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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFNG Gene

protein-coding GIFtS: 68
GCID: GC12M068548

Interferon, Gamma

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Interferon, Gamma¹ ²
Immune Interferon² ³
IFN-gamma² ³
IFG² ⁵
IFI² ⁵
Interferon Gamma²

External Ids:	HGNC: 5438¹	Entrez Gene: 3458²	Ensembl: ENSG00000111537⁷	OMIM: 147570⁵	UniProtKB: P01579³

Export aliases for IFNG gene to outside databases

Previous GC identifers: GC12M068064 GC12M068352 GC12M068265 GC12M066834 GC12M065599

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNG Gene:

This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with

antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this

gene are associated with aplastic anemia.(provided by RefSeq, Nov 2009)

GeneCards Summary for IFNG Gene:

IFNG (interferon, gamma) is a protein-coding gene. Diseases associated with IFNG include leishmaniasis, and tuberculous uveitis, and among its related super-pathways are Type I diabetes mellitus and ER-Phagosome pathway. GO annotations related to this gene include interferon-gamma receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having

antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has

antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the

type I interferons

Gene Wiki entry for IFNG (Interferon-gamma) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.2 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFNG gene promoter:
ATF-2 CREB POU2F1 deltaCREB POU2F1b POU2F1a STAT3 POU2F1c Hlf Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFNG promoter sequence

Search SABiosciences Chromatin IP Primers for IFNG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q14

IFNG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNG gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M068548: view genomic region (about GC identifiers)

Start:	68,548,548 bp from pter	End:	68,553,527 bp from pter
Size:	4,980 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579 (See protein sequence)

Recommended Name: Interferon gamma precursor

Size: 166 amino acids; 19348 Da

Subunit: Homodimer

Subcellular location: Secreted

5 PDB 3D structures from and Proteopedia for IFNG:

1EKU (3D)

1FG9 (3D)

1FYH (3D)

1HIG (3D)

3BES (3D)

Secondary accessions: B5BU88 Q53ZV4

Explore the universe of human proteins at neXtProt for IFNG: NX_P01579

Explore proteomics data for IFNG at MOPED

Post-translational modifications:

UniProtKB: Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157

or Gly-161

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P01579

IFNG Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_000610.2

ENSEMBL proteins:

ENSP00000229135

Reactome Protein details: P01579
Human Recombinant Protein Products for IFNG:

	EMD Millipore Purified and/or Recombinant IFNG Protein
	R&D Systems Recombinant & Natural Proteins for IFNG (IFN-gamma)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for IFNG OriGene Custom MassSpec OriGene Custom Protein Services for IFNG
	GenScript Purified and Recombinant Proteins for IFNG
	Novus Biologicals IFNG Proteins Novus Biologicals IFNG Lysates
	Sino Biological Recombinant Protein for IFNG Sino Biological Cell Lysate for IFNG
	ProSpec Recombinant Protein for IFNG
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0009897	external side of plasma membrane	IEA	--

IFNG for ontologies About GeneDecksing

IFNG Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IFNG
	R&D Systems Antibodies for IFNG (IFN-gamma)
	Cell Signaling Technology (CST) Antibodies for IFNG
	OriGene Antibodies for IFNG OriGene Custom Antibody Services for IFNG
	GenScript Custom Superior Antibodies Services for IFNG
	Novus Biologicals IFNG Antibodies
	Abcam antibodies for IFNG
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for IFNG
	LSBio Antibodies in human, mouse, rat for IFNG

Assay Products for IFNG:

	EMD Millipore Kits and Assays for the Analysis of IFNG
	OriGene Custom Assay Services for IFNG
	R&D Systems Flow Cytometry Kits for IFNG (IFN-gamma) (see all)
	GenScript Custom Assay Services for IFNG
	Enzo Life Sciences assays for IFNG
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

IFN: Interferons

3 InterPro protein domains:

IPR012351 4_helix_cytokine_core

IPR009079 4_helix_cytokine-like_core

IPR002069 Interferon_gamma

Graphical View of Domain Structure for InterPro Entry P01579

ProtoNet protein and cluster: P01579

1 Blocks protein domain: IPB002069 Interferon gamma

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Similarity: Belongs to the type II (or gamma) interferon family

IFNG for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IFNG_HUMAN, P01579

Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having

antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has

antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the

type I interferons

Genatlas biochemistry entry for IFNG:

interferon type II,gamma,19.3kDa,expressed by lymphocytes,involved in immunoregulation

Summary:

IFNG as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Mature dendritic-like cells from Blood, Hematopoietic progenitor cells from Blood

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005133	interferon-gamma receptor binding	IEA	--

IFNG for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for IFNG:

Synthetic lethal with c-Myc af

15/24 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Ifng) (see all 24):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	liver/biliary system	mortality/aging	muscle

IFNG for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for IFNG: Ifng^tm1Ts Ifng^tm1Yiw

inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNG

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNG

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNG

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNG

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNG
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNG (see all 9):
		hsa-miR-3671 hsa-miR-607 hsa-miR-340 hsa-miR-633 hsa-miR-656 hsa-miR-3622b-3p hsa-miR-3121-3p hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: IFNG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for IFNG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNG

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IFNG
			Sirion Biotech Customized adenovirus for overexpression of IFNG

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for IFNG (see all 7) OriGene ORF clones in mouse, rat for IFNG OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNG (NM_000619)
		Sino Biological Human cDNA Clone for IFNG
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNG
		Sirion Biotech Customized lentivirus for stable overexpression of IFNG Customized lentivirus expression plasmids for stable overexpression of IFNG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IFNG
		Search LifeMap BioReagents cell lines for IFNG

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNG

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IFNG About (see all 61)

See pathways by source

SuperPath

Contained pathways About

Allograft rejection

Allograft rejection	0.69	THC Differentiation Pathway	0.37
Type I diabetes mellitus	0.69	Antigen processing and presentation	0.37
Graft-versus-host disease	0.65

CDK-mediated phosphorylation and removal of Cdc6

Proteasome

0.79

Proteasome Degradation

0.57

Toll Comparative Pathway

Immune response MIF in innate immunity response

0.46

iNOS Signaling

0.34

Immune response IFN gamma signaling pathway

Immune response IFN gamma signaling pathway

0.43

IFN-gamma pathway

0.43

IL27-mediated signaling events

IL27-mediated signaling events

0.38

Th1 Differentiation

0.38

Pathways by source See SuperPaths
Show all pathways

5/8 EMD Millipore Pathways for IFNG (see all 8)

	Immune response IFN gamma signaling pathway
	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Immune response Role of integrins in NK cells cytotoxicity
	Immune response CD16 signaling in NK cells
	Immune response IL-12-induced IFN-gamma production

3 R&D Systems Pathways for IFNG

	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Th1 Differentiation
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNG (see all 12)

	THC Differentiation Pathway
	Cytokine Network
	MSP-RON Signaling
	HMGB1 Pathway
	Interferon Pathway

1 Cell Signaling Technology (CST) Pathway for IFNG

Jak/Stat Pathway

5/10 GeneGo (Thomson Reuters) Pathways for IFNG (see all 10)

	Immune response MIF-mediated glucocorticoid regulation
	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Immune response CD16 signaling in NK cells

5/21 BioSystems Pathways for IFNG (see all 21)

	Cytokines and Inflammatory Response
	TGF Beta Signaling Pathway
	Senescence and Autophagy
	Type II interferon signaling (IFNG)
	Spinal Cord Injury

5 Reactome Pathways for IFNG

	Interferon gamma signaling
	Regulation of IFNG signaling
	Cytokine Signaling in Immune system
	Interferon Signaling
	Immune System

5/28 Kegg Pathways (Kegg details for IFNG) (see all 28):

	Proteasome
	Cytokine-cytokine receptor interaction
	HIF-1 signaling pathway
	Regulation of autophagy
	TGF-beta signaling pathway

IFNG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IFNG

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/83 Interacting proteins for IFNG (P01579³ ENSP00000229135⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 83)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNF	P01375³, ENSP00000398698⁴	I2D: score=2 STRING: ENSP00000398698
ENSG00000204490	P01375³	I2D: score=2
ENSG00000206439	P01375³	I2D: score=2
ENSG00000223952	P01375³	I2D: score=2
ENSG00000228321	P01375³	I2D: score=2

About this table

Gene Ontology (GO): 5/66 biological process terms (GO ID links to tree view) (see all 66): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IDA	15604419
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0001781	neutrophil apoptotic process	IEA	--
GO:0002026	regulation of the force of heart contraction	IEA	--
GO:0002053	positive regulation of mesenchymal cell proliferation	ISS	--

IFNG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IFNG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNG

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Pharmaceutical: Available under the name Actimmune (Genentech). Used for reducing the frequency and severity of

serious infections associated with chronic granulomatous disease (CGD)

1 HMDB Compound for IFNG About this table

Compound	Synonyms	CAS #	PubMed Ids
Simvastatin	(+)-Simvastatin (see all 28)	79902-63-9	--

2 DrugBank Compounds for IFNG About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glucosamine	--	3416-24-8	target	--	16431966 16155294 17238806 16709188
Olsalazine	--	15722-48-2	target	--	17034586 9797390

10/121 Novoseek inferred chemical compound relationships for IFNG gene (see all 121) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	82.3	559	11970912 (6), 9527395 (6), 10792507 (5), 11172624 (5) (see all 99)
tuberculin	81.7	291	16126802 (4), 19732759 (4), 12491197 (3), 17682705 (3) (see all 99)
indoleamine	81.5	174	10729320 (4), 15070879 (3), 1398953 (2), 7523670 (2) (see all 99)
neopterin	80.5	442	1341444 (5), 10361231 (5), 1909303 (5), 17657857 (5) (see all 99)
il 10	79.5	249	12394188 (4), 8902857 (3), 11745683 (3), 19274101 (3) (see all 99)
ionomycin	75.5	228	9876227 (3), 15735428 (3), 16600192 (3), 1971531 (2) (see all 99)
il-12	70.7	91	11479428 (5), 18708162 (4), 15122806 (3), 15140777 (3) (see all 53)
nitric oxide	69.7	1599	11069732 (6), 10583599 (6), 1517576 (6), 9328118 (6) (see all 99)
alpha-galactosylceramide	69.2	42	12902477 (2), 15173890 (2), 15599405 (1), 15749842 (1) (see all 35)
kynurenine	68.1	101	1465184 (5), 8288893 (4), 18823288 (4), 1909303 (4) (see all 53)

Search CenterWatch for drugs/clinical trials and news about IFNG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNG gene:

NM_000619.2

Unigene Cluster for IFNG:

Interferon, gamma

Hs.856 [show with all ESTs]

Unigene Representative Sequence: BC070256

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000229135(uc001stw.1)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNG
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNG (see all 9):
		hsa-miR-3671 hsa-miR-607 hsa-miR-340 hsa-miR-633 hsa-miR-656 hsa-miR-3622b-3p hsa-miR-3121-3p hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: IFNG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for IFNG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNG

Clone Products:		OriGene clones in human, mouse for IFNG (see all 7) OriGene ORF clones in mouse, rat for IFNG OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNG (NM_000619)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNG
		Sirion Biotech Customized lentivirus for stable overexpression of IFNG Customized lentivirus expression plasmids for stable overexpression of IFNG

Primer Products:		OriGene qPCR primer pairs and template standards for IFNG OriGene qSTAR qPCR primer pairs in human, mouse for IFNG
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IFNG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNG

Additional mRNA sequence:

AB451324.1 AB451453.1 AF506749.1 AM903379.1 AY044154.1 AY255837.1 AY255839.1 BC070256.1

EF173872.1 V00543.1 X01992.1 X13274.1 X62468.1 X62469.1 X62470.1 X62471.1

X62472.1 X62473.1 X62474.1 X87308.1

3 DOTS entries:

DT.413894 DT.413893 DT.91824036

24/40 AceView cDNA sequences (see all 40):

AA381654 V00543 NM_000619 AA381839 BG230744 AA969504 X13274 T29780

CD520458 X01992 CD638881 AY255837 CD520994 AY044154 AA381667 AA381733

AA381626 AF506749 AY255839 CD640310 CD639121 BC070256 AA381921 X87308

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNG expression in normal human tissues (normalized intensities) IFNG embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCTGGTGCTT

About this image

IFNG expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/8 selected tissues (see all 8) fully expand


Blood (Hematopoietic System) fully expand to see all 6 entries
Bone marrow-derived hematopoietic stem cells
cd8+ t cell

Endothelium (Cardiovascular System) fully expand to see all 2 entries
colon ; endothelial cells
cd31+ cells

Colon (Gastrointestinal Tract) fully expand to see all 2 entries
colon ; endothelial cells

Oral Cavity (Gastrointestinal Tract)
salivary gland ; glandular cells

Lung (Respiratory System)
bronchus ; respiratory epithelial cells

See IFNG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNG

SOURCE GeneReport for Unigene cluster: Hs.856

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Tissue specificity: Released primarily from activated T lymphocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including IFNG (see all 41):

Multiple Sclerosis in human mouse rat

Interferons & Receptors in human mouse rat

Wound Healing in human mouse rat

Lymphoma in human mouse rat

Inflammasomes in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for IFNG OriGene qSTAR qPCR primer pairs in human, mouse for IFNG
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IFNG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNG

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFNG gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ifng^{1 , 5}	interferon gamma^{1, 5}	62.99(n)¹ 41.56(a)¹		10 (66.75 cM)⁵ 15978¹ NM_008337.3¹ NP_032363.1¹ 118441047⁵
chicken (Gallus gallus)	Aves	IFNG⁶	Interferon gamma	32(a)	1 ↔ 1	1(35013708-35017857)

ENSEMBL Gene Tree for IFNG (if available)
TreeFam Gene Tree for IFNG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121913166^1,2	C	untested¹	68388602(-)	`AGGCTC/GTCTGT`	1	--	int¹		0	--	--	--	--
rs121913164^1,2	C	untested¹	68388823(-)	`TACTAC/TTTCCA`	1	--	int¹		0	--	--	--	--
VAR_004017⁴		--	--	see VAR_004017	2	K Q	mis⁴		0	--	--	--	--
VAR_004018⁴		--	--	see VAR_004018	2	R Q	mis⁴		0	--	--	--	--
rs200936524^1,2	C	--	65605834(+)	`CATTTC/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs2069736^1,2	C,F	--	68385334(-)	`GTTTCA/TGCTTT`	1	--	ds500¹		5		NS NA	214
rs2069735^1,2	C	--	68385353(-)	`CATTAT/CGTATA`	1	--	ds500¹		4		NS NA	94
rs2069727^1,2	C,F,A,H	--	68385491(-)	`CCTTCA/GTTTCA`	1	--	ds500¹		27		NS NA EA WA	3118
rs2069726^1,2	C,F	--	68385500(-)	`CTATTT/CCCTCC`	1	--	ds500¹		4		NS WA	210
rs4394909^1,2	H	--	68385525(+)	`GGCTAG/AAAATA`	1	--	ds500¹		4		NS EA	410

HapMap Linkage Disequilibrium report for IFNG (68548548 - 68553527 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for IFNG: --

Human Gene Mutation Database (HGMD): IFNG

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing IFNG

DNA2.0 Custom Variant and Variant Library Synthesis for IFNG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 147570
OMIM disorders: 613254 609135 607948 609423 609532
UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate

numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia.

Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry

20/515 diseases for IFNG (see all 515): About MalaCards

leishmaniasis tuberculous uveitis eosinophilic pustular folliculitis mucocutaneous leishmaniasis

autoimmune progesterone dermatitis aids, rapid progression to aplastic anemia, ifng-related hepatitis c virus, response to therapy of

visceral leishmaniasis acute retinal necrosis syndrome buruli ulcer disease neurosarcoidosis

tinea unguium pleural tuberculosis folliculitis dermatophytosis

tinea pedis interferon gamma, receptor 1, deficiency tuberculous peritonitis t-cell/histiocyte rich large b cell lymphoma

5 diseases from the University of Copenhagen DISEASES database for IFNG:

Aspergillosis Fusariosis Candidiasis Tuberculosis

Trichosporonosis

IFNG for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/97 Novoseek inferred disease relationships for IFNG gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	92.8	7943	2124085 (5), 18973545 (5), 8551280 (5), 12352046 (5) (see all 99)
tumors	86.1	8074	1717132 (6), 8425194 (6), 9621132 (6), 8402732 (6) (see all 99)
inflammation	81.3	562	17404615 (5), 19098321 (4), 9057354 (3), 10207939 (3) (see all 99)
tuberculosis	79.2	1312	16493060 (7), 10490990 (6), 14978096 (6), 16207403 (5) (see all 99)
autoimmune diseases	76.4	106	18775671 (4), 9883078 (3), 1746015 (2), 11037964 (2) (see all 80)
dermatitis atopic	74.5	286	11978138 (7), 9930598 (6), 7622767 (5), 8086777 (4) (see all 99)
tuberculosis active	73.6	54	19797760 (4), 15751711 (2), 19339489 (2), 12821809 (1) (see all 44)
multiple sclerosis	72	219	10404403 (4), 9626770 (4), 9310963 (3), 10694841 (3) (see all 99)
granulomatous disease chronic	70.9	91	1905138 (2), 1572085 (2), 8084323 (2), 1846940 (2) (see all 70)
virus infection	69.1	259	8070686 (4), 15999001 (3), 11983129 (3), 9649578 (2) (see all 99)

Genetic Association Database (GAD): IFNG
Human Genome Epidemiology (HuGE) Navigator: IFNG (543 documents)

Export disorders for IFNG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFNG gene, integrated from 9 sources (see all 9241):
(articles sorted by number of sources associating them with IFNG)

Utopia: connect your pdf to the dynamic
world of online information

Homozygosis for (12) CA repeats in the first intron of the human IFN- gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. (PubMed id 15327519)^{1, 2, 4, 9} Dufour C.... Iolascon A. (2004)
Association of polymorphisms in the human interferon-gamma and interleukin-10 gene with acute and chronic kidney transplant outcome: the cytokine effect on transplantation. (PubMed id 11292301)^{1, 4, 9} Asderakis A....Hutchinson I.V. (2001)
Polymorphisms of interferon-gamma and interferon-gamma receptor 1 genes and pulmonary tuberculosis in Koreans. (PubMed id 17986123)^{1, 4, 9} Hwang J.H....Koh W.J. (2007)
Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan. (PubMed id 16961714)^{1, 4, 9} Wang T.N....Ko Y.C. (2006)
Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation. (PubMed id 12727483)^{1, 4, 9} Holweg C.T....Baan C.C. (2003)
Interleukin-4 (C-590T) and interferon-gamma (G5644A) gene polymorphisms in patients with periodontitis. (PubMed id 18230112)^{1, 4, 9} Hooshmand B....Ghasemi R. (2008)
Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL-10) in Down patients with coeliac disease. (PubMed id 16182624)^{1, 4, 9} Cataldo F....Corsello G. (2005)
Combined analysis of interferon-gamma and interleukin -10 gene polymorphisms and chronic hepatitis C severity. (PubMed id 19480854)^{1, 4, 9} Bouzgarrou N....Chouchane L. (2009)
[Single nucleotide polymorphism of interferon-gamma gene +874 T/A in patients with aplastic anemia] (PubMed id 18426658)^{1, 4, 9} Chang H....Meng W.T. (2008)
Genetic polymorphism of interferon-gamma, interferon-gamma receptor, and interferon regulatory factor-1 genes in patients with hepatitis B virus infection. (PubMed id 16944293)^{1, 4, 9} Cheong J.Y....Kim J.H. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3458	HGNC: 5438	AceView: IFNG	Ensembl:ENSG00000111537	euGenes: HUgn3458
ECgene: IFNG	Kegg: 3458	H-InvDB: IFNG

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFNG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IFNG	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/IFNG
Wikipedia	http://en.wikipedia.org/wiki/Interferon_gamma
SeattleSNPs	http://pga.gs.washington.edu/data/ifng/

Intellectual Property for IFNG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IFNG gene:
Search GeneIP for patents involving IFNG

Licensable Technologies for IFNG gene:

Weizmann Institute:

Anti-inflammatory properties of low levels of IFN-g

(see all 2)

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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