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Aliases for IGDCC4 Gene

Aliases for IGDCC4 Gene

  • Immunoglobulin Superfamily DCC Subclass Member 4 2 3
  • Immunoglobulin Superfamily, DCC Subclass, Member 4 2 3 5
  • Likely Ortholog Of Mouse Neighbor Of Punc E11 2 3
  • Neighbor Of Punc E11 3 4
  • DDM36 3 4
  • NOPE 3 4
  • Protein DDM36 4
  • KIAA1628 4
  • HDDM36 4

External Ids for IGDCC4 Gene

Previous GeneCards Identifiers for IGDCC4 Gene

  • GC15M063461
  • GC15M065673
  • GC15M042497

Summaries for IGDCC4 Gene

GeneCards Summary for IGDCC4 Gene

IGDCC4 (Immunoglobulin Superfamily DCC Subclass Member 4) is a Protein Coding gene. An important paralog of this gene is IGDCC3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGDCC4 Gene

Genomics for IGDCC4 Gene

Regulatory Elements for IGDCC4 Gene

Enhancers for IGDCC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGDCC4 on UCSC Golden Path with GeneCards custom track

Promoters for IGDCC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IGDCC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGDCC4 Gene

Chromosome:
15
Start:
65,381,464 bp from pter
End:
65,423,072 bp from pter
Size:
41,609 bases
Orientation:
Minus strand

Genomic View for IGDCC4 Gene

Genes around IGDCC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGDCC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGDCC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGDCC4 Gene

Proteins for IGDCC4 Gene

  • Protein details for IGDCC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDY8-IGDC4_HUMAN
    Recommended name:
    Immunoglobulin superfamily DCC subclass member 4
    Protein Accession:
    Q8TDY8
    Secondary Accessions:
    • Q9HCE4

    Protein attributes for IGDCC4 Gene

    Size:
    1250 amino acids
    Molecular mass:
    134210 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGDCC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGDCC4 Gene

Proteomics data for IGDCC4 Gene at MOPED

Post-translational modifications for IGDCC4 Gene

  • Glycosylation at Asn 90, Asn 102, Asn 157, Asn 252, and Asn 582
  • Modification sites at PhosphoSitePlus

Other Protein References for IGDCC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGDCC4 Gene

Domains & Families for IGDCC4 Gene

Protein Domains for IGDCC4 Gene

Suggested Antigen Peptide Sequences for IGDCC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDY8

UniProtKB/Swiss-Prot:

IGDC4_HUMAN :
  • Contains 5 fibronectin type-III domains.
  • Belongs to the immunoglobulin superfamily. DCC family.
Domain:
  • Contains 5 fibronectin type-III domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with IGDCC4: view

Function for IGDCC4 Gene

Phenotypes for IGDCC4 Gene

genes like me logo Genes that share phenotypes with IGDCC4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGDCC4

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGDCC4 Gene

Localization for IGDCC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGDCC4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGDCC4 Gene COMPARTMENTS Subcellular localization image for IGDCC4 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IGDCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGDCC4: view

Pathways & Interactions for IGDCC4 Gene

SuperPathways for IGDCC4 Gene

No Data Available

Interacting Proteins for IGDCC4 Gene

Gene Ontology (GO) - Biological Process for IGDCC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGDCC4 Gene

Drugs & Compounds for IGDCC4 Gene

No Compound Related Data Available

Transcripts for IGDCC4 Gene

Unigene Clusters for IGDCC4 Gene

Immunoglobulin superfamily, DCC subclass, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC4 Gene

No ASD Table

Relevant External Links for IGDCC4 Gene

GeneLoc Exon Structure for
IGDCC4
ECgene alternative splicing isoforms for
IGDCC4

Expression for IGDCC4 Gene

mRNA expression in normal human tissues for IGDCC4 Gene

mRNA differential expression in normal tissues according to GTEx for IGDCC4 Gene

This gene is overexpressed in Ovary (x4.3).

Protein differential expression in normal tissues from HIPED for IGDCC4 Gene

This gene is overexpressed in Plasma (26.7), Fetal ovary (21.4), and Fetal testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGDCC4 Gene



SOURCE GeneReport for Unigene cluster for IGDCC4 Gene Hs.458607

genes like me logo Genes that share expression patterns with IGDCC4: view

Protein tissue co-expression partners for IGDCC4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IGDCC4 Gene

Orthologs for IGDCC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGDCC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IGDCC4 35
  • 88.67 (n)
  • 89.28 (a)
IGDCC4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGDCC4 35
  • 89.44 (n)
  • 90.45 (a)
IGDCC4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igdcc4 35
  • 85 (n)
  • 88.45 (a)
Igdcc4 16
Igdcc4 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IGDCC4 35
  • 99.36 (n)
  • 99.28 (a)
IGDCC4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igdcc4 35
  • 85.18 (n)
  • 88.91 (a)
oppossum
(Monodelphis domestica)
Mammalia IGDCC4 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGDCC4 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGDCC4 35
  • 68.32 (n)
  • 68.56 (a)
IGDCC4 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGDCC4 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igdcc4 35
  • 57.43 (n)
  • 51.69 (a)
zebrafish
(Danio rerio)
Actinopterygii igdcc4 35
  • 59.29 (n)
  • 55.19 (a)
igdcc4 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cont 36
  • 13 (a)
OneToMany
Species with no ortholog for IGDCC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGDCC4 Gene

ENSEMBL:
Gene Tree for IGDCC4 (if available)
TreeFam:
Gene Tree for IGDCC4 (if available)

Paralogs for IGDCC4 Gene

Paralogs for IGDCC4 Gene

(1) SIMAP similar genes for IGDCC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGDCC4: view

Variants for IGDCC4 Gene

Sequence variations from dbSNP and Humsavar for IGDCC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs34355056 - 65,411,287(+) TGCAG(A/C/G)CTGCT reference, missense, utr-variant-5-prime
rs12442757 - 65,396,929(+) GCGCG(C/T)TGGCA reference, missense
rs33918653 -, - 65,384,388(+) TCCTG(C/T)AGGCT reference, missense
rs1469778 - 65,390,156(+) ACACC(A/T)GGTGG reference, missense
rs77389 -- 65,403,448(+) ATTTT(A/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGDCC4 Gene

Variant ID Type Subtype PubMed ID
nsv904309 CNV Loss 21882294
dgv2399n71 CNV Loss 21882294
nsv515939 CNV Loss 19592680
esv21441 CNV Loss 19812545

Variation tolerance for IGDCC4 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.09; 96.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IGDCC4 Gene

Disorders for IGDCC4 Gene

Relevant External Links for IGDCC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGDCC4

No disorders were found for IGDCC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGDCC4 Gene

Publications for IGDCC4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 67
  2. Neighbor of Punc E11, a novel oncofetal marker for hepatocellular carcinoma. (PMID: 20658536) Marquardt J.U. … Nierhoff D. (Int. J. Cancer 2011) 3
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. An investigation into the human serum "interactome". (PMID: 15174051) Zhou M. … Conrads T.P. (Electrophoresis 2004) 3

Products for IGDCC4 Gene

Sources for IGDCC4 Gene

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