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Aliases for IFNL1 Gene

Aliases for IFNL1 Gene

  • Interferon, Lambda 1 2 3 5
  • Interleukin 29 (Interferon, Lambda 1) 2 3
  • Cytokine Zcyto21 3 4
  • Interleukin-29 3 4
  • IFN-Lambda-1 3 4
  • IL-29 3 4
  • IL29 3 4
  • Interferon-Lambda-1 3
  • Interleukin 29 2
  • ZCYTO21 4

External Ids for IFNL1 Gene

Previous HGNC Symbols for IFNL1 Gene

  • IL29

Previous GeneCards Identifiers for IFNL1 Gene

  • GC19P039787

Summaries for IFNL1 Gene

Entrez Gene Summary for IFNL1 Gene

  • This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNL1 Gene

IFNL1 (Interferon, Lambda 1) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor binding and interleukin-28 receptor binding. An important paralog of this gene is IFNL2.

UniProtKB/Swiss-Prot for IFNL1 Gene

  • Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Gene Wiki entry for IFNL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNL1 Gene

Genomics for IFNL1 Gene

Genomic Location for IFNL1 Gene

Chromosome:
19
Start:
39,296,325 bp from pter
End:
39,298,673 bp from pter
Size:
2,349 bases
Orientation:
Plus strand

Genomic View for IFNL1 Gene

Genes around IFNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNL1 Gene

No data available for Regulatory Elements for IFNL1 Gene

Proteins for IFNL1 Gene

  • Protein details for IFNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU54-IFNL1_HUMAN
    Recommended name:
    Interferon lambda-1
    Protein Accession:
    Q8IU54
    Secondary Accessions:
    • A0AV25
    • Q17R34

    Protein attributes for IFNL1 Gene

    Size:
    200 amino acids
    Molecular mass:
    21898 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IFNL1 Gene

neXtProt entry for IFNL1 Gene

Proteomics data for IFNL1 Gene at MOPED

Post-translational modifications for IFNL1 Gene

  • Glycosylation at Asn 65
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IFNL1 (IL-29/IL-28B (IFN-lambda 1/3))
  • R&D Systems Antibodies for IFNL1 (IL-29/IFN-lambda 1)

Protein Products

No data available for DME Specific Peptides for IFNL1 Gene

Domains & Families for IFNL1 Gene

Gene Families for IFNL1 Gene

Protein Domains for IFNL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IU54

UniProtKB/Swiss-Prot:

IFNL1_HUMAN :
  • Belongs to the lambda interferon family.
Family:
  • Belongs to the lambda interferon family.
genes like me logo Genes that share domains with IFNL1: view

Function for IFNL1 Gene

Molecular function for IFNL1 Gene

UniProtKB/Swiss-Prot Function:
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
UniProtKB/Swiss-Prot Induction:
By viral infections or double-stranded RNA.

Phenotypes for IFNL1 Gene

genes like me logo Genes that share phenotypes with IFNL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNL1 Gene

Localization for IFNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNL1 Gene

Secreted.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IFNL1 Gene

Pathways & Interactions for IFNL1 Gene

genes like me logo Genes that share pathways with IFNL1: view

Pathways by source for IFNL1 Gene

SIGNOR curated interactions for IFNL1 Gene

Activates:

Gene Ontology (GO) - Biological Process for IFNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032696 negative regulation of interleukin-13 production IDA 19346497
GO:0032714 negative regulation of interleukin-5 production IDA 19346497
GO:0032729 positive regulation of interferon-gamma production IDA 19346497
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA 15166220
GO:0043381 negative regulation of memory T cell differentiation IDA 19346497
genes like me logo Genes that share ontologies with IFNL1: view

Drugs & Compounds for IFNL1 Gene

(1) Additional Compounds for IFNL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNL1: view

Transcripts for IFNL1 Gene

mRNA/cDNA for IFNL1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNL1 Gene

Interferon, lambda 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNL1 Gene

No ASD Table

Relevant External Links for IFNL1 Gene

GeneLoc Exon Structure for
IFNL1
ECgene alternative splicing isoforms for
IFNL1

Expression for IFNL1 Gene

mRNA expression in normal human tissues for IFNL1 Gene

SOURCE GeneReport for Unigene cluster for IFNL1 Gene Hs.406745

genes like me logo Genes that share expression patterns with IFNL1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFNL1 Gene

Orthologs for IFNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL29 35
  • 80.63 (n)
  • 71.43 (a)
IFNL1 36
  • 40 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL29 35
  • 97.44 (n)
  • 96.92 (a)
IFNL1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 71 (a)
OneToMany
IL29L 36
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFNL 36
  • 32 (a)
ManyToMany
IFNL 36
  • 32 (a)
ManyToMany
Species with no ortholog for IFNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNL1 Gene

ENSEMBL:
Gene Tree for IFNL1 (if available)
TreeFam:
Gene Tree for IFNL1 (if available)

Paralogs for IFNL1 Gene

Paralogs for IFNL1 Gene

(2) SIMAP similar genes for IFNL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNL1: view

Variants for IFNL1 Gene

Sequence variations from dbSNP and Humsavar for IFNL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs30461 - 39,298,475(-) CAGGT(C/T)CCCAT reference, missense
rs856839 -- 39,295,044(-) ggtgg(C/T)tcacg upstream-variant-2KB
rs7246851 -- 39,295,237(+) cctta(C/T)tcagt upstream-variant-2KB
rs7247086 -- 39,295,379(+) AACTA(C/T)TCAGA upstream-variant-2KB
rs7247097 -- 39,295,459(+) Tggcc(A/G)ggagc upstream-variant-2KB

Variation tolerance for IFNL1 Gene

Residual Variation Intolerance Score: 74.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNL1 Gene

HapMap Linkage Disequilibrium report
IFNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IFNL1 Gene

Disorders for IFNL1 Gene

Relevant External Links for IFNL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNL1

No disorders were found for IFNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNL1 Gene

Publications for IFNL1 Gene

  1. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PMID: 12469119) Sheppard P. … Klucher K.M. (Nat. Immunol. 2003) 3 4 23 67
  2. Purification, crystallization and preliminary crystallographic studies of the complex of interferon-lambda1 with its receptor. (PMID: 20057073) Magracheva E. … Zdanov A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010) 3 23
  3. Interleukin-29 binds to melanoma cells inducing Jak-STAT signal transduction and apoptosis. (PMID: 20103601) Guenterberg K.D. … Carson W.E. (Mol. Cancer Ther. 2010) 3 23
  4. Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. (PMID: 19155475) Wang J. … Mason R.J. (J. Immunol. 2009) 3 23
  5. IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells. (PMID: 19346497) Dai J. … Gallagher G. (Blood 2009) 3 23

Products for IFNL1 Gene

Sources for IFNL1 Gene

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