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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFT27 Gene

protein-coding   GIFtS: 44
GCID: GC22M037154

Intraflagellar Transport 27 Homolog (Chlamydomonas)

(Previous names: RAB, member of RAS oncogene family-like 4)
(Previous symbol: RABL4)
  Search for IFT27
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Intraflagellar Transport 27 Homolog (Chlamydomonas)1 2     RAYL2 3
RABL41 2 3     Intraflagellar Transport Protein 27 Homolog2
RAB, Member Of RAS Oncogene Family-Like 41 2     Putative GTP-Binding Protein RAY-Like3
Rab-Like Protein 42 3     

External Ids:    HGNC: 186261   Entrez Gene: 110202   Ensembl: ENSG000001003607   UniProtKB: Q9BW833   

Export aliases for IFT27 gene to outside databases

Previous GC identifer: GC22M020117


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFT27 Gene:
This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B.
Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative
splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for IFT27 Gene: 
IFT27 (intraflagellar transport 27 homolog (Chlamydomonas)) is a protein-coding gene. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot: IFT27_HUMAN, Q9BW83
Function: Possesses GTPase activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IFT27
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFT27 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFT27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFT27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

IFT27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFT27 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037154:  view genomic region     (about GC identifiers)

Start:
37,154,246 bp from pter      End:
37,172,300 bp from pter
Size:
18,055 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFT27_HUMAN, Q9BW83 (See protein sequence)
Recommended Name: Intraflagellar transport protein 27 homolog  
Size: 186 amino acids; 20480 Da
Subunit: Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 (By
similarity)
Secondary accessions: O60897
Alternative splicing: 2 isoforms:  Q9BW83-1   Q9BW83-2   

Explore the universe of human proteins at neXtProt for IFT27: NX_Q9BW83

Explore proteomics data for IFT27 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BW83

  • IFT27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFT27 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171172.1  NP_006851.1  

    ENSEMBL proteins: 
     ENSP00000343593   ENSP00000404556   ENSP00000392016   ENSP00000390016   ENSP00000399606  
     ENSP00000393541   ENSP00000405394  

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    Cloud-Clone Corp. Proteins for IFT27 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0016020membrane ----
    GO:0030992intraflagellar transport particle B ISS--
    GO:0031514motile cilium ISS--

    IFT27 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFT: Intraflagellar transport homologs

    3 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9BW83

    ProtoNet protein and cluster: Q9BW83

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: IFT27_HUMAN, Q9BW83
    Similarity: Belongs to the small GTPase superfamily. Ras family


    IFT27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFT27_HUMAN, Q9BW83
    Function: Possesses GTPase activity (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
         
    IFT27 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFT27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/12 Interacting proteins for IFT27 (Q9BW832, 3 ENSP000003435934) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPB11Q9Y5472, 3, ENSP000001942144MINT-66983 I2D: score=5 STRING: ENSP00000194214
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    CSNK1EP496743I2D: score=1 
    GSK3BP498413I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    IFT27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFT27

    Search CenterWatch for drugs/clinical trials and news about IFT27

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFT27 gene (3 alternative transcripts): 
    NM_001177701.2  NM_006860.4  NM_001177702.1  

    Unigene Cluster for IFT27:

    Intraflagellar transport 27 homolog (Chlamydomonas)
    Hs.415172  [show with all ESTs]
    Unigene Representative Sequence: NM_001177701
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340630(uc003apu.2) ENST00000495987 ENST00000474616 ENST00000495555
    ENST00000415653 ENST00000471809(uc003apw.2) ENST00000417951 ENST00000430701
    ENST00000440696 ENST00000465023 ENST00000476548(uc021wop.1) ENST00000433985(uc003apv.2 uc010gwy.2)
    ENST00000453009(uc021won.1)
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    Additional mRNA sequence: 

    AK307105.1 AK307382.1 AL022729.1 BC000566.2 BT006815.1 CR456558.1 NR_033531.2 

    9 DOTS entries:

    DT.444096  DT.75170537  DT.214480  DT.40270584  DT.75100627  DT.97843040  DT.429233  DT.95197747 
    DT.120670660 

    24/126 AceView cDNA sequences (see all 126):

    BM713693 H55219 AI080758 BU732669 BQ949759 AW236857 BE350217 AL040362 
    CB853127 AI990070 BM973046 AA258131 BU733554 AL037166 C02284 AA676431 
    BQ010908 AI372083 BC000566 AI299024 BM711121 BX098261 CR456558 CB852345 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IFT27 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
    SP1:        -           -     -                 -                                       
    SP2:                    -     -                 -                                       
    SP3:                    -     -                 -                                       
    SP4:                                            -                                       
    SP5:                    -     -                 -                                       


    ECgene alternative splicing isoforms for IFT27

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFT27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGAGCTGGA
    IFT27 Expression
    About this image


    See IFT27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFT27

    SOURCE GeneReport for Unigene cluster: Hs.415172
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFT27 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ift271 , 5 intraflagellar transport 27 homolog (Chlamydomonas)5
    intraflagellar transport 271
    85.23(n)1
    83.78(a)1
      15 (36.92 cM)5
    670421  NM_025931.21  NP_080207.11 
     781594655 
    chicken
    (Gallus gallus)
    Aves IFT271 intraflagellar transport 27 homolog (Chlamydomonas) 72.22(n)
    73.66(a)
      418053  XM_001234617.2  XP_001234618.1 
    lizard
    (Anolis carolinensis)
    Reptilia IFT276
    intraflagellar transport 27 homolog (Chlamydomonas...
    69(a)
    1 ↔ 1
    5(22485271-22498149)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253752 Xenopus laevis transcribed sequence with weak similarity more 76.6(n)    AW635217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ift271 intraflagellar transport 27 homolog (Chlamydomonas) 61.99(n)
    55.62(a)
      494045  NM_001008588.1  NP_001008588.1 


    ENSEMBL Gene Tree for IFT27 (if available)
    TreeFam Gene Tree for IFT27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFT27 gene
    18/43 SIMAP similar genes for IFT27 using alignment to 6 protein entries:     IFT27_HUMAN (see all proteins) (see all similar genes):
    RAB30    RAB12    RAB19    RAB41    RAB6B    RAB43
    RAB5C    RAB11A    RAB10    RAB1B    RALB    RAB1C
    RAB6A    RAB13    RAB2B    RAB44    RAB8B    RAB6C

    IFT27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/425 SNPs in IFT27 are shown (see all 425)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432704941,2
    --37153933(+) CCCATC/TTCAGC 2 -- ds50010--------
    rs1874134451,2
    --37154048(+) AGGCCC/TTTTAA 2 -- ds50010--------
    rs1483300591,2
    --37154075(+) GCCGCA/GCAGTG 2 -- ds50010--------
    rs785444381,2
    C,F--37154291(+) CATTAT/CATATT 2 -- ut311Minor allele frequency- C:0.03WA 118
    rs2015341291,2
    --37154326(+) TCTCCA/GGTTGT 2 -- ut310--------
    rs2003498281,2
    C--37154339(+) AGCACA/GATCTG 2 -- ut310--------
    rs1404400231,2
    C--37154368(+) GGGCCC/TGGAAA 4 Q R mis11Minor allele frequency- T:0.00NA 4552
    rs1450665421,2
    C--37154406(+) TGGAAC/TTGCTT 4 Q syn11Minor allele frequency- T:0.00NA 4552
    rs1180957261,2
    C,F--37154413(+) GCTTGG/ACAAGG 4 /A /V mis11Minor allele frequency- A:0.00NA 4552
    rs1431445621,2
    C,F--37154436(+) GCTTCG/AAAGTT 4 /F syn12Minor allele frequency- A:0.00NA EU 5871

    HapMap Linkage Disequilibrium report for IFT27 (37154246 - 37172300 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IFT27:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3618CNV Insertion18451855
    nsv3617CNV Loss18451855
    nsv511077CNV Complex20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFT27 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with IFT27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2, 3 Collins J.E.... Dunham I. (2003)
    2. Intraflagellar transport protein 27 is a small G prot ein involved in cell-cycle control. (PubMed id 17276912)1, 3 Qin H....Rosenbaum J. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Thousands of rab GTPases for the cell biologist. (PubMed id 22022256)1 Diekmann Y....Pereira-Leal J.B. (2011)
    9. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11020 HGNC: 18626 AceView: RABL4 Ensembl:ENSG00000100360 euGenes: HUgn11020
    ECgene: IFT27 H-InvDB: IFT27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFT27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFT27 gene:
    Search GeneIP for patents involving IFT27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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