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Aliases for IFNL4 Gene

Aliases for IFNL4 Gene

  • Interferon, Lambda 4 (Gene/Pseudogene) 2 3 5
  • IFN-Lambda-4 3 4
  • IFNAN 3

External Ids for IFNL4 Gene

Previous GeneCards Identifiers for IFNL4 Gene

  • GC19U901613
  • GC19M039737

Summaries for IFNL4 Gene

GeneCards Summary for IFNL4 Gene

IFNL4 (Interferon, Lambda 4 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with IFNL4 include response to antiviral treatment in hepatitis c and hepatitis c virus. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IFNL4 Gene

  • Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNL4 Gene

Genomics for IFNL4 Gene

Genomic Location for IFNL4 Gene

Chromosome:
19
Start:
39,246,314 bp from pter
End:
39,248,856 bp from pter
Size:
2,543 bases
Orientation:
Minus strand

Genomic View for IFNL4 Gene

Genes around IFNL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNL4 Gene

No data available for Regulatory Elements for IFNL4 Gene

Proteins for IFNL4 Gene

  • Protein details for IFNL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    K9M1U5-IFNL4_HUMAN
    Recommended name:
    Interferon lambda-4
    Protein Accession:
    K9M1U5
    Secondary Accessions:
    • K9M1A5
    • K9M269
    • K9M2P7

    Protein attributes for IFNL4 Gene

    Size:
    179 amino acids
    Molecular mass:
    19675 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IFNL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFNL4 Gene

Proteomics data for IFNL4 Gene at MOPED

Post-translational modifications for IFNL4 Gene

No Post-translational modifications

Other Protein References for IFNL4 Gene

No data available for DME Specific Peptides for IFNL4 Gene

Domains & Families for IFNL4 Gene

Protein Domains for IFNL4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

K9M1U5

UniProtKB/Swiss-Prot:

IFNL4_HUMAN :
  • Belongs to the lambda interferon family.
Family:
  • Belongs to the lambda interferon family.
genes like me logo Genes that share domains with IFNL4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for IFNL4 Gene

Function for IFNL4 Gene

Molecular function for IFNL4 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes.
UniProtKB/Swiss-Prot Induction:
Up-regulated by polyinosinic:polycytidylic acid (polyI:C) which mimics the double-stranded hepatitis C virus.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNL4 Gene

Localization for IFNL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNL4 Gene

Cytoplasm. Secreted.

Gene Ontology (GO) - Cellular Components for IFNL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23291588
genes like me logo Genes that share ontologies with IFNL4: view

No data available for Subcellular locations from COMPARTMENTS for IFNL4 Gene

Pathways & Interactions for IFNL4 Gene

SuperPathways for IFNL4 Gene

No Data Available

Interacting Proteins for IFNL4 Gene

Gene Ontology (GO) - Biological Process for IFNL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007259 JAK-STAT cascade IEA --
GO:0042502 tyrosine phosphorylation of Stat2 protein IDA 23291588
GO:0050778 positive regulation of immune response IEA --
GO:0050863 regulation of T cell activation IBA --
genes like me logo Genes that share ontologies with IFNL4: view

No data available for Pathways by source and SIGNOR curated interactions for IFNL4 Gene

Drugs & Compounds for IFNL4 Gene

(10) Drugs for IFNL4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2a Approved, Investigational Pharma 537
Peginterferon alfa-2b Approved Pharma 299
Ribavirin Approved Pharma 948
Simeprevir Approved Pharma 89
Sofosbuvir Approved Pharma 196
genes like me logo Genes that share compounds with IFNL4: view

Transcripts for IFNL4 Gene

mRNA/cDNA for IFNL4 Gene

(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNL4 Gene

No ASD Table

Relevant External Links for IFNL4 Gene

GeneLoc Exon Structure for
IFNL4
ECgene alternative splicing isoforms for
IFNL4

Expression for IFNL4 Gene

mRNA expression in normal human tissues for IFNL4 Gene

SOURCE GeneReport for Unigene cluster for IFNL4 Gene Hs.745579

genes like me logo Genes that share expression patterns with IFNL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFNL4 Gene

Orthologs for IFNL4 Gene

Evolution for IFNL4 Gene

ENSEMBL:
Gene Tree for IFNL4 (if available)
TreeFam:
Gene Tree for IFNL4 (if available)

No data available for Orthologs for IFNL4 Gene

Paralogs for IFNL4 Gene

No data available for Paralogs for IFNL4 Gene

Variants for IFNL4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNL4 Gene

K9M1U5-IFNL4_HUMAN
Genetic variation in IFNL4 is associated with susceptibility to hepatitis C virus (HCV) infection [MIM:609532]. A one-base insertion, introducing a frameshift at position 22, results in inactivation of the gene in a majority of the population. That polymorphism is a good marker for predicting spontaneous HCV clearance and the response to treatment of chronic hepatitis C. Noteworthily, the allele producing a functional protein able to induce an antiviral response and to prevent HCV replication in cell cultures, is less frequent in human populations and is associated with impaired spontaneous clearance of HCV.

Sequence variations from dbSNP and Humsavar for IFNL4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12983038 -- 39,250,484(+) agttc(A/G)agacc upstream-variant-2KB
rs10853727 -- 39,249,823(+) AGGCA(C/T)GCTTA upstream-variant-2KB
rs62120528 -- 39,250,778(+) CCTGA(A/C)CAACA upstream-variant-2KB
rs66531907 -- 39,250,035(+) CCTCC(A/C)GGGTT upstream-variant-2KB
rs112490393 -- 39,249,098(+) TTGCT(C/T)CACCC upstream-variant-2KB

Relevant External Links for IFNL4 Gene

HapMap Linkage Disequilibrium report
IFNL4
Human Gene Mutation Database (HGMD)
IFNL4

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IFNL4 Gene

Disorders for IFNL4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IFNL4 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
response to antiviral treatment in hepatitis c
  • response to peg/ifn-ribavirin in hcv
hepatitis c virus
  • hepatitic c virus
hepatitis c
  • chronic hepatitis c
cytomegalovirus retinitis
- elite association - COSMIC cancer census association via MalaCards
Search IFNL4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFNL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNL4
genes like me logo Genes that share disorders with IFNL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNL4 Gene

Publications for IFNL4 Gene

  1. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. (PMID: 23291588) Prokunina-Olsson L. … O'Brien T.R. (Nat. Genet. 2013) 2 3 4 67
  2. Guarding the frontiers: the biology of type III interferons. (PMID: 26194286) Wack A. … Hartmann R. (Nat. Immunol. 2015) 3
  3. Interferon-I>4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burden. (PMID: 25577150) Lu Y.F. … Bradrick S.S. (Virology 2015) 3
  4. Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance. (PMID: 26186989) O'Brien T.R. … Prokunina-Olsson L. (J. Hepatol. 2015) 3
  5. Demographics, clinical characteristics, IFNL3- and IFNL4- polymorphisms in a cohort of hepatitis C patients from Puerto Rico. (PMID: 25563035) Morales-VA!squez L. … Torres E.A. (P R Health Sci J 2014) 3

Products for IFNL4 Gene

Sources for IFNL4 Gene

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