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Aliases for IFT22 Gene

Aliases for IFT22 Gene

  • Intraflagellar Transport 22 2 3 5
  • RAB, Member RAS Oncogene Family-Like 5 2 3
  • Rab-Like Protein 5 3 4
  • RABL5 3 4
  • Intraflagellar Transport 22 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport Protein 22 Homolog 3
  • RAB, Member Of RAS Oncogene Family-Like 5 3
  • Intraflagellar Transport 22 Homolog 3

External Ids for IFT22 Gene

Previous HGNC Symbols for IFT22 Gene

  • RABL5

Previous GeneCards Identifiers for IFT22 Gene

  • GC07M100961

Summaries for IFT22 Gene

GeneCards Summary for IFT22 Gene

IFT22 (Intraflagellar Transport 22) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for IFT22 Gene

  • Small GTPase-like component of the intraflagellar transport (IFT) complex B.

Additional gene information for IFT22 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFT22 Gene

Genomics for IFT22 Gene

GeneHancer (GH) Regulatory Elements for IFT22 Gene

Promoters and enhancers for IFT22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I101321 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.1 -124 1.6 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ETS1 ZNF121 IFT22 LOC101927746 SRRT PCOLCE-AS1 MEPCE GIGYF1 COL26A1
GH07I101319 Promoter 0.5 EPDnew 550.8 +2.7 2744 0.1 IFT22 PIR42767 LOC101927746
GH07I100581 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +737.2 737156 5.9 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 ZNF610 FBXO24 LRCH4 ZSCAN25 AP4M1 ZSCAN21 SRRT SAP25 MEPCE PPP1R35 GIGYF1
GH07I101879 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -561.0 -561021 6.3 PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 FAM185A IFT22 ENSG00000213385 CUX1 SH2B2 GC07P101859 ENSG00000272219
GH07I101352 Enhancer 1 ENCODE 0.3 -30.7 -30732 0.3 PKNOX1 ATF1 FOXA2 ARNT ARID4B SIN3A YY1 TCF12 ZNF766 GATA2 LOC101927746 COL26A1 IFT22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFT22 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IFT22 Gene

Genomic Locations for IFT22 Gene
8,457 bases
Minus strand

Genomic View for IFT22 Gene

Genes around IFT22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFT22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFT22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFT22 Gene

Proteins for IFT22 Gene

  • Protein details for IFT22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intraflagellar transport protein 22 homolog
    Protein Accession:
    Secondary Accessions:
    • Q49AG1
    • Q69YV5
    • Q9BSW4

    Protein attributes for IFT22 Gene

    185 amino acids
    Molecular mass:
    20835 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).

    Alternative splice isoforms for IFT22 Gene


neXtProt entry for IFT22 Gene

Post-translational modifications for IFT22 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IFT22 Gene

Domains & Families for IFT22 Gene

Gene Families for IFT22 Gene

Protein Domains for IFT22 Gene


Suggested Antigen Peptide Sequences for IFT22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with IFT22: view

Function for IFT22 Gene

Molecular function for IFT22 Gene

UniProtKB/Swiss-Prot Function:
Small GTPase-like component of the intraflagellar transport (IFT) complex B.

Gene Ontology (GO) - Molecular Function for IFT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with IFT22: view

Phenotypes for IFT22 Gene

genes like me logo Genes that share phenotypes with IFT22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFT22 Gene

Localization for IFT22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFT22 Gene

Cell projection, cilium.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFT22 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IFT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IEA --
GO:0005929 cilium TAS --
GO:0030992 intraciliary transport particle B ISS --
GO:0042995 cell projection IEA --
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with IFT22: view

Pathways & Interactions for IFT22 Gene

genes like me logo Genes that share pathways with IFT22: view

Pathways by source for IFT22 Gene

Gene Ontology (GO) - Biological Process for IFT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035735 intraciliary transport involved in cilium assembly TAS --
genes like me logo Genes that share ontologies with IFT22: view

No data available for SIGNOR curated interactions for IFT22 Gene

Drugs & Compounds for IFT22 Gene

No Compound Related Data Available

Transcripts for IFT22 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFT22 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - -

Relevant External Links for IFT22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFT22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFT22 Gene

Protein differential expression in normal tissues from HIPED for IFT22 Gene

This gene is overexpressed in Bone (59.6) and Ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IFT22 Gene

Protein tissue co-expression partners for IFT22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IFT22 Gene:


Evidence on tissue expression from TISSUES for IFT22 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with IFT22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFT22 Gene

Orthologs for IFT22 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFT22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RABL5 34 33
  • 99.82 (n)
(Canis familiaris)
Mammalia RABL5 34 33
  • 88.47 (n)
(Monodelphis domestica)
Mammalia RABL5 34
  • 88 (a)
(Bos Taurus)
Mammalia RABL5 34 33
  • 87.93 (n)
(Ornithorhynchus anatinus)
Mammalia RABL5 34
  • 87 (a)
(Mus musculus)
Mammalia Rabl5 34 33
  • 86.85 (n)
Ift22 16
(Rattus norvegicus)
Mammalia Rabl5 33
  • 85.95 (n)
(Gallus gallus)
Aves RABL5 34 33
  • 69.55 (n)
(Anolis carolinensis)
Reptilia RABL5 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rabl5 33
  • 67.22 (n)
Str.15879 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4597 33
(Danio rerio)
Actinopterygii rabl5 34 33
  • 62.7 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9237 33
(Caenorhabditis elegans)
Secernentea ifta-2 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for IFT22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFT22 Gene

Gene Tree for IFT22 (if available)
Gene Tree for IFT22 (if available)

Paralogs for IFT22 Gene

No data available for Paralogs for IFT22 Gene

Variants for IFT22 Gene

Sequence variations from dbSNP and Humsavar for IFT22 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000320641 -- 101,314,479(-) A/G 3_prime_UTR_variant
rs1000394365 -- 101,314,772(-) C/G 3_prime_UTR_variant
rs1000400338 -- 101,319,221(-) G/C intron_variant
rs1000628953 -- 101,313,620(-) C/G 3_prime_UTR_variant
rs1001149101 -- 101,323,164(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFT22 Gene

Variant ID Type Subtype PubMed ID
dgv236e55 CNV gain 17911159
dgv6537n100 CNV gain 25217958
esv2422326 CNV duplication 17116639
esv2422376 CNV duplication 17116639
esv2669069 CNV deletion 23128226
esv2752134 CNV gain 17911159
esv3614327 CNV loss 21293372
nsv1023393 CNV gain 25217958
nsv1030604 CNV gain 25217958
nsv517175 CNV gain+loss 19592680
nsv607974 CNV loss 21841781
nsv607978 CNV loss 21841781
nsv831076 CNV loss 17160897
nsv831077 CNV loss 17160897

Variation tolerance for IFT22 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFT22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFT22 Gene

Disorders for IFT22 Gene

Additional Disease Information for IFT22

No disorders were found for IFT22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFT22 Gene

Publications for IFT22 Gene

  1. The RABL5 homolog IFT22 regulates the cellular pool size and the amount of IFT particles partitioned to the flagellar compartment in Chlamydomonas reinhardtii. (PMID: 22076686) Silva DA … Qin H (Cytoskeleton (Hoboken, N.J.) 2012) 2 3 58
  2. A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum. (PMID: 19240117) Adhiambo C … Bastin P (Journal of cell science 2009) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for IFT22 Gene

Sources for IFT22 Gene

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