IFT74 Gene
protein-coding GIFtS: 45
GCID: GC09P026947
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intraflagellar transport 74 homolog (Chlamydomonas)(Previous name: coiled-coil domain containing 2 )
(Previous symbol: CCDC2)
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Aliases
for IFT74 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Intraflagellar Transport 74 Homolog (Chlamydomonas)1 2 | | Capillary Morphogenesis Gene 1 Protein2 3 | | CCDC21 2 3 5 | | Coiled-Coil Domain-Containing Protein 22 3 | | CMG11 2 3 5 | | FLJ226211 | | CMG-11 2 3 | | Capillary Morphogenesis Protein 12 | | Coiled-Coil Domain Containing 21 2 | | Intraflagellar Transport Protein 74 Homolog2 |
Export aliases for IFT74 gene to outside databases |
Summaries
for IFT74 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for IFT74
|
Genomic Views
for IFT74 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFT74 gene promoter:
AP-2beta AP-2gamma AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFT74
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFT74 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p21.2 Ensembl cytogenetic band: 9p21.2 HGNC cytogenetic band: 9p21.1IFT74 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P026947: view genomic region
(about GC identifiers)
Start:
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26,947,037 bp from pter |
End:
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27,062,931 bp from pter |
Size:
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115,895 bases |
Orientation:
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plus strand |
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Proteins
for IFT74 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFT74_HUMAN, Q96LB3 (See
protein sequence)Recommended Name: Intraflagellar transport protein 74 homolog Size: 600 amino acids; 69239 Da
Subcellular location: Cytoplasmic vesicle. Note=Intracellular vesicular compartment
Sequence caution: Sequence=BAB14650.1; Type=Erroneous termination; Positions=159; Note=Translated as Lys;Sequence=BAB15423.1; Type=Erroneous initiation;
Secondary accessions: Q3B789 Q5VY34 Q6PGQ8 Q9H643 Q9H8G7Alternative splicing: 2 isoforms: Q96LB3-1 Q96LB3-2 Explore the universe of human proteins at neXtProt for IFT74: NX_Q96LB3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96LB3
IFT74 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001092692.1 NP_001092693.1 NP_001092694.1 NP_079379.2
ENSEMBL proteins: ENSP00000430004 ENSP00000430096 ENSP00000369402 ENSP00000430526 ENSP00000393907 ENSP00000430742 ENSP00000389224 ENSP00000404122
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
IFT74 for ontologies About GeneDecksing
IFT74 Antibody Products:
Assay Products for IFT74: |
Protein
Domains /
Families
for IFT74 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96LB3 |
Function
for IFT74 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFT74 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFT74 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): IFT74 (NM_025103) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFT74 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFT74 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFT74 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003682 | chromatin binding |
IEA | -- |
IFT74 for ontologies About GeneDecksing
|
Pathways & Interactions
for IFT74 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFT74
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for IFT74 (ENSP000003694024) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0033630 | positive regulation of cell adhesion mediated by integrin |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IEA | -- |
IFT74 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFT74 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFT74
Search CenterWatch for drugs/clinical trials and news about IFT74
|
Transcripts
for IFT74 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFT74 gene (4 alternative transcripts): NM_001099222.1 NM_001099223.1 NM_001099224.1 NM_025103.2 Unigene Cluster for IFT74: Intraflagellar transport 74 homolog (Chlamydomonas) Hs.145402 [show with all ESTs]Unigene Representative Sequence: NM_00109922210 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000519968 ENST00000517444 ENST00000380062(uc003zqg.4) ENST00000518614
ENST00000429045(uc003zqf.4) ENST00000517866 ENST00000494236 ENST00000482986
ENST00000433700(uc010mja.3) ENST00000443698(uc010mjb.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFT74 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFT74 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): IFT74 (NM_025103) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFT74 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFT74 |
Additional cDNA sequence: AK023707.1 AK026274.1 AK225570.1 AY040325.1 BC023634.2 BC056875.1 BC107742.1 BC113524.1 BC113526.1 10 DOTS entries: DT.95369755 DT.40209770 DT.213564 DT.121169020 DT.99999977 DT.100024408 DT.101969749 DT.121169029 DT.121169056 DT.91731942 24/107 AceView cDNA sequences (see all 107): CA397989 BC023634 W95531 CR617782 AA804783 W95494 AI919195 AA975848 AI370731 CR621331 BG540890 AI630740 AA864905 CA397990 BG287033 CD677826 BM975339 CA425929 BC056875 AA029010 AY040325 BU569186 BM547440 BU567565
GeneLoc Exon Structure
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Expression
for IFT74 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFT74 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTTAGAGG
About this image
See IFT74 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFT74
SOURCE GeneReport for Unigene cluster: Hs.145402
UniProtKB/Swiss-Prot: IFT74_HUMAN, Q96LB3Tissue specificity: Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta,lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain andskeletal muscle or in fetal brain, thymus and spleen
SABiosciences Expression via Pathway-Focused PCR Array including IFT74:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFT74
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFT74 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFT74 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFT74 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFT74 |
Orthologs
for IFT74 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for IFT74 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for IFT74 (if available)
TreeFam Gene Tree for IFT74 (if available) |
Paralogs
for IFT74 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IFT74 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFT74 (26947037 - 27062931 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFT74
1 CNV: 52779 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFT74 |
|
Disorders
/ Diseases
for IFT74 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFT74 for disorders About GeneDecksing
OMIM gene information: 608040
OMIM disorders: --
5  diseases for IFT74: About MalaCardsamyotrophic lateral sclerosis frontotemporal dementia lateral sclerosis dementia
neuronitis
1 disease from the University of Copenhagen DISEASES database for IFT74:Frontotemporal dementia Export disorders for IFT74 gene to outside databases
|
Publications
for IFT74 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFT74 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with IFT74) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. (PubMed id 11683410)1, 2, 3 Bell S.E.... Davis G.E. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis. (PubMed id 17383054)1 Xiao S....Rogaeva E. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
|
External Searches for IFT74 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFT74 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFT74 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFT74 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFT74 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IFT74 gene:
Search GeneIP for patents involving IFT74
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFT74 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for IFT74 | | OriGene shRNA RFP for IFT74 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFT74 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFT74 | | | OriGene Protein Over-expression Lysate for IFT74 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IFT74 | | OriGene 3'-UTR Clone for IFT74 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFT74 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFT74 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | IFT74 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFT74 |
|  |  |  | | | | ThermoFisher Antibody for IFT74 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFT74 |
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