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Aliases for IFT74 Gene

Aliases for IFT74 Gene

  • Intraflagellar Transport 74 2 3 5
  • Coiled-Coil Domain-Containing Protein 2 3 4
  • Capillary Morphogenesis Gene 1 Protein 3 4
  • Capillary Morphogenesis Protein 1 2 3
  • Coiled-Coil Domain Containing 2 2 3
  • CCDC2 3 4
  • CMG-1 3 4
  • CMG1 3 4
  • Intraflagellar Transport 74 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport Protein 74 Homolog 3
  • Intraflagellar Transport 74 Homolog 3

External Ids for IFT74 Gene

Previous HGNC Symbols for IFT74 Gene

  • CCDC2

Summaries for IFT74 Gene

GeneCards Summary for IFT74 Gene

IFT74 (Intraflagellar Transport 74) is a Protein Coding gene. Among its related pathways are Intraflagellar transport and Organelle biogenesis and maintenance. GO annotations related to this gene include chromatin binding and beta-tubulin binding.

UniProtKB/Swiss-Prot for IFT74 Gene

  • Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.

Gene Wiki entry for IFT74 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFT74 Gene

Genomics for IFT74 Gene

Regulatory Elements for IFT74 Gene

Enhancers for IFT74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IFT74 on UCSC Golden Path with GeneCards custom track

Promoters for IFT74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for IFT74 Gene

Chromosome:
9
Start:
26,947,039 bp from pter
End:
27,066,129 bp from pter
Size:
119,091 bases
Orientation:
Plus strand

Genomic View for IFT74 Gene

Genes around IFT74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFT74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFT74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFT74 Gene

Proteins for IFT74 Gene

  • Protein details for IFT74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB3-IFT74_HUMAN
    Recommended name:
    Intraflagellar transport protein 74 homolog
    Protein Accession:
    Q96LB3
    Secondary Accessions:
    • Q3B789
    • Q5VY34
    • Q6PGQ8
    • Q9H643
    • Q9H8G7

    Protein attributes for IFT74 Gene

    Size:
    600 amino acids
    Molecular mass:
    69239 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT81; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts (via basic region) with beta-tubulin (via acidic region); interaction is direct. Interacts with ARL13B and IFT88.
    SequenceCaution:
    • Sequence=BAB14650.1; Type=Erroneous termination; Positions=159; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=BAB15423.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IFT74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFT74 Gene

Post-translational modifications for IFT74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFT74 Gene

Domains & Families for IFT74 Gene

Gene Families for IFT74 Gene

Protein Domains for IFT74 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFT74 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LB3

UniProtKB/Swiss-Prot:

IFT74_HUMAN :
  • Belongs to the IFT74 family.
Family:
  • Belongs to the IFT74 family.
genes like me logo Genes that share domains with IFT74: view

Function for IFT74 Gene

Molecular function for IFT74 Gene

UniProtKB/Swiss-Prot Function:
Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.

Gene Ontology (GO) - Molecular Function for IFT74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0048487 beta-tubulin binding IDA 23990561
genes like me logo Genes that share ontologies with IFT74: view
genes like me logo Genes that share phenotypes with IFT74: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFT74 Gene

Localization for IFT74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFT74 Gene

Cell projection, cilium. Cytoplasmic vesicle. Note=Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFT74 Gene COMPARTMENTS Subcellular localization image for IFT74 gene
Compartment Confidence
cytoskeleton 4
mitochondrion 3
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for IFT74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005813 centrosome IBA --
GO:0005929 cilium IBA --
GO:0016023 cytoplasmic, membrane-bounded vesicle IEA --
GO:0030992 intraciliary transport particle B ISS --
genes like me logo Genes that share ontologies with IFT74: view

Pathways & Interactions for IFT74 Gene

genes like me logo Genes that share pathways with IFT74: view

Pathways by source for IFT74 Gene

Gene Ontology (GO) - Biological Process for IFT74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003334 keratinocyte development IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0007368 determination of left/right symmetry IEA --
GO:0007507 heart development IEA --
GO:0008544 epidermis development IEA --
genes like me logo Genes that share ontologies with IFT74: view

No data available for SIGNOR curated interactions for IFT74 Gene

Drugs & Compounds for IFT74 Gene

No Compound Related Data Available

Transcripts for IFT74 Gene

Unigene Clusters for IFT74 Gene

Intraflagellar transport 74 homolog (Chlamydomonas):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFT74 Gene

No ASD Table

Relevant External Links for IFT74 Gene

GeneLoc Exon Structure for
IFT74
ECgene alternative splicing isoforms for
IFT74

Expression for IFT74 Gene

mRNA expression in normal human tissues for IFT74 Gene

Protein differential expression in normal tissues from HIPED for IFT74 Gene

This gene is overexpressed in Testis (24.4), Serum (16.2), and Adrenal (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IFT74 Gene



Protein tissue co-expression partners for IFT74 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IFT74 Gene:

IFT74

SOURCE GeneReport for Unigene cluster for IFT74 Gene:

Hs.145402

mRNA Expression by UniProt/SwissProt for IFT74 Gene:

Q96LB3-IFT74_HUMAN
Tissue specificity: Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus and spleen.
genes like me logo Genes that share expression patterns with IFT74: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for IFT74 Gene

Orthologs for IFT74 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFT74 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFT74 34
  • 90.61 (n)
  • 89.33 (a)
IFT74 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFT74 34
  • 91.56 (n)
  • 90.83 (a)
IFT74 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ift74 34
  • 88.18 (n)
  • 88.13 (a)
Ift74 16
Ift74 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IFT74 34
  • 99.39 (n)
  • 99.17 (a)
IFT74 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ift74 34
  • 88.46 (n)
  • 88.29 (a)
oppossum
(Monodelphis domestica)
Mammalia IFT74 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFT74 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves IFT74 34
  • 73.01 (n)
  • 66.72 (a)
IFT74 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFT74 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ift74 34
  • 70.69 (n)
  • 69.51 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:92052 34
  • 61.1 (n)
  • 60.24 (a)
CABZ01064447.1 35
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004724 34
  • 44.89 (n)
  • 31.93 (a)
worm
(Caenorhabditis elegans)
Secernentea ift-74 34
  • 47.12 (n)
  • 30.36 (a)
ift-74 35
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
Species where no ortholog for IFT74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFT74 Gene

ENSEMBL:
Gene Tree for IFT74 (if available)
TreeFam:
Gene Tree for IFT74 (if available)

Paralogs for IFT74 Gene

(6) SIMAP similar genes for IFT74 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with IFT74: view

No data available for Paralogs for IFT74 Gene

Variants for IFT74 Gene

Sequence variations from dbSNP and Humsavar for IFT74 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10812505 - 26,978,172(+) CCCAT(A/G)GGGAC reference, missense
rs12004404 - 26,984,279(+) TTACA(A/G)CTGAA reference, missense
rs17694549 - 27,009,102(+) TGTCT(C/T)TTGAA reference, missense
rs34628525 - 27,044,751(-) TCTGG(G/T)TCATT reference, missense
rs3429 - 27,062,723(-) CGCTG(A/G)TGCTA downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IFT74 Gene

Variant ID Type Subtype PubMed ID
esv2677119 CNV deletion 23128226
esv3620122 CNV loss 21293372
esv3620123 CNV loss 21293372
esv3891647 CNV gain 25118596
nsv1015259 CNV gain 25217958
nsv466334 CNV loss 19166990
nsv517269 CNV gain 19592680
nsv528614 CNV gain 19592680
nsv613944 CNV loss 21841781

Variation tolerance for IFT74 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.48; 94.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFT74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFT74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFT74 Gene

Disorders for IFT74 Gene

Relevant External Links for IFT74

Genetic Association Database (GAD)
IFT74
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFT74

No disorders were found for IFT74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFT74 Gene

Publications for IFT74 Gene

  1. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. (PMID: 11683410) Bell S.E. … Davis G.E. (J. Cell Sci. 2001) 2 3 4 65
  2. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. (PMID: 23990561) Bhogaraju S. … Lorentzen E. (Science 2013) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 65

Products for IFT74 Gene

Sources for IFT74 Gene

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