Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFRD1 Gene

protein-coding   GIFtS: 56
GCID: GC07P112063

interferon-related developmental regulator 1

 Explore 11 diseases affiliated with
IFRD1 via our new
 Human Malady Compendium 
Biological research products
for IFRD1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interferon-Related Developmental Regulator 11 2     12-O-Tetradecanoylphorbol-13-Acetate-Induced Sequence 72
PC41 2     Pheochromocytoma Cell-42
TIS71 2     TPA Induced Sequence 72
Nerve Growth Factor-Inducible Protein PC42 3     

External Ids:    HGNC: 54561   Entrez Gene: 34752   Ensembl: ENSG000000066527   OMIM: 6035025   UniProtKB: O004583   

Export aliases for IFRD1 gene to outside databases

Previous GC identifers: GC07P110574 GC07P111609 GC07P111651 GC07P111684 GC07P111850 GC07P106430


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFRD1:
This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a
transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during
embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy
with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate
splicing results in multiple transcript variants. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: IFRD1_HUMAN, O00458
Function: Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by
NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity)

Gene Wiki entry for IFRD1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFRD1 gene promoter:
         Sp1   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): IFRD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFRD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.1   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31.1

IFRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFRD1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P112063:  view genomic region     (about GC identifiers)

Start:
112,063,023 bp from pter      End:
112,121,072 bp from pter
Size:
58,050 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 111,431,453-111,484,752     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IFRD1_HUMAN, O00458 (See protein sequence)
Recommended Name: Interferon-related developmental regulator 1  
Size: 451 amino acids; 50269 Da
Subunit: Interacts with PSIP1/LEDGF
Secondary accessions: B7Z5G1 O75234 Q5U013 Q9BVE4
Alternative splicing: 2 isoforms:  O00458-1   O00458-2   

Explore the universe of human proteins at neXtProt for IFRD1: NX_O00458

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00458

  • IFRD1 Protein expression data from MOPED and PaxDb:    About this image 
    IFRD1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001007246.1  NP_001184008.1  NP_001184009.1  NP_001541.2  

    ENSEMBL proteins: 
     ENSP00000391379   ENSP00000005558   ENSP00000397592   ENSP00000402453   ENSP00000413893  
     ENSP00000384477   ENSP00000397314   ENSP00000437250   ENSP00000402177   ENSP00000403203  
     ENSP00000435635   ENSP00000439188  

    Human Recombinant Protein Products for IFRD1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IFRD1
    OriGene Protein Over-expression Lysate (see all 3): IFRD1
    OriGene Custom Protein Services for IFRD1 
    GenScript Custom Purified and Recombinant Proteins Services for IFRD1
    Novus Biologicals IFRD1 Protein
    Novus Biologicals IFRD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IFRD1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    IFRD1 for ontologies           About GeneDecksing



    IFRD1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IFRD1 
    GenScript Custom Superior Antibodies Services for IFRD1
    Novus Biologicals IFRD1 Antibodies
    Abcam antibodies for IFRD1 
    Uscn Antibodies for IFRD1
    ThermoFisher Antibodies for IFRD1

    Assay Products for IFRD1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IFRD1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IFRD1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IFRD1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011989 ARM-like
     IPR007701 Interferon-rel_develop_reg_N
     IPR006921 Interferon-rel_develop_reg_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O00458

    ProtoNet protein and cluster: O00458

    1 Blocks protein family: IPB006921 Interferon-related protein conserved region

    UniProtKB/Swiss-Prot: IFRD1_HUMAN, O00458
    Similarity: Belongs to the IFRD family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFRD1_HUMAN, O00458
    Function: Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by
    NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity)

         Genatlas biochemistry entry for IFRD1:
    interferon-related developmental regulator 1,rat PC4 homolog,expressed in differentiating tissues such as nervous
    tissue,kidney,lung,embryonic and adult skeletal muscle

    Phenotypes:
         1 GenomeRNAi human phenotype for IFRD1:
     Increased cell number in G1, a 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ifrd1):
     growth/size  muscle 

    IFRD1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Ifrd1tm1Lah for IFRD1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IFRD1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFRD1:
    hsa-mir-30a (MIRT005143), hsa-let-7b (MIRT001623), hsa-mir-16 (MIRT001454)

    OriGene 3'-UTR Clone (see all 2): IFRD1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFRD1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate IFRD1 (see all 20):
    hsa-miR-3128 hsa-miR-323-3p hsa-miR-607 hsa-miR-16-1* hsa-miR-216b hsa-miR-890 hsa-miR-548a-3p hsa-miR-548g
    SwitchGear 3'UTR luciferase reporter plasmidIFRD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFRD1 (see all 7)
    OriGene shRNA RFP: IFRD1
    OriGene siRNA: IFRD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFRD1
    Sirion Biotech Custom design and validation of potent shRNA sequences against IFRD1 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFRD1
    Sirion Biotech Customized adenovirus for overexpression of IFRD1 
    Sirion Biotech Customized adenovirus for potent knockdown of IFRD1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFRD1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFRD1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): IFRD1 (NM_001550)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFRD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFRD1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IFRD1
    Search LifeMap BioReagents cell lines for IFRD1
    Sirion Biotech Customized stable knockdown cell line services for IFRD1 
    Sirion Biotech Customized inducible knockdown cell line services for IFRD1
    Sirion Biotech Customized stable overexpressing cell line services for IFRD1
    Sirion Biotech Customized inducible overexpressing cell line services for IFRD1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFRD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFRD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/28 Interacting proteins for IFRD1 (O004582, 3 ENSP000000055584) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565243, ENSP000002646064I2D: score=2 STRING: ENSP00000264606
    MYOD1P151723, ENSP000002500034I2D: score=1 STRING: ENSP00000250003
    SAP30O754463, ENSP000002965044I2D: score=1 STRING: ENSP00000296504
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    MEF2CQ064133, ENSP000003962194I2D: score=2 STRING: ENSP00000396219
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007518myoblast cell fate determination TAS7756174
    GO:0007527adult somatic muscle development IEA--
    GO:0042692muscle cell differentiation ----

    IFRD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFRD1
    Search CenterWatch for drugs/clinical trials and news about IFRD1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFRD1 gene (4 alternative transcripts): 
    NM_001007245.2  NM_001197079.1  NM_001197080.1  NM_001550.3  

    Unigene Cluster for IFRD1:

    Interferon-related developmental regulator 1
    Hs.7879  [show with all ESTs]
    Unigene Representative Sequence: NM_001007245
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432734 ENST00000005558 ENST00000443101 ENST00000445335 ENST00000417662
    ENST00000403825(uc003vgh.3 uc011kmn.2 uc003vgj.3 uc011kmo.2 uc011kmp.2)
    ENST00000429071(uc003vgi.3) ENST00000476927 ENST00000440625 ENST00000466459
    ENST00000486688 ENST00000421296 ENST00000489994(uc003vgk.3) ENST00000470441
    ENST00000462155 ENST00000535603

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): IFRD1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFRD1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate IFRD1 (see all 20):
    hsa-miR-3128 hsa-miR-323-3p hsa-miR-607 hsa-miR-16-1* hsa-miR-216b hsa-miR-890 hsa-miR-548a-3p hsa-miR-548g
    SwitchGear 3'UTR luciferase reporter plasmidIFRD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFRD1 (see all 7)
    OriGene shRNA RFP: IFRD1
    OriGene siRNA: IFRD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFRD1
    Sirion Biotech Custom design and validation of potent shRNA sequences against IFRD1 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFRD1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFRD1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): IFRD1 (NM_001550)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFRD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFRD1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFRD1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFRD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFRD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFRD1

    Additional cDNA sequence: 

    AK298894.1 AK308066.1 AK313211.1 AK315967.1 BC001272.1 BT019889.1 BT019890.1 BX648799.1 

    18 DOTS entries:

    DT.92439384  DT.317950  DT.99996008  DT.91839142  DT.100736122  DT.302968  DT.40268349  DT.92000883 
    DT.100028556  DT.100656628  DT.95371579  DT.121115877  DT.100724749  DT.100786607  DT.102823386  DT.121115952 
    DT.101957293  DT.121115933 

    24/296 AceView cDNA sequences (see all 296):

    BM468649 D20227 BM828279 BQ889568 AU143090 AW009341 CN482885 AU118046 
    AA133453 BX092897 AI820689 BM453688 AA725398 AL532457 BG181092 BM799738 
    BM825719 T32650 AL553296 AI368750 BI260979 BM729289 CR602983 AL135535 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFRD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGAATTAGC
    IFRD1 Expression
    About this image
    See IFRD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFRD1

    SOURCE GeneReport for Unigene cluster: Hs.7879

    UniProtKB/Swiss-Prot: IFRD1_HUMAN, O00458
    Tissue specificity: Expressed in a variety of tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including IFRD1: 
              TGFB/BMP Signaling Pathway in human mouse rat
              Interferons & Receptors in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFRD1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFRD1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFRD1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFRD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFRD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IFRD1 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves IFRD11 interferon-related developmental regulator 1 77.88(n)
    83.64(a)
      395226  NM_001001468.1  NP_001001468.1 
    lizard
    (Anolis carolinensis)
    Reptilia IFRD16
    --
    82(a)
    1 ↔ 1
    5(58489980-58503099)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691232 hypothetical protein MGC69123 74.12(n)    BC057749.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj67a062 Transcribed sequence with weak similarity to protein more 72.12(n)    CK239527.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316941 CG31694 44.75(n)
    38(a)
      33489  NM_164511.1  NP_722858.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F58B3.61 Protein F58B3.6 43.16(n)
    29.49(a)
      178090  NM_069796.3  NP_502197.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATSAT326
    Interferon-related developmental regulator domain-...
    23(a)
    1 → many
    1(9668584-9671616)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 6)
    interferon-related developmental regulator, putati...
    interferon-related developmental regulator, putati...
    (see all 6)
    21(a)
    20(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    7(23924899-23930229)
    3(19196361-19202850)


    ENSEMBL Gene Tree for IFRD1 (if available)
    TreeFam Gene Tree for IFRD1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFRD1 gene
    IFRD22  
    1 SIMAP similar gene for IFRD1 using alignment to 14 protein entries:     IFRD1_HUMAN (see all proteins):
    IFRD2

    IFRD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1032 NCBI SNPs in IFRD1 are shown (see all 1032    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs133098811,2
    H--106467591(+) ggctgG/Agaata 4 -- int14Minor allele frequency- A:0.00NS EA 420
    rs27086101,2
    C,F,A,H--106469325(-) ATCCAT/CAAAAT 4 -- int126Minor allele frequency- C:0.49NS EA NA WA CSA 2768
    rs357304631,2
    C--106470563(+) TCATT-/AAGACT 4 -- int13Minor allele frequency- A:0.17NA CSA 6
    rs117694411,2
    C,H--111429620(+) CTACTA/GTTCCT 2 -- us2k14Minor allele frequency- G:0.00NS EA 416
    rs119733271,2
    C,H--111429698(+) GGTGAG/AATTAT 2 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs734284271,2
    C--111430147(+) GTGAAC/TCAGAG 2 -- us2k12Minor allele frequency- T:0.04WA 120
    rs171596131,2
    C,F,H--111430882(+) CAGGCA/TAGATT 2 -- us2k111Minor allele frequency- T:0.10NA NS EA WA CSA 800
    rs800267711,2
    --111430909(+) AGTTGC/TGCTCC 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs171596151,2
    C,F,H--111431048(+) TTCCCA/GCAAGA 2 -- us2k111Minor allele frequency- G:0.10NA NS EA WA CSA 804
    rs796229051,2
    --111431223(+) AGAATA/GAATAG 2 -- us2k11Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for IFRD1 (112063023 - 112121072 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IFRD1
         1 CNV: 5246
    Human Gene Mutation Database (HGMD): IFRD1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFRD1
    DNA2.0 Custom Variant and Variant Library Synthesis for IFRD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IFRD1 for disorders           About GeneDecksing

    OMIM gene information: 603502    OMIM disorders: --

    11 diseases for IFRD1:    About MalaCards
    cystic fibrosis lung disease    cystic fibrosis    pheochromocytoma    fibrosis
    neuropathy    ataxia    myelodysplastic syndrome    thrombocytopenia
    purpura    choroiditis    lung cancer

    Human Genome Epidemiology (HuGE) Navigator: IFRD1 (2 documents)

    Export disorders for IFRD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFRD1 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with IFRD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes. (PubMed id 9722946)1, 2, 3, 9 Buanne P....Tirone F. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. (PubMed id 9822615)1, 2 Ge H.... Roeder R.G. (1998)
    5. PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C. (PubMed id 15743821)1, 9 Micheli L....Tirone F. (2005)
    6. Nerve growth factor regulates the subcellular localization of the nerve growth factor-inducible protein PC4 in PC12 cells. (PubMed id 8028043)1, 9 Guardavaccaro D....Tirone F. (1994)
    7. Inhibition of differentiation in myoblasts deprived of the interferon-related protein PC4. (PubMed id 7756174)1, 9 Guardavaccaro D....Tirone F. (1995)
    8. IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23. (PubMed id 19409521)1, 9 Brkanac Z....Raskind W.H. (2009)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    10. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3475 HGNC: 5456 AceView: IFRD1 Ensembl:ENSG00000006652 euGenes: HUgn3475
    ECgene: IFRD1 H-InvDB: IFRD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFRD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFRD1 gene:
    Search GeneIP for patents involving IFRD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for IFRD1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFRD1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFRD1  
     OriGene Protein Over-expression Lysate for IFRD1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for IFRD1   OriGene 3'-UTR Clone for IFRD1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFRD1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFRD1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for IFRD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IFRD1   OriGene Custom Protein Services for IFRD1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFRD1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFRD1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFRD1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFRD1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFRD1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFRD1
     GenScript Custom Purified and Recombinant Proteins Services for IFRD1 GenScript cDNA clones with any tag delivered in your preferred vector for IFRD1
     GenScript Custom Assay Services for IFRD1 GenScript Custom Superior Antibodies Services for IFRD1
     GenScript Custom overexpressing Cell Line Services for IFRD1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IFRD1 promoter
     Search Chromatin IP Primers for IFRD1
     RT2 qPCR Primer Assay in human, mouse, rat IFRD1
     GNC Network for IFRD1
     SABiosciences PCR Arrays including human, mouse, rat IFRD1
     Search Tocris compounds for IFRD1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IFRD1 antibodies
     IFRD1 proteins
     IFRD1 lysates
     Antibodies for IFRD1
     See all of Abcam's Antibodies, Kits and Proteins for IFRD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     IFRD1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for IFRD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFRD1
     SwitchGear 3'UTR luciferase reporter plasmids for IFRD1
     SwitchGear Promoter luciferase reporter plasmids for IFRD1
     ThermoFisher Antibodies for IFRD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFRD1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IFRD1
    Sirion Biotech Customized:
     stable knockdown cell line services for IFRD1
     inducible knockdown cell line services for IFRD1
     design and validation of potent shRNA sequences against IFRD1
     adenovirus for potent knockdown of IFRD1
     adenovirus for overexpression of IFRD1
     stable overexpressing cell line services for IFRD1
     inducible overexpressing cell line services for IFRD1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IFRD1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4