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Aliases for IFNL3 Gene

Aliases for IFNL3 Gene

  • Interferon, Lambda 3 2 3
  • IL28B 3 4 6
  • Interleukin 28B (Interferon, Lambda 3) 2 3
  • Cytokine Zcyto22 3 4
  • Interleukin-28B 3 4
  • Interleukin-28C 3 4
  • IFN-Lambda-3 3 4
  • IL-28B 3 4
  • IL-28C 3 4
  • IL28C 3 4
  • Interferon, Lambda 4 3
  • Interferon Lambda-3 3
  • Interferon Lambda-4 3
  • Interleukin 28B 2
  • Interleukin 28C 3
  • IFN-Lambda-4 3
  • ZCYTO22 4

External Ids for IFNL3 Gene

Previous Symbols for IFNL3 Gene

  • IL28B

Summaries for IFNL3 Gene

Entrez Gene Summary for IFNL3 Gene

  • This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNL3 Gene

IFNL3 (Interferon, Lambda 3) is a Protein Coding gene. Diseases associated with IFNL3 include hepatitis c virus and response to antiviral treatment in hepatitis c. Among its related pathways are NOD-like Receptor Signaling Pathways and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IFNL2.

UniProtKB/Swiss-Prot for IFNL3 Gene

  • Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Gene Wiki entry for IFNL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNL3 Gene

Genomics for IFNL3 Gene

Genomic Location for IFNL3 Gene

Start:
39,243,553 bp from pter
End:
39,245,129 bp from pter
Size:
1,577 bases
Orientation:
Minus strand

Genomic View for IFNL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNL3 Gene

No data available for Regulatory Elements for IFNL3 Gene

Proteins for IFNL3 Gene

  • Protein details for IFNL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZI9-IFNL3_HUMAN
    Recommended name:
    Interferon lambda-3
    Protein Accession:
    Q8IZI9
    Secondary Accessions:
    • A2BDE1
    • Q6VN56
    • Q7Z4J3
    • Q8IWL6

    Protein attributes for IFNL3 Gene

    Size:
    196 amino acids
    Molecular mass:
    21706 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN28264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IFNL3 Gene

neXtProt entry for IFNL3 Gene

Proteomics data for IFNL3 Gene at MOPED

Post-translational modifications for IFNL3 Gene

No Post-translational modifications

Other Protein References for IFNL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNL3 Gene

Domains for IFNL3 Gene

Gene Families for IFNL3 Gene

HGNC:
  • IFN :Interferons

Protein Domains for IFNL3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IZI9

UniProtKB/Swiss-Prot:

IFNL3_HUMAN
Family:
  • Belongs to the lambda interferon family.:
    • Q8IZI9
genes like me logo Genes that share domains with IFNL3: view

No data available for Suggested Antigen Peptide Sequences for IFNL3 Gene

Function for IFNL3 Gene

Molecular function for IFNL3 Gene

UniProtKB/Swiss-Prot Function: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
UniProtKB/Swiss-Prot Induction: By viral infections or double-stranded RNA.

Gene Ontology (GO) - Molecular Function for IFNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IBA --
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with IFNL3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNL3 Gene

Localization for IFNL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNL3 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for IFNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNL3: view

No data available for Subcellular locations from COMPARTMENTS for IFNL3 Gene

Pathways for IFNL3 Gene

genes like me logo Genes that share pathways with IFNL3: view

Pathways by source for IFNL3 Gene

1 R&D Systems pathway for IFNL3 Gene
1 Qiagen pathway for IFNL3 Gene
1 BioSystems pathway for IFNL3 Gene

Gene Ontology (GO) - Biological Process for IFNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007259 JAK-STAT cascade IEA --
GO:0045071 negative regulation of viral genome replication ISS --
GO:0045087 innate immune response IBA --
GO:0050778 positive regulation of immune response IEA --
GO:0050863 regulation of T cell activation IBA --
genes like me logo Genes that share ontologies with IFNL3: view

Compounds for IFNL3 Gene

(8) PharmGKB related drug/compound annotations for IFNL3 Gene

genes like me logo Genes that share compounds with IFNL3: view

Transcripts for IFNL3 Gene

mRNA/cDNA for IFNL3 Gene

(3) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNL3 Gene

No ASD Table

Relevant External Links for IFNL3 Gene

GeneLoc Exon Structure for
IFNL3
ECgene alternative splicing isoforms for
IFNL3

Expression for IFNL3 Gene

mRNA expression in normal human tissues for IFNL3 Gene

mRNA differential expression in normal tissues according to GTEx for IFNL3 Gene

This gene is overexpressed in Testis (9.2), Brain - Cerebellum (5.7), Brain - Cortex (4.5), Whole Blood (4.4), and Brain - Cerebellar Hemisphere (4.0).

SOURCE GeneReport for Unigene cluster for IFNL3 Gene Hs.406744

genes like me logo Genes that share expressions with IFNL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for IFNL3 Gene

Orthologs for IFNL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNL3 36
  • 95 (a)
OneToOne
IL28B 35
  • 98.81 (n)
  • 96.43 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
OneToMany
LOC100298542 35
  • 81.18 (n)
  • 69.89 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
OneToMany
LOC612543 35
  • 82.71 (n)
  • 75.4 (a)
mouse
(Mus musculus)
Mammalia Ifnl2 35
  • 76.94 (n)
  • 68.11 (a)
Ifnl2 36
  • 65 (a)
ManyToMany
Ifnl3 16
Ifnl3 36
  • 62 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100911249 35
  • 75.29 (n)
  • 65.52 (a)
chicken
(Gallus gallus)
Aves IFNL 36
  • 34 (a)
ManyToMany
IFNL 36
  • 34 (a)
ManyToMany
IL28B 35
  • 53.7 (n)
  • 40 (a)
Species with no ortholog for IFNL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNL3 Gene

ENSEMBL:
Gene Tree for IFNL3 (if available)
TreeFam:
Gene Tree for IFNL3 (if available)

Paralogs for IFNL3 Gene

Paralogs for IFNL3 Gene

Selected SIMAP similar genes for IFNL3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFNL3 Gene

genes like me logo Genes that share paralogs with IFNL3: view

Variants for IFNL3 Gene

Sequence variations from dbSNP and Humsavar for IFNL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs628973 -- 39,244,626(-) TCCTG(A/T)AGAAG intron-variant
rs629008 -- 39,244,650(+) TCCCT(A/G)CAGTA intron-variant
rs629976 - 39,244,885(-) GCTCC(A/G)CGGGG missense, reference
rs630388 -- 39,244,962(+) TCCCC(A/G)GTCAT reference, synonymous-codon
rs4803217 -- 39,243,580(+) TTAAG(A/C)CAAGT downstream-variant-500B

Relevant External Links for IFNL3 Gene

HapMap Linkage Disequilibrium report
IFNL3
Human Gene Mutation Database (HGMD)
IFNL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IFNL3 Gene

Disorders for IFNL3 Gene

(1) OMIM Diseases for IFNL3 Gene (607402)

genes like me logo Genes that share disorders with IFNL3: view

No data available for UniProtKB/Swiss-Prot for IFNL3 Gene

Publications for IFNL3 Gene

  1. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PMID: 12469119) Sheppard P. … Klucher K.M. (Nat. Immunol. 2003) 3 4 23
  2. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PMID: 12483210) Kotenko S.V. … Donnelly R.P. (Nat. Immunol. 2003) 3 4 23
  3. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti- viral effect of IL-28 and IL-29 on WISH cells. (PMID: 16539846) Li M.C. … He S.H. (Acta Pharmacol. Sin. 2006) 3 4 23
  4. Human interferon-lambda3 is a potent member of the type III interferon family. (PMID: 18987645) Dellgren C. … Hartmann R. (Genes Immun. 2009) 3 23
  5. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. (PMID: 19684573) Ge D. … Goldstein D.B. (Nature 2009) 3 23

Products for IFNL3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNL3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFNL3
    • Block miRNA regulation of IFNL3 using miScript Target Protectors

    Sources for IFNL3 Gene

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