IFNG Gene

Aliases &
Descriptions
for IFNG gene

Previous GC identifers: GC12M068064 GC12M068352 GC12M068265 GC12M066834

Summaries
for IFNG gene

Genomic Views
for IFNG gene

IFNG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M068548:  view genomic region     (about GC identifiers)

RefSeq DNA sequence:

NC_000012.11  NT_029419.12  

Proteins
for IFNG gene

PDB structures from and Proteopedia :

1EKU (3D)    1FG9 (3D)    1FYH (3D)    1HIG (3D)    3BES (3D)    

Post-translational modifications:

	Millipore Purified and/or Recombinant IFNG Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IFNG (IFN-gamma)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	HuPro® and/or Recombinant Proteins from Abnova for IFNG
	Browse Origene full length recombinant human proteins expressed in human HEK293 cells
	Novus Biologicals Proteins for IFNG
	Novus Biologicals Lysates for IFNG
	Browse Sino Biological Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

	Millipore Mono- and Polyclonal Antibodies for the study of IFNG
	Sigma-Aldrich Antibodies for IFNG
	R&D Systems Antibodies for IFNG (IFN-gamma)
	Cell Signaling Technology (CST) Antibodies for IFNG  (IFN-gamma)
	Monoclonal and Polyclonal Antibodies from Abnova (IFNG)
	Origene Antibodies: IFNG
	Novus Biologicals Antibodies for IFNG
	Epitomics antibodies for IFNG

	Millipore Kits and Assays for the Analysis of IFNG
	Browse ELISAs at Sigma-Aldrich
	R&D Systems ELISAs for IFNG (IFN-gamma)         (see all)
	Browse Enzo Life Sciences for kits & assays

Protein Domains/
Families
for IFNG gene

ProtoNet protein and cluster: P01579

Gene Function
for IFNG gene

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products
		Origene 29mer shRNA kits in GFP-retroviral vector: IFNG Origene shRNA RFP: IFNG Origene basic RS shRNA: IFNG
		Applied Biosystems Silencer® siRNAs for IFNG
		Sigma-Aldrich siRNA Panels and siRNA for IFNG Sigma-Aldrich shRNA Panels and shRNA for IFNG Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector: IFNG Origene Myc/DDK tagged cDNA clones in CMV expression vector: IFNG Origene untagged cDNA clones in CMV expression vector: IFNG
		Browse Sino Biological Human cDNA Clones

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

Animal Models: 15/18 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ifng) (see all 18 ):

Pathways & Interactions
for IFNG gene

5/8 Millipore Pathways for IFNG

	Immune response IFN gamma signaling pathway
	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Immune response Role of integrins in NK cells cytotoxicity
	Immune response CD16 signaling in NK cells
	Immune response IL-12-induced IFN-gamma production

5/22 Sigma-Aldrich "Your Favorite Gene" Pathways for  IFNG  (Your Favorite Gene powered by Ingenuity)

	Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
	Crosstalk between Dendritic Cells and Natural Killer Cells
	Colorectal Cancer Metastasis Signaling
	HMGB1 Signaling
	Neuroprotective Role of THOP1 in Alzheimer's Disease

5/18 GeneAssist Pathways for IFNG

	Murine MSP-STK Signaling
	HMGB1 Pathway
	Interferon Pathway
	Colorectal Cancer Metastasis
	Virus-Induced Airway Inflammation

5/12 Kegg Pathways  (Kegg details for IFNG)

	hsa03050 Proteasome
	hsa04060 Cytokine-cytokine receptor interaction
	hsa04140 Regulation of autophagy
	hsa04350 TGF-beta signaling pathway
	hsa04630 Jak-STAT signaling pathway

5/43 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 43 ):

Drugs & Compounds
for IFNG gene

Transcripts
for IFNG gene

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products
		Applied Biosystems Silencer® siRNAs:  NM_000619
		Origene 29mer shRNA kits in GFP-retroviral vector: IFNG Origene shRNA RFP: IFNG Origene basic RS shRNA: IFNG
		Sigma-Aldrich siRNA Panels and siRNA for IFNG Sigma-Aldrich shRNA Panels and shRNA for IFNG Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:		3 SABiosciences microRNAs that regulate IFNG:
		hsa-miR-29c hsa-miR-29a hsa-miR-29b

Clones:

Origene GFP tagged cDNA clones in CMV expression vector: IFNG Origene Myc/DDK tagged cDNA clones in CMV expression vector: IFNG Origene untagged cDNA clones in CMV expression vector: IFNG

Primers:		Origene genome-wide validated SYBR primer pairs: IFNG
		SABiosciences RT2 qPCR Primer Assay for IFNG: PPH00380A

REFSEQ mRNAs for IFNG gene: 

Additional cDNA sequence: 

highest scoring ESTs for IFNG:

Expression
for IFNG gene

IFNG expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IFNG

¹  / ²  / ³

5 probe-sets matching IFNG gene

Expression variation in blood from EXPOLDB for IFNG

Primers:		Origene genome-wide validated SYBR primer pairs: IFNG
		SABiosciences RT2 qPCR Primer Assay for IFNG: PPH00380A

Orthologs
for IFNG gene

Paralogs
for IFNG gene

Genomic Variants
for IFNG gene

Disorders & Mutations
for IFNG gene

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

10/2401 Novoseek disease relationships for IFNG gene (see all 2401 )

Medical News
for IFNG gene

• Genetic Markers Associated With Risk for Ulcerative Colitis Identified

Publications
for IFNG gene

• Homozygosis for (12) CA repeats in the first intron of the human IFN- gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. (PubMed id 15327519)^{1, 3, 4, 6} Dufour C.... Iolascon A. (2004)
• The effect of cytokine gene polymorphisms on pediatric heart allograft outcome. (PubMed id 11404167)^{3, 6, 7} Awad M.R....Zeevi A. (2001)
• Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region. (PubMed id 15858598)^{1, 3, 6} Koch O....Kwiatkowski D. (2005)
• Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL-10) in Down patients with coeliac disease. (PubMed id 16182624)^{1, 3, 6} Cataldo F....Corsello G. (2005)
• Interferon-gamma gene microsatellite polymorphisms in patients with biopsy-proven giant cell arteritis and isolated polymyalgia rheumatica. (PubMed id 15675129)^{1, 3, 6} Gonzalez-Gay M.A....Ollier W.E. (2004)
• Impact of interferon-gamma and interleukin-4 gene polymorphisms on development and progression of IgA nephropathy in Japanese patients. (PubMed id 12552499)^{1, 3, 6} Masutani K....Iida M. (2003)
• Allele frequencies of +874T --> A single nucleotide polymorphism at the first intron of IFN-gamma gene in Alzheimer's disease patients. (PubMed id 14661818)^{1, 3, 6} Scola L....Caruso C. (2003)
• IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis. (PubMed id 15674394)^{1, 3, 6} Kantarci O.H....Vandenbroeck K. (2005)
• Polymorphisms in the interferon-gamma gene at position +874 in patients with chronic hepatitis C treated with high-dose interferon-alpha and ribavirin. (PubMed id 16051377)^{1, 3, 6} Dai C.Y....Yu M.L. (2005)
• Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese. (PubMed id 15815688)^{1, 3, 6} Tso H.W....Lau Y.L. (2005)
• TNFalpha, IFNgamma and IL-10 gene polymorphisms in a sample of Sicilian patients with coeliac disease. (PubMed id 15979955)^{1, 3, 6} Lio D....Cataldo F. (2005)
• Promoter and intron-1 region polymorphisms in the IFNG gene in patients with hepatitis E. (PubMed id 15932627)^{1, 3, 6} Arora R....Bamezai R. (2005)
• Functional IFNG polymorphism in intron 1 in association with an increased risk to promote sporadic breast cancer. (PubMed id 15900487)^{1, 3, 6} Saha A....Bamezai R. (2005)
• A functional variant of IFNgamma gene is associated with coeliac disease. (PubMed id 15215891)^{1, 3, 6} Rueda B....Martin J. (2004)
• Allele frequencies of polymorphisms of TNFA, IL-6, IL-10 and IFNG in an Italian Caucasian population. (PubMed id 12047360)^{3, 6} Poli F....Sirchia G. (2002)
• Association of IFNG gene polymorphism with asthma in the Indian population. (PubMed id 12209087)^{3, 6} Nagarkatti R....Ghosh B. (2002)
• IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFN-gamma-activated genes: evidence of transactivational activity in IFNGR1. (PubMed id 16785527)^{1, 3} Ahmed C.M. and Johnson H.M. (2006)
• Analysis of an IFN-gamma gene (IFNG) polymorphism in multiple sclerosis in Europe: effect of population structure on association with disease. (PubMed id 10505747)^{1, 6} Goris A....Vandenbroeck K. (1999)
• "Host tissue damage" signal ATP impairs IL-12 and IFNgamma secretion in LPS stimulated whole human blood. (PubMed id 18521569)^{1, 3} Nalos M....McLean A.S. (2008)
• IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study. (PubMed id 18414898)^{1, 3} Pacheco A.G....Moraes M.O. (2008)
• A single nucleotide polymorphism (A --> G) in intron 3 of IFNgamma gene is associated with asthma. (PubMed id 18385742)^{1, 3} Kumar A. and Ghosh B. (2008)
• Interferon gamma (IFNgamma) & interleukin-4 (IL-4) gene variants & cytokine levels in pulmonary tuberculosis. (PubMed id 17159260)^{1, 3} Vidyarani M....Narayanan P.R. (2006)
• The balance between influenza- and RSV-specific CD4 T cells secreting IL-10 or IFNgamma in young and healthy-elderly subjects. (PubMed id 16098562)^{1, 3} Lee F.E....Mosmann T.R. (2005)
• Linkage disequilibrium analysis of chromosome 12q14-15 in multiple sclerosis: delineation of a 118-kb interval around interferon-gamma (IFNG) that is involved in male versus female differential susceptibility. (PubMed id 12486605)^{1, 3} Goris A....Vandenbroeck K. (2002)
• Iron chelators and hypoxia mimetics inhibit IFNgamma-mediated Jak-STAT signaling. (PubMed id 18787531)^{1, 3} Gira A.K....Swerlick R.A. (2009)
• ESAT6-induced IFNgamma and CXCL9 can differentiate severity of tuberculosis. (PubMed id 19340290)^{1, 3} Hasan Z....Hussain R. (2009)
• Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis . (PubMed id 19773677)^{1, 3} Nuolivirta K....Helminen M. (2009)
• IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis. (PubMed id 18793860)^{1, 3} Frisullo G....Batocchi A.P. (2008)
• Is IP-10 a better biomarker for active and latent tuberculosis in children than IFNgamma? (PubMed id 19065267)^{1, 3} Whittaker E....Kampmann B. (2008)
• Transcriptional activity of genes encoding interferon gamma (IFNgamma) and its receptor assessed in peripheral blood mononuclear cells in patients with cardiac syndrome X. (PubMed id 17546485)^{1, 3} Dabek J....Gasior Z. (2007)
• IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan. (PubMed id 17136124)^{1, 3} Salih M.A....Mohamed H.S. (2007)
• CpG methylation patterns in the IFNgamma promoter in naive T cells: variations during Th1 and Th2 differentiation and between atopics and non-atopics. (PubMed id 17121582)^{1, 3} White G.P....Holt P.G. (2006)
• An IFNG polymorphism is associated with interferon-beta response in Spanish MS patients. (PubMed id 16430971)^{1, 3} Martinez A....Arroyo R. (2006)
• The presence of IFNG 3/3 genotype in the recipient associates with increased risk for Epstein-Barr virus reactivation after allogeneic haematopoietic stem cell transplantation. (PubMed id 16409297)^{1, 3} Bogunia-Kubik K....Lange A. (2006)
• The pronounced Th17 profile in systemic sclerosis (SS c) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. (PubMed id 19536281)^{1, 3} Radstake T.R....Lafyatis R. (year=2009;month=;day=)
• Free iron ions decrease indoleamine 2,3-dioxygenase e xpression and reduce IFNgamma-induced inhibition of Chlamydia trachomatis infec tion. (PubMed id 19306922)^{1, 3} Krausse-Opatz B....KAPhler L. (2009)
• New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer. (PubMed id 18337305)^{1, 3} Guzman V.B....Morgun A. (2008)
• CpG methylation of the IFNG gene as a mechanism to induce immunosuppression [correction of immunosupression] in tumor-infiltrating lymphocytes. (PubMed id 18684979)^{1, 3} Janson P.C....Winqvist O. (2008)
• Acute lung transplant rejection is associated with localized increase in T-cell IFNgamma and TNFalpha proinflammatory cytokines in the airways. (PubMed id 18091521)^{1, 3} Hodge G....Holmes M. (2007)
• IFNG +874T/A polymorphism is not associated with American tegumentary leishmaniasis susceptibility but can influence Leishmania induced IFN-gamma production. (PubMed id 17456233)^{1, 3} Matos G.I....Da-Cruz A.M. (2007)
• The role of costimulatory molecules CD80 and CD86 and IFNgamma in the pathogenesis of ulcerative colitis. (PubMed id 15628695)^{1, 3} Scarpa M....D'Amico D.F. (2004)
• Analysis of an interferon-gamma gene (IFNG) polymorphism in Danish and Finnish insulin-dependent diabetes mellitus (IDDM) patients and control subjects. Danish Study Group of Diabetes in Childhood. (PubMed id 9058314)^{1, 6} Pociot F....Nerup J. (1997)
• Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer. (PubMed id 19959217)^{1, 3} Ivansson E.L....Gyllensten U.B. (year=2010;month=Mar;day=)
• IFNG (+874 T/A) polymorphism and cervical intraepithelial neoplasia in Brazilian women. (PubMed id 19232001)³ von Linsingen R....da GraAsa Bicalho M. (2009)
• Cohesins form chromosomal cis-interactions at the dev elopmentally regulated IFNG locus. (PubMed id 19458616)³ Hadjur S....Merkenschlager M. (2009)
• TNF, IFNG, IL6, IL10 and TGFB1 gene polymorphisms in South and Southeast Brazil. (PubMed id 18680515)³ Visentainer J.E....de Souza C.A. (2008)
• Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFNgamma response. (PubMed id 18514317)³ Parsa K.V....Tridandapani S. (2008)
• A synergistic role for IL-1beta and TNFalpha in monocyte-derived IFNgamma inducing activity. (PubMed id 18805021)³ Raices R.M....Wewers M.D. (2008)
• A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles. (PubMed id 16762155)³ Carlo-Stella N....Cuccia M. (2006)
• An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells. (PubMed id 16724074)³ Gonsky R....Targan S.R. (2006)
• JNK signaling involved in the effects of cyclic AMP on IL-1beta plus IFNgamma-induced inducible nitric oxide synthase expression in hepatocytes. (PubMed id 15115662)³ Zhang B....Harbrecht B.G. (2004)
• Mapping of the immune interferon gamma gene (IFNG) to chromosome band 12q14 by fluorescence in situ hybridization. (PubMed id 7587386)³ Zimonjic D.B....Popescu N.C. (1995)
• Notch activation enhances IFNgamma secretion by human peripheral blood and decidual NK cells. (PubMed id 20004979)³ Manaster I....Mandelboim O. (year=2010;month=Jan;day=)
• The role of IFNgamma nuclear localization sequence in intracellular function. (PubMed id 12799413)¹ Ahmed C.M....Johnson H.M. (2003)
• IFNalpha2b stimulated release of IFNgamma differentially regulates T cell and NK cell mediated tumor cell cytotoxicity. (PubMed id 17112599)¹ Bose A. and Baral R. (2007)
• Involvement of IFNbeta on IFNgamma and nitric oxide (NO) production by bone marrow (BM) cells in response to lipopolysaccharide. (PubMed id 16978828)¹ Campillo J.A....Subiza J.L. (2006)
• DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways. (PubMed id 15735741)¹ Xue L....Bjeldanes L.F. (2005)
• [Clinical implications of combined measurement bone m arrow T cells intracellular IFNgamma and HLA-DRB1*1501 measurement in predictin g the response to immunosuppressive therapy for aplastic anemia] (PubMed id 18218241)¹ Chen Y....Ge L.F. (2007)
• IFNgamma pretreatment sensitizes human choriocarcinoma cells to etoposide-induced apoptosis. (PubMed id 16467399)¹ Sun Q.H....Xia H.F. (2006)
• IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway. (PubMed id 11948413)¹ Fulda S. and Debatin K.M. (2002)
• Low T cell production of TNFalpha and IFNgamma in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism. (PubMed id 11114280)¹ Rudwaleit M....Braun J. (2001)
• Induction of apoptosis by IFNgamma in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit. (PubMed id 10453076)¹ Bernassola F....Melino G. (1999)
• Peripheral T lymphocyte cytokine profile (IFNgamma, IL-2, IL-4) and CD30 expression/release during measles infection. (PubMed id 10457402)¹ Vinante F....Pizzolo G. (1999)
• Serum IgE level is negatively correlated with the ability of peripheral mononuclear cells to produce interferon gamma (IFNgamma): evidence of reduced expression of IFNgamma mRNA in atopic patients. (PubMed id 9537784)¹ Teramoto T....Kondo N. (1998)
• Mutation screening of interferon-gamma (IFNgamma) as a candidate gene for asthma. (PubMed id 9433936)¹ Hayden C....Lesouef P. (1997)
• Intranasal IFNgamma extends passive IgA antibody prot ection of mice against Mycobacterium tuberculosis lung infection. (PubMed id 16487246)¹ Reljic R....Ivanyi J. (year=2006;month=Mar;day=)
• IFNgamma enhances IL-23 production during Francisella infection of human monocytes. (PubMed id 18319062)¹ Butchar J.P....Tridandapani S. (2008)
• Validation of a HLA-A2 tetramer flow cytometric method, IFNgamma real time RT-PCR, and IFNgamma ELISPOT for detection of immunologic response to gp100 and MelanA/MART-1 in melanoma patients. (PubMed id 18945350)¹ Xu Y....Richards S.M. (2008)
• Adult asthmatics display exaggerated IFNgamma responses to human metapneumovirus and respiratory syncytial virus. (PubMed id 17534407)¹ Douville R.N....HayGlass K.T. (2007)
• c-Myc partially mediates IFNgamma-induced apoptosis in the primary hepatocyte. (PubMed id 17504442)¹ McCullough C.T....Harrison D.J. (2007)
• Alloreaction increases or restores CD40, CD54, and/or HLA molecule expression in acute myelogenous leukemia blasts, through secretion of inflammatory cytokines: Dominant role for TNFbeta, in concert with IFNgamma. (PubMed id 16990783)¹ Eljaafari A....Thomas X. (2006)
• Opposing effect of IFNgamma and IFNalpha on expression of NKG2 receptors: negative regulation of IFNgamma on NK cells. (PubMed id 15829421)¹ Zhang C....Tian Z. (2005)
• Enhancing CTL responses to melanoma cell vaccines in vivo: synergistic increases obtained using IFNgamma primed and IFNbeta treated B7-1+ B16-F10 melanoma cells. (PubMed id 14636243)¹ Dezfouli S....Ralph S.J. (2003)
• IFNgamma production in peripheral blood of early Lyme disease patients to hLFAalphaL (aa326-345). (PubMed id 12385648)¹ Gomes-Solecki M.J....Dattwyler R.J. (2002)
• Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. (PubMed id 11713592)¹ Kirikoshi H....Katoh M. (2001)
• IL-2 enhances standard IFNgamma/LPS activation of macrophage cytotoxicity to human ovarian carcinoma in vitro: a potential for adoptive cellular immunotherapy. (PubMed id 10525372)¹ Han X....Raju K.S. (1999)
• Modulation of PECAM-1 (CD31) expression in human endothelial cells: effect of IFNgamma and IL-10. (PubMed id 10213905)¹ Bujan J....Alvarez-Mon M. (1999)
• Constitutive and IFNgamma-induced activation of MHC2T A promoter type III in human melanoma cell lines is governed by separate regula tory elements within the PIII upstream regulatory region. (PubMed id 17067677)¹ van der Stoep N....van den Elsen P.J. (year=2007;month=Mar;day=)
• Enhanced IFNgamma production in adenosine-treated CHO cells: a mechanistic study. (PubMed id 19507259)¹ Chong W.P....Yap M.G. (2009)
• Encephalitogenic T cells that stably express both T-b et and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 p rofiles. (PubMed id 19692128)¹ Abromson-Leeman S....Dorf M.E. (2009)
• Expression of purinergic receptors and modulation of P2X(7) function by the inflammatory cytokine IFNgamma in human epithelial cells. (PubMed id 19306841)¹ Welter-Stahl L....Coutinho-Silva R. (2009)
• Targeted therapy of renal cell carcinoma: synergistic activity of cG250-TNF and IFNg. (PubMed id 19384924)¹ Bauer S....Renner C. (2009)
• Prolonged exposure to IL-1beta and IFNgamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappaB/NO-dependent mechanism. (PubMed id 18246123)¹ Vercammen E....Beyaert R. (2008)
• Insights into gene modulation by therapeutic TNF and IFNgamma antibodies: TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome. (PubMed id 17928893)¹ Haider A.S....Krueger J.G. (2008)
• Enhanced effect of IFNgamma on the induced apoptosis of neuroblastoma cells by cytotoxic drugs. (PubMed id 18728974)¹ Tong H.X....Zhang J.H. (2008)
• The clinical grade maturation cocktail monophosphoryl lipid A plus IFNgamma generates monocyte-derived dendritic cells with the capacity to migrate and induce Th1 polarization. (PubMed id 17719152)¹ Ten Brinke A....van Ham S.M. (2007)
• STAT1-independent inhibition of cyclooxygenase-2 expression by IFNgamma; a common pathway of IFNgamma-mediated gene repression but not gene activation. (PubMed id 17016440)¹ Klampfer L....Augenlicht L. (2007)
• Dendritic cells modified with 6Ckine/IFNgamma fusion gene induce specific cytotoxic T lymphocytes in vitro. (PubMed id 17503043)¹ Xue G....Huang W. (2007)
• Multiplex cytokine detection versus ELISA for aqueous humor: IL-5, IL-10, and IFNgamma profiles in uveitis. (PubMed id 16384973)¹ Ooi K.G....Calder V.L. (2006)
• Targeted delivery of IFNgamma to tumor vessels uncouples antitumor from counterregulatory mechanisms. (PubMed id 15805293)¹ Curnis F....Corti A. (2005)
• Bcl-xL/Bax ratio is altered by IFNgamma in TNFalpha- but not in TRAIL-induced apoptosis in colon cancer cell line. (PubMed id 16085058)¹ Baillat G....Pommier G. (2005)
• Lack of STAT 1 phosphorylation at TYR 701 by IFNgamma correlates with disease outcome in melanoma patients. (PubMed id 16059651)¹ Boudny V....KovarA-k J. (2005)
• Effect of multiple doses of clarithromycin and amoxicillin on IL-6, IFNgamma and IL-10 plasma levels in patients with community acquired pneumonia. (PubMed id 15078004)¹ Demartini G....Scaglione F. (2004)
• IFNgamma sensitization to TRAIL-induced apoptosis in human thyroid carcinoma cells by upregulating Bak expression. (PubMed id 14647456)¹ Wang S.H....Baker J.R. (2004)
• LIGHT sensitizes IFNgamma-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members. (PubMed id 12767529)¹ Zhang M....Yang D. (2003)
• Differential and cooperative effects of TNFalpha, IL-1beta, and IFNgamma on human conjunctival epithelial cell receptor expression and chemokine release. (PubMed id 12714637)¹ Stahl J.L....Barney N.P. (2003)
• Identification and characterisation of a group of cervical carcinoma patients with profound downregulation of intratumoral Type 1 (IFNgamma) and Type 2 (IL-4) cytokine mRNA expression. (PubMed id 12628838)¹ Gey A....Tartour E. (2003)
• Nitric oxide attenuates beryllium-induced IFNgamma responses in chronic beryllium disease: evidence for mechanisms independent of IL-18. (PubMed id 12027422)¹ Barna B.P....Thomassen M.J. (2002)
• The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells. (PubMed id 11973642)¹ Sers C.... Schafer R. (2002)
• Oral terbutaline differentially affects cytokine (IL-10, IL-12, TNF, IFNg) release in multiple sclerosis patients and controls. (PubMed id 12417450)¹ Heesen C....Schulz K.H. (2002)

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