Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IFT20 Gene

protein-coding   GIFtS: 49
GCID: GC17M026655

Intraflagellar Transport 20 Homolog (Chlamydomonas)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Intraflagellar Transport 20 Homolog (Chlamydomonas)1 2
Intraflagellar Transport Protein 20 Homolog2
Intraflagellar Transport Protein IFT202
hIFT203

External Ids:    HGNC: 309891   Entrez Gene: 904102   Ensembl: ENSG000001090837   OMIM: 6143945   UniProtKB: Q8IY313   
ORGUL members:         

Export aliases for IFT20 gene to outside databases

Previous GC identifers: GC17M023680 GC17M022863


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IFT20 Gene:
This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein
forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune
signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense
loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14.(provided by
RefSeq, Jun 2012)

GeneCards Summary for IFT20 Gene:
IFT20 (intraflagellar transport 20 homolog (Chlamydomonas)) is a protein-coding gene. Diseases associated with IFT20 include retinitis pigmentosa, and retinitis.

UniProtKB/Swiss-Prot: IFT20_HUMAN, Q8IY31
Function: Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role
in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy
since it is required for trafficking of ATG16L and the expansion of the autophagic compartment

Gene Wiki entry for IFT20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the IFT20 gene promoter:
         AhR   Arnt   Max   CREB   IRF-2   PPAR-gamma1   Sox9   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFT20 promoter sequence
   Search Chromatin IP Primers for IFT20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFT20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

IFT20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFT20 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M026655:  view genomic region     (about GC identifiers)

Start:
26,655,352 bp from pter      End:
26,662,515 bp from pter
Size:
7,164 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IFT20_HUMAN, Q8IY31 (See protein sequence)
Recommended Name: Intraflagellar transport protein 20 homolog  
Size: 132 amino acids; 15281 Da
Subunit: Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11/IFT25 and IFT20.
Interacts directly with IFT57 and KIF3B/Kinesin II subunit (By similarity). Interacts with CCDC41/CEP83
Secondary accessions: J3QL09 Q5GLZ2 Q9BUG5
Alternative splicing: 4 isoforms:  Q8IY31-1   Q8IY31-2   Q8IY31-3   Q8IY31-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IFT20: NX_Q8IY31

Explore proteomics data for IFT20 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFT20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001254703.1  NP_001254704.1  NP_001254705.1  NP_001254706.1  NP_001254707.1  NP_777547.1  

    ENSEMBL proteins: 
     ENSP00000463322   ENSP00000464210   ENSP00000350570   ENSP00000378809   ENSP00000464443  
     ENSP00000463138   ENSP00000464147   ENSP00000464033   ENSP00000462163  

    IFT20 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IFT20
    OriGene Protein Over-expression Lysate for IFT20
    OriGene MassSpec for IFT20
    OriGene Custom Protein Services for IFT20
    GenScript Custom Purified and Recombinant Proteins Services for IFT20
    Novus Biologicals IFT20 Proteins
    Novus Biologicals IFT20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IFT20
    Cloud-Clone Corp. Proteins for IFT20

    IFT20 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IFT20
    Novus Biologicals IFT20 Antibodies
    Abcam antibodies for IFT20
    Cloud-Clone Corp. Antibodies for IFT20
    ThermoFisher Antibodies for IFT20
    LSBio Antibodies in human, mouse, rat for IFT20

    IFT20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IFT20
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IFT20
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IFT20
    Cloud-Clone Corp. CLIAs for IFT20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IFT: Intraflagellar transport homologs

    1 InterPro protein domain:
     IPR028172 FT20

    Graphical View of Domain Structure for InterPro Entry Q8IY31

    ProtoNet protein and cluster: Q8IY31


    IFT20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFT20_HUMAN, Q8IY31
    Function: Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role
    in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy
    since it is required for trafficking of ATG16L and the expansion of the autophagic compartment

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    IFT20 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ift20):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  no phenotypic analysis  renal/urinary system 

    IFT20 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ift20tm1.2Gjp for IFT20

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFT20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFT20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFT20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFT20

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IFT20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IFT20 (see all 13):
    hsa-miR-579 hsa-miR-3673 hsa-miR-137 hsa-miR-4297 hsa-miR-570 hsa-miR-664 hsa-miR-138-1* hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidIFT20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFT20
    Predesigned siRNA for gene silencing in human, mouse, rat IFT20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFT20

    Clone
    Products:
         
    OriGene clones in human, mouse for IFT20 (see all 6)
    OriGene ORF clones in mouse, rat for IFT20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFT20 (NM_174887)
    Sino Biological Human cDNA Clone for IFT20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFT20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFT20

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IFT20
    Browse ESI BIO Cell Lines and PureStem Progenitors for IFT20 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFT20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IFT20_HUMAN, Q8IY31: Golgi apparatus, cis-Golgi network (By similarity). Cytoplasm, cytoskeleton, microtubule
    organizing center, centrosome, centriole (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By
    similarity). Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of
    the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of
    primary cilia (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus3
    cytoskeleton2
    cytosol2
    extracellular2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0005813centrosome IDA16775004
    GO:0005814centriole IEA--
    GO:0005929cilium IEA--
    GO:0030992intraciliary transport particle B IEA--

    IFT20 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFT20: 
              Primary Cilia in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IFT20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for IFT20 (Q8IY311, 2, 3 ENSP000003505704) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN12Q052092, 3MINT-61777 I2D: score=2 
    TREX1Q9NSU22, 3MINT-67379 I2D: score=2 
    KXD1Q9BQD31, 2, 3, ENSP000002223074EBI-744203,EBI-739657 MINT-66901 I2D: score=5 STRING: ENSP00000222307
    FBF1Q8TES72, 3, ENSP000003242924MINT-66938 I2D: score=1 STRING: ENSP00000324292
    ABI2Q9NYB93, ENSP000002610174I2D: score=4 STRING: ENSP00000261017
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030030cell projection organization ----
    GO:0034067protein localization to Golgi apparatus IMP--
    GO:0042384cilium assembly IMP16775004
    GO:0051642centrosome localization IEA--
    GO:1902017regulation of cilium assembly ISS--

    IFT20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFT20



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IFT20 gene (6 alternative transcripts): 
    NM_001267774.1  NM_001267775.1  NM_001267776.1  NM_001267777.1  NM_001267778.1  NM_174887.3  

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583796 ENST00000579419 ENST00000578009 ENST00000357896(uc002hau.1 uc002haw.1)
    ENST00000395418 ENST00000585089(uc002hav.1) ENST00000585313 ENST00000578122
    ENST00000578985 ENST00000582797 ENST00000322326(uc010wae.1) ENST00000577498
    ENST00000580357 ENST00000578547 ENST00000580991
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IFT20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IFT20 (see all 13):
    hsa-miR-579 hsa-miR-3673 hsa-miR-137 hsa-miR-4297 hsa-miR-570 hsa-miR-664 hsa-miR-138-1* hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidIFT20 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFT20
    Predesigned siRNA for gene silencing in human, mouse, rat IFT20
    Clone
    Products:
         
    OriGene clones in human, mouse for IFT20 (see all 6)
    OriGene ORF clones in mouse, rat for IFT20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFT20 (NM_174887)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFT20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFT20
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFT20
    OriGene qSTAR qPCR primer pairs in human, mouse for IFT20
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFT20
      QuantiTect SYBR Green Assays in human, mouse, rat IFT20
      QuantiFast Probe-based Assays in human, mouse, rat IFT20

    Selected AceView cDNA sequences (see all 226):

    BE782843 BQ007548 CD678728 BU622950 BE245436 BQ219661 BQ018593 BI918835 
    D25835 AI651368 CF126433 BI755072 AA173590 CF593346 CR601295 BX476715 
    BI918218 BX357324 BM313576 BE500998 AF070643 NM_174887 CF594350 CA449964 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IFT20 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8
    SP1:                                -     -                 -     -           -                 -     -         
    SP2:                                -                       -     -           -     -           -     -         
    SP3:                                -     -                 -     -           -     -           -     -         
    SP4:                                -                       -     -           -     -                           
    SP5:                                -                       -     -                                             


    ECgene alternative splicing isoforms for IFT20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IFT20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGGACA
    IFT20 Expression
    About this image


    IFT20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Pancreas (Endocrine System)
    IFT20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFT20 Protein Expression

    UniProtKB/Swiss-Prot: IFT20_HUMAN, Q8IY31
    Tissue specificity: Expressed in almost all tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFT20: 
              Primary Cilia in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFT20
    OriGene qSTAR qPCR primer pairs in human, mouse for IFT20
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFT20
    QuantiTect SYBR Green Assays in human, mouse, rat IFT20
    QuantiFast Probe-based Assays in human, mouse, rat IFT20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFT20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for IFT20 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ift201 , 5 intraflagellar transport 20 homolog (Chlamydomonas)5
    intraflagellar transport 201
    91.16(n)1
    98.48(a)1
      11 (46.74 cM)5
    559781  NM_018854.41  NP_061342.11 
     785363615 
    chicken
    (Gallus gallus)
    Aves IFT201 intraflagellar transport 20 homolog (Chlamydomonas) 75.25(n)
    84.09(a)
      417671  XM_415917.4  XP_415917.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3982442 intraflagellar transport protein 20 80.66(n)    AY048114.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ift201 intraflagellar transport protein 20 74.49(n)
    86.36(a)
      414930  NM_001001833.2  NP_001001833.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG304411 CG30441 49.19(n)
    33.87(a)
      246616  NM_165429.3  NP_724409.3 
    worm
    (Caenorhabditis elegans)
    Secernentea ift-206
    Protein IFT-20 (ift-20) mRNA, complete cds
    36(a)
    1 ↔ 1
    I(5100766-5101674) WBGene00022465


    ENSEMBL Gene Tree for IFT20 (if available)
    TreeFam Gene Tree for IFT20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IFT20 gene

    IFT20 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IFT20
    PGOHUM00000246920


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IFT20 (see all 95)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2000621381,2
    --26656231(+) ATTAGC/GGCTTG 11 A P syn1 mis1 int10--------
    rs1439253421,2
    C,F--26656239(+) TTGAAG/TTTGCT 11 I L N T mis1 int12Minor allele frequency- T:0.00NA EU 5873
    rs344830081,2
    C,F--26656299(+) ACCGAT/CGGCCT 11 /I /V /H /R mis1 int13Minor allele frequency- C:0.00NA EU 5951
    rs1429123581,2
    --26656490(+) TAGACA/GGCAGC 6 -- int10--------
    rs2017518941,2
    C--26656652(+) GTGCTG/TATATG 6 -- int10--------
    rs1510758931,2
    --26656726(+) GTAGGC/TAGTTC 6 -- int10--------
    rs1409864171,2
    C--26656796(+) AAAATA/GCAAAA 6 -- int10--------
    rs1501960051,2
    --26656903(+) CCAACA/GTGGAG 6 -- int10--------
    rs1819235401,2
    --26657072(+) CGAGAA/GAAAAC 6 -- int10--------
    rs1849753161,2
    --26657154(+) CTACTC/TGGGAG 7 Q R int1 mis10--------

    HapMap Linkage Disequilibrium report for IFT20 (26655352 - 26662515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IFT20:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2017CNV Insertion18451855
    nsv519388CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFT20
    DNA2.0 Custom Variant and Variant Library Synthesis for IFT20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614394    OMIM disorders: --

    4 diseases for IFT20:    
    About MalaCards
    retinitis pigmentosa    retinitis    schizophrenia    breast cancer


    IFT20 for disorders           About GeneDecksing


    Export disorders for IFT20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IFT20 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with IFT20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. (PubMed id 16775004)1, 2, 9 Follit J.A.... Pazour G.J. (Mol. Biol. Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Cloning and characterization of the human IFT20 gene. (PubMed id 14672413)1, 2 Yin G.... Mao Y. (Mol. Biol. Rep. 2003)
    4. Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411)1, 2 Wistow G.... Peterson K. (Mol. Vis. 2002)
    5. CCDC41 is required for ciliary vesicle docking to the mother centriole. (PubMed id 23530209)2 Joo K.... Kim J. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    6. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    7. The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. (PubMed id 21490950)1 Fogelgren B....Lipschutz J.H. (PLoS Genet. 2011)
    8. IFT20 is required for opsin trafficking and photoreceptor outer segment development. (PubMed id 21307337)1 Keady B.T....Pazour G.J. (Mol. Biol. Cell 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 90410 HGNC: 30989 AceView: LOC90410 Ensembl:ENSG00000109083 euGenes: HUgn90410
    ECgene: IFT20 H-InvDB: IFT20

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IFT20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IFT20 gene:
    Search GeneIP for patents involving IFT20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IFT20  
     OriGene qPCR primer pairs and template standards for IFT20   OriGene Protein Over-expression Lysate for IFT20  
     OriGene MassSpec something-or-other for IFT20   OriGene clones in human, mouse for IFT20  
     OriGene qSTAR qPCR primer pairs in human, mouse for IFT20   OriGene Purified Protein for IFT20  
     OriGene ORF clones in mouse, rat for IFT20   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IFT20   OriGene Custom Protein Services for IFT20  

     
     
     Block miRNA regulation of human, mouse, rat IFT20 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IFT20
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFT20 Predesigned siRNA for gene silencing in human, mouse, rat IFT20
     QuantiFast Probe-based Assays in human, mouse, rat IFT20 QuantiTect SYBR Green Assays in human, mouse, rat IFT20
     PCR Arrays including human, mouse / rat IFT20 Search Chromatin IP Primers for IFT20
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFT20  Search GeneGlobe Interaction Network for IFT20
     Regulatory tfbs in IFT20 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IFT20 GenScript cDNA clones with any tag delivered in your preferred vector for IFT20
     GenScript Custom Assay Services for IFT20 GenScript Custom overexpressing Cell Line Services for IFT20
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IFT20
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for IFT20
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IFT20 antibodies
     IFT20 proteins
     IFT20 lysates
     Antibodies for IFT20
     See all of Abcam's Antibodies, Kits and Proteins for IFT20
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for IFT20
     Proteins for IFT20
     Antibodies for IFT20
     ELISAs for IFT20
     CLIAs for IFT20



     Browse ESI BIO Cell Lines and PureStem Progenitors for IFT20
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFT20
     SwitchGear 3'UTR luciferase reporter plasmids for IFT20
     SwitchGear Promoter luciferase reporter plasmids for IFT20
     ThermoFisher Antibodies for IFT20
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFT20
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFT20
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFT20
     LSBio Antibodies in human, mouse, rat for IFT20
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IFT20 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4