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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNLR1 Gene

protein-coding   GIFtS: 49
GCID: GC01M024481

Interferon, Lambda Receptor 1

(Previous names: interleukin 28 receptor, alpha, interleukin 28 receptor,...)
(Previous symbol: IL28RA)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Lambda Receptor 11 2     LICR22 3
IL28RA1 2 3 5     IFN-Lambda Receptor 12 3
Interleukin 28 Receptor, Alpha (Interferon, Lambda Receptor)1 2     IL-28 Receptor Subunit Alpha2 3
Interferon Lambda Receptor 11 2     Interleukin 28 Receptor, Alpha1
Cytokine Receptor Class-II Member 122 3     CRF2/122
Cytokine Receptor Family 2 Member 122 3     IFNLR2
Interleukin-28 Receptor Subunit Alpha2 3     IL-28R12
Likely Interleukin Or Cytokine Receptor 22 3     Class II Cytokine Receptor CRF2/122
CRF2-122 3     Interferon Lambda, Receptor 12
IFN-lambda-R12 3     Interleukin 28 Alpha Receptor2
IL-28R-alpha2 3     Interleukin 28 Receptor A2
IL-28RA2 3     Interleukin Or Cytokine Receptor 22

External Ids:    HGNC: 185841   Entrez Gene: 1637022   Ensembl: ENSG000001854367   OMIM: 6074045   UniProtKB: Q8IU573   

Export aliases for IFNLR1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNLR1 Gene:
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor
complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three
closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29).
The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein
have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three
alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Jul
2008)

GeneCards Summary for IFNLR1 Gene: 
IFNLR1 (interferon, lambda receptor 1) is a protein-coding gene. Diseases associated with IFNLR1 include cblc, and vaginitis, and among its related super-pathways are STAT3 Pathway. GO annotations related to this gene include cytokine receptor activity and protein binding.

UniProtKB/Swiss-Prot: INLR1_HUMAN, Q8IU57
Function: The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to
signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal
infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant
role in the antiviral immune defense in the intestinal epithelium

Gene Wiki entry for IFNLR1 (Interleukin 28 receptor, alpha subunit) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IFNLR1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IFNLR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNLR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

IFNLR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNLR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M024481:  view genomic region     (about GC identifiers)

Start:
24,480,647 bp from pter      End:
24,514,449 bp from pter
Size:
33,803 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INLR1_HUMAN, Q8IU57 (See protein sequence)
Recommended Name: Interferon lambda receptor 1 precursor  
Size: 520 amino acids; 57653 Da
Subunit: Heterodimer with IL10RB
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Sequence caution: Sequence=BAD18707.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for IFNLR1:
3OG4 (3D)        3OG6 (3D)    
Secondary accessions: Q5VTX5 Q5VTX7 Q5VTX8 Q6ZML8 Q8IV66 Q8IZI7 Q8IZI8
Alternative splicing: 4 isoforms:  Q8IU57-1   Q8IU57-2   Q8IU57-3   Q8IU57-4   

Explore the universe of human proteins at neXtProt for IFNLR1: NX_Q8IU57

Explore proteomics data for IFNLR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IU57

  • IFNLR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFNLR1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_734464.1  NP_775087.1  NP_775088.1  

    ENSEMBL proteins: 
     ENSP00000327824   ENSP00000328994   ENSP00000363542   ENSP00000363540   ENSP00000363539  

    Human Recombinant Protein Products for IFNLR1: 
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    Novus Biologicals IFNLR1 Protein
    Novus Biologicals IFNLR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane NAS12483210
    GO:0032002interleukin-28 receptor complex IDA12469119

    IFNLR1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFN: Interferons

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interferon-λ receptor 1 
    IL-10 receptor family

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8IU57

    ProtoNet protein and cluster: Q8IU57

    UniProtKB/Swiss-Prot: INLR1_HUMAN, Q8IU57
    Similarity: Belongs to the type II cytokine receptor family
    Similarity: Contains 1 fibronectin type-III domain


    IFNLR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INLR1_HUMAN, Q8IU57
    Function: The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to
    signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal
    infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant
    role in the antiviral immune defense in the intestinal epithelium

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004896contributes to cytokine receptor activity NAS12483210
    GO:0005515protein binding IPI12469119
         
    IFNLR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ifnlr1):
     immune system 

    IFNLR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ifnlr1tm1Palu for IFNLR1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNLR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNLR1

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFNLR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    2Type III interferon signaling
    Type III interferon signaling
    3Jak-STAT signaling pathway
    Jak-STAT signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for IFNLR1
        Type III interferon signaling


    2         Kegg Pathways  (Kegg details for IFNLR1):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    IFNLR1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNLR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/20 Interacting proteins for IFNLR1 (Q8IU573 ENSP000003278244) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFNL1Q8IU543, ENSP000003299914I2D: score=1 STRING: ENSP00000329991
    IFNL2Q8IZJ03, ENSP000003336394I2D: score=1 STRING: ENSP00000333639
    NAA38O957773, ENSP000002492994I2D: score=4 STRING: ENSP00000249299
    IL10RBENSP000002902004STRING: ENSP00000290200
    C1orf51ENSP000002903634STRING: ENSP00000290363
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation NAS12469119
    GO:0019221cytokine-mediated signaling pathway NAS12483210
    GO:0050691regulation of defense response to virus by host IDA12469119
    GO:0051607defense response to virus IEA--

    IFNLR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFNLR1 (INLR1)

    Search CenterWatch for drugs/clinical trials and news about IFNLR1 / INLR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFNLR1 gene (3 alternative transcripts): 
    NM_170743.3  NM_173064.2  NM_173065.2  

    Unigene Cluster for IFNLR1:

    Interferon, lambda receptor 1
    Hs.221375  [show with all ESTs]
    Unigene Representative Sequence: NM_170743
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327535(uc001bir.3 uc001bis.3 uc001bit.3 uc001biu.3)
    ENST00000327575 ENST00000374421 ENST00000374419 ENST00000374418(uc001biv.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF439325.1 AJ534330.1 AJ534331.1 AK160364.1 AY129151.1 AY129152.1 BC101407.1 BC101408.1 
    BC101975.1 BC139722.1 BC140872.1 JN591376.1 

    6 DOTS entries:

    DT.100020440  DT.100020441  DT.121370319  DT.97778190  DT.100830153  DT.40113429 

    24/27 AceView cDNA sequences (see all 27):

    AJ534331 AY129153 AY129151 NM_170743 BX324315 AY129152 AF439325 AJ534330 
    NM_173065 BQ061188 NM_173064 BU726266 BX324314 BQ956554 BX354040 BE244935 
    AK160364 BU940577 BX110994 BF434748 AI052197 BU622129 BU430530 AW340139 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IFNLR1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                                                  -                                             
    SP2:                                                  -                       -                     
    SP3:                          -                       -                                             
    SP4:                                                  -                 -                           
    SP5:        -     -     -                             -                                             


    ECgene alternative splicing isoforms for IFNLR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFNLR1 expression in normal human tissues (normalized intensities)      IFNLR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IFNLR1 Expression
    About this image


    IFNLR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)

    See IFNLR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFNLR1

    SOURCE GeneReport for Unigene cluster: Hs.221375

    UniProtKB/Swiss-Prot: INLR1_HUMAN, Q8IU57
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNLR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFNLR1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifnlr15
    Il28ra1
    interleukin 28 receptor alpha1, 5 73.61(n)1
    61.67(a)1
      4 (67.94 cM)5
    2427001  NM_174851.31  NP_777276.31 
     1356862875 
    chicken
    (Gallus gallus)
    Aves IL28RA1 interleukin 28 receptor, alpha (interferon, lambda more 49.11(n)
    34.78(a)
      419694  XM_417841.1  XP_417841.1 


    ENSEMBL Gene Tree for IFNLR1 (if available)
    TreeFam Gene Tree for IFNLR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFNLR1 gene
    1 SIMAP similar gene for IFNLR1 using alignment to 2 protein entries:     INLR1_HUMAN (see all proteins):
    IL28RA

    IFNLR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/921 SNPs in IFNLR1 are shown (see all 921)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824563361,2
    --24480151(+) CTCCCG/TGGTTC 3 -- ds50010--------
    rs120694471,2
    C,F,A--24480206(+) tcgccC/Tgccac 3 -- ds50013Minor allele frequency- T:0.50NA WA 6
    rs1457821231,2
    --24480209(+) CCCGCC/TACCAC 3 -- ds50010--------
    rs1884556461,2
    --24480272(+) CAGGAC/TGGTCT 3 -- ds50010--------
    rs120270231,2
    C--24480304(+) TGCCCG/ACCTCG 3 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1915477181,2
    --24480308(+) CGCCTC/TGGCCT 3 -- ds50010--------
    rs340472871,2
    C,F--24480436(+) GAAACG/AGTCAC 3 -- ds50014Minor allele frequency- A:0.03NA 126
    rs1837204961,2
    --24480454(+) TATAAC/TCCCAA 3 -- ds50010--------
    rs1885999691,2
    --24480477(+) GAGGCC/TGAGGC 3 -- ds50010--------
    rs1470957861,2
    --24480597(+) GACAGA/GGTGAG 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for IFNLR1 (24480647 - 24514449 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IFNLR1: --

    Human Gene Mutation Database (HGMD): IFNLR1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNLR1
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNLR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607404    OMIM disorders: --

    10 diseases for IFNLR1:    About MalaCards
    cblc    vaginitis    allergic rhinitis    rhinitis
    dementia    multiple sclerosis    hepatitis b    melanoma
    hepatitis    neuronitis


    IFNLR1 for disorders           About GeneDecksing


    Export disorders for IFNLR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFNLR1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with IFNLR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human interferon-lambda1 in complex with its high-affinity receptor interferon-lambdaR1. (PubMed id 20934432)1, 2 Miknis Z.J....Wlodawer A. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3. (PubMed id 12521379)1, 2 Dumoutier L.... Renauld J.-C. (2003)
    4. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PubMed id 12483210)1, 2 Kotenko S.V.... Donnelly R.P. (2003)
    5. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PubMed id 12469119)1, 2 Sheppard P.... Klucher K.M. (2003)
    6. IL28RA polymorphism is associated with early hepatitis C virus (HCV) treatment failure in human immunodeficiency virus-/HCV-coinfected patients. (PubMed id 23565619)1 Jimenez-Sousa M.A....Resino S. (2013)
    7. Type III IFNs are produced by and stimulate human plas macytoid dendritic cells. (PubMed id 22891284)1 Yin Z....Fitzgerald-Bocarsly P. (2012)
    8. Analysis of the IL28RA locus as genetic risk factor fo r multiple sclerosis. (PubMed id 22386267)1 Lopez de Lapuente A....Vandenbroeck K. (2012)
    9. Genetic variation in IL28RA is associated with the out comes of HCV infection in a high-risk Chinese population. (PubMed id 21742059)1 Cui Q....Yu R.B. (2011)
    10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 163702 HGNC: 18584 AceView: IL28RA Ensembl:ENSG00000185436 euGenes: HUgn163702
    ECgene: IFNLR1 Kegg: 163702 H-InvDB: IFNLR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFNLR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFNLR1 gene:
    Search GeneIP for patents involving IFNLR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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