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Aliases for IFNL1 Gene

Aliases for IFNL1 Gene

  • Interferon Lambda 1 2 3 5
  • Interleukin 29 (Interferon, Lambda 1) 2 3
  • Cytokine Zcyto21 3 4
  • Interleukin-29 3 4
  • IFN-Lambda-1 3 4
  • IL-29 3 4
  • IL29 3 4
  • Interferon Lambda-1 3
  • Interleukin 29 2
  • ZCYTO21 4

External Ids for IFNL1 Gene

Previous HGNC Symbols for IFNL1 Gene

  • IL29

Previous GeneCards Identifiers for IFNL1 Gene

  • GC19P039787

Summaries for IFNL1 Gene

Entrez Gene Summary for IFNL1 Gene

  • This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNL1 Gene

IFNL1 (Interferon Lambda 1) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Jak-STAT signaling pathway (KEGG). GO annotations related to this gene include receptor binding and interleukin-28 receptor binding. An important paralog of this gene is IFNL3.

UniProtKB/Swiss-Prot for IFNL1 Gene

  • Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Gene Wiki entry for IFNL1 Gene

Additional gene information for IFNL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNL1 Gene

Genomics for IFNL1 Gene

Regulatory Elements for IFNL1 Gene

Enhancers for IFNL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H039340 1.4 ENCODE dbSUPER 11.7 +45.9 45911 3 DMAP1 YY1 ZNF143 SP3 ZC3H11A NFYC SSRP1 ZNF610 GLIS1 NBN HNRNPL FBL PSMC4 RN7SL566P ENSG00000269688 AKT2 EID2B SUPT5H PAF1 ZNF780A
GH19H039083 1.2 Ensembl ENCODE dbSUPER 10.8 -212.4 -212425 1 ZBTB10 RNF2 YY2 SUZ12 REST ZNF148 ZFHX2 SMARCA4 ZNF341 IKZF1 ACP7 HNRNPL PAK4 IFNL1 GC19P039085
GH19H039351 1.1 ENCODE dbSUPER 10.9 +56.1 56075 2 HDAC1 HDGF CTCF PKNOX1 ATF1 TBL1XR1 ZBTB21 ARNT TAL1 BATF SUPT5H RPS16 ZFP36 PLEKHG2 PAK4 IFNL1 EID2B SAMD4B GMFG GC19P039349
GH19H039347 0.7 dbSUPER 10.9 +51.4 51362 1 HDAC1 PKNOX1 TAL1 ZNF2 FOSL1 TCF12 NCOR1 SCRT2 ZNF600 PRDM10 MED29 PAF1 ZFP36 PLEKHG2 DLL3 IFNL1 PAK4 EID2B GC19P039349 SAMD4B
GH19H039064 0.6 dbSUPER 11 -231.6 -231631 0 ZSCAN21 ZNF366 GLIS1 PATZ1 KLF17 ZIC2 SP7 ACP7 FBXO27 PAK4 FBXO17 IFNL1 SARS2 GC19P039085 GC19M039038
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFNL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNL1 Gene

Chromosome:
19
Start:
39,296,325 bp from pter
End:
39,298,673 bp from pter
Size:
2,349 bases
Orientation:
Plus strand

Genomic View for IFNL1 Gene

Genes around IFNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNL1 Gene

Proteins for IFNL1 Gene

  • Protein details for IFNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU54-IFNL1_HUMAN
    Recommended name:
    Interferon lambda-1
    Protein Accession:
    Q8IU54
    Secondary Accessions:
    • A0AV25
    • Q17R34

    Protein attributes for IFNL1 Gene

    Size:
    200 amino acids
    Molecular mass:
    21898 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IFNL1 Gene

neXtProt entry for IFNL1 Gene

Post-translational modifications for IFNL1 Gene

  • Glycosylation at posLast=6565
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IFNL1 (IL-29/IL-28B (IFN-lambda 1/3))
  • R&D Systems Antibodies for IFNL1 (IL-29/IFN-lambda 1)
  • Abcam antibodies for IFNL1

Protein Products

  • Abcam proteins for IFNL1

Assay Products

  • Abcam assays for IFNL1

No data available for DME Specific Peptides for IFNL1 Gene

Domains & Families for IFNL1 Gene

Gene Families for IFNL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IU54

UniProtKB/Swiss-Prot:

IFNL1_HUMAN :
  • Belongs to the lambda interferon family.
Family:
  • Belongs to the lambda interferon family.
genes like me logo Genes that share domains with IFNL1: view

Function for IFNL1 Gene

Molecular function for IFNL1 Gene

UniProtKB/Swiss-Prot Function:
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
UniProtKB/Swiss-Prot Induction:
By viral infections or double-stranded RNA.

Phenotypes From GWAS Catalog for IFNL1 Gene

Gene Ontology (GO) - Molecular Function for IFNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IDA 12483210
GO:0005125 cytokine activity IEA --
GO:0032003 interleukin-28 receptor binding IPI 12469119
genes like me logo Genes that share ontologies with IFNL1: view

Phenotypes for IFNL1 Gene

genes like me logo Genes that share phenotypes with IFNL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IFNL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNL1 Gene

Localization for IFNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNL1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for IFNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005622 intracellular IEA --
GO:0032002 interleukin-28 receptor complex IDA 12469119
genes like me logo Genes that share ontologies with IFNL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNL1 Gene

Pathways & Interactions for IFNL1 Gene

genes like me logo Genes that share pathways with IFNL1: view

SIGNOR curated interactions for IFNL1 Gene

Activates:

Gene Ontology (GO) - Biological Process for IFNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002829 negative regulation of type 2 immune response IDA 19346497
GO:0007259 JAK-STAT cascade IEA --
GO:0008285 negative regulation of cell proliferation IDA 15166220
GO:0032696 negative regulation of interleukin-13 production IDA 19346497
GO:0032714 negative regulation of interleukin-5 production IDA 19346497
genes like me logo Genes that share ontologies with IFNL1: view

Drugs & Compounds for IFNL1 Gene

(1) Additional Compounds for IFNL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNL1: view

Transcripts for IFNL1 Gene

mRNA/cDNA for IFNL1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNL1 Gene

Interferon, lambda 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IFNL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IFNL1 Gene

No ASD Table

Relevant External Links for IFNL1 Gene

GeneLoc Exon Structure for
IFNL1
ECgene alternative splicing isoforms for
IFNL1

Expression for IFNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNL1 Gene:

IFNL1

SOURCE GeneReport for Unigene cluster for IFNL1 Gene:

Hs.406745
genes like me logo Genes that share expression patterns with IFNL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNL1 Gene

Orthologs for IFNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL29 33
  • 97.44 (n)
IFNL1 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL29 33
  • 80.63 (n)
IFNL1 34
  • 40 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL29L 34
  • 73 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFNL 34 34
  • 32 (a)
ManyToMany
Species where no ortholog for IFNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNL1 Gene

ENSEMBL:
Gene Tree for IFNL1 (if available)
TreeFam:
Gene Tree for IFNL1 (if available)

Paralogs for IFNL1 Gene

Paralogs for IFNL1 Gene

(2) SIMAP similar genes for IFNL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNL1: view

Variants for IFNL1 Gene

Sequence variations from dbSNP and Humsavar for IFNL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000085421 -- 39,299,151(+) CACAT(A/C)ACTGC downstream-variant-500B
rs1000281816 -- 39,297,182(+) TCGTC(C/T)TGCTC intron-variant
rs1000399599 -- 39,295,009(+) CCTGC(C/T)TCAGC upstream-variant-2KB
rs1001627145 -- 39,296,105(+) TCTGC(A/C)ACTCA upstream-variant-2KB
rs1001882774 -- 39,297,312(+) TCTCT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFNL1 Gene

Variant ID Type Subtype PubMed ID
nsv833830 CNV loss 17160897

Variation tolerance for IFNL1 Gene

Residual Variation Intolerance Score: 74.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNL1 Gene

Disorders for IFNL1 Gene

Relevant External Links for IFNL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNL1

No disorders were found for IFNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNL1 Gene

Publications for IFNL1 Gene

  1. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PMID: 12483210) Kotenko SV … Donnelly RP (Nature immunology 2003) 3 4 22 60
  2. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PMID: 12469119) Sheppard P … Klucher KM (Nature immunology 2003) 3 4 22 60
  3. Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1. (PMID: 20934432) Miknis ZJ … Wlodawer A (Journal of molecular biology 2010) 3 4 60
  4. Interleukin-29 binds to melanoma cells inducing Jak-STAT signal transduction and apoptosis. (PMID: 20103601) Guenterberg KD … Carson WE (Molecular cancer therapeutics 2010) 3 22 60
  5. Purification, crystallization and preliminary crystallographic studies of the complex of interferon-lambda1 with its receptor. (PMID: 20057073) Magracheva E … Zdanov A (Acta crystallographica. Section F, Structural biology and crystallization communications 2010) 3 22 60

Products for IFNL1 Gene

Sources for IFNL1 Gene

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