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Aliases for IGDCC4 Gene

Aliases for IGDCC4 Gene

  • Immunoglobulin Superfamily DCC Subclass Member 4 2 3 5
  • Likely Ortholog Of Mouse Neighbor Of Punc E11 2 3
  • Neighbor Of Punc E11 3 4
  • DDM36 3 4
  • NOPE 3 4
  • Immunoglobulin Superfamily, DCC Subclass, Member 4 2
  • Protein DDM36 4
  • KIAA1628 4
  • HDDM36 4

External Ids for IGDCC4 Gene

Previous GeneCards Identifiers for IGDCC4 Gene

  • GC15M063461
  • GC15M065673
  • GC15M042497

Summaries for IGDCC4 Gene

GeneCards Summary for IGDCC4 Gene

IGDCC4 (Immunoglobulin Superfamily DCC Subclass Member 4) is a Protein Coding gene. An important paralog of this gene is PRTG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGDCC4 Gene

Genomics for IGDCC4 Gene

Regulatory Elements for IGDCC4 Gene

Enhancers for IGDCC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F065400 1.2 Ensembl ENCODE 22.3 +20.4 20431 4.9 KLF17 THRB ZNF2 RAD21 GLIS2 SCRT2 ZNF143 ZNF391 EGR2 ZNF654 IGDCC4 IGDCC3 RNU6-19P HACD3
GH15F065419 1.4 FANTOM5 ENCODE 12.3 +1.6 1587 4.2 HDGF ZNF133 SIN3A GLI4 ZNF48 ZNF2 ZNF121 GLIS2 KLF7 ZNF263 ENSG00000259346 RNU5B-1 RNU5A-1 HNRNPA1P44 ENSG00000239465 IGDCC4 IGDCC3 ENSG00000264937 ZNF609 ENSG00000260773
GH15F065408 1.2 Ensembl ENCODE 10.4 +9.4 9441 11.0 HDGF PKNOX1 SIN3A FEZF1 ZNF2 ETS1 ZNF121 GLIS2 FOS KLF7 ENSG00000264937 IGDCC3 IGDCC4 ZNF609 ENSG00000260773 DPP8
GH15F065376 1 ENCODE 11.3 +45.1 45114 2.5 ZNF133 ARID4B GLI4 DMAP1 ZNF48 ZNF2 GLIS2 ZNF263 SP3 SP5 IGDCC4 ENSG00000260773 RNU5B-1 SLC24A1 IGDCC3 GC15P067945
GH15F065363 0.9 ENCODE 11.3 +57.5 57500 3.4 PKNOX1 SIN3A RAD21 ETS1 ZNF121 ZNF366 ZNF207 RCOR1 ZHX2 GATAD2B IGDCC4 HACD3 RNU5B-1 GC15P067945 IGDCC3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGDCC4 on UCSC Golden Path with GeneCards custom track

Promoters for IGDCC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001453110 772 2201 HDGF ZNF133 SIN3A GLI4 ZNF48 ZNF2 ZNF121 GLIS2 KLF7 ZNF263

Genomic Location for IGDCC4 Gene

65,381,464 bp from pter
65,423,072 bp from pter
41,609 bases
Minus strand

Genomic View for IGDCC4 Gene

Genes around IGDCC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGDCC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGDCC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGDCC4 Gene

Proteins for IGDCC4 Gene

  • Protein details for IGDCC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily DCC subclass member 4
    Protein Accession:
    Secondary Accessions:
    • Q9HCE4

    Protein attributes for IGDCC4 Gene

    1250 amino acids
    Molecular mass:
    134210 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGDCC4 Gene


neXtProt entry for IGDCC4 Gene

Post-translational modifications for IGDCC4 Gene

  • Glycosylation at Asn 90, Asn 102, Asn 157, Asn 252, and Asn 582
  • Modification sites at PhosphoSitePlus

Other Protein References for IGDCC4 Gene

No data available for DME Specific Peptides for IGDCC4 Gene

Domains & Families for IGDCC4 Gene

Protein Domains for IGDCC4 Gene

Suggested Antigen Peptide Sequences for IGDCC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 fibronectin type-III domains.
  • Belongs to the immunoglobulin superfamily. DCC family.
  • Contains 5 fibronectin type-III domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with IGDCC4: view

Function for IGDCC4 Gene

Phenotypes for IGDCC4 Gene

genes like me logo Genes that share phenotypes with IGDCC4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGDCC4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGDCC4 Gene

Localization for IGDCC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGDCC4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGDCC4 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IGDCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGDCC4: view

Pathways & Interactions for IGDCC4 Gene

SuperPathways for IGDCC4 Gene

No Data Available

Interacting Proteins for IGDCC4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: ENSP00000319623 Q8TDY8-IGDC4_HUMAN for IGDCC4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IGDCC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGDCC4 Gene

Transcripts for IGDCC4 Gene

Unigene Clusters for IGDCC4 Gene

Immunoglobulin superfamily, DCC subclass, member 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC4 Gene

No ASD Table

Relevant External Links for IGDCC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGDCC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGDCC4 Gene

mRNA differential expression in normal tissues according to GTEx for IGDCC4 Gene

This gene is overexpressed in Ovary (x4.3).

Protein differential expression in normal tissues from HIPED for IGDCC4 Gene

This gene is overexpressed in Plasma (26.7), Fetal ovary (21.4), and Fetal testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGDCC4 Gene

Protein tissue co-expression partners for IGDCC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGDCC4 Gene:


SOURCE GeneReport for Unigene cluster for IGDCC4 Gene:

genes like me logo Genes that share expression patterns with IGDCC4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IGDCC4 Gene

Orthologs for IGDCC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGDCC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGDCC4 34 35
  • 99.36 (n)
(Canis familiaris)
Mammalia IGDCC4 34 35
  • 89.44 (n)
(Bos Taurus)
Mammalia IGDCC4 34 35
  • 88.67 (n)
(Rattus norvegicus)
Mammalia Igdcc4 34
  • 85.18 (n)
(Mus musculus)
Mammalia Igdcc4 34 16 35
  • 85 (n)
(Monodelphis domestica)
Mammalia IGDCC4 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia IGDCC4 35
  • 63 (a)
(Gallus gallus)
Aves IGDCC4 34 35
  • 68.32 (n)
(Anolis carolinensis)
Reptilia IGDCC4 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia igdcc4 34
  • 57.43 (n)
(Danio rerio)
Actinopterygii igdcc4 34 35
  • 59.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cont 35
  • 13 (a)
Species where no ortholog for IGDCC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGDCC4 Gene

Gene Tree for IGDCC4 (if available)
Gene Tree for IGDCC4 (if available)

Paralogs for IGDCC4 Gene

Paralogs for IGDCC4 Gene

(1) SIMAP similar genes for IGDCC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGDCC4: view

Variants for IGDCC4 Gene

Sequence variations from dbSNP and Humsavar for IGDCC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1010285 -- 65,408,981(-) CAGTG(C/T)GGTGC intron-variant
rs10557918 -- 65,405,567(+) CCCTC(-/TT)ATTGT intron-variant
rs10563998 -- 65,412,945(+) TCTGT(-/AC)ACACA intron-variant
rs11071841 -- 65,389,463(+) AGCAG(A/G)GCAGA intron-variant
rs11071842 -- 65,391,321(+) GGAGT(A/G)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGDCC4 Gene

Variant ID Type Subtype PubMed ID
nsv951976 CNV deletion 24416366
nsv515939 CNV loss 19592680
nsv1036360 CNV gain 25217958
esv21441 CNV loss 19812545

Variation tolerance for IGDCC4 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.09; 96.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGDCC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGDCC4 Gene

Disorders for IGDCC4 Gene

Relevant External Links for IGDCC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGDCC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGDCC4 Gene

Publications for IGDCC4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  2. Neighbor of Punc E11, a novel oncofetal marker for hepatocellular carcinoma. (PMID: 20658536) Marquardt J.U. … Nierhoff D. (Int. J. Cancer 2011) 3 64
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 64
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64

Products for IGDCC4 Gene

Sources for IGDCC4 Gene

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