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IFT88 Gene

protein-coding   GIFtS: 59
GCID: GC13P021141

Intraflagellar Transport 88 Homolog (Chlamydomonas)

(Previous name: tetratricopeptide repeat domain 10)
(Previous symbol: TTC10)
  See IFT88-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Intraflagellar Transport 88 Homolog (Chlamydomonas)1 2     TPR Repeat Protein 102 3
TTC101 2 3     D13S1056E2 5
TG7372 3 5     DAF192
Tetratricopeptide Repeat Domain 101 2     hTg7372
Polaris Homolog1 2     Intraflagellar Transport Protein 88 Homolog2
Recessive Polycystic Kidney Disease Protein Tg737 Homolog2 3     Probe HTg737 (Polycystic Kidney Disease, Autosomal Recessive)2
Tetratricopeptide Repeat Protein 102 3     

External Ids:    HGNC: 206061   Entrez Gene: 81002   Ensembl: ENSG000000327427   OMIM: 6005955   UniProtKB: Q130993   

Export aliases for IFT88 gene to outside databases

Previous GC identifers: GC13P020039 GC13P001944


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFT88 Gene:
This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can
cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for IFT88 Gene:
IFT88 (intraflagellar transport 88 homolog (Chlamydomonas)) is a protein-coding gene. Diseases associated with IFT88 include polycystic kidney disease, autosomal recessive, and orofaciodigital syndrome.

UniProtKB/Swiss-Prot: IFT88_HUMAN, Q13099
Function: Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking
of ATG16L and the expansion of the autophagic compartment (By similarity)

Gene Wiki entry for IFT88 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFT88 gene promoter:
         Pax-2   Pax-2a   E47   C/EBPalpha   Pax-2b   POU2F1   POU2F1a   POU2F1b   Hand1   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFT88 promoter sequence
   Search Chromatin IP Primers for IFT88

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFT88


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.1   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q12.1

IFT88 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFT88 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P021141:  view genomic region     (about GC identifiers)

Start:
21,140,585 bp from pter      End:
21,265,576 bp from pter
Size:
124,992 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IFT88_HUMAN, Q13099 (See protein sequence)
Recommended Name: Intraflagellar transport protein 88 homolog  
Size: 833 amino acids; 94270 Da
Subunit: Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11/IFT25 and IFT20.
Interacts with IFT46, IFT57 and IFT172 (By similarity)
Secondary accessions: A2A491 B4DUS2 Q5SZJ6 Q8N719
Alternative splicing: 3 isoforms:  Q13099-1   Q13099-2   Q13099-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IFT88: NX_Q13099

Explore proteomics data for IFT88 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFT88 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006522.2  NP_783195.2  

    ENSEMBL proteins: 
     ENSP00000261632   ENSP00000323580   ENSP00000374024   ENSP00000372228   ENSP00000437719  

    IFT88 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for IFT88

     
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    antibodies-online proteins for IFT88 (2 products) 

     
    antibodies-online peptides for IFT88

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFT: Intraflagellar transport homologs
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR006597 Sel1-like
     IPR001440 TPR_1
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q13099

    ProtoNet protein and cluster: Q13099

    UniProtKB/Swiss-Prot: IFT88_HUMAN, Q13099
    Similarity: Contains 12 TPR repeats


    Find genes that share domains with IFT88           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFT88_HUMAN, Q13099
    Function: Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking
    of ATG16L and the expansion of the autophagic compartment (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IFT88           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IFT88:
     Increased G1 DNA content 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Ift88) (see all 17):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  renal/urinary system  respiratory system 

    Find genes that share phenotypes with IFT88           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IFT88: Ift88tm1.1Bky Ift88tm1(KOMP)Vlcg

       genOway: Develop your customized and physiologically relevant rodent model for IFT88

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate IFT88:
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    SwitchGear 3'UTR luciferase reporter plasmidIFT88 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFT88_HUMAN, Q13099: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (By
    similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005814centriole ISS--
    GO:0005929cilium ISS--
    GO:0005930axoneme IEA--
    GO:0030992intraciliary transport particle B ISS--
    GO:0031512motile primary cilium IEA--

    Find genes that share ontologies with IFT88           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFT88 About    
    See pathways by source

    SuperPathContained pathways About
    1Hedgehog signaling events mediated by Gli proteins
    Hedgehog signaling events mediated by Gli proteins
    2Endochondral Ossification
    Endochondral Ossification


    2 BioSystems Pathways for IFT88
        Endochondral Ossification
    Hedgehog signaling events mediated by Gli proteins


        Pathway & Disease-focused RT2 Profiler PCR Array including IFT88: 
              Primary Cilia in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IFT88

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for IFT88 (Q130992, 3 ENSP000003235804) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486343, ENSP000003874774I2D: score=3 STRING: ENSP00000387477
    ENSG00000231825P486343, ENSP000004153634I2D: score=3 STRING: ENSP00000415363
    PRRC2AP486343, ENSP000003651754I2D: score=3 STRING: ENSP00000365175
    ENSG00000206427P486343I2D: score=3 
    ENSG00000225164P486343I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001654eye development IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0003382epithelial cell morphogenesis IEA--
    GO:0007224smoothened signaling pathway IEA--
    GO:0007368determination of left/right symmetry IEA--

    Find genes that share ontologies with IFT88           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFT88



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFT88 gene (2 alternative transcripts): 
    NM_006531.3  NM_175605.3  

    Unigene Cluster for IFT88:

    Intraflagellar transport 88 homolog (Chlamydomonas)
    Hs.187376  [show with all ESTs]
    Unigene Representative Sequence: AK126668
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351808(uc001uni.3 uc010tcq.2) ENST00000319980 ENST00000389373
    ENST00000461115(uc001unl.1) ENST00000482172 ENST00000460931 ENST00000470695
    ENST00000382778(uc001unh.3 uc001unj.3) ENST00000537103(uc001unk.3)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate IFT88:
    hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidIFT88 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IFT88
    Predesigned siRNA for gene silencing in human, mouse, rat IFT88
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    GenScript: all cDNA clones in your preferred vector (see all 2): IFT88 (NM_006531)
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      QuantiFast Probe-based Assays in human, mouse, rat IFT88

    Additional mRNA sequence: 

    AK058172.1 AK126668.1 AK300769.1 AK303853.1 AK308281.1 AK310223.1 BC030776.1 BC059357.1 
    BX640833.1 U20362.1 

    18 DOTS entries:

    DT.100781404  DT.99987212  DT.454660  DT.95294622  DT.92352829  DT.100781399  DT.100734545  DT.92428908 
    DT.95228011  DT.100781400  DT.40298943  DT.99985007  DT.120780655  DT.120780691  DT.95158998  DT.95319806 
    DT.213555  DT.99969390 

    Selected AceView cDNA sequences (see all 139):

    AU124457 CA396451 AI436331 CD358688 AI669646 AA825841 AL602825 AL705597 
    AL705257 AI190456 NM_006531 AU133199 CD359534 AA425693 AA481279 CD557681 
    CB250630 BE552147 N76894 AI369405 BF916037 BX281881 BC059357 BQ010507 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IFT88 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                                    -                                                                                       
    SP2:                                                                    -                                                                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                  -                 -                                       
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for IFT88

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFT88 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAACCTTG
    IFT88 Expression
    About this image


    IFT88 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             Seminiferous Tubules
    IFT88 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFT88 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.187376

    UniProtKB/Swiss-Prot: IFT88_HUMAN, Q13099
    Tissue specificity: Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including IFT88: 
              Primary Cilia in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFT88

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IFT88 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ift881 , 5 intraflagellar transport 88 homolog (Chlamydomonas)5
    intraflagellar transport 881
    87.14(n)1
    89.44(a)1
      14 (30.10 cM)5
    218211  NM_009376.21  NP_033402.21 
     574240625 
    chicken
    (Gallus gallus)
    Aves IFT881 intraflagellar transport 88 homolog (Chlamydomonas) 78.31(n)
    81(a)
      418952  XM_004938812.1  XP_004938869.1 
    lizard
    (Anolis carolinensis)
    Reptilia IFT886
    intraflagellar transport 88 homolog (Chlamydomonas...
    80(a)
    1 ↔ 1
    3(187453735-187505259)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133782 Xenopus laevis transcribed sequence with moderate similarity more 78.52(n)    AW644323.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb37b112 Transcribed sequence with moderate similarity to protein more 72.56(n)    BQ077806.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nompB1 no mechanoreceptor potential B 46.66(n)
    40.11(a)
      35414  NM_165385.3  NP_724347.2 
    worm
    (Caenorhabditis elegans)
    Secernentea osm-51 osm-5 53.42(n)
    46.42(a)
      180585  NM_076110.4  NP_508511.1 


    ENSEMBL Gene Tree for IFT88 (if available)
    TreeFam Gene Tree for IFT88 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFT88 gene
    1 SIMAP similar gene for IFT88 using alignment to 4 protein entries:     IFT88_HUMAN (see all proteins):
    DKFZp686B12213

    Find genes that share paralogs with IFT88           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFT88 (see all 2741)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341904521,2
    C--2167581(+) TTGTC-/TTTTTT 2 -- int10--------
    rs1164523241,2
    F--21139273(+) ATGCCG/ACCACT 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1810366391,2
    C--21139297(+) GGCTAC/TAGAGC 2 -- us2k10--------
    rs95783031,2
    C,F--21139302(+) tagagC/Tgagac 2 -- us2k13Minor allele frequency- T:0.08CSA WA NA 240
    rs574235651,2
    C,F--21139313(+) TCTGTC/GTCAAT 2 -- us2k13Minor allele frequency- G:0.07WA CSA NA 124
    rs1122200971,2
    C--21139370(+) CAATCT/-TTTTC 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1431781301,2
    --21139489(+) AACCAA/CTTACC 2 -- us2k10--------
    rs1843725561,2
    --21139495(+) TTACCC/TGGTCA 2 -- us2k10--------
    rs1142979781,2
    F--21139596(+) CGTCAG/AGAATA 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1475106891,2
    C--21139609(+) AACCCC/GTTCGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFT88 (21140585 - 21265576 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IFT88:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832558CNV Loss17160897
    esv33630CNV Gain17666407
    nsv826580CNV Gain20364138
    dgv545e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600595    OMIM disorders: --

    6 diseases for IFT88:    
    About MalaCards
    polycystic kidney disease, autosomal recessive    orofaciodigital syndrome    short-rib thoracic dysplasia 2 with or without polydactyly    kidney disease
    polycystic kidney disease    meckel syndrome 1

    4 diseases from the University of Copenhagen DISEASES database for IFT88:
    Orofaciodigital syndrome     Cystic kidney     Polycystic kidney disease     Bardet-Biedl syndrome

    Find genes that share disorders with IFT88           About GenesLikeMe

    5 Novoseek inferred disease relationships for IFT88 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arpkd 91.1 7 10200981 (1), 16207792 (1), 11322368 (1)
    polycystic kidney diseases 82.5 3 11251073 (1), 7633404 (1), 11062270 (1)
    tumor liver 47.5 6 9362446 (3), 10462374 (1)
    renal disease 31.6 1 8597639 (1)
    tumors 0 5 10462374 (2), 9362446 (2)

    Genetic Association Database (GAD): IFT88
    Human Genome Epidemiology (HuGE) Navigator: IFT88 (1 document)

    Export disorders for IFT88 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFT88 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with IFT88)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene. (PubMed id 7633404)1, 2, 3, 9 Schrick J.J.... Woychik R.P. (Hum. Mol. Genet. 1995)
    2. Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. (PubMed id 20713499)1, 4 Huang J....Smoller J.W. (Am J Psychiatry 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene. (PubMed id 9362446)1, 9 Isfort R.J....Woychik R.P. (Oncogene 1997)
    5. Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas. (PubMed id 10462374)1, 9 Bonura C....Brechot C. (Hepatology 1999)
    6. Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. (PubMed id 11251073)1, 9 Taulman P.D....Yoder B.K. (Mol. Biol. Cell 2001)
    7. New insights into the molecular pathophysiology of polycystic kidney disease. (PubMed id 10200981)1, 9 Murcia N.S....Avner E.D. (Kidney Int. 1999)
    8. Sequence analysis of the human hTg737 gene and its polymorphic sites in patients with autosomal recessive polycystic kidney disease. (PubMed id 8597639)1, 9 Onuchic L.F....Reeders S.T. (Mamm. Genome 1995)
    9. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PubMed id 23870195)1 Wojczynski M.K....Reilly M.P. (BMC Med. Genet. 2013)
    10. GWAS of dental caries patterns in the permanent dentition. (PubMed id 23064961)1 Shaffer J.R....Marazita M.L. (J. Dent. Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8100 HGNC: 20606 AceView: TTC10 Ensembl:ENSG00000032742 euGenes: HUgn8100
    ECgene: IFT88 H-InvDB: IFT88

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IFT88 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IFT88 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IFT88 gene:
    Search GeneIP for patents involving IFT88

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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