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Aliases for IFNK Gene

Aliases for IFNK Gene

  • Interferon Kappa 2 3
  • Interferon, Kappa 2 3 5
  • IFN-Kappa 3 4
  • Interferon-Like Protein 3
  • IFNT1 3
  • INFE1 3

External Ids for IFNK Gene

Previous GeneCards Identifiers for IFNK Gene

  • GC09P027836
  • GC09P027693

Summaries for IFNK Gene

Entrez Gene Summary for IFNK Gene

  • This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNK Gene

IFNK (Interferon Kappa) is a Protein Coding gene. Diseases associated with IFNK include skin conditions. Among its related pathways are PEDF Induced Signaling and Jak-STAT signaling pathway. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNK Gene

  • May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.

Gene Wiki entry for IFNK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNK Gene

Genomics for IFNK Gene

Regulatory Elements for IFNK Gene

Enhancers for IFNK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFNK on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNK Gene

Chromosome:
9
Start:
27,524,314 bp from pter
End:
27,526,498 bp from pter
Size:
2,185 bases
Orientation:
Plus strand

Genomic View for IFNK Gene

Genes around IFNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNK Gene

Proteins for IFNK Gene

  • Protein details for IFNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0W0-IFNK_HUMAN
    Recommended name:
    Interferon kappa
    Protein Accession:
    Q9P0W0
    Secondary Accessions:
    • Q5T166

    Protein attributes for IFNK Gene

    Size:
    207 amino acids
    Molecular mass:
    25218 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNK Gene

Proteomics data for IFNK Gene at MOPED

Post-translational modifications for IFNK Gene

No Post-translational modifications

Other Protein References for IFNK Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IFNK Gene

Domains & Families for IFNK Gene

Gene Families for IFNK Gene

Suggested Antigen Peptide Sequences for IFNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0W0

UniProtKB/Swiss-Prot:

IFNK_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNK: view

Function for IFNK Gene

Molecular function for IFNK Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.
UniProtKB/Swiss-Prot Induction:
By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.
genes like me logo Genes that share phenotypes with IFNK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IFNK

miRNA for IFNK Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFNK Gene

Localization for IFNK Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNK Gene COMPARTMENTS Subcellular localization image for IFNK gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for IFNK Gene

Pathways & Interactions for IFNK Gene

genes like me logo Genes that share pathways with IFNK: view

Interacting Proteins for IFNK Gene

Gene Ontology (GO) - Biological Process for IFNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 11514542
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
GO:0008285 negative regulation of cell proliferation NAS 11514542
GO:0019221 cytokine-mediated signaling pathway IDA 11514542
genes like me logo Genes that share ontologies with IFNK: view

No data available for SIGNOR curated interactions for IFNK Gene

Drugs & Compounds for IFNK Gene

No Compound Related Data Available

Transcripts for IFNK Gene

mRNA/cDNA for IFNK Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNK Gene

Interferon, kappa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNK Gene

No ASD Table

Relevant External Links for IFNK Gene

GeneLoc Exon Structure for
IFNK
ECgene alternative splicing isoforms for
IFNK

Expression for IFNK Gene

mRNA expression in normal human tissues for IFNK Gene

mRNA differential expression in normal tissues according to GTEx for IFNK Gene

This gene is overexpressed in Whole Blood (x4.9) and Cervix - Ectocervix (x4.9).

Protein differential expression in normal tissues from HIPED for IFNK Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFNK Gene



SOURCE GeneReport for Unigene cluster for IFNK Gene Hs.591083

mRNA Expression by UniProt/SwissProt for IFNK Gene

Q9P0W0-IFNK_HUMAN
Tissue specificity: Expressed in keratinocytes, monocytes and in resting dendritic cells.
genes like me logo Genes that share expression patterns with IFNK: view

Protein tissue co-expression partners for IFNK Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IFNK Gene

Orthologs for IFNK Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFNK 35
  • 79.71 (n)
  • 67.15 (a)
IFNK 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFNK 35
  • 79.71 (n)
  • 71.5 (a)
IFNK 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifnk 35
  • 61.98 (n)
  • 40 (a)
Ifnk 16
Ifnk 36
  • 34 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IFNK 35
  • 98.55 (n)
  • 98.07 (a)
IFNK 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifnk 35
  • 61.59 (n)
  • 42.93 (a)
oppossum
(Monodelphis domestica)
Mammalia IFN9 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFN1 36
  • 32 (a)
ManyToMany
Species with no ortholog for IFNK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNK Gene

ENSEMBL:
Gene Tree for IFNK (if available)
TreeFam:
Gene Tree for IFNK (if available)

Paralogs for IFNK Gene

(6) SIMAP similar genes for IFNK Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNK: view

Variants for IFNK Gene

Sequence variations from dbSNP and Humsavar for IFNK Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_021303 -
VAR_032710 -

Structural Variations from Database of Genomic Variants (DGV) for IFNK Gene

Variant ID Type Subtype PubMed ID
nsv892870 CNV Gain 21882294

Variation tolerance for IFNK Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNK Gene

HapMap Linkage Disequilibrium report
IFNK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNK Gene

Disorders for IFNK Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNK Gene - From: GeneCards

Disorder Aliases PubMed IDs
skin conditions
  • dermatologic disorders
- elite association - COSMIC cancer census association via MalaCards
Search IFNK in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFNK

Genetic Association Database (GAD)
IFNK
Human Genome Epidemiology (HuGE) Navigator
IFNK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNK
genes like me logo Genes that share disorders with IFNK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNK Gene

Publications for IFNK Gene

  1. Interferon-kappa, a novel type I interferon expressed in human keratinocytes. (PMID: 11514542) LaFleur D.W. … Moore P.A. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Epigenetic silencing of interferon-kappa in human papillomavirus type 16-positive cells. (PMID: 19887612) Rincon-Orozco B. … RAPsl F. (Cancer Res. 2009) 3 23
  3. Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system. (PMID: 12391192) Nardelli B. … Moore P.A. (J. Immunol. 2002) 2 3
  4. E2 proteins of high risk human papillomaviruses down-modulate STING and IFN-I_ transcription in keratinocytes. (PMID: 24614210) Sunthamala N. … Ekalaksananan T. (PLoS ONE 2014) 3
  5. A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer. (PMID: 23376709) Kerns S.L. … Rosenstein B.S. (J. Urol. 2013) 3

Products for IFNK Gene

Sources for IFNK Gene

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