Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IFNW1 Gene

Aliases for IFNW1 Gene

  • Interferon, Omega 1 2 3
  • Interferon Alpha-II-1 4
  • Interferon Omega-1 2
  • IFN-Omega 1 2

External Ids for IFNW1 Gene

Previous GeneCards Identifiers for IFNW1 Gene

  • GC09M021468
  • GC09M021341
  • GC09M021130

Summaries for IFNW1 Gene

Entrez Gene Summary for IFNW1 Gene

  • The protein encoded by this gene is an interferon and possesses antiviral activity. The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. This intronless gene has several pseudogenes spread throughout the genome. [provided by RefSeq, Nov 2015]

GeneCards Summary for IFNW1 Gene

IFNW1 (Interferon, Omega 1) is a Protein Coding gene. Among its related pathways are Interferon Pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

Gene Wiki entry for IFNW1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNW1 Gene

Genomics for IFNW1 Gene

Regulatory Elements for IFNW1 Gene

Genomic Location for IFNW1 Gene

Chromosome:
9
Start:
21,140,214 bp from pter
End:
21,142,145 bp from pter
Size:
1,932 bases
Orientation:
Minus strand

Genomic View for IFNW1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IFNW1 Gene

Proteins for IFNW1 Gene

  • Protein details for IFNW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05000-IFNW1_HUMAN
    Recommended name:
    Interferon omega-1
    Protein Accession:
    P05000
    Secondary Accessions:
    • Q13168
    • Q5U802
    • Q5VWD0
    • Q7M4P5

    Protein attributes for IFNW1 Gene

    Size:
    195 amino acids
    Molecular mass:
    22319 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IFNW1 Gene

neXtProt entry for IFNW1 Gene

Proteomics data for IFNW1 Gene at MOPED

Post-translational modifications for IFNW1 Gene

Other Protein References for IFNW1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNW1 Gene

Domains & Families for IFNW1 Gene

Gene Families for IFNW1 Gene

Suggested Antigen Peptide Sequences for IFNW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05000

UniProtKB/Swiss-Prot:

IFNW1_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNW1: view

Function for IFNW1 Gene

Molecular function for IFNW1 Gene

GENATLAS Biochemistry:
interferon type I,omega 1,leukocyte

Gene Ontology (GO) - Molecular Function for IFNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding TAS 1647209
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNW1: view

Phenotypes for IFNW1 Gene

genes like me logo Genes that share phenotypes with IFNW1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNW1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNW1 Gene

Localization for IFNW1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNW1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNW1 Gene COMPARTMENTS Subcellular localization image for IFNW1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNW1: view

Pathways & Interactions for IFNW1 Gene

genes like me logo Genes that share pathways with IFNW1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat

SIGNOR curated interactions for IFNW1 Gene

Activates:

Gene Ontology (GO) - Biological Process for IFNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNW1: view

Drugs & Compounds for IFNW1 Gene

No Compound Related Data Available

Transcripts for IFNW1 Gene

mRNA/cDNA for IFNW1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNW1 Gene

Interferon, omega 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNW1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNW1 Gene

No ASD Table

Relevant External Links for IFNW1 Gene

GeneLoc Exon Structure for
IFNW1
ECgene alternative splicing isoforms for
IFNW1

Expression for IFNW1 Gene

mRNA expression in normal human tissues for IFNW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFNW1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.3) and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for IFNW1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFNW1 Gene



SOURCE GeneReport for Unigene cluster for IFNW1 Gene Hs.73010

genes like me logo Genes that share expression patterns with IFNW1: view

Protein tissue co-expression partners for IFNW1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IFNW1 Gene

Orthologs for IFNW1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNW1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100336885 35
  • 79.21 (n)
  • 67.53 (a)
-- 36
  • 65 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
IFN-TAU 36
  • 64 (a)
OneToMany
IFNT 36
  • 59 (a)
OneToMany
IFNW1 36
  • 63 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia IFNW1 35
  • 99.32 (n)
  • 98.97 (a)
IFNW1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifnz 16
Species with no ortholog for IFNW1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNW1 Gene

ENSEMBL:
Gene Tree for IFNW1 (if available)
TreeFam:
Gene Tree for IFNW1 (if available)

Paralogs for IFNW1 Gene

(19) SIMAP similar genes for IFNW1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFNW1 Gene

genes like me logo Genes that share paralogs with IFNW1: view

Variants for IFNW1 Gene

Sequence variations from dbSNP and Humsavar for IFNW1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2230055 - 21,141,288(-) CAGAG(A/C/T)GCTCC missense, reference
rs3750476 -- 21,141,373(+) CCTTT(C/T)ACCAT reference, synonymous-codon
rs5896925 -- 21,142,274(+) CAGCC(-/T)TTTAA upstream-variant-2KB
rs7023569 -- 21,144,072(+) tcctg(A/T)atggt upstream-variant-2KB
rs10511694 -- 21,143,021(-) AGGTC(A/G)CCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNW1 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892733 CNV Gain 21882294
nsv892734 CNV Gain 21882294

Variation tolerance for IFNW1 Gene

Residual Variation Intolerance Score: 87.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNW1 Gene

HapMap Linkage Disequilibrium report
IFNW1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNW1 Gene

Disorders for IFNW1 Gene

Relevant External Links for IFNW1

Genetic Association Database (GAD)
IFNW1
Human Genome Epidemiology (HuGE) Navigator
IFNW1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNW1
genes like me logo Genes that share disorders with IFNW1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNW1 Gene

Publications for IFNW1 Gene

  1. Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes. (PMID: 16504056) Morris G.A. … Todd J.A. (BMC Genet. 2006) 23 67
  2. Liposomal plasmid DNA encoding human thymosin alpha and interferon omega potently inhibits liver tumor growth in ICR mice. (PMID: 16928214) Chen P.F. … Hou Y.Y. (J. Gastroenterol. Hepatol. 2006) 23 67
  3. Cloning, sequencing and expression in E. coli of interferon-omega 1 gene. (PMID: 8142025) Li M.F. … Hou Y.D. (Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 1993) 23 67
  4. Expression of human interferon omega 1 in Sf9 cells. No evidence for complex-type N-linked glycosylation or sialylation. (PMID: 8223648) Voss T. … GlAPssl J. (Eur. J. Biochem. 1993) 23 67
  5. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 67

Products for IFNW1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNW1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNW1
  • Block miRNA regulation of IFNW1 using miScript Target Protectors

Sources for IFNW1 Gene

Back to Top

Content