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Aliases for IFNL2 Gene

Aliases for IFNL2 Gene

  • Interferon, Lambda 2 2 3
  • IL28A 3 4 6
  • Interleukin 28A (Interferon, Lambda 2) 2 3
  • Cytokine Zcyto20 3 4
  • Interleukin-28A 3 4
  • IFN-Lambda-2 3 4
  • IL-28A 3 4
  • Interferon Lambda 2 3
  • Interferon Lambda-2 3
  • Interferon-Lambda 2 3
  • Interleukin 28A 2
  • ZCYTO20 4

External Ids for IFNL2 Gene

Previous Symbols for IFNL2 Gene

  • IL28A

Summaries for IFNL2 Gene

Entrez Gene Summary for IFNL2 Gene

  • This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNL2 Gene

IFNL2 (Interferon, Lambda 2) is a Protein Coding gene. Among its related pathways are NOD-like Receptor Signaling Pathways and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IFNL3.

UniProtKB/Swiss-Prot for IFNL2 Gene

  • Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNL2 Gene

Genomics for IFNL2 Gene

Genomic Location for IFNL2 Gene

Start:
39,268,514 bp from pter
End:
39,270,092 bp from pter
Size:
1,579 bases
Orientation:
Plus strand

Genomic View for IFNL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNL2 Gene

No data available for Regulatory Elements for IFNL2 Gene

Proteins for IFNL2 Gene

  • Protein details for IFNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZJ0-IFNL2_HUMAN
    Recommended name:
    Interferon lambda-2
    Protein Accession:
    Q8IZJ0
    Secondary Accessions:
    • Q45KQ8
    • Q6VN55
    • Q8IWL7

    Protein attributes for IFNL2 Gene

    Size:
    200 amino acids
    Molecular mass:
    22288 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAR24510.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for IFNL2 Gene

Proteomics data for IFNL2 Gene at MOPED

Post-translational modifications for IFNL2 Gene

No Post-translational modifications

Other Protein References for IFNL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNL2 Gene

Domains for IFNL2 Gene

Gene Families for IFNL2 Gene

HGNC:
  • IFN :Interferons

Protein Domains for IFNL2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

IFNL2_HUMAN
Family:
  • Belongs to the lambda interferon family.:
    • Q8IZJ0
genes like me logo Genes that share domains with IFNL2: view

Function for IFNL2 Gene

Molecular function for IFNL2 Gene

UniProtKB/Swiss-Prot Function: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
UniProtKB/Swiss-Prot Induction: By viral infections or double-stranded RNA.

Gene Ontology (GO) - Molecular Function for IFNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IBA --
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with IFNL2: view

Phenotypes for IFNL2 Gene

GenomeRNAi human phenotypes for IFNL2:
genes like me logo Genes that share phenotypes with IFNL2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNL2 Gene

Localization for IFNL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNL2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for IFNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNL2: view

Pathways for IFNL2 Gene

genes like me logo Genes that share pathways with IFNL2: view

Pathways by source for IFNL2 Gene

1 R&D Systems pathway for IFNL2 Gene
1 Qiagen pathway for IFNL2 Gene
1 BioSystems pathway for IFNL2 Gene

Gene Ontology (GO) - Biological Process for IFNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002385 mucosal immune response ISS --
GO:0007259 JAK-STAT cascade IEA --
GO:0045087 innate immune response IBA --
GO:0050778 positive regulation of immune response IEA --
GO:0050863 regulation of T cell activation IBA --
genes like me logo Genes that share ontologies with IFNL2: view

Compounds for IFNL2 Gene

(2) Novoseek inferred chemical compound relationships for IFNL2 Gene

Compound -log(P) Hits PubMed IDs
2,5-oligoadenylate 72.5 1
poly(i-c) 67 1
genes like me logo Genes that share compounds with IFNL2: view

Transcripts for IFNL2 Gene

mRNA/cDNA for IFNL2 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNL2 Gene

Interferon, lambda 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNL2 Gene

No ASD Table

Relevant External Links for IFNL2 Gene

GeneLoc Exon Structure for
IFNL2
ECgene alternative splicing isoforms for
IFNL2

Expression for IFNL2 Gene

mRNA expression in normal human tissues for IFNL2 Gene

mRNA differential expression in normal tissues according to GTEx for IFNL2 Gene

This gene is overexpressed in Testis (18.7), Pancreas (12.4), Skin - Not Sun Exposed (Suprapubic) (7.5), and Skin - Sun Exposed (Lower leg) (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IFNL2 Gene

SOURCE GeneReport for Unigene cluster for IFNL2 Gene Hs.567792

genes like me logo Genes that share expressions with IFNL2: view

Orthologs for IFNL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNL2 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifnl2 16
Ifnl2 37
  • 64 (a)
ManyToMany
Ifnl3 37
  • 61 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFNL 37
  • 33 (a)
ManyToMany
IFNL 37
  • 33 (a)
ManyToMany
Species with no ortholog for IFNL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNL2 Gene

ENSEMBL:
Gene Tree for IFNL2 (if available)
TreeFam:
Gene Tree for IFNL2 (if available)

Paralogs for IFNL2 Gene

Paralogs for IFNL2 Gene

Selected SIMAP similar genes for IFNL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNL2: view

Variants for IFNL2 Gene

Sequence variations from dbSNP and Humsavar for IFNL2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs30481 -- 39,269,429(+) ATCCT(C/G)CTCCC intron-variant
rs546500 -- 39,269,648(+) TCGTT(A/G)GGGCC intron-variant
rs546501 -- 39,269,647(+) GTCGT(C/T)GGGGC intron-variant
rs553088 -- 39,268,912(-) GTGAC(C/G)CTTGG intron-variant
rs553114 -- 39,268,902(-) GAGTG(C/G)GGGTG intron-variant

Relevant External Links for IFNL2 Gene

HapMap Linkage Disequilibrium report
IFNL2

No data available for Structural Variations from Database of Genomic Variants (DGV) for IFNL2 Gene

Disorders for IFNL2 Gene

(1) Novoseek inferred disease relationships for IFNL2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
genes like me logo Genes that share disorders with IFNL2: view

No data available for UniProtKB/Swiss-Prot for IFNL2 Gene

Publications for IFNL2 Gene

  1. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti- viral effect of IL-28 and IL-29 on WISH cells. (PMID: 16539846) Li M.C. … He S.H. (Acta Pharmacol. Sin. 2006) 3 4 23
  2. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PMID: 12469119) Sheppard P. … Klucher K.M. (Nat. Immunol. 2003) 3 4 23
  3. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PMID: 12483210) Kotenko S.V. … Donnelly R.P. (Nat. Immunol. 2003) 3 4 23
  4. Biological activity of interleukins-28 and -29: comparison with type I interferons. (PMID: 15899585) Meager A. … Wadhwa M. (Cytokine 2005) 3 23
  5. IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. (PMID: 16051921) Brand S. … Dambacher J. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005) 3 23

Products for IFNL2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNL2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFNL2
    • Block miRNA regulation of IFNL2 using miScript Target Protectors

    Sources for IFNL2 Gene

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