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IFNG Gene(Protein Coding)

Interferon Gamma

GCID:
GC12M068064
GIFtS:
57
Genes Participants
UDN Logo

Aliases for IFNG Gene

Aliases for IFNG Gene

  • Interferon Gamma 2 3 5
  • Immune Interferon 3 4
  • IFN-Gamma 3 4
  • IFG 3
  • IFI 3

External Ids for IFNG Gene

Previous GeneCards Identifiers for IFNG Gene

  • GC12M068352
  • GC12M068265
  • GC12M066834
  • GC12M068548
  • GC12M065599

Summaries for IFNG Gene

Entrez Gene Summary for IFNG Gene

  • This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

GeneCards Summary for IFNG Gene

IFNG (Interferon Gamma) is a Protein Coding gene. Diseases associated with IFNG include Tuberous Sclerosis 2 and Hepatitis C Virus. Among its related pathways are Bacterial infections in CF airways and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and interferon-gamma receptor binding.

UniProtKB/Swiss-Prot for IFNG Gene

  • Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Gene Wiki entry for IFNG Gene

Additional gene information for IFNG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNG Gene

Genomics for IFNG Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IFNG Gene

Promoters and enhancers for IFNG Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12I068158 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 +0.1 118 1.5 CTCF EBF1 DPF2 ZNF217 IKZF1 ATF7 RUNX3 IKZF2 GC12M068160 GC12M068159 IFNG GC12P068143 IFNG-AS1
GH12I068159 Enhancer 0.5 ENCODE 550.8 +1.1 1111 0.2 CTCF ZNF654 REST RAD21 GC12M068159 GC12M068160 IFNG GC12P068143 IFNG-AS1
GH12I068480 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -322.9 -322862 3.4 PKNOX1 ATF1 BMI1 BATF IRF4 ETV6 ATF7 IKZF2 RUNX3 CBFB LINC02384 IFNG NUP107 ENSG00000256917 PSMC6P2
GH12I067988 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +168.9 168918 4.8 PKNOX1 FOXA2 EBF1 BATF RELA GATA3 POLR2A ATF7 IKZF2 RUNX3 IFNG-AS1 LINC01479 IFNG IL22 DYRK2 GC12P067986 RPL39P28
GH12I068080 Enhancer 0.4 ENCODE 11.6 +78.9 78940 0.7 IKZF1 RUNX3 IFNG IFNG-AS1 GC12P068096 HNRNPA1P70
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFNG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNG gene promoter:

Genomic Locations for IFNG Gene

Genomic Locations for IFNG Gene
chr12:68,154,768-68,159,747
(GRCh38/hg38)
Size:
4,980 bases
Orientation:
Minus strand
chr12:68,548,548-68,553,527
(GRCh37/hg19)

Genomic View for IFNG Gene

Genes around IFNG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNG Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IFNG Gene

Proteins for IFNG Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IFNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01579-IFNG_HUMAN
    Recommended name:
    Interferon gamma
    Protein Accession:
    P01579
    Secondary Accessions:
    • B5BU88
    • Q53ZV4

    Protein attributes for IFNG Gene

    Size:
    166 amino acids
    Molecular mass:
    19348 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IFNG Gene

neXtProt entry for IFNG Gene

Protein Expression for IFNG Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IFNG Gene

  • Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • Glycosylation at posLast=4848 and isoforms=120

Other Protein References for IFNG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IFNG (IFNG)

Assay Products

No data available for DME Specific Peptides for IFNG Gene

Domains & Families for IFNG Gene

Gene Families for IFNG Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IFNG Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IFNG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01579

UniProtKB/Swiss-Prot:

IFNG_HUMAN :
  • Belongs to the type II (or gamma) interferon family.
Family:
  • Belongs to the type II (or gamma) interferon family.
genes like me logo Genes that share domains with IFNG: view

Function for IFNG Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IFNG Gene

GENATLAS Biochemistry:
interferon type II,gamma,19.3kDa,expressed by lymphocytes,involved in immunoregulation
UniProtKB/Swiss-Prot Function:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

LifeMap Function Summary for IFNG Gene

IFNG as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for IFNG Gene

Gene Ontology (GO) - Molecular Function for IFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005133 interferon-gamma receptor binding TAS,IEA --
GO:0005515 protein binding IPI 7617032
genes like me logo Genes that share ontologies with IFNG: view
genes like me logo Genes that share phenotypes with IFNG: view

Animal Models for IFNG Gene

MGI Knock Outs for IFNG:

Animal Model Products

Clone Products

  • Addgene plasmids for IFNG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNG Gene

Localization for IFNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNG gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for IFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA --
GO:0005615 extracellular space IBA --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with IFNG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNG Gene

Pathways & Interactions for IFNG Gene

genes like me logo Genes that share pathways with IFNG: view

SIGNOR curated interactions for IFNG Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for IFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 15604419
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001934 positive regulation of protein phosphorylation IDA 22504299
GO:0002250 adaptive immune response IBA --
GO:0006915 apoptotic process IGI 7828849
genes like me logo Genes that share ontologies with IFNG: view

Drugs & Compounds for IFNG Gene

Products:

  1. Drug

(74) Drugs for IFNG Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olsalazine Approved Pharma Target 1
Apremilast Approved, Investigational Pharma Target 81
Glucosamine Approved, Investigational Nutra Target 211
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 537
Fontolizumab Investigational Pharma Target, antibody 0

(53) Additional Compounds for IFNG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNG: view

Transcripts for IFNG Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IFNG Gene

(1) REFSEQ mRNAs :
(20) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNG Gene

Interferon, gamma:
Representative Sequences:

Clone Products

  • Addgene plasmids for IFNG

Alternative Splicing Database (ASD) splice patterns (SP) for IFNG Gene

No ASD Table

Relevant External Links for IFNG Gene

GeneLoc Exon Structure for
IFNG
ECgene alternative splicing isoforms for
IFNG

Expression for IFNG Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNG Gene

mRNA expression in normal human tissues for IFNG Gene
mRNA expression by GTEx for IFNG GenemRNA expression by BioGPS for IFNG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFNG Gene

This gene is overexpressed in Whole Blood (x29.9).

Protein differential expression in normal tissues from HIPED for IFNG Gene

This gene is overexpressed in Testis (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFNG Gene



Protein tissue co-expression partners for IFNG Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNG Gene:

IFNG

SOURCE GeneReport for Unigene cluster for IFNG Gene:

Hs.856

mRNA Expression by UniProt/SwissProt for IFNG Gene:

P01579-IFNG_HUMAN
Tissue specificity: Released primarily from activated T lymphocytes.

Evidence on tissue expression from TISSUES for IFNG Gene

  • Blood(4.8)
  • Lymph node(3.2)
  • Spleen(3.1)
  • Intestine(2.8)
  • Lung(2.8)
  • Skin(2.8)
  • Bone marrow(2.7)
  • Liver(2.7)
  • Nervous system(2.7)
  • Heart(2.6)
  • Kidney(2.4)
  • Pancreas(2.2)
  • Eye(2.1)
  • Muscle(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNG Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • lymphatic
  • respiratory
Organs:
Thorax:
  • lung
General:
  • blood
  • bone marrow
  • hair
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with IFNG: view

Orthologs for IFNG Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IFNG 33 34
  • 99.2 (n)
dog
(Canis familiaris)
 Mammalia IFNG 33
  • 77.71 (n)
IFN-GAMMA 34
  • 66 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia IFNG 33 34
  • 75.35 (n)
mouse
(Mus musculus)
 Mammalia Ifng 33 16 34
  • 62.99 (n)
rat
(Rattus norvegicus)
 Mammalia Ifng 33
  • 60.65 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia IFNG 34
  • 32 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves IFN-GAMMA 34
  • 33 (a)
 OneToOne
Species where no ortholog for IFNG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNG Gene

ENSEMBL:
Gene Tree for IFNG (if available)
TreeFam:
Gene Tree for IFNG (if available)

Paralogs for IFNG Gene

No data available for Paralogs for IFNG Gene

Variants for IFNG Gene

Sequence variations from dbSNP and Humsavar for IFNG Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs137854903 not-provided, uncertain-significance, not provided, Aplastic anemia 68,155,253(-) TTGATTGAT/TTGAT 3_prime_UTR_variant
rs181407537 uncertain-significance, Aplastic anemia 68,159,620(-) T/C 5_prime_UTR_variant
rs200610212 uncertain-significance, Aplastic anemia 68,159,491(-) G/A/T intron_variant
rs2069707 drug-response, Hepatitis C virus infection, response to therapy of 68,160,508(-) G/C upstream_transcript_variant
rs2069722 likely-benign, Aplastic anemia 68,155,173(-) G/A/T 3_prime_UTR_variant

Variation tolerance for IFNG Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNG Gene

Human Gene Mutation Database (HGMD)
IFNG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IFNG Gene

Disorders for IFNG Gene

MalaCards: The human disease database

(247) MalaCards diseases for IFNG Gene - From: HGMD, OMIM, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tuberous sclerosis 2
  • ts
hepatitis c virus
  • hepatitis c virus, susceptibility to
aplastic anemia
  • aplastic anemia, susceptibility to
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
cutaneous leishmaniasis
  • asian desert cutaneous leishmaniasis
- elite association - COSMIC cancer census association via MalaCards
Search IFNG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IFNG_HUMAN
  • Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. {ECO:0000269 PubMed:15327519}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Additional Disease Information for IFNG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFNG: view

No data available for Genatlas for IFNG Gene

Publications for IFNG Gene

  1. Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart. (PMID: 20388088) Licastro F … Ferrari R (Current pharmaceutical design 2010) 3 22 44 58
  2. Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases. (PMID: 19117745) Vasakova M … Striz I (Respiratory medicine 2009) 3 22 44 58
  3. Cytokine gene polymorphisms across tuberculosis clinical spectrum in Pakistani patients. (PMID: 19274101) Ansari A … Hussain R (PloS one 2009) 3 22 44 58
  4. Effect of desensitization in solid organ transplant recipients depends on some cytokines genes polymorphism. (PMID: 19332120) Lobashevsky AL … Turrentine MW (Transplant immunology 2009) 3 22 44 58
  5. Genetic variants in immunoregulatory genes and risk for childhood lymphomas. (PMID: 19508433) Andrie E … Petridou ET (European journal of haematology 2009) 3 22 44 58

Products for IFNG Gene

  • Addgene plasmids for IFNG

Sources for IFNG Gene

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