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Aliases for IGBP1 Gene

Aliases for IGBP1 Gene

  • Immunoglobulin (CD79A) Binding Protein 1 2 3
  • Protein Phosphatase 2/4/6 Regulatory Subunit 3 4
  • B-Cell Signal Transduction Molecule Alpha 4 3 4
  • Renal Carcinoma Antigen NY-REN-16 3 4
  • CD79a-Binding Protein 1 3 4
  • Protein Alpha-4 3 4
  • IBP1 3 4
  • BA351K23.1 (Immunoglobulin Binding Protein 1 (CD79A) ) 3
  • Protein Phosphatase 2A, Regulatory Subunit Alpha-4 3
  • B Cell Signal Transduction Molecule Alpha 4 3
  • Immunoglobulin-Binding Protein 1 3
  • Alpha 4 2
  • ALPHA-4 3

External Ids for IGBP1 Gene

Previous HGNC Symbols for IGBP1 Gene

  • IBP1

Previous GeneCards Identifiers for IGBP1 Gene

  • GC0XP065531
  • GC0XP066830
  • GC0XP067586
  • GC0XP068220
  • GC0XP069136
  • GC0XP069270
  • GC0XP069353
  • GC0XP063174

Summaries for IGBP1 Gene

Entrez Gene Summary for IGBP1 Gene

  • The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGBP1 Gene

IGBP1 (Immunoglobulin (CD79A) Binding Protein 1) is a Protein Coding gene. Diseases associated with IGBP1 include corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia and agenesis of the corpus callosum - intellectual disability - coloboma - micrognathia. Among its related pathways are Translation Insulin regulation of translation and Phosphatases. GO annotations related to this gene include protein phosphatase type 2A regulator activity and mitogen-activated protein kinase kinase binding.

UniProtKB/Swiss-Prot for IGBP1 Gene

  • Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.

Gene Wiki entry for IGBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGBP1 Gene

Genomics for IGBP1 Gene

Regulatory Elements for IGBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IGBP1 Gene

Start:
70,133,449 bp from pter
End:
70,166,324 bp from pter
Size:
32,876 bases
Orientation:
Plus strand

Genomic View for IGBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGBP1 Gene

Proteins for IGBP1 Gene

  • Protein details for IGBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78318-IGBP1_HUMAN
    Recommended name:
    Immunoglobulin-binding protein 1
    Protein Accession:
    P78318
    Secondary Accessions:
    • Q8TAB2

    Protein attributes for IGBP1 Gene

    Size:
    339 amino acids
    Molecular mass:
    39222 Da
    Quaternary structure:
    • Interacts with partially folded PPP2CA, but not with the fully active protein. Interacts with PPP2CB, and with PP4 and PP6. Interacts with MID1 and MID2. Interacts with ubiquitin.

    Three dimensional structures from OCA and Proteopedia for IGBP1 Gene

neXtProt entry for IGBP1 Gene

Proteomics data for IGBP1 Gene at MOPED

Post-translational modifications for IGBP1 Gene

  • Monoubiquitination by MID1 triggers calpain-mediated cleavage and switches IGBP1 activity from protective to destructive.
  • Phosphorylated.
  • Ubiquitination at Lys44, Lys91, Lys241, and Lys253
  • Modification sites at PhosphoSitePlus

Other Protein References for IGBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IGBP1 (IGBP1)

No data available for DME Specific Peptides for IGBP1 Gene

Domains for IGBP1 Gene

Protein Domains for IGBP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IGBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78318

UniProtKB/Swiss-Prot:

IGBP1_HUMAN :
  • P78318
Domain:
  • The UIM domain is required for protective effect on PP2A.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
Family:
  • Belongs to the IGBP1/TAP42 family.
genes like me logo Genes that share domains with IGBP1: view

No data available for Gene Families for IGBP1 Gene

Function for IGBP1 Gene

Molecular function for IGBP1 Gene

GENATLAS Biochemistry: B cell signal transduction molecule alpha 4,45kDa,expressed preferentially in heart,skeletal muscle and pancreas,similar to yeast TAP42 protein
UniProtKB/Swiss-Prot Function: Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.

Gene Ontology (GO) - Molecular Function for IGBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16085932
GO:0008601 protein phosphatase type 2A regulator activity IDA 9647778
GO:0019904 protein domain specific binding IEA --
GO:0031434 mitogen-activated protein kinase kinase binding IEA --
GO:0051721 protein phosphatase 2A binding IBA --
genes like me logo Genes that share ontologies with IGBP1: view
genes like me logo Genes that share phenotypes with IGBP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGBP1 Gene

Localization for IGBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGBP1 Gene COMPARTMENTS Subcellular localization image for IGBP1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IGBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 9647778
GO:0005829 cytosol IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with IGBP1: view

Pathways for IGBP1 Gene

genes like me logo Genes that share pathways with IGBP1: view

Pathways by source for IGBP1 Gene

1 Cell Signaling Technology pathway for IGBP1 Gene
1 GeneGo (Thomson Reuters) pathway for IGBP1 Gene

Gene Ontology (GO) - Biological Process for IGBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 17438131
GO:0007165 signal transduction NAS 9647778
GO:0009966 regulation of signal transduction --
GO:0032873 negative regulation of stress-activated MAPK cascade IMP 17438131
GO:0034047 regulation of protein phosphatase type 2A activity IDA 9647778
genes like me logo Genes that share ontologies with IGBP1: view

Transcripts for IGBP1 Gene

mRNA/cDNA for IGBP1 Gene

Unigene Clusters for IGBP1 Gene

Immunoglobulin (CD79A) binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGBP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGBP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1:
SP2:
SP3: - - - -
SP4: -
SP5: -
SP6: -

Relevant External Links for IGBP1 Gene

GeneLoc Exon Structure for
IGBP1
ECgene alternative splicing isoforms for
IGBP1

Expression for IGBP1 Gene

mRNA expression in normal human tissues for IGBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGBP1 Gene

SOURCE GeneReport for Unigene cluster for IGBP1 Gene Hs.496267

mRNA Expression by UniProt/SwissProt for IGBP1 Gene

P78318-IGBP1_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas
genes like me logo Genes that share expressions with IGBP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for IGBP1 Gene

Orthologs for IGBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IGBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGBP1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGBP1 35
  • 87.9 (n)
  • 83.93 (a)
IGBP1 36
  • 82 (a)
OneToMany
IGBP1 36
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia IGBP1 35
  • 89.71 (n)
  • 84.57 (a)
IGBP1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igbp1 35
  • 86.69 (n)
  • 80.47 (a)
Igbp1 16
Igbp1 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGBP1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGBP1 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igbp1 35
  • 86.69 (n)
  • 81.36 (a)
chicken
(Gallus gallus)
Aves IGBP1 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGBP1 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igbp1 35
  • 60 (n)
  • 58.21 (a)
Str.1809 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10166 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17830 35
igbp1 35
  • 59.34 (n)
  • 56.97 (a)
igbp1 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008797 35
  • 46.54 (n)
  • 36.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tap42 35
  • 47.35 (n)
  • 34.58 (a)
Tap42 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ppfr-4 35
  • 45.1 (n)
  • 33.66 (a)
ppfr-4 36
  • 30 (a)
OneToOne
Y71H2B.3 37
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAP42 36
  • 21 (a)
OneToOne
TAP42 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for IGBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IGBP1 Gene

ENSEMBL:
Gene Tree for IGBP1 (if available)
TreeFam:
Gene Tree for IGBP1 (if available)

Paralogs for IGBP1 Gene

genes like me logo Genes that share paralogs with IGBP1: view

No data available for Paralogs for IGBP1 Gene

Variants for IGBP1 Gene

Sequence variations from dbSNP and Humsavar for IGBP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1773 -- 70,137,595(-) TATTC(C/G)TCATG intron-variant
rs508906 -- 70,149,158(+) gggag(A/G)gggag intron-variant
rs526053 -- 70,136,784(+) ggctc(A/G)ctgca intron-variant
rs526350 -- 70,149,860(+) GTGGC(A/G)GGAGT intron-variant
rs595828 -- 70,131,682(+) agcct(C/G)ggtgg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IGBP1 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354

Relevant External Links for IGBP1 Gene

HapMap Linkage Disequilibrium report
IGBP1
Human Gene Mutation Database (HGMD)
IGBP1
Locus Specific Mutation Databases (LSDB)
IGBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGBP1 Gene

Disorders for IGBP1 Gene

(1) OMIM Diseases for IGBP1 Gene (300139)

UniProtKB/Swiss-Prot

IGBP1_HUMAN
  • Mental retardation, X-linked, syndromic, 28 (MRXS28) [MIM:300472]: A mental retardation syndrome characterized by agenesis of the corpus callosum, coloboma of the iris and optic nerve, severe retrognathia, and intellectual deficit. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:14556245}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for IGBP1 Gene

Relevant External Links for IGBP1

Human Genome Epidemiology (HuGE) Navigator
IGBP1
genes like me logo Genes that share disorders with IGBP1: view

Publications for IGBP1 Gene

  1. Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway. (PMID: 9441740) Onda M. … Sakaguchi N. (Genomics 1997) 2 3 4 23
  2. A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the alpha 4 gene at Xq13. (PMID: 14556245) Graham J.M. Jr. … Cox T.C. (Am. J. Med. Genet. A 2003) 3 4 23
  3. Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42. (PMID: 16517231) Smetana J.H. … Zanchin N.I. (Biochim. Biophys. Acta 2006) 3 23
  4. Alpha 4 associates with protein phosphatases 2A, 4, and 6. (PMID: 9647778) Chen J. … Schreiber S.L. (Biochem. Biophys. Res. Commun. 1998) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for IGBP1 Gene

Sources for IGBP1 Gene

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