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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGDCC3 Gene

protein-coding GIFtS: 49
GCID: GC15M065619

immunoglobulin superfamily, DCC subclass, member 3

(Previous name: putative neuronal cell adhesion molecule )
(Previous symbol: PUNC)

Explore 2 diseases affiliated with
IGDCC3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Immunoglobulin Superfamily, DCC Subclass, Member 3¹ ²
PUNC¹ ² ³ ⁵
Putative Neuronal Cell Adhesion Molecule¹ ² ³
HsT18880¹ ²
Immunoglobulin Superfamily DCC Subclass Member 3²

External Ids:	HGNC: 9700¹	Entrez Gene: 9543²	Ensembl: ENSG00000174498⁷	OMIM: 604184⁵	UniProtKB: Q8IVU1³

Export aliases for IGDCC3 gene to outside databases

Previous GC identifers: GC15M063406 GC15M042443

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGDCC3 gene promoter:
AREB6 STAT1 NRSF form 1 STAT3 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) AP-4 NRSF form 2 POU3F2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGDCC3 promoter sequence

Search SABiosciences Chromatin IP Primers for IGDCC3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGDCC3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.3-q23 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q22.3-q23

IGDCC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGDCC3 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M065619: view genomic region (about GC identifiers)

Start:	65,619,465 bp from pter	End:	65,670,378 bp from pter
Size:	50,914 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IGDC3_HUMAN, Q8IVU1 (See protein sequence)

Recommended Name: Immunoglobulin superfamily DCC subclass member 3 precursor

Size: 814 amino acids; 86724 Da

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: O95215

Explore the universe of human proteins at neXtProt for IGDCC3: NX_Q8IVU1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IVU1

IGDCC3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004875.2

ENSEMBL proteins:

ENSP00000332773 ENSP00000454105 ENSP00000452838

Human Recombinant Protein Products for IGDCC3:

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	Novus Biologicals IGDCC3 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IGDCC3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	IEA	--

IGDCC3 for ontologies About GeneDecksing

IGDCC3 Antibody Products:

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	Uscn Antibodies for IGDCC3
	Search ThermoFisher Antibodies for IGDCC3

Assay Products for IGDCC3:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for IGDCC3
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	Uscn ELISAs and CLIAs for IGDCC3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGDCC3 for domains About GeneDecksing

5 InterPro domains/families:

IPR003598 Ig_sub2

IPR003961 Fibronectin_type3

IPR013098 Ig_I-set

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q8IVU1

ProtoNet protein and cluster: Q8IVU1

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: IGDC3_HUMAN, Q8IVU1

Similarity: Belongs to the immunoglobulin superfamily. DCC family

Similarity: Contains 2 fibronectin type-III domains

Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
2 GenomeRNAi human phenotypes for IGDCC3:

Decreased viability of wild-ty

Increased HPV18 LCR reporter a

1 MGI mutant phenotype (inferred from 3 alleles) (MGI details for Igdcc3):

behavior/neurological

IGDCC3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IGDCC3

miRNA Products:		OriGene 3'-UTR Clone: IGDCC3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGDCC3
		8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate IGDCC3 (see all 73):
		hsa-miR-520e hsa-miR-520f hsa-miR-631 hsa-miR-761 hsa-miR-520b hsa-miR-4324 hsa-miR-1298 hsa-miR-130a*

		SwitchGear 3'UTR luciferase reporter plasmid: IGDCC3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGDCC3 OriGene shRNA RFP: IGDCC3 OriGene siRNA: IGDCC3
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		Sirion Biotech Custom design and validation of potent shRNA sequences against IGDCC3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IGDCC3
			Sirion Biotech Customized adenovirus for overexpression of IGDCC3 Sirion Biotech Customized adenovirus for potent knockdown of IGDCC3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: IGDCC3 (NM_004884)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGDCC3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGDCC3
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		Sirion Biotech Customized stable knockdown cell line services for IGDCC3 Sirion Biotech Customized inducible knockdown cell line services for IGDCC3 Sirion Biotech Customized stable overexpressing cell line services for IGDCC3 Sirion Biotech Customized inducible overexpressing cell line services for IGDCC3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGDCC3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IGDCC3

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for IGDCC3 (Q8IVU1³ ENSP00000332773⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FTL	P02792³, ENSP00000366525⁴	I2D: score=1 STRING: ENSP00000366525
TAPBPL	ENSP00000266556⁴	STRING: ENSP00000266556

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0050885	neuromuscular process controlling balance	IEA	--

IGDCC3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGDCC3
Search CenterWatch for drugs/clinical trials and news about IGDCC3 / IGDC3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IGDCC3 gene:

NM_004884.3

Unigene Cluster for IGDCC3:

Immunoglobulin superfamily, DCC subclass, member 3

Hs.128292 [show with all ESTs]

Unigene Representative Sequence: NM_004884

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000327987(uc002aos.2 uc002aor.1) ENST00000558354 ENST00000559231

ENST00000559058 ENST00000559947

miRNA Products:		OriGene 3'-UTR Clone: IGDCC3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGDCC3
		8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate IGDCC3 (see all 73):
		hsa-miR-520e hsa-miR-520f hsa-miR-631 hsa-miR-761 hsa-miR-520b hsa-miR-4324 hsa-miR-1298 hsa-miR-130a*

		SwitchGear 3'UTR luciferase reporter plasmid: IGDCC3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGDCC3 OriGene shRNA RFP: IGDCC3 OriGene siRNA: IGDCC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGDCC3
		Sirion Biotech Custom design and validation of potent shRNA sequences against IGDCC3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGDCC3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGDCC3 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IGDCC3 (NM_004884)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGDCC3

Additional cDNA sequence:

AF063936.1 AK095529.1 BC042054.1 BC067107.1

7 DOTS entries:

DT.97788800 DT.100019445 DT.306344 DT.308680 DT.102827139 DT.40266764 DT.97858000

24/53 AceView cDNA sequences (see all 53):

BQ650842 BF515654 BE252669 CR623830 BX331927 BQ644258 AW235450 BQ646105

BF312550 D80658 BC042054 BV194295 AW204060 D80574 AA973158 AA953395

BX093294 BC067107 BX389424 AK095529 AI740721 AF063936 BG329402 BM726906

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC3 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19a	·	19b
SP1:							-		-		-										-
SP2:											-										-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for IGDCC3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGDCC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTGGAACT

About this image

IGDCC3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Kidney

Diencephalic Ventricular Zone

Neural Tube

Neural Tube

Neural Tube

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IGDCC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGDCC3

SOURCE GeneReport for Unigene cluster: Hs.128292

SABiosciences Custom PCR Arrays for IGDCC3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGDCC3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGDCC3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGDCC3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for IGDCC3 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IGDCC3¹	immunoglobulin superfamily, DCC subclass, member 3	69.62(n) 67.93(a)		415535 XM_413904.3 XP_413904.2
lizard (Anolis carolinensis)	Reptilia	IGDCC3⁶	--	77(a)	1 ↔ 1	1(194518537-194551085)
zebrafish (Danio rerio)	Actinopterygii	igdcc3¹	immunoglobulin superfamily, DCC subclass, member 3	65.67(n) 65.37(a)		555947 XM_003198969.1 XP_003199017.1
honey bee (Apis mellifera)	Insecta	--	--	14(a)	1 → many	Group4.19(39194-45176)

ENSEMBL Gene Tree for IGDCC3 (if available)
TreeFam Gene Tree for IGDCC3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGDCC3 gene

CDON² ROBO2² NEO1² ROBO1² ROBO4² IGDCC4² BOC² DCC²

PRTG² ROBO3²

15 SIMAP similar genes for IGDCC3 using alignment to 3 protein entries: IGDC3_HUMAN (see all proteins):

PRTG MUSK DCC PTPRS HMCN2 PXDN

HSPG2 PTPRD ROBO3 SDK1 IGLV3-16 IGLV3-25

V2-7 PAPLN PXDNL

IGDCC3 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for IGDCC3
PGOHUM00000262135

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181755707^1,2		--	65618972(+)	`GACCAC/GCCAGG`	1	--	ds500¹		0	--	--	--	--
rs184749052^1,2		--	65619006(+)	`TCACCA/GCTTTG`	1	--	ds500¹		0	--	--	--	--
rs12905133^1,2	C,F,H	--	65619042(+)	`GAGATT/CGGAAG`	1	--	ds500¹		23		NS EA NA WA CSA	2345
rs148343522^1,2		--	65619235(+)	`GGCAAC/GAGAGT`	1	--	ds500¹		0	--	--	--	--
rs141522324^1,2		--	65619289(+)	`ACTAGC/TATATC`	1	--	ds500¹		0	--	--	--	--
rs11071839^1,2	C,F,A,H	--	65619427(+)	`GCCCCT/ACCCCC`	1	--	ds500¹		12		NA WA CSA EA	379
rs11856970^1,2	C,F,H	--	65619582(+)	`GGGAGA/TGGGAG`	1	--	ut3¹		1		NA	6
rs189671228^1,2		--	65619605(+)	`AGCTGC/TTTTGG`	1	--	ut3¹		0	--	--	--	--
rs56835863^1,2		--	65619702(+)	`AAGTCC/AACGCG`	1	--	ut3¹		1		WA	118
rs639812^1,2	C,F,O,A,H	--	65619797(-)	`CCCAAC/TCCTCT`	1	--	ut3¹		27		EA NA MN NS WA CSA	2342

HapMap Linkage Disequilibrium report for IGDCC3 (65619465 - 65670378 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IGDCC3
1 CNV: 72268

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGDCC3

DNA2.0 Custom Variant and Variant Library Synthesis for IGDCC3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGDCC3 for disorders           About GeneDecksing

OMIM gene information: 604184    OMIM disorders: --

2 diseases for IGDCC3:    About MalaCards

bardet-biedl syndrome neuronitis

Human Genome Epidemiology (HuGE) Navigator: IGDCC3 (1 document)

Export disorders for IGDCC3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGDCC3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGDCC3)

Utopia: connect your pdf to the dynamic
world of online information

Genomic structure and chromosomal localization of the mouse gene Punc. (PubMed id 9922388)^{1, 2, 3} Salbaum J.M. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Protein-protein interaction panel using mouse full-length cDNAs. (PubMed id 11591653)¹ Suzuki H....Hayashizaki Y. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9543	HGNC: 9700	AceView: PUNC	Ensembl:ENSG00000174498	euGenes: HUgn9543
ECgene: IGDCC3	H-InvDB: IGDCC3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGDCC3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IGDCC3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IGDCC3 gene:
Search GeneIP for patents involving IGDCC3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	EMD Millipore Custom Antibody & Bulk Services
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	Browse OriGene Antibodies		OriGene shRNA RFP for IGDCC3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGDCC3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGDCC3
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for IGDCC3		OriGene 3'-UTR Clone for IGDCC3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGDCC3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGDCC3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for IGDCC3		OriGene Custom Protein Services for IGDCC3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGDCC3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGDCC3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGDCC3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGDCC3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGDCC3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGDCC3

	GenScript Custom Purified and Recombinant Proteins Services for IGDCC3		GenScript cDNA clones with any tag delivered in your preferred vector for IGDCC3
	GenScript Custom Assay Services for IGDCC3		GenScript Custom Superior Antibodies Services for IGDCC3
	GenScript Custom overexpressing Cell Line Services for IGDCC3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in IGDCC3 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	IGDCC3 antibodies
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	Search for Antibodies for IGDCC3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for IGDCC3
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Browse ProSpec Recombinant Proteins

IGDCC3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for IGDCC3

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGDCC3

	SwitchGear 3'UTR luciferase reporter plasmids for IGDCC3
	SwitchGear Promoter luciferase reporter plasmids for IGDCC3

Search ThermoFisher Antibodies for IGDCC3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGDCC3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IGDCC3

Sirion Biotech Customized:

	stable knockdown cell line services for IGDCC3
	inducible knockdown cell line services for IGDCC3
	design and validation of potent shRNA sequences against IGDCC3
	adenovirus for potent knockdown of IGDCC3
	adenovirus for overexpression of IGDCC3
	stable overexpressing cell line services for IGDCC3
	inducible overexpressing cell line services for IGDCC3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IGDCC3 gene at Home site.

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IGDCC3 Gene

immunoglobulin superfamily, DCC subclass, member 3

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IGDCC3 Gene

immunoglobulin superfamily, DCC subclass, member 3

Aliasesfor IGDCC3 gene

Summariesfor IGDCC3 gene

Genomic Viewsfor IGDCC3 gene

Proteinsfor IGDCC3 gene

Protein Domains /Familiesfor IGDCC3 gene

Functionfor IGDCC3 gene

Pathways & Interactionsfor IGDCC3 gene

Drugs & Compoundsfor IGDCC3 gene

Transcriptsfor IGDCC3 gene

Expression for IGDCC3 gene

Orthologsfor IGDCC3 gene

Paralogsfor IGDCC3 gene

Genomic Variantsfor IGDCC3 gene

Disorders / Diseasesfor IGDCC3 gene

Publicationsfor IGDCC3 gene

External Searches for IGDCC3 gene

Genome Databases showing IGDCC3 gene

Other Databases showing IGDCC3 gene

Specialized Databases showing IGDCC3 gene

Intellectual Propertyfor IGDCC3 gene

Productsfor IGDCC3 gene

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Aliases
for IGDCC3 gene

Summaries
for IGDCC3 gene

Genomic Views
for IGDCC3 gene

Proteins
for IGDCC3 gene

Protein Domains /
Families
for IGDCC3 gene

Function
for IGDCC3 gene

Pathways & Interactions
for IGDCC3 gene

Drugs & Compounds
for IGDCC3 gene

Transcripts
for IGDCC3 gene

Expression
for IGDCC3 gene

Orthologs
for IGDCC3 gene

Paralogs
for IGDCC3 gene

Genomic Variants
for IGDCC3 gene

Disorders / Diseases
for IGDCC3 gene

Publications
for IGDCC3 gene

Intellectual Property
for IGDCC3 gene

Products
for IGDCC3 gene