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Aliases for IFNK Gene

Aliases for IFNK Gene

  • Interferon, Kappa 2 3
  • IFN-Kappa 3 4
  • Interferon-Like Protein 3
  • Interferon Kappa 3
  • IFNT1 3
  • INFE1 3

External Ids for IFNK Gene

Summaries for IFNK Gene

Entrez Gene Summary for IFNK Gene

  • This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNK Gene

IFNK (Interferon, Kappa) is a Protein Coding gene. Diseases associated with IFNK include skin conditions and dengue hemorrhagic fever. Among its related pathways are Interferon Pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNK Gene

  • May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.

Gene Wiki entry for IFNK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNK Gene

Genomics for IFNK Gene

Genomic Location for IFNK Gene

Start:
27,524,314 bp from pter
End:
27,526,498 bp from pter
Size:
2,185 bases
Orientation:
Plus strand

Genomic View for IFNK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNK Gene

Regulatory Elements for IFNK Gene

Proteins for IFNK Gene

  • Protein details for IFNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0W0-IFNK_HUMAN
    Recommended name:
    Interferon kappa
    Protein Accession:
    Q9P0W0
    Secondary Accessions:
    • Q5T166

    Protein attributes for IFNK Gene

    Size:
    207 amino acids
    Molecular mass:
    25218 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNK Gene

Proteomics data for IFNK Gene at MOPED

Post-translational modifications for IFNK Gene

No Post-translational modifications

Other Protein References for IFNK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNK Gene

Domains for IFNK Gene

Gene Families for IFNK Gene

HGNC:
  • IFN :Interferons

UniProtKB/Swiss-Prot:

IFNK_HUMAN
Family:
  • Belongs to the alpha/beta interferon family.:
    • Q9P0W0
genes like me logo Genes that share domains with IFNK: view

Function for IFNK Gene

Molecular function for IFNK Gene

UniProtKB/Swiss-Prot Function: May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.
UniProtKB/Swiss-Prot Induction: By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.

Gene Ontology (GO) - Molecular Function for IFNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding IDA 11514542
genes like me logo Genes that share ontologies with IFNK: view

Phenotypes for IFNK Gene

genes like me logo Genes that share phenotypes with IFNK: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNK Gene

Localization for IFNK Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNK Gene COMPARTMENTS Subcellular localization image for IFNK gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IC 11514542
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNK: view

Pathways for IFNK Gene

genes like me logo Genes that share pathways with IFNK: view

Interacting Proteins for IFNK Gene

Gene Ontology (GO) - Biological Process for IFNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006355 regulation of transcription, DNA-templated IDA 11514542
GO:0006952 defense response --
genes like me logo Genes that share ontologies with IFNK: view

Transcripts for IFNK Gene

mRNA/cDNA for IFNK Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNK Gene

Interferon, kappa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNK Gene

No ASD Table

Relevant External Links for IFNK Gene

GeneLoc Exon Structure for
IFNK
ECgene alternative splicing isoforms for
IFNK

Expression for IFNK Gene

mRNA expression in normal human tissues for IFNK Gene

mRNA differential expression in normal tissues according to GTEx for IFNK Gene

This gene is overexpressed in Whole Blood (4.9) and Cervix - Ectocervix (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IFNK Gene

SOURCE GeneReport for Unigene cluster for IFNK Gene Hs.591083

mRNA Expression by UniProt/SwissProt for IFNK Gene

Q9P0W0-IFNK_HUMAN
Tissue specificity: Expressed in keratinocytes, monocytes and in resting dendritic cells.
genes like me logo Genes that share expressions with IFNK: view

Orthologs for IFNK Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNK 36
  • 98.55 (n)
  • 98.07 (a)
IFNK 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFNK 36
  • 79.71 (n)
  • 67.15 (a)
IFNK 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFNK 36
  • 79.71 (n)
  • 71.5 (a)
IFNK 37
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifnk 36
  • 61.98 (n)
  • 40 (a)
Ifnk 16
Ifnk 37
  • 34 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IFN9 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFN1 37
  • 32 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifnk 36
  • 61.59 (n)
  • 42.93 (a)
Species with no ortholog for IFNK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNK Gene

ENSEMBL:
Gene Tree for IFNK (if available)
TreeFam:
Gene Tree for IFNK (if available)

Paralogs for IFNK Gene

Selected SIMAP similar genes for IFNK Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNK: view

Variants for IFNK Gene

Sequence variations from dbSNP and Humsavar for IFNK Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_021303 -
VAR_032710 -

Structural Variations from Database of Genomic Variants (DGV) for IFNK Gene

Variant ID Type Subtype PubMed ID
nsv892870 CNV Gain 21882294

Relevant External Links for IFNK Gene

HapMap Linkage Disequilibrium report
IFNK

Disorders for IFNK Gene

(1) Novoseek inferred disease relationships for IFNK Gene

Disease -log(P) Hits PubMed IDs
virus infection 24.2 2

Relevant External Links for IFNK

Genetic Association Database (GAD)
IFNK
Human Genome Epidemiology (HuGE) Navigator
IFNK
genes like me logo Genes that share disorders with IFNK: view

No data available for UniProtKB/Swiss-Prot for IFNK Gene

Publications for IFNK Gene

  1. Interferon-kappa, a novel type I interferon expressed in human keratinocytes. (PMID: 11514542) LaFleur D.W. … Moore P.A. (J. Biol. Chem. 2001) 2 3 4 23
  2. Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system. (PMID: 12391192) Nardelli B. … Moore P.A. (J. Immunol. 2002) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for IFNK Gene

Sources for IFNK Gene

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