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Aliases for IFT20 Gene

Aliases for IFT20 Gene

  • Intraflagellar Transport 20 2 3
  • Intraflagellar Transport 20 Homolog (Chlamydomonas) 2
  • HIFT20 4

External Ids for IFT20 Gene

Summaries for IFT20 Gene

Entrez Gene Summary for IFT20 Gene

  • This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14.[provided by RefSeq, Jun 2012]

GeneCards Summary for IFT20 Gene

IFT20 (Intraflagellar Transport 20) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IFT20 Gene

  • Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.

Gene Wiki entry for IFT20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFT20 Gene

Genomics for IFT20 Gene

Genomic Location for IFT20 Gene

Start:
28,328,325 bp from pter
End:
28,335,489 bp from pter
Size:
7,165 bases
Orientation:
Minus strand

Genomic View for IFT20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFT20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFT20 Gene

Regulatory Elements for IFT20 Gene

Proteins for IFT20 Gene

  • Protein details for IFT20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY31-IFT20_HUMAN
    Recommended name:
    Intraflagellar transport protein 20 homolog
    Protein Accession:
    Q8IY31
    Secondary Accessions:
    • J3QL09
    • Q5GLZ2
    • Q9BUG5

    Protein attributes for IFT20 Gene

    Size:
    132 amino acids
    Molecular mass:
    15281 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts directly with IFT57 and KIF3B/Kinesin II subunit. Interacts with IFT88 (By similarity). Interacts with CEP83.

    Alternative splice isoforms for IFT20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFT20 Gene

Proteomics data for IFT20 Gene at MOPED

Post-translational modifications for IFT20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFT20 Gene

Domains for IFT20 Gene

Gene Families for IFT20 Gene

HGNC:
  • IFT :Intraflagellar transport homologs

Protein Domains for IFT20 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with IFT20: view

No data available for UniProtKB/Swiss-Prot for IFT20 Gene

Function for IFT20 Gene

Molecular function for IFT20 Gene

UniProtKB/Swiss-Prot Function: Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.

Gene Ontology (GO) - Molecular Function for IFT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002046 opsin binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with IFT20: view
genes like me logo Genes that share phenotypes with IFT20: view

Animal Models for IFT20 Gene

MGI Knock Outs for IFT20:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IFT20 Gene

Localization for IFT20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFT20 Gene

Golgi apparatus, cis-Golgi network. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFT20 Gene COMPARTMENTS Subcellular localization image for IFT20 gene
Compartment Confidence
golgi apparatus 3
cytoskeleton 2
cytosol 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for IFT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0001750 photoreceptor outer segment IEA --
GO:0005794 Golgi apparatus IBA --
GO:0005813 centrosome IDA 16775004
GO:0005814 centriole IEA --
genes like me logo Genes that share ontologies with IFT20: view

Pathways for IFT20 Gene

SuperPathways for IFT20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IFT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006996 organelle organization TAS --
GO:0007224 smoothened signaling pathway IEA --
GO:0008542 visual learning IEA --
GO:0022008 neurogenesis --
genes like me logo Genes that share ontologies with IFT20: view

No data available for Pathways by source for IFT20 Gene

Transcripts for IFT20 Gene

Unigene Clusters for IFT20 Gene

Intraflagellar transport 20 homolog (Chlamydomonas):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFT20 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - -
SP8: -
SP9:
SP10: - -

Relevant External Links for IFT20 Gene

GeneLoc Exon Structure for
IFT20
ECgene alternative splicing isoforms for
IFT20

Expression for IFT20 Gene

mRNA expression in normal human tissues for IFT20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFT20 Gene

SOURCE GeneReport for Unigene cluster for IFT20 Gene Hs.705431

mRNA Expression by UniProt/SwissProt for IFT20 Gene

Q8IY31-IFT20_HUMAN
Tissue specificity: Expressed in almost all tissues.
genes like me logo Genes that share expressions with IFT20: view

Orthologs for IFT20 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFT20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFT20 36
  • 100 (n)
  • 100 (a)
IFT20 37
  • 51 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFT20 36
  • 91.88 (n)
  • 91.03 (a)
IFT20 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFT20 36
  • 95.96 (n)
  • 100 (a)
IFT20 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ift20 36
  • 91.16 (n)
  • 98.48 (a)
Ift20 16
Ift20 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IFT20 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFT20 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ift20 36
  • 90.23 (n)
  • 94.9 (a)
chicken
(Gallus gallus)
Aves IFT20 36
  • 75.25 (n)
  • 84.09 (a)
IFT20 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398244 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ift20 36
  • 80.3 (n)
  • 87.12 (a)
Str.10741 36
zebrafish
(Danio rerio)
Actinopterygii ift20 36
  • 74.49 (n)
  • 86.36 (a)
ift20 37
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006172 36
  • 56.91 (n)
  • 44.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30441 36
  • 49.19 (n)
  • 33.87 (a)
CG30441 37
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ift-20 37
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5274 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 69 (a)
OneToOne
Species with no ortholog for IFT20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFT20 Gene

ENSEMBL:
Gene Tree for IFT20 (if available)
TreeFam:
Gene Tree for IFT20 (if available)

Paralogs for IFT20 Gene

Pseudogenes.org Pseudogenes for IFT20 Gene

genes like me logo Genes that share paralogs with IFT20: view

No data available for Paralogs for IFT20 Gene

Variants for IFT20 Gene

Sequence variations from dbSNP and Humsavar for IFT20 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4450447 -- 28,331,928(+) CACCC(A/T)CAGCT reference, missense
rs7221462 -- 28,333,454(+) GTAAT(C/T)CAAAA intron-variant
rs9896248 -- 28,331,632(+) CTAAA(A/G)ACACC intron-variant
rs9897169 -- 28,331,288(+) CTAAC(C/T)AAGCT intron-variant
rs16964224 -- 28,331,136(+) AAAGC(A/G)AGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFT20 Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680
nsv2017 CNV Insertion 18451855

Relevant External Links for IFT20 Gene

HapMap Linkage Disequilibrium report
IFT20

Disorders for IFT20 Gene

No disorders were found for IFT20 Gene.

No data available for UniProtKB/Swiss-Prot for IFT20 Gene

Publications for IFT20 Gene

  1. The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. (PMID: 16775004) Follit J.A. … Pazour G.J. (Mol. Biol. Cell 2006) 3 4 23
  2. Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PMID: 12107411) Wistow G. … Peterson K. (Mol. Vis. 2002) 3 4
  3. CCDC41 is required for ciliary vesicle docking to the mother centriole. (PMID: 23530209) Joo K. … Kim J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Cloning and characterization of the human IFT20 gene. (PMID: 14672413) Yin G. … Mao Y. (Mol. Biol. Rep. 2003) 3 4

Products for IFT20 Gene

Sources for IFT20 Gene

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