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Aliases for IFT22 Gene

Aliases for IFT22 Gene

  • Intraflagellar Transport 22 2 3 5
  • RAB, Member RAS Oncogene Family-Like 5 2 3
  • Rab-Like Protein 5 3 4
  • RABL5 3 4
  • Intraflagellar Transport 22 Homolog (Chlamydomonas) 2
  • RAB, Member Of RAS Oncogene Family-Like 5 3
  • Intraflagellar Transport 22 Homolog 3

External Ids for IFT22 Gene

Previous HGNC Symbols for IFT22 Gene

  • RABL5

Previous GeneCards Identifiers for IFT22 Gene

  • GC07M100961

Summaries for IFT22 Gene

GeneCards Summary for IFT22 Gene

IFT22 (Intraflagellar Transport 22) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for IFT22 Gene

  • Small GTPase-like component of the intraflagellar transport (IFT) complex B.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFT22 Gene

Genomics for IFT22 Gene

Regulatory Elements for IFT22 Gene

Enhancers for IFT22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFT22 on UCSC Golden Path with GeneCards custom track

Promoters for IFT22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IFT22 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFT22 Gene

101,313,367 bp from pter
101,321,823 bp from pter
8,457 bases
Minus strand

Genomic View for IFT22 Gene

Genes around IFT22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFT22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFT22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFT22 Gene

Proteins for IFT22 Gene

  • Protein details for IFT22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intraflagellar transport protein 22 homolog
    Protein Accession:
    Secondary Accessions:
    • Q49AG1
    • Q69YV5
    • Q9BSW4

    Protein attributes for IFT22 Gene

    185 amino acids
    Molecular mass:
    20835 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).

    Alternative splice isoforms for IFT22 Gene


neXtProt entry for IFT22 Gene

Proteomics data for IFT22 Gene at MOPED

Post-translational modifications for IFT22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFT22 Gene

Domains & Families for IFT22 Gene

Protein Domains for IFT22 Gene


Suggested Antigen Peptide Sequences for IFT22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with IFT22: view

Function for IFT22 Gene

Molecular function for IFT22 Gene

UniProtKB/Swiss-Prot Function:
Small GTPase-like component of the intraflagellar transport (IFT) complex B.

Phenotypes for IFT22 Gene

genes like me logo Genes that share phenotypes with IFT22: view

Animal Model Products

miRNA for IFT22 Gene

miRTarBase miRNAs that target IFT22

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFT22 Gene

Localization for IFT22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFT22 Gene

Cell projection, cilium.

Gene Ontology (GO) - Cellular Components for IFT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IEA --
GO:0030992 intraciliary transport particle B ISS --
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with IFT22: view

No data available for Subcellular locations from COMPARTMENTS for IFT22 Gene

Pathways & Interactions for IFT22 Gene

genes like me logo Genes that share pathways with IFT22: view

Pathways by source for IFT22 Gene

Interacting Proteins for IFT22 Gene

Gene Ontology (GO) - Biological Process for IFT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with IFT22: view

No data available for SIGNOR curated interactions for IFT22 Gene

Drugs & Compounds for IFT22 Gene

No Compound Related Data Available

Transcripts for IFT22 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IFT22 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - -

Relevant External Links for IFT22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFT22 Gene

mRNA expression in normal human tissues for IFT22 Gene

Protein differential expression in normal tissues from HIPED for IFT22 Gene

This gene is overexpressed in Bone (59.6) and Ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFT22 Gene

genes like me logo Genes that share expression patterns with IFT22: view

Protein tissue co-expression partners for IFT22 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFT22 Gene

Orthologs for IFT22 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFT22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RABL5 35
  • 87.93 (n)
  • 89.73 (a)
RABL5 36
  • 90 (a)
(Canis familiaris)
Mammalia RABL5 35
  • 88.47 (n)
  • 89.73 (a)
RABL5 36
  • 68 (a)
(Mus musculus)
Mammalia Rabl5 35
  • 86.85 (n)
  • 90.27 (a)
Ift22 16
Rabl5 36
  • 90 (a)
(Pan troglodytes)
Mammalia RABL5 35
  • 99.82 (n)
  • 100 (a)
RABL5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rabl5 35
  • 85.95 (n)
  • 90.27 (a)
(Monodelphis domestica)
Mammalia RABL5 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia RABL5 36
  • 87 (a)
(Gallus gallus)
Aves RABL5 35
  • 69.55 (n)
  • 68.11 (a)
RABL5 36
  • 65 (a)
(Anolis carolinensis)
Reptilia RABL5 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rabl5 35
  • 67.22 (n)
  • 67.03 (a)
Str.15879 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4597 35
(Danio rerio)
Actinopterygii rabl5 35
  • 62.7 (n)
  • 61.08 (a)
rabl5 36
  • 60 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9237 35
(Caenorhabditis elegans)
Secernentea ifta-2 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for IFT22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFT22 Gene

Gene Tree for IFT22 (if available)
Gene Tree for IFT22 (if available)

Paralogs for IFT22 Gene

No data available for Paralogs for IFT22 Gene

Variants for IFT22 Gene

Sequence variations from dbSNP and Humsavar for IFT22 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs13234919 -- 101,323,091(+) ctccc(A/G)ggttc upstream-variant-2KB
rs34541954 -- 101,322,040(+) CGATC(C/T)TTCTG upstream-variant-2KB
rs34697619 -- 101,322,057(+) CTCCC(-/C/G)GAGTA upstream-variant-2KB
rs2410818 -- 101,323,290(+) CTGAG(C/T)CACTG upstream-variant-2KB
rs2410819 -- 101,323,297(+) actga(A/T)cccAC upstream-variant-2KB

Variation tolerance for IFT22 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for IFT22 Gene

Disorders for IFT22 Gene

Relevant External Links for IFT22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IFT22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFT22 Gene

Publications for IFT22 Gene

  1. The RABL5 homolog IFT22 regulates the cellular pool size and the amount of IFT particles partitioned to the flagellar compartment in Chlamydomonas reinhardtii. (PMID: 22076686) Silva D.A. … Qin H. (Cytoskeleton (Hoboken) 2012) 2 3 67
  2. A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum. (PMID: 19240117) Adhiambo C. … Bastin P. (J. Cell. Sci. 2009) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for IFT22 Gene

Sources for IFT22 Gene