Aliases for IFT27 Gene
External Ids for IFT27 Gene
Previous HGNC Symbols for IFT27 Gene
Previous GeneCards Identifiers for IFT27 Gene
This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for IFT27 Gene
IFT27 (Intraflagellar Transport 27) is a Protein Coding gene. Diseases associated with IFT27 include Bardet-Biedl Syndrome 19 and Ift27-Related Bardet-Biedl Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. GO annotations related to this gene include GTP binding and GTPase activity.
UniProtKB/Swiss-Prot for IFT27 Gene
Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25 (By similarity).