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Aliases for IFNL4 Gene

Aliases for IFNL4 Gene

  • Interferon, Lambda 4 (Gene/Pseudogene) 2 3
  • IFN-Lambda-4 3 4
  • Interferon Lambda-4 3
  • IFNAN 3

External Ids for IFNL4 Gene

Summaries for IFNL4 Gene

GeneCards Summary for IFNL4 Gene

IFNL4 (Interferon, Lambda 4 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with IFNL4 include response to antiviral treatment in hepatitis c and hepatitis c virus. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IFNL4 Gene

  • Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNL4 Gene

Genomics for IFNL4 Gene

Genomic Location for IFNL4 Gene

Start:
39,246,314 bp from pter
End:
39,248,856 bp from pter
Size:
2,543 bases
Orientation:
Minus strand

Genomic View for IFNL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNL4 Gene

No data available for Regulatory Elements for IFNL4 Gene

Proteins for IFNL4 Gene

  • Protein details for IFNL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    K9M1U5-IFNL4_HUMAN
    Recommended name:
    Interferon lambda-4
    Protein Accession:
    K9M1U5
    Secondary Accessions:
    • K9M1A5
    • K9M269
    • K9M2P7

    Protein attributes for IFNL4 Gene

    Size:
    179 amino acids
    Molecular mass:
    19675 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IFNL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFNL4 Gene

Proteomics data for IFNL4 Gene at MOPED

Post-translational modifications for IFNL4 Gene

No Post-translational modifications

Other Protein References for IFNL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNL4 Gene

Domains for IFNL4 Gene

Protein Domains for IFNL4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

K9M1U5

UniProtKB/Swiss-Prot:

IFNL4_HUMAN
Family:
  • Belongs to the lambda interferon family.:
    • K9M1U5
genes like me logo Genes that share domains with IFNL4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for IFNL4 Gene

Function for IFNL4 Gene

Molecular function for IFNL4 Gene

UniProtKB/Swiss-Prot Function: Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes.
UniProtKB/Swiss-Prot Induction: Up-regulated by polyinosinic:polycytidylic acid (polyI:C) which mimics the double-stranded hepatitis C virus.

Gene Ontology (GO) - Molecular Function for IFNL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IMP 23291588
genes like me logo Genes that share ontologies with IFNL4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNL4 Gene

Localization for IFNL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNL4 Gene

Cytoplasm. Secreted.

Gene Ontology (GO) - Cellular Components for IFNL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23291588
GO:0005737 cytoplasm IDA 23291588
genes like me logo Genes that share ontologies with IFNL4: view

No data available for Subcellular locations from COMPARTMENTS for IFNL4 Gene

Pathways for IFNL4 Gene

SuperPathways for IFNL4 Gene

No Data Available

Interacting Proteins for IFNL4 Gene

Gene Ontology (GO) - Biological Process for IFNL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042502 tyrosine phosphorylation of Stat2 protein IDA 23291588
GO:0042508 tyrosine phosphorylation of Stat1 protein IMP 23291588
GO:0050778 positive regulation of immune response IEA --
GO:0051607 defense response to virus IMP 23291588
genes like me logo Genes that share ontologies with IFNL4: view

No data available for Pathways by source for IFNL4 Gene

Compounds for IFNL4 Gene

(4) PharmGKB related drug/compound annotations for IFNL4 Gene

Drug/compound Annotation
peginterferon alfa-2a CA
peginterferon alfa-2b CA
ribavirin CA
telaprevir CA
genes like me logo Genes that share compounds with IFNL4: view

Transcripts for IFNL4 Gene

mRNA/cDNA for IFNL4 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNL4 Gene

No ASD Table

Relevant External Links for IFNL4 Gene

GeneLoc Exon Structure for
IFNL4
ECgene alternative splicing isoforms for
IFNL4

Expression for IFNL4 Gene

mRNA expression in normal human tissues for IFNL4 Gene

SOURCE GeneReport for Unigene cluster for IFNL4 Gene Hs.745579

genes like me logo Genes that share expressions with IFNL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for IFNL4 Gene

Orthologs for IFNL4 Gene

Evolution for IFNL4 Gene

ENSEMBL:
Gene Tree for IFNL4 (if available)
TreeFam:
Gene Tree for IFNL4 (if available)

No data available for Orthologs for IFNL4 Gene

Paralogs for IFNL4 Gene

No data available for Paralogs for IFNL4 Gene

Variants for IFNL4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNL4 Gene

K9M1U5-IFNL4_HUMAN
Genetic variation in IFNL4 is associated with susceptibility to hepatitis C virus (HCV) infection [MIM:609532]. A one-base insertion, introducing a frameshift at position 22, results in inactivation of the gene in a majority of the population. That polymorphism is a good marker for predicting spontaneous HCV clearance and the response to treatment of chronic hepatitis C. Noteworthily, the allele producing a functional protein able to induce an antiviral response and to prevent HCV replication in cell cultures, is less frequent in human populations and is associated with impaired spontaneous clearance of HCV

Sequence variations from dbSNP and Humsavar for IFNL4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1549928 -- 39,249,069(-) GTAGA(A/G)ACAGG upstream-variant-2KB
rs4803221 -- 39,248,489(+) TAGTG(C/G)GAGAG synonymous-codon, reference, nc-transcript-variant
rs4803222 -- 39,248,713(+) TGGGA(C/G)AGAGA utr-variant-5-prime, nc-transcript-variant
rs7254424 -- 39,249,542(+) attgc(A/G)cctgg upstream-variant-2KB
rs10853727 -- 39,249,823(+) AGGCA(C/T)GCTTA upstream-variant-2KB

Relevant External Links for IFNL4 Gene

HapMap Linkage Disequilibrium report
IFNL4
Human Gene Mutation Database (HGMD)
IFNL4

No data available for Structural Variations from Database of Genomic Variants (DGV) for IFNL4 Gene

Disorders for IFNL4 Gene

genes like me logo Genes that share disorders with IFNL4: view

No data available for UniProtKB/Swiss-Prot for IFNL4 Gene

Publications for IFNL4 Gene

  1. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. (PMID: 23291588) Prokunina-Olsson L. … O'Brien T.R. (Nat. Genet. 2013) 2 3 4
  2. Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. (PMID: 23420232) Duggal P. … Thomas D.L. (Ann. Intern. Med. 2013) 3
  3. Association of the IFNL4-I9G Allele With Impaired Spontaneous Clearance of Hepatitis C Virus. (PMID: 23956438) Aka P.V. … O'Brien T.R. (J. Infect. Dis. 2014) 3
  4. Polymorphisms of interferon-I>4 and IL28B - effects on treatment response to interferon/ribavirin in patients with chronic hepatitis C. (PMID: 24205831) StAottermayer A.F. … Ferenci P. (Aliment. Pharmacol. Ther. 2014) 3
  5. Role of IL28B for chronic hepatitis C treatment toward personalized medicine. (PMID: 24325405) Matsuura K. … Tanaka Y. (J. Gastroenterol. Hepatol. 2014) 3

Products for IFNL4 Gene

Sources for IFNL4 Gene

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