Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IFRD2 Gene

protein-coding   GIFtS: 50
GCID: GC03M050325

Interferon-Related Developmental Regulator 2

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interferon-Related Developmental Regulator 21 2
Interferon-Related Protein1 2
IFNRP2
SKMc152
SM152
Protein SKMC153

External Ids:    HGNC: 54571   Entrez Gene: 78662   Ensembl: ENSG000002147067   OMIM: 6027255   UniProtKB: Q128943   
ORGUL members:         

Export aliases for IFRD2 gene to outside databases

Previous GC identifers: GC03P049650 GC03P049820 GC03M050180 GC03M050285 GC03M050278 GC03M050302 GC03M050303


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for IFRD2 Gene:
IFRD2 (interferon-related developmental regulator 2) is a protein-coding gene. An important paralog of this gene is IFRD1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the IFRD2 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFRD2 promoter sequence
   Search Chromatin IP Primers for IFRD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFRD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

IFRD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFRD2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M050325:  view genomic region     (about GC identifiers)

Start:
50,325,163 bp from pter      End:
50,330,349 bp from pter
Size:
5,187 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IFRD2_HUMAN, Q12894 (See protein sequence)
Recommended Name: Interferon-related developmental regulator 2  
Size: 506 amino acids; 54814 Da
Caution: It is uncertain whether Met-1 or Met-65 is the initiator
Sequence caution: Sequence=AAH01327.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH01676.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH07265.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH07437.3; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: Q9BVB4

Explore the universe of human proteins at neXtProt for IFRD2: NX_Q12894

Explore proteomics data for IFRD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFRD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006755.4  
    ENSEMBL proteins: 
     ENSP00000402849   ENSP00000408549   ENSP00000392316   ENSP00000415448   ENSP00000413726  
     ENSP00000336936   ENSP00000398971  

    IFRD2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IFRD2
    OriGene Protein Over-expression Lysate for IFRD2
    OriGene MassSpec for IFRD2
    OriGene Custom Protein Services for IFRD2
    GenScript Custom Purified and Recombinant Proteins Services for IFRD2
    Novus Biologicals IFRD2 Protein
    Novus Biologicals IFRD2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IFRD2

     
    Search eBioscience for Proteins for IFRD2 

    IFRD2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IFRD2
    Novus Biologicals IFRD2 Antibodies
    Abcam antibodies for IFRD2
    Cloud-Clone Corp. Antibodies for IFRD2
    Search ThermoFisher Antibodies for IFRD2
    LSBio Antibodies in human, mouse, rat for IFRD2

    IFRD2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IFRD2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IFRD2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IFRD2
    Cloud-Clone Corp. CLIAs for IFRD2
    Search eBioscience for ELISAs for IFRD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR007701 Interferon-rel_develop_reg_N
     IPR006921 Interferon-rel_develop_reg_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q12894

    ProtoNet protein and cluster: Q12894

    1 Blocks protein domain: IPB006921 Interferon-related protein conserved region

    UniProtKB/Swiss-Prot: IFRD2_HUMAN, Q12894
    Similarity: Belongs to the IFRD family


    Find genes that share domains with IFRD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for IFRD2:
    interferon-related developmental regulator 2,transcript from a region commonly deleted in small cell lung cancer
    lines,expressed in the initial stages of embryogenesis,in fetal and adult tissues,(predominantly in skeletal and
    cardiac muscle),rodent immediate early response gene homolog (murine PC4,rat TIS7), IFRD1 family

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005488binding ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with IFRD2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFRD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFRD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFRD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFRD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFRD2:
    hsa-mir-30a-5p (MIRT028528), hsa-mir-26b-5p (MIRT029521), hsa-mir-615-3p (MIRT039999), hsa-mir-124-3p (MIRT002649), hsa-mir-16-5p (MIRT001452)

    Block miRNA regulation of human, mouse, rat IFRD2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate IFRD2:
    hsa-miR-4324 hsa-miR-659 hsa-miR-4251 hsa-miR-3065-3p hsa-miR-3182 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidIFRD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFRD2
    Predesigned siRNA for gene silencing in human, mouse, rat IFRD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFRD2

    Clone
    Products:
         
    OriGene clones in human, mouse for IFRD2 (see all 10)
    OriGene ORF clones in mouse, rat for IFRD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFRD2 (NM_006764)
    Sino Biological Human cDNA Clone for IFRD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFRD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFRD2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IFRD2
    Browse ESI BIO Cell Lines and PureStem Progenitors for IFRD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFRD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with IFRD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Pathway & Disease-focused RT2 Profiler PCR Array including IFRD2: 
              Interferons & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IFRD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFRD2 (Q128941, 3 ENSP000003989714) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OAS3Q9Y6K51, 3, ENSP000002289284EBI-6115935,EBI-6115729 I2D: score=1 STRING: ENSP00000228928
    G3BP1Q132833, ENSP000003485784I2D: score=1 STRING: ENSP00000348578
    USP36Q9P2753, ENSP000003105904I2D: score=1 STRING: ENSP00000310590
    ENSG00000225164ENSP000004094444STRING: ENSP00000409444
    ADPRHENSP000003494964STRING: ENSP00000349496
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFRD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IFRD2 gene: 
    NM_006764.4  

    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417626(uc011bdp.2) ENST00000426499 ENST00000436390(uc003czb.3)
    ENST00000474556 ENST00000464258 ENST00000486322 ENST00000438296 ENST00000492387
    ENST00000469855 ENST00000414734 ENST00000483071 ENST00000489569 ENST00000484043
    ENST00000462001 ENST00000468737 ENST00000336089 ENST00000429673
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IFRD2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate IFRD2:
    hsa-miR-4324 hsa-miR-659 hsa-miR-4251 hsa-miR-3065-3p hsa-miR-3182 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidIFRD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFRD2
    Predesigned siRNA for gene silencing in human, mouse, rat IFRD2
    Clone
    Products:
         
    OriGene clones in human, mouse for IFRD2 (see all 10)
    OriGene ORF clones in mouse, rat for IFRD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFRD2 (NM_006764)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFRD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFRD2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFRD2
    OriGene qSTAR qPCR primer pairs in human, mouse for IFRD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFRD2
      QuantiTect SYBR Green Assays in human, mouse, rat IFRD2
      QuantiFast Probe-based Assays in human, mouse, rat IFRD2

    Selected AceView cDNA sequences (see all 510):

    AI803247 AI290004 AI584127 BM918332 CB305671 CR614993 BE264254 AF040706 
    BU952179 AW410513 BI821378 CR613438 CR604200 BC007437 BE891313 AF040710 
    AW167702 CD673962 BM874367 AW409968 CR594453 BE327260 BG057830 CR621832 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IFRD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTGGGTAG
    IFRD2 Expression
    About this image


    IFRD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 4 entries
             Chorion Laeve
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord
     
     Chorion (Extraembryonic Tissues)
             Chorion Bilayer
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    IFRD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFRD2 Protein Expression

    UniProtKB/Swiss-Prot: IFRD2_HUMAN, Q12894
    Tissue specificity: Expressed in a variety of tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including IFRD2: 
              Interferons & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFRD2
    OriGene qSTAR qPCR primer pairs in human, mouse for IFRD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFRD2
    QuantiTect SYBR Green Assays in human, mouse, rat IFRD2
    QuantiFast Probe-based Assays in human, mouse, rat IFRD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFRD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for IFRD2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifrd21 , 5 interferon-related developmental regulator 21, 5 85.34(n)1
    88.44(a)1
      9 (58.24 cM)5
    159831  NM_025903.21  NP_080179.11 
     1075877185 
    lizard
    (Anolis carolinensis)
    Reptilia IFRD26
    interferon-related developmental regulator 2
    66(a)
    1 ↔ 1
    2(149823577-149848202)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.199392 Transcribed sequence with weak similarity to protein more 72.14(n)    AL856635.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ifrd21 interferon-related developmental regulator 2 59.86(n)
    58.24(a)
      445227  NM_001003621.1  NP_001003621.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316946
    --
    36(a)
    1 → many
    2L(2868627-2874518)
    worm
    (Caenorhabditis elegans)
    Secernentea F58B3.66
    Protein F58B3.6 (F58B3.6) mRNA, complete cds
    27(a)
    1 → many
    IV(11636648-11638209) WBGene00010232


    ENSEMBL Gene Tree for IFRD2 (if available)
    TreeFam Gene Tree for IFRD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IFRD2 gene
    IFRD12  
    1 SIMAP similar gene for IFRD2 using alignment to 5 protein entries:     IFRD2_HUMAN (see all proteins):
    IFRD1

    Find genes that share paralogs with IFRD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IFRD2 (see all 144)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996067561,2
    C--50326091(+) GTCCAC/TGTAGA 2 M V mis10--------
    rs1854921961,2
    C--50326133(+) TTCGCA/GTTCAC 2 R C mis10--------
    rs2002735641,2
    C--50326140(+) TCACCG/ACCCTG 2 /G syn11Minor allele frequency- A:0.00EU 569
    rs2010281581,2
    --50326141(+) CACCGC/TCCTGC 2 D G mis10--------
    rs1909885101,2
    C--50326151(+) CAGGGG/TAGAGG 1 -- int10--------
    rs67926111,2
    C,F,A,H--50326157(+) AGAGGT/GGCCAA 1 -- int111Minor allele frequency- G:0.01NS EA NA 1442
    rs2006220871,2
    C--50326254(+) GGCGCG/AGAAAG 2 /R /C mis11Minor allele frequency- A:0.00EU 569
    rs1390303861,2
    C--50326292(+) TGGCAC/TGGTAC 2 H R mis10--------
    rs1995537951,2
    C--50326304(+) TGTTAC/TTGTCA 2 N S mis10--------
    rs1498651691,2
    C--50326309(+) CTGTCA/GGTGGC 2 T syn10--------

    HapMap Linkage Disequilibrium report for IFRD2 (50325163 - 50330349 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IFRD2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5132n71CNV Loss21882294
    nsv523662CNV Loss19592680
    nsv876770CNV Loss21882294
    dgv5131n71CNV Loss21882294
    nsv876769CNV Loss21882294
    nsv834692CNV Loss17160897
    nsv470561CNV Loss18288195
    nsv834693CNV Loss17160897
    nsv523560CNV Loss19592680
    nsv460531CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFRD2
    DNA2.0 Custom Variant and Variant Library Synthesis for IFRD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602725    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for IFRD2:
    Alopecia areata

    Find genes that share disorders with IFRD2           About GenesLikeMe

    Genetic Association Database (GAD): IFRD2
    Human Genome Epidemiology (HuGE) Navigator: IFRD2 (1 document)

    Export disorders for IFRD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IFRD2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with IFRD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of the rodent immediate early response genes, PC4 and TIS7, resides in the lung cancer tumor suppressor gene region on chromosome 3p21. (PubMed id 9050919)1, 2, 3 Latif F.... Lerman M.I. (Hum. Genet. 1997)
    2. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PubMed id 20689807)1, 4 Wang X....Bell D.A. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7866 HGNC: 5457 AceView: HYAL3 Ensembl:ENSG00000214706 euGenes: HUgn7866
    ECgene: IFRD2 H-InvDB: IFRD2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IFRD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IFRD2 gene:
    Search GeneIP for patents involving IFRD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IFRD2  
     OriGene qPCR primer pairs and template standards for IFRD2   OriGene Protein Over-expression Lysate for IFRD2  
     OriGene MassSpec something-or-other for IFRD2   OriGene clones in human, mouse for IFRD2  
     OriGene qSTAR qPCR primer pairs in human, mouse for IFRD2   OriGene Purified Protein for IFRD2  
     OriGene ORF clones in mouse, rat for IFRD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IFRD2   OriGene Custom Protein Services for IFRD2  

     
     
     Block miRNA regulation of human, mouse, rat IFRD2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IFRD2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFRD2 Predesigned siRNA for gene silencing in human, mouse, rat IFRD2
     QuantiFast Probe-based Assays in human, mouse, rat IFRD2 QuantiTect SYBR Green Assays in human, mouse, rat IFRD2
     PCR Arrays including human, mouse, rat IFRD2 Search Chromatin IP Primers for IFRD2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFRD2  Search GeneGlobe Interaction Network for IFRD2
     Regulatory tfbs in IFRD2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IFRD2 GenScript cDNA clones with any tag delivered in your preferred vector for IFRD2
     GenScript Custom Assay Services for IFRD2 GenScript Custom overexpressing Cell Line Services for IFRD2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IFRD2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for IFRD2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IFRD2 antibodies
     IFRD2 proteins
     IFRD2 lysates
     Antibodies for IFRD2
     See all of Abcam's Antibodies, Kits and Proteins for IFRD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for IFRD2
     Antibodies for IFRD2
     ELISAs for IFRD2
     CLIAs for IFRD2



     Browse ESI BIO Cell Lines and PureStem Progenitors for IFRD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFRD2
     SwitchGear 3'UTR luciferase reporter plasmids for IFRD2
     SwitchGear Promoter luciferase reporter plasmids for IFRD2
     Search ThermoFisher Antibodies for IFRD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFRD2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFRD2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFRD2
     LSBio Antibodies in human, mouse, rat for IFRD2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for IFRD2
      Search eBioscience for proteins for IFRD2
      Search eBioscience for elisas for IFRD2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IFRD2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4