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Aliases for IGF1 Gene

Aliases for IGF1 Gene

  • Insulin-Like Growth Factor 1 (Somatomedin C) 2 3
  • Mechano Growth Factor 3 4
  • Somatomedin-C 3 4
  • IGF-I 3 4
  • MGF 3 4
  • Insulin-Like Growth Factor IA 3
  • Insulin-Like Growth Factor IB 3
  • Insulin-Like Growth Factor I 3
  • IGF-IA 3
  • IGF-IB 3
  • IGF1A 3
  • IBP1 4
  • IGFI 3

External Ids for IGF1 Gene

Summaries for IGF1 Gene

Entrez Gene Summary for IGF1 Gene

  • The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

GeneCards Summary for IGF1 Gene

IGF1 (Insulin-Like Growth Factor 1 (Somatomedin C)) is a Protein Coding gene. Diseases associated with IGF1 include slipped capital femoral epiphysis and growth retardation with deafness and mental retardation due to igf1 deficiency. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include growth factor activity and integrin binding. An important paralog of this gene is IGF2.

UniProtKB/Swiss-Prot for IGF1 Gene

  • The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.

Tocris Summary for IGF1 Gene

  • Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IR homodimers are activated by insulin and in adults, mediate an increase in glucose uptake through upregulation of Glut4 expression. Two isoforms of the IR exist; fetal IR-A and adult IR-B. IGF1R homodimers are activated by IGF-I and IGF-II and mediate pre- and postnatal growth. IGF2R sequesters IGF-II and acts to regulate its levels. IR-IGF1R heterodimers exist and, like IGF1R homodimers, are activated by IGF-I and IGF-II. IRs and IGFRs mediate their intracellular actions through the PI 3-K and RAS/RAF/MAPK signaling pathways and downstream effectors include mTOR, p70 S6 kinase, ERK and JNK. Many tumors have altered expression of IGF1R and its ligands and this constitutes an early, possible initiating, event in tumorigenesis. Decreases in IR signaling causing insulin resistance is a major component in the development of type 2 diabetes and congenital mutations in the IR can cause the fatal Donohue syndrome.

Gene Wiki entry for IGF1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF1 Gene

Genomics for IGF1 Gene

Genomic Location for IGF1 Gene

Start:
102,395,867 bp from pter
End:
102,480,645 bp from pter
Size:
84,779 bases
Orientation:
Minus strand

Genomic View for IGF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF1 Gene

Regulatory Elements for IGF1 Gene

Proteins for IGF1 Gene

  • Protein details for IGF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05019-IGF1_HUMAN
    Recommended name:
    Insulin-like growth factor I
    Protein Accession:
    P05019
    Secondary Accessions:
    • B2RWM7
    • E9PD02
    • P01343
    • Q14620

    Protein attributes for IGF1 Gene

    Size:
    195 amino acids
    Molecular mass:
    21841 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA27250.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGF1 Gene

    Alternative splice isoforms for IGF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGF1 Gene

Proteomics data for IGF1 Gene at MOPED

Post-translational modifications for IGF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGF1 Gene

No data available for DME Specific Peptides for IGF1 Gene

Domains for IGF1 Gene

Gene Families for IGF1 Gene

HGNC:

Protein Domains for IGF1 Gene

UniProtKB/Swiss-Prot:

IGF1_HUMAN
Family:
  • Belongs to the insulin family.:
    • P05019
genes like me logo Genes that share domains with IGF1: view

Function for IGF1 Gene

Molecular function for IGF1 Gene

GENATLAS Biochemistry: insulin-like growth factor 1,expressed in liver,regulator of somatic growth and cellular proliferation,inducer of the phosphatidylinositol 3-kinase survival pathway through activation of AKT1,AKT2,inhibited by TNF in its neuroprotective role,also inducer of calcineurin mediated signaling and activation of GATA2,associated with intrauterine growth retardation and severe short stature in a patient carrying a homozygous deletion of IGF1
UniProtKB/Swiss-Prot Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.

LifeMap Function Summary for IGF1 Gene

IGF1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005158 insulin receptor binding IPI 8452530
GO:0005159 insulin-like growth factor receptor binding IPI 8452530
GO:0005178 integrin binding IDA 19578119
GO:0005179 hormone activity IDA 7188854
GO:0005515 protein binding IPI 10766744
genes like me logo Genes that share ontologies with IGF1: view
genes like me logo Genes that share phenotypes with IGF1: view

Animal Models for IGF1 Gene

MGI Knock Outs for IGF1:

miRNA for IGF1 Gene

miRTarBase miRNAs that target IGF1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IGF1 Gene

Localization for IGF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGF1 Gene COMPARTMENTS Subcellular localization image for IGF1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 3
nucleus 3
cytoskeleton 2
cytosol 2
mitochondrion 2
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 11404306
GO:0005886 plasma membrane TAS --
GO:0016942 insulin-like growth factor binding protein complex IC 10766744
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with IGF1: view

Pathways for IGF1 Gene

genes like me logo Genes that share pathways with IGF1: view

Gene Ontology (GO) - Biological Process for IGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 10448861
GO:0001775 cell activation IDA 22797923
GO:0001932 regulation of protein phosphorylation --
GO:0001974 blood vessel remodeling IEA --
GO:0002576 platelet degranulation TAS --
genes like me logo Genes that share ontologies with IGF1: view

Compounds for IGF1 Gene

(4) Tocris Compounds for IGF1 Gene

Compound Action Cas Number
BMS 536924 Dual IR/IGF1R inhibitor [468740-43-4]
Demethylasterriquinone B1 Selective insulin RTK activator [78860-34-1]
Insulin (human) recombinant Endogenous peptide agonist [11061-68-0]
Picropodophyllotoxin Selective IGF1R inhibitor [477-47-4]

(2) Drugbank Compounds for IGF1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Deoxy-Bigchap
target
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
target

(128) Novoseek inferred chemical compound relationships for IGF1 Gene

Compound -log(P) Hits PubMed IDs
pegvisomant 89 178
octreotide 85.1 248
lanreotide 84 98
testosterone 80 359
glucose 79.3 357
genes like me logo Genes that share compounds with IGF1: view

Transcripts for IGF1 Gene

Unigene Clusters for IGF1 Gene

Insulin-like growth factor 1 (somatomedin C):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGF1 Gene

No ASD Table

Relevant External Links for IGF1 Gene

GeneLoc Exon Structure for
IGF1
ECgene alternative splicing isoforms for
IGF1

Expression for IGF1 Gene

mRNA expression in normal human tissues for IGF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGF1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IGF1 Gene

SOURCE GeneReport for Unigene cluster for IGF1 Gene Hs.160562

genes like me logo Genes that share expressions with IGF1: view

Orthologs for IGF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGF1 36
  • 100 (n)
  • 100 (a)
IGF1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGF-I 37
  • 89 (a)
OneToOne
IGF1 36
  • 93.46 (n)
  • 96.08 (a)
dog
(Canis familiaris)
Mammalia IGF1 36
  • 93.68 (n)
  • 97.39 (a)
IGF1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igf1 36
  • 88.67 (n)
  • 91.5 (a)
Igf1 16
Igf1 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGF1 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGF1 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igf1 36
  • 88.02 (n)
  • 92.81 (a)
chicken
(Gallus gallus)
Aves IGF1 36
  • 80.61 (n)
  • 84.31 (a)
IGF1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGF1 37
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia igf1-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486334 36
  • 77.56 (n)
  • 79.74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11904 36
zebrafish
(Danio rerio)
Actinopterygii igf1 36
  • 67.36 (n)
  • 65.97 (a)
igf1 37
  • 53 (a)
OneToOne
Species with no ortholog for IGF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGF1 Gene

ENSEMBL:
Gene Tree for IGF1 (if available)
TreeFam:
Gene Tree for IGF1 (if available)

Paralogs for IGF1 Gene

Paralogs for IGF1 Gene

Selected SIMAP similar genes for IGF1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IGF1: view

Variants for IGF1 Gene

Sequence variations from dbSNP and Humsavar for IGF1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs6212 -- 102,400,783(-) GTTAG(C/G/T)ACTCA utr-variant-3-prime
rs6213 - 102,417,846(-) AAATG(A/C)TGAAT intron-variant, missense, reference
rs6214 -- 102,399,791(-) TTAAC(A/G)TGTTT utr-variant-3-prime
rs6215 -- 102,396,196(-) AAGTG(C/T)GATAA utr-variant-3-prime
rs6216 -- 102,400,241(-) GCAAA(C/G/T)TCTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IGF1 Gene

Variant ID Type Subtype PubMed ID
nsv899474 CNV Gain 21882294
nsv832498 CNV Gain 17160897
nsv819617 CNV Gain 19587683
nsv832499 CNV Gain 17160897
esv2663083 CNV Deletion 23128226
esv271788 CNV Insertion 20981092
esv273493 CNV Insertion 20981092

Relevant External Links for IGF1 Gene

HapMap Linkage Disequilibrium report
IGF1
Human Gene Mutation Database (HGMD)
IGF1
Locus Specific Mutation Databases (LSDB)
IGF1

Disorders for IGF1 Gene

(1) OMIM Diseases for IGF1 Gene (147440)

UniProtKB/Swiss-Prot

IGF1_HUMAN
  • Insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]: Autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. {ECO:0000269 PubMed:8857020}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(92) Novoseek inferred disease relationships for IGF1 Gene

Disease -log(P) Hits PubMed IDs
acromegaly 95.5 299
laron syndrome 89.9 153
growth hormone deficiency 89.6 126
short stature 86.1 145
growth failure 82 78

Relevant External Links for IGF1

Genetic Association Database (GAD)
IGF1
Human Genome Epidemiology (HuGE) Navigator
IGF1
Tumor Gene Database (TGDB):
IGF1
genes like me logo Genes that share disorders with IGF1: view

Publications for IGF1 Gene

  1. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. (PMID: 8857020) Woods K.A. … Clark A.J. (N. Engl. J. Med. 1996) 3 4 23
  2. Genetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women. (PMID: 11319179) JernstrAPm H. … Pollak M. (Cancer Epidemiol. Biomarkers Prev. 2001) 3 23 49
  3. A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction. (PMID: 11246885) Vaessen N. … van Duijn C.M. (Diabetes 2001) 3 23 49
  4. Polymorphic CA repeats in the IGF-I gene and breast cancer. (PMID: 11768601) Yu H. … Kato I. (Breast Cancer Res. Treat. 2001) 3 23 49
  5. Insulin-like growth factor I polymorphism and breast cancer risk in Jewish women. (PMID: 12389335) Figer A. … Riezel S. (Isr. Med. Assoc. J. 2002) 3 23 49

Products for IGF1 Gene

Sources for IGF1 Gene

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