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Aliases for IFNLR1 Gene

Aliases for IFNLR1 Gene

  • Interferon Lambda Receptor 1 2 3 5
  • Interleukin 28 Receptor, Alpha (Interferon, Lambda Receptor) 2 3
  • Likely Interleukin Or Cytokine Receptor 2 3 4
  • Interleukin-28 Receptor Subunit Alpha 3 4
  • Cytokine Receptor Class-II Member 12 3 4
  • Cytokine Receptor Family 2 Member 12 3 4
  • IL-28 Receptor Subunit Alpha 3 4
  • IFN-Lambda Receptor 1 3 4
  • IFN-Lambda-R1 3 4
  • IL-28R-Alpha 3 4
  • CRF2-12 3 4
  • IL-28RA 3 4
  • IL28RA 3 4
  • LICR2 3 4
  • Class II Cytokine Receptor CRF2/12 3
  • Interleukin Or Cytokine Receptor 2 3
  • Interleukin 28 Receptor, Alpha 2
  • Interferon, Lambda Receptor 1 2
  • Interleukin 28 Alpha Receptor 3
  • Interleukin 28 Receptor A 3
  • CRF2/12 3
  • IL-28R1 3
  • IFNLR 3

External Ids for IFNLR1 Gene

Previous HGNC Symbols for IFNLR1 Gene

  • IL28RA

Previous GeneCards Identifiers for IFNLR1 Gene

  • GC01M024481

Summaries for IFNLR1 Gene

Entrez Gene Summary for IFNLR1 Gene

  • The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNLR1 Gene

IFNLR1 (Interferon Lambda Receptor 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Type III Interferon Signaling Pathways. GO annotations related to this gene include cytokine receptor activity.

UniProtKB/Swiss-Prot for IFNLR1 Gene

  • The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Gene Wiki entry for IFNLR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNLR1 Gene

Genomics for IFNLR1 Gene

Regulatory Elements for IFNLR1 Gene

Enhancers for IFNLR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G024188 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23.2 -3.1 -3082 4.9 HDGF PKNOX1 ZNF133 SIN3A YY1 ZNF121 ZNF766 FOS NFYC JUNB IFNLR1 LOC284632 GRHL3 IL22RA1 PNRC2
GH01G024149 1.5 FANTOM5 Ensembl ENCODE 29 +36.6 36584 3.8 ATF1 ARID4B GATA2 ZNF143 FOS ZNF263 SP3 YY2 NFYC REST IFNLR1 GRHL3 MYOM3 LOC105376871 NCMAP IL22RA1 PNRC2 GC01P024177
GH01G024183 1.2 ENCODE dbSUPER 23.7 +1.9 1923 4.6 ARID4B FEZF1 DMAP1 YY1 ZNF121 GLIS2 ZNF263 SP3 NFYC CBX8 IFNLR1 LOC284632 GC01P024177
GH01G024390 1.5 Ensembl ENCODE dbSUPER 11.7 -204.6 -204618 3.4 HDGF WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 FOS SP5 STPG1 NIPAL3 IFNLR1 GRHL3 LOC105376871 NCMAP PIR44101
GH01G024115 1.5 Ensembl ENCODE dbSUPER 5.5 +68.8 68843 6.2 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF121 GLIS2 FOS ZMIZ1 SP5 MYOM3 IL22RA1 GRHL3 LOC105376871 NCMAP IFNLR1 PNRC2 GC01P024142
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFNLR1 on UCSC Golden Path with GeneCards custom track

Promoters for IFNLR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003154 659 1001 ELF3 INSM2 FEZF1 RARA YY1 GLIS2 ZNF391 CREM EGR2 SP3

Genomic Location for IFNLR1 Gene

Chromosome:
1
Start:
24,154,157 bp from pter
End:
24,187,959 bp from pter
Size:
33,803 bases
Orientation:
Minus strand

Genomic View for IFNLR1 Gene

Genes around IFNLR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNLR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNLR1 Gene

Proteins for IFNLR1 Gene

  • Protein details for IFNLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU57-INLR1_HUMAN
    Recommended name:
    Interferon lambda receptor 1
    Protein Accession:
    Q8IU57
    Secondary Accessions:
    • Q5VTX5
    • Q5VTX7
    • Q5VTX8
    • Q6ZML8
    • Q8IV66
    • Q8IZI7
    • Q8IZI8

    Protein attributes for IFNLR1 Gene

    Size:
    520 amino acids
    Molecular mass:
    57653 Da
    Quaternary structure:
    • Heterodimer with IL10RB.
    SequenceCaution:
    • Sequence=BAD18707.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IFNLR1 Gene

    Alternative splice isoforms for IFNLR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFNLR1 Gene

Post-translational modifications for IFNLR1 Gene

  • Glycosylation at isoforms=2, 3, 429, posLast=3636, posLast=142142, and posLast=169169
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IFNLR1 Gene

Domains & Families for IFNLR1 Gene

Gene Families for IFNLR1 Gene

Protein Domains for IFNLR1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IU57

UniProtKB/Swiss-Prot:

INLR1_HUMAN :
  • Belongs to the type II cytokine receptor family.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IFNLR1: view

Function for IFNLR1 Gene

Molecular function for IFNLR1 Gene

UniProtKB/Swiss-Prot Function:
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Gene Ontology (GO) - Molecular Function for IFNLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 contributes_to cytokine receptor activity NAS,IBA 12483210
GO:0005515 protein binding IPI 12469119
genes like me logo Genes that share ontologies with IFNLR1: view
genes like me logo Genes that share phenotypes with IFNLR1: view

Animal Models for IFNLR1 Gene

MGI Knock Outs for IFNLR1:

Animal Model Products

CRISPR Products

miRNA for IFNLR1 Gene

miRTarBase miRNAs that target IFNLR1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNLR1 Gene

Localization for IFNLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNLR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNLR1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFNLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 12483210
GO:0032002 interleukin-28 receptor complex IDA 12469119
genes like me logo Genes that share ontologies with IFNLR1: view

Pathways & Interactions for IFNLR1 Gene

genes like me logo Genes that share pathways with IFNLR1: view

Pathways by source for IFNLR1 Gene

SIGNOR curated interactions for IFNLR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IFNLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002385 mucosal immune response ISS --
GO:0008285 negative regulation of cell proliferation NAS 12469119
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0034342 response to type III interferon ISS --
GO:0050691 regulation of defense response to virus by host IDA 12469119
genes like me logo Genes that share ontologies with IFNLR1: view

Drugs & Compounds for IFNLR1 Gene

(1) Drugs for IFNLR1 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PEG-INTERFERON LAMBA Pharma 0
genes like me logo Genes that share compounds with IFNLR1: view

Transcripts for IFNLR1 Gene

Unigene Clusters for IFNLR1 Gene

Interferon, lambda receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNLR1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - -
SP7:

Relevant External Links for IFNLR1 Gene

GeneLoc Exon Structure for
IFNLR1
ECgene alternative splicing isoforms for
IFNLR1

Expression for IFNLR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of IFNLR1 Gene:

IFNLR1

SOURCE GeneReport for Unigene cluster for IFNLR1 Gene:

Hs.221375

mRNA Expression by UniProt/SwissProt for IFNLR1 Gene:

Q8IU57-INLR1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for IFNLR1 Gene

  • Spleen(4.2)
genes like me logo Genes that share expression patterns with IFNLR1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNLR1 Gene

Orthologs for IFNLR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNLR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL28RA 34
  • 99.23 (n)
IFNLR1 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL28RA 34
  • 80.8 (n)
IFNLR1 35
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFNLR1 34 35
  • 79.51 (n)
rat
(Rattus norvegicus)
Mammalia Ifnlr1 34
  • 73.62 (n)
mouse
(Mus musculus)
Mammalia Ifnlr1 34 16 35
  • 72.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IFNLR1 35
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IFNLR1 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves IFNLR1 35
  • 32 (a)
OneToOne
Species where no ortholog for IFNLR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNLR1 Gene

ENSEMBL:
Gene Tree for IFNLR1 (if available)
TreeFam:
Gene Tree for IFNLR1 (if available)

Paralogs for IFNLR1 Gene

(1) SIMAP similar genes for IFNLR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFNLR1: view

No data available for Paralogs for IFNLR1 Gene

Variants for IFNLR1 Gene

Sequence variations from dbSNP and Humsavar for IFNLR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000073414 -- 24,175,574(+) ACCTC(C/T)AGTCA intron-variant
rs1000080231 -- 24,171,129(+) TGTGC(C/T)TACTA intron-variant
rs1000400185 -- 24,177,544(+) CATCT(A/G)CCACC intron-variant
rs1000502823 -- 24,160,096(+) AGGTA(A/G)GGATA intron-variant
rs1000533888 -- 24,160,359(+) AAGAC(A/G)TAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFNLR1 Gene

Variant ID Type Subtype PubMed ID
dgv62n106 CNV deletion 24896259
nsv506923 OTHER sequence alteration 20534489
nsv6853 CNV insertion 18451855

Variation tolerance for IFNLR1 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNLR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNLR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNLR1 Gene

Disorders for IFNLR1 Gene

Relevant External Links for IFNLR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNLR1

No disorders were found for IFNLR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNLR1 Gene

Publications for IFNLR1 Gene

  1. Crystal structure of human interferon-lambda1 in complex with its high-affinity receptor interferon-lambdaR1. (PMID: 20934432) Miknis Z.J. … Wlodawer A. (J. Mol. Biol. 2010) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PMID: 12469119) Sheppard P. … Klucher K.M. (Nat. Immunol. 2003) 3 4 64
  4. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PMID: 12483210) Kotenko S.V. … Donnelly R.P. (Nat. Immunol. 2003) 3 4 64
  5. Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3. (PMID: 12521379) Dumoutier L. … Renauld J.-C. (Biochem. J. 2003) 3 4 64

Products for IFNLR1 Gene

Sources for IFNLR1 Gene

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