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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFNG Gene

protein-coding GIFtS: 68
GCID: GC12M068548

interferon, gamma

Explore 540 diseases affiliated with
IFNG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interferon, Gamma¹ ²
Immune Interferon² ³
IFN-Gamma¹
IFG² ⁵
IFI² ⁵
Interferon Gamma²

External Ids:	HGNC: 5438¹	Entrez Gene: 3458²	Ensembl: ENSG00000111537⁷	OMIM: 147570⁵	UniProtKB: P01579³

Export aliases for IFNG gene to outside databases

Previous GC identifers: GC12M068064 GC12M068352 GC12M068265 GC12M066834 GC12M065599

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNG:

This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral,

immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are

associated with aplastic anemia.(provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having

antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has

antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I

interferons

Gene Wiki entry for IFNG (Interferon-gamma)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFNG gene promoter:
ATF-2 CREB POU2F1 deltaCREB POU2F1b POU2F1a STAT3 POU2F1c Hlf Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFNG promoter sequence

Search SABiosciences Chromatin IP Primers for IFNG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q14

IFNG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNG gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M068548: view genomic region (about GC identifiers)

Start:	68,548,548 bp from pter	End:	68,553,527 bp from pter
Size:	4,980 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579 (See protein sequence)

Recommended Name: Interferon gamma precursor

Size: 166 amino acids; 19348 Da

Subunit: Homodimer

Subcellular location: Secreted

5 PDB 3D structures from and Proteopedia for IFNG:

1EKU (3D)

1FG9 (3D)

1FYH (3D)

1HIG (3D)

3BES (3D)

Secondary accessions: B5BU88 Q53ZV4

Explore the universe of human proteins at neXtProt for IFNG: NX_P01579

Post-translational modifications:

Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or

Gly-161¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01579

IFNG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000610.2

ENSEMBL proteins:

ENSP00000229135

Reactome Protein details: P01579
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant IFNG Protein
	R&D Systems Recombinant & Natural Proteins for IFNG (IFN-gamma)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IFNG OriGene Custom Protein Services for IFNG
	GenScript Purified and Recombinant Proteins for IFNG
	Novus Biologicals IFNG Proteins Novus Biologicals IFNG Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IFNG
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0009897	external side of plasma membrane	IEA	--

IFNG for ontologies About GeneDecksing

IFNG Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IFNG
	R&D Systems Antibodies for IFNG (IFN-gamma)
	Cell Signaling Technology (CST) Antibodies for IFNG
	OriGene Antibodies (see all 3): IFNG OriGene Custom Antibody Services for IFNG
	GenScript Custom Superior Antibodies Services for IFNG
	Novus Biologicals IFNG Antibodies
	Abcam antibodies for IFNG
	Browse Antibodies at Uscn
	ThermoFisher Antibody for IFNG

Assay Products for IFNG:

	EMD Millipore Kits and Assays for the Analysis of IFNG
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IFNG (IFN-gamma) (see all)
	GenScript Custom Assay Services for IFNG
	Enzo Life Sciences assays for IFNG
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFNG for domains About GeneDecksing

3 InterPro domains/families:

IPR012351 4_helix_cytokine_core

IPR009079 4_helix_cytokine-like_core

IPR002069 Interferon_gamma

Graphical View of Domain Structure for InterPro Entry P01579

ProtoNet protein and cluster: P01579

1 Blocks protein family: IPB002069 Interferon gamma

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Similarity: Belongs to the type II (or gamma) interferon family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having

antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has

antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I

interferons

Genatlas biochemistry entry for IFNG:

interferon type II,gamma,19.3kDa,expressed by lymphocytes,involved in immunoregulation

Summary:

IFNG as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Hematopoietic progenitor cells, Mature dendritic-like cells

miRNA Products:		OriGene 3'-UTR Clone: IFNG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNG
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNG (see all 9):
		hsa-miR-3671 hsa-miR-607 hsa-miR-340 hsa-miR-633 hsa-miR-656 hsa-miR-3622b-3p hsa-miR-3121-3p hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: IFNG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNG (see all 7) OriGene shRNA RFP: IFNG OriGene siRNA: IFNG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNG

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IFNG

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNG (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNG OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNG (NM_000619)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IFNG
		Search LifeMap BioReagents cell lines for IFNG

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNG

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005133	interferon-gamma receptor binding	IEA	--

IFNG for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IFNG:

Synthetic lethal with c-Myc af

Animal Models:
Mouse knock-outs for IFNG: Ifng^tm1Ts Ifng^tm1Yiw
15/23 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Ifng) (see all 23):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	liver/biliary system	mortality/aging	muscle

IFNG for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/58 super-pathways (see all 58) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Allograft rejection

Allograft rejection	1.00	THC Differentiation Pathway	0.39
Type I diabetes mellitus	0.67	Antigen processing and presentation	0.25
Graft-versus-host disease	0.63

Immune response_IFN gamma signaling pathway

	Immune response_IFN gamma signaling pathway	1.00			IFN-gamma pathway	0.43
	Immune response IFN gamma signaling pathway	1.00

Immune response IL-12-induced IFN-gamma production

	Immune response IL-12-induced IFN-gamma production	1.00			IL12-mediated signaling events	0.33
	Immune response_IL-12-induced IFN-gamma production	0.88

Toll Comparative Pathway

	Immune response MIF in innate immunity response	0.46			iNOS Signaling	0.34
	Immune response_MIF in innate immunity response	0.46

Transcription_Role of VDR in regulation of genes involved in osteoporosis

Transcription_Role of VDR in regulation of genes involved in osteoporosis

1.00

Transcription Role of VDR in regulation of genes involved in osteoporosis

0.80

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for IFNG (see all 8)

	Immune response IFN gamma signaling pathway
	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Immune response Role of integrins in NK cells cytotoxicity
	Immune response CD16 signaling in NK cells
	Immune response IL-12-induced IFN-gamma production

3 R&D Systems Pathways for IFNG

	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Th1 Differentiation
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNG (see all 12)

	THC Differentiation Pathway
	Cytokine Network
	MSP-RON Signaling
	HMGB1 Pathway
	Interferon Pathway

1 Cell Signaling Technology (CST) Pathway for IFNG

Jak/Stat Pathway

5/10 GeneGo (Thomson Reuters) Pathways for IFNG (see all 10)

	Immune response MIF-mediated glucocorticoid regulation
	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Immune response CD16 signaling in NK cells

5/20 BioSystems Pathways for IFNG (see all 20)

	Type II interferon signaling (IFNG)
	Senescence and Autophagy
	Cytokines and Inflammatory Response
	TGF Beta Signaling Pathway
	Selenium Pathway

5 Reactome Pathways for IFNG

	Interferon gamma signaling
	Regulation of IFNG signaling
	Cytokine Signaling in Immune system
	Interferon Signaling
	Immune System

5/23 Kegg Pathways (Kegg details for IFNG) (see all 23):

	Proteasome
	Cytokine-cytokine receptor interaction
	Regulation of autophagy
	TGF-beta signaling pathway
	Osteoclast differentiation

IFNG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IFNG

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/77 Interacting proteins for IFNG (P01579³ ENSP00000229135⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 77)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IFNGR2	P38484³, ENSP00000290219⁴	I2D: score=4 STRING: ENSP00000290219
IFNGR1	P15260³, ENSP00000356713⁴	I2D: score=5 STRING: ENSP00000356713
PDIA3	P30101³, ENSP00000300289⁴	I2D: score=2 STRING: ENSP00000300289
TNF	P01375³, ENSP00000398698⁴	I2D: score=2 STRING: ENSP00000398698
KPNA2	P52292³	I2D: score=1

About this table

Gene Ontology (GO): 5/64 biological process terms (GO ID links to tree view) (see all 64): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IDA	15604419
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0001781	neutrophil apoptotic process	IEA	--
GO:0002026	regulation of the force of heart contraction	IEA	--
GO:0002053	positive regulation of mesenchymal cell proliferation	ISS	--

IFNG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IFNG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNG
UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Pharmaceutical: Available under the name Actimmune (Genentech). Used for reducing the frequency and severity of serious

infections associated with chronic granulomatous disease (CGD)

1 HMDB Compound for IFNG About this table

Compound	Synonyms	CAS #	PubMed Ids
Simvastatin	(+)-Simvastatin (see all 28)	79902-63-9	--

2 DrugBank Compounds for IFNG About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glucosamine	--	3416-24-8	target	--	16431966 16155294 17238806 16709188
Olsalazine	--	15722-48-2	target	--	17034586 9797390

10/121 Novoseek chemical compound relationships for IFNG gene (see all 121) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	82.3	559	11970912 (6), 9527395 (6), 10792507 (5), 11172624 (5) (see all 99)
tuberculin	81.7	291	16126802 (4), 19732759 (4), 12491197 (3), 17682705 (3) (see all 99)
indoleamine	81.5	174	10729320 (4), 15070879 (3), 1398953 (2), 7523670 (2) (see all 99)
neopterin	80.5	442	1341444 (5), 10361231 (5), 1909303 (5), 17657857 (5) (see all 99)
il 10	79.5	249	12394188 (4), 8902857 (3), 11745683 (3), 19274101 (3) (see all 99)
ionomycin	75.5	228	9876227 (3), 15735428 (3), 16600192 (3), 1971531 (2) (see all 99)
il-12	70.7	91	11479428 (5), 18708162 (4), 15122806 (3), 15140777 (3) (see all 53)
nitric oxide	69.7	1599	11069732 (6), 10583599 (6), 1517576 (6), 9328118 (6) (see all 99)
alpha-galactosylceramide	69.2	42	12902477 (2), 15173890 (2), 15599405 (1), 15749842 (1) (see all 35)
kynurenine	68.1	101	1465184 (5), 8288893 (4), 18823288 (4), 1909303 (4) (see all 53)

Search CenterWatch for drugs/clinical trials and news about IFNG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNG gene:

NM_000619.2

Unigene Cluster for IFNG:

Interferon, gamma

Hs.856 [show with all ESTs]

Unigene Representative Sequence: BC070256

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000229135(uc001stw.1)

miRNA Products:		OriGene 3'-UTR Clone: IFNG Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNG
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNG (see all 9):
		hsa-miR-3671 hsa-miR-607 hsa-miR-340 hsa-miR-633 hsa-miR-656 hsa-miR-3622b-3p hsa-miR-3121-3p hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: IFNG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNG (see all 7) OriGene shRNA RFP: IFNG OriGene siRNA: IFNG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNG

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNG (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNG OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNG (NM_000619)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IFNG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNG

Additional cDNA sequence:

AB451324.1 AB451453.1 AF506749.1 AM903379.1 AY044154.1 AY255837.1 AY255839.1 BC070256.1

EF173872.1 V00543.1 X01992.1 X13274.1 X62468.1 X62469.1 X62470.1 X62471.1

X62472.1 X62473.1 X62474.1 X87308.1

3 DOTS entries:

DT.413894 DT.413893 DT.91824036

24/40 AceView cDNA sequences (see all 40):

BG230744 NM_000619 T29780 AA969504 AA381654 AA381839 V00543 X13274

CD639121 AA381626 CD640310 AF506749 AY255839 X01992 AA381733 AY044154

AA381667 CD638881 BC070256 AA381921 AY255837 CD520994 CD520458 X87308

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGTGCTT

About this image

IFNG expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

See IFNG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNG

SOURCE GeneReport for Unigene cluster: Hs.856

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Tissue specificity: Released primarily from activated T lymphocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including IFNG (see all 41):

Multiple Sclerosis in human mouse rat

Interferons & Receptors in human mouse rat

Wound Healing in human mouse rat

Lymphoma in human mouse rat

Inflammasomes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IFNG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNG

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFNG gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ifng^{1 , 5}	interferon gamma^{1, 5}	62.99(n)¹ 41.56(a)¹		10 (66.75 cM)⁵ 15978¹ NM_008337.3¹ NP_032363.1¹ 118441047⁵
chicken (Gallus gallus)	Aves	IFNG_CHICK⁶	Interferon gamma	32(a)	1 ↔ 1	1(36925485-36929634)

ENSEMBL Gene Tree for IFNG (if available)
TreeFam Gene Tree for IFNG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121913164^1,2	C,	untested	81530959(-)	`TACTAC/TTTCCA`	1	--	int¹		0	--	--	--	--
rs121913166^1,2	C,	untested	81531180(-)	`AGGCTC/GTCTGT`	1	--	int¹		0	--	--	--	--
rs2069736^1,2	C,	--	65598704(-)	`GTTTCA/TGCTTT`	1	--	ds500¹		5		NS NA	214
rs2069735^1,2	C	--	65598723(-)	`CATTAT/CGTATA`	1	--	ds500¹		4		NS NA	94
rs2069726^1,2	C,F,	--	65598870(-)	`CTATTT/CCCTCC`	1	--	ds500¹		4		NS WA	210
rs4394909^1,2	H	--	65598895(+)	`GGCTAG/AAAATA`	1	--	ds500¹		4		NS EA	410
rs115027181^1,2	C,F,	--	65598994(+)	`AGAAAG/AATAAT`	1	--	ds500¹		1		WA	118
rs2069725^1,2	C,F,H,	--	65599024(-)	`CTTTCG/ACTTTT`	1	--	ds500¹		13		NS EA WA	1276
rs35751061^1,2	C	--	65599093(+)	`AATTTC/TCACAG`	1	--	ds500¹		0	--	--	--	--
rs2069724^1,2	C,F,H,	--	65599153(-)	`TGAGAC/TCTGGA`	1	--	ds500¹		18		NS EA NA WA	1726

HapMap Linkage Disequilibrium report for IFNG (68548548 - 68553527 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFNG: --
Human Gene Mutation Database (HGMD): IFNG

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNG

DNA2.0 Custom Variant and Variant Library Synthesis for IFNG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IFNG for disorders           About GeneDecksing

OMIM gene information: 147570
OMIM disorders: 613254  609135  607948  609423  609532
UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA

is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in

bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an

endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which

would in turn be able to suppress hematopoiesis

20/540 diseases for IFNG (see all 540): About MalaCards

aplastic anemia chronic active epstein-barr virus infection african tick-bite fever vogt-koyanagi-harada disease

hyper-ige syndrome graft versus host disease tuberculosis, protection against hepatitis c virus, response to therapy of

anemia mhc class i deficiency alpha 1-antitrypsin deficiency eosinophilic pustular folliculitis

interferon gamma, receptor 1, deficiency spinal cord injury mycobacterium avium complex disease eastern equine encephalitis

relapsing-remitting multiple sclerosis rift valley fever churg-strauss syndrome natural killer cell leukemia

20/47 diseases from the University of Copenhagen DISEASES database for IFNG (see all 47):

Tuberculosis Hypersensitivity reaction type II disease Leishmaniasis Arthritis

Multiple sclerosis Asthma Dermatitis Inflammatory bowel disease

Melanoma Malaria Human immunodeficiency virus infectious disease Hypersensitivity reaction type I disease

Hepatitis Tetanus Leprosy Connective tissue disease

Pneumonia Influenza Vascular disease Eosinophilia

10/97 Novoseek disease relationships for IFNG gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	92.8	7943	2124085 (5), 18973545 (5), 8551280 (5), 12352046 (5) (see all 99)
tumors	86.1	8074	1717132 (6), 8425194 (6), 9621132 (6), 8402732 (6) (see all 99)
inflammation	81.3	562	17404615 (5), 19098321 (4), 9057354 (3), 10207939 (3) (see all 99)
tuberculosis	79.2	1312	16493060 (7), 10490990 (6), 14978096 (6), 16207403 (5) (see all 99)
autoimmune diseases	76.4	106	18775671 (4), 9883078 (3), 1746015 (2), 11037964 (2) (see all 80)
dermatitis atopic	74.5	286	11978138 (7), 9930598 (6), 7622767 (5), 8086777 (4) (see all 99)
tuberculosis active	73.6	54	19797760 (4), 15751711 (2), 19339489 (2), 12821809 (1) (see all 44)
multiple sclerosis	72	219	10404403 (4), 9626770 (4), 9310963 (3), 10694841 (3) (see all 99)
granulomatous disease chronic	70.9	91	1905138 (2), 1572085 (2), 8084323 (2), 1846940 (2) (see all 70)
virus infection	69.1	259	8070686 (4), 15999001 (3), 11983129 (3), 9649578 (2) (see all 99)

Genetic Association Database (GAD): IFNG
Human Genome Epidemiology (HuGE) Navigator: IFNG (543 documents)

Export disorders for IFNG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFNG gene, integrated from 9 sources (see all 9165):
(articles sorted by number of sources associating them with IFNG)

Utopia: connect your pdf to the dynamic
world of online information

Homozygosis for (12) CA repeats in the first intron of the human IFN- gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. (PubMed id 15327519)^{1, 2, 4, 9} Dufour C.... Iolascon A. (2004)
Association of polymorphisms in the human interferon-gamma and interleukin-10 gene with acute and chronic kidney transplant outcome: the cytokine effect on transplantation. (PubMed id 11292301)^{1, 4, 9} Asderakis A....Hutchinson I.V. (2001)
Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation. (PubMed id 12727483)^{1, 4, 9} Holweg C.T....Baan C.C. (2003)
Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL-10) in Down patients with coeliac disease. (PubMed id 16182624)^{1, 4, 9} Cataldo F....Corsello G. (2005)
Polymorphism of cytokine genes (TGF-beta1, IFN-gamma, IL-6, IL-10, and TNF-alpha) in patients with chronic pancreatitis. (PubMed id 15841043)^{1, 4, 9} Bendicho M.T....Lemaire D.C. (2005)
Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region. (PubMed id 15858598)^{1, 4, 9} Koch O....Kwiatkowski D. (2005)
[Polymorphism of TNF-alpha (308 A/G), IL-10 (1082 A/G, 819 C/T 592 A/C), IL-6 (174 G/C), and IFN-gamma (874 A/T); genetically conditioned cytokine synthesis level in children with diabetes type 1] (PubMed id 12818128)^{1, 4, 9} Siekiera U....Koehler B. (2002)
Interleukin-10, interleukin-6 and interferon-gamma gene polymorphisms in melanoma patients. (PubMed id 12394188)^{1, 4, 9} Martinez-Escribano J.A....Alvarez-Lopez M.R. (2002)
Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation. (PubMed id 12451269)^{1, 4, 9} Lu K.C....Mohanakumar T. (2002)
TNF-alpha, IL-6, IFN-gamma, and IL-10 gene expression polymorphisms and the IL-4 receptor alpha-chain variant Q576R: effects on renal allograft outcome. (PubMed id 11544427)^{1, 4, 9} Hahn A.B....Conti D.J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3458	HGNC: 5438	AceView: IFNG	Ensembl:ENSG00000111537	euGenes: HUgn3458
ECgene: IFNG	Kegg: 3458	H-InvDB: IFNG

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFNG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IFNG	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/IFNG
Wikipedia	http://en.wikipedia.org/wiki/Interferon_gamma
SeattleSNPs	http://pga.gs.washington.edu/data/ifng/

Intellectual Property for IFNG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IFNG gene:
Search GeneIP for patents involving IFNG

Licensable Technologies for IFNG gene:

Weizmann Institute:

Anti-inflammatory properties of low levels of IFN-g

(see all 2)

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section

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interferon, gamma

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