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Aliases for IFNGR2 Gene

Aliases for IFNGR2 Gene

  • Interferon Gamma Receptor 2 (Interferon Gamma Transducer 1) 2 3
  • IFNGT1 3 4 6
  • Interferon Gamma Receptor Accessory Factor 1 3 4
  • Interferon Gamma Transducer 1 3 4
  • IFN-Gamma Receptor 2 3 4
  • IFN-Gamma-R2 3 4
  • IFGR2 3 6
  • AF-1 3 4
  • Interferon Gamma Receptor Accessory Factor-1 3
  • Interferon Gamma Receptor Beta Chain 3
  • Interferon Gamma Receptor 2 3
  • IMD28 3

External Ids for IFNGR2 Gene

Previous HGNC Symbols for IFNGR2 Gene

  • IFNGT1

Previous GeneCards Identifiers for IFNGR2 Gene

  • GC21P031352
  • GC21P031435
  • GC21P033695
  • GC21P033697
  • GC21P034757
  • GC21P020243

Summaries for IFNGR2 Gene

Entrez Gene Summary for IFNGR2 Gene

  • This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNGR2 Gene

IFNGR2 (Interferon Gamma Receptor 2 (Interferon Gamma Transducer 1)) is a Protein Coding gene. Diseases associated with IFNGR2 include immunodeficiency 28, mycobacteriosis and familial atypical mycobacteriosis, ifngr2-related. Among its related pathways are TGF-Beta Pathway and Interferon Pathway. GO annotations related to this gene include interferon-gamma receptor activity.

UniProtKB/Swiss-Prot for IFNGR2 Gene

  • Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNGR2 Gene

Genomics for IFNGR2 Gene

Regulatory Elements for IFNGR2 Gene

Genomic Location for IFNGR2 Gene

33,402,896 bp from pter
33,479,348 bp from pter
76,453 bases
Plus strand

Genomic View for IFNGR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNGR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNGR2 Gene

Proteins for IFNGR2 Gene

  • Protein details for IFNGR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon gamma receptor 2
    Protein Accession:
    Secondary Accessions:
    • Q9BTL5

    Protein attributes for IFNGR2 Gene

    337 amino acids
    Molecular mass:
    37806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNGR2 Gene

Proteomics data for IFNGR2 Gene at MOPED

Post-translational modifications for IFNGR2 Gene

  • Glycosylation at Asn56, Asn85, Asn110, Asn137, Asn219, and Asn231
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNGR2 Gene

No data available for DME Specific Peptides for IFNGR2 Gene

Domains for IFNGR2 Gene

Gene Families for IFNGR2 Gene

  • FN3 :Fibronectin type III domain containing
  • IFN :Interferons

Protein Domains for IFNGR2 Gene

Graphical View of Domain Structure for InterPro Entry



  • P38484
  • Contains 2 fibronectin type-III domains.
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IFNGR2: view

Function for IFNGR2 Gene

Molecular function for IFNGR2 Gene

GENATLAS Biochemistry: interferon gamma receptor 2,56kDa,accessory factor
UniProtKB/Swiss-Prot Function: Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2

Gene Ontology (GO) - Molecular Function for IFNGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA --
GO:0004906 interferon-gamma receptor activity TAS 9616207
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IFNGR2: view

Phenotypes for IFNGR2 Gene

genes like me logo Genes that share phenotypes with IFNGR2: view

Animal Models for IFNGR2 Gene

MGI Knock Outs for IFNGR2:

miRNA for IFNGR2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IFNGR2 Gene

Localization for IFNGR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNGR2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IFNGR2 Gene COMPARTMENTS Subcellular localization image for IFNGR2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
extracellular 2
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IFNGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16780588
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8910544
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with IFNGR2: view

Pathways for IFNGR2 Gene

genes like me logo Genes that share pathways with IFNGR2: view

Gene Ontology (GO) - Biological Process for IFNGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 9616207
GO:0009615 response to virus TAS 8124716
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IFNGR2: view

Compounds for IFNGR2 Gene

(1) Drugbank Compounds for IFNGR2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Interferon gamma-1b
  • IFN-gamma
82115-62-6 target binder

(7) Novoseek inferred chemical compound relationships for IFNGR2 Gene

Compound -log(P) Hits PubMed IDs
4-hydroxytamoxifen 68.5 2
estrogen 62.4 20
tamoxifen 45.5 6
retinoic acid 35.6 3
steroid 33.6 4
genes like me logo Genes that share compounds with IFNGR2: view

Transcripts for IFNGR2 Gene

Unigene Clusters for IFNGR2 Gene

Interferon gamma receptor 2 (interferon gamma transducer 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNGR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP3: - - -
SP4: - -

Relevant External Links for IFNGR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNGR2 Gene

mRNA expression in normal human tissues for IFNGR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFNGR2 Gene

This gene is overexpressed in Whole Blood (9.1).

SOURCE GeneReport for Unigene cluster for IFNGR2 Gene Hs.634632

genes like me logo Genes that share expressions with IFNGR2: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for IFNGR2 Gene

Orthologs for IFNGR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNGR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNGR2 35
  • 99.31 (n)
  • 98.81 (a)
  • 99 (a)
(Bos Taurus)
Mammalia IFNGR2 35
  • 74.84 (n)
  • 64.78 (a)
  • 60 (a)
(Canis familiaris)
Mammalia -- 36
  • 71 (a)
-- 36
  • 68 (a)
LOC100856276 35
  • 79.14 (n)
  • 72.96 (a)
(Mus musculus)
Mammalia Ifngr2 35
  • 68.87 (n)
  • 61.06 (a)
Ifngr2 16
Ifngr2 36
  • 60 (a)
(Monodelphis domestica)
Mammalia IFNGR2 36
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia IFNGR2 36
  • 43 (a)
(Rattus norvegicus)
Mammalia Ifngr2 35
  • 70.42 (n)
  • 61.92 (a)
(Gallus gallus)
Aves IFNGR2 35
  • 48.31 (n)
  • 36.7 (a)
  • 31 (a)
(Anolis carolinensis)
Reptilia IFNGR2 36
  • 31 (a)
Species with no ortholog for IFNGR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNGR2 Gene

Gene Tree for IFNGR2 (if available)
Gene Tree for IFNGR2 (if available)

Paralogs for IFNGR2 Gene

No data available for Paralogs for IFNGR2 Gene

Variants for IFNGR2 Gene

Sequence variations from dbSNP and Humsavar for IFNGR2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs743333 -- 33,421,910(-) caagt(A/G)gtggg intron-variant
rs2012075 -- 33,424,455(+) CTGGG(C/T)TGCTG intron-variant
rs2012119 -- 33,424,939(+) agttt(C/T)actct intron-variant
rs2070386 -- 33,415,331(+) AAGAA(A/C)AGGAG intron-variant
rs2268241 -- 33,408,744(+) ACTAT(A/G)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFNGR2 Gene

Variant ID Type Subtype PubMed ID
nsv834087 CNV Gain 17160897
nsv913723 CNV Loss 21882294
nsv913724 CNV Loss 21882294

Relevant External Links for IFNGR2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNGR2 Gene

Disorders for IFNGR2 Gene

(1) OMIM Diseases for IFNGR2 Gene (147569)


  • Immunodeficiency 28 (IMD28) [MIM:614889]: A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD28 manifests early in life, with severe, often fatal, infection. {ECO:0000269 PubMed:15924140}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(8) Novoseek inferred disease relationships for IFNGR2 Gene

Disease -log(P) Hits PubMed IDs
mycobacterial infection 57.6 1
sezary syndrome 46.9 2
asthma allergic 32.3 4
breast cancer 27.3 1
sarcoidosis 20.9 2

Relevant External Links for IFNGR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IFNGR2: view

Publications for IFNGR2 Gene

  1. The interferon-gamma receptor gene polymorphisms (Val14Met and Gln64Arg) are not associated with systemic lupus erythematosus in Chinese patients. (PMID: 17618444) Yao X. … Liu J. (Arch. Dermatol. Res. 2007) 3 23 25 48
  2. Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma. (PMID: 11240951) Nakao F. … Hara T. (J. Allergy Clin. Immunol. 2001) 3 23 48
  3. Association between IFNA genotype and the risk of sarcoidosis. (PMID: 15004750) Akahoshi M. … Shirakawa T. (Hum. Genet. 2004) 3 23 48
  4. Polymorphisms in the genes encoding interferon-gamma and interferon-gamma receptors in multiple sclerosis. (PMID: 15182327) Schrijver H.M. … Uitdehaag B.M. (Eur. J. Immunogenet. 2004) 3 23 48
  5. Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations. (PMID: 15924140) Vogt G. … Casanova J.-L. (Nat. Genet. 2005) 3 4 23

Products for IFNGR2 Gene

Sources for IFNGR2 Gene

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