IFNL3 Gene

Aliases
for IFNL3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Summaries
for IFNL3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for IFNL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9  NT_011109.17  NC_018930.2  

SwitchGear Promoter luciferase reporter plasmid: IFNL3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNL3

IFNL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039735:  view genomic region     (about GC identifiers)

Proteins
for IFNL3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for IFNL3:

3HHC (3D)    

Explore the universe of human proteins at neXtProt for IFNL3: NX_Q8IZI9

Explore proteomics data for IFNL3 at MOPED


See IFNL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

IFNL3 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IFNL3 (IL-28B/IFN-lambda 3)
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for IFNL3 OriGene Custom MassSpec OriGene Custom Protein Services for IFNL3
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	Novus Biologicals IFNL3 Lysate
	Sino Biological Recombinant Protein for IFNL3 Sino Biological Cell Lysate for IFNL3
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for IFNL3
	Search GeneTex for Proteins for IFNL3
	antibodies-online proteins for IFNL3 (13 products)
	antibodies-online peptides for IFNL3

IFNL3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for IFNL3 (IL-28B/IFN-lambda 3, IL-28A/B (IFN-lambda 2/3))
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	Novus Biologicals IFNL3 Antibody
	Search for Antibodies for IFNL3 at Abcam
	Browse Antibodies at Cloud-Clone Corp.
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	antibodies-online antibodies for IFNL3 (35 products)

IFNL3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for IFNL3
	R&D Systems ELISAs for IFNL3 (IL-28B/IFN-lambda 3)
	GenScript Custom Assay Services for IFNL3
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for IFNL3
	antibodies-online kits for IFNL3 (8 products)

Domains /
Families
for IFNL3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8IZI9

Function
for IFNL3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for IFNL3

miRNA Products:		Block miRNA regulation of human, mouse, rat IFNL3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate IFNL3
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for IFNL3
		Predesigned siRNA for gene silencing in human, mouse, rat IFNL3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for IFNL3

Clone Products:		OriGene clones in human, mouse for IFNL3 (see all 5) OriGene ORF clones in mouse, rat for IFNL3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for IFNL3
		Sino Biological Human cDNA Clone for IFNL3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNL3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNL3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IFNL3
		Browse ESI BIO Cell Lines and PureStem Progenitors for IFNL3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL3

Localization
for IFNL3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for IFNL3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for IFNL3 About     See pathways by source

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	SuperPath	Contained pathways About
1	Jak-STAT signaling pathway	Jak-STAT signaling pathway Type III interferon signaling 0.00
2	NOD-like Receptor Signaling Pathways	Toll-Like receptor Signaling Pathways 0.58
3	PEDF Induced Signaling	Cytokine-cytokine receptor interaction 0.43

1 R&D Systems Pathway for IFNL3

Toll-Like receptor Signaling Pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for IFNL3

all-trans-Retinoic Acid Mediated Apoptosis

1 BioSystems Pathway for IFNL3

Type III interferon signaling

2 Kegg Pathways  (Kegg details for IFNL3)

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for IFNL3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for IFNL3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for IFNL3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Orthologs
for IFNL3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for IFNL3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for IFNL3 gene

IFNL2²  IFNL1²  

2 SIMAP similar genes for IFNL3 using alignment to 1 protein entry:     IFNL3_HUMAN:

IFNL2    IFNL1

Find genes that share paralogs with IFNL3           About GenesLikeMe


1 Pseudogenes.org Pseudogene for IFNL3
PGOHUM00000234310

Genomic Variants
for IFNL3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IFNL3 (see all 193)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1480691511,2		--	39733791(+)	ACCCAA/GTACAT	1	--	ds5001		0	--	--	--	--
rs711695781,2	C	--	39733856(+)	TTTAC-/TTTTTT	1	--	ds5001		1		NA	2
rs1437217571,2		--	39733895(+)	CTGGGA/GTATGT	1	--	ds5001		0	--	--	--	--
rs1930496191,2		--	39733907(+)	TTACAC/TTCACT	1	--	ds5001		0	--	--	--	--
rs1471523331,2	C	--	39734020(+)	ATGCTA/GCTTTT	1	--	ds5001		0	--	--	--	--
rs1403002121,2	C	--	39734087(+)	CCCACA/GTCATG	1	--	ds5001		0	--	--	--	--
rs1129905421,2	C	--	39734177(+)	TTTACA/GTACAC	1	--	ds5001		0	--	--	--	--
rs48032171,2	C,F,H	--	39734220(+)	TTAAGC/ACAAGT	1	--	ds5001		20		NS EA NA WA CSA	2221
rs1176713041,2	F	--	39734226(+)	CAAGTG/AGCTAA	1	--	ds5001		1		NA	120
rs2001803531,2	C	--	39734290(+)	TCCCCA/GCTGGC	2	S	syn1		0	--	--	--	--

HapMap Linkage Disequilibrium report for IFNL3 (39734246 - 39735646 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for IFNL3: --
Human Gene Mutation Database (HGMD): IFNL3

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing IFNL3

DNA2.0 Custom Variant and Variant Library Synthesis for IFNL3

Disorders / Diseases
for IFNL3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for IFNL3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti- viral effect of IL-28 and IL-29 on WISH cells. (PubMed id 16539846)^{1, 2, 9} Li M.C.... He S.H. (Acta Pharmacol. Sin. 2006)
2. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PubMed id 12483210)^{1, 2, 9} Kotenko S.V.... Donnelly R.P. (Nat. Immunol. 2003)
3. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PubMed id 12469119)^{1, 2, 9} Sheppard P.... Klucher K.M. (Nat. Immunol. 2003)
4. Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family. (PubMed id 19457860)^{1, 2} Gad H.H....Hartmann R. (J. Biol. Chem. 2009)
5. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. (PubMed id 19684573)^{1, 9} Ge D....Goldstein D.B. (Nature 2009)
6. Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. (PubMed id 20389235)^{1, 9} RallA^n N.I....Soriano V. (AIDS 2010)
7. Human interferon-lambda3 is a potent member of the type III interferon family. (PubMed id 18987645)^{1, 9} Dellgren C....Hartmann R. (Genes Immun. 2009)
8. The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. (PubMed id 24241692)¹ McFarland A.P....Savan R. (Nat. Immunol. 2014)
9. The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection. (PubMed id 23908124)¹ Grebely J....Prins M. (Hepatology 2014)
10. Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients. (PubMed id 23196939)¹ Rallon N.I....Benito J.M. (AIDS 2013)

External Searches for IFNL3 gene

Genome Databases showing IFNL3 gene

Other Databases showing IFNL3 gene

Specialized Databases showing IFNL3 gene

Products
for IFNL3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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