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Aliases for IFT88 Gene

Aliases for IFT88 Gene

  • Intraflagellar Transport 88 2 3
  • TG737 3 4 6
  • Recessive Polycystic Kidney Disease Protein Tg737 Homolog 3 4
  • Tetratricopeptide Repeat Protein 10 3 4
  • Tetratricopeptide Repeat Domain 10 2 3
  • TPR Repeat Protein 10 3 4
  • Polaris Homolog 2 3
  • D13S1056E 3 6
  • TTC10 3 4
  • Probe HTg737 (Polycystic Kidney Disease, Autosomal Recessive) 3
  • Intraflagellar Transport 88 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport Protein 88 Homolog 3
  • Intraflagellar Transport 88 Homolog 3
  • HTg737 3
  • DAF19 3

External Ids for IFT88 Gene

Previous HGNC Symbols for IFT88 Gene

  • TTC10

Previous GeneCards Identifiers for IFT88 Gene

  • GC13P020039
  • GC13P021141
  • GC13P001944

Summaries for IFT88 Gene

Entrez Gene Summary for IFT88 Gene

  • This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFT88 Gene

IFT88 (Intraflagellar Transport 88) is a Protein Coding gene. Diseases associated with IFT88 include orofaciodigital syndrome and kidney disease. Among its related pathways are Endochondral Ossification and Hedgehog signaling events mediated by Gli proteins.

UniProtKB/Swiss-Prot for IFT88 Gene

  • Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity).

Gene Wiki entry for IFT88 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFT88 Gene

Genomics for IFT88 Gene

Regulatory Elements for IFT88 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IFT88 Gene

20,566,446 bp from pter
20,691,437 bp from pter
124,992 bases
Plus strand

Genomic View for IFT88 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFT88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFT88 Gene

Proteins for IFT88 Gene

  • Protein details for IFT88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intraflagellar transport protein 88 homolog
    Protein Accession:
    Secondary Accessions:
    • A2A491
    • B4DUS2
    • Q5SZJ6
    • Q8N719

    Protein attributes for IFT88 Gene

    833 amino acids
    Molecular mass:
    94270 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT20, IFT22, HSPB11, IFT27, IFT46, IFT52, TRAF3IP1, IFT57, IFT74, IFT80, IFT81, IFT88 AND IFT172. Interacts with C2CD3 (By similarity).

    Alternative splice isoforms for IFT88 Gene


neXtProt entry for IFT88 Gene

Proteomics data for IFT88 Gene at MOPED

Post-translational modifications for IFT88 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFT88 Gene

No data available for DME Specific Peptides for IFT88 Gene

Domains for IFT88 Gene

Gene Families for IFT88 Gene

  • IFT :Intraflagellar transport homologs
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for IFT88 Gene

Suggested Antigen Peptide Sequences for IFT88 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q13099
  • Contains 12 TPR repeats.
genes like me logo Genes that share domains with IFT88: view

Function for IFT88 Gene

Molecular function for IFT88 Gene

UniProtKB/Swiss-Prot Function: Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity).

Gene Ontology (GO) - Molecular Function for IFT88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019894 kinesin binding IEA --
genes like me logo Genes that share ontologies with IFT88: view
genes like me logo Genes that share phenotypes with IFT88: view

Animal Models for IFT88 Gene

MGI Knock Outs for IFT88:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IFT88 Gene

Localization for IFT88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFT88 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

Jensen Localization Image for IFT88 Gene COMPARTMENTS Subcellular localization image for IFT88 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for IFT88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005813 centrosome --
GO:0005814 centriole ISS --
GO:0005929 cilium ISS --
GO:0005930 axoneme --
genes like me logo Genes that share ontologies with IFT88: view

Pathways for IFT88 Gene

genes like me logo Genes that share pathways with IFT88: view

Pathways by source for IFT88 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IFT88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001654 eye development IEA --
GO:0001822 kidney development IEA --
GO:0001889 liver development IEA --
GO:0003382 epithelial cell morphogenesis IEA --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with IFT88: view

Transcripts for IFT88 Gene

Unigene Clusters for IFT88 Gene

Intraflagellar transport 88 homolog (Chlamydomonas):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFT88

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFT88 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: -
SP4: - -
SP7: -

Relevant External Links for IFT88 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFT88 Gene

mRNA expression in normal human tissues for IFT88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFT88 Gene

This gene is overexpressed in Testis (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFT88 Gene

SOURCE GeneReport for Unigene cluster for IFT88 Gene Hs.187376

mRNA Expression by UniProt/SwissProt for IFT88 Gene

Tissue specificity: Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
genes like me logo Genes that share expressions with IFT88: view

In Situ Assay Products

Orthologs for IFT88 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFT88 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFT88 35
  • 99.6 (n)
  • 99.76 (a)
IFT88 36
  • 100 (a)
(Bos Taurus)
Mammalia IFT88 35
  • 87.14 (n)
  • 89.81 (a)
IFT88 36
  • 89 (a)
(Canis familiaris)
Mammalia IFT88 35
  • 91.95 (n)
  • 90.9 (a)
IFT88 36
  • 90 (a)
(Mus musculus)
Mammalia Ift88 35
  • 87.14 (n)
  • 89.44 (a)
Ift88 16
Ift88 36
  • 89 (a)
(Monodelphis domestica)
Mammalia IFT88 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia IFT88 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Ift88 35
  • 84.55 (n)
  • 86.71 (a)
(Gallus gallus)
Aves IFT88 35
  • 78.31 (n)
  • 81 (a)
IFT88 36
  • 81 (a)
(Anolis carolinensis)
Reptilia IFT88 36
  • 80 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13378 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ift88 35
  • 74.03 (n)
  • 78.28 (a)
Str.14228 35
(Danio rerio)
Actinopterygii ift88 35
  • 70.93 (n)
  • 74.54 (a)
ift88 36
  • 72 (a)
wufb37b11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006324 35
  • 47.56 (n)
  • 42.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta nompB 35
  • 46.66 (n)
  • 40.11 (a)
nompB 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea osm-5 35
  • 53.42 (n)
  • 46.42 (a)
osm-5 36
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
Species with no ortholog for IFT88:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFT88 Gene

Gene Tree for IFT88 (if available)
Gene Tree for IFT88 (if available)

Paralogs for IFT88 Gene

Selected SIMAP similar genes for IFT88 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IFT88: view

No data available for Paralogs for IFT88 Gene

Variants for IFT88 Gene

Sequence variations from dbSNP and Humsavar for IFT88 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1052209 -- 20,642,711(+) TTTAC(C/T)ACCCA intron-variant
rs1052210 -- 20,642,783(+) TTCTT(A/G/T)TTTTT intron-variant
rs1065564 -- 20,689,619(+) ACTTT(G/T)TTTTA intron-variant
rs1329518 -- 20,629,472(+) GTAAA(C/G)TACTG intron-variant
rs1329519 -- 20,631,001(+) TTCAG(A/T)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFT88 Gene

Variant ID Type Subtype PubMed ID
dgv545e1 CNV Complex 17122850
nsv826580 CNV Gain 20364138
nsv832558 CNV Loss 17160897
esv33630 CNV Gain 17666407

Relevant External Links for IFT88 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFT88 Gene

Disorders for IFT88 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for IFT88 Gene including...

Search for IFT88 Gene in MalaCards »

(5) Novoseek inferred disease relationships for IFT88 Gene

Disease -log(P) Hits PubMed IDs
arpkd 91.1 3
polycystic kidney diseases 82.5 3
tumor liver 47.5 4
renal disease 31.6 1
tumors 0 4

Relevant External Links for IFT88

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IFT88: view

No data available for UniProtKB/Swiss-Prot for IFT88 Gene

Publications for IFT88 Gene

  1. Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene. (PMID: 7633404) Schrick J.J. … Woychik R.P. (Hum. Mol. Genet. 1995) 2 3 4 23
  2. Sequence analysis of the human hTg737 gene and its polymorphic sites in patients with autosomal recessive polycystic kidney disease. (PMID: 8597639) Onuchic L.F. … Reeders S.T. (Mamm. Genome 1995) 3 23
  3. The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene. (PMID: 9362446) Isfort R.J. … Woychik R.P. (Oncogene 1997) 3 23
  4. New insights into the molecular pathophysiology of polycystic kidney disease. (PMID: 10200981) Murcia N.S. … Avner E.D. (Kidney Int. 1999) 3 23
  5. Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas. (PMID: 10462374) Bonura C. … Brechot C. (Hepatology 1999) 3 23

Products for IFT88 Gene

Sources for IFT88 Gene

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