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Aliases for IGDCC4 Gene

Aliases for IGDCC4 Gene

  • Immunoglobulin Superfamily DCC Subclass Member 4 2 3 5
  • Likely Ortholog Of Mouse Neighbor Of Punc E11 2 3
  • Neighbor Of Punc E11 3 4
  • DDM36 3 4
  • NOPE 3 4
  • Immunoglobulin Superfamily, DCC Subclass, Member 4 2
  • Protein DDM36 4
  • KIAA1628 4
  • HDDM36 4

External Ids for IGDCC4 Gene

Previous GeneCards Identifiers for IGDCC4 Gene

  • GC15M063461
  • GC15M065673
  • GC15M042497

Summaries for IGDCC4 Gene

GeneCards Summary for IGDCC4 Gene

IGDCC4 (Immunoglobulin Superfamily DCC Subclass Member 4) is a Protein Coding gene. An important paralog of this gene is PRTG.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGDCC4 Gene

Genomics for IGDCC4 Gene

Regulatory Elements for IGDCC4 Gene

Enhancers for IGDCC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G065400 1.4 Ensembl ENCODE dbSUPER 22.3 +20.4 20431 4.9 SIN3A ZNF2 GLIS2 ZNF143 REST SMARCA4 ZSCAN16 GLIS1 WT1 SP7 IGDCC4 IGDCC3 RNU6-19P HACD3
GH15G065419 1.6 FANTOM5 ENCODE dbSUPER 12.3 +1.6 1587 4.2 HDGF SIN3A ZNF2 ZBTB7B ZNF263 SP3 REST ZNF592 SMARCA4 ZSCAN16 ENSG00000260773 IGDCC4 IGDCC3 ENSG00000264937 ZNF609 DENND4A INTS14
GH15G065408 1.5 Ensembl ENCODE dbSUPER 10.4 +9.4 9441 11.0 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 ETS1 ZNF121 GLIS2 FOS ZNF609 ENSG00000260773 SLC24A1 ENSG00000264937 IGDCC3 IGDCC4 DPP8
GH15G065376 1 ENCODE 11.3 +45.1 45114 2.5 ZNF133 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 GLIS2 ZNF263 SP3 IGDCC4 ENSG00000260773 RNU5B-1 SLC24A1 IGDCC3 GC15P068436
GH15G065817 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -397.1 -397061 4.7 HDGF PKNOX1 ARNT TCF12 ELK1 GATA2 FOS JUNB NCOA1 REST DENND4A ENSG00000260773 SLC24A1 MTFMT RAB11A ENSG00000238311 CILP IGDCC4 ZWILCH DPP8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGDCC4 on UCSC Golden Path with GeneCards custom track

Promoters for IGDCC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078088 272 801 ZNF133 SIN3A GLI4 ZNF2 ZNF48 ZBTB7B ZNF121 GLIS2 KLF7 ZNF263
ENSR00000277947 1472 401 HDGF INSM2 KLF17 ZNF121 GLIS2 EGR1 KLF7 ZNF391 CREM EGR2

Genomic Location for IGDCC4 Gene

Chromosome:
15
Start:
65,381,464 bp from pter
End:
65,423,072 bp from pter
Size:
41,609 bases
Orientation:
Minus strand

Genomic View for IGDCC4 Gene

Genes around IGDCC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGDCC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGDCC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGDCC4 Gene

Proteins for IGDCC4 Gene

  • Protein details for IGDCC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDY8-IGDC4_HUMAN
    Recommended name:
    Immunoglobulin superfamily DCC subclass member 4
    Protein Accession:
    Q8TDY8
    Secondary Accessions:
    • Q9HCE4

    Protein attributes for IGDCC4 Gene

    Size:
    1250 amino acids
    Molecular mass:
    134210 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGDCC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGDCC4 Gene

Post-translational modifications for IGDCC4 Gene

  • Glycosylation at posLast=9090, posLast=102102, isoforms=157, isoforms=252, and posLast=582582
  • Modification sites at PhosphoSitePlus

Other Protein References for IGDCC4 Gene

No data available for DME Specific Peptides for IGDCC4 Gene

Domains & Families for IGDCC4 Gene

Protein Domains for IGDCC4 Gene

Suggested Antigen Peptide Sequences for IGDCC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDY8

UniProtKB/Swiss-Prot:

IGDC4_HUMAN :
  • Belongs to the immunoglobulin superfamily. DCC family.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with IGDCC4: view

Function for IGDCC4 Gene

Phenotypes for IGDCC4 Gene

genes like me logo Genes that share phenotypes with IGDCC4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGDCC4

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGDCC4 Gene

Localization for IGDCC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGDCC4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGDCC4 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IGDCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGDCC4: view

Pathways & Interactions for IGDCC4 Gene

SuperPathways for IGDCC4 Gene

No Data Available

Interacting Proteins for IGDCC4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000319623%0d%0a9606.ENSP00000173229%0d%0a9606.ENSP00000270235%0d%0a9606.ENSP00000293973%0d%0a9606.ENSP00000376921%0d%0a9606.ENSP00000359085%0d%0a
Selected Interacting proteins: ENSP00000319623 Q8TDY8-IGDC4_HUMAN for IGDCC4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IGDCC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGDCC4 Gene

Drugs & Compounds for IGDCC4 Gene

No Compound Related Data Available

Transcripts for IGDCC4 Gene

Unigene Clusters for IGDCC4 Gene

Immunoglobulin superfamily, DCC subclass, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC4 Gene

No ASD Table

Relevant External Links for IGDCC4 Gene

GeneLoc Exon Structure for
IGDCC4
ECgene alternative splicing isoforms for
IGDCC4

Expression for IGDCC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGDCC4 Gene

mRNA differential expression in normal tissues according to GTEx for IGDCC4 Gene

This gene is overexpressed in Ovary (x4.3).

Protein differential expression in normal tissues from HIPED for IGDCC4 Gene

This gene is overexpressed in Plasma (26.7), Fetal ovary (21.4), and Fetal testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGDCC4 Gene



Protein tissue co-expression partners for IGDCC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGDCC4 Gene:

IGDCC4

SOURCE GeneReport for Unigene cluster for IGDCC4 Gene:

Hs.458607

Evidence on tissue expression from TISSUES for IGDCC4 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with IGDCC4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGDCC4 Gene

Orthologs for IGDCC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGDCC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGDCC4 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia IGDCC4 34 35
  • 89.44 (n)
cow
(Bos Taurus)
Mammalia IGDCC4 34 35
  • 88.67 (n)
rat
(Rattus norvegicus)
Mammalia Igdcc4 34
  • 85.18 (n)
mouse
(Mus musculus)
Mammalia Igdcc4 34 16 35
  • 85 (n)
oppossum
(Monodelphis domestica)
Mammalia IGDCC4 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGDCC4 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGDCC4 34 35
  • 68.32 (n)
lizard
(Anolis carolinensis)
Reptilia IGDCC4 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igdcc4 34
  • 57.43 (n)
zebrafish
(Danio rerio)
Actinopterygii igdcc4 34 35
  • 59.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cont 35
  • 13 (a)
OneToMany
Species where no ortholog for IGDCC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGDCC4 Gene

ENSEMBL:
Gene Tree for IGDCC4 (if available)
TreeFam:
Gene Tree for IGDCC4 (if available)

Paralogs for IGDCC4 Gene

Paralogs for IGDCC4 Gene

(1) SIMAP similar genes for IGDCC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGDCC4: view

Variants for IGDCC4 Gene

Sequence variations from dbSNP and Humsavar for IGDCC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000065496 -- 65,386,091(+) ATAGC(C/G)GTCAG intron-variant
rs1000074587 -- 65,416,105(+) ATTTA(C/T)GAGGC intron-variant
rs1000130719 -- 65,388,237(+) GAAAC(C/T)CCATC intron-variant
rs1000214909 -- 65,383,092(+) GGCAG(A/G)AGGAT utr-variant-3-prime
rs1000257743 -- 65,421,922(+) TTTCT(C/T)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGDCC4 Gene

Variant ID Type Subtype PubMed ID
esv21441 CNV loss 19812545
nsv1036360 CNV gain 25217958
nsv515939 CNV loss 19592680
nsv951976 CNV deletion 24416366

Variation tolerance for IGDCC4 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.09; 96.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGDCC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGDCC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGDCC4 Gene

Disorders for IGDCC4 Gene

Relevant External Links for IGDCC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGDCC4

No disorders were found for IGDCC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGDCC4 Gene

Publications for IGDCC4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  2. Neighbor of Punc E11, a novel oncofetal marker for hepatocellular carcinoma. (PMID: 20658536) Marquardt J.U. … Nierhoff D. (Int. J. Cancer 2011) 3 64
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 64
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64

Products for IGDCC4 Gene

Sources for IGDCC4 Gene

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