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Aliases for IFNW1 Gene

Aliases for IFNW1 Gene

  • Interferon, Omega 1 2 3 5
  • Interferon Alpha-II-1 4
  • Interferon Omega-1 2
  • IFN-Omega 1 2

External Ids for IFNW1 Gene

Previous GeneCards Identifiers for IFNW1 Gene

  • GC09M021468
  • GC09M021341
  • GC09M021130

Summaries for IFNW1 Gene

Entrez Gene Summary for IFNW1 Gene

  • The protein encoded by this gene is an interferon and possesses antiviral activity. The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. This intronless gene has several pseudogenes spread throughout the genome. [provided by RefSeq, Nov 2015]

GeneCards Summary for IFNW1 Gene

IFNW1 (Interferon, Omega 1) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Jak-STAT signaling pathway. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

Gene Wiki entry for IFNW1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNW1 Gene

Genomics for IFNW1 Gene

Regulatory Elements for IFNW1 Gene

Enhancers for IFNW1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFNW1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNW1 Gene

21,140,214 bp from pter
21,142,145 bp from pter
1,932 bases
Minus strand

Genomic View for IFNW1 Gene

Genes around IFNW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNW1 Gene

Proteins for IFNW1 Gene

  • Protein details for IFNW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon omega-1
    Protein Accession:
    Secondary Accessions:
    • Q13168
    • Q5U802
    • Q5VWD0
    • Q7M4P5

    Protein attributes for IFNW1 Gene

    195 amino acids
    Molecular mass:
    22319 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IFNW1 Gene

neXtProt entry for IFNW1 Gene

Proteomics data for IFNW1 Gene at MOPED

Post-translational modifications for IFNW1 Gene

Other Protein References for IFNW1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNW1 Gene

Domains & Families for IFNW1 Gene

Gene Families for IFNW1 Gene

Suggested Antigen Peptide Sequences for IFNW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNW1: view

Function for IFNW1 Gene

Molecular function for IFNW1 Gene

GENATLAS Biochemistry:
interferon type I,omega 1,leukocyte
genes like me logo Genes that share phenotypes with IFNW1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNW1 Gene

Localization for IFNW1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNW1 Gene


Subcellular locations from

Jensen Localization Image for IFNW1 Gene COMPARTMENTS Subcellular localization image for IFNW1 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for IFNW1 Gene

Pathways & Interactions for IFNW1 Gene

genes like me logo Genes that share pathways with IFNW1: view

SIGNOR curated interactions for IFNW1 Gene


Gene Ontology (GO) - Biological Process for IFNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0030183 B cell differentiation IBA --
genes like me logo Genes that share ontologies with IFNW1: view

Drugs & Compounds for IFNW1 Gene

No Compound Related Data Available

Transcripts for IFNW1 Gene

mRNA/cDNA for IFNW1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNW1 Gene

Interferon, omega 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNW1 Gene

No ASD Table

Relevant External Links for IFNW1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNW1 Gene

mRNA expression in normal human tissues for IFNW1 Gene

mRNA differential expression in normal tissues according to GTEx for IFNW1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.3) and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for IFNW1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFNW1 Gene

SOURCE GeneReport for Unigene cluster for IFNW1 Gene Hs.73010

genes like me logo Genes that share expression patterns with IFNW1: view

Protein tissue co-expression partners for IFNW1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IFNW1 Gene

Orthologs for IFNW1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNW1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100336885 35
  • 79.21 (n)
  • 67.53 (a)
-- 36
  • 65 (a)
-- 36
  • 64 (a)
-- 36
  • 63 (a)
-- 36
  • 64 (a)
-- 36
  • 66 (a)
-- 36
  • 63 (a)
-- 36
  • 66 (a)
-- 36
  • 65 (a)
-- 36
  • 65 (a)
-- 36
  • 64 (a)
-- 36
  • 65 (a)
-- 36
  • 64 (a)
-- 36
  • 64 (a)
-- 36
  • 64 (a)
-- 36
  • 65 (a)
-- 36
  • 66 (a)
-- 36
  • 63 (a)
-- 36
  • 55 (a)
  • 64 (a)
  • 59 (a)
IFNW1 36
  • 63 (a)
(Pan troglodytes)
Mammalia IFNW1 35
  • 99.32 (n)
  • 98.97 (a)
IFNW1 36
  • 97 (a)
Species with no ortholog for IFNW1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNW1 Gene

Gene Tree for IFNW1 (if available)
Gene Tree for IFNW1 (if available)

Paralogs for IFNW1 Gene

(19) SIMAP similar genes for IFNW1 Gene using alignment to 1 proteins: Pseudogenes for IFNW1 Gene

genes like me logo Genes that share paralogs with IFNW1: view

Variants for IFNW1 Gene

Sequence variations from dbSNP and Humsavar for IFNW1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2230055 - 21,141,288(-) CAGAG(A/C/T)GCTCC reference, missense
rs114888928 -- 21,142,306(+) TGTGC(A/C)TCAGC upstream-variant-2KB
rs116056862 -- 21,143,190(+) GGTCA(A/G)TAGTG upstream-variant-2KB
rs116160798 -- 21,140,150(+) ATTTC(A/T)TGTCT downstream-variant-500B
rs116190330 -- 21,140,200(+) TCAAC(A/G)TCATT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IFNW1 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892733 CNV Gain 21882294
nsv892734 CNV Gain 21882294

Variation tolerance for IFNW1 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.89% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IFNW1 Gene

Disorders for IFNW1 Gene

Relevant External Links for IFNW1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IFNW1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNW1 Gene

Publications for IFNW1 Gene

  1. Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein. (PMID: 1647209) Adolf G.R. … Zoephel A. (Biochim. Biophys. Acta 1991) 3 4 23 67
  2. Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes. (PMID: 16504056) Morris G.A. … Todd J.A. (BMC Genet. 2006) 3 23
  3. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  4. Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase. (PMID: 1693148) Adolf G.R. … Cantell K. (J. Biol. Chem. 1990) 3 23
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for IFNW1 Gene

Sources for IFNW1 Gene