Aliases for IFT88 Gene
External Ids for IFT88 Gene
Previous HGNC Symbols for IFT88 Gene
Previous GeneCards Identifiers for IFT88 Gene
This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for IFT88 Gene
IFT88 (Intraflagellar Transport 88) is a Protein Coding gene. Diseases associated with IFT88 include orofaciodigital syndrome i and polycystic kidney disease. Among its related pathways are Signaling by GPCR and Organelle biogenesis and maintenance. GO annotations related to this gene include kinesin binding.
UniProtKB/Swiss-Prot for IFT88 Gene
Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity).