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Aliases for IFNL4 Gene

Aliases for IFNL4 Gene

  • Interferon Lambda 4 (Gene/Pseudogene) 2 3 5
  • IFN-Lambda-4 3 4
  • Interferon, Lambda 4 3
  • Interferon Lambda-4 3
  • IFNAN 3

External Ids for IFNL4 Gene

Previous GeneCards Identifiers for IFNL4 Gene

  • GC19U901613
  • GC19M039737

Summaries for IFNL4 Gene

Entrez Gene Summary for IFNL4 Gene

  • This gene is a polymorphic pseudogene which, in some humans, encodes the interferon (IFN) lambda 4 protein. Humans are polymorphic for the dinucleotide TT/deltaG allele. Compared to the ancestral state in non-human primates, the TT allele produces a frameshift in the coding region of this gene which is predicted to induce nonsense-mediated mRNA decay. This allele, and an allele in the first intron of this gene, have experienced a rapid increase in frequency and show indications of positive selection. The ancestral states of these alleles are associated with an impaired ability to clear hepatitis C virus. This gene, like other type III interferons (IFNs), interacts with the IFN lambda receptor complex (IFNLR) whose signaling is generally restricted to epithelial cells. This gene resides in a cluster of four type III IFN genes and at least two pseudogenes on chromosome 19q13.2. In general, interferons are produced in response to viral infection and block viral replication and propagation to uninfected cells by activating the JAK-STAT pathway and up-regulating antiviral genes. Multiple alternatively spliced transcripts have been described for this gene but their biological validity and protein coding status is still being ascertained. [provided by RefSeq, May 2017]

GeneCards Summary for IFNL4 Gene

IFNL4 (Interferon Lambda 4 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with IFNL4 include Hepatitis C Virus and Hepatitis C. Among its related pathways are Type III Interferon Signaling Pathways. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IFNL4 Gene

  • Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNL4 Gene

Genomics for IFNL4 Gene

Regulatory Elements for IFNL4 Gene

Enhancers for IFNL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G039252 0.6 ENCODE 0.7 -3.8 -3810 0.1 ZNF263 TAL1 FOXM1 TCF12 ARID1B NCOR1 ZKSCAN8 ZNF350 SP7 IFNL4 MSRB1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFNL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNL4 Gene

Chromosome:
19
Start:
39,246,314 bp from pter
End:
39,248,856 bp from pter
Size:
2,543 bases
Orientation:
Minus strand

Genomic View for IFNL4 Gene

Genes around IFNL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNL4 Gene

Proteins for IFNL4 Gene

  • Protein details for IFNL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    K9M1U5-IFNL4_HUMAN
    Recommended name:
    Interferon lambda-4
    Protein Accession:
    K9M1U5
    Secondary Accessions:
    • K9M1A5
    • K9M269
    • K9M2P7

    Protein attributes for IFNL4 Gene

    Size:
    179 amino acids
    Molecular mass:
    19675 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IFNL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFNL4 Gene

Post-translational modifications for IFNL4 Gene

No Post-translational modifications

Other Protein References for IFNL4 Gene

No data available for DME Specific Peptides for IFNL4 Gene

Domains & Families for IFNL4 Gene

Protein Domains for IFNL4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

K9M1U5

UniProtKB/Swiss-Prot:

IFNL4_HUMAN :
  • Belongs to the lambda interferon family.
Family:
  • Belongs to the lambda interferon family.
genes like me logo Genes that share domains with IFNL4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for IFNL4 Gene

Function for IFNL4 Gene

Molecular function for IFNL4 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes.
UniProtKB/Swiss-Prot Induction:
Up-regulated by polyinosinic:polycytidylic acid (polyI:C) which mimics the double-stranded hepatitis C virus.

Gene Ontology (GO) - Molecular Function for IFNL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IMP 23291588
genes like me logo Genes that share ontologies with IFNL4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNL4 Gene

Localization for IFNL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNL4 Gene

Cytoplasm. Secreted.

Gene Ontology (GO) - Cellular Components for IFNL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23291588
GO:0005737 cytoplasm IDA 23291588
genes like me logo Genes that share ontologies with IFNL4: view

No data available for Subcellular locations from COMPARTMENTS for IFNL4 Gene

Pathways & Interactions for IFNL4 Gene

genes like me logo Genes that share pathways with IFNL4: view

Pathways by source for IFNL4 Gene

1 R&D Systems pathway for IFNL4 Gene

Interacting Proteins for IFNL4 Gene

Gene Ontology (GO) - Biological Process for IFNL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007260 tyrosine phosphorylation of STAT protein IMP 23291588
GO:0045087 innate immune response IBA --
GO:0050778 positive regulation of immune response IEA --
GO:0050863 regulation of T cell activation IBA --
GO:0051607 defense response to virus IMP 23291588
genes like me logo Genes that share ontologies with IFNL4: view

No data available for SIGNOR curated interactions for IFNL4 Gene

Drugs & Compounds for IFNL4 Gene

(11) Drugs for IFNL4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
boceprevir Approved, Investigational Pharma 0
daclatasvir Approved Pharma 0
Ledipasvir Approved Pharma 107
Peginterferon alfa-2a Approved, Investigational Pharma 565
Peginterferon alfa-2b Approved Pharma 307
genes like me logo Genes that share compounds with IFNL4: view

Transcripts for IFNL4 Gene

mRNA/cDNA for IFNL4 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNL4 Gene

No ASD Table

Relevant External Links for IFNL4 Gene

GeneLoc Exon Structure for
IFNL4
ECgene alternative splicing isoforms for
IFNL4

Expression for IFNL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNL4 Gene:

IFNL4

SOURCE GeneReport for Unigene cluster for IFNL4 Gene:

Hs.745579
genes like me logo Genes that share expression patterns with IFNL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNL4 Gene

Orthologs for IFNL4 Gene

Evolution for IFNL4 Gene

ENSEMBL:
Gene Tree for IFNL4 (if available)
TreeFam:
Gene Tree for IFNL4 (if available)

No data available for Orthologs for IFNL4 Gene

Paralogs for IFNL4 Gene

Pseudogenes.org Pseudogenes for IFNL4 Gene

genes like me logo Genes that share paralogs with IFNL4: view

No data available for Paralogs for IFNL4 Gene

Variants for IFNL4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNL4 Gene

IFNL4_HUMAN-K9M1U5
Genetic variation in IFNL4 is associated with susceptibility to hepatitis C virus (HCV) infection [MIM:609532]. A one-base insertion, introducing a frameshift at position 22, results in inactivation of the gene in a majority of the population. That polymorphism is a good marker for predicting spontaneous HCV clearance and the response to treatment of chronic hepatitis C. Noteworthily, the allele producing a functional protein able to induce an antiviral response and to prevent HCV replication in cell cultures, is less frequent in human populations and is associated with impaired spontaneous clearance of HCV.

Sequence variations from dbSNP and Humsavar for IFNL4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12979860 drug-response 39,248,147(+) AGGCG(C/T)GAACC intron-variant
rs368234815 drug-response 39,248,514(+) GGGCC(G/TT)CTGCG nc-transcript-variant
rs1000085840 -- 39,248,277(+) GGGAC(C/T)GCGGG intron-variant
rs1001485874 -- 39,249,500(+) CCGCC(C/T)CAGCC upstream-variant-2KB
rs1001585285 -- 39,248,316(+) ACATA(A/G)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFNL4 Gene

Variant ID Type Subtype PubMed ID
nsv833830 CNV loss 17160897
nsv963046 CNV duplication 23825009

Relevant External Links for IFNL4 Gene

Human Gene Mutation Database (HGMD)
IFNL4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNL4

No data available for Variation tolerance for IFNL4 Gene

Disorders for IFNL4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IFNL4 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
hepatitis c
  • chronic hepatitis c
hepatitis
  • hepatitis a
genital herpes
  • genital herpes simplex
- elite association - COSMIC cancer census association via MalaCards
Search IFNL4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFNL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNL4
genes like me logo Genes that share disorders with IFNL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNL4 Gene

Publications for IFNL4 Gene

  1. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. (PMID: 23291588) Prokunina-Olsson L. … O'Brien T.R. (Nat. Genet. 2013) 2 3 4 64
  2. A Association of HLA-DQ and IFNL4 polymorphisms with susceptibility to hepatitis B virus infection and clearance. (PMID: 27236152) Fan J.H. … Guo J.J. (Ann Hepatol 2016) 3 64
  3. Interferon lambda and hepatitis C virus core protein polymorphisms associated with liver cancer. (PMID: 27035616) Moreira J.P. … Pinho J.R. (Virology 2016) 3 64
  4. Association of IFNL3 and IFNL4 polymorphisms with hepatitis C virus infection in a population from southeastern Brazil. (PMID: 26973228) de Seixas Santos Nastri A.C. … Pinho J.R. (Arch. Virol. 2016) 3 64
  5. Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-I> Expression. (PMID: 26896692) Ferraris P. … Dash S. (Am. J. Pathol. 2016) 3 64

Products for IFNL4 Gene

Sources for IFNL4 Gene

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