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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNGR2 Gene

protein-coding   GIFtS: 63
GCID: GC21P034757

Interferon Gamma Receptor 2 (Interferon Gamma Transducer...


(Previous symbol: IFNGT1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Interferon Gamma Receptor 2 (Interferon Gamma Transducer 1)1 2     IFN-Gamma Receptor 22 3
IFNGT11 2 3 5     IFGR22 5
Interferon Gamma Receptor Accessory Factor 12 3     Interferon-Gamma Receptor Beta Chain Precursor11
Interferon Gamma Transducer 12 3     Interferon Gamma Receptor 22
AF-12 3     Interferon Gamma Receptor Accessory Factor-12
IFN-gamma-R22 3     Interferon Gamma Receptor Beta Chain2

External Ids:    HGNC: 54401   Entrez Gene: 34602   Ensembl: ENSG000001591287   OMIM: 1475695   UniProtKB: P384843   

Export aliases for IFNGR2 gene to outside databases

Previous GC identifers: GC21P031352 GC21P031435 GC21P033695 GC21P033697 GC21P020243


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNGR2 Gene:
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human
interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian
susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial
infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked
inheritance. (provided by RefSeq, Jul 2008)

GeneCards Summary for IFNGR2 Gene: 
IFNGR2 (interferon gamma receptor 2 (interferon gamma transducer 1)) is a protein-coding gene. Diseases associated with IFNGR2 include mendelian susceptibility to mycobacterial diseases due to complete ifngammar2 deficiency, and autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency, and among its related super-pathways are Interferon Signaling and Toxoplasmosis. GO annotations related to this gene include interferon-gamma receptor activity. An important paralog of this gene is IFNAR1.

UniProtKB/Swiss-Prot: INGR2_HUMAN, P38484
Function: Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an
integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFNGR2 gene promoter:
         Nkx3-1 v2   Nkx3-1 v4   C/EBPbeta   STAT1   AML1a   Nkx3-1 v3   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IFNGR2 promoter sequence

   Search SABiosciences Chromatin IP Primers for IFNGR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNGR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
IFNGR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNGR2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P034757:   GeneLoc Nature:405,311-319
Start:
34,775,202 bp from pter       20,351,850 bp from centromere
End:
34,851,655 bp from pter 20,386,468 bp from centromere
Size:
76,454 bases 34,619 bases
Orientation:
plus strand plus strand

1 alternative location:
Chr21+,NW_003315970 9,452-32,094     

Whole chromosome sequencing:
cDNA sequence: U05875
genomic clones: PQ102G11 PPACB5


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INGR2_HUMAN, P38484 (See protein sequence)
Recommended Name: Interferon gamma receptor 2 precursor  
Size: 337 amino acids; 37806 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9BTL5

Explore the universe of human proteins at neXtProt for IFNGR2: NX_P38484

Explore proteomics data for IFNGR2 at MOPED 

IFNGR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IFNGR2 Protein Expression

REFSEQ proteins: NP_005525.2  
ENSEMBL proteins: 
 ENSP00000290219   ENSP00000407541   ENSP00000371425   ENSP00000442735   ENSP00000385044  
 ENSP00000402629  
Reactome Protein details: P38484
Human Recombinant Protein Products for IFNGR2: 
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Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for IFNGR2
OriGene Protein Over-expression Lysate for IFNGR2
OriGene MassSpec for IFNGR2 
OriGene Custom Protein Services for IFNGR2
GenScript Custom Purified and Recombinant Proteins Services for IFNGR2
Novus Biologicals IFNGR2 Proteins
Novus Biologicals IFNGR2 Lysates
Sino Biological Recombinant Protein for IFNGR2
Sino Biological Cell Lysate for IFNGR2 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA16780588
GO:0005886plasma membrane TAS--
GO:0005887integral to plasma membrane TAS8910544

IFNGR2 for ontologies           About GeneDecksing



IFNGR2 Antibody Products: 
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R&D Systems Antibodies for IFNGR2 (IFN-gamma R2)
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Novus Biologicals IFNGR2 Antibodies
Abcam antibodies for IFNGR2
Browse Antibodies at Cloud-Clone Corp. 
Search ThermoFisher Antibodies for IFNGR2
LSBio Antibodies in human, mouse, rat for IFNGR2 

Assay Products for IFNGR2: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IFNGR2
R&D Systems Proteome Profiler Antibody Arrays for IFNGR2 (IFN-gamma R2)
GenScript Custom Assay Services for IFNGR2
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
FN3: Fibronectin type III domain containing
IFN: Interferons

IUPHAR Guide to PHARMACOLOGY protein family classification: Interferon γ receptor 2 
Interferon receptor family

3 InterPro protein domains:
 IPR003961 Fibronectin_type3
 IPR015373 Interferon_alpha/beta_rcpt_bsu
 IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry P38484

ProtoNet protein and cluster: P38484

UniProtKB/Swiss-Prot: INGR2_HUMAN, P38484
Similarity: Belongs to the type II cytokine receptor family
Similarity: Contains 2 fibronectin type-III domains


IFNGR2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: INGR2_HUMAN, P38484
Function: Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an
integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2

     Genatlas biochemistry entry for IFNGR2:
interferon gamma receptor 2,56kDa,accessory factor

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004906interferon-gamma receptor activity TAS9616207
GO:0005515protein binding ----
     
IFNGR2 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for IFNGR2:
 Decreased influenza A/WSN/33 r 

     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ifngr2):
 cellular  hematopoietic system  homeostasis/metabolism  immune system 

IFNGR2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Ifngr2tm1Pbro for IFNGR2

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNGR2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNGR2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNGR2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNGR2 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNGR2
1 QIAGEN miScript miRNA Assays for microRNA that regulate IFNGR2:
hsa-miR-4255
SwitchGear 3'UTR luciferase reporter plasmidIFNGR2 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IFNGR2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNGR2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IFNGR2
Sirion Biotech Customized adenovirus for overexpression of IFNGR2

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IFNGR2 (see all 7)
OriGene ORF clones in mouse, rat for IFNGR2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNGR2 (NM_005534)
Sino Biological Human cDNA Clone for IFNGR2
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNGR2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNGR2
Sirion Biotech Customized lentivirus for stable overexpression of IFNGR2 
                     Customized lentivirus expression plasmids for stable overexpression of IFNGR2 

Cell Line
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GenScript Custom overexpressing Cell Line Services for IFNGR2
Search LifeMap BioReagents cell lines for IFNGR2
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNGR2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IFNGR2 About   (see all 25)                                                                                              See pathways by source

SuperPathContained pathways About
1Interferon Signaling
Interferon Signaling0.61
Interferon gamma signaling0.41
Cytokine Signaling in Immune system0.61
2Leishmaniasis
Leishmaniasis0.36
Inflammatory bowel disease (IBD)0.34
Toxoplasmosis0.36
3Influenza A
Influenza A0.34
Herpes simplex infection0.33
Measles0.34
4Immune response Bacterial infections in normal airways
Immune response Bacterial infections in normal airways0.78
5TGF-Beta Pathway
JAK-STAT Pathway0.57

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for IFNGR2
    Immune response IFN gamma signaling pathway

1 R&D Systems Pathway for IFNGR2
    Th1 Differentiation

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNGR2 (see all 8)
    THC Differentiation Pathway
HMGB1 Pathway
Interferon Pathway
JAK-STAT Pathway
Cellular Transformation by HTLV1

2 GeneGo (Thomson Reuters) Pathways for IFNGR2
    Immune response Bacterial infections in normal airways
Immune response IFN gamma signaling pathway

1 BioSystems Pathway for IFNGR2
    Type II interferon signaling (IFNG)


5        Reactome Pathways for IFNGR2
    Interferon gamma signaling
Regulation of IFNG signaling
Cytokine Signaling in Immune system
Interferon Signaling
Immune System


5/14         Kegg Pathways  (Kegg details for IFNGR2) (see all 14):
    Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Osteoclast differentiation
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity


IFNGR2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFNGR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/42 Interacting proteins for IFNGR2 (P384843 ENSP000002902194) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
InteractantInteraction Details
GeneCardExternal ID(s)
IFNGP015793, ENSP000002291354I2D: score=4 STRING: ENSP00000229135
DNAJA3Q96EY13, ENSP000002623754I2D: score=2 STRING: ENSP00000262375
NR3C1P041503, ENSP000002315094I2D: score=2 STRING: ENSP00000231509
JAK2O606743, ENSP000003710674I2D: score=3 STRING: ENSP00000371067
ANXA5P087583, ENSP000002965114I2D: score=3 STRING: ENSP00000296511
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007166cell surface receptor signaling pathway TAS9616207
GO:0009615response to virus TAS8124716
GO:0019221cytokine-mediated signaling pathway TAS--
GO:0060333interferon-gamma-mediated signaling pathway TAS--
GO:0060334regulation of interferon-gamma-mediated signaling pathway TAS--

IFNGR2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IFNGR2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNGR2 (INGR2)

1 DrugBank Compound for IFNGR2    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Interferon gamma-1bIFN-gamma (see all 3)82115-62-6targetbinder17618444 11752352 17239631

7 Novoseek inferred chemical compound relationships for IFNGR2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
4-hydroxytamoxifen 68.5 2 7721882 (1), 12738788 (1)
estrogen 62.4 25 7721882 (3), 11075817 (2), 15078875 (2), 11139588 (1) (see all 16)
tamoxifen 45.5 9 12738788 (2), 20332105 (2), 15060164 (1), 11553641 (1)
retinoic acid 35.6 3 11741282 (1), 7559520 (1), 10866321 (1)
steroid 33.6 6 16771709 (1), 8816752 (1), 20332105 (1), 19811234 (1)
estradiol 27.1 6 20332105 (2), 7721882 (1), 10908317 (1), 8816752 (1)
testosterone 11.9 5 12039962 (1), 12943705 (1), 17342748 (1), 15215582 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about IFNGR2 / INGR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNGR2 gene: 
NM_005534.3  

Unigene Cluster for IFNGR2:

Interferon gamma receptor 2 (interferon gamma transducer 1)
Hs.634632  [show with all ESTs]
Unigene Representative Sequence: NM_005534
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000290219(uc002yrp.4) ENST00000439213 ENST00000381995 ENST00000545369
ENST00000405436 ENST00000421802

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNGR2
1 QIAGEN miScript miRNA Assays for microRNA that regulate IFNGR2:
hsa-miR-4255
SwitchGear 3'UTR luciferase reporter plasmidIFNGR2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IFNGR2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNGR2
Clone
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OriGene clones in human, mouse for IFNGR2 (see all 7)
OriGene ORF clones in mouse, rat for IFNGR2
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GenScript: all cDNA clones in your preferred vector: IFNGR2 (NM_005534)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNGR2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNGR2
Sirion Biotech Customized lentivirus for stable overexpression of IFNGR2 
                     Customized lentivirus expression plasmids for stable overexpression of IFNGR2 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IFNGR2
OriGene qSTAR qPCR primer pairs in human, mouse for IFNGR2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFNGR2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNGR2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNGR2

Additional mRNA sequence: 

AK292246.1 AK314005.1 BC003624.2 DQ655977.2 EF173886.1 U05875.1 U05877.1 

18 DOTS entries:

DT.453988  DT.100818065  DT.100803533  DT.100818058  DT.121131357  DT.121131351  DT.100818051  DT.95169080 
DT.95169097  DT.121131352  DT.75158328  DT.100709397  DT.100818060  DT.100837977  DT.121131362  DT.91856358 
DT.415722  DT.75146865 

24/482 AceView cDNA sequences (see all 482):

BC003624 BU195495 CR607841 CR596056 BI761952 CR617691 CD105546 BM924333 
AI793330 F03847 F07599 CR607346 AI342299 CR600779 CR617094 CR621659 
AA370611 BQ427642 AI424369 AI088757 BE796743 T89516 CA434861 BG235915 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for IFNGR2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1:                    -                                       
SP2:                                                            
SP3:                    -     -     -                           
SP4:        -           -                                       


ECgene alternative splicing isoforms for IFNGR2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNGR2 expression in normal human tissues (normalized intensities)      IFNGR2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGTGCTGGC
IFNGR2 Expression
About this image


IFNGR2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/10 selected tissues (see all 10) fully expand
 
 Brain (Nervous System)    fully expand to see all 7 entries
         Cerebral Cortex
         ganglion/cranial   
 
 Heart (Cardiovascular System)    fully expand to see all 2 entries
         heart/atrium   
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Metencephalon
 
 Peripheral Nervous System (Nervous System)
         spinal/ganglion/dorsal root ganglion   
 
 Spinal Cord (Nervous System)
         spinal/ganglion/dorsal root ganglion   

See IFNGR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNGR2

SOURCE GeneReport for Unigene cluster: Hs.634632
    SABiosciences Expression via Pathway-Focused PCR Arrays including IFNGR2: 
          Interferons & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Allergy & Asthma in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IFNGR2
OriGene qSTAR qPCR primer pairs in human, mouse for IFNGR2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFNGR2
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNGR2
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNGR2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNGR2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFNGR2 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ifngr21 , 5 interferon gamma receptor 21, 5 68.9(n)1
60.67(a)1
  16 (53.07 cM)5
159801  NM_008338.31  NP_032364.11 
 915470725 
chicken
(Gallus gallus)
Aves IFNGR21 interferon gamma receptor 2 (interferon gamma transducer 1) less 47.87(n)
35.64(a)
  418502  NM_001008676.2  NP_001008676.1 
lizard
(Anolis carolinensis)
Reptilia IFNGR26
Uncharacterized protein
30(a)
1 ↔ 1
3(143172671-143181968)
zebrafish
(Danio rerio)
Actinopterygii crfb156
crfb46
(see all 3)
cytokine receptor family member b4
(see all 3)
18(a)
18(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
1(9987516-9991549)
9(16524497-16651219)


ENSEMBL Gene Tree for IFNGR2 (if available)
TreeFam Gene Tree for IFNGR2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IFNGR2 gene
IFNAR12  ENSG000002496242  IL10RB2  

IFNGR2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/865 SNPs in IFNGR2 are shown (see all 865)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0232814
Mendelian susceptibility to mycobacterial disease (MSMD)4--see VAR_0232812 T N mis40--------
rs743154441,2
Cpathogenic125346035(+) TGATAA/CCTCCA 2 N T mis10--------
rs1219131931,2
Cuntested125330272(+) TGAAAC/TGGAAA 1 -- int10--------
rs49869581,2,4
C,F,Huntested125334043(+) TAGCAC/GGAGGC 2 T R mis136Minor allele frequency- G:0.06MN NA NS EA WA EU 8883
rs1219131991,2
Cuntested125340458(+) CCTGCA/GTTTTG 1 -- int10--------
rs1219132071,2
Cuntested125345920(+) TGTGGC/TTTTCT 1 -- int10--------
rs1219132081,2
C,Funtested125345998(+) CCCTCA/CTCATC 2 I L mis12Minor allele frequency- C:0.00NA EU 5823
rs1219132091,2
Cuntested125346042(+) TCCACA/GGCCTT 2 T syn10--------
rs1219132101,2
Cuntested125346060(+) TATTAC/TGTCCA 2 Y syn10--------
rs1219132111,2
Cuntested125351146(+) GTTGTC/TGTGTT 1 -- int10--------

HapMap Linkage Disequilibrium report for IFNGR2 (34775202 - 34851655 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for IFNGR2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv913723CNV Loss21882294
nsv913724CNV Loss21882294
nsv834087CNV Gain17160897


Human Gene Mutation Database (HGMD): IFNGR2

Locus Specific Mutation Databases (LSDB): IFNGR2
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IFNGR2
DNA2.0 Custom Variant and Variant Library Synthesis for IFNGR2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147569   
OMIM disorders: 209950  
UniProtKB/Swiss-Prot: INGR2_HUMAN, P38484
  • Mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]: This rare condition confers
    predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin
    (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium
    tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to
    mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The
    pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity
    determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like
    lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with
    tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant
    or X-linked inheritance. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/57 diseases for IFNGR2 (see all 57):    About MalaCards
    mendelian susceptibility to mycobacterial diseases due to complete ifngammar2 deficiency    autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency    autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency    familial atypical mycobacteriosis, ifngr2-related
    lepromatous leprosy    subacute sclerosing panencephalitis    leprosy    pulmonary sarcoidosis
    sarcoidosis    cblc    trypanosomiasis    acute graft versus host disease
    hepatitis b virus infection    toxoplasmosis    chagas disease    dengue hemorrhagic fever
    pulmonary tuberculosis    myocarditis    chronic myeloid leukemia    hemorrhagic fever


    IFNGR2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for IFNGR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mycobacterial infection 57.6 1 16951322 (1)
    sezary syndrome 46.9 2 9613981 (1), 8695857 (1)
    asthma allergic 32.3 4 11240951 (2), 19247692 (1), 10491309 (1)
    breast cancer 27.3 2 12738788 (1)
    sarcoidosis 20.9 3 15004750 (1), 17937105 (1)
    tuberculosis 0.401 1 15004750 (1)
    asthma 0 1 19247692 (1)
    tumors 0 4 12738788 (1), 9792714 (1), 11553641 (1)

    Genetic Association Database (GAD): IFNGR2
    Human Genome Epidemiology (HuGE) Navigator: IFNGR2 (44 documents)

    Export disorders for IFNGR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFNGR2 gene, integrated from 9 sources (see all 174):
    (articles sorted by number of sources associating them with IFNGR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The interferon-gamma receptor gene polymorphisms (Val14Met and Gln64Arg) are not associated with systemic lupus erythematosus in Chinese patients. (PubMed id 17618444)1, 4, 7, 9 Yao X....Liu J. (2007)
    2. Polymorphisms in the genes encoding interferon-gamma and interferon-gamma receptors in multiple sclerosis. (PubMed id 15182327)1, 4, 9 Schrijver H.M....Uitdehaag B.M. (2004)
    3. Analyses of associations with asthma in four asthma population samples from Canada and Australia. (PubMed id 19247692)1, 4, 9 Daley D....Hudson T.J. (2009)
    4. Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis. (PubMed id 16690980)1, 4, 9 Cooke G.S....Hill A.V. (2006)
    5. Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma. (PubMed id 11240951)1, 4, 9 Nakao F....Hara T. (2001)
    6. Genetic polymorphism of interferon-gamma, interferon-gamma receptor, and interferon regulatory factor-1 genes in patients with hepatitis B virus infection. (PubMed id 16944293)1, 4, 9 Cheong J.Y....Kim J.H. (2006)
    7. Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations. (PubMed id 15924140)1, 2, 9 Vogt G.... Casanova J.-L. (2005)
    8. Interferon-gamma and interferon-gamma receptor 1 and 2 gene polymorphisms and restenosis following coronary stenting. (PubMed id 16115485)1, 4, 9 Tiroch K....Kastrati A. (2005)
    9. Association between IFNA genotype and the risk of sarcoidosis. (PubMed id 15004750)1, 4, 9 Akahoshi M....Shirakawa T. (2004)
    10. Hepatitis B viraemia: its heritability and associatio n with common genetic variation in the interferon {gamma} signalling pathway. (PubMed id 20980339)1, 4 Huang H.H....Yu M.W. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3460 HGNC: 5440 AceView: IFNGR2 Ensembl:ENSG00000159128 euGenes: HUgn3460
    ECgene: IFNGR2 Kegg: 3460 H-InvDB: IFNGR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFNGR2 Pharmacogenomics, SNPs, Pathways
    IFNGR2basehttp://bioinf.uta.fi/IFNGR2base/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/IFNGR2
    SeattleSNPshttp://pga.gs.washington.edu/data/ifngr2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFNGR2 gene:
    Search GeneIP for patents involving IFNGR2

    GeneCards and IP:
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