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Aliases for IFT46 Gene

Aliases for IFT46 Gene

  • Intraflagellar Transport 46 2 3
  • Cilia And Flagella Associated Protein 32 2 3
  • C11orf60 3 4
  • C11orf2 3 4
  • Intraflagellar Transport 46 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport Protein 46 Homolog 3
  • Intraflagellar Transport Protein IFT46 3
  • Chromosome 11 Open Reading Frame 60 2
  • Intraflagellar Transport 46 Homolog 3
  • UPF0360 3
  • CFAP32 3

External Ids for IFT46 Gene

Previous HGNC Symbols for IFT46 Gene

  • C11orf60

Previous GeneCards Identifiers for IFT46 Gene

  • GC11M118415
  • GC11M114351

Summaries for IFT46 Gene

GeneCards Summary for IFT46 Gene

IFT46 (Intraflagellar Transport 46) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding.

UniProtKB/Swiss-Prot for IFT46 Gene

  • Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity).

Gene Wiki entry for IFT46 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFT46 Gene

Genomics for IFT46 Gene

Genomic Location for IFT46 Gene

Start:
118,544,528 bp from pter
End:
118,572,970 bp from pter
Size:
28,443 bases
Orientation:
Minus strand

Genomic View for IFT46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFT46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFT46 Gene

No data available for Regulatory Elements for IFT46 Gene

Proteins for IFT46 Gene

  • Protein details for IFT46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQC8-IFT46_HUMAN
    Recommended name:
    Intraflagellar transport protein 46 homolog
    Protein Accession:
    Q9NQC8
    Secondary Accessions:
    • A8K0F6
    • Q9H6V5

    Protein attributes for IFT46 Gene

    Size:
    304 amino acids
    Molecular mass:
    34286 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25/HSPB11, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT57, IFT88 and DAW1. Interacts with TTC26/IFT56 (By similarity). Interacts with ARL13B.

    Alternative splice isoforms for IFT46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFT46 Gene

Proteomics data for IFT46 Gene at MOPED

Post-translational modifications for IFT46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFT46 Gene

Domains for IFT46 Gene

Gene Families for IFT46 Gene

HGNC:
  • IFT :Intraflagellar transport homologs

Protein Domains for IFT46 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFT46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQC8

UniProtKB/Swiss-Prot:

IFT46_HUMAN :
  • Q9NQC8
Family:
  • Belongs to the IFT46 family.
genes like me logo Genes that share domains with IFT46: view

Function for IFT46 Gene

Molecular function for IFT46 Gene

UniProtKB/Swiss-Prot Function: Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for IFT46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
GO:0008022 protein C-terminus binding ISS --
genes like me logo Genes that share ontologies with IFT46: view

Phenotypes for IFT46 Gene

GenomeRNAi human phenotypes for IFT46:
genes like me logo Genes that share phenotypes with IFT46: view

miRNA for IFT46 Gene

miRTarBase miRNAs that target IFT46

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IFT46 Gene

Localization for IFT46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFT46 Gene

Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Note=Expression is concentrated at the cilium basal body but is also detected along the length of the cilium. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFT46 Gene COMPARTMENTS Subcellular localization image for IFT46 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for IFT46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IBA --
GO:0005929 cilium IBA --
GO:0030992 intraciliary transport particle B ISS --
GO:0031512 motile primary cilium IEA --
genes like me logo Genes that share ontologies with IFT46: view

Pathways for IFT46 Gene

SuperPathways for IFT46 Gene

No Data Available

Interacting Proteins for IFT46 Gene

Gene Ontology (GO) - Biological Process for IFT46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0007224 smoothened signaling pathway IEA --
GO:0008150 biological_process ND --
GO:0042073 intraciliary transport ISS --
GO:0042384 cilium assembly ISS --
genes like me logo Genes that share ontologies with IFT46: view

No data available for Pathways by source for IFT46 Gene

Transcripts for IFT46 Gene

Unigene Clusters for IFT46 Gene

Intraflagellar transport 46 homolog (Chlamydomonas):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFT46 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for IFT46 Gene

GeneLoc Exon Structure for
IFT46
ECgene alternative splicing isoforms for
IFT46

Expression for IFT46 Gene

mRNA expression in normal human tissues for IFT46 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFT46 Gene

SOURCE GeneReport for Unigene cluster for IFT46 Gene Hs.533738

genes like me logo Genes that share expressions with IFT46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFT46 Gene

Orthologs for IFT46 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFT46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFT46 35
  • 99.44 (n)
  • 99.44 (a)
IFT46 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFT46 35
  • 89.89 (n)
  • 94.48 (a)
IFT46 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFT46 35
  • 89.36 (n)
  • 92.91 (a)
IFT46 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ift46 35
  • 84.87 (n)
  • 90.78 (a)
Ift46 16
Ift46 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IFT46 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFT46 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ift46 35
  • 86.23 (n)
  • 90.78 (a)
chicken
(Gallus gallus)
Aves IFT46 35
  • 75.37 (n)
  • 81.53 (a)
IFT46 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFT46 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9932 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ift46 35
  • 70.83 (n)
  • 79.84 (a)
Str.15123 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7447 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14552 35
ift46 35
  • 72.24 (n)
  • 80 (a)
ift46 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15161 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dyf-6 35
  • 53.86 (n)
  • 47.29 (a)
dyf-6 36
  • 25 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5554 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for IFT46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFT46 Gene

ENSEMBL:
Gene Tree for IFT46 (if available)
TreeFam:
Gene Tree for IFT46 (if available)

Paralogs for IFT46 Gene

No data available for Paralogs for IFT46 Gene

Variants for IFT46 Gene

Sequence variations from dbSNP and Humsavar for IFT46 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs485444 -- 118,563,150(-) cttaa(A/G)gttca intron-variant
rs514958 -- 118,554,191(-) cgcct(A/G)tagtc intron-variant
rs516530 -- 118,567,341(+) ggagg(C/G)caagg upstream-variant-2KB
rs518896 -- 118,561,664(+) tgagt(C/T)ttagt intron-variant, upstream-variant-2KB
rs518899 -- 118,561,666(+) agttt(C/T)agtat intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFT46 Gene

Variant ID Type Subtype PubMed ID
dgv1319n71 CNV Loss 21882294
esv2666357 CNV Deletion 23128226
nsv7224 OTHER Inversion 18451855

Relevant External Links for IFT46 Gene

HapMap Linkage Disequilibrium report
IFT46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFT46 Gene

Disorders for IFT46 Gene

No disorders were found for IFT46 Gene.

No data available for UniProtKB/Swiss-Prot for IFT46 Gene

Publications for IFT46 Gene

  1. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien K.P. … Dumanski J.P. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Characterization of mouse IFT complex B. (PMID: 19253336) Follit J.A. … Pazour G.J. (Cell Motil. Cytoskeleton 2009) 2 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for IFT46 Gene

Sources for IFT46 Gene

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