IFNL3 Gene
protein-coding GIFtS: 42
GCID: GC19M039735
|
|
Interferon, Lambda 3(Previous names: interleukin 28B, interleukin 28B (interferon, lambda 3))
(Previous symbol: IL28B)
| |
Aliases
for IFNL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Interferon, Lambda 31 2 | | Interferon Lambda-32 | | IL28B1 2 3 5 | | Interferon Lambda-42 | | Interleukin 28B (Interferon, Lambda 3)1 2 | | Interferon, Lambda 42 | | Cytokine Zcyto222 3 | | Interleukin 28C2 | | IFN-lambda-32 3 | | interleukin-28B2 | | IL-28B2 3 | | interleukin-28C2 | | IL-28C2 3 | | Interleukin-28B3 | | IL28C2 3 | | Interleukin-28C3 | | Interleukin 28B1 | | ZCYTO223 | | IFN-lambda-42 | | |
Export aliases for IFNL3 gene to outside databases |
Summaries
for IFNL3 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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Entrez Gene summary for IFNL3 Gene:
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin
28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster
on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by
viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor
that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). (provided by
RefSeq, Jul 2008)
GeneCards Summary for IFNL3 Gene:
IFNL3 (interferon, lambda 3) is a protein-coding gene. Diseases associated with IFNL3 include hepatitis c virus infection, response to therapy of, and hepatitis b virus infection. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IFNL2.
UniProtKB/Swiss-Prot: IFNL3_HUMAN, Q8IZI9Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent
antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor
composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems
not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in
Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in
the intestinal epithelium
Gene Wiki entry for IFNL3 (Interleukin 28B) Gene
|
Genomic Views
for IFNL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000019.10 NT_011109.17 NC_018930.2
Regulatory elements:
 Search for regulatory transcription factor binding sites for IFNL3
Other transcription factors
Search Chromatin IP Primers for IFNL3
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.13 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.13IFNL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M039735: view genomic region
(about GC identifiers)
Start:
|
39,734,246 bp from pter |
End:
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39,735,646 bp from pter |
Size:
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1,401 bases |
Orientation:
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minus strand |
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Proteins
for IFNL3 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IFNL3_HUMAN, Q8IZI9 (See
protein sequence)Recommended Name: Interferon lambda-3 precursor Size: 196 amino acids; 21706 Da
Sequence caution: Sequence=AAN28264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for IFNL3:3HHC (3D)
Secondary accessions: A2BDE1 Q6VN56 Q7Z4J3 Q8IWL6Explore the universe of human proteins at neXtProt for IFNL3: NX_Q8IZI9
Explore proteomics data for IFNL3 at MOPED
See IFNL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_742151.2
ENSEMBL proteins: ENSP00000409000
IFNL3 Human Recombinant
Protein Products:IFNL3 Antibody
Products:IFNL3 Assay Products: |
Domains /
Families
for IFNL3 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
IFN: Interferons
ProtoNet protein and cluster: Q8IZI9 UniProtKB/Swiss-Prot: IFNL3_HUMAN, Q8IZI9Similarity: Belongs to the lambda interferon family |
Function
for IFNL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Molecular Function:
UniProtKB/Swiss-Prot Summary: IFNL3_HUMAN, Q8IZI9Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent
antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor
composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems
not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in
Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in
the intestinal epitheliumInduction: By viral infections or double-stranded RNA Gene Ontology (GO): 1 molecular function term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- |
IFNL3 for ontologies About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for IFNL3
| | | Predesigned siRNA for gene silencing in human, mouse, rat IFNL3 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for IFNL3 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for IFNL3  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL3 |
Localization
for IFNL3 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot IFNL3_HUMAN, Q8IZI9: SecretedGene Ontology (GO): 1 cellular component term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IEA | -- |
IFNL3 for ontologies About GeneDecksing
|
Pathways & Interactions
for IFNL3 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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SuperPaths for IFNL3 About 
See pathways by source
Pathways by source See SuperPaths
Show all pathways
1  R&D Systems Pathway for IFNL3
1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for IFNL3
1  BioSystems Pathway for IFNL3
2  Kegg Pathways (Kegg details for IFNL3):
IFNL3 for pathways About GeneDecksing
Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IFNL3
Interactions:
Search GeneGlobe Interaction Network for IFNL3
1 Interacting protein for IFNL3 (Q8IZI93) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051607 | defense response to virus |
IEA | -- |
IFNL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFNL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for IFNL3
6 PharmGKB related drug/compound annotations for IFNL3 gene About this table
IFNL3 for compounds About GeneDecksing
|
Transcripts
for IFNL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for IFNL3 gene: NM_172139.2 Unigene Cluster for IFNL3: Interferon, lambda 3 Hs.406744 Unigene Representative Sequence: BC1303141 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000413851(uc010xut.2 uc010xuu.2)
Congresses - knowledge worth sharing: 
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for IFNL3
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat IFNL3 |
Additional mRNA sequence: AY129149.1 AY184374.1 AY336714.1 AY336717.1 BC130314.1 BC130316.1 1 DOTS entry: DT.100018700 6 AceView cDNA sequences: AY336714 NM_172139 AY129149 BV171066 AY184374 AY336717
GeneLoc Exon Structure
|
Expression
for IFNL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
IFNL3 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.406744
Custom PCR Arrays for IFNL3
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for IFNL3
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat IFNL3 | | | Search QuantiTect SYBR Green Assays in human, mouse, rat IFNL3 | | | QuantiFast Probe-based Assays in human, mouse, rat IFNL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL3 |
Orthologs
for IFNL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of chordates.
Orthologs for IFNL3 gene from Selected species (see all 7) About this table
ENSEMBL Gene Tree for IFNL3 (if available)
TreeFam Gene Tree for IFNL3 (if available) |
Paralogs
for IFNL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for IFNL3 gene
- IFNL22 IFNL12
2 SIMAP similar genes for IFNL3 using alignment to 1 protein entry: IFNL3_HUMAN:IFNL2 IFNL1
IFNL3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IFNL3
PGOHUM00000234310
|
Genomic Variants
for IFNL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFNL3 (39734246 - 39735646 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for IFNL3: --
Human Gene Mutation Database (HGMD): IFNL3
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing IFNL3 |
|
Disorders
/ Diseases
for IFNL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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OMIM gene information: 607402
OMIM disorders: 609532
Selected  diseases for IFNL3 (see all 26):
About MalaCardshepatitis c virus infection, response to therapy of hepatitis b virus infection hepatitis c virus tropical spastic paraparesis
spastic paraparesis hepatitis c human t-cell leukemia virus type 1 vaginitis
fatty liver disease viral hepatitis hepatitis b spasticity
bronchiolitis liver disease thalassemia liver cirrhosis
hepatitis t-cell leukemia multiple sclerosis diabetes mellitus
IFNL3 for disorders About GeneDecksing
Congresses - knowledge worth sharing: 
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014Export disorders for IFNL3 gene to outside databases
|
Publications
for IFNL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for IFNL3 gene, integrated from 10 sources (see all 284):
(articles sorted by number of sources associating them with IFNL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti- viral effect of IL-28 and IL-29 on WISH cells. (PubMed id 16539846)1, 2, 9 Li M.C.... He S.H. (Acta Pharmacol. Sin. 2006)
- IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PubMed id 12483210)1, 2, 9 Kotenko S.V.... Donnelly R.P. (Nat. Immunol. 2003)
- IL-28, IL-29 and their class II cytokine receptor IL-28R. (PubMed id 12469119)1, 2, 9 Sheppard P.... Klucher K.M. (Nat. Immunol. 2003)
- Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family. (PubMed id 19457860)1, 2 Gad H.H....Hartmann R. (J. Biol. Chem. 2009)
- Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. (PubMed id 19684573)1, 9 Ge D....Goldstein D.B. (Nature 2009)
- Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. (PubMed id 20389235)1, 9 RallA^n N.I....Soriano V. (AIDS 2010)
- Human interferon-lambda3 is a potent member of the type III interferon family. (PubMed id 18987645)1, 9 Dellgren C....Hartmann R. (Genes Immun. 2009)
- The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. (PubMed id 24241692)1 McFarland A.P....Savan R. (Nat. Immunol. 2014)
- The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection. (PubMed id 23908124)1 Grebely J....Prins M. (Hepatology 2014)
- Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients. (PubMed id 23196939)1 Rallon N.I....Benito J.M. (AIDS 2013)
|
External Searches for IFNL3 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing IFNL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing IFNL3 gene
(According to HUGE)
About This Section
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Specialized Databases showing IFNL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for IFNL3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for IFNL3 gene:
Search GeneIP for patents involving IFNL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFNL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat IFNL3 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing IFNL3 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNL3 | | Predesigned siRNA for gene silencing in human, mouse, rat IFNL3 | | | QuantiFast Probe-based Assays in human, mouse, rat IFNL3 | | Search QuantiTect SYBR Green Assays in human, mouse, rat IFNL3 | | | Custom PCR Arrays for IFNL3 | | Search Chromatin IP Primers for IFNL3 | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IFNL3 | | Search GeneGlobe Interaction Network for IFNL3 | | | Search Regulatory tfbs for IFNL3 |
| |
 |  |  |  | |
| | | Search Tocris compounds for IFNL3 |
| | |  |  |  |
 | | | | |
 |
 |
 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL3 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for IFNL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNL3 |
| | | | LSBio Antibodies in human, mouse, rat for IFNL3 |
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