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Aliases for IGDCC3 Gene

Aliases for IGDCC3 Gene

  • Immunoglobulin Superfamily, DCC Subclass, Member 3 2 3
  • Putative Neuronal Cell Adhesion Molecule 2 3 4
  • PUNC 3 4 6
  • Immunoglobulin Superfamily DCC Subclass Member 3 3
  • HsT18880 3

External Ids for IGDCC3 Gene

Previous HGNC Symbols for IGDCC3 Gene

  • PUNC

Previous GeneCards Identifiers for IGDCC3 Gene

  • GC15M063406
  • GC15M065619
  • GC15M042443

Summaries for IGDCC3 Gene

GeneCards Summary for IGDCC3 Gene

IGDCC3 (Immunoglobulin Superfamily, DCC Subclass, Member 3) is a Protein Coding gene. An important paralog of this gene is PRTG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGDCC3 Gene

Genomics for IGDCC3 Gene

Regulatory Elements for IGDCC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IGDCC3 Gene

Start:
65,327,127 bp from pter
End:
65,378,040 bp from pter
Size:
50,914 bases
Orientation:
Minus strand

Genomic View for IGDCC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGDCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGDCC3 Gene

Proteins for IGDCC3 Gene

  • Protein details for IGDCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVU1-IGDC3_HUMAN
    Recommended name:
    Immunoglobulin superfamily DCC subclass member 3
    Protein Accession:
    Q8IVU1
    Secondary Accessions:
    • O95215

    Protein attributes for IGDCC3 Gene

    Size:
    814 amino acids
    Molecular mass:
    86724 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGDCC3 Gene

Proteomics data for IGDCC3 Gene at MOPED

Post-translational modifications for IGDCC3 Gene

  • Glycosylation at Asn93, Asn246, Asn381, Asn382, Asn580, Asn604, and Asn634
  • Modification sites at PhosphoSitePlus

Other Protein References for IGDCC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGDCC3 Gene

Domains for IGDCC3 Gene

Gene Families for IGDCC3 Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Protein Domains for IGDCC3 Gene

Suggested Antigen Peptide Sequences for IGDCC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVU1

UniProtKB/Swiss-Prot:

IGDC3_HUMAN :
  • Q8IVU1
Domain:
  • Contains 2 fibronectin type-III domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with IGDCC3: view

Function for IGDCC3 Gene

Gene Ontology (GO) - Molecular Function for IGDCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGDCC3: view
genes like me logo Genes that share phenotypes with IGDCC3: view

Animal Model Products

CRISPR Products

miRNA for IGDCC3 Gene

miRTarBase miRNAs that target IGDCC3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGDCC3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGDCC3 Gene

Localization for IGDCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGDCC3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGDCC3 Gene COMPARTMENTS Subcellular localization image for IGDCC3 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IGDCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with IGDCC3: view

Pathways for IGDCC3 Gene

SuperPathways for IGDCC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGDCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050885 neuromuscular process controlling balance IEA --
genes like me logo Genes that share ontologies with IGDCC3: view

No data available for Pathways by source for IGDCC3 Gene

Transcripts for IGDCC3 Gene

Unigene Clusters for IGDCC3 Gene

Immunoglobulin superfamily, DCC subclass, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGDCC3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for IGDCC3 Gene

GeneLoc Exon Structure for
IGDCC3
ECgene alternative splicing isoforms for
IGDCC3

Expression for IGDCC3 Gene

mRNA expression in normal human tissues for IGDCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGDCC3 Gene

This gene is overexpressed in Brain - Cerebellum (7.1), Brain - Cerebellar Hemisphere (6.3), and Testis (4.8).

Protein differential expression in normal tissues for IGDCC3 Gene

This gene is overexpressed in Liver, secretome (54.2) and Heart (14.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IGDCC3 Gene

SOURCE GeneReport for Unigene cluster for IGDCC3 Gene Hs.128292

genes like me logo Genes that share expressions with IGDCC3: view

Expression partners for IGDCC3 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGDCC3 Gene

Orthologs for IGDCC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGDCC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IGDCC3 35
  • 89.15 (n)
  • 92.16 (a)
IGDCC3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGDCC3 35
  • 89.05 (n)
  • 91.23 (a)
IGDCC3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igdcc3 35
  • 87.07 (n)
  • 90.83 (a)
Igdcc3 16
Igdcc3 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IGDCC3 35
  • 99.47 (n)
  • 99.75 (a)
IGDCC3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igdcc3 35
  • 86.37 (n)
  • 88.75 (a)
oppossum
(Monodelphis domestica)
Mammalia IGDCC3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGDCC3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGDCC3 35
  • 70.71 (n)
  • 69.79 (a)
IGDCC3 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGDCC3 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igdcc3 35
  • 63.85 (n)
  • 65.16 (a)
zebrafish
(Danio rerio)
Actinopterygii igdcc3 35
  • 64.05 (n)
  • 62.07 (a)
igdcc3 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cont 36
  • 11 (a)
OneToMany
Species with no ortholog for IGDCC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGDCC3 Gene

ENSEMBL:
Gene Tree for IGDCC3 (if available)
TreeFam:
Gene Tree for IGDCC3 (if available)

Paralogs for IGDCC3 Gene

Selected SIMAP similar genes for IGDCC3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for IGDCC3 Gene

genes like me logo Genes that share paralogs with IGDCC3: view

Variants for IGDCC3 Gene

Sequence variations from dbSNP and Humsavar for IGDCC3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs471954 -- 65,371,472(-) ACCAC(A/T)CCCAT intron-variant
rs475535 -- 65,340,376(-) TCACA(C/G)ACCGG intron-variant
rs476245 -- 65,361,577(-) GGGAA(C/T)TCGCC intron-variant
rs492879 -- 65,335,632(-) AGATT(A/G)TAGGC intron-variant
rs503837 -- 65,354,971(+) CGGTG(C/T)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGDCC3 Gene

Variant ID Type Subtype PubMed ID
nsv904309 CNV Loss 21882294
nsv457182 CNV Loss 19166990
dgv2398n71 CNV Loss 21882294
nsv457183 CNV Loss 19166990
dgv2399n71 CNV Loss 21882294
esv28479 CNV Gain 19812545

Relevant External Links for IGDCC3 Gene

HapMap Linkage Disequilibrium report
IGDCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGDCC3 Gene

Disorders for IGDCC3 Gene

Relevant External Links for IGDCC3

Genetic Association Database (GAD)
IGDCC3
Human Genome Epidemiology (HuGE) Navigator
IGDCC3

No disorders were found for IGDCC3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for IGDCC3 Gene

Publications for IGDCC3 Gene

  1. Genomic structure and chromosomal localization of the mouse gene Punc. (PMID: 9922388) Salbaum J.M. (Mamm. Genome 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4
  5. Protein-protein interaction panel using mouse full-length cDNAs. (PMID: 11591653) Suzuki H. … Hayashizaki Y. (Genome Res. 2001) 3

Products for IGDCC3 Gene

Sources for IGDCC3 Gene

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