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Aliases for IFRD2 Gene

Aliases for IFRD2 Gene

  • Interferon Related Developmental Regulator 2 2 3 5
  • Interferon-Related Protein 2 3
  • Interferon-Related Developmental Regulator 2 3
  • Protein SKMC15 4
  • SKMc15 3
  • IFNRP 3
  • SM15 3

External Ids for IFRD2 Gene

Previous GeneCards Identifiers for IFRD2 Gene

  • GC03P049650
  • GC03P049820
  • GC03M050180
  • GC03M050285
  • GC03M050278
  • GC03M050302
  • GC03M050303
  • GC03M050325

Summaries for IFRD2 Gene

GeneCards Summary for IFRD2 Gene

IFRD2 (Interferon Related Developmental Regulator 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is IFRD1.

Additional gene information for IFRD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFRD2 Gene

Genomics for IFRD2 Gene

GeneHancer (GH) Regulatory Elements for IFRD2 Gene

Promoters and enhancers for IFRD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I050290 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.8 833 3.5 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF213 ZNF207 IFRD2 HYAL3 CYB561D2 HYAL1 PIR42147
GH03I050234 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.3 +47.7 47662 21.2 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 GNAI2 HYAL3 RBM5 SEMA3F-AS1 RBM6 HYAL1 CYB561D2 RHOA-IT1 AMT HEMK1
GH03I050227 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 +63.9 63918 4.8 HDGF ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 ZNF143 SP3 SP5 GNAI2 MIR5787 HYAL3 RBM6 SEMA3F-AS1 RBM5 SEMA3B SEMA3B-AS1 LSMEM2 TMEM115
GH03I050332 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 -44.8 -44754 9.4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 RASSF1 RASSF1-AS1 HYAL3 CYB561D2 RBM6 SEMA3F-AS1 NICN1 RBM5 RHOA-IT1 TMEM115
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFRD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFRD2 gene promoter:

Genomic Locations for IFRD2 Gene

Genomic Locations for IFRD2 Gene
5,187 bases
Minus strand

Genomic View for IFRD2 Gene

Genes around IFRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFRD2 Gene

Proteins for IFRD2 Gene

  • Protein details for IFRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon-related developmental regulator 2
    Protein Accession:
    Secondary Accessions:
    • Q9BVB4
    • Q9UJ88

    Protein attributes for IFRD2 Gene

    506 amino acids
    Molecular mass:
    54814 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01327.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH01676.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH07265.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH07437.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IFRD2 Gene


neXtProt entry for IFRD2 Gene

Post-translational modifications for IFRD2 Gene

No Post-translational modifications

Other Protein References for IFRD2 Gene

No data available for DME Specific Peptides for IFRD2 Gene

Domains & Families for IFRD2 Gene

Gene Families for IFRD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for IFRD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IFRD family.
  • Belongs to the IFRD family.
genes like me logo Genes that share domains with IFRD2: view

Function for IFRD2 Gene

Molecular function for IFRD2 Gene

GENATLAS Biochemistry:
interferon-related developmental regulator 2,transcript from a region commonly deleted in small cell lung cancer lines,expressed in the initial stages of embryogenesis,in fetal and adult tissues,(predominantly in skeletal and cardiac muscle),rodent immediate early response gene homolog (murine PC4,rat TIS7), IFRD1 family

Phenotypes From GWAS Catalog for IFRD2 Gene

Gene Ontology (GO) - Molecular Function for IFRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with IFRD2: view
genes like me logo Genes that share phenotypes with IFRD2: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFRD2 Gene

Localization for IFRD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFRD2 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IFRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA,IDA 21630459
genes like me logo Genes that share ontologies with IFRD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IFRD2 Gene

Pathways & Interactions for IFRD2 Gene

SuperPathways for IFRD2 Gene

No Data Available

Interacting Proteins for IFRD2 Gene

Gene Ontology (GO) - Biological Process for IFRD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for IFRD2 Gene

Drugs & Compounds for IFRD2 Gene

No Compound Related Data Available

Transcripts for IFRD2 Gene

Unigene Clusters for IFRD2 Gene

Interferon-related developmental regulator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFRD2 Gene

No ASD Table

Relevant External Links for IFRD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFRD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFRD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFRD2 Gene

This gene is overexpressed in Lung (57.4) and Pancreas (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFRD2 Gene

Protein tissue co-expression partners for IFRD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IFRD2 Gene:


SOURCE GeneReport for Unigene cluster for IFRD2 Gene:


mRNA Expression by UniProt/SwissProt for IFRD2 Gene:

Tissue specificity: Expressed in a variety of tissues.

Evidence on tissue expression from TISSUES for IFRD2 Gene

  • Nervous system(4.8)
  • Muscle(4.3)
  • Kidney(4.2)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with IFRD2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFRD2 Gene

Orthologs for IFRD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFRD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFRD2 33 34
  • 99.21 (n)
(Canis familiaris)
Mammalia IFRD2 33
  • 88.71 (n)
(Rattus norvegicus)
Mammalia Ifrd2 33
  • 85.87 (n)
(Mus musculus)
Mammalia Ifrd2 33 16 34
  • 85.34 (n)
(Bos Taurus)
Mammalia IFRD2 33 34
  • 85.3 (n)
(Monodelphis domestica)
Mammalia IFRD2 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia IFRD2 34
  • 62 (a)
(Anolis carolinensis)
Reptilia IFRD2 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ifrd2 33
  • 61.67 (n)
Str.19939 33
(Danio rerio)
Actinopterygii ifrd2 33 34
  • 59.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31694 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F58B3.6 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6747 34
  • 43 (a)
Species where no ortholog for IFRD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFRD2 Gene

Gene Tree for IFRD2 (if available)
Gene Tree for IFRD2 (if available)

Paralogs for IFRD2 Gene

Paralogs for IFRD2 Gene

(1) SIMAP similar genes for IFRD2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IFRD2: view

Variants for IFRD2 Gene

Sequence variations from dbSNP and Humsavar for IFRD2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1002294456 -- 50,294,356(-) C/G upstream_transcript_variant
rs1002747349 -- 50,288,424(-) A/T coding_sequence_variant, synonymous_variant
rs1003106244 -- 50,290,829(-) T/C intron_variant
rs1003484589 -- 50,290,567(-) G/A coding_sequence_variant, synonymous_variant
rs1004079262 -- 50,292,120(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IFRD2 Gene

Variant ID Type Subtype PubMed ID
dgv8316n54 CNV loss 21841781
dgv8317n54 CNV loss 21841781
esv2759148 CNV loss 17122850
nsv460531 CNV loss 19166990
nsv470561 CNV loss 18288195
nsv523560 CNV loss 19592680
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv834692 CNV loss 17160897
nsv834693 CNV loss 17160897
nsv954855 CNV deletion 24416366

Variation tolerance for IFRD2 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFRD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFRD2 Gene

Disorders for IFRD2 Gene

Additional Disease Information for IFRD2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IFRD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFRD2 Gene

Publications for IFRD2 Gene

  1. The human homolog of the rodent immediate early response genes, PC4 and TIS7, resides in the lung cancer tumor suppressor gene region on chromosome 3p21. (PMID: 9050919) Latif F … Lerman MI (Human genetics 1997) 2 3 4 58
  2. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X … Bell DA (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for IFRD2 Gene

Sources for IFRD2 Gene

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