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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFT88 Gene

protein-coding   GIFtS: 56
GCID: GC13P021141

intraflagellar transport 88 homolog (Chlamydomonas)

(Previous name: tetratricopeptide repeat domain 10 )
(Previous symbol: TTC10)
 Explore 15 diseases affiliated with
IFT88 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IFT88    

Aliases
for IFT88 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Intraflagellar Transport 88 Homolog (Chlamydomonas)1 2     TPR Repeat Protein 102 3
TTC101 2 3     MGC262591
D13S1056E1 2 5     Tg7371
TG7372 3 5     DAF192
HTg7371     Intraflagellar Transport Protein 88 Homolog2
Tetratricopeptide Repeat Domain 101 2     Polaris Homolog2
Recessive Polycystic Kidney Disease Protein Tg737 Homolog2 3     Probe HTg737 (Polycystic Kidney Disease, Autosomal Recessive)2
Tetratricopeptide Repeat Protein 102 3     

External Ids:    HGNC: 206061   Entrez Gene: 81002   Ensembl: ENSG000000327427   OMIM: 6005955   UniProtKB: Q130993   

Export aliases for IFT88 gene to outside databases

Previous GC identifers: GC13P020039 GC13P001944


Summaries
for IFT88 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IFT88:
This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can
cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this
gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IFT88_HUMAN, Q13099
Function: Involved in primary cilium biogenesis (By similarity)

Gene Wiki entry for IFT88


Genomic Views
for IFT88 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFT88 gene promoter:
         Pax-2   Pax-2a   E47   C/EBPalpha   Pax-2b   POU2F1   POU2F1a   POU2F1b   Hand1   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFT88 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFT88

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFT88


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.1   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q12.1

IFT88 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFT88 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P021141:  view genomic region     (about GC identifiers)

Start:
 21,140,585 bp from pter      End:
 21,265,576 bp from pter
Size:
 124,992 bases      Orientation:
 plus strand

Proteins
for IFT88 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IFT88_HUMAN, Q13099 (See protein sequence)
Recommended Name: Intraflagellar transport protein 88 homolog  
Size: 833 amino acids; 94270 Da
Subunit: Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20. Interacts with
IFT46, IFT57 and IFT172 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole (By similarity). Cytoplasm, cytoskeleton, cilium
basal body (By similarity)
Secondary accessions: A2A491 B4DUS2 Q5SZJ6 Q8N719
Alternative splicing: 3 isoforms:  Q13099-1   Q13099-2   Q13099-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IFT88: NX_Q13099

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13099

    • IFT88 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_006522.2  NP_783195.2  

    ENSEMBL proteins: 
     ENSP00000261632   ENSP00000323580   ENSP00000374024   ENSP00000372228   ENSP00000437719  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IFT88

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005814centriole ISS--
    GO:0005929cilium ISS--
    GO:0005930axoneme ----
    GO:0005932microtubule basal body ISS--
    GO:0030992intraflagellar transport particle B ISS--


    IFT88 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for IFT88 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IFT88 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011990 TPR-like_helical
     IPR006597 Sel1-like
     IPR001440 TPR-1
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q13099

    ProtoNet protein and cluster: Q13099

    UniProtKB/Swiss-Prot: IFT88_HUMAN, Q13099
    Similarity: Contains 12 TPR repeats


    Function
    for IFT88 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IFT88_HUMAN, Q13099
    Function: Involved in primary cilium biogenesis (By similarity)

    miRNA
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    hsa-miR-3145-3p
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    Inhib. RNA
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    OriGene shRNA RFP: IFT88
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    IFT88 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for IFT88:
     Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Ift88tm1.1Bky for IFT88
         15/17 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Ift88) (see all 17):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  renal/urinary system  respiratory system 

    IFT88 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IFT88 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Hedgehog signaling events mediated by Gli proteins
    		Hedgehog signaling events mediated by Gli proteins1.00
    2Endochondral Ossification
    		Endochondral Ossification1.00


    2 BioSystems Pathways for IFT88 
        Endochondral Ossification
    Hedgehog signaling events mediated by Gli proteins


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFT88

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/20 Interacting proteins for IFT88 (Q130992, 3 ENSP000003235804) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBCCD1Q9NVR72, ENSP000003416524MINT-7716678 MINT-7716872 MINT-7716858 STRING: ENSP00000341652
    PRRC2AP486343, ENSP000003651754I2D: score=3 STRING: ENSP00000365175
    SMNDC1O759403, ENSP000003586054I2D: score=1 STRING: ENSP00000358605
    ACTR6Q9GZN13I2D: score=3 
    SLC9A8Q9Y2E83I2D: score=3 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0003382epithelial cell morphogenesis IEA--
    GO:0007224smoothened signaling pathway IEA--
    GO:0007368determination of left/right symmetry IEA--
    GO:0007399nervous system development ----


    IFT88 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IFT88 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFT88
    Search CenterWatch for drugs/clinical trials and news about IFT88 

    Transcripts
    for IFT88 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IFT88 gene (2 alternative transcripts): 
    NM_006531.3  NM_175605.3  

    Unigene Cluster for IFT88:

    Intraflagellar transport 88 homolog (Chlamydomonas)
    Hs.187376  [show with all ESTs]
    Unigene Representative Sequence: AK126668
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351808(uc001uni.3 uc010tcq.2) ENST00000319980 ENST00000389373
    ENST00000461115(uc001unl.1) ENST00000482172 ENST00000460931 ENST00000470695
    ENST00000382778(uc001unh.3 uc001unj.3) ENST00000537103(uc001unk.3)


    miRNA
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    hsa-miR-3145-3p
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK058172.1 AK126668.1 AK300769.1 AK303853.1 AK308281.1 AK310223.1 BC030776.1 BC059357.1 
    BX640833.1 U20362.1 

    18 DOTS entries:

    DT.100781404  DT.99987212  DT.454660  DT.95294622  DT.92352829  DT.100781399  DT.100734545  DT.92428908 
    DT.95228011  DT.100781400  DT.40298943  DT.99985007  DT.120780655  DT.120780691  DT.95158998  DT.95319806 
    DT.213555  DT.99969390 

    24/139 AceView cDNA sequences (see all 139):

    CA944575 CD358688 AL705597 AU133199 BQ010507 AU124457 CB250630 AI436331 
    AA425693 NM_175605 CD557681 NM_006531 BC059357 CD359534 AA825841 AI190456 
    AI369405 N76894 AA481279 BE552147 BF916037 CA396451 CA313424 AL705257 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IFT88 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                                    -                                                                                       
    SP2:                                                                    -                                                                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                  -                 -                                       
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for IFT88

    Expression
    for IFT88 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFT88 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAAACCTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IFT88 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFT88

    SOURCE GeneReport for Unigene cluster: Hs.187376

    UniProtKB/Swiss-Prot: IFT88_HUMAN, Q13099
    Tissue specificity: Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including IFT88: 
              Primary Cilia in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for IFT88 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for IFT88 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ift881 , 5 intraflagellar transport 88 homolog (Chlamydomonas) less5
    intraflagellar transport 881    		 87.14(n)1
    89.44(a)1    		   14 (30.10 cM)5
    218211  NM_009376.21  NP_033402.21 
     574240625 
    chicken
    (Gallus gallus)    		 Aves IFT881 intraflagellar transport 88 homolog (Chlamydomonas) less 78.7(n)
    81.46(a)    		   418952  XM_417145.3  XP_417145.2 
    lizard
    (Anolis carolinensis)    		 Reptilia IFT886
    		 --
    		 80(a)
    		 1 ↔ 1
    		 3(187457140-187501386)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.133782 Xenopus laevis transcribed sequence with moderate similarity to protein spQ13099 (H.sapiens) TG37_HUMAN Recessive polycystic kidney disease protein Tg737 homolog less 78.52(n)    AW644323.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb37b112 Transcribed sequence with moderate similarity to protein spQ13099 (H.sapiens) TG37_HUMAN Recessive polycystic kidney disease protein Tg737 homolog less 72.56(n)    BQ077806.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta nompB1 no mechanoreceptor potential B 45.95(n)
    39.08(a)    		   35414  NM_165385.3  NP_724347.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea osm-51 Protein OSM-5 53.95(n)
    47.4(a)    		   180585  NM_076110.3  NP_508511.1 


    ENSEMBL Gene Tree for IFT88 (if available)
    TreeFam Gene Tree for IFT88 (if available) 

    Paralogs
    for IFT88 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for IFT88 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2262 NCBI SNPs in IFT88 are shown (see all 2262)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1164523241,2
    		F,--21139273(+) ATGCCG/ACCACT 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1810366391,2
    		--21139297(+) GGCTAC/TAGAGC 2 -- us2k10--------
    rs95783031,2
    		C,--21139302(+) tagagC/Tgagac 2 -- us2k13Minor allele frequency- T:0.08CSA WA NA 240
    rs574235651,2
    		C,F,--21139313(+) TCTGTC/GTCAAT 2 -- us2k13Minor allele frequency- G:0.07WA CSA NA 124
    rs1122200971,2
    		C,--21139370(+) CAATCT/-TTTTC 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1431781301,2
    		--21139489(+) AACCAA/CTTACC 2 -- us2k10--------
    rs1843725561,2
    		--21139495(+) TTACCC/TGGTCA 2 -- us2k10--------
    rs1142979781,2
    		F,--21139596(+) CGTCAG/AGAATA 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1475106891,2
    		--21139609(+) AACCCC/GTTCGC 2 -- us2k10--------
    rs1392840241,2
    		--21139737(+) TTTTGC/TGGCAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFT88 (21140585 - 21265576 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for IFT88
         4 CNVs: 7002 39123 3004 3905

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    Disorders / Diseases
    for IFT88 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IFT88 for disorders           About GeneDecksing

    OMIM gene information: 600595    OMIM disorders: --

    15 diseases for IFT88:    About MalaCards
    polycystic kidney disease    kidney disease    polycystic kidney disease, autosomal recessive    bardet-biedl syndrome
    orofaciodigital syndrome    retinitis pigmentosa    cystic kidney    bipolar disorder
    polydactyly    hepatocellular carcinoma    retinitis    obesity
    schizophrenia    carcinoma    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for IFT88:
    Orofaciodigital syndrome     Cystic kidney     Polycystic kidney disease

    5 Novoseek disease relationships for IFT88 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arpkd 91.1 7 10200981 (1), 16207792 (1), 11322368 (1)
    polycystic kidney diseases 82.5 3 11251073 (1), 7633404 (1), 11062270 (1)
    tumor liver 47.5 6 9362446 (3), 10462374 (1)
    renal disease 31.6 1 8597639 (1)
    tumors 0 5 10462374 (2), 9362446 (2)

    Human Genome Epidemiology (HuGE) Navigator: IFT88 (1 document)

    Export disorders for IFT88 gene to outside databases

    Publications
    for IFT88 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFT88 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with IFT88)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene. (PubMed id 7633404)1, 2, 3, 9 Schrick J.J.... Woychik R.P. (1995)
    2. The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene. (PubMed id 9362446)1, 9 Isfort R.J....Woychik R.P. (1997)
    3. Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas. (PubMed id 10462374)1, 9 Bonura C....Brechot C. (1999)
    4. Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. (PubMed id 11251073)1, 9 Taulman P.D....Yoder B.K. (2001)
    5. New insights into the molecular pathophysiology of polycystic kidney disease. (PubMed id 10200981)1, 9 Murcia N.S....Avner E.D. (1999)
    6. Sequence analysis of the human hTg737 gene and its polymorphic sites in patients with autosomal recessive polycystic kidney disease. (PubMed id 8597639)1, 9 Onuchic L.F....Reeders S.T. (1995)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Gene therapy rescues cilia defects and restores olfact ory function in a mammalian ciliopathy model. (PubMed id 22941275)1 McIntyre J.C....Martens J.R. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. The cilia protein IFT88 is required for spindle orien tation in mitosis. (PubMed id 21441926)1 Delaval B....Doxsey S. (2011)

    External Searches for IFT88 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IFT88 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8100 HGNC: 20606 AceView: TTC10 Ensembl:ENSG00000032742 euGenes: HUgn8100
    ECgene: IFT88 H-InvDB: IFT88

    Other Databases showing IFT88 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IFT88 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFT88 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IFT88 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for IFT88 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IFT88 gene:
    Search GeneIP for patents involving IFT88

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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