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Aliases for IFT74 Gene

Aliases for IFT74 Gene

  • Intraflagellar Transport 74 2 3
  • CCDC2 3 4 6
  • CMG1 3 4 6
  • Coiled-Coil Domain-Containing Protein 2 3 4
  • Capillary Morphogenesis Gene 1 Protein 3 4
  • Capillary Morphogenesis Protein 1 2 3
  • Coiled-Coil Domain Containing 2 2 3
  • CMG-1 3 4
  • Intraflagellar Transport 74 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport Protein 74 Homolog 3
  • Intraflagellar Transport 74 Homolog 3

External Ids for IFT74 Gene

Previous Symbols for IFT74 Gene

  • CCDC2

Summaries for IFT74 Gene

GeneCards Summary for IFT74 Gene

IFT74 (Intraflagellar Transport 74) is a Protein Coding gene. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for IFT74 Gene

  • Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.

Gene Wiki entry for IFT74 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFT74 Gene

Genomics for IFT74 Gene

Genomic Location for IFT74 Gene

Start:
26,947,039 bp from pter
End:
27,062,933 bp from pter
Size:
115,895 bases
Orientation:
Plus strand

Genomic View for IFT74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFT74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFT74 Gene

Regulatory Elements for IFT74 Gene

Proteins for IFT74 Gene

  • Protein details for IFT74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB3-IFT74_HUMAN
    Recommended name:
    Intraflagellar transport protein 74 homolog
    Protein Accession:
    Q96LB3
    Secondary Accessions:
    • Q3B789
    • Q5VY34
    • Q6PGQ8
    • Q9H643
    • Q9H8G7

    Protein attributes for IFT74 Gene

    Size:
    600 amino acids
    Molecular mass:
    69239 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT81; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts (via basic region) with beta-tubulin (via acidic region); interaction is direct. Interacts with ARL13B and IFT88.
    SequenceCaution:
    • Sequence=BAB14650.1; Type=Erroneous termination; Positions=159; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=BAB15423.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IFT74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFT74 Gene

Proteomics data for IFT74 Gene at MOPED

Post-translational modifications for IFT74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFT74 Gene

Domains for IFT74 Gene

Gene Families for IFT74 Gene

HGNC:
  • IFT :Intraflagellar transport homologs

Protein Domains for IFT74 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

IFT74_HUMAN
Family:
  • Belongs to the IFT74 family.:
    • Q96LB3
genes like me logo Genes that share domains with IFT74: view

Function for IFT74 Gene

Molecular function for IFT74 Gene

UniProtKB/Swiss-Prot Function: Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.

Gene Ontology (GO) - Molecular Function for IFT74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0048487 beta-tubulin binding IDA 23990561
genes like me logo Genes that share ontologies with IFT74: view
genes like me logo Genes that share phenotypes with IFT74: view

miRNA for IFT74 Gene

miRTarBase miRNAs that target IFT74

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IFT74 Gene

Localization for IFT74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFT74 Gene

Cell projection, cilium. Cytoplasmic vesicle. Note=Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFT74 Gene COMPARTMENTS Subcellular localization image for IFT74 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for IFT74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005813 centrosome IBA --
GO:0005929 cilium IBA --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0030992 intraciliary transport particle B ISS --
genes like me logo Genes that share ontologies with IFT74: view

Pathways for IFT74 Gene

SuperPathways for IFT74 Gene

No Data Available

Interacting Proteins for IFT74 Gene

Gene Ontology (GO) - Biological Process for IFT74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003334 keratinocyte development IEA --
GO:0006996 organelle organization TAS --
GO:0007219 Notch signaling pathway IEA --
GO:0008544 epidermis development --
GO:0033630 positive regulation of cell adhesion mediated by integrin IEA --
genes like me logo Genes that share ontologies with IFT74: view

No data available for Pathways by source for IFT74 Gene

Transcripts for IFT74 Gene

Unigene Clusters for IFT74 Gene

Intraflagellar transport 74 homolog (Chlamydomonas):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFT74 Gene

No ASD Table

Relevant External Links for IFT74 Gene

GeneLoc Exon Structure for
IFT74
ECgene alternative splicing isoforms for
IFT74

Expression for IFT74 Gene

mRNA expression in normal human tissues for IFT74 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFT74 Gene

SOURCE GeneReport for Unigene cluster for IFT74 Gene Hs.145402

mRNA Expression by UniProt/SwissProt for IFT74 Gene

Q96LB3-IFT74_HUMAN
Tissue specificity: Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus and spleen.
genes like me logo Genes that share expressions with IFT74: view

Orthologs for IFT74 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFT74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFT74 36
  • 99.39 (n)
  • 99.17 (a)
IFT74 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFT74 36
  • 90.61 (n)
  • 89.33 (a)
IFT74 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFT74 36
  • 91.56 (n)
  • 90.83 (a)
IFT74 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ift74 36
  • 88.18 (n)
  • 88.13 (a)
Ift74 16
Ift74 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IFT74 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFT74 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ift74 36
  • 88.46 (n)
  • 88.29 (a)
chicken
(Gallus gallus)
Aves IFT74 36
  • 73.01 (n)
  • 66.72 (a)
IFT74 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFT74 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ift74 36
  • 70.69 (n)
  • 69.51 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01064447.1 37
  • 50 (a)
OneToOne
zgc:92052 36
  • 61.1 (n)
  • 60.24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004724 36
  • 44.89 (n)
  • 31.93 (a)
worm
(Caenorhabditis elegans)
Secernentea ift-74 36
  • 47.12 (n)
  • 30.36 (a)
ift-74 37
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
Species with no ortholog for IFT74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFT74 Gene

ENSEMBL:
Gene Tree for IFT74 (if available)
TreeFam:
Gene Tree for IFT74 (if available)

Paralogs for IFT74 Gene

Selected SIMAP similar genes for IFT74 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with IFT74: view

No data available for Paralogs for IFT74 Gene

Variants for IFT74 Gene

Sequence variations from dbSNP and Humsavar for IFT74 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3429 - 27,062,723(-) CGCTG(A/G)TGCTA reference, missense
rs586213 -- 27,058,123(+) tcact(C/G)tgttg intron-variant
rs597492 -- 27,058,291(+) gctgt(A/T)ttgcc intron-variant
rs1129458 -- 27,056,378(+) AATGC(C/T)TTTAA reference, synonymous-codon
rs1413823 -- 26,960,777(-) CTTCA(C/T)CTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFT74 Gene

Variant ID Type Subtype PubMed ID
nsv528614 CNV Gain 19592680
nsv517269 CNV Gain 19592680
nsv892862 CNV Gain 21882294
nsv466334 CNV Loss 19166990
esv2677119 CNV Deletion 23128226

Relevant External Links for IFT74 Gene

HapMap Linkage Disequilibrium report
IFT74

Disorders for IFT74 Gene

(1) University of Copenhagen DISEASES for IFT74 Gene

Relevant External Links for IFT74

Genetic Association Database (GAD)
IFT74
genes like me logo Genes that share disorders with IFT74: view

No data available for UniProtKB/Swiss-Prot for IFT74 Gene

Publications for IFT74 Gene

  1. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. (PMID: 11683410) Bell S.E. … Davis G.E. (J. Cell Sci. 2001) 2 3 4
  2. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. (PMID: 23990561) Bhogaraju S. … Lorentzen E. (Science 2013) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for IFT74 Gene

Sources for IFT74 Gene

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