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IFT27 Gene

protein-coding   GIFtS: 45
GCID: GC22M037154

Intraflagellar Transport 27 Homolog (Chlamydomonas)

(Previous names: RAB, member of RAS oncogene family-like 4)
(Previous symbol: RABL4)
  See IFT27-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Intraflagellar Transport 27 Homolog (Chlamydomonas)1 2     RAYL2 3
RABL41 2 3     BBS192
RAB, Member Of RAS Oncogene Family-Like 41 2     Intraflagellar Transport Protein 27 Homolog2
Rab-Like Protein 42 3     Putative GTP-Binding Protein RAY-Like3

External Ids:    HGNC: 186261   Entrez Gene: 110202   Ensembl: ENSG000001003607   UniProtKB: Q9BW833   
ORGUL members:         

Export aliases for IFT27 gene to outside databases

Previous GC identifer: GC22M020117


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFT27 Gene:
This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B.
Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative
splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for IFT27 Gene:
IFT27 (intraflagellar transport 27 homolog (Chlamydomonas)) is a protein-coding gene. Diseases associated with IFT27 include bardet-biedl syndrome 19, and bardet-biedl syndrome, modifier of. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot: IFT27_HUMAN, Q9BW83
Function: Small GTPase-like component of the intraflagellar transport (IFT) complex B. Forms a subcomplex within
the IFT complex B with IFT25 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IFT27
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFT27 promoter sequence
   Search Chromatin IP Primers for IFT27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFT27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

IFT27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFT27 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037154:  view genomic region     (about GC identifiers)

Start:
37,154,246 bp from pter      End:
37,172,300 bp from pter
Size:
18,055 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IFT27_HUMAN, Q9BW83 (See protein sequence)
Recommended Name: Intraflagellar transport protein 27 homolog  
Size: 186 amino acids; 20480 Da
Subunit: Component of the IFT complex B, at least composed of IFT20, IFT25/HSPB11, IFT27, IFT52, IFT57, IFT74,
IFT81, IFT88 and TRAF3IP1. Interacts with IFT25; the interaction is direct. Interacts with RABL2/RABL2A; binding
is equal in the presence of GTP or GDP (By similarity)
Secondary accessions: O60897
Alternative splicing: 2 isoforms:  Q9BW83-1   Q9BW83-2   

Explore the universe of human proteins at neXtProt for IFT27: NX_Q9BW83

Explore proteomics data for IFT27 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFT27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171172.1  NP_006851.1  

    ENSEMBL proteins: 
     ENSP00000343593   ENSP00000404556   ENSP00000392016   ENSP00000390016   ENSP00000399606  
     ENSP00000393541   ENSP00000405394  

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    antibodies-online proteins for IFT27 (4 products) 

     
    antibodies-online peptides for IFT27

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    antibodies-online antibodies for IFT27 (14 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene
    IFT: Intraflagellar transport homologs

    3 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9BW83

    ProtoNet protein and cluster: Q9BW83

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: IFT27_HUMAN, Q9BW83
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with IFT27           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFT27_HUMAN, Q9BW83
    Function: Small GTPase-like component of the intraflagellar transport (IFT) complex B. Forms a subcomplex within
    the IFT complex B with IFT25 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with IFT27           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IFT27

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0016020membrane ----
    GO:0030992intraciliary transport particle B ISS--
    GO:0031514motile cilium ISS--

    Find genes that share ontologies with IFT27           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IFT27
    Interactions:

        Search GeneGlobe Interaction Network for IFT27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for IFT27 (Q9BW832, 3 ENSP000003435934) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPB11Q9Y5472, 3, ENSP000001942144MINT-66983 I2D: score=5 STRING: ENSP00000194214
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    CSNK1EP496743I2D: score=1 
    GSK3BP498413I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    Find genes that share ontologies with IFT27           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFT27



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFT27 gene (3 alternative transcripts): 
    NM_001177701.2  NM_006860.4  NM_001177702.1  

    Unigene Cluster for IFT27:

    Intraflagellar transport 27 homolog (Chlamydomonas)
    Hs.415172  [show with all ESTs]
    Unigene Representative Sequence: NM_001177701
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340630(uc003apu.2) ENST00000495987 ENST00000474616 ENST00000495555
    ENST00000415653 ENST00000471809(uc003apw.2) ENST00000417951 ENST00000430701
    ENST00000440696 ENST00000465023 ENST00000476548(uc021wop.1) ENST00000433985(uc003apv.2 uc010gwy.2)
    ENST00000453009(uc021won.1)
    miRNA
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    Additional mRNA sequence: 

    AK307105.1 AK307382.1 AL022729.1 BC000566.2 BT006815.1 CR456558.1 NR_033531.2 

    9 DOTS entries:

    DT.444096  DT.75170537  DT.214480  DT.40270584  DT.75100627  DT.97843040  DT.429233  DT.95197747 
    DT.120670660 

    Selected AceView cDNA sequences (see all 126):

    AI572109 AL040362 CB853127 AI299024 NM_006860 AL037166 BI520166 AI080758 
    BE350217 BU732669 BM713693 AA676431 AA258131 AI057621 BM973046 C02284 
    BU733554 BM716011 BU687112 AI334224 CR456558 AI696240 BQ010908 AI200910 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IFT27 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
    SP1:        -           -     -                 -                                       
    SP2:                    -     -                 -                                       
    SP3:                    -     -                 -                                       
    SP4:                                            -                                       
    SP5:                    -     -                 -                                       


    ECgene alternative splicing isoforms for IFT27

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFT27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGAGCTGGA
    IFT27 Expression
    About this image


    IFT27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    IFT27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFT27 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.415172
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFT27 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ift271 , 5 intraflagellar transport 27 homolog (Chlamydomonas)5
    intraflagellar transport 271
    84.95(n)1
    83.33(a)1
      15 (36.92 cM)5
    670421  NM_025931.21  NP_080207.11 
     781594655 
    chicken
    (Gallus gallus)
    Aves IFT271 intraflagellar transport 27 homolog (Chlamydomonas) 72.22(n)
    73.66(a)
      418053  NM_001277380.1  NP_001264309.1 
    lizard
    (Anolis carolinensis)
    Reptilia IFT276
    intraflagellar transport 27 homolog (Chlamydomonas...
    69(a)
    1 ↔ 1
    5(22485271-22498149)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253752 Xenopus laevis transcribed sequence with weak similarity more 76.6(n)    AW635217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ift271 intraflagellar transport 27 homolog (Chlamydomonas) 61.99(n)
    55.62(a)
      494045  NM_001008588.1  NP_001008588.1 


    ENSEMBL Gene Tree for IFT27 (if available)
    TreeFam Gene Tree for IFT27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFT27 gene
    Selected SIMAP similar genes for IFT27 using alignment to 6 protein entries:     IFT27_HUMAN (see all proteins) (see all similar genes):
    RAB30    RAB12    RAB19    RAB41    RAB6B    RAB43
    RAB5C    RAB11A    RAB10    RAB1B    RALB    RAB1C
    RAB6A    RAB13    RAB2B    RAB44    RAB8B    RAB6C

    Find genes that share paralogs with IFT27           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFT27 (see all 425)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432704941,2
    --37153933(+) CCCATC/TTCAGC 2 -- ds50010--------
    rs1874134451,2
    --37154048(+) AGGCCC/TTTTAA 2 -- ds50010--------
    rs1483300591,2
    --37154075(+) GCCGCA/GCAGTG 2 -- ds50010--------
    rs785444381,2
    C,F--37154291(+) CATTAT/CATATT 2 -- ut311Minor allele frequency- C:0.03WA 118
    rs2015341291,2
    --37154326(+) TCTCCA/GGTTGT 2 -- ut310--------
    rs2003498281,2
    C--37154339(+) AGCACA/GATCTG 2 -- ut310--------
    rs1404400231,2
    C--37154368(+) GGGCCC/TGGAAA 4 Q R mis11Minor allele frequency- T:0.00NA 4552
    rs1450665421,2
    C--37154406(+) TGGAAC/TTGCTT 4 Q syn11Minor allele frequency- T:0.00NA 4552
    rs1180957261,2
    C,F--37154413(+) GCTTGG/ACAAGG 4 /A /V mis11Minor allele frequency- A:0.00NA 4552
    rs1431445621,2
    C,F--37154436(+) GCTTCG/AAAGTT 4 /F syn12Minor allele frequency- A:0.00NA EU 5871

    HapMap Linkage Disequilibrium report for IFT27 (37154246 - 37172300 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IFT27:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3618CNV Insertion18451855
    nsv3617CNV Loss18451855
    nsv511077CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IFT27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for IFT27:    
    About MalaCards
    bardet-biedl syndrome 19    bardet-biedl syndrome, modifier of


    Find genes that share disorders with IFT27           About GenesLikeMe


    Export disorders for IFT27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFT27 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with IFT27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2, 3 Collins J.E.... Dunham I. (Genome Res. 2003)
    2. Intraflagellar transport protein 27 is a small G protein involved in cell-cycle control. (PubMed id 17276912)1, 3 Qin H....Rosenbaum J. (Curr. Biol. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Thousands of rab GTPases for the cell biologist. (PubMed id 22022256)1 Diekmann Y....Pereira-Leal J.B. (PLoS Comput. Biol. 2011)
    10. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11020 HGNC: 18626 AceView: RABL4 Ensembl:ENSG00000100360 euGenes: HUgn11020
    ECgene: IFT27 H-InvDB: IFT27

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFT27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFT27 gene:
    Search GeneIP for patents involving IFT27

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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