IGDCC4 Gene
protein-coding GIFtS : 46
GCID: GC15 M065673
immunoglobulin superfamily, DCC subclass, member 4
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Aliasesfor IGDCC4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Immunoglobulin Superfamily, DCC Subclass, Member 4 1 2 LOC577221 NOPE1 2 3 Immunoglobulin Superfamily DCC Subclass Member 42 Neighbor Of Punc E112 3 Likely Ortholog Of Mouse Neighbor Of Punc E112 DDM362 3 KIAA16283 HDDM361 Protein DDM363
Export aliases for IGDCC4 gene to outside databases Previous GC identifers: GC15M063461 GC15M042497
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Summariesfor IGDCC4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor IGDCC4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IGDCC4 gene promoter: Pax-5 NF-YA NF-YC CBF-C CBF-A CBF-B CP1A CP1C NF-Y CBF(2) Other transcription factors Search SABiosciences Chromatin IP Primers for IGDCC4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat IGDCC4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q22.31 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q22.31 IGDCC4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M065673: view genomic region
(about GC identifiers )
Start:
65,673,802 bp from pter
End:
65,715,410 bp from pter
Size:
41,609 bases
Orientation:
minus strand
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Proteinsfor IGDCC4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: IGDC4_HUMAN, Q8TDY8 (See
protein sequence )Recommended Name: Immunoglobulin superfamily DCC subclass member 4 precursor Size : 1250 amino acids; 134210 Da
Subcellular location : Cell membrane; Single-pass type I membrane protein (Potential)
Secondary accessions : Q9HCE4Alternative splicing : 2 isoforms : Q8TDY8-1 Q8TDY8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for IGDCC4: NX_Q8TDY8 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8TDY8 IGDCC4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_066013.1 ENSEMBL proteins: ENSP00000319623 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA -- GO:0016021 integral to membrane
IEA --
IGDCC4 for ontologies About GeneDecksing IGDCC4 Antibody Products: Assay Products for IGDCC4:
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Protein
Domains / Familiesfor IGDCC4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
IGDCC4 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8TDY8 ProtoNet protein and cluster: Q8TDY8
1 Blocks protein family : IPB003598 Immunoglobulin C-2 type UniProtKB/Swiss-Prot: IGDC4_HUMAN, Q8TDY8 Similarity : Belongs to the immunoglobulin superfamily. DCC familySimilarity : Contains 5 fibronectin type-III domainsSimilarity : Contains 4 Ig-like C2-type (immunoglobulin-like) domains
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Functionfor IGDCC4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IGDCC4 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IGDCC4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IGDCC4 (NM_020962 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGDCC4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IGDCC4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGDCC4
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Pathways & Interactionsfor IGDCC4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGDCC4 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for IGDCC4 (Q8TDY8 3 ENSP00000319623 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor IGDCC4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for IGDCC4 Search CenterWatch for drugs/clinical trials and news about IGDCC4 / IGDC4
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Transcriptsfor IGDCC4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for IGDCC4 gene: NM_020962.1 Unigene Cluster for IGDCC4:
Immunoglobulin superfamily, DCC subclass, member 4 Hs.458607 [show with all ESTs ] Unigene Representative Sequence: NM_020962 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000352385 (uc002aou.1 ) ENST00000558048 ENST00000559327 (uc002aot.1 )ENST00000561309 ENST00000560319 ENST00000558819 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IGDCC4 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IGDCC4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IGDCC4 (NM_020962 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGDCC4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IGDCC4
Additional cDNA sequence: AB046848.1 AB052622.1 AK124045.1 BC040648.1
6 DOTS entries : DT.91923456 DT.454857
DT.95366163 DT.95366162 DT.100839307 DT.102824148 24/62 AceView cDNA sequences (see all 62 ):
AA706095 AB046848 AK124045 BI766245 F13439 AA331887 NM_020962 AB052622 BF436300 AI339313 AA252900 AW954134 Z43573 CF242847 AI741225 CF593280 AA947283 BQ022893 AW663637 BE671719 AI393663 R15778 CD630475 AA385851 GeneLoc Exon Structure
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Expression for IGDCC4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section IGDCC4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATCTGTCCT
About this image IGDCC4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See IGDCC4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IGDCC4 SOURCE GeneReport for Unigene cluster: Hs.458607 SABiosciences Custom PCR Arrays for IGDCC4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IGDCC4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat IGDCC4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IGDCC4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IGDCC4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGDCC4
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Orthologsfor IGDCC4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for IGDCC4 gene from 4/13 species (see all 13 ) About this table
ENSEMBL Gene Tree for IGDCC4 (if available)TreeFam Gene Tree for IGDCC4 (if available)
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Paralogsfor IGDCC4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for IGDCC4 gene CDON 2 ROBO2 2 NEO1 2 ROBO1 2 ROBO4 2 BOC 2 DCC 2 PRTG 2 IGDCC3 2 ROBO3 2 1 SIMAP similar gene for IGDCC4 using alignment to 1 protein entry: IGDC4_HUMAN :PRTG
IGDCC4 for paralogs About GeneDecksing
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Genomic Variantsfor IGDCC4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for IGDCC4 (65673802 - 65715410 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for IGDCC4 5 CNVs : 49573 72269 49575 49574 49576
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IGDCC4
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Disorders
/ Diseasesfor IGDCC4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IGDCC4 for disorders About GeneDecksing 2 diseases for IGDCC4 : About MalaCards premature ejaculation carcinoma Export disorders for IGDCC4 gene to outside databases
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Publicationsfor IGDCC4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IGDCC4 gene integrated from 9 sources : (articles sorted by number of sources associating them with IGDCC4) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877) 1 , 2 Nagase T.... Ohara O. (2000) Neighbor of Punc E11, a novel oncofetal marker for he patocellular carcinoma. (PubMed id 20658536) 1 Marquardt J.U....Nierhoff D. (2011) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000) Cloning and expression of nope, a new mouse gene of the immunoglobulin superfamily related to guidance receptors. (PubMed id 10708514) 1 Salbaum J.M. and Kappen C. (2000)
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External Searches for IGDCC4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IGDCC4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IGDCC4 gene
(According to HUGE )
About This Section
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Specialized Databases showing IGDCC4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for IGDCC4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for IGDCC4 gene: Search GeneIP for patents involving IGDCC4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IGDCC4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for IGDCC4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for IGDCC4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IGDCC4 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for IGDCC4 OriGene 3'-UTR Clone for IGDCC4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IGDCC4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IGDCC4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for IGDCC4 OriGene Custom Protein Services for IGDCC4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGDCC4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IGDCC4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat IGDCC4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat IGDCC4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IGDCC4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IGDCC4
Search Tocris compounds for IGDCC4
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGDCC4
Search ThermoFisher Antibodies for IGDCC4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IGDCC4
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Paralogs for IGDCC4
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Proteins for IGDCC4
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