IFNW1 Gene
protein-coding GIFtS: 53
GCID: GC09M021103
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interferon, omega 1
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Aliases
for IFNW1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon, Omega 11 2 | | Interferon Alpha-II-12 3 | | IFN-Omega 1, Interferon Omega-12 | | Interferon Omega-12 |
Export aliases for IFNW1 gene to outside databasesPrevious GC identifers: GC09M021468 GC09M021341 GC09M021130 |
Summaries
for IFNW1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for IFNW1
|
Genomic Views
for IFNW1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFNW1 gene promoter:
SRF COUP-TF1 SRF (504 AA) COUP CUTL1 HNF-4alpha2 HNF-4alpha1 HEN1 S8 COUP-TF
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFNW1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNW1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22IFNW1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M021103: view genomic region
(about GC identifiers)
Start:
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21,140,631 bp from pter |
End:
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21,142,144 bp from pter |
Size:
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1,514 bases |
Orientation:
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minus strand |
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Proteins
for IFNW1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFNW1_HUMAN, P05000 (See
protein sequence)Recommended Name: Interferon omega-1 precursor Size: 195 amino acids; 22319 Da
Subcellular location: Secreted
1 PDB 3D structure from  and Proteopedia  for IFNW1:3SE4 (3D)
Secondary accessions: Q13168 Q5U802 Q5VWD0 Q7M4P5Explore the universe of human proteins at neXtProt for IFNW1: NX_P05000
IFNW1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002168.1
ENSEMBL proteins: ENSP00000369578
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IEA | -- |
IFNW1 for ontologies About GeneDecksing
IFNW1 Antibody Products:
Assay Products for IFNW1: |
Protein
Domains /
Families
for IFNW1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFNW1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P05000ProtoNet protein and cluster: P05000 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFNW1_HUMAN, P05000Similarity: Belongs to the alpha/beta interferon family |
Function
for IFNW1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for IFNW1:interferon type I,omega 1,leukocyte
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNW1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNW1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNW1 (NM_002177) | |  | Sino Biological Human cDNA Clone for IFNW1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNW1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNW1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNW1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- | | GO:0005126 | cytokine receptor binding |
IEA | -- |
IFNW1 for ontologies About GeneDecksing
|
Pathways & Interactions
for IFNW1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | all-trans-Retinoic Acid Mediated Apoptosis | | | 2 | Interferon Pathway | | | 3 | Jak-STAT signaling pathway | | | 4 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | | | 5 | Toll-like receptor signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for IFNW1
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNW1
3 
Kegg Pathways (Kegg details for IFNW1):
IFNW1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNW1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for IFNW1 (P050003 ENSP000003695784) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
IFNW1 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFNW1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFNW1
Search CenterWatch for drugs/clinical trials and news about IFNW1
|
Transcripts
for IFNW1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFNW1 gene: NM_002177.1 Unigene Cluster for IFNW1: Interferon, omega 1 Hs.73010 Unigene Representative Sequence: NM_0021771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000380229(uc003zol.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNW1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNW1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IFNW1 (NM_002177) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNW1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNW1 |
Additional cDNA sequence: AY780805.1 BC069095.1 BC117290.1 BC117292.1 X02669.1 1 DOTS entry: DT.407287 3 AceView cDNA sequences: X02669 BC069095 NM_002177
GeneLoc Exon Structure
|
Expression
for IFNW1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFNW1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACTCTGGT
About this image
See IFNW1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNW1
SOURCE GeneReport for Unigene cluster: Hs.73010
SABiosciences Expression via Pathway-Focused PCR Arrays including IFNW1: | Interferons & Receptors in human mouse rat | | Type I Interferon Response in human mouse rat | | Inflammatory Response & Autoimmunity 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNW1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFNW1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNW1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNW1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNW1 |
Orthologs
for IFNW1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFNW1 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for IFNW1 (if available)
TreeFam Gene Tree for IFNW1 (if available) |
Paralogs
for IFNW1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IFNW1 gene
- IFNA72 IFNA22 IFNE2 IFNA42 IFNA142 IFNA52 IFNK2 IFNA12
- IFNA212 IFNA172 IFNA62 IFNB12 IFNA132 IFNA162 IFNA102 IFNA82
18/19 SIMAP similar genes for IFNW1 using alignment to 1 protein entry: IFNW1_HUMAN(see all similar genes):IFNA IFNA10 IFNA17 IFNA2 IFNA8 IFNA21
IFNA2B IFNA4 IFNA5 IFNA7 IFN-2 IFNA14
IFNA16 IFNA1 IFNA13 IFNA6 IFNB1 IFNE
IFNW1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IFNW1
PGOHUM00000236408
|
Genomic Variants
for IFNW1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFNW1 (21140631 - 21142144 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFNW1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNW1 |
|
Disorders
/ Diseases
for IFNW1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFNW1 for disorders About GeneDecksing
OMIM gene information: 147553
OMIM disorders: --
6  diseases for IFNW1: About MalaCardsdengue hemorrhagic fever hemorrhagic fever hepatitis c hepatitis b
hepatitis melanoma
Human Genome Epidemiology (HuGE) Navigator: IFNW1 (6 documents)
Export disorders for IFNW1 gene to outside databases
|
Publications
for IFNW1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFNW1 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with IFNW1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein. (PubMed id 1647209)1, 2, 9 Adolf G.R....Zoephel A. (1991)
- Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase. (PubMed id 1693148)1, 2, 9 Adolf G.R.... Cantell K. (1990)
- Structural linkage between ligand discrimination and receptor activation by type I interferons. (PubMed id 21854986)1, 2 Thomas C....Garcia K.C. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
- Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides. (PubMed id 2985969)1, 2 Capon D.J.... Goeddel D.V. (1985)
- A novel class of human type I interferons. (PubMed id 3895159)1, 2 Hauptmann R. and Swetly P. (1985)
- Cloning, sequencing and expression in E. coli of interferon-omega 1 gene. (PubMed id 8142025)2, 9 Li M.F.... Hou Y.D. (1993)
- Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes. (PubMed id 16504056)1, 9 Morris G.A....Todd J.A. (2006)
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External Searches for IFNW1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFNW1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFNW1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNW1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFNW1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IFNW1 gene:
Search GeneIP for patents involving IFNW1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFNW1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IFNW1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNW1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNW1 | | | OriGene Protein Over-expression Lysate for IFNW1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IFNW1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNW1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNW1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IFNW1 | | OriGene Custom Protein Services for IFNW1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNW1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNW1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNW1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNW1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNW1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNW1 |
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| |  |  |  |  | | | | | | Recombinant Protein for IFNW1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNW1 |
|  |  |  | | | | Search ThermoFisher Antibodies for IFNW1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNW1 |
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