IGES Locus
genetic locus GIFtS: 13
GCID: GC05U990033
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immunoglobulin E concentration, serum
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Aliases
for IGES gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Immunoglobulin E Concentration, Serum1 2 |
Export aliases for IGES gene to outside databases |
Summaries
for IGES gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IGES gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IGES
Other transcription factors
Search SABiosciences Chromatin IP Primers for IGES
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGES |
Genomic Location:
Chromosome:5
Entrez Gene cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31.1GeneLoc information about chromosome 5 |
Proteins
for IGES gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for IGES gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for IGES gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
Genatlas biochemistry entry for IGES:serum immunoglobulin E level,regulator of IgE production in a nonantigen-specific fashion (noncognate),not likelyinvolved in hereditary regulation of IGE in Finnish subpopulation
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for IGES | |  | Search LifeMap BioReagents cell lines for IGES |
Pathways & Interactions
for IGES gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGES
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Drugs & Compounds
for IGES gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IGES for compounds About GeneDecksing
 Browse Tocris compounds for IGES
10/15 Novoseek chemical compound relationships for IGES gene (see all 15) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| allergens |
75.4 |
33 |
12948892 (1), 15629970 (1), 17176801 (1), 17551598 (1) (see all 30) |
| methacholine |
65.7 |
9 |
16925688 (1), 1563501 (1), 17460804 (1), 15651992 (1) (see all 6) |
| latex |
30.8 |
7 |
7919302 (1), 9676419 (1), 12436177 (1), 8677185 (1) (see all 6) |
| histamine |
27.5 |
3 |
12383204 (1), 11790650 (1) |
| gamma-linolenic acid |
26.2 |
1 |
16618360 (1) |
| cyclosporin a |
4.4 |
3 |
17725924 (1), 19840298 (1), 15692629 (1) |
| enterotoxin |
0.985 |
1 |
16224190 (1) |
| vitamin-e |
0 |
1 |
12010339 (1) |
| nitric oxide |
0 |
2 |
18097854 (1), 17189532 (1) |
| steroid |
0 |
1 |
17891348 (1) |
Search CenterWatch for drugs/clinical trials and news about IGES 
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Transcripts
for IGES gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Expression
for IGES gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for IGES
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IGES | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGES | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGES |
Orthologs
for IGES gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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Paralogs
for IGES gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IGES gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for IGES gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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IGES for disorders About GeneDecksing
OMIM gene information: 147061
OMIM disorders: --
20/86  diseases for IGES (see all 86): About MalaCardsprotein-losing enteropathy hyper-ige syndrome tyrosine kinase 2 deficiency alpha 1-antitrypsin deficiency
otitis media granulomatous angiitis polyarteritis nodosa allergic bronchopulmonary aspergillosis
orbital cellulitis plasmodium falciparum malaria myocardial infarction vernal keratoconjunctivitis
kimura disease allergic rhinitis food allergy coronary artery aneurysm
eosinophilic gastroenteritis hypereosinophilic syndrome membranoproliferative glomerulonephritis intrinsic asthma
10/56 Novoseek disease relationships for IGES gene (see all 56) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atopy |
84 |
15 |
15988535 (2), 11581439 (1), 15610365 (1), 17392323 (1) (see all 14) |
| kimura disease |
83.2 |
2 |
19468829 (1), 19620037 (1) |
| asthma |
77.4 |
60 |
15988535 (2), 11581439 (1), 11793673 (1), 11813133 (1) (see all 52) |
| allergy |
74.7 |
16 |
17176801 (1), 9042631 (1), 11821655 (1), 16950967 (1) (see all 16) |
| eosinophilia |
72.9 |
30 |
18246382 (2), 12205289 (2), 19195268 (1), 11011754 (1) (see all 25) |
| aspergillosis allergic bronchopulmonary |
72.4 |
3 |
2230542 (1), 7964167 (1), 19862941 (1) |
| dermatitis atopic |
68.7 |
9 |
17725924 (1), 15938588 (1), 19189134 (1), 12485317 (1) (see all 7) |
| hyper-ige syndrome |
66.6 |
1 |
20477605 (1) |
| asthma allergic |
65 |
1 |
8998072 (1) |
| allergic rhinitis |
64.7 |
6 |
11581439 (1), 17176801 (1), 12000480 (1), 16015268 (1) (see all 6) |
Export disorders for IGES gene to outside databases
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Publications
for IGES gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IGES gene, integrated from 9 sources (see all 284):
(articles sorted by number of sources associating them with IGES) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. (PubMed id 8178175)1, 3, 9 Marsh D.G....Beaty T.H. (1994)
- Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica. (PubMed id 11940068)1, 9 Celedon J.C....Weiss S.T. (2002)
- A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood. (PubMed id 14610476)1 Kabesch M....Martinez F.D. (2003)
- Evidence for two unlinked loci regulating total serum IgE levels. (PubMed id 7668269)1 Xu J....Meyers D.A. (1995)
- Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. (PubMed id 7835897)1 Meyers D.A....Bleecker E.R. (1994)
- Immunoglobulin E-rheumatoid factor in juvenile rheumatoid arthritis. (PubMed id 12436177)9 Ferreira R.A....Silva C.H. (2002)
- Relationship between cholinergic airway tone and serum immunoglobulin E in human subjects. (PubMed id 9701417)9 Endoh N....Shirato K. (1998)
- [Humoral immune response to tissue injury, characterized by a rise in serum immunoglobulin E] (PubMed id 8618812)9 Szczeklik A. and Jawien J. (1995)
- Serum immunoglobulin E can predict minimal change dis ease before renal biopsy. (PubMed id 19707110)9 Shao Y.N....Yang C.W. (2009)
- Cord serum immunoglobulin E as a risk factor for allergic symptoms and sensitization in children and young adults. (PubMed id 18298422)9 Pesonen M....Ranki A. (2009)
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External Searches for IGES gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing IGES gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing IGES gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IGES gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IGES | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for IGES gene:
Search GeneIP for patents involving IGES
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for IGES gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGES | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGES | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGES | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGES | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGES | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGES |
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| | | | Search Tocris compounds for IGES |
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 | | | | |  |  |  |  | | | | Search ThermoFisher Antibodies for IGES |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGES |
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