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Aliases for IGDCC3 Gene

Aliases for IGDCC3 Gene

  • Immunoglobulin Superfamily DCC Subclass Member 3 2 3 5
  • Putative Neuronal Cell Adhesion Molecule 2 3 4
  • PUNC 3 4
  • HsT18880 3

External Ids for IGDCC3 Gene

Previous HGNC Symbols for IGDCC3 Gene

  • PUNC

Previous GeneCards Identifiers for IGDCC3 Gene

  • GC15M063406
  • GC15M065619
  • GC15M042443

Summaries for IGDCC3 Gene

GeneCards Summary for IGDCC3 Gene

IGDCC3 (Immunoglobulin Superfamily DCC Subclass Member 3) is a Protein Coding gene. An important paralog of this gene is PRTG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGDCC3 Gene

Genomics for IGDCC3 Gene

Regulatory Elements for IGDCC3 Gene

Enhancers for IGDCC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F065318 1.5 Ensembl ENCODE 11.9 +59.0 58996 0.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF609 TRIP4 ENSG00000264937 ENSG00000259635 MTFMT SLC24A1 CILP RNU5B-1 ENSG00000259346 RNU5A-1
GH15F065322 0.8 ENCODE 21.9 +54.8 54777 1.1 BCOR ZNF146 SAP130 SIN3A RAD21 ZIC2 ZNF121 ZFHX2 ZNF316 GLIS2 IGDCC3 GC15M065328 GC15M065329 GC15M065309
GH15F065419 1.4 FANTOM5 ENCODE 12.2 -43.4 -43446 4.2 HDGF ZNF133 SIN3A GLI4 ZNF48 ZNF2 ZNF121 GLIS2 KLF7 ZNF263 ENSG00000259346 RNU5B-1 RNU5A-1 HNRNPA1P44 ENSG00000239465 IGDCC4 IGDCC3 ENSG00000264937 ZNF609 ENSG00000260773
GH15F065400 1.2 Ensembl ENCODE 11.9 -24.6 -24602 4.9 KLF17 THRB ZNF2 RAD21 GLIS2 SCRT2 ZNF143 ZNF391 EGR2 ZNF654 IGDCC4 IGDCC3 RNU6-19P HACD3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGDCC3 on UCSC Golden Path with GeneCards custom track

Promoters for IGDCC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000409773 240 1601 ZNF133 ARID4B FEZF1 DMAP1 ZNF48 ZNF2 GLIS2 ZNF263 SP3 SP5
ENSR00001796024 1340 201 MAZ ZNF341 ZNF524 ZBTB26 ZBTB20 EZH2

Genomic Location for IGDCC3 Gene

65,327,127 bp from pter
65,378,040 bp from pter
50,914 bases
Minus strand

Genomic View for IGDCC3 Gene

Genes around IGDCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGDCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGDCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGDCC3 Gene

Proteins for IGDCC3 Gene

  • Protein details for IGDCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily DCC subclass member 3
    Protein Accession:
    Secondary Accessions:
    • O95215

    Protein attributes for IGDCC3 Gene

    814 amino acids
    Molecular mass:
    86724 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGDCC3 Gene

Post-translational modifications for IGDCC3 Gene

  • Glycosylation at Asn 93, Asn 246, Asn 381, Asn 382, Asn 580, Asn 604, and Asn 634
  • Modification sites at PhosphoSitePlus

Other Protein References for IGDCC3 Gene

No data available for DME Specific Peptides for IGDCC3 Gene

Domains & Families for IGDCC3 Gene

Suggested Antigen Peptide Sequences for IGDCC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 fibronectin type-III domains.
  • Belongs to the immunoglobulin superfamily. DCC family.
  • Contains 2 fibronectin type-III domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with IGDCC3: view

Function for IGDCC3 Gene

genes like me logo Genes that share phenotypes with IGDCC3: view

Animal Models for IGDCC3 Gene

MGI Knock Outs for IGDCC3:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGDCC3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGDCC3 Gene

Localization for IGDCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGDCC3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGDCC3 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IGDCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGDCC3: view

Pathways & Interactions for IGDCC3 Gene

SuperPathways for IGDCC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGDCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050885 neuromuscular process controlling balance IEA --
genes like me logo Genes that share ontologies with IGDCC3: view

No data available for Pathways by source and SIGNOR curated interactions for IGDCC3 Gene

Transcripts for IGDCC3 Gene

Unigene Clusters for IGDCC3 Gene

Immunoglobulin superfamily, DCC subclass, member 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - -
SP2: - -

Relevant External Links for IGDCC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGDCC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGDCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGDCC3 Gene

This gene is overexpressed in Brain - Cerebellum (x7.1), Brain - Cerebellar Hemisphere (x6.3), and Testis (x4.8).

Protein differential expression in normal tissues from HIPED for IGDCC3 Gene

This gene is overexpressed in Liver, secretome (54.2) and Heart (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGDCC3 Gene

Protein tissue co-expression partners for IGDCC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGDCC3 Gene:


SOURCE GeneReport for Unigene cluster for IGDCC3 Gene:

genes like me logo Genes that share expression patterns with IGDCC3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IGDCC3 Gene

Orthologs for IGDCC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGDCC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGDCC3 34 35
  • 99.47 (n)
(Bos Taurus)
Mammalia IGDCC3 34 35
  • 89.15 (n)
(Canis familiaris)
Mammalia IGDCC3 34 35
  • 89.05 (n)
(Mus musculus)
Mammalia Igdcc3 34 16 35
  • 87.07 (n)
(Rattus norvegicus)
Mammalia Igdcc3 34
  • 86.37 (n)
(Monodelphis domestica)
Mammalia IGDCC3 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia IGDCC3 35
  • 76 (a)
(Gallus gallus)
Aves IGDCC3 34 35
  • 70.71 (n)
(Anolis carolinensis)
Reptilia IGDCC3 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia igdcc3 34
  • 63.85 (n)
(Danio rerio)
Actinopterygii igdcc3 34 35
  • 64.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cont 35
  • 11 (a)
Species where no ortholog for IGDCC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGDCC3 Gene

Gene Tree for IGDCC3 (if available)
Gene Tree for IGDCC3 (if available)

Paralogs for IGDCC3 Gene

Paralogs for IGDCC3 Gene

(13) SIMAP similar genes for IGDCC3 Gene using alignment to 3 proteins: Pseudogenes for IGDCC3 Gene

genes like me logo Genes that share paralogs with IGDCC3: view

Variants for IGDCC3 Gene

Sequence variations from dbSNP and Humsavar for IGDCC3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10553352 -- 65,370,515(+) aaaaa(A/T)atata intron-variant
rs10566089 -- 65,370,519(+) AAATA(-/T)ATATA intron-variant
rs10609381 -- 65,367,347(+) GTCTC(-/A)AAAAA intron-variant
rs10642831 -- 65,345,611(+) CGCAC(-/AAAAATA)AAAAA intron-variant
rs10642942 -- 65,370,591(+) TGTAT(-/GTAT)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGDCC3 Gene

Variant ID Type Subtype PubMed ID
esv28479 CNV gain 19812545
esv3636755 CNV loss 21293372
nsv1036360 CNV gain 25217958
nsv457182 CNV loss 19166990
nsv457183 CNV loss 19166990
nsv569705 CNV loss 21841781
nsv569706 CNV loss 21841781
nsv569707 CNV loss 21841781
nsv951975 CNV deletion 24416366

Variation tolerance for IGDCC3 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGDCC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGDCC3 Gene

Disorders for IGDCC3 Gene

Relevant External Links for IGDCC3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGDCC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGDCC3 Gene

Publications for IGDCC3 Gene

  1. Genomic structure and chromosomal localization of the mouse gene Punc. (PMID: 9922388) Salbaum J.M. (Mamm. Genome 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for IGDCC3 Gene

Sources for IGDCC3 Gene

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