IFNK Gene
protein-coding GIFtS: 48
GCID: GC09P027514
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|
interferon, kappa
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Aliases
for IFNK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon, Kappa1 2 | | IFN-Kappa1 | | RP11-27J8.12 | | Interferon Kappa2 | | Interferon-Like Protein2 |
Export aliases for IFNK gene to outside databasesPrevious GC identifers: GC09P027836 GC09P027693 |
Summaries
for IFNK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IFNK:
This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteinsthat play an important role in host defenses against viral infections. This protein is expressed in keratinocytes andthe gene is found on chromosome 9, adjacent to the type I interferon cluster. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IFNK_HUMAN, Q9P0W0Function: May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection againstviral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway.It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin
Gene Wiki entry for IFNK
|
Genomic Views
for IFNK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFNK gene promoter:
AhR AML1a MEF-2 Tal-1beta E47 c-Ets-1 Arnt MEF-2A aMEF-2 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFNK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 9p21.2 HGNC cytogenetic band: 9p21.2IFNK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P027514: view genomic region
(about GC identifiers)
Start:
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27,524,312 bp from pter |
End:
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27,526,496 bp from pter |
Size:
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2,185 bases |
Orientation:
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plus strand |
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Proteins
for IFNK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFNK_HUMAN, Q9P0W0 (See
protein sequence)Recommended Name: Interferon kappa precursor Size: 207 amino acids; 25218 Da
Subcellular location: Secreted
Secondary accessions: Q5T166Explore the universe of human proteins at neXtProt for IFNK: NX_Q9P0W0
IFNK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064509.2
ENSEMBL proteins: ENSP00000276943
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
IFNK for ontologies About GeneDecksing
IFNK Antibody Products:
Assay Products for IFNK: |
Protein
Domains /
Families
for IFNK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFNK for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P0W0ProtoNet protein and cluster: Q9P0W0 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFNK_HUMAN, Q9P0W0Similarity: Belongs to the alpha/beta interferon family |
Function
for IFNK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IFNK_HUMAN, Q9P0W0Function: May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection againstviral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway.It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparinInduction: By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma orinterferon-beta
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNK (NM_020124) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNK |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
IFNK for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for IFNK:
Animal Models:
Mouse knock-out Ifnktm1Lex for IFNK
1 MGI phenotypic allele  for Ifnk (no phenotypes)
IFNK for phenotypes About GeneDecksing
|
Pathways & Interactions
for IFNK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Toll-like receptor signaling pathway | | | 2 | Interferon Pathway | | | 3 | Jak-STAT signaling pathway | | | 4 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | | | 5 | PEDF Induced Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for IFNK
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for IFNK
3 
Kegg Pathways (Kegg details for IFNK):
IFNK for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNK
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for IFNK (ENSP000002769434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
IFNK for ontologies About GeneDecksing
|
Drugs & Compounds
for IFNK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFNK
Search CenterWatch for drugs/clinical trials and news about IFNK
|
Transcripts
for IFNK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFNK gene: NM_020124.2 Unigene Cluster for IFNK: Interferon, kappa Hs.591083 Unigene Representative Sequence: AF1467591 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000276943(uc003zqp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IFNK (NM_020124) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNK |
Additional cDNA sequence: AF146759.1 AF315688.1 AY358855.1 1 DOTS entry: DT.91692638 4 AceView cDNA sequences: AF146759 NM_020124 AF315688 AY358855
GeneLoc Exon Structure
|
Expression
for IFNK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFNK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTTCTCTA
About this image
See IFNK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNK
SOURCE GeneReport for Unigene cluster: Hs.591083
UniProtKB/Swiss-Prot: IFNK_HUMAN, Q9P0W0Tissue specificity: Expressed in keratinocytes, monocytes and in resting dendritic cells
SABiosciences Expression via Pathway-Focused PCR Arrays including IFNK:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFNK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNK |
Orthologs
for IFNK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFNK gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for IFNK (if available)
TreeFam Gene Tree for IFNK (if available) |
Paralogs
for IFNK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IFNK gene
- IFNA12 IFNA212 IFNA72 IFNA22 IFNA172 IFNA42 IFNA62 IFNE2
- IFNA142 IFNB12 IFNW12 IFNA132 IFNA162 IFNA102 IFNA82 IFNA52
6 SIMAP similar genes for IFNK using alignment to 1 protein entry: IFNK_HUMAN:IFNB1 IFNW1 IFNA10 IFNA14 IFNA17 IFNE
IFNK for paralogs About GeneDecksing
|
Genomic Variants
for IFNK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFNK (27524312 - 27526496 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFNK: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNK |
|
Disorders
/ Diseases
for IFNK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFNK for disorders About GeneDecksing
14  diseases for IFNK: About MalaCardsdengue hemorrhagic fever hemorrhagic fever amyotrophic lateral sclerosis skin conditions
lateral sclerosis systemic lupus erythematosus lupus erythematosus atopic dermatitis
rheumatoid arthritis dermatitis arthritis psoriasis
cervicitis melanoma
1 Novoseek disease relationship for IFNK gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| virus infection |
24.2 |
2 |
11514542 (2) |
Human Genome Epidemiology (HuGE) Navigator: IFNK (5 documents)
Export disorders for IFNK gene to outside databases
|
Publications
for IFNK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFNK gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with IFNK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interferon-kappa, a novel type I interferon expressed in human keratinocytes. (PubMed id 11514542)1, 2, 3, 9 LaFleur D.W.... Moore P.A. (2001)
- Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system. (PubMed id 12391192)1, 2, 3 Nardelli B.... Moore P.A. (2002)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Epigenetic silencing of interferon-kappa in human pap illomavirus type 16-positive cells. (PubMed id 19887612)1, 9 Rincon-Orozco B....RAPsl F. (2009)
- High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression. (PubMed id 21849431)1 Reiser J....Stubenrauch F. (2011)
- IFN-I_, a novel type I IFN, is undetectable in HPV-pos itive human cervical keratinocytes. (PubMed id 20479716)1 DeCarlo C.A....Zehbe I. (2010)
- Association of IFIH1 and other autoimmunity risk alle les with selective IgA deficiency. (PubMed id 20694011)1 Ferreira R.C....HammarstrAPm L. (2010)
- Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
|
External Searches for IFNK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFNK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFNK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFNK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IFNK gene:
Search GeneIP for patents involving IFNK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFNK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IFNK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNK | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IFNK | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IFNK | | OriGene Custom Protein Services for IFNK | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNK |
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 |  |  |  | |
| | | | Search Tocris compounds for IFNK |
| |  |  |  |  | | | | |
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 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNK |
|  |  |  | | | | Search ThermoFisher Antibodies for IFNK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNK |
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