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Aliases for IFRD2 Gene

Aliases for IFRD2 Gene

  • Interferon Related Developmental Regulator 2 2 3 5
  • Interferon-Related Protein 2 3
  • Interferon-Related Developmental Regulator 2 3
  • Protein SKMC15 4
  • SKMc15 3
  • IFNRP 3
  • SM15 3

External Ids for IFRD2 Gene

Previous GeneCards Identifiers for IFRD2 Gene

  • GC03P049650
  • GC03P049820
  • GC03M050180
  • GC03M050285
  • GC03M050278
  • GC03M050302
  • GC03M050303
  • GC03M050325

Summaries for IFRD2 Gene

GeneCards Summary for IFRD2 Gene

IFRD2 (Interferon Related Developmental Regulator 2) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is IFRD1.

Additional gene information for IFRD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFRD2 Gene

Genomics for IFRD2 Gene

Regulatory Elements for IFRD2 Gene

Enhancers for IFRD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H050257 2 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +25.4 25417 19 HDGF PKNOX1 ARNT ARID4B DMAP1 ZNF2 ZBTB7B CBX5 ZNF207 ZNF143 HYAL3 CYB561D2 IFRD2 GNAI2 AMT HYAL1 AMIGO3 DOCK3 SEMA3B SEMA3B-AS1
GH03H050234 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +47.7 47663 21 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 HYAL3 GNAI2 HYAL1 CYB561D2 SEMA3B-AS1 SEMA3B LSMEM2 NAT6 IFRD2 SEMA3F-AS1
GH03H050227 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +63.8 63796 4 HDGF ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 SP5 ZHX2 HYAL3 RBM6 SEMA3F-AS1 RBM5 SEMA3B SEMA3B-AS1 LSMEM2 TMEM115 IFRD2 RASSF1
GH03H050332 1.6 FANTOM5 ENCODE dbSUPER 11 -44.8 -44754 9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 HYAL3 CYB561D2 NICN1 IFRD2 LSMEM2 HYAL1 RBM6 SEMA3F ENSG00000230454 RASSF1
GH03H050192 1.3 Ensembl ENCODE 11.2 +98.5 98497 4 PKNOX1 FOXA2 ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS SP5 HYAL3 RBM6 GNAI2 SEMA3F SEMA3F-AS1 SEMA3B-AS1 SEMA3B LSMEM2 HYAL1 IFRD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFRD2 on UCSC Golden Path with GeneCards custom track

Promoters for IFRD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152337 818 1401 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 SP3

Transcription factor binding sites by QIAGEN in the IFRD2 gene promoter:

Genomic Location for IFRD2 Gene

Chromosome:
3
Start:
50,287,732 bp from pter
End:
50,292,918 bp from pter
Size:
5,187 bases
Orientation:
Minus strand

Genomic View for IFRD2 Gene

Genes around IFRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFRD2 Gene

Proteins for IFRD2 Gene

  • Protein details for IFRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12894-IFRD2_HUMAN
    Recommended name:
    Interferon-related developmental regulator 2
    Protein Accession:
    Q12894
    Secondary Accessions:
    • Q9BVB4
    • Q9UJ88

    Protein attributes for IFRD2 Gene

    Size:
    506 amino acids
    Molecular mass:
    54814 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01327.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH01676.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH07265.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH07437.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IFRD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFRD2 Gene

Post-translational modifications for IFRD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFRD2 Gene

No data available for DME Specific Peptides for IFRD2 Gene

Domains & Families for IFRD2 Gene

Gene Families for IFRD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for IFRD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q12894

UniProtKB/Swiss-Prot:

IFRD2_HUMAN :
  • Belongs to the IFRD family.
Family:
  • Belongs to the IFRD family.
genes like me logo Genes that share domains with IFRD2: view

Function for IFRD2 Gene

Molecular function for IFRD2 Gene

GENATLAS Biochemistry:
interferon-related developmental regulator 2,transcript from a region commonly deleted in small cell lung cancer lines,expressed in the initial stages of embryogenesis,in fetal and adult tissues,(predominantly in skeletal and cardiac muscle),rodent immediate early response gene homolog (murine PC4,rat TIS7), IFRD1 family

Phenotypes From GWAS Catalog for IFRD2 Gene

Gene Ontology (GO) - Molecular Function for IFRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with IFRD2: view
genes like me logo Genes that share phenotypes with IFRD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IFRD2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IFRD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFRD2 Gene

Localization for IFRD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFRD2 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IFRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with IFRD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IFRD2 Gene

Pathways & Interactions for IFRD2 Gene

SuperPathways for IFRD2 Gene

No Data Available

Interacting Proteins for IFRD2 Gene

Gene Ontology (GO) - Biological Process for IFRD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IFRD2 Gene

Drugs & Compounds for IFRD2 Gene

No Compound Related Data Available

Transcripts for IFRD2 Gene

Unigene Clusters for IFRD2 Gene

Interferon-related developmental regulator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IFRD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IFRD2 Gene

No ASD Table

Relevant External Links for IFRD2 Gene

GeneLoc Exon Structure for
IFRD2
ECgene alternative splicing isoforms for
IFRD2

Expression for IFRD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFRD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFRD2 Gene

This gene is overexpressed in Lung (57.4) and Pancreas (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFRD2 Gene



Protein tissue co-expression partners for IFRD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IFRD2 Gene:

IFRD2

SOURCE GeneReport for Unigene cluster for IFRD2 Gene:

Hs.743323

mRNA Expression by UniProt/SwissProt for IFRD2 Gene:

Q12894-IFRD2_HUMAN
Tissue specificity: Expressed in a variety of tissues.

Evidence on tissue expression from TISSUES for IFRD2 Gene

  • Nervous system(4.8)
  • Muscle(4.3)
  • Kidney(4.2)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with IFRD2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFRD2 Gene

Orthologs for IFRD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFRD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFRD2 33 34
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia IFRD2 33
  • 88.71 (n)
rat
(Rattus norvegicus)
Mammalia Ifrd2 33
  • 85.87 (n)
mouse
(Mus musculus)
Mammalia Ifrd2 33 16 34
  • 85.34 (n)
cow
(Bos Taurus)
Mammalia IFRD2 33 34
  • 85.3 (n)
oppossum
(Monodelphis domestica)
Mammalia IFRD2 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFRD2 34
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFRD2 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ifrd2 33
  • 61.67 (n)
Str.19939 33
zebrafish
(Danio rerio)
Actinopterygii ifrd2 33 34
  • 59.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31694 34
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F58B3.6 34
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6747 34
  • 43 (a)
OneToMany
Species where no ortholog for IFRD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFRD2 Gene

ENSEMBL:
Gene Tree for IFRD2 (if available)
TreeFam:
Gene Tree for IFRD2 (if available)

Paralogs for IFRD2 Gene

Paralogs for IFRD2 Gene

(1) SIMAP similar genes for IFRD2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IFRD2: view

Variants for IFRD2 Gene

Sequence variations from dbSNP and Humsavar for IFRD2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1002294456 -- 50,294,356(+) TCGAA(C/G)TCTTG intron-variant, upstream-variant-2KB
rs1002747349 -- 50,288,424(+) CGTGG(A/T)ACCTT downstream-variant-500B, reference, synonymous-codon
rs1003106244 -- 50,290,829(+) GCTGG(C/T)GCACT intron-variant
rs1003484589 -- 50,290,567(+) AGGCT(A/G)TCCTC reference, synonymous-codon
rs1004079262 -- 50,292,120(+) GAGGG(G/T)GTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFRD2 Gene

Variant ID Type Subtype PubMed ID
dgv8316n54 CNV loss 21841781
dgv8317n54 CNV loss 21841781
esv2759148 CNV loss 17122850
nsv460531 CNV loss 19166990
nsv470561 CNV loss 18288195
nsv523560 CNV loss 19592680
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv834692 CNV loss 17160897
nsv834693 CNV loss 17160897
nsv954855 CNV deletion 24416366

Variation tolerance for IFRD2 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFRD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFRD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFRD2 Gene

Disorders for IFRD2 Gene

Relevant External Links for IFRD2

Genetic Association Database (GAD)
IFRD2
Human Genome Epidemiology (HuGE) Navigator
IFRD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFRD2

No disorders were found for IFRD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFRD2 Gene

Publications for IFRD2 Gene

  1. The human homolog of the rodent immediate early response genes, PC4 and TIS7, resides in the lung cancer tumor suppressor gene region on chromosome 3p21. (PMID: 9050919) Latif F … Lerman MI (Human genetics 1997) 2 3 4 60
  2. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X … Bell DA (PloS one 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for IFRD2 Gene

Sources for IFRD2 Gene

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