR homodimers are activated by insulin and in adults, mediate an increase in
glucose uptake through upregulation of Glut4 expression. Two isoforms of the IR exist; fetal IR-A and adult
IR-B. IGF1R homodimers are activated by IGF-I and IGF-II and mediate pre- and postnatal growth. IGF2R
sequesters IGF-II and acts to regulate its levels. IR-IGF1R heterodimers exist and, like IGF1R homodimers,
are activated by IGF-I and IGF-II. IRs and IGFRs mediate their intracellular actions through the PI 3-K and
RAS/RAF/MAPK signaling pathways and downstream effectors include mTOR, p70 S6 kinase, ERK and JNK. Many
tumors have altered expression of IGF1R and its ligands and this constitutes an early, possible initiating,
event in tumorigenesis. Decreases in IR signaling causing insulin resistance is a major component in the
development of type 2 diabetes and congenital mutations in the IR can cause the fatal Donohue syndrome.

Gene Wiki entry for IGF1 (Insulin-like growth factor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGF1 gene promoter:
         STAT5B   SRF   C/EBPbeta   SRF (504 AA)   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGF1 promoter sequence
   Search Chromatin IP Primers for IGF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.2

IGF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M102748:  view genomic region     (about GC identifiers)

Start:
102,789,645 bp from pter      End:
102,874,423 bp from pter
Size:
84,779 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IGF1_HUMAN, P05019 (See protein sequence)
Recommended Name: Insulin-like growth factor I precursor  
Size: 195 amino acids; 21841 Da
Sequence caution: Sequence=CAA27250.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for IGF1 (see all 18):
1B9G (3D)        1BQT (3D)        1GF1 (3D)        1GZR (3D)        1GZY (3D)        1GZZ (3D)    
Secondary accessions: B2RWM7 E9PD02 P01343 Q14620
Alternative splicing: 4 isoforms:  P05019-1   P05019-2   P05019-3   P05019-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for IGF1: NX_P05019

Explore proteomics data for IGF1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IGF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000609.1  NP_001104753.1  NP_001104754.1  NP_001104755.1  

    ENSEMBL proteins: 
     ENSP00000337612   ENSP00000376637   ENSP00000416811   ENSP00000376638   ENSP00000302665  
     ENSP00000394999  
    Reactome Protein details: P05019

    IGF1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for IGF1
    OriGene MassSpec for IGF1
    OriGene Custom Protein Services for IGF1
    GenScript Purified and Recombinant Proteins for IGF1
    Novus Biologicals IGF1 Proteins
    Novus Biologicals IGF1 Lysates
    Sino Biological Recombinant Protein for IGF1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IGF1
    Cloud-Clone Corp. Proteins for IGF1

     
    Search eBioscience for Proteins for IGF1 

    IGF1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IGF1
    R&D Systems Antibodies for IGF1 (IGF-I)
    OriGene Antibodies for IGF1
    OriGene Custom Antibody Services for IGF1
    Novus Biologicals IGF1 Antibodies
    Abcam antibodies for IGF1
    Cloud-Clone Corp. Antibodies for IGF1
    ThermoFisher Antibody for IGF1
    LSBio Antibodies in human, mouse, rat for IGF1

    IGF1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of IGF1
    OriGene Custom Assay Services for IGF1
    R&D Systems Flow Cytometry Kits for IGF1 (IGF-I)         (see all)
    GenScript Custom Assay Services for IGF1
    Enzo Life Sciences assays for IGF1
    Cloud-Clone Corp. ELISAs for IGF1
    Cloud-Clone Corp. CLIAs for IGF1
    Search eBioscience for ELISAs for IGF1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR016179 Insulin-like
     IPR022350 Insulin-like_growth_factor
     IPR022352 Insulin_family
     IPR022353 Insulin_CS
     IPR022341 IGF-I

    Graphical View of Domain Structure for InterPro Entry P05019

    ProtoNet protein and cluster: P05019

    1 Blocks protein domain: IPB004825 Insulin/IGF/relaxin

    UniProtKB/Swiss-Prot: IGF1_HUMAN, P05019
    Similarity: Belongs to the insulin family


    Find genes that share domains with IGF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IGF1_HUMAN, P05019
    Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to
    insulin but have a much higher growth-promoting activity. May be a physiological regulator of
    [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in
    rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only
    regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse
    maturation

         Genatlas biochemistry entry for IGF1:
    insulin-like growth factor 1,expressed in liver,regulator of somatic growth and cellular proliferation,inducer of
    the phosphatidylinositol 3-kinase survival pathway through activation of AKT1,AKT2,inhibited by TNF in its
    neuroprotective role,also inducer of calcineurin mediated signaling and activation of GATA2,associated with
    intrauterine growth retardation and severe short stature in a patient carrying a homozygous deletion of IGF1

         Summary: 
    During embryonic development, IGF1 as signaling molecule is secreted from the following cells:
          selected tissues (see all 5)      fully expand
    Bone: Prechondrocytes (Stylopod Epiphyseal End), Prechondrocytes (Zeugopod Epiphyseal End)      fully expand to see all 5 cells
    Cartilage: Prechondrocytes (Synchondroses), Prechondrocytes (Rostral Synchondroses)      fully expand to see all 2 cells

    It affects the following cells:
          selected tissues (see all 5)      fully expand
    Bone: Immature Endochondral Osteoblasts (Rostral Endochondral Facial Bones), Endochondral Preosteoblasts (Caudal Endochondral Bones)      fully expand to see all 8 cells
    Liver: Hepatic Stellate Cells (Sinusoids)

    IGF1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 12)      fully expand
    Spinal Cord: Motor neuron-like cells, Precursor lateral motor column neuron EBs      fully expand to see all 11 cells
    Brain: Oligodendrocyte-like cells , Oligodendrocyte precursor cells      fully expand to see all 7 cells

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005158insulin receptor binding IPI8452530
    GO:0005159insulin-like growth factor receptor binding IPI8452530
    GO:0005178integrin binding IDA19578119
    GO:0005179hormone activity IDA7188854
    GO:0005515protein binding IPI10766744
         
    Find genes that share ontologies with IGF1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IGF1:
     Decreased viability with pacli  Synthetic lethal with c-Myc af 

         Selected MGI mutant phenotypes (inferred from 9 alleles(MGI details for Igf1) (see all 20):
     adipose tissue  cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    Find genes that share phenotypes with IGF1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IGF1: Igf1tm1.1Nros Igf1tm2.1Nros Igf1tm1Arge Igf1tm2Ts Igf1tm1.1Dlr Igf1tm1Ts

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IGF1:
    hsa-mir-27a-3p (MIRT006431)

    Block miRNA regulation of human, mouse, rat IGF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGF1 (see all 170):
    hsa-miR-361-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-519a hsa-miR-1243 hsa-miR-508-5p hsa-miR-130b hsa-miR-374b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IGF1
    Predesigned siRNA for gene silencing in human, mouse, rat IGF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IGF1

    Clone
    Products:
         
    OriGene clones in human, mouse for IGF1 (see all 25)
    OriGene ORF clones in mouse, rat for IGF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): IGF1 (NM_001111283)
    Sino Biological Human cDNA Clone for IGF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IGF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13203) for IGF1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGF1_HUMAN, P05019: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    endoplasmic reticulum3
    nucleus3
    cytoskeleton2
    cytosol2
    mitochondrion2
    golgi apparatus1
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA17119061
    GO:0005886plasma membrane TAS--
    GO:0016942insulin-like growth factor binding protein complex IC10766744
    GO:0031093platelet alpha granule lumen TAS--

    Find genes that share ontologies with IGF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGF1 About   (see all 60)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    2Translation Insulin regulation of translation
    Transcription Receptor mediated HIF regulation0.51
    mTOR signaling pathway0.34
    3Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59


    Find genes that share SuperPaths with IGF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IGF1 (see all 63)
        Nuclear Receptor Activation by Vitamin-A
    RhoA Pathway
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis

    Selected GeneGo (Thomson Reuters) Pathways for IGF1 (see all 10)
        Transcription Androgen Receptor nuclear signaling
    Apoptosis and survival Caspase cascade
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    Signal transduction PTEN pathway

    Selected BioSystems Pathways for IGF1 (see all 9)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Apoptosis
    Senescence and Autophagy
    Adipogenesis


    Selected Reactome Pathways for IGF1 (see all 6)
        Synthesis, secretion, and deacylation of Ghrelin
    Platelet degranulation
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    IRS-related events triggered by IGF1R
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)


    Selected Kegg Pathways  (Kegg details for IGF1) (see all 22):
        Ras signaling pathway
    Rap1 signaling pathway
    HIF-1 signaling pathway
    FoxO signaling pathway
    Oocyte meiosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGF1 (see all 27): 
              TGFB/BMP Signaling Pathway in human mouse rat
              Wound Healing in human mouse rat
              Autophagy in human mouse rat
              Prostate Cancer in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IGF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IGF1 (P050192, 3 ENSP000003026654) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGFBP4P226923, ENSP000002695934I2D: score=4 STRING: ENSP00000269593
    IGFBP5P245933, ENSP000002338134I2D: score=4 STRING: ENSP00000233813
    IGFBP7Q162703, ENSP000002956664I2D: score=3 STRING: ENSP00000295666
    IGFBP1P088333, ENSP000002755254I2D: score=2 STRING: ENSP00000275525
    NOVP487453, ENSP000002595264I2D: score=2 STRING: ENSP00000259526
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 80):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS10448861
    GO:0001932regulation of protein phosphorylation ----
    GO:0001974blood vessel remodeling IEA--
    GO:0002576platelet degranulation TAS--
    GO:0006260DNA replication TAS10766744

    Find genes that share ontologies with IGF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for IGF1
      Browse compounds at ApexBio 

    Compounds for IGF1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PicropodophyllotoxinSelective IGF1R inhibitor[477-47-4]
    Demethylasterriquinone B1Selective insulin RTK activator[78860-34-1]
    BMS 536924Dual IR/IGF1R inhibitor[468740-43-4]
    Insulin (human) recombinantEndogenous peptide agonist[11061-68-0]

    2 DrugBank Compounds for IGF1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Deoxy-Bigchap-- --target--17139284 17016423 10592235
    N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for IGF1 gene (see all 128)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pegvisomant 89 252 17077131 (7), 18498055 (5), 17289896 (5), 20009494 (5) (see all 99)
    octreotide 85.1 486 7535670 (7), 1547711 (7), 19141605 (6), 10468985 (5) (see all 99)
    lanreotide 84 113 10090136 (5), 8921789 (5), 10468985 (3), 10822218 (3) (see all 60)
    testosterone 80 1491 7486812 (7), 15240605 (7), 15978972 (7), 15713723 (6) (see all 99)
    glucose 79.3 1963 8297333 (8), 9651378 (7), 7510305 (6), 12186455 (6) (see all 99)
    estradiol 77.6 695 9626134 (8), 17618061 (6), 19085695 (6), 18498055 (5) (see all 99)
    dehydroepiandrosterone sulfate 74.8 382 17381481 (9), 9100552 (7), 8401752 (7), 10487697 (6) (see all 99)
    phosphatidylinositol 70.9 247 9886492 (5), 1311242 (5), 10707862 (4), 10436165 (3) (see all 99)
    c-peptide 70.1 230 12794762 (4), 7510305 (4), 14770423 (4), 17679371 (4) (see all 99)
    ly294002 69.3 102 17164836 (2), 11145583 (2), 17093064 (2), 10412024 (2) (see all 81)



    Find genes that share compounds with IGF1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IGF1 gene (4 alternative transcripts): 
    NM_000618.3  NM_001111283.1  NM_001111284.1  NM_001111285.1  

    Unigene Cluster for IGF1:

    Insulin-like growth factor 1 (somatomedin C)
    Hs.160562  [show with all ESTs]
    Unigene Representative Sequence: JX088243
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337514 ENST00000481539 ENST00000392904 ENST00000424202 ENST00000392905
    ENST00000307046(uc001tjp.4) ENST00000456098(uc001tjn.2 uc001tjm.2 uc001tjo.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat IGF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGF1 (see all 170):
    hsa-miR-361-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-519a hsa-miR-1243 hsa-miR-508-5p hsa-miR-130b hsa-miR-374b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IGF1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): IGF1 (NM_001111283)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGF1
    Primer
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    OriGene qPCR primer pairs and template standards for IGF1
    OriGene qSTAR qPCR primer pairs in human, mouse for IGF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IGF1
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13203) for IGF1 

    Additional mRNA sequence: 

    AB209184.1 AK312231.1 BC148266.1 BC152321.1 CR541861.1 JX088243.1 M11568.1 M27544.1 
    M29644.1 M37484.1 U40870.1 X00173.1 X56773.1 X56774.1 X57025.1 

    12 DOTS entries:

    DT.454558  DT.92461093  DT.100680034  DT.75105093  DT.92046813  DT.92070424  DT.92070425  DT.95275111 
    DT.100659724  DT.95149146  DT.40304132  DT.95184323 

    Selected AceView cDNA sequences (see all 161):

    AI248089 AI457887 BQ773809 AA703492 H88012 BF438381 AI678264 X56773 
    BF589728 AA580109 BQ006168 CA445905 BQ786970 AL708718 BX281850 CR541861 
    BQ024203 X56774 AI478804 AW517507 AW204378 U40870 AU118321 AL709516 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IGF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGF1 Expression
    About this image


    IGF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 25) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 20 entries
             Endochondral Osteoblasts Rostral Endochondral Facial Bones
             Zeugopod Epiphyseal End
             Mesenchymal Precursor Cells (STRO-3 selected)
     
     Cartilage (Muscoskeletal System)    fully expand to see all 10 entries
             Prechondrocytes Synchondroses
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
             Human neonatal dermal fibroblasts (Dermagraft)
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Midbrain tegmentum
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
    IGF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.160562
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGF1 (see all 27): 
              TGFB/BMP Signaling Pathway in human mouse rat
              Wound Healing in human mouse rat
              Autophagy in human mouse rat
              Prostate Cancer in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for IGF1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igf11 , 5 insulin-like growth factor 11, 5 88.67(n)1
    91.5(a)1
      10 (43.70 cM)5
    160001  NM_001111275.11  NP_001104745.11 
     878582655 
    chicken
    (Gallus gallus)
    Aves IGF11 insulin-like growth factor 1 (somatomedin C) 80.61(n)
    84.31(a)
      418090  NM_001004384.2  NP_001004384.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGF16
    insulin-like growth factor 1 (somatomedin C)
    64(a)
    1 ↔ 1
    5(17591808-17673963)
    African clawed frog
    (Xenopus laevis)
    Amphibia igf1-A2 insulin-like growth factor 1 (somatomedin C) 82.94(n)    M29857.1 
    zebrafish
    (Danio rerio)
    Actinopterygii igf12 insulin-like growth factor 1 77.48(n)   114433  AF268051.1 


    ENSEMBL Gene Tree for IGF1 (if available)
    TreeFam Gene Tree for IGF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGF1 gene
    IGF22  
    3 SIMAP similar genes for IGF1 using alignment to 6 protein entries:     IGF1_HUMAN (see all proteins):
    IGF-I    IGF2    INS

    Find genes that share paralogs with IGF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGF1 (see all 1643)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907316781,2
    C--99853294(+) GGAGTC/TTTTTT 3 -- ut310--------
    rs676932691,2
    C--99856811(+) TTTTT-/T/TTTT
            
    GTAGA
    3 -- int11NA 2
    rs566758771,2
    C--99870366(+) GAAGAAGA/-GTGCA 4 -- cds11Minor allele frequency- -:0.00NA 2
    rs351409681,2
    C--99875846(+) TTGAG-/AT/TA 
            
    AGTTA
    4 -- int10--------
    rs1414364401,2
    C--99901900(+) ATAAT-/AAAAA 
            
    AAAAA
    4 -- int10--------
    rs58005121,2
    C--99933287(+) AAAAGA/-AAAAA 4 -- int1 us2k1 trp31Minor allele frequency- -:0.00CSA 2
    rs57427191,2
    H--102629408(-) TTCACA/GACAGC 3 -- ds50015Minor allele frequency- G:0.00NS EA 590
    rs57427181,2
    H--102629449(-) TCGTTC/TCAATT 3 -- ds50015Minor allele frequency- T:0.00NS EA 596
    rs1891054141,2
    --102629530(+) ATGCCA/CTTTAT 3 -- ds50010--------
    rs57427171,2
    C,F,H--102629581(-) AAATAT/CTCTAT 3 -- ds50015Minor allele frequency- C:0.00NS EA 600

    HapMap Linkage Disequilibrium report for IGF1 (102789645 - 102874423 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for IGF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663083CNV Deletion23128226
    esv273493CNV Insertion20981092
    esv271788CNV Insertion20981092
    nsv832499CNV Gain17160897
    nsv832498CNV Gain17160897
    nsv819617CNV Gain19587683
    nsv899474CNV Gain21882294

    Human Gene Mutation Database (HGMD): IGF1
    Locus Specific Mutation Databases (LSDB): IGF1

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IGF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 147440   
    OMIM disorders: 608747  
    UniProtKB/Swiss-Prot: IGF1_HUMAN, P05019
  • Insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]: Autosomal recessive disorder
    characterized by growth retardation, sensorineural deafness and mental retardation. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for IGF1 (see all 65):    
    About MalaCards
    slipped capital femoral epiphysis    peho syndrome    growth retardation with deafness and mental retardation due to igf1 deficiency    neonatal progeroid syndrome
    laron syndrome    insulin-like growth factor i deficiency    currarino triad    osteochondrosis
    obstructive hydrocephalus    ring chromosome 15    l1 syndrome    glycogen storage disease type 1a
    rabson-mendenhall syndrome    diffuse idiopathic skeletal hyperostosis    growth hormone secreting pituitary adenoma    sheehan syndrome
    acid-labile subunit deficiency    donohue syndrome    acromegaly    dysentery

    Selected diseases from the University of Copenhagen DISEASES database for IGF1 (see all 38):
    Acromegaly     Diabetes mellitus     Hypopituitarism     Osteoporosis
    Breast cancer     Pituitary adenoma     Hyperinsulinism     Hypoglycemia
    Adenoma     Turner syndrome     Hyperglycemia     Prostate cancer
    Hypogonadism     Kidney failure     Polycystic ovary syndrome     Hypothyroidism
    Hypertension     Myopathy     Retinopathy of prematurity     Autosomal recessive disease

    Find genes that share disorders with IGF1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IGF1 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acromegaly 95.5 943 17575366 (7), 17047383 (6), 7586626 (5), 17431794 (5) (see all 99)
    laron syndrome 89.9 231 14510912 (4), 19117781 (3), 1281024 (3), 10392360 (3) (see all 99)
    growth hormone deficiency 89.6 172 10435854 (6), 8279222 (4), 7904496 (4), 8657365 (4) (see all 96)
    short stature 86.1 289 11155089 (4), 18165284 (4), 10848878 (3), 16820702 (3) (see all 99)
    growth failure 82 113 1919980 (3), 2155253 (2), 7794630 (2), 10359158 (2) (see all 68)
    igf-i resistance 80.5 74 15476454 (3), 8809343 (3), 19046909 (2), 8964861 (2) (see all 35)
    hypopituitarism 80.1 55 17121519 (2), 19226273 (2), 19020378 (2), 1283982 (2) (see all 37)
    pituitary adenoma 77.1 46 19472104 (3), 7691862 (2), 14710344 (2), 16926522 (2) (see all 31)
    insulin resistance 75.5 327 17953765 (5), 9663927 (5), 19902049 (4), 18335323 (3) (see all 99)
    growth retardation 74.8 144 11207641 (4), 9795360 (3), 9364353 (3), 2394775 (2) (see all 98)

    Genetic Association Database (GAD): IGF1
    Human Genome Epidemiology (HuGE) Navigator: IGF1 (289 documents)
    Tumor Gene Database (TGDB): IGF1

    Export disorders for IGF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for IGF1 gene, integrated from 10 sources (see all 7082):
    (articles sorted by number of sources associating them with IGF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of cDNA encoding human insulin-like growth factor I precursor. (PubMed id 6358902)1, 2, 3 Jansen M.... van den Brande J.L. (Nature 1983)
    2. Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels. (PubMed id 17911177)1, 4, 9 Johansson M....Kaaks R. (J. Clin. Endocrinol. Metab. 2007)
    3. Insulin-like growth factor-1 genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating insulin-like growth factor-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families. (PubMed id 17010055)1, 4, 9 JernstrAPm H....Olsson H. (Int. J. Gynecol. Cancer 2006)
    4. A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels. (PubMed id 12590635)1, 4, 9 Rietveld I....Lamberts S.W. (Eur. J. Endocrinol. 2003)
    5. IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 18596909)1, 4, 9 Patel A.V....Feigelson H.S. (PLoS ONE 2008)
    6. Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer. (PubMed id 17096324)1, 4, 9 Johansson M....Kaaks R. (Int. J. Cancer 2007)
    7. Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort. (PubMed id 16418515)1, 4, 9 Cheng I....Freedman M.L. (J. Natl. Cancer Inst. 2006)
    8. IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. (PubMed id 16306136)1, 4, 9 Al-Zahrani A....Dunning A.M. (Hum. Mol. Genet. 2006)
    9. Insulin-like growth factor-I gene polymorphism and breast cancer risk in Chinese women. (PubMed id 15386404)1, 4, 9 Wen W....Zheng W. (Int. J. Cancer 2005)
    10. IGF1 genotype, mean plasma level and breast cancer risk in the Hawaii/Los Angeles multiethnic cohort. (PubMed id 12610514)1, 4, 9 DeLellis K....Probst-Hensch N.M. (Br. J. Cancer 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3479 HGNC: 5464 AceView: IGF1 Ensembl:ENSG00000017427 euGenes: HUgn3479
    ECgene: IGF1 Kegg: 3479 H-InvDB: IGF1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IGF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGF1 Genetics and Cytogenetics in Oncology and Haematology
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HLA-DQB1
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igf1/
    Wikipedia http://en.wikipedia.org/wiki/Insulin-like_growth_factor_1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGF1 gene:
    Search GeneIP for patents involving IGF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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