Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGBP1 Gene

protein-coding GIFtS: 61
GCID: GC0XP069353

immunoglobulin (CD79A) binding protein 1

(Previous symbol: IBP1)

Explore 21 diseases affiliated with
IGBP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Immunoglobulin (CD79A) Binding Protein 1¹ ²		CD79a-Binding Protein 1² ³
IBP1¹ ² ³		ALPHA-4²
Protein Alpha-4² ³		B Cell Signal Transduction Molecule Alpha 4²
Protein Phosphatase 2/4/6 Regulatory Subunit² ³		BA351K23.1 (Immunoglobulin Binding Protein 1 (CD79A) )²
Renal Carcinoma Antigen NY-REN-16² ³		Immunoglobulin-Binding Protein 1²
B-Cell Signal Transduction Molecule Alpha 4² ³		Protein Phosphatase 2A, Regulatory Subunit Alpha-4²

External Ids:	HGNC: 5461¹	Entrez Gene: 3476²	Ensembl: ENSG00000089289⁷	OMIM: 300139⁵	UniProtKB: P78318³

Export aliases for IGBP1 gene to outside databases

Previous GC identifers: GC0XP065531 GC0XP066830 GC0XP067586 GC0XP068220 GC0XP069136 GC0XP069270 GC0XP063174

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGBP1:

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of

antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads

to multiple signal transduction pathways. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IGBP1_HUMAN, P78318

Function: Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the

catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative

polyubiquitination until they associate with regulatory subunits

Gene Wiki entry for IGBP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011669.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGBP1 gene promoter:
RFX1 AP-1 ATF-2 MyoD STAT3 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IGBP1 promoter sequence

Search SABiosciences Chromatin IP Primers for IGBP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGBP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1-q13.3 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1-q13.3

IGBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGBP1 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP069353: view genomic region (about GC identifiers)

Start:	69,353,299 bp from pter	End:	69,386,174 bp from pter
Size:	32,876 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IGBP1_HUMAN, P78318 (See protein sequence)

Recommended Name: Immunoglobulin-binding protein 1

Size: 339 amino acids; 39222 Da

Subunit: Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and

MID2. Interacts with Ubiquitin

Subcellular location: Cytoplasm (Potential)

Secondary accessions: Q8TAB2

Explore the universe of human proteins at neXtProt for IGBP1: NX_P78318

Post-translational modifications:

Phosphorylated (By similarity)¹

Monoubiquitination by MID1 triggers calpain-mediated cleavage and switches IGBP1 activity from protective to

destructive¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P78318

IGBP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001542.1

ENSEMBL proteins:

ENSP00000363661 ENSP00000348784

Human Recombinant Protein Products for IGBP1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IGBP1 OriGene Protein Over-expression Lysate: IGBP1 OriGene Custom Protein Services for IGBP1
	GenScript Custom Purified and Recombinant Proteins Services for IGBP1
	Novus Biologicals IGBP1 Proteins Novus Biologicals IGBP1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IGBP1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	9647778

IGBP1 for ontologies About GeneDecksing

IGBP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IGBP1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for IGBP1
	OriGene Antibodies: IGBP1 OriGene Custom Antibody Services for IGBP1
	GenScript Custom Superior Antibodies Services for IGBP1
	Novus Biologicals IGBP1 Antibodies
	Abcam antibodies for IGBP1
	Uscn Antibodies for IGBP1
	Search ThermoFisher Antibodies for IGBP1

Assay Products for IGBP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IGBP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IGBP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGBP1 for domains About GeneDecksing

1 InterPro domain/family:

IPR007304 TAP42-like

Graphical View of Domain Structure for InterPro Entry P78318

ProtoNet protein and cluster: P78318

1 Blocks protein family: IPB007304 TAP42-like protein

UniProtKB/Swiss-Prot: IGBP1_HUMAN, P78318

Domain: The UIM domain is required for protective effect on PP2A (By similarity)

Similarity: Belongs to the IGBP1/TAP42 family

Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IGBP1_HUMAN, P78318

Function: Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the

catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative

polyubiquitination until they associate with regulatory subunits

Genatlas biochemistry entry for IGBP1:

B cell signal transduction molecule alpha 4,45kDa,expressed preferentially in heart,skeletal muscle and

pancreas,similar to yeast TAP42 protein

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008601	protein phosphatase type 2A regulator activity	IDA	9647778
GO:0031434	mitogen-activated protein kinase kinase binding	IEA	--

IGBP1 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for IGBP1:

Decreased focal adhesion (FA)

Downregulation of NF-kappaB pa

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Igbp1):

behavior/neurological

cellular

hematopoietic system

immune system

nervous system

IGBP1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IGBP1

miRNA Products:		OriGene 3'-UTR Clone: IGBP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGBP1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate IGBP1:
		hsa-miR-514 hsa-miR-330-3p hsa-miR-514b-3p hsa-let-7f-2* hsa-miR-1272
		SwitchGear 3'UTR luciferase reporter plasmid: IGBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGBP1 (see all 7) OriGene shRNA RFP: IGBP1 OriGene siRNA: IGBP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGBP1
		Sirion Biotech Custom design and validation of potent shRNA sequences against IGBP1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IGBP1
			Sirion Biotech Customized adenovirus for overexpression of IGBP1 Sirion Biotech Customized adenovirus for potent knockdown of IGBP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGBP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGBP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IGBP1 (NM_001551)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGBP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGBP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGBP1
		Search LifeMap BioReagents cell lines for IGBP1
		Sirion Biotech Customized stable knockdown cell line services for IGBP1 Sirion Biotech Customized inducible knockdown cell line services for IGBP1 Sirion Biotech Customized stable overexpressing cell line services for IGBP1 Sirion Biotech Customized inducible overexpressing cell line services for IGBP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGBP1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_CNTF receptor signaling

Translation _Regulation of EIF4F activity

0.32

Translation Regulation activity of EIF4F

0.32

Phosphatases

Phosphatases

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IGBP1

Translation Regulation activity of EIF4F

1 Cell Signaling Technology (CST) Pathway for IGBP1

Phosphatases

1 GeneGo (Thomson Reuters) Pathway for IGBP1

Translation Regulation of EIF4F activity

IGBP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IGBP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/43 Interacting proteins for IGBP1 (P78318^{1, 2, 3} ENSP00000348784⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 43)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP2CB	P62714¹^,³, ENSP00000221138⁴	EBI-1055954,EBI-1044367 I2D: score=4 STRING: ENSP00000221138
PPP4C	P60510¹^,²^,³, ENSP00000279387⁴	EBI-1055954,EBI-1046072 MINT-8208540 I2D: score=10 STRING: ENSP00000279387
PPP2CA	P67775¹^,³, ENSP00000418447⁴	EBI-1055954,EBI-712311 I2D: score=7 STRING: ENSP00000418447
PPP6C	O00743¹^,³, ENSP00000392147⁴	EBI-1055954,EBI-359751 I2D: score=4 STRING: ENSP00000392147
CCT7	Q99832³, ENSP00000258091⁴	I2D: score=2 STRING: ENSP00000258091

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	17438131
GO:0007165	signal transduction	NAS	9647778
GO:0032873	negative regulation of stress-activated MAPK cascade	IMP	17438131
GO:0034612	response to tumor necrosis factor	IMP	17438131
GO:0035306	positive regulation of dephosphorylation	IEA	--

IGBP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGBP1
Search CenterWatch for drugs/clinical trials and news about IGBP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IGBP1 gene:

NM_001551.2

Unigene Cluster for IGBP1:

Immunoglobulin (CD79A) binding protein 1

Hs.496267 [show with all ESTs]

Unigene Representative Sequence: AK054596

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000342206(uc004dxv.3) ENST00000356413(uc004dxw.3)

miRNA Products:		OriGene 3'-UTR Clone: IGBP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGBP1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate IGBP1:
		hsa-miR-514 hsa-miR-330-3p hsa-miR-514b-3p hsa-let-7f-2* hsa-miR-1272
		SwitchGear 3'UTR luciferase reporter plasmid: IGBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGBP1 (see all 7) OriGene shRNA RFP: IGBP1 OriGene siRNA: IGBP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGBP1
		Sirion Biotech Custom design and validation of potent shRNA sequences against IGBP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGBP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGBP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IGBP1 (NM_001551)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGBP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGBP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGBP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IGBP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGBP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGBP1

Additional cDNA sequence:

AK054596.1 AK315660.1 BC004137.2 BT006736.1 CR456782.1 Y08915.1

14 DOTS entries:

DT.441847 DT.100885281 DT.100764642 DT.121286211 DT.121286183 DT.92330093 DT.91870576 DT.100701459

DT.100713912 DT.100885274 DT.100885276 DT.121286213 DT.91846916 DT.91702885

24/348 AceView cDNA sequences (see all 348):

BM811499 AA453327 CR604445 AW651694 AA028061 AA970639 BQ478234 CD107481

BG028398 BC004137 BE384475 CN481519 BI754791 BU159758 BX347016 BE887433

AL040946 BM981588 AK054596 BM824701 NM_001551 BX401271 BQ228052 BI522593

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IGBP1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c
SP1:
SP2:
SP3:									-		-		-		-
SP4:																	-
SP5:									-

ECgene alternative splicing isoforms for IGBP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTATTCCA

About this image

IGBP1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IGBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGBP1

SOURCE GeneReport for Unigene cluster: Hs.496267

UniProtKB/Swiss-Prot: IGBP1_HUMAN, P78318

Tissue specificity: Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas

SABiosciences Custom PCR Arrays for IGBP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGBP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IGBP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGBP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGBP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGBP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for IGBP1 gene from 10/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Igbp1^{1 , 5}	immunoglobulin (CD79A) binding protein 1^{1, 5}	86.69(n)¹ 80.47(a)¹		X (43.72 cM)⁵ 18518¹ NM_008784.3¹ NP_032810.4¹ 100494291⁵
chicken (Gallus gallus)	Aves	IGBP1¹	immunoglobulin (CD79A) binding protein 1	64.27(n) 59.32(a)		768951 XM_001231444.2 XP_001231445.2
lizard (Anolis carolinensis)	Reptilia	IGBP1⁶	--	45(a)	1 ↔ 1	GL344027.1(41192-44476)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.1809²	Transcribed sequence with weak similarity to protein more	75.04(n)		141999944
zebrafish (Danio rerio)	Actinopterygii	Dr.17830²	Danio rerio mRNA similar to immunoglobulin (CD79A) more	70.58(n)		BC045313.1
fruit fly (Drosophila melanogaster)	Insecta	Tap42¹	Two A-associated protein of 42kDa	47.2(n) 34.47(a)		326166 NM_165039.2 NP_723811.1
worm (Caenorhabditis elegans)	Secernentea	Y71H2B.3³ ppfr-4¹	Protein PPFR-4¹	29(a)³ 45.05(n)¹ 33.23(a)¹		III(2691757-2694159)³ 190617¹ NM_065190.3¹ NP_497591.1¹
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_ABR072W¹	ABR072Wp	43.75(n) 28.82(a)		4619122 NM_208371.1 NP_983018.1
thale cress (Arabidopsis thaliana)	eudicotyledons	TAP46¹	PP2A regulatory subunit TAP46	45.05(n) 30.97(a)		835379 NM_124679.2 NP_568783.1
rice (Oryza sativa)	Liliopsida	Os11g0141000¹	hypothetical protein	41.78(n) 31.34(a)		4349739 NM_001072246.1 NP_001065714.1

ENSEMBL Gene Tree for IGBP1 (if available)
TreeFam Gene Tree for IGBP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGBP1 gene

IGBP1 for paralogs About GeneDecksing

5/6 Pseudogenes.org Pseudogenes for IGBP1 (see all 6)
PGOHUM00000248129 PGOHUM00000259190 PGOHUM00000237574 PGOHUM00000245612 PGOHUM00000245871

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72628849^1,2	C	--	69351318(+)	`GAAGCA/GGGTGG`	1	--	us2k¹		1		NA	1
rs595828^1,2	C,A	--	69351532(+)	`agcctC/Gggtgg`	1	--	us2k¹		3		WA NA	6
rs3795171^1,2	C	--	69351603(+)	`AAATGG/ACTTAC`	1	--	us2k¹		1		NA	1
rs72628851^1,2	C	--	69351730(+)	`ACATTC/TCTAAG`	1	--	us2k¹		1		NA	1
rs3795172^1,2	C,H	--	69351761(+)	`TTTTTC/GTTTAT`	1	--	us2k¹ trp³		4		NS EA	418
rs186736885^1,2		--	69352057(+)	`TGAACG/TCAGAA`	1	--	us2k¹		0	--	--	--	--
rs200692137^1,2		--	69352213(+)	`CCTAG-/CATGGG`	1	--	us2k¹		0	--	--	--	--
rs191534235^1,2		--	69352533(+)	`AAATAC/TAATGG`	1	--	us2k¹		0	--	--	--	--
rs182367383^1,2		--	69352644(+)	`AAAAGA/CCTATC`	1	--	us2k¹		0	--	--	--	--
rs139731294^1,2		--	69352649(+)	`ACTATA/CATTTC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IGBP1 (69353299 - 69386174 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGBP1: --
Human Gene Mutation Database (HGMD): IGBP1

Locus Specific Mutation Databases (LSDB): IGBP1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGBP1

DNA2.0 Custom Variant and Variant Library Synthesis for IGBP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGBP1 for disorders           About GeneDecksing

OMIM gene information: 300139
OMIM disorders: 300472
UniProtKB/Swiss-Prot: IGBP1_HUMAN, P78318

Defects in IGBP1 are the cause of mental retardation syndromic X-linked type 28 (MRXS28) [MIM:300472]; also

known as agenesis of the corpus callosum with mental retardation, ocular coloboma and micrognathia. A syndrome that is

characterized by coloboma of the iris and optic nerve, severe retrognathia, intellectual deficit, and agenesis of the

corpus callosum

20/21 diseases for IGBP1 (see all 21): About MalaCards

agenesis of the corpus callosum with mental retardation, ocular coloboma, and micrognathia corpus callosum agenesis corpus callosum renal carcinoma

erythrokeratodermia variabilis cerebral cavernous malformations cavernous malformation progressive multifocal leukoencephalopathy

cerebral cavernous malformations 3 coloboma coloboma of iris carcinoma

fg syndrome renal cell carcinoma cerebritis hepatitis b

hermaphroditism lung adenocarcinoma adenocarcinoma myeloma

1 disease from the University of Copenhagen DISEASES database for IGBP1:

FG syndrome

Human Genome Epidemiology (HuGE) Navigator: IGBP1 (2 documents)

Export disorders for IGBP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGBP1 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with IGBP1)

Utopia: connect your pdf to the dynamic
world of online information

Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway. (PubMed id 9441740)^{1, 2, 3, 9} Onda M.... Sakaguchi N. (1997)
A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the alpha 4 gene at Xq13. (PubMed id 14556245)^{1, 2, 9} Graham J.M. Jr.... Cox T.C. (2003)
Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit alpha4, altering PP2A stability and microtubule-associated protein phosphorylation. (PubMed id 22613722)^{1, 2} Watkins G.R.... Wadzinski B.E. (2012)
Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination. (PubMed id 20092282)^{1, 2} McConnell J.L....Wadzinski B.E. (2010)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
MID1 and MID2 homo- and heterodimerise to tether the rapamycin- sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders. (PubMed id 11806752)^{1, 2} Short K.M.... Cox T.C. (2002)
Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)^{1, 2} Scanlan M.J....Old L.J. (1999)
Alpha 4 associates with protein phosphatases 2A, 4, and 6. (PubMed id 9647778)^{1, 2} Chen J.... Schreiber S.L. (1998)
Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42. (PubMed id 16517231)^{1, 9} Smetana J.H....Zanchin N.I. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3476	HGNC: 5461	AceView: IGBP1	Ensembl:ENSG00000089289	euGenes: HUgn3476
ECgene: IGBP1	H-InvDB: IGBP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGBP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IGBP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IGBP1 gene:
Search GeneIP for patents involving IGBP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of IGBP1
	Browse Kits and Assays available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for IGBP1		OriGene shRNA RFP for IGBP1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGBP1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGBP1
	OriGene Protein Over-expression Lysate for IGBP1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for IGBP1		OriGene 3'-UTR Clone for IGBP1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGBP1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGBP1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for IGBP1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for IGBP1		OriGene Custom Protein Services for IGBP1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGBP1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGBP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGBP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGBP1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGBP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGBP1

	GenScript Custom Purified and Recombinant Proteins Services for IGBP1		GenScript cDNA clones with any tag delivered in your preferred vector for IGBP1
	GenScript Custom Assay Services for IGBP1		GenScript Custom Superior Antibodies Services for IGBP1
	GenScript Custom overexpressing Cell Line Services for IGBP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for IGBP1

	Regulatory tfbs in IGBP1 promoter
	Search Chromatin IP Primers for IGBP1
	RT² qPCR Primer Assay in human, mouse, rat IGBP1
	GNC Network for IGBP1
	SABiosciences Custom PCR Arrays for IGBP1

Search Tocris compounds for IGBP1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	IGBP1 antibodies
	IGBP1 proteins
	IGBP1 lysates

	Antibodies for IGBP1
	See all of Abcam's Antibodies, Kits and Proteins for IGBP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

IGBP1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for IGBP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGBP1

	SwitchGear 3'UTR luciferase reporter plasmids for IGBP1
	SwitchGear Promoter luciferase reporter plasmids for IGBP1

Search ThermoFisher Antibodies for IGBP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGBP1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IGBP1

Sirion Biotech Customized:

	stable knockdown cell line services for IGBP1
	inducible knockdown cell line services for IGBP1
	design and validation of potent shRNA sequences against IGBP1
	adenovirus for potent knockdown of IGBP1
	adenovirus for overexpression of IGBP1
	stable overexpressing cell line services for IGBP1
	inducible overexpressing cell line services for IGBP1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IGBP1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

IGBP1 Gene

immunoglobulin (CD79A) binding protein 1

Aliases
for IGBP1 gene

Summaries
for IGBP1 gene

Genomic Views
for IGBP1 gene

Proteins
for IGBP1 gene

Protein Domains /
Families
for IGBP1 gene

Function
for IGBP1 gene

Pathways & Interactions
for IGBP1 gene

Drugs & Compounds
for IGBP1 gene

Transcripts
for IGBP1 gene

Expression
for IGBP1 gene

Orthologs
for IGBP1 gene

Paralogs
for IGBP1 gene

Genomic Variants
for IGBP1 gene

Disorders / Diseases
for IGBP1 gene

Publications
for IGBP1 gene

External Searches for IGBP1 gene

Genome Databases showing IGBP1 gene

Other Databases showing IGBP1 gene

Specialized Databases showing IGBP1 gene

Intellectual Property
for IGBP1 gene

Products
for IGBP1 gene

View Random Gene

Advanced Search

Export list of displayed genes

IGBP1 Gene

immunoglobulin (CD79A) binding protein 1

Aliasesfor IGBP1 gene

Summariesfor IGBP1 gene

Genomic Viewsfor IGBP1 gene

Proteinsfor IGBP1 gene

Protein Domains /Familiesfor IGBP1 gene

Functionfor IGBP1 gene

Pathways & Interactionsfor IGBP1 gene

Drugs & Compoundsfor IGBP1 gene

Transcriptsfor IGBP1 gene

Expression for IGBP1 gene

Orthologsfor IGBP1 gene

Paralogsfor IGBP1 gene

Genomic Variantsfor IGBP1 gene

Disorders / Diseasesfor IGBP1 gene

Publicationsfor IGBP1 gene

External Searches for IGBP1 gene

Genome Databases showing IGBP1 gene

Other Databases showing IGBP1 gene

Specialized Databases showing IGBP1 gene

Intellectual Propertyfor IGBP1 gene

Productsfor IGBP1 gene

View Random Gene

Aliases
for IGBP1 gene

Summaries
for IGBP1 gene

Genomic Views
for IGBP1 gene

Proteins
for IGBP1 gene

Protein Domains /
Families
for IGBP1 gene

Function
for IGBP1 gene

Pathways & Interactions
for IGBP1 gene

Drugs & Compounds
for IGBP1 gene

Transcripts
for IGBP1 gene

Expression
for IGBP1 gene

Orthologs
for IGBP1 gene

Paralogs
for IGBP1 gene

Genomic Variants
for IGBP1 gene

Disorders / Diseases
for IGBP1 gene

Publications
for IGBP1 gene

Intellectual Property
for IGBP1 gene

Products
for IGBP1 gene