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IFNG Gene

protein-coding   GIFtS: 69
GCID: GC12M068548

Interferon, Gamma

  See IFNG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Gamma1 2
Immune Interferon2 3
IFN-gamma2 3
IFG2 5
IFI2 5
Interferon Gamma2

External Ids:    HGNC: 54381   Entrez Gene: 34582   Ensembl: ENSG000001115377   OMIM: 1475705   UniProtKB: P015793   

Export aliases for IFNG gene to outside databases

Previous GC identifers: GC12M068064 GC12M068352 GC12M068265 GC12M066834 GC12M065599


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFNG Gene:
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with
antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this
gene are associated with aplastic anemia.(provided by RefSeq, Nov 2009)

GeneCards Summary for IFNG Gene:
IFNG (interferon, gamma) is a protein-coding gene. Diseases associated with IFNG include leishmaniasis, and tuberculous uveitis. GO annotations related to this gene include interferon-gamma receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579
Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having
antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has
antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the
type I interferons

Gene Wiki entry for IFNG (Interferon-gamma) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFNG gene promoter:
         ATF-2   CREB   POU2F1   deltaCREB   POU2F1b   POU2F1a   STAT3   POU2F1c   Hlf   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNG promoter sequence
   Search Chromatin IP Primers for IFNG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q14

IFNG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNG gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M068548:  view genomic region     (about GC identifiers)

Start:
68,548,548 bp from pter      End:
68,553,527 bp from pter
Size:
4,980 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579 (See protein sequence)
Recommended Name: Interferon gamma precursor  
Size: 166 amino acids; 19348 Da
Subunit: Homodimer
5 PDB 3D structures from and Proteopedia for IFNG:
1EKU (3D)        1FG9 (3D)        1FYH (3D)        1HIG (3D)        3BES (3D)    
Secondary accessions: B5BU88 Q53ZV4

Explore the universe of human proteins at neXtProt for IFNG: NX_P01579

Explore proteomics data for IFNG at MOPED

Post-translational modifications: 

  • Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157
    or Gly-1611
  • Glycosylation2 at Asn48, Asn120
  • Modification sites at PhosphoSitePlus

  • See IFNG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000610.2  
    ENSEMBL proteins: 
     ENSP00000229135  
    Reactome Protein details: P01579

    IFNG Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IFNG Protein
    R&D Systems Recombinant & Natural Proteins for IFNG (IFN-gamma)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IFNG
    OriGene Protein Over-expression Lysate for IFNG
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IFNG
    GenScript Purified and Recombinant Proteins for IFNG
    Novus Biologicals IFNG Proteins
    Novus Biologicals IFNG Lysates
    Sino Biological Recombinant Protein for IFNG
    Sino Biological Cell Lysate for IFNG
    ProSpec Recombinant Protein for IFNG
    Browse Proteins at Cloud-Clone Corp.

     
    eBioscience Proteins for IFNG: (see all 4
                        Human IFN gamma Recombinant Protein Carrier-Free 100 ug

     
    antibodies-online proteins for IFNG (179 products) 

     
    Search antibodies-online for peptides for IFNG

    IFNG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IFNG
    R&D Systems Antibodies for IFNG (IFN-gamma)
    Cell Signaling Technology (CST) Antibodies for IFNG 
    OriGene Antibodies for IFNG
    OriGene Custom Antibody Services for IFNG
    Novus Biologicals IFNG Antibodies
    Abcam antibodies for IFNG
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for IFNG
    antibodies-online antibodies for IFNG (638 products) 

    IFNG Assay Products:

    EMD Millipore Kits and Assays for the Analysis of IFNG
    OriGene Custom Assay Services for IFNG
    R&D Systems Flow Cytometry Kits for IFNG (IFN-gamma)         (see all)
    GenScript Custom Assay Services for IFNG
    Enzo Life Sciences assays for IFNG
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for IFNG: (see all 5
                        Human IFN-gamma Platinum ELISA 10 x 96 tests
    antibodies-online kits for IFNG (279 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFN: Interferons

    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR002069 Interferon_gamma

    Graphical View of Domain Structure for InterPro Entry P01579

    ProtoNet protein and cluster: P01579

    1 Blocks protein domain: IPB002069 Interferon gamma

    UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579
    Similarity: Belongs to the type II (or gamma) interferon family


    Find genes that share domains with IFNG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFNG_HUMAN, P01579
    Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having
    antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has
    antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the
    type I interferons

         Genatlas biochemistry entry for IFNG:
    interferon type II,gamma,19.3kDa,expressed by lymphocytes,involved in immunoregulation

         Summary: 
    IFNG as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Blood: Mature dendritic-like cells, Hematopoietic progenitor cells       to see all 2 cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IBA--
    GO:0005133interferon-gamma receptor binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IFNG           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IFNG:
     Synthetic lethal with c-Myc af 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ifng) (see all 24):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with IFNG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IFNG: Ifngtm1Ts Ifngtm1Yiw

       genOway: Develop your customized and physiologically relevant rodent model for IFNG

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFNG:
    hsa-mir-26b-5p (MIRT029122), hsa-mir-15a-5p (MIRT006913), hsa-mir-16-5p (MIRT006912), hsa-mir-409-3p (MIRT007285), hsa-mir-29b-3p (MIRT007034), hsa-mir-15b-5p (MIRT006914)

    Block miRNA regulation of human, mouse, rat IFNG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IFNG (see all 9):
    hsa-miR-3671 hsa-miR-607 hsa-miR-340 hsa-miR-633 hsa-miR-656 hsa-miR-3622b-3p hsa-miR-3121-3p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidIFNG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFNG
    Predesigned siRNA for gene silencing in human, mouse, rat IFNG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFNG

    Clone
    Products:
         
    OriGene clones in human, mouse for IFNG (see all 6)
    OriGene ORF clones in mouse, rat for IFNG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNG (NM_000619)
    Sino Biological Human cDNA Clone for IFNG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNG
    Addgene plasmids for IFNG 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IFNG
    Browse ESI BIO Cell Lines and PureStem Progenitors for IFNG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNG

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11635 VA6-13121 VF6-14270) for IFNG 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFNG_HUMAN, P01579: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IBA--
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with IFNG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFNG About   (see all 60)  
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.86
    Graft-versus-host disease0.65
    Allograft Rejection0.86
    THC Differentiation Pathway0.38
    Type I diabetes mellitus0.69
    Antigen processing and presentation0.36
    2CDK-mediated phosphorylation and removal of Cdc6
    Proteasome0.79
    Proteasome Degradation0.57
    3Toll Comparative Pathway
    Immune response MIF in innate immunity response0.46
    iNOS Signaling0.34
    4Immune response IFN gamma signaling pathway
    IFN-gamma pathway0.43
    Immune response IFN gamma signaling pathway0.43
    5Th1 Differentiation
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38


    Find genes that share SuperPaths with IFNG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for IFNG
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IFNG (see all 12)
        THC Differentiation Pathway
    Cytokine Network
    MSP-RON Signaling
    HMGB1 Pathway
    Interferon Pathway

    1 Cell Signaling Technology (CST) Pathway for IFNG
        Jak/Stat Pathway

    Selected GeneGo (Thomson Reuters) Pathways for IFNG (see all 10)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    Immune response CD16 signaling in NK cells

    Selected BioSystems Pathways for IFNG (see all 23)
        Cytokines and Inflammatory Response
    TGF Beta Signaling Pathway
    Senescence and Autophagy
    Type II interferon signaling (IFNG)
    Spinal Cord Injury


    2 Reactome Pathways for IFNG
        Interferon gamma signaling
    Regulation of IFNG signaling


    Selected Kegg Pathways  (Kegg details for IFNG) (see all 28):
        Proteasome
    Cytokine-cytokine receptor interaction
    HIF-1 signaling pathway
    Regulation of autophagy
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNG (see all 41): 
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IFNG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFNG (P015793 ENSP000002291354) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFP013753, ENSP000003986984I2D: score=2 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=2 
    ENSG00000206439P013753I2D: score=2 
    ENSG00000223952P013753I2D: score=2 
    ENSG00000228321P013753I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 66):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IDA15604419
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001781neutrophil apoptotic process IEA--
    GO:0002026regulation of the force of heart contraction IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation ISS--

    Find genes that share ontologies with IFNG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFNG

    UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579
    Pharmaceutical: Available under the name Actimmune (Genentech). Used for reducing the frequency and severity of
    serious infections associated with chronic granulomatous disease (CGD)

    1 HMDB Compound for IFNG    About this table
    CompoundSynonyms CAS #PubMed Ids
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    2 DrugBank Compounds for IFNG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glucosamine-- 3416-24-8target--16431966 16155294 17238806 16709188
    Olsalazine-- 15722-48-2target--17034586 9797390

    Selected Novoseek inferred chemical compound relationships for IFNG gene (see all 121)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 82.3 559 11970912 (6), 9527395 (6), 10792507 (5), 11172624 (5) (see all 99)
    tuberculin 81.7 291 16126802 (4), 19732759 (4), 12491197 (3), 17682705 (3) (see all 99)
    indoleamine 81.5 174 10729320 (4), 15070879 (3), 1398953 (2), 7523670 (2) (see all 99)
    neopterin 80.5 442 1341444 (5), 10361231 (5), 1909303 (5), 17657857 (5) (see all 99)
    il 10 79.5 249 12394188 (4), 8902857 (3), 11745683 (3), 19274101 (3) (see all 99)
    ionomycin 75.5 228 9876227 (3), 15735428 (3), 16600192 (3), 1971531 (2) (see all 99)
    il-12 70.7 91 11479428 (5), 18708162 (4), 15122806 (3), 15140777 (3) (see all 53)
    nitric oxide 69.7 1599 11069732 (6), 10583599 (6), 1517576 (6), 9328118 (6) (see all 99)
    alpha-galactosylceramide 69.2 42 12902477 (2), 15173890 (2), 15599405 (1), 15749842 (1) (see all 35)
    kynurenine 68.1 101 1465184 (5), 8288893 (4), 18823288 (4), 1909303 (4) (see all 53)



    Find genes that share compounds with IFNG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFNG gene: 
    NM_000619.2  

    Unigene Cluster for IFNG:

    Interferon, gamma
    Hs.856  [show with all ESTs]
    Unigene Representative Sequence: BC070256
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000229135(uc001stw.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat IFNG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IFNG (see all 9):
    hsa-miR-3671 hsa-miR-607 hsa-miR-340 hsa-miR-633 hsa-miR-656 hsa-miR-3622b-3p hsa-miR-3121-3p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidIFNG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFNG
    Predesigned siRNA for gene silencing in human, mouse, rat IFNG
    Clone
    Products:
         
    OriGene clones in human, mouse for IFNG (see all 6)
    OriGene ORF clones in mouse, rat for IFNG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNG (NM_000619)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNG
    Addgene plasmids for IFNG 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IFNG
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFNG
      QuantiTect SYBR Green Assays in human, mouse, rat IFNG
      QuantiFast Probe-based Assays in human, mouse, rat IFNG
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11635 VA6-13121 VF6-14270) for IFNG 

    Additional mRNA sequence: 

    AB451324.1 AB451453.1 AF506749.1 AM903379.1 AY044154.1 AY255837.1 AY255839.1 BC070256.1 
    EF173872.1 V00543.1 X01992.1 X13274.1 X62468.1 X62469.1 X62470.1 X62471.1 
    X62472.1 X62473.1 X62474.1 X87308.1 

    3 DOTS entries:

    DT.413894  DT.413893  DT.91824036 

    Selected AceView cDNA sequences (see all 40):

    X13274 BG230744 V00543 AA381839 AA969504 T29780 AA381654 NM_000619 
    CD520994 AA381667 AY255839 AY044154 X01992 CD639121 X87308 BC070256 
    AA381733 CD640310 CD638881 AY255837 CD520458 AA381626 AF506749 AA381921 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IFNG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGTGCTT
    IFNG Expression
    About this image


    IFNG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells
    IFNG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFNG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.856

    UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579
    Tissue specificity: Released primarily from activated T lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNG (see all 41): 
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFNG
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFNG
    QuantiTect SYBR Green Assays in human, mouse, rat IFNG
    QuantiFast Probe-based Assays in human, mouse, rat IFNG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for IFNG gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifng1 , 5 interferon gamma1, 5 62.99(n)1
    41.56(a)1
      10 (66.75 cM)5
    159781  NM_008337.31  NP_032363.11 
     1184410475 
    chicken
    (Gallus gallus)
    Aves IFN-GAMMA6
    Gallus gallus interferon, gamma (IFNG), mRNA.
    33(a)
    1 ↔ 1
    1(35013708-35017857)


    ENSEMBL Gene Tree for IFNG (if available)
    TreeFam Gene Tree for IFNG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFNG (see all 211)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219131661,2
    Cuntested168388602(-) AGGCTC/GTCTGT 1 -- int10--------
    rs1219131641,2
    Cuntested168388823(-) TACTAC/TTTCCA 1 -- int10--------
    rs2009365241,2
    C--65605834(+) CATTTC/TTTTTT 1 -- us2k10--------
    rs20697361,2
    C,F--68385334(-) GTTTCA/TGCTTT 1 -- ds50015Minor allele frequency- T:0.01NS NA 214
    rs20697351,2
    C--68385353(-) CATTAT/CGTATA 1 -- ds50014Minor allele frequency- C:0.01NS NA 94
    rs20697271,2
    C,F,A,H--68385491(-) CCTTCA/GTTTCA 1 -- ds500127Minor allele frequency- G:0.25NS NA EA WA 3118
    rs20697261,2
    C,F--68385500(-) CTATTT/CCCTCC 1 -- ds50014Minor allele frequency- C:0.04NS WA 210
    rs43949091,2
    H--68385525(+) GGCTAG/AAAATA 1 -- ds50014Minor allele frequency- A:0.00NS EA 410
    rs1891944081,2
    --68385612(+) AATCTA/GTATCT 1 -- ds50010--------
    rs1150271811,2
    C,F--68385624(+) AGAAAG/AATAAT 1 -- ds50011Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for IFNG (68548548 - 68553527 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IFNG: --
    Human Gene Mutation Database (HGMD): IFNG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNG
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147570   
    OMIM disorders: 613254  609135  607948  609423  609532  
    UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579
  • Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate
    numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia.
    Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry

  • Selected diseases for IFNG (see all 128):    
    About MalaCards
    leishmaniasis    tuberculous uveitis    aplastic anemia    eosinophilic pustular folliculitis
    fusariosis    aids, rapid progression to    mucocutaneous leishmaniasis    hepatitis c virus, response to therapy of
    autoimmune progesterone dermatitis    tsc2 angiomyolipomas, renal, modifier of    trichosporonosis    tuberculosis, protection against
    aplastic anemia, ifng-related    gestational choriocarcinoma    graft versus host disease    acute graft versus host disease
    neurosarcoidosis    pleural tuberculosis    tinea unguium    acute retinal necrosis syndrome

    5 diseases from the University of Copenhagen DISEASES database for IFNG:
    Aspergillosis     Fusariosis     Candidiasis     Tuberculosis
    Trichosporonosis

    Find genes that share disorders with IFNG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IFNG gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 92.8 7943 2124085 (5), 18973545 (5), 8551280 (5), 12352046 (5) (see all 99)
    tumors 86.1 8074 1717132 (6), 8425194 (6), 9621132 (6), 8402732 (6) (see all 99)
    inflammation 81.3 562 17404615 (5), 19098321 (4), 9057354 (3), 10207939 (3) (see all 99)
    tuberculosis 79.2 1312 16493060 (7), 10490990 (6), 14978096 (6), 16207403 (5) (see all 99)
    autoimmune diseases 76.4 106 18775671 (4), 9883078 (3), 1746015 (2), 11037964 (2) (see all 80)
    dermatitis atopic 74.5 286 11978138 (7), 9930598 (6), 7622767 (5), 8086777 (4) (see all 99)
    tuberculosis active 73.6 54 19797760 (4), 15751711 (2), 19339489 (2), 12821809 (1) (see all 44)
    multiple sclerosis 72 219 10404403 (4), 9626770 (4), 9310963 (3), 10694841 (3) (see all 99)
    granulomatous disease chronic 70.9 91 1905138 (2), 1572085 (2), 8084323 (2), 1846940 (2) (see all 70)
    virus infection 69.1 259 8070686 (4), 15999001 (3), 11983129 (3), 9649578 (2) (see all 99)

    Genetic Association Database (GAD): IFNG
    Human Genome Epidemiology (HuGE) Navigator: IFNG (543 documents)

    Export disorders for IFNG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFNG gene, integrated from 10 sources (see all 9272):
    (articles sorted by number of sources associating them with IFNG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Homozygosis for (12) CA repeats in the first intron of the human IFN- gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. (PubMed id 15327519)1, 2, 4, 9 Dufour C.... Iolascon A. (Br. J. Haematol. 2004)
    2. Association of polymorphisms in the human interferon-gamma and interleukin-10 gene with acute and chronic kidney transplant outcome: the cytokine effect on transplantation. (PubMed id 11292301)1, 4, 9 Asderakis A....Hutchinson I.V. (Transplantation 2001)
    3. Polymorphisms of interferon-gamma and interferon-gamma receptor 1 genes and pulmonary tuberculosis in Koreans. (PubMed id 17986123)1, 4, 9 Hwang J.H....Koh W.J. (Respirology 2007)
    4. Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan. (PubMed id 16961714)1, 4, 9 Wang T.N....Ko Y.C. (Clin. Exp. Allergy 2006)
    5. Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation. (PubMed id 12727483)1, 4, 9 Holweg C.T....Baan C.C. (Transpl. Immunol. 2003)
    6. Interleukin-4 (C-590T) and interferon-gamma (G5644A) gene polymorphisms in patients with periodontitis. (PubMed id 18230112)1, 4, 9 Hooshmand B....Ghasemi R. (J. Periodont. Res. 2008)
    7. Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL-10) in Down patients with coeliac disease. (PubMed id 16182624)1, 4, 9 Cataldo F....Corsello G. (Dig Liver Dis 2005)
    8. Combined analysis of interferon-gamma and interleukin-10 gene polymorphisms and chronic hepatitis C severity. (PubMed id 19480854)1, 4, 9 Bouzgarrou N....Chouchane L. (Hum. Immunol. 2009)
    9. [Single nucleotide polymorphism of interferon-gamma gene +874 T/A in patients with aplastic anemia]. (PubMed id 18426658)1, 4, 9 Chang H....Meng W.T. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    10. Genetic polymorphism of interferon-gamma, interferon-gamma receptor, and interferon regulatory factor-1 genes in patients with hepatitis B virus infection. (PubMed id 16944293)1, 4, 9 Cheong J.Y....Kim J.H. (Biochem. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3458 HGNC: 5438 AceView: IFNG Ensembl:ENSG00000111537 euGenes: HUgn3458
    ECgene: IFNG Kegg: 3458 H-InvDB: IFNG

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFNG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IFNG Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/506372/
    Wikipedia http://en.wikipedia.org/wiki/Interferon_gamma
    SeattleSNPshttp://pga.gs.washington.edu/data/ifng/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFNG gene:
    Search GeneIP for patents involving IFNG

    Licensable Technologies for IFNG gene:
    Weizmann Institute:Anti-inflammatory properties of low levels of IFN-g    (see all 2)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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