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Aliases for IGDCC3 Gene

Aliases for IGDCC3 Gene

  • Immunoglobulin Superfamily DCC Subclass Member 3 2 3
  • Putative Neuronal Cell Adhesion Molecule 2 3 4
  • Immunoglobulin Superfamily, DCC Subclass, Member 3 3 5
  • PUNC 3 4
  • HsT18880 3

External Ids for IGDCC3 Gene

Previous HGNC Symbols for IGDCC3 Gene

  • PUNC

Previous GeneCards Identifiers for IGDCC3 Gene

  • GC15M063406
  • GC15M065619
  • GC15M042443

Summaries for IGDCC3 Gene

GeneCards Summary for IGDCC3 Gene

IGDCC3 (Immunoglobulin Superfamily DCC Subclass Member 3) is a Protein Coding gene. An important paralog of this gene is PRTG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGDCC3 Gene

Genomics for IGDCC3 Gene

Regulatory Elements for IGDCC3 Gene

Promoters for IGDCC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IGDCC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGDCC3 Gene

Chromosome:
15
Start:
65,327,127 bp from pter
End:
65,378,040 bp from pter
Size:
50,914 bases
Orientation:
Minus strand

Genomic View for IGDCC3 Gene

Genes around IGDCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGDCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGDCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGDCC3 Gene

Proteins for IGDCC3 Gene

  • Protein details for IGDCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVU1-IGDC3_HUMAN
    Recommended name:
    Immunoglobulin superfamily DCC subclass member 3
    Protein Accession:
    Q8IVU1
    Secondary Accessions:
    • O95215

    Protein attributes for IGDCC3 Gene

    Size:
    814 amino acids
    Molecular mass:
    86724 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGDCC3 Gene

Proteomics data for IGDCC3 Gene at MOPED

Post-translational modifications for IGDCC3 Gene

  • Glycosylation at Asn 93, Asn 246, Asn 381, Asn 382, Asn 580, Asn 604, and Asn 634
  • Modification sites at PhosphoSitePlus

Other Protein References for IGDCC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGDCC3 Gene

Domains & Families for IGDCC3 Gene

Protein Domains for IGDCC3 Gene

Suggested Antigen Peptide Sequences for IGDCC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVU1

UniProtKB/Swiss-Prot:

IGDC3_HUMAN :
  • Contains 2 fibronectin type-III domains.
  • Belongs to the immunoglobulin superfamily. DCC family.
Domain:
  • Contains 2 fibronectin type-III domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with IGDCC3: view

Function for IGDCC3 Gene

genes like me logo Genes that share phenotypes with IGDCC3: view

Animal Models for IGDCC3 Gene

MGI Knock Outs for IGDCC3:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGDCC3 Gene

Localization for IGDCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGDCC3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGDCC3 Gene COMPARTMENTS Subcellular localization image for IGDCC3 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IGDCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGDCC3: view

Pathways & Interactions for IGDCC3 Gene

SuperPathways for IGDCC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGDCC3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGDCC3 Gene

Drugs & Compounds for IGDCC3 Gene

No Compound Related Data Available

Transcripts for IGDCC3 Gene

Unigene Clusters for IGDCC3 Gene

Immunoglobulin superfamily, DCC subclass, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for IGDCC3 Gene

GeneLoc Exon Structure for
IGDCC3
ECgene alternative splicing isoforms for
IGDCC3

Expression for IGDCC3 Gene

mRNA expression in normal human tissues for IGDCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGDCC3 Gene

This gene is overexpressed in Brain - Cerebellum (x7.1), Brain - Cerebellar Hemisphere (x6.3), and Testis (x4.8).

Protein differential expression in normal tissues from HIPED for IGDCC3 Gene

This gene is overexpressed in Liver, secretome (54.2) and Heart (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGDCC3 Gene



SOURCE GeneReport for Unigene cluster for IGDCC3 Gene Hs.128292

genes like me logo Genes that share expression patterns with IGDCC3: view

Protein tissue co-expression partners for IGDCC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGDCC3 Gene

Orthologs for IGDCC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGDCC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGDCC3 35
  • 99.47 (n)
  • 99.75 (a)
IGDCC3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGDCC3 36
  • 88 (a)
OneToOne
IGDCC3 35
  • 89.15 (n)
  • 92.16 (a)
dog
(Canis familiaris)
Mammalia IGDCC3 35
  • 89.05 (n)
  • 91.23 (a)
IGDCC3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igdcc3 16
Igdcc3 36
  • 87 (a)
OneToOne
Igdcc3 35
  • 87.07 (n)
  • 90.83 (a)
oppossum
(Monodelphis domestica)
Mammalia IGDCC3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGDCC3 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igdcc3 35
  • 86.37 (n)
  • 88.75 (a)
chicken
(Gallus gallus)
Aves IGDCC3 35
  • 70.71 (n)
  • 69.79 (a)
IGDCC3 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGDCC3 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igdcc3 35
  • 63.85 (n)
  • 65.16 (a)
zebrafish
(Danio rerio)
Actinopterygii igdcc3 36
  • 59 (a)
OneToOne
igdcc3 35
  • 64.05 (n)
  • 62.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cont 36
  • 11 (a)
OneToMany
Species with no ortholog for IGDCC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGDCC3 Gene

ENSEMBL:
Gene Tree for IGDCC3 (if available)
TreeFam:
Gene Tree for IGDCC3 (if available)

Paralogs for IGDCC3 Gene

Paralogs for IGDCC3 Gene

(13) SIMAP similar genes for IGDCC3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for IGDCC3 Gene

genes like me logo Genes that share paralogs with IGDCC3: view

Variants for IGDCC3 Gene

Sequence variations from dbSNP and Humsavar for IGDCC3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs12907128 - 65,329,103(+) CAGCA(A/C/T)GGAGA reference, missense
rs650494 -- 65,358,935(+) ATTCT(G/T)GTGCC intron-variant
rs650851 -- 65,347,800(-) GCACA(C/T)GCCAC intron-variant
rs651376 -- 65,359,073(+) CACCT(A/G)CCCCA intron-variant
rs655615 -- 65,354,747(-) TGGCA(A/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGDCC3 Gene

Variant ID Type Subtype PubMed ID
nsv904309 CNV Loss 21882294
nsv457182 CNV Loss 19166990
dgv2398n71 CNV Loss 21882294
nsv457183 CNV Loss 19166990
dgv2399n71 CNV Loss 21882294
esv28479 CNV Gain 19812545

Variation tolerance for IGDCC3 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGDCC3 Gene

HapMap Linkage Disequilibrium report
IGDCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGDCC3 Gene

Disorders for IGDCC3 Gene

Relevant External Links for IGDCC3

Genetic Association Database (GAD)
IGDCC3
Human Genome Epidemiology (HuGE) Navigator
IGDCC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGDCC3

No disorders were found for IGDCC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGDCC3 Gene

Publications for IGDCC3 Gene

  1. Genomic structure and chromosomal localization of the mouse gene Punc. (PMID: 9922388) Salbaum J.M. (Mamm. Genome 1999) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for IGDCC3 Gene

Sources for IGDCC3 Gene

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