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Aliases for IFT22 Gene

Aliases for IFT22 Gene

  • Intraflagellar Transport 22 2 3
  • RAB, Member RAS Oncogene Family-Like 5 2 3
  • Rab-Like Protein 5 3 4
  • RABL5 3 4
  • Intraflagellar Transport 22 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport Protein 22 Homolog 3
  • RAB, Member Of RAS Oncogene Family-Like 5 3
  • Intraflagellar Transport 22 Homolog 3

External Ids for IFT22 Gene

Previous HGNC Symbols for IFT22 Gene

  • RABL5

Previous GeneCards Identifiers for IFT22 Gene

  • GC07M100961

Summaries for IFT22 Gene

GeneCards Summary for IFT22 Gene

IFT22 (Intraflagellar Transport 22) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IFT22 Gene

  • Small GTPase-like component of the intraflagellar transport (IFT) complex B.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFT22 Gene

Genomics for IFT22 Gene

Genomic Location for IFT22 Gene

Start:
101,313,367 bp from pter
End:
101,321,823 bp from pter
Size:
8,457 bases
Orientation:
Minus strand

Genomic View for IFT22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFT22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFT22 Gene

No data available for Regulatory Elements for IFT22 Gene

Proteins for IFT22 Gene

  • Protein details for IFT22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7X7-IFT22_HUMAN
    Recommended name:
    Intraflagellar transport protein 22 homolog
    Protein Accession:
    Q9H7X7
    Secondary Accessions:
    • Q49AG1
    • Q69YV5
    • Q9BSW4

    Protein attributes for IFT22 Gene

    Size:
    185 amino acids
    Molecular mass:
    20835 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).

    Alternative splice isoforms for IFT22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFT22 Gene

Proteomics data for IFT22 Gene at MOPED

Post-translational modifications for IFT22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFT22 Gene

Domains for IFT22 Gene

Gene Families for IFT22 Gene

HGNC:
  • IFT :Intraflagellar transport homologs

Protein Domains for IFT22 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H7X7

UniProtKB/Swiss-Prot:

IFT22_HUMAN :
  • Q9H7X7
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with IFT22: view

No data available for Suggested Antigen Peptide Sequences for IFT22 Gene

Function for IFT22 Gene

Molecular function for IFT22 Gene

UniProtKB/Swiss-Prot Function: Small GTPase-like component of the intraflagellar transport (IFT) complex B.

Gene Ontology (GO) - Molecular Function for IFT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with IFT22: view

Phenotypes for IFT22 Gene

GenomeRNAi human phenotypes for IFT22:
genes like me logo Genes that share phenotypes with IFT22: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFT22 Gene

Localization for IFT22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFT22 Gene

Cell projection, cilium.

Gene Ontology (GO) - Cellular Components for IFT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005813 centrosome IEA --
GO:0005929 cilium --
GO:0012505 endomembrane system IBA --
GO:0030992 intraciliary transport particle B ISS --
genes like me logo Genes that share ontologies with IFT22: view

No data available for Subcellular locations from COMPARTMENTS for IFT22 Gene

Pathways for IFT22 Gene

SuperPathways for IFT22 Gene

No Data Available

Interacting Proteins for IFT22 Gene

Gene Ontology (GO) - Biological Process for IFT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006996 organelle organization TAS --
GO:0007264 small GTPase mediated signal transduction --
GO:0008152 metabolic process IBA --
GO:0032482 Rab protein signal transduction IBA --
genes like me logo Genes that share ontologies with IFT22: view

No data available for Pathways by source for IFT22 Gene

Transcripts for IFT22 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFT22

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFT22 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - -

Relevant External Links for IFT22 Gene

GeneLoc Exon Structure for
IFT22
ECgene alternative splicing isoforms for
IFT22

Expression for IFT22 Gene

mRNA expression in normal human tissues for IFT22 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IFT22 Gene

genes like me logo Genes that share expressions with IFT22: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFT22 Gene

Orthologs for IFT22 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFT22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABL5 35
  • 99.82 (n)
  • 100 (a)
RABL5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RABL5 35
  • 87.93 (n)
  • 89.73 (a)
RABL5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RABL5 35
  • 88.47 (n)
  • 89.73 (a)
RABL5 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rabl5 35
  • 86.85 (n)
  • 90.27 (a)
Rabl5 16
Rabl5 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RABL5 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RABL5 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rabl5 35
  • 85.95 (n)
  • 90.27 (a)
chicken
(Gallus gallus)
Aves RABL5 35
  • 69.55 (n)
  • 68.11 (a)
RABL5 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RABL5 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4597 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rabl5 35
  • 67.22 (n)
  • 67.03 (a)
Str.15879 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9237 35
zebrafish
(Danio rerio)
Actinopterygii rabl5 35
  • 62.7 (n)
  • 61.08 (a)
rabl5 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ifta-2 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for IFT22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFT22 Gene

ENSEMBL:
Gene Tree for IFT22 (if available)
TreeFam:
Gene Tree for IFT22 (if available)

Paralogs for IFT22 Gene

No data available for Paralogs for IFT22 Gene

Variants for IFT22 Gene

Sequence variations from dbSNP and Humsavar for IFT22 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2410818 -- 101,323,290(+) CTGAG(C/T)CACTG upstream-variant-2KB
rs2410819 -- 101,323,297(+) actga(A/T)cccAC upstream-variant-2KB
rs3807513 -- 101,322,320(+) GCTCA(A/G)ACAGG upstream-variant-2KB
rs3807514 -- 101,322,508(+) GACCT(A/G)GGAGA upstream-variant-2KB
rs4729688 -- 101,323,126(+) ctgag(C/T)agctg upstream-variant-2KB

Relevant External Links for IFT22 Gene

HapMap Linkage Disequilibrium report
IFT22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IFT22 Gene

Disorders for IFT22 Gene

No disorders were found for IFT22 Gene.

No data available for UniProtKB/Swiss-Prot for IFT22 Gene

Publications for IFT22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum. (PMID: 19240117) Adhiambo C. … Bastin P. (J. Cell. Sci. 2009) 2 3
  4. The RABL5 homolog IFT22 regulates the cellular pool size and the amount of IFT particles partitioned to the flagellar compartment in Chlamydomonas reinhardtii. (PMID: 22076686) Silva D.A. … Qin H. (Cytoskeleton (Hoboken) 2012) 2 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for IFT22 Gene

Sources for IFT22 Gene

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