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IFNL3 Gene

protein-coding   GIFtS: 42
GCID: GC19M039735

Interferon, Lambda 3

(Previous names: interleukin 28B, interleukin 28B (interferon, lambda 3))
(Previous symbol: IL28B)
  See IFNL3-related diseases
at
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Aliases
for IFNL3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Lambda 31 2     Interferon Lambda-32
IL28B1 2 3 5     Interferon Lambda-42
Interleukin 28B (Interferon, Lambda 3)1 2     Interferon, Lambda 42
Cytokine Zcyto222 3     Interleukin 28C2
IFN-lambda-32 3     interleukin-28B2
IL-28B2 3     interleukin-28C2
IL-28C2 3     Interleukin-28B3
IL28C2 3     Interleukin-28C3
Interleukin 28B1     ZCYTO223
IFN-lambda-42     

External Ids:    HGNC: 183651   Entrez Gene: 2826172   Ensembl: ENSG000001971107   OMIM: 6074025   UniProtKB: Q8IZI93   

Export aliases for IFNL3 gene to outside databases


Summaries
for IFNL3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFNL3 Gene:
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin
28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster
on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by
viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor
that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). (provided by
RefSeq, Jul 2008)

GeneCards Summary for IFNL3 Gene:
IFNL3 (interferon, lambda 3) is a protein-coding gene. Diseases associated with IFNL3 include hepatitis c virus infection, response to therapy of, and hepatitic c virus. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IFNL2.

UniProtKB/Swiss-Prot: IFNL3_HUMAN, Q8IZI9
Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent
antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor
composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems
not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in
Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in
the intestinal epithelium

Gene Wiki entry for IFNL3 (Interleukin 28B) Gene


Genomic Views
for IFNL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IFNL3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFNL3 promoter sequence
   Search Chromatin IP Primers for IFNL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.13

IFNL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039735:  view genomic region     (about GC identifiers)

Start:
 39,734,246 bp from pter      End:
 39,735,646 bp from pter
Size:
 1,401 bases      Orientation:
 minus strand

Proteins
for IFNL3 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IFNL3_HUMAN, Q8IZI9 (See protein sequence)
Recommended Name: Interferon lambda-3 precursor  
Size: 196 amino acids; 21706 Da
Sequence caution: Sequence=AAN28264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for IFNL3:
3HHC (3D)    
Secondary accessions: A2BDE1 Q6VN56 Q7Z4J3 Q8IWL6

Explore the universe of human proteins at neXtProt for IFNL3: NX_Q8IZI9

Explore proteomics data for IFNL3 at MOPED


See IFNL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_742151.2  
ENSEMBL proteins: 
 ENSP00000409000  

IFNL3 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IFNL3 (IL-28B/IFN-lambda 3)
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Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for IFNL3
OriGene Custom MassSpec
OriGene Custom Protein Services for IFNL3
GenScript Custom Purified and Recombinant Proteins Services for IFNL3
Novus Biologicals IFNL3 Lysate
Sino Biological Recombinant Protein for IFNL3
Sino Biological Cell Lysate for IFNL3
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 		 Search eBioscience for Proteins for IFNL3 

 		antibodies-online proteins for IFNL3 (13 products) 

 		antibodies-online peptides for IFNL3

IFNL3 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for IFNL3 (IL-28B/IFN-lambda 3, IL-28A/B (IFN-lambda 2/3))
OriGene Antibodies for IFNL3
OriGene Custom Antibody Services for IFNL3
Novus Biologicals IFNL3 Antibody
Search for Antibodies for IFNL3 at Abcam
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for IFNL3
antibodies-online antibodies for IFNL3 (35 products) 

IFNL3 Assay Products:

Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for IFNL3
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Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for IFNL3 
antibodies-online kits for IFNL3 (8 products) 

Domains /
Families
for IFNL3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IFN: Interferons

ProtoNet protein and cluster: Q8IZI9

UniProtKB/Swiss-Prot: IFNL3_HUMAN, Q8IZI9
Similarity: Belongs to the lambda interferon family


Function
for IFNL3 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IFNL3_HUMAN, Q8IZI9
Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent
antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor
composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems
not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in
Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in
the intestinal epithelium
Induction: By viral infections or double-stranded RNA

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
     
Find genes that share ontologies with IFNL3           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for IFNL3

miRNA
Products:    		Block miRNA regulation of human, mouse, rat IFNL3 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate IFNL3
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Inhib. RNA
Products:    		OriGene RNAi products in human, mouse, rat for IFNL3
Predesigned siRNA for gene silencing in human, mouse, rat IFNL3

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for IFNL3

Clone
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OriGene ORF clones in mouse, rat for IFNL3
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Sino Biological Human cDNA Clone for IFNL3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNL3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNL3

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for IFNL3
Browse ESI BIO Cell Lines and PureStem Progenitors for IFNL3 
In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL3


Localization
for IFNL3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IFNL3_HUMAN, Q8IZI9: Secreted

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--

Find genes that share ontologies with IFNL3           About GenesLikeMe


Pathways & Interactions
for IFNL3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IFNL3 About    
See pathways by source

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by		     
SuperPathContained pathways About
1Jak-STAT signaling pathway
Jak-STAT signaling pathway
Type III interferon signaling0.00
2NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways0.58
3PEDF Induced Signaling
Cytokine-cytokine receptor interaction0.43


Find genes that share SuperPaths with IFNL3           About GenesLikeMe

Pathways by source                                   See SuperPaths
Show all pathways

1 R&D Systems Pathway for IFNL3
    Toll-Like receptor Signaling Pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for IFNL3
    all-trans-Retinoic Acid Mediated Apoptosis

1 BioSystems Pathway for IFNL3
    Type III interferon signaling



2 Kegg Pathways  (Kegg details for IFNL3):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IFNL3
Interactions:

    Search GeneGlobe Interaction Network for IFNL3

1 Interacting protein for IFNL3 (Q8IZI93) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IL10RBQ083343I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0051607defense response to virus IEA--

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Drugs & Compounds
for IFNL3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IFNL3

8 PharmGKB related drug/compound annotations for IFNL3 gene    About this table
Drug/compound PharmGKB Annotation
boceprevir
interferonsCA  
peginterferon alfa-2a  CA  
peginterferon alfa-2b  CA  
ribavirin  CA  
simeprevir
sofosbuvir
telaprevir  CA  



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Transcripts
for IFNL3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IFNL3 gene: 
NM_172139.2  

Unigene Cluster for IFNL3:

Interferon, lambda 3
Hs.406744
Unigene Representative Sequence: BC130314
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000413851(uc010xut.2 uc010xuu.2)
miRNA
Products:     		 Block miRNA regulation of human, mouse, rat IFNL3 using miScript Target Protectors
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		OriGene RNAi products in human, mouse, rat for IFNL3
Predesigned siRNA for gene silencing in human, mouse, rat IFNL3
Clone
Products:     		 OriGene clones in human, mouse for IFNL3 (see all 5)
OriGene ORF clones in mouse, rat for IFNL3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNL3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNL3
Primer
Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for IFNL3
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IFNL3
  Search QuantiTect SYBR Green Assays in human, mouse, rat IFNL3
  QuantiFast Probe-based Assays in human, mouse, rat IFNL3

Additional mRNA sequence: 

AY129149.1 AY184374.1 AY336714.1 AY336717.1 BC130314.1 BC130316.1 

1 DOTS entry:

DT.100018700 

6 AceView cDNA sequences:

AY336714 NM_172139 AY129149 BV171066 AY184374 AY336717 

GeneLoc Exon Structure


Expression
for IFNL3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CGAP TAG: --

IFNL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

IFNL3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.406744
    Custom PCR Arrays for IFNL3
Primer
Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IFNL3
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IFNL3
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QuantiFast Probe-based Assays in human, mouse, rat IFNL3
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL3

Orthologs
for IFNL3 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IFNL3 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Ifnl35
Ifnl21		 interleukin 28B5
interferon lambda 21		 76.94(n)1
68.11(a)1		   7 (16.81 cM)5
3304961  NM_001024673.21  NP_001019844.21 
 285228365 
chicken
(Gallus gallus)		 Aves IL28B1 interleukin 28B (interferon, lambda 3) 53.7(n)
40(a)		   770778  NM_001128496.1  NP_001121968.1 


ENSEMBL Gene Tree for IFNL3 (if available)
TreeFam Gene Tree for IFNL3 (if available)

Paralogs
for IFNL3 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IFNL3 gene
IFNL22  IFNL12  
2 SIMAP similar genes for IFNL3 using alignment to 1 protein entry:     IFNL3_HUMAN:
IFNL2    IFNL1

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1 Pseudogenes.org Pseudogene for IFNL3
PGOHUM00000234310


Genomic Variants
for IFNL3 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IFNL3 (see all 193)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 19 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1480691511,2
--39733791(+) ACCCAA/GTACAT 1 -- ds50010--------
rs711695781,2
C--39733856(+) TTTAC-/TTTTTT 1 -- ds50011Minor allele frequency- T:0.00NA 2
rs1437217571,2
--39733895(+) CTGGGA/GTATGT 1 -- ds50010--------
rs1930496191,2
--39733907(+) TTACAC/TTCACT 1 -- ds50010--------
rs1471523331,2
C--39734020(+) ATGCTA/GCTTTT 1 -- ds50010--------
rs1403002121,2
C--39734087(+) CCCACA/GTCATG 1 -- ds50010--------
rs1129905421,2
C--39734177(+) TTTACA/GTACAC 1 -- ds50010--------
rs48032171,2
C,F,H--39734220(+) TTAAGC/ACAAGT 1 -- ds500120Minor allele frequency- A:0.37NS EA NA WA CSA 2221
rs1176713041,2
F--39734226(+) CAAGTG/AGCTAA 1 -- ds50011Minor allele frequency- A:0.01NA 120
rs2001803531,2
C--39734290(+) TCCCCA/GCTGGC 2 S syn10--------

HapMap Linkage Disequilibrium report for IFNL3 (39734246 - 39735646 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for IFNL3: --
Human Gene Mutation Database (HGMD): IFNL3
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IFNL3
DNA2.0 Custom Variant and Variant Library Synthesis for IFNL3

Disorders / Diseases
for IFNL3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TryGeneCards Plus		 OMIM gene information: 607402   
OMIM disorders: 609532  
5 diseases for IFNL3:    
About MalaCards
hepatitis c virus infection, response to therapy of    hepatitic c virus    hepatitis b virus infection    hepatitis c virus
hepatitis c


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Export disorders for IFNL3 gene to outside databases

Publications
for IFNL3 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IFNL3 gene, integrated from 10 sources (see all 284):
(articles sorted by number of sources associating them with IFNL3)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti- viral effect of IL-28 and IL-29 on WISH cells. (PubMed id 16539846)1, 2, 9 Li M.C.... He S.H. (Acta Pharmacol. Sin. 2006)
  2. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PubMed id 12483210)1, 2, 9 Kotenko S.V.... Donnelly R.P. (Nat. Immunol. 2003)
  3. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PubMed id 12469119)1, 2, 9 Sheppard P.... Klucher K.M. (Nat. Immunol. 2003)
  4. Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family. (PubMed id 19457860)1, 2 Gad H.H....Hartmann R. (J. Biol. Chem. 2009)
  5. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. (PubMed id 19684573)1, 9 Ge D....Goldstein D.B. (Nature 2009)
  6. Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. (PubMed id 20389235)1, 9 RallA^n N.I....Soriano V. (AIDS 2010)
  7. Human interferon-lambda3 is a potent member of the type III interferon family. (PubMed id 18987645)1, 9 Dellgren C....Hartmann R. (Genes Immun. 2009)
  8. The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. (PubMed id 24241692)1 McFarland A.P....Savan R. (Nat. Immunol. 2014)
  9. The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection. (PubMed id 23908124)1 Grebely J....Prins M. (Hepatology 2014)
  10. Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients. (PubMed id 23196939)1 Rallon N.I....Benito J.M. (AIDS 2013)

External Searches for IFNL3 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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PubMed
OMIM
NCBI Bookshelf
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Genome Databases showing IFNL3 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 282617 HGNC: 18365 AceView: IL28B Ensembl:ENSG00000197110 euGenes: HUgn282617
ECgene: IFNL3 Kegg: 282617 H-InvDB: IFNL3

Other Databases showing IFNL3 gene

(According to HUGE)
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Specialized Databases showing IFNL3 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IFNL3 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for IFNL3 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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TryGeneCards Plus		Patent Information for IFNL3 gene:
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Products
for IFNL3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 EMD Millipore genomic analysis products

  
 Antibodies for IFNL3 (IL-28B/IFN-lambda 3)   Browse Cell Culture Products  
 ELISAs for IFNL3 (IL-28B/IFN-lambda 3)   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
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 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Recombinant/Natural Proteins for IFNL3 (IL-28B/IFN-lambda 3)   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for IFNL3   OriGene RNAi products in human, mouse, rat for IFNL3  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IFNL3  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for IFNL3  
 OriGene qSTAR qPCR primer pairs in human, mouse for IFNL3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for IFNL3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for IFNL3   OriGene Custom Protein Services for IFNL3  

 		 
 Block miRNA regulation of human, mouse, rat IFNL3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IFNL3
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNL3 Predesigned siRNA for gene silencing in human, mouse, rat IFNL3
 QuantiFast Probe-based Assays in human, mouse, rat IFNL3 Search QuantiTect SYBR Green Assays in human, mouse, rat IFNL3
 Custom PCR Arrays for IFNL3 Search Chromatin IP Primers for IFNL3
 Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IFNL3 Search GeneGlobe Interaction Network for IFNL3
 Search Regulatory tfbs for IFNL3
 GenScript Custom Purified and Recombinant Proteins Services for IFNL3 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for IFNL3
 GenScript Custom Assay Services for IFNL3 GenScript Custom overexpressing Cell Line Services for IFNL3
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for IFNL3
 Proteins for IFNL3
 Cell Lysates for IFNL3
 cDNA Clones for IFNL3
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 IFNL3 antibodies
 IFNL3 lysates
 Search for Antibodies for IFNL3 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for IFNL3
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for IFNL3
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL3
 Browse SwitchGear 3'UTR luciferase reporter plasmids for IFNL3
 SwitchGear Promoter luciferase reporter plasmids for IFNL3
 Search ThermoFisher Antibodies for IFNL3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNL3
 Browse compounds at ApexBio
 Search Addgene for plasmids for IFNL3
  Search eBioscience for proteins for IFNL3
  Search eBioscience for elisas for IFNL3
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for IFNL3
 antibodies-online antibodies for IFNL3 (35 products)
 antibodies-online kits for IFNL3 (8 products)
 antibodies-online peptides for IFNL3
 antibodies-online proteins for IFNL3 (13 products)
       
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