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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNL3 Gene

protein-coding   GIFtS: 44
GCID: GC19M039735

Interferon, Lambda 3

(Previous names: interleukin 28B, interleukin 28B (interferon, lambda 3))
(Previous symbol: IL28B)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Lambda 31 2     Interferon Lambda-32
IL28B1 2 3 5     Interferon Lambda-42
Interleukin 28B (Interferon, Lambda 3)1 2     Interferon, Lambda 42
Cytokine Zcyto222 3     Interleukin 28C2
IFN-lambda-32 3     interleukin-28B2
IL-28B2 3     interleukin-28C2
IL-28C2 3     Interleukin-28B3
IL28C2 3     Interleukin-28C3
Interleukin 28B1     ZCYTO223
IFN-lambda-42     

External Ids:    HGNC: 183651   Entrez Gene: 2826172   Ensembl: ENSG000001971107   OMIM: 6074025   UniProtKB: Q8IZI93   

Export aliases for IFNL3 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNL3 Gene:
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin
28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster
on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by
viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor
that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). (provided by
RefSeq, Jul 2008)

GeneCards Summary for IFNL3 Gene: 
IFNL3 (interferon, lambda 3) is a protein-coding gene. Diseases associated with IFNL3 include hepatitis c virus infection, response to therapy of, and tropical spastic paraparesis, and among its related super-pathways are NOD-like Receptor Signaling Pathways and STAT3 Pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IFNL2.

UniProtKB/Swiss-Prot: IFNL3_HUMAN, Q8IZI9
Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent
antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor
composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems
not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in
Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in
the intestinal epithelium

Gene Wiki entry for IFNL3 (Interleukin 28B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IFNL3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFNL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.13

IFNL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039735:  view genomic region     (about GC identifiers)

Start:
39,734,246 bp from pter      End:
39,735,646 bp from pter
Size:
1,401 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFNL3_HUMAN, Q8IZI9 (See protein sequence)
Recommended Name: Interferon lambda-3 precursor  
Size: 196 amino acids; 21706 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAN28264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for IFNL3:
3HHC (3D)    
Secondary accessions: A2BDE1 Q6VN56 Q7Z4J3 Q8IWL6

Explore the universe of human proteins at neXtProt for IFNL3: NX_Q8IZI9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZI9

  • IFNL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_742151.2  
    ENSEMBL proteins: 
     ENSP00000409000  

    Human Recombinant Protein Products for IFNL3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals IFNL3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    IFNL3 for ontologies           About GeneDecksing



    IFNL3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFN: Interferons

    ProtoNet protein and cluster: Q8IZI9

    UniProtKB/Swiss-Prot: IFNL3_HUMAN, Q8IZI9
    Similarity: Belongs to the lambda interferon family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFNL3_HUMAN, Q8IZI9
    Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent
    antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor
    composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems
    not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in
    Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in
    the intestinal epithelium
    Induction: By viral infections or double-stranded RNA

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    IFNL3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNL3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNL3 
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    GenScript Custom all cDNA clones Services for IFNL3
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFNL3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    3Type III interferon signaling
    Type III interferon signaling
    4Jak-STAT signaling pathway
    Jak-STAT signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IFNL3
        Toll-Like receptor Signaling Pathways


    1 BioSystems Pathway for IFNL3
        Type III interferon signaling


    2         Kegg Pathways  (Kegg details for IFNL3):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    IFNL3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNL3

    1 Interacting protein for IFNL3 (Q8IZI93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL10RBQ083343I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051607defense response to virus IEA--

    IFNL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IFNL3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFNL3

    6 PharmGKB related drug/compound annotations for IFNL3 gene    About this table
    Drug/compound PharmGKB Annotation
    boceprevir
    interferonsCA  
    peginterferon alfa-2aCA  
    peginterferon alfa-2b  CA  
    ribavirinCA  
    telaprevir

    Search CenterWatch for drugs/clinical trials and news about IFNL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFNL3 gene: 
    NM_172139.2  

    Unigene Cluster for IFNL3:

    Interferon, lambda 3
    Hs.406744
    Unigene Representative Sequence: BC130314
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000413851(uc010xut.2 uc010xuu.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFNL3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFNL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNL3
    Clone
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    GenScript Custom all cDNA clones Services for IFNL3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNL3
    Sirion Biotech Customized lentivirus for stable overexpression of IFNL3 
                         Customized lentivirus expression plasmids for stable overexpression of IFNL3 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNL3

    Additional mRNA sequence: 

    AY129149.1 AY184374.1 AY336714.1 AY336717.1 BC130314.1 BC130316.1 

    1 DOTS entry:

    DT.100018700 

    6 AceView cDNA sequences:

    NM_172139 AY336714 AY129149 AY336717 AY184374 BV171066 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    Genevestigator expression for IFNL3

    SOURCE GeneReport for Unigene cluster: Hs.406744
        SABiosciences Custom PCR Arrays for IFNL3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IFNL3
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFNL3 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifnl35
    Il28a1
    interleukin 28B5
    interleukin 28A1
    76.94(n)1
    68.11(a)1
      7 (16.81 cM)5
    3304961  NM_001024673.21  NP_001019844.21 
     285228365 
    chicken
    (Gallus gallus)
    Aves IL28B1 interleukin 28B (interferon, lambda 3) 55.08(n)
    41.46(a)
      770778  NM_001128496.1  NP_001121968.1 


    ENSEMBL Gene Tree for IFNL3 (if available)
    TreeFam Gene Tree for IFNL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFNL3 gene
    IFNL22  IFNL12  
    3 SIMAP similar genes for IFNL3 using alignment to 1 protein entry:     IFNL3_HUMAN:
    IFNL2    IL28A    IFNL1

    IFNL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IFNL3
    PGOHUM00000234310


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/193 SNPs in IFNL3 are shown (see all 193)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480691511,2
    --39733791(+) ACCCAA/GTACAT 1 -- ds50010--------
    rs711695781,2
    C--39733856(+) TTTAC-/TTTTTT 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs1437217571,2
    --39733895(+) CTGGGA/GTATGT 1 -- ds50010--------
    rs1930496191,2
    --39733907(+) TTACAC/TTCACT 1 -- ds50010--------
    rs1471523331,2
    C--39734020(+) ATGCTA/GCTTTT 1 -- ds50010--------
    rs1403002121,2
    C--39734087(+) CCCACA/GTCATG 1 -- ds50010--------
    rs1129905421,2
    C--39734177(+) TTTACA/GTACAC 1 -- ds50010--------
    rs48032171,2
    C,F,H--39734220(+) TTAAGC/ACAAGT 1 -- ds500120Minor allele frequency- A:0.37NS EA NA WA CSA 2221
    rs1176713041,2
    F--39734226(+) CAAGTG/AGCTAA 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs2001803531,2
    C--39734290(+) TCCCCA/GCTGGC 2 S syn10--------

    HapMap Linkage Disequilibrium report for IFNL3 (39734246 - 39735646 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IFNL3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNL3
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607402   
    OMIM disorders: 609532  
    20/26 diseases for IFNL3 (see all 26):    About MalaCards
    hepatitis c virus infection, response to therapy of    tropical spastic paraparesis    spastic paraparesis    jaundice
    hepatitis b virus infection    viral hepatitis    human t-cell leukemia virus type 1    thalassemia
    hepatitis c    hiv type 1    fatty liver disease    vaginitis
    bronchiolitis    liver cirrhosis    spasticity    t-cell leukemia
    liver disease    multiple sclerosis    diabetes mellitus    alcoholism


    IFNL3 for disorders           About GeneDecksing


    Export disorders for IFNL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFNL3 gene, integrated from 9 sources (see all 248):
    (articles sorted by number of sources associating them with IFNL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. (PubMed id 16539846)1, 2, 9 Li M.C....He S.H. (2006)
    2. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PubMed id 12483210)1, 2, 9 Kotenko S.V.... Donnelly R.P. (2003)
    3. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PubMed id 12469119)1, 2, 9 Sheppard P.... Klucher K.M. (2003)
    4. Interferon-lambda is functionally an interferon but s tructurally related to the interleukin-10 family. (PubMed id 19457860)1, 2 Gad H.H....Hartmann R. (2009)
    5. Genetic variation in IL28B predicts hepatitis C treat ment-induced viral clearance. (PubMed id 19684573)1, 9 Ge D....Goldstein D.B. (2009)
    6. Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. (PubMed id 20389235)1, 9 RallA^n N.I....Soriano V. (2010)
    7. Human interferon-lambda3 is a potent member of the type III interferon family. (PubMed id 18987645)1, 9 Dellgren C....Hartmann R. (2009)
    8. Insulin resistance predicts sustained virological resp onse to treatment of chronic hepatitis C independently of the IL28b rs12979860 p olymorphism. (PubMed id 23121166)1 Del Campo J.A....Romero-Gomez M. (2013)
    9. Polymorphisms near interleukin 28B gene are not associ ated with hepatitis B virus clearance, hepatitis B e antigen clearance and hepat ocellular carcinoma occurrence. (PubMed id 23343781)1 Lee D.H....Kim Y.J. (2013)
    10. Effects of IL28B rs12979860 CC genotype on metabolic p rofile and sustained virologic response in patients with genotype 1 chronic hepa titis C. (PubMed id 23220171)1 Petta S....Bugianesi E. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 282617 HGNC: 18365 AceView: IL28B Ensembl:ENSG00000197110 euGenes: HUgn282617
    ECgene: IFNL3 Kegg: 282617 H-InvDB: IFNL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFNL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFNL3 gene:
    Search GeneIP for patents involving IFNL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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