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IFNL3 Gene(Protein Coding)

Interferon Lambda 3

GCID:
GC19M039243
GIFtS:
41
Genes Participants
UDN Logo

Aliases for IFNL3 Gene

Aliases for IFNL3 Gene

  • Interferon Lambda 3 2 3 5
  • Cytokine Zcyto22 3 4
  • Interleukin-28B 3 4
  • Interleukin-28C 3 4
  • IFN-Lambda-3 3 4
  • IL-28B 3 4
  • IL-28C 3 4
  • IL28B 3 4
  • IL28C 3 4
  • Interleukin 28B (Interferon, Lambda 3) 2
  • Interferon, Lambda 4 3
  • Interferon Lambda-3 3
  • Interleukin 28B 2
  • IFN-Lambda-4 3
  • ZCYTO22 4

External Ids for IFNL3 Gene

Previous HGNC Symbols for IFNL3 Gene

  • IL28B

Previous GeneCards Identifiers for IFNL3 Gene

  • GC19M039735

Summaries for IFNL3 Gene

Entrez Gene Summary for IFNL3 Gene

  • This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNL3 Gene

IFNL3 (Interferon Lambda 3) is a Protein Coding gene. Diseases associated with IFNL3 include Hepatitis C Virus and Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding and cytokine activity. An important paralog of this gene is IFNL2.

UniProtKB/Swiss-Prot for IFNL3 Gene

  • Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Gene Wiki entry for IFNL3 Gene

Additional gene information for IFNL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNL3 Gene

Genomics for IFNL3 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IFNL3 Gene

Promoters and enhancers for IFNL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I039892 Enhancer 0.2 Ensembl 5.2 -646.6 -646639 1.9 IFNL3 GC19M039890 FCGBP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFNL3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IFNL3 Gene

Genomic Locations for IFNL3 Gene
chr19:39,243,553-39,247,034
(GRCh38/hg38)
Size:
3,482 bases
Orientation:
Minus strand
chr19:39,734,246-39,735,646
(GRCh37/hg19)

Genomic View for IFNL3 Gene

Genes around IFNL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNL3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IFNL3 Gene

Proteins for IFNL3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IFNL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZI9-IFNL3_HUMAN
    Recommended name:
    Interferon lambda-3
    Protein Accession:
    Q8IZI9
    Secondary Accessions:
    • A2BDE1
    • Q6VN56
    • Q7Z4J3
    • Q8IWL6

    Protein attributes for IFNL3 Gene

    Size:
    196 amino acids
    Molecular mass:
    21706 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN28264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IFNL3 Gene

neXtProt entry for IFNL3 Gene

Post-translational modifications for IFNL3 Gene

No Post-translational modifications

Other Protein References for IFNL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IFNL3 (IL-28B/IFN-lambda 3)
  • R&D Systems Antibodies for IFNL3 (IL-28A/B (IFN-lambda 2/3))

No data available for DME Specific Peptides for IFNL3 Gene

Domains & Families for IFNL3 Gene

Gene Families for IFNL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFNL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZI9

UniProtKB/Swiss-Prot:

IFNL3_HUMAN :
  • Belongs to the lambda interferon family.
Family:
  • Belongs to the lambda interferon family.
genes like me logo Genes that share domains with IFNL3: view

Function for IFNL3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IFNL3 Gene

UniProtKB/Swiss-Prot Function:
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
UniProtKB/Swiss-Prot Induction:
By viral infections or double-stranded RNA.

Phenotypes From GWAS Catalog for IFNL3 Gene

Gene Ontology (GO) - Molecular Function for IFNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IBA --
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with IFNL3: view

Phenotypes for IFNL3 Gene

MGI mutant phenotypes for IFNL3:
inferred from 1 alleles
GenomeRNAi human phenotypes for IFNL3:
genes like me logo Genes that share phenotypes with IFNL3: view

Animal Models for IFNL3 Gene

MGI Knock Outs for IFNL3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IFNL3 Gene

Localization for IFNL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNL3 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for IFNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with IFNL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNL3 Gene

Pathways & Interactions for IFNL3 Gene

genes like me logo Genes that share pathways with IFNL3: view

SIGNOR curated interactions for IFNL3 Gene

Activates:

Gene Ontology (GO) - Biological Process for IFNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007259 JAK-STAT cascade IEA --
GO:0010469 regulation of receptor activity IEA --
GO:0045071 negative regulation of viral genome replication ISS --
GO:0045087 innate immune response IBA --
GO:0050778 positive regulation of immune response IEA --
genes like me logo Genes that share ontologies with IFNL3: view

Drugs & Compounds for IFNL3 Gene

Products:

  1. Drug

(12) Drugs for IFNL3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
boceprevir Approved, Withdrawn Pharma 0
daclatasvir Approved, Investigational Pharma 0
Ledipasvir Approved Pharma 115
Peginterferon alfa-2a Approved, Investigational Pharma 577
Peginterferon alfa-2b Approved Pharma 309

(5) Additional Compounds for IFNL3 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNL3: view

Transcripts for IFNL3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IFNL3 Gene

(3) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNL3 Gene

No ASD Table

Relevant External Links for IFNL3 Gene

GeneLoc Exon Structure for
IFNL3
ECgene alternative splicing isoforms for
IFNL3

Expression for IFNL3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNL3 Gene

mRNA expression in normal human tissues for IFNL3 Gene
mRNA expression by GTEx for IFNL3 Gene

mRNA differential expression in normal tissues according to GTEx for IFNL3 Gene

This gene is overexpressed in Testis (x9.2), Brain - Cerebellum (x5.7), Brain - Cortex (x4.5), Whole Blood (x4.4), and Brain - Cerebellar Hemisphere (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of IFNL3 Gene:

IFNL3

SOURCE GeneReport for Unigene cluster for IFNL3 Gene:

Hs.406744

Evidence on tissue expression from TISSUES for IFNL3 Gene

  • Blood(4.5)
  • Liver(2.6)
genes like me logo Genes that share expression patterns with IFNL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNL3 Gene

Orthologs for IFNL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IL28B 33
  • 98.81 (n)
IFNL3 34
  • 95 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia LOC612543 33
  • 82.71 (n)
-- 34
  • 70 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia LOC100298542 33
  • 81.18 (n)
-- 34
  • 66 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Ifnl2 33 34
  • 76.94 (n)
Ifnl3 16 34
  • 62 (a)
rat
(Rattus norvegicus)
 Mammalia LOC100911249 33
  • 75.29 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 50 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves IL28B 33
  • 53.7 (n)
IFNL 34 34
  • 34 (a)
 ManyToMany
Species where no ortholog for IFNL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNL3 Gene

ENSEMBL:
Gene Tree for IFNL3 (if available)
TreeFam:
Gene Tree for IFNL3 (if available)

Paralogs for IFNL3 Gene

Paralogs for IFNL3 Gene

(2) SIMAP similar genes for IFNL3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFNL3 Gene

genes like me logo Genes that share paralogs with IFNL3: view

Variants for IFNL3 Gene

Sequence variations from dbSNP and Humsavar for IFNL3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs11881222 drug-response, peginterferon alfa-2b response - Efficacy, ribavirin response - Efficacy, peginterferon alfa-2a response - Efficacy 39,244,283(-) A/G intron_variant
rs1000017325 -- 39,243,558(-) G/A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000068148 -- 39,243,281(-) G/A downstream_transcript_variant
rs1001017756 -- 39,244,548(-) C/T intron_variant
rs1003426909 -- 39,246,228(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNL3 Gene

Variant ID Type Subtype PubMed ID
nsv833830 CNV loss 17160897
nsv963046 CNV duplication 23825009

Variation tolerance for IFNL3 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNL3 Gene

Human Gene Mutation Database (HGMD)
IFNL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNL3 Gene

Disorders for IFNL3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for IFNL3 Gene - From: HGMD, OMIM, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, susceptibility to
htlv-1 associated myelopathy/tropical spastic paraparesis
  • tropical spastic paraparesis
tick-borne encephalitis
  • central european encephalitis
drug-induced hepatitis
  • drug-induced chronic hepatitis
med23
  • autosomal recessive nonsyndromic mental retardation-18
- elite association - COSMIC cancer census association via MalaCards
Search IFNL3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNL3

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFNL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNL3 Gene

Publications for IFNL3 Gene

  1. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. (PMID: 16539846) Li MC … He SH (Acta pharmacologica Sinica 2006) 3 4 22 58
  2. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PMID: 12469119) Sheppard P … Klucher KM (Nature immunology 2003) 3 4 22 58
  3. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PMID: 12483210) Kotenko SV … Donnelly RP (Nature immunology 2003) 3 4 22 58
  4. Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. (PMID: 20389235) Rallón NI … Soriano V (AIDS (London, England) 2010) 3 22 58
  5. Human interferon-lambda3 is a potent member of the type III interferon family. (PMID: 18987645) Dellgren C … Hartmann R (Genes and immunity 2009) 3 22 58

Products for IFNL3 Gene

Sources for IFNL3 Gene

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