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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNL2 Gene

protein-coding   GIFtS: 47
GCID: GC19P039760

Interferon, Lambda 2

(Previous names: interleukin 28A, interleukin 28A (interferon, lambda 2))
(Previous symbol: IL28A)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Lambda 21 2     Interferon Lambda 22
IL28A1 2 3 5     Interferon Lambda-22
Interleukin 28A (Interferon, Lambda 2)1 2     Interferon-Lambda 22
Cytokine Zcyto202 3     interleukin-28A2
IFN-lambda-22 3     Interleukin-28A3
IL-28A2 3     ZCYTO203
Interleukin 28A1     

External Ids:    HGNC: 183641   Entrez Gene: 2826162   Ensembl: ENSG000001837097   OMIM: 6074015   UniProtKB: Q8IZJ03   

Export aliases for IFNL2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNL2 Gene:
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin
28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster
on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by
viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor
that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). (provided by
RefSeq, Jul 2008)

GeneCards Summary for IFNL2 Gene: 
IFNL2 (interferon, lambda 2) is a protein-coding gene. Diseases associated with IFNL2 include vaginitis, and influenza, and among its related super-pathways are NOD-like Receptor Signaling Pathways and STAT3 Pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IFNL3.

UniProtKB/Swiss-Prot: IFNL2_HUMAN, Q8IZJ0
Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent
antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor
composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems
not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in
Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in
the intestinal epithelium




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IFNL2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFNL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.13

IFNL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNL2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039760:  view genomic region     (about GC identifiers)

Start:
39,759,154 bp from pter      End:
39,760,732 bp from pter
Size:
1,579 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFNL2_HUMAN, Q8IZJ0 (See protein sequence)
Recommended Name: Interferon lambda-2 precursor  
Size: 200 amino acids; 22288 Da
Subcellular location: Secreted
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Sequence caution: Sequence=AAR24510.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6VN55 Q8IWL7

Explore the universe of human proteins at neXtProt for IFNL2: NX_Q8IZJ0

Explore proteomics data for IFNL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZJ0

  • IFNL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFNL2 Protein Expression
    REFSEQ proteins: NP_742150.1  
    ENSEMBL proteins: 
     ENSP00000333639  

    Human Recombinant Protein Products for IFNL2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IFNL2 (IL-28A/IFN-lambda 2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IFNL2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IFNL2
    GenScript Custom Purified and Recombinant Proteins Services for IFNL2
    Novus Biologicals IFNL2 Proteins
    Novus Biologicals IFNL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    IFNL2 for ontologies           About GeneDecksing



    IFNL2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for IFNL2
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    LSBio Antibodies in human, mouse, rat for IFNL2 

    Assay Products for IFNL2: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for IFNL2 (IL-28A/IFN-lambda 2)         (see all)
    GenScript Custom Assay Services for IFNL2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFN: Interferons

    ProtoNet protein and cluster: Q8IZJ0

    UniProtKB/Swiss-Prot: IFNL2_HUMAN, Q8IZJ0
    Similarity: Belongs to the lambda interferon family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFNL2_HUMAN, Q8IZJ0
    Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent
    antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor
    composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems
    not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in
    Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in
    the intestinal epithelium
    Induction: By viral infections or double-stranded RNA

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    IFNL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IFNL2:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNL2 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFNL2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of IFNL2

    Clone
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    OriGene ORF clones in mouse, rat for IFNL2
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    GenScript Custom all cDNA clones Services for IFNL2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNL2
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                         Customized lentivirus expression plasmids for stable overexpression of IFNL2 

    Cell Line
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    Search LifeMap BioReagents cell lines for IFNL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFNL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    3Type III interferon signaling
    Type III interferon signaling
    4Jak-STAT signaling pathway
    Jak-STAT signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IFNL2
        Toll-Like receptor Signaling Pathways


    1 BioSystems Pathway for IFNL2
        Type III interferon signaling


    2         Kegg Pathways  (Kegg details for IFNL2):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    IFNL2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNL2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for IFNL2 (Q8IZJ03 ENSP000003336394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL10RBQ083343, ENSP000002902004I2D: score=1 STRING: ENSP00000290200
    IFNLR1Q8IU573, ENSP000003278244I2D: score=1 STRING: ENSP00000327824
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051607defense response to virus IEA--

    IFNL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IFNL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFNL2

    2 Novoseek inferred chemical compound relationships for IFNL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 72.5 1 18657576 (1)
    poly(i-c) 67 1 17176437 (1)

    Search CenterWatch for drugs/clinical trials and news about IFNL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFNL2 gene: 
    NM_172138.1  

    Unigene Cluster for IFNL2:

    Interferon, lambda 2
    Hs.567792
    Unigene Representative Sequence: DQ126337
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331982(uc002oku.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNL2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFNL2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFNL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNL2
    Clone
    Products:
         
    OriGene clones in human, mouse for IFNL2 (see all 6)
    OriGene ORF clones in mouse, rat for IFNL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IFNL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNL2
    Sirion Biotech Customized lentivirus for stable overexpression of IFNL2 
                         Customized lentivirus expression plasmids for stable overexpression of IFNL2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNL2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNL2

    Additional mRNA sequence: 

    AY129148.1 AY184373.1 AY336715.1 BC113581.1 BC113583.1 DQ126337.1 

    1 DOTS entry:

    DT.121488303 

    7 AceView cDNA sequences:

    AY129148 NM_172138 AY336715 AY184373 BV177834 AA774195 BV177961 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See IFNL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFNL2

    SOURCE GeneReport for Unigene cluster: Hs.567792
        SABiosciences Custom PCR Arrays for IFNL2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFNL2 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifnl25 interleukin 28A   --   7 (16.80 cM) 28508861 
    chicken
    (Gallus gallus)
    Aves IFNL6
    IFNL6
    interleukin-28B precursor
    34(a)
    34(a)
    many ↔ many
    many ↔ many
    AADN03016676.1(2617-4124)
    AADN03020056.1(8264-9772)


    ENSEMBL Gene Tree for IFNL2 (if available)
    TreeFam Gene Tree for IFNL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFNL2 gene
    IFNL32  IFNL12  
    3 SIMAP similar genes for IFNL2 using alignment to 1 protein entry:     IFNL2_HUMAN:
    IL28A    IFNL3    IFNL1

    IFNL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/139 SNPs in IFNL2 are shown (see all 139)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3749657281,2
    C--39757289(+) CTCCAA/GCTGAG 1 -- us2k10--------
    rs612605631,2
    C--39757560(+) TCCTTC/TGTCAC 1 -- us2k10--------
    rs1930062201,2
    --39757561(+) CCTTCC/GTCACA 1 -- us2k10--------
    rs6648931,2
    C,F,H--39757572(-) AAGAAT/CTGAGG 1 -- us2k112Minor allele frequency- C:0.08NS EA NA 1730
    rs1837491661,2
    --39757758(+) ACTAAA/GAATAC 1 -- us2k10--------
    rs1884234411,2
    --39757873(+) AGATGG/TTGCCT 1 -- us2k10--------
    rs25968071,2
    C,F--39757926(-) gtgagT/CgagCA 1 -- us2k17Minor allele frequency- C:0.44NA WA CSA 247
    rs1131962761,2
    F--39758000(+) ATATAC/TACACA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1511753351,2
    --39758006(+) ACACAC/TACATA 1 -- us2k10--------
    rs755574401,2
    C--39758153(+) AAAATA/TAGTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFNL2 (39759154 - 39760732 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IFNL2: --

    Human Gene Mutation Database (HGMD): IFNL2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNL2
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607401    OMIM disorders: --

    6 diseases for IFNL2:    About MalaCards
    vaginitis    influenza    hepatitis c    melanoma
    hepatitis    neuronitis


    IFNL2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for IFNL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 16618774 (1)


    Export disorders for IFNL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFNL2 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with IFNL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. (PubMed id 16539846)1, 2, 9 Li M.C....He S.H. (2006)
    2. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PubMed id 12469119)1, 2, 9 Sheppard P.... Klucher K.M. (2003)
    3. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PubMed id 12483210)1, 2, 9 Kotenko S.V.... Donnelly R.P. (2003)
    4. IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. (PubMed id 16051921)1, 9 Brand S....Dambacher J. (2005)
    5. Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma. (PubMed id 16618774)1, 9 Lasfar A....Kotenko S.V. (2006)
    6. Biological activity of interleukins-28 and -29: comparison with type I interferons. (PubMed id 15899585)1, 9 Meager A....Wadhwa M. (2005)
    7. Sequence analysis of the IL28A/IL28B inverted gene dup lication that contains polymorphisms associated with treatment response in hepat itis C patients. (PubMed id 22253847)1 Reynolds J.M....Johnston G.I. (2012)
    8. Type III IFNs are produced by and stimulate human plas macytoid dendritic cells. (PubMed id 22891284)1 Yin Z....Fitzgerald-Bocarsly P. (2012)
    9. Role of the p38 MAPK signaling pathway in mediating in terleukin-28A-induced migration of UMUC-3 cells. (PubMed id 22825757)1 Lee S.J....Moon S.K. (2012)
    10. Identification of pro-inflammatory cytokines associate d with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A. (PubMed id 22962576)1 Lee S.J....Moon S.K. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 282616 HGNC: 18364 AceView: IL28A Ensembl:ENSG00000183709 euGenes: HUgn282616
    ECgene: IFNL2 Kegg: 282616 H-InvDB: IFNL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFNL2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_28

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFNL2 gene:
    Search GeneIP for patents involving IFNL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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