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IFNL2 Gene

protein-coding   GIFtS: 44
GCID: GC19P039760

Interferon, Lambda 2

(Previous names: interleukin 28A, interleukin 28A (interferon, lambda 2))
(Previous symbol: IL28A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Lambda 21 2     Interferon Lambda 22
IL28A1 2 3 5     Interferon Lambda-22
Interleukin 28A (Interferon, Lambda 2)1 2     Interferon-Lambda 22
Cytokine Zcyto202 3     interleukin-28A2
IFN-lambda-22 3     Interleukin-28A3
IL-28A2 3     ZCYTO203
Interleukin 28A1     

External Ids:    HGNC: 183641   Entrez Gene: 2826162   Ensembl: ENSG000001837097   OMIM: 6074015   UniProtKB: Q8IZJ03   

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(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFNL2 Gene:
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin
28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster
on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by
viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor
that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). (provided by
RefSeq, Jul 2008)

GeneCards Summary for IFNL2 Gene:
IFNL2 (interferon, lambda 2) is a protein-coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IFNL3.

UniProtKB/Swiss-Prot: IFNL2_HUMAN, Q8IZJ0
Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent
antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor
composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems
not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in
Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in
the intestinal epithelium




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IFNL2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNL2 promoter sequence
   Search Chromatin IP Primers for IFNL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.13

IFNL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNL2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039760:  view genomic region     (about GC identifiers)

Start:
39,759,154 bp from pter      End:
39,760,732 bp from pter
Size:
1,579 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IFNL2_HUMAN, Q8IZJ0 (See protein sequence)
Recommended Name: Interferon lambda-2 precursor  
Size: 200 amino acids; 22288 Da
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Sequence caution: Sequence=AAR24510.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q45KQ8 Q6VN55 Q8IWL7

Explore the universe of human proteins at neXtProt for IFNL2: NX_Q8IZJ0

Explore proteomics data for IFNL2 at MOPED


See IFNL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_742150.1  
ENSEMBL proteins: 
 ENSP00000333639  

IFNL2 Human Recombinant Protein Products:

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eBioscience Proteins for IFNL2: (see all 2
                    Human IL-28A (IFN lambda 2) Recombinant Protein Carrier-Free 100 ug

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IFN: Interferons

ProtoNet protein and cluster: Q8IZJ0

UniProtKB/Swiss-Prot: IFNL2_HUMAN, Q8IZJ0
Similarity: Belongs to the lambda interferon family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IFNL2_HUMAN, Q8IZJ0
Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent
antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor
composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems
not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in
Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in
the intestinal epithelium
Induction: By viral infections or double-stranded RNA

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
     
Find genes that share ontologies with IFNL2           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for IFNL2:
 Decreased viability 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IFNL2_HUMAN, Q8IZJ0: Secreted

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--

Find genes that share ontologies with IFNL2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IFNL2 About    
See pathways by source

SuperPathContained pathways About
1Jak-STAT signaling pathway
Jak-STAT signaling pathway
Type III interferon signaling0.00
2NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways0.58
3PEDF Induced Signaling
Cytokine-cytokine receptor interaction0.43


Find genes that share SuperPaths with IFNL2           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for IFNL2
    Toll-Like receptor Signaling Pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for IFNL2
    all-trans-Retinoic Acid Mediated Apoptosis

1 BioSystems Pathway for IFNL2
    Type III interferon signaling



2 Kegg Pathways  (Kegg details for IFNL2):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IFNL2
Interactions:

    Search GeneGlobe Interaction Network for IFNL2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for IFNL2 (Q8IZJ03 ENSP000003336394) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IL10RBQ083343, ENSP000002902004I2D: score=1 STRING: ENSP00000290200
IFNLR1Q8IU573, ENSP000003278244I2D: score=1 STRING: ENSP00000327824
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0051607defense response to virus IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IFNL2

2 Novoseek inferred chemical compound relationships for IFNL2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
2',5'-oligoadenylate 72.5 1 18657576 (1)
poly(i-c) 67 1 17176437 (1)



Find genes that share compounds with IFNL2           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IFNL2 gene: 
NM_172138.1  

Unigene Cluster for IFNL2:

Interferon, lambda 2
Hs.567792
Unigene Representative Sequence: DQ126337
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000331982(uc002oku.1)
miRNA
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Products:
     
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat IFNL2

Additional mRNA sequence: 

AY129148.1 AY184373.1 AY336715.1 BC113581.1 BC113583.1 DQ126337.1 

1 DOTS entry:

DT.121488303 

7 AceView cDNA sequences:

AY129148 AY336715 NM_172138 AA774195 BV177961 BV177834 AY184373 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

IFNL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IFNL2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.567792
    Custom PCR Arrays for IFNL2
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IFNL2 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ifnl25 interleukin 28A   --   7 (16.80 cM) 28508861 
chicken
(Gallus gallus)
Aves IFNL6
IFNL6
Gallus gallus interleukin 28B (interferon, lambda ...
Gallus gallus interleukin 28B (interferon, lambda ...
33(a)
33(a)
many ↔ many
many ↔ many
AADN03016676.1(2617-4124)
AADN03020056.1(8264-9772)


ENSEMBL Gene Tree for IFNL2 (if available)
TreeFam Gene Tree for IFNL2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IFNL2 gene
IFNL32  IFNL12  
2 SIMAP similar genes for IFNL2 using alignment to 1 protein entry:     IFNL2_HUMAN:
IFNL3    IFNL1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IFNL2 (see all 139)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs3749657281,2
C--39757289(+) CTCCAA/GCTGAG 1 -- us2k10--------
rs612605631,2
C--39757560(+) TCCTTC/TGTCAC 1 -- us2k10--------
rs1930062201,2
--39757561(+) CCTTCC/GTCACA 1 -- us2k10--------
rs6648931,2
C,F,H--39757572(-) AAGAAT/CTGAGG 1 -- us2k112Minor allele frequency- C:0.08NS EA NA 1730
rs1837491661,2
--39757758(+) ACTAAA/GAATAC 1 -- us2k10--------
rs1884234411,2
--39757873(+) AGATGG/TTGCCT 1 -- us2k10--------
rs25968071,2
C,F--39757926(-) gtgagT/CgagCA 1 -- us2k17Minor allele frequency- C:0.44NA WA CSA 247
rs1131962761,2
F--39758000(+) ATATAC/TACACA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
rs1511753351,2
--39758006(+) ACACAC/TACATA 1 -- us2k10--------
rs755574401,2
C--39758153(+) AAAATA/TAGTTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for IFNL2 (39759154 - 39760732 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for IFNL2: --
Human Gene Mutation Database (HGMD): IFNL2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IFNL2
DNA2.0 Custom Variant and Variant Library Synthesis for IFNL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607401    OMIM disorders: --


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1 Novoseek inferred disease relationship for IFNL2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 0 1 16618774 (1)


Export disorders for IFNL2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IFNL2 gene, integrated from 10 sources (see all 43):
(articles sorted by number of sources associating them with IFNL2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti- viral effect of IL-28 and IL-29 on WISH cells. (PubMed id 16539846)1, 2, 9 Li M.C.... He S.H. (Acta Pharmacol. Sin. 2006)
  2. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PubMed id 12469119)1, 2, 9 Sheppard P.... Klucher K.M. (Nat. Immunol. 2003)
  3. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PubMed id 12483210)1, 2, 9 Kotenko S.V.... Donnelly R.P. (Nat. Immunol. 2003)
  4. Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. (PubMed id 16146571)1, 2 Zhu H.... Liu C. (Virol. J. 2005)
  5. IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. (PubMed id 16051921)1, 9 Brand S....Dambacher J. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005)
  6. Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma. (PubMed id 16618774)1, 9 Lasfar A....Kotenko S.V. (Cancer Res. 2006)
  7. Biological activity of interleukins-28 and -29: comparison with type I interferons. (PubMed id 15899585)1, 9 Meager A....Wadhwa M. (Cytokine 2005)
  8. Gene polymorphisms of interleukin-28, p21-activated protein kinases 4, and response to interferon-I+ based therapy in Chinese patients with chronic hepatitis B. (PubMed id 23652058)1 Yu F.X....Liu D.W. (Chin. Med. J. 2013)
  9. Interferon-I>s: special immunomodulatory agents and potential therapeutic targets. (PubMed id 23207147)1 Zheng Y.W....Ren X.B. (J Innate Immun 2013)
  10. Sequence analysis of the IL28A/IL28B inverted gene duplication that contains polymorphisms associated with treatment response in hepatitis C patients. (PubMed id 22253847)1 Reynolds J.M....Johnston G.I. (PLoS ONE 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 282616 HGNC: 18364 AceView: IL28A Ensembl:ENSG00000183709 euGenes: HUgn282616
ECgene: IFNL2 Kegg: 282616 H-InvDB: IFNL2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IFNL2 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Interleukin_28

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IFNL2 gene:
Search GeneIP for patents involving IFNL2

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
 Antibodies for IFNL2 (IL-28A/IFN-lambda 2)   Browse Cell Culture Products  
 ELISAs for IFNL2 (IL-28A/IFN-lambda 2)   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for IFNL2 (IL-28A/IFN-lambda 2)  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Recombinant/Natural Proteins for IFNL2 (IL-28A/IFN-lambda 2)   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IFNL2  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IFNL2  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for IFNL2  
 OriGene qSTAR qPCR primer pairs in human, mouse for IFNL2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for IFNL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for IFNL2   OriGene Custom Protein Services for IFNL2  

 
 
 Block miRNA regulation of human, mouse, rat IFNL2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IFNL2
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNL2 Predesigned siRNA for gene silencing in human, mouse, rat IFNL2
 QuantiFast Probe-based Assays in human, mouse, rat IFNL2 QuantiTect SYBR Green Assays in human, mouse, rat IFNL2
 Custom PCR Arrays for IFNL2 Search Chromatin IP Primers for IFNL2
 Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IFNL2 Search GeneGlobe Interaction Network for IFNL2
 Search Regulatory tfbs for IFNL2
 GenScript Custom Purified and Recombinant Proteins Services for IFNL2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for IFNL2
 GenScript Custom Assay Services for IFNL2 GenScript Custom overexpressing Cell Line Services for IFNL2
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for IFNL2
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for IFNL2
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 IFNL2 antibodies
 IFNL2 proteins
 IFNL2 lysates
 Search for Antibodies for IFNL2 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for IFNL2
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for IFNL2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL2
 Browse SwitchGear 3'UTR luciferase reporter plasmids for IFNL2
 SwitchGear Promoter luciferase reporter plasmids for IFNL2
 ThermoFisher Antibodies for IFNL2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNL2
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFNL2
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFNL2
 LSBio Antibodies in human, mouse, rat for IFNL2
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for IFNL2
 eBioscience proteins for IFNL2 (Human IL-28A (IFN lambda 2) Recombinant Protein Carrier-Free 100 ug)
  Search eBioscience for elisas for IFNL2
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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