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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNK Gene

protein-coding   GIFtS: 50
GCID: GC09P027514

Interferon, Kappa

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Kappa1 2     RP11-27J8.12
IFN-kappa2 3     Interferon Kappa2
IFNT12     Interferon-Like Protein2
INFE12     

External Ids:    HGNC: 217141   Entrez Gene: 568322   Ensembl: ENSG000001478967   OMIM: 6153265   UniProtKB: Q9P0W03   

Export aliases for IFNK gene to outside databases

Previous GC identifers: GC09P027836 GC09P027693


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNK Gene:
This gene encodes a member of the type I interferon family. Type I interferons are a group of related
glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in
keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. (provided by
RefSeq, Jul 2008)

GeneCards Summary for IFNK Gene: 
IFNK (interferon, kappa) is a protein-coding gene. Diseases associated with IFNK include skin conditions, and dengue hemorrhagic fever, and among its related super-pathways are NOD-like Receptor Signaling Pathways and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include interferon-alpha/beta receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNK_HUMAN, Q9P0W0
Function: May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection
against viral infection in a species-specific manner. Activates the interferon-stimulated response element
signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds
heparin

Gene Wiki entry for IFNK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFNK gene promoter:
         AhR   AML1a   MEF-2   Tal-1beta   E47   c-Ets-1   Arnt   MEF-2A   aMEF-2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNK promoter sequence
   Search SABiosciences Chromatin IP Primers for IFNK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  9p21.2   HGNC cytogenetic band: 9p21.2

IFNK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNK gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P027514:  view genomic region     (about GC identifiers)

Start:
27,524,312 bp from pter      End:
27,526,496 bp from pter
Size:
2,185 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFNK_HUMAN, Q9P0W0 (See protein sequence)
Recommended Name: Interferon kappa precursor  
Size: 207 amino acids; 25218 Da
Subcellular location: Secreted
Secondary accessions: Q5T166

Explore the universe of human proteins at neXtProt for IFNK: NX_Q9P0W0

Explore proteomics data for IFNK at MOPED 

IFNK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IFNK Protein Expression

REFSEQ proteins: NP_064509.2  
ENSEMBL proteins: 
 ENSP00000276943  

Human Recombinant Protein Products for IFNK: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IFNK (IFN-alpha K)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec 
OriGene Custom Protein Services for IFNK
GenScript Custom Purified and Recombinant Proteins Services for IFNK
Novus Biologicals IFNK Protein
Novus Biologicals IFNK Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IC11514542
GO:0005615extracellular space IEA--

IFNK for ontologies           About GeneDecksing



IFNK Antibody Products: 
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Novus Biologicals IFNK Antibodies
Abcam antibodies for IFNK
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Search LSBio for Antibodies for IFNK 

Assay Products for IFNK: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IFNK
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for IFNK
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IFN: Interferons

3 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR000471 Interferon_alpha/beta/delta
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry Q9P0W0

ProtoNet protein and cluster: Q9P0W0

1 Blocks protein domain: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNK_HUMAN, Q9P0W0
Similarity: Belongs to the alpha/beta interferon family


IFNK for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IFNK_HUMAN, Q9P0W0
Function: May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection
against viral infection in a species-specific manner. Activates the interferon-stimulated response element
signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds
heparin
Induction: By viral infection, upon exposure to double-stranded RNA, or upon treatment with either
interferon-gamma or interferon-beta

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005126cytokine receptor binding ----
GO:0005132interferon-alpha/beta receptor binding IDA11514542
     
IFNK for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for IFNK:
 Increased circadian period len  Increased gamma-H2AX phosphory 

     1 MGI phenotypic allele for Ifnk (no phenotypes)

IFNK for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Ifnktm1Lex for IFNK

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNK 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNK

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNK 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNK 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNK
3 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNK:
hsa-miR-1303 hsa-miR-3925-5p hsa-miR-493
SwitchGear 3'UTR luciferase reporter plasmidIFNK 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IFNK
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNK

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IFNK
Sirion Biotech Customized adenovirus for overexpression of IFNK

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IFNK (see all 4)
OriGene ORF clones in mouse, rat for IFNK
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNK (NM_020124)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNK
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNK
Sirion Biotech Customized lentivirus for stable overexpression of IFNK 
                     Customized lentivirus expression plasmids for stable overexpression of IFNK 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IFNK
Search LifeMap BioReagents cell lines for IFNK
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNK


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IFNK About                                                                                                See pathways by source

SuperPathContained pathways About
1Toll-Like receptor Signaling Pathways
Toll-Like receptor Signaling Pathways0.59
NOD-like Receptor Signaling Pathways0.59
2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIG-I-like receptor signaling pathway0.52
3PEDF Induced Signaling
Cytokine-cytokine receptor interaction0.43
4Jak-STAT signaling pathway
Jak-STAT signaling pathway
5Interferon Pathway
Interferon Pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 R&D Systems Pathways for IFNK
    NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for IFNK
    Interferon Pathway


3         Kegg Pathways  (Kegg details for IFNK):
    Cytokine-cytokine receptor interaction
RIG-I-like receptor signaling pathway
Jak-STAT signaling pathway


IFNK for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNK

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for IFNK (ENSP000002769434) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IFNAR1ENSP000002701394STRING: ENSP00000270139
IFNAR2ENSP000003439574STRING: ENSP00000343957
About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-dependent IDA11514542
GO:0006952defense response ----
GO:0008285negative regulation of cell proliferation NAS11514542
GO:0009615response to virus IEP11514542
GO:0019221cytokine-mediated signaling pathway IDA11514542

IFNK for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNK

Search CenterWatch for drugs/clinical trials and news about IFNK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNK gene: 
NM_020124.2  

Unigene Cluster for IFNK:

Interferon, kappa
Hs.591083
Unigene Representative Sequence: AF146759
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000276943(uc003zqp.3)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNK
3 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNK:
hsa-miR-1303 hsa-miR-3925-5p hsa-miR-493
SwitchGear 3'UTR luciferase reporter plasmidIFNK 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IFNK
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNK
Clone
Products:
     
OriGene clones in human, mouse for IFNK (see all 4)
OriGene ORF clones in mouse, rat for IFNK
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNK (NM_020124)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNK
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNK
Sirion Biotech Customized lentivirus for stable overexpression of IFNK 
                     Customized lentivirus expression plasmids for stable overexpression of IFNK 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for IFNK
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFNK
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNK
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNK

Additional mRNA sequence: 

AF146759.1 AF315688.1 AY358855.1 

1 DOTS entry:

DT.91692638 

4 AceView cDNA sequences:

AY358855 AF146759 AF315688 NM_020124 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACTTTCTCTA
IFNK Expression
About this image


See IFNK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNK

SOURCE GeneReport for Unigene cluster: Hs.591083

UniProtKB/Swiss-Prot: IFNK_HUMAN, Q9P0W0
Tissue specificity: Expressed in keratinocytes, monocytes and in resting dendritic cells

    SABiosciences Expression via Pathway-Focused PCR Arrays including IFNK: 
          Interferons & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for IFNK
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFNK
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNK
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNK
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNK

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFNK gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ifnk1 , 5 interferon kappa1, 5 61.98(n)1
40(a)1
  4 (17.08 cM)5
3875101  NM_199157.21  NP_954608.11 
 351520565 
chicken
(Gallus gallus)
Aves --
--
(see all 14)
--
35(a)
33(a)
(see all 14)
many ↔ many
many ↔ many
(see all 14)
Z(34143597-34144148)
AADN03019112.1(8049-9473)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 6)
Uncharacterized protein
(see all 6)
31(a)
30(a)
(see all 6)
many ↔ many
many ↔ many
(see all 6)
2(61644933-61645472)
2(61628582-61629115)
zebrafish
(Danio rerio)
Actinopterygii ifnphi26
ifnphi36
interferon phi 3
24(a)
23(a)
many ↔ many
many ↔ many
3(22565711-22572180)
3(22558521-22560658)


ENSEMBL Gene Tree for IFNK (if available)
TreeFam Gene Tree for IFNK (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IFNK gene
IFNA72  IFNA22  IFNA42  IFNE2  IFNA142  IFNA52  IFNA12  IFNA212  
IFNA172  IFNA62  IFNB12  IFNA132  IFNW12  IFNA162  IFNA102  IFNA82  
6 SIMAP similar genes for IFNK using alignment to 1 protein entry:     IFNK_HUMAN:
IFNB1    IFNW1    IFNA10    IFNA14    IFNA17    IFNE

IFNK for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

2 SNPs in IFNK are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0327104
----see VAR_0327102 I N mis40--------
VAR_0213034
----see VAR_0213032 K E mis40--------

HapMap Linkage Disequilibrium report for IFNK (27524312 - 27526496 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for IFNK:    About this table     
Variant IDTypeSubtypePubMed ID
nsv892870CNV Gain21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IFNK
DNA2.0 Custom Variant and Variant Library Synthesis for IFNK

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 615326    OMIM disorders: --

14 diseases for IFNK:    About MalaCards
skin conditions    dengue hemorrhagic fever    hemorrhagic fever    atopic dermatitis
systemic lupus erythematosus    lateral sclerosis    amyotrophic lateral sclerosis    dermatitis
psoriasis    lupus erythematosus    rheumatoid arthritis    arthritis
cervicitis    melanoma


IFNK for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for IFNK gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
virus infection 24.2 2 11514542 (2)

Genetic Association Database (GAD): IFNK
Human Genome Epidemiology (HuGE) Navigator: IFNK (5 documents)

Export disorders for IFNK gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IFNK gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with IFNK)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Interferon-kappa, a novel type I interferon expressed in human keratinocytes. (PubMed id 11514542)1, 2, 3, 9 LaFleur D.W.... Moore P.A. (2001)
  2. Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system. (PubMed id 12391192)1, 2, 3 Nardelli B.... Moore P.A. (2002)
  3. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
  4. Chromosome 9p21 in amyotrophic lateral sclerosis in F inland: a genome-wide association study. (PubMed id 20801718)1, 4 Laaksovirta H....Traynor B.J. (2010)
  5. The role of genetic variation near interferon-kappa i n systemic lupus erythematosus. (PubMed id 20706608)1, 4 Harley I.T....James J.A. (2010)
  6. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)
  7. Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (2010)
  8. Genome-wide association study identifies 19p13.3 (UNC 13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral scleros is. (PubMed id 19734901)1, 4 van Es M.A....van den Berg L.H. (2009)
  9. Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis. (PubMed id 18615156)1, 4 Liu C....Gregersen P.K. (2008)
  10. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 56832 HGNC: 21714 AceView: IFNK Ensembl:ENSG00000147896 euGenes: HUgn56832
ECgene: IFNK Kegg: 56832 H-InvDB: IFNK

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IFNK Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IFNK gene:
Search GeneIP for patents involving IFNK

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore Custom Antibody & Bulk Services
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 Antibodies for IFNK (IFN-kappa)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
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 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
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 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for IFNK (IFN-alpha K)  
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 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IFNK  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for IFNK  
 OriGene qSTAR qPCR primer pairs in human, mouse for IFNK   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for IFNK   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for IFNK   OriGene Custom Protein Services for IFNK  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNK
 QIAGEN SeqTarget long-range PCR primers for resequencing IFNK
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNK
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNK
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 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNK
 GenScript Custom Purified and Recombinant Proteins Services for IFNK GenScript cDNA clones with any tag delivered in your preferred vector for IFNK
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 GenScript Custom overexpressing Cell Line Services for IFNK CloneReady with Over 120,000 Genes
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 Regulatory tfbs in IFNK promoter
 Search Chromatin IP Primers for IFNK
 RT2 qPCR Primer Assay in human, mouse, rat IFNK
 Search GNC Networks for IFNK
 SABiosciences PCR Arrays including human, mouse, rat IFNK
 Search Tocris compounds for IFNK
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 IFNK antibodies
 IFNK proteins
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 Antibodies for IFNK
 See all of Abcam's Antibodies, Kits and Proteins for IFNK
 Custom Antibody / Protein Production Service
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 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for IFNK
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNK
 SwitchGear 3'UTR luciferase reporter plasmids for IFNK
 SwitchGear Promoter luciferase reporter plasmids for IFNK
 Search ThermoFisher Antibodies for IFNK
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNK
 inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNK
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNK
Customized:
 lentivirus for stable overexpression of IFNK
 lentivirus expression plasmids for stable overexpression of IFNK
 adenovirus for overexpression of IFNK
 Search LSBio for Antibodies for IFNK
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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