IFT27 Gene
protein-coding GIFtS: 44
GCID: GC22M037154
|
|
intraflagellar transport 27 homolog (Chlamydomonas)(Previous names: RAB, member of RAS oncogene family-like 4 )
(Previous symbol: RABL4)
| |
Aliases
for IFT27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Intraflagellar Transport 27 Homolog (Chlamydomonas)1 2 | | Rab-Like Protein 42 3 | | RABL41 2 3 | | Intraflagellar Transport Protein 27 Homolog2 | | RAYL1 2 3 | | Putative GTP-Binding Protein RAY-Like3 | | RAB, Member Of RAS Oncogene Family-Like 41 2 | | |
Export aliases for IFT27 gene to outside databasesPrevious GC identifer: GC22M020117 |
Summaries
for IFT27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IFT27:
This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B.Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicingof this gene results in multiple transcript variants. (provided by RefSeq, Jan 2012)
UniProtKB/Swiss-Prot: IFT27_HUMAN, Q9BW83Function: Possesses GTPase activity (By similarity)
|
Genomic Views
for IFT27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IFT27
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFT27
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFT27 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q13.1IFT27 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M037154: view genomic region
(about GC identifiers)
Start:
|
37,154,246 bp from pter |
End:
|
37,172,300 bp from pter |
Size:
|
18,055 bases |
Orientation:
|
minus strand |
|
Proteins
for IFT27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFT27_HUMAN, Q9BW83 (See
protein sequence)Recommended Name: Intraflagellar transport protein 27 homolog Size: 186 amino acids; 20480 Da
Subunit: Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 (By similarity)
Secondary accessions: O60897Alternative splicing: 2 isoforms: Q9BW83-1 Q9BW83-2 Explore the universe of human proteins at neXtProt for IFT27: NX_Q9BW83
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BW83
IFT27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001171172.1 NP_006851.1
ENSEMBL proteins: ENSP00000343593 ENSP00000404556 ENSP00000392016 ENSP00000390016 ENSP00000399606 ENSP00000393541 ENSP00000405394
Human Recombinant Protein Products for IFT27:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030992 | intraflagellar transport particle B |
ISS | -- | | GO:0031514 | motile cilium |
ISS | -- |
IFT27 for ontologies About GeneDecksing
IFT27 Antibody Products:
Assay Products for IFT27: |
Protein
Domains /
Families
for IFT27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFT27 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BW83ProtoNet protein and cluster: Q9BW83 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: IFT27_HUMAN, Q9BW83Similarity: Belongs to the small GTPase superfamily. Ras family |
Function
for IFT27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IFT27_HUMAN, Q9BW83Function: Possesses GTPase activity (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005525 | GTP binding |
IEA | -- |
IFT27 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFT27 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFT27 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for IFT27 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFT27 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFT27 |
|
Pathways & Interactions
for IFT27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFT27
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/12 Interacting proteins for IFT27 (Q9BW832, 3 ENSP000003435934) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
IFT27 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFT27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFT27
Search CenterWatch for drugs/clinical trials and news about IFT27
|
Transcripts
for IFT27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFT27 gene (3 alternative transcripts): NM_001177701.2 NM_006860.4 NM_001177702.1 Unigene Cluster for IFT27: Intraflagellar transport 27 homolog (Chlamydomonas) Hs.415172 [show with all ESTs]Unigene Representative Sequence: NM_00117770113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340630(uc003apu.2) ENST00000495987 ENST00000474616 ENST00000495555
ENST00000415653 ENST00000471809(uc003apw.2) ENST00000417951 ENST00000430701
ENST00000440696 ENST00000465023 ENST00000476548(uc021wop.1) ENST00000433985(uc003apv.2 uc010gwy.2)
ENST00000453009(uc021won.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFT27 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFT27 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AK307105.1 AK307382.1 AL022729.1 BC000566.2 BT006815.1 CR456558.1 NR_033531.2 9 DOTS entries: DT.444096 DT.75170537 DT.214480 DT.40270584 DT.75100627 DT.97843040 DT.429233 DT.95197747 DT.120670660 24/126 AceView cDNA sequences (see all 126): AL037166 BM980301 BQ010908 CR456558 BM716011 AA809074 BU739001 BF174985 AI572109 AI990070 BX098261 AW236857 AI334224 AI200910 BM973046 AI299024 AA258131 AI372083 BQ949759 BE551990 AI080758 BI520166 AI057621 BU687112
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IFT27 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 |
|---|
|
| SP1: | | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IFT27
|
Expression
for IFT27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFT27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGAGCTGGA
About this image
See IFT27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFT27
SOURCE GeneReport for Unigene cluster: Hs.415172
SABiosciences Custom PCR Arrays for IFT27
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFT27
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFT27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFT27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFT27 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFT27 |
Orthologs
for IFT27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFT27 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ift271 , 5 |
intraflagellar transport 27 homolog (Chlamydomonas)5
intraflagellar transport 271 |
85.23(n)1
83.78(a)1 |
|
15 (36.92 cM)5
670421 NM_025931.21 NP_080207.11
781594655 |
chicken
(Gallus gallus) |
Aves |
IFT271 |
intraflagellar transport 27 homolog (Chlamydomonas) |
72.22(n)
73.66(a) |
|
418053 XM_001234617.2 XP_001234618.1 |
lizard
(Anolis carolinensis) |
Reptilia |
IFT276 |
-- |
67(a) |
1 ↔ 1 |
5(22487918-22491211) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.253752 |
Xenopus laevis transcribed sequence with weak similarity more |
76.6(n) |
|
AW635217.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ift271 |
intraflagellar transport 27 homolog (Chlamydomonas) |
61.99(n)
55.62(a) |
|
494045 NM_001008588.1 NP_001008588.1 |
ENSEMBL Gene Tree for IFT27 (if available)
TreeFam Gene Tree for IFT27 (if available) |
Paralogs
for IFT27 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IFT27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFT27 (37154246 - 37172300 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFT27: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFT27 |
|
Disorders
/ Diseases
for IFT27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for IFT27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFT27 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with IFT27) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2, 3 Collins J.E.... Dunham I. (2003)
- Intraflagellar transport protein 27 is a small G prot ein involved in cell-cycle control. (PubMed id 17276912)1, 3 Qin H....Rosenbaum J. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Thousands of rab GTPases for the cell biologist. (PubMed id 22022256)1 Diekmann Y....Pereira-Leal J.B. (2011)
- A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for IFT27 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFT27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFT27 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFT27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFT27 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IFT27 gene:
Search GeneIP for patents involving IFT27
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFT27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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