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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNW1 Gene

protein-coding   GIFtS: 55
GCID: GC09M021103

Interferon, Omega 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Omega 11 2
Interferon Omega-11 2
Interferon Alpha-II-12 3
IFN-Omega 11
IFN-Omega 1, Interferon Omega-12

External Ids:    HGNC: 54481   Entrez Gene: 34672   Ensembl: ENSG000001770477   OMIM: 1475535   UniProtKB: P050003   

Export aliases for IFNW1 gene to outside databases

Previous GC identifers: GC09M021468 GC09M021341 GC09M021130


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFNW1 Gene: 
IFNW1 (interferon, omega 1) is a protein-coding gene. Diseases associated with IFNW1 include dengue hemorrhagic fever, and hemorrhagic fever, and among its related super-pathways are NOD-like Receptor Signaling Pathways and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include cytokine receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

Gene Wiki entry for IFNW1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFNW1 gene promoter:
         SRF   COUP-TF1   SRF (504 AA)   COUP   CUTL1   HNF-4alpha2   HNF-4alpha1   HEN1   S8   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNW1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFNW1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNW1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNW1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021103:  view genomic region     (about GC identifiers)

Start:
21,140,631 bp from pter      End:
21,142,144 bp from pter
Size:
1,514 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFNW1_HUMAN, P05000 (See protein sequence)
Recommended Name: Interferon omega-1 precursor  
Size: 195 amino acids; 22319 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for IFNW1:
3SE4 (3D)    
Secondary accessions: Q13168 Q5U802 Q5VWD0 Q7M4P5

Explore the universe of human proteins at neXtProt for IFNW1: NX_P05000

Explore proteomics data for IFNW1 at MOPED 

IFNW1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IFNW1 Protein Expression

REFSEQ proteins: NP_002168.1  
ENSEMBL proteins: 
 ENSP00000369578  

Human Recombinant Protein Products for IFNW1: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--

IFNW1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IFN: Interferons

3 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR000471 Interferon_alpha/beta/delta
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P05000

ProtoNet protein and cluster: P05000

1 Blocks protein domain: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNW1_HUMAN, P05000
Similarity: Belongs to the alpha/beta interferon family


IFNW1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for IFNW1:
interferon type I,omega 1,leukocyte

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005126cytokine receptor binding IEA--
     
IFNW1 for ontologies           About GeneDecksing


Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidIFNW1 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNW1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IFNW1 About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Toll-Like receptor Signaling Pathways
Toll-Like receptor Signaling Pathways0.59
NOD-like Receptor Signaling Pathways0.59
2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIG-I-like receptor signaling pathway0.52
3PEDF Induced Signaling
Cytokine-cytokine receptor interaction0.43
4all-trans-Retinoic Acid Mediated Apoptosis
all-trans-Retinoic Acid Mediated Apoptosis
5Jak-STAT signaling pathway
Jak-STAT signaling pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 R&D Systems Pathways for IFNW1
    NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNW1
    Interferon Pathway
all-trans-Retinoic Acid Mediated Apoptosis



3         Kegg Pathways  (Kegg details for IFNW1):
    Cytokine-cytokine receptor interaction
RIG-I-like receptor signaling pathway
Jak-STAT signaling pathway


IFNW1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNW1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for IFNW1 (P050003 ENSP000003695784) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IFNAR1P171813, ENSP000002701394I2D: score=2 STRING: ENSP00000270139
IFNAR2ENSP000003439574STRING: ENSP00000343957
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006952defense response ----
GO:0007050cell cycle arrest TAS10835682
GO:0009615response to virus TAS1647209
GO:0051607defense response to virus IEA--

IFNW1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNW1

Search CenterWatch for drugs/clinical trials and news about IFNW1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNW1 gene: 
NM_002177.1  

Unigene Cluster for IFNW1:

Interferon, omega 1
Hs.73010
Unigene Representative Sequence: NM_002177
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000380229(uc003zol.1)
miRNA
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hsa-miR-374c hsa-miR-655
SwitchGear 3'UTR luciferase reporter plasmidIFNW1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IFNW1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNW1
Clone
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OriGene ORF clones in mouse, rat for IFNW1
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Sirion Biotech Customized lentivirus for stable overexpression of IFNW1 
                     Customized lentivirus expression plasmids for stable overexpression of IFNW1 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for IFNW1
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFNW1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNW1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNW1

Additional mRNA sequence: 

AY780805.1 BC069095.1 BC117290.1 BC117292.1 X02669.1 

1 DOTS entry:

DT.407287 

3 AceView cDNA sequences:

NM_002177 BC069095 X02669 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNW1 expression in normal human tissues (normalized intensities)      IFNW1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGACTCTGGT
IFNW1 Expression
About this image


IFNW1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles

See IFNW1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNW1

SOURCE GeneReport for Unigene cluster: Hs.73010
    SABiosciences Expression via Pathway-Focused PCR Arrays including IFNW1: 
          Interferons & Receptors in human mouse rat
          Type I Interferon Response in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNW1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNW1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IFNW1 gene from 1/2 species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ifnz5 interferon zeta   --   4 (42.03 cM) 88782131 


ENSEMBL Gene Tree for IFNW1 (if available)
TreeFam Gene Tree for IFNW1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IFNW1 gene
IFNA72  IFNA22  IFNA42  IFNE2  IFNA142  IFNA52  IFNK2  IFNA12  
IFNA212  IFNA172  IFNA62  IFNB12  IFNA132  IFNA162  IFNA102  IFNA82  
18/19 SIMAP similar genes for IFNW1 using alignment to 1 protein entry:     IFNW1_HUMAN(see all similar genes):
IFNA    IFNA10    IFNA17    IFNA2    IFNA8    IFNA21
IFNA2B    IFNA4    IFNA5    IFNA7    IFN-2    IFNA14
IFNA16    IFNA1    IFNA13    IFNA6    IFNB1    IFNE

IFNW1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for IFNW1
PGOHUM00000236408


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/116 SNPs in IFNW1 are shown (see all 116)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1161607981,2
F--21140149(+) ATTTCA/TTGTCT 1 -- ds50011Minor allele frequency- T:0.03WA 118
rs1161903301,2
C--21140199(+) TCAACA/GTCATT 1 -- ds50010--------
rs1462501911,2
--21140277(+) CGAAAC/TTGGTA 1 -- ds50010--------
rs1823113271,2
--21140430(+) GAGATA/GTTTTG 1 -- ds50010--------
rs109648591,2
C,F,H--21140672(+) TTTAAC/GCAAAT 1 -- ut3120Minor allele frequency- G:0.27NS EA NA WA CSA 2346
rs1393779721,2
C--21140678(+) CAAATC/GGAAAG 1 -- ut310--------
rs1441428701,2
C--21140711(+) ATACAA/GTGTAA 1 -- ut310--------
rs1857978901,2
--21140907(+) AAGCCA/GAAATA 1 -- ut310--------
rs283681291,2
C--21140944(-) ACTTGC/TACATG 1 -- ut31 ese30--------
rs2002111531,2
--21141020(+) CAGTCC/TTTCTT 2 R G mis10--------

HapMap Linkage Disequilibrium report for IFNW1 (21140631 - 21142144 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for IFNW1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv892724CNV Gain21882294
nsv892734CNV Gain21882294
nsv892733CNV Gain21882294

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147553    OMIM disorders: --

9 diseases for IFNW1:    About MalaCards
dengue hemorrhagic fever    hemorrhagic fever    narcolepsy    hepatitis c
type 1 diabetes    hepatitis b    hepatitis    dermatitis
melanoma


IFNW1 for disorders           About GeneDecksing

Genetic Association Database (GAD): IFNW1
Human Genome Epidemiology (HuGE) Navigator: IFNW1 (6 documents)

Export disorders for IFNW1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IFNW1 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with IFNW1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein. (PubMed id 1647209)1, 2, 9 Adolf G.R....Zoephel A. (1991)
  2. Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase. (PubMed id 1693148)1, 2, 9 Adolf G.R.... Cantell K. (1990)
  3. Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes. (PubMed id 16504056)1, 4, 9 Morris G.A....Todd J.A. (2006)
  4. Structural linkage between ligand discrimination and receptor activation by type I interferons. (PubMed id 21854986)1, 2 Thomas C....Garcia K.C. (2011)
  5. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
  6. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)
  7. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
  8. Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (2010)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3467 HGNC: 5448 AceView: IFNW1 Ensembl:ENSG00000177047 euGenes: HUgn3467
ECgene: IFNW1 Kegg: 3467 H-InvDB: IFNW1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IFNW1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IFNW1 gene:
Search GeneIP for patents involving IFNW1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category
(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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