Aliases for IFNL3 Gene
External Ids for IFNL3 Gene
Previous HGNC Symbols for IFNL3 Gene
Previous GeneCards Identifiers for IFNL3 Gene
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
GeneCards Summary for IFNL3 Gene
IFNL3 (Interferon Lambda 3) is a Protein Coding gene. Diseases associated with IFNL3 include Hepatitis C Virus and Ifnl3-Related Altered Drug Metabolism. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Jak-STAT signaling pathway (KEGG). GO annotations related to this gene include receptor binding and cytokine activity. An important paralog of this gene is IFNL2.
UniProtKB/Swiss-Prot for IFNL3 Gene
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.