External Ids for IFNG Gene
Previous GeneCards Identifiers for IFNG Gene
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of the both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial inflections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Sep 2015]
GeneCards Summary for IFNG Gene
IFNG (Interferon, Gamma) is a Protein Coding gene. Diseases associated with IFNG include aplastic anemia, ifng-related and tsc2 angiomyolipomas, renal, modifier of. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include cytokine activity and interferon-gamma receptor binding.
UniProtKB/Swiss-Prot for IFNG Gene
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons