Aliases for IFT57 Gene
External Ids for IFT57 Gene
Previous Symbols for IFT57 Gene
GeneCards Summary for IFT57 Gene
IFT57 (Intraflagellar Transport 57) is a Protein Coding gene. Among its related pathways are fMLP Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..
UniProtKB/Swiss-Prot for IFT57 Gene
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5-AAAGACATG-3 present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.