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IFNG Gene

protein-coding GIFtS: 69

GC12M066834

interferon, gamma
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
IFG ^², ⁵
IFI ^², ⁵
IFN-gamma ^³

Descriptions
Immune interferon ^³
interferon, gamma ^²

External Ids
HGNC: 5438¹
Entrez Gene: 3458²
UniProtKB: P01579³
Ensembl: ENSG00000111537⁷

Search outside databases for aliases for IFNG gene

Previous GC identifers: GC12M068064 GC12M068352 GC12M068265

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IFNG:

Interferon-gamma (IFNG), or type II interferon, is a cytokine critical for innate and adaptive

immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFNG

expression is associated with a number of autoinflammatory and autoimmune diseases. The importance

of IFNG in the immune system stems in part from its ability to inhibit viral replication directly,

but most importantly derives from its immunostimulatory and immunomodulatory effects. IFNG is

produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the

innate immune response, and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte

(CTL) effector T cells once antigen-specific immunity develops (Schoenborn and Wilson, 2007

[PubMed 17981204]).[supplied by OMIM]

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in

addition to having antiviral activity, has important immunoregulatory functions. It is a potent

activator of macrophages, it has antiproliferative effects on transformed cells and it can

potentiate the antiviral and antitumor effects of the type I interferons

Gene Wiki entry for IFNG (Interferon-gamma)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IFNG gene

Entrez Gene cytogenetic band: 12q14 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q14

IFNG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M066834: (about GC identifiers)

Start:	66,834,816 bp from pter
End:	66,839,790 bp from pter
Size:	4,975 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579 (See protein sequence)

Recommended Name: Interferon gamma precursor

Size: 166 amino acids; 19348 Da

Subunit: Homodimer

Subcellular location: Secreted

PDB structures from and Proteopedia :

1EKU (3D)

1FG9 (3D)

1FYH (3D)

1HIG (3D)

3BES (3D)

Post-translational modifications:

Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at

Gly-150, Met-157 or Gly-161¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000610.2

ENSEMBL proteins:

ENSP00000229135

Human Recombinant Proteins

	Invitrogen human recombinant proteins for IFNG
	Millipore Purified and/or Recombinant IFNG Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IFNG (IFN-gamma)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Interferon Gamma + Perforin, Interferon gamma + IL10, Interferon gamma + IL5, Interferon Gamma + IL2, Interferon Gamma + Granzyme B, Interferon gamma, Interferon gamma + IL4)
	Human Recombinant Proteins from Abnova (IFNG)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

About this table

Antibodies for IFNG:

	Invitrogen Antibodies for IFNG
	Millipore Mono- and Polyclonal Antibodies for the study of IFNG
	Sigma-Aldrich Antibodies for IFNG
	R&D Systems Antibodies for IFNG (IFN-gamma)
	Cell Signaling Technology (CST) Antibodies for IFNG (IFN-gamma)
	Antibodies from Abcam (Interferon Gamma + Perforin, Interferon gamma + IL10, Interferon gamma + IL5, Interferon Gamma + IL2, Interferon Gamma + Granzyme B, Interferon gamma, Interferon gamma + IL4), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for IFNG

Assays for IFNG:

	Invitrogen Assays for IFNG
	Millipore Kits and Assays for the Analysis of IFNG
	R&D Systems ELISAs for IFNG (IFN-gamma) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01579

ProtoNet protein and cluster: P01579

1 Blocks protein family: IPB002069 Interferon gamma

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Similarity: Belongs to the type II (or gamma) interferon family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFNG)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000619

Applied Biosystems Silencer® siRNAs for IFNG

Sigma-Aldrich siRNA and siRNA Panels for IFNG

Sigma-Aldrich shRNA Panels and shRNA for IFNG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IFNG
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000619
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000619
untagged cDNA clone in CMV expression vector: NM_000619

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000619

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in

addition to having antiviral activity, has important immunoregulatory functions. It is a potent

activator of macrophages, it has antiproliferative effects on transformed cells and it can

potentiate the antiviral and antitumor effects of the type I interferons

Genatlas biochemistry entry for IFNG:

interferon type II,gamma,19.3kDa,expressed by lymphocytes,involved in immunoregulation

15/17 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ifng) (see all 17 ):

	cellular	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	life span-post-weaning/aging
liver/biliary system	no phenotypic analysis	normal	renal/urinary system	respiratory system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005133	interferon-gamma receptor binding	TAS	10477596

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/14 Sigma-Aldrich "Your Favorite Gene" Pathways for IFNG (Your Favorite Gene powered by Ingenuity) (see all 14 )

T Helper Cell Differentiation
Role of PKR in Interferon Induction and Antiviral Response
Hepatic Cholestasis
Hepatic Fibrosis / Hepatic Stellate Cell Activation
Allograft Rejection Signaling

GeneDecks IFNG for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IFNG

5/419 Interacting proteins for IFNG (ENSP00000229135³) via UniProtKB, MINT, and/or STRING (see all 419 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HLA-C	ENSP00000365412³	STRING (score=.904) STRING (score=.819)
SEPP1	ENSP00000373479³	STRING (score=.839)
CCR5	ENSP00000292303³	STRING (score=.999)
CD4	ENSP00000011653³	STRING (score=.999)
CD80	ENSP00000264246³	STRING (score=.999)

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5/30 Gene Ontology (GO) biological process terms (links to tree view) (see all 30 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IDA	15604419
GO:0001781	neutrophil apoptosis	IEA	--
GO:0006925	inflammatory cell apoptosis	IEA	--
GO:0006928	cell motion	TAS	10477596
GO:0007050	cell cycle arrest	IDA	16942485

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for IFNG:

Antagonist

Browse Tocris compounds for IFNG
UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

Pharmaceutical: Available under the name Actimmune (Genentech). Used for reducing the frequency and

severity of serious infections associated with chronic granulomatous disease (CGD)

10/20 Novoseek chemical compound relationships for IFNG gene (see all 20 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	82.14	524	11970912 (6), 9527395 (6), 10792507 (5), 11172624 (5) (see all 99)
indoleamine	81.13	166	10729320 (4), 15070879 (3), 1398953 (2), 7523670 (2) (see all 99)
neopterin	80.80	432	1341444 (5), 10361231 (5), 1909303 (5), 17657857 (5) (see all 99)
il 10	79.07	219	12394188 (4), 8902857 (3), 11745683 (3), 19274101 (3) (see all 99)
tuberculin	78.11	226	16126802 (4), 12491197 (3), 17682705 (3), 7960152 (2) (see all 99)
ionomycin	75.23	220	9876227 (3), 15735428 (3), 16600192 (3), 1971531 (2) (see all 99)
il-12	70.25	80	11479428 (5), 18708162 (4), 15122806 (3), 15140777 (3) (see all 48)
nitric oxide	69.84	1535	11069732 (6), 10583599 (6), 1517576 (6), 9328118 (6) (see all 99)
kynurenine	67.86	98	1465184 (5), 8288893 (4), 18823288 (4), 1909303 (4) (see all 52)
alpha-galactosylceramide	67.35	35	12902477 (2), 15173890 (2), 15599405 (1), 15749842 (1) (see all 29)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFNG)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000619

Sigma-Aldrich siRNA and siRNA Panels for IFNG

Sigma-Aldrich shRNA Panels and shRNA for IFNG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000619

REFSEQ mRNAs for IFNG gene:

NM_000619.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000619

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000619
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000619
                                 untagged cDNA clone in CMV expression vector: NM_000619

Additional cDNA sequence:

AB451324.1 AB451453.1 AF506749.1 AM903379.1 AY044154.1 AY255837.1 AY255839.1 BC070256.1

EF173872.1 V00543.1 X01992.1 X13274.1 X62468.1 X62469.1 X62470.1 X62471.1

X62472.1 X62473.1 X62474.1 X87308.1

3 DOTS entries:

DT.413894 DT.413893 DT.91824036

24/40 AceView cDNA sequences (see all 40 ):

AA969504 AA381654 V00543 NM_000619 T29780 X13274 BG230744 AA381839

AA381626 CD520458 AY044154 BC070256 X87308 CD520994 X01992 AA381921

AY255837 CD639121 CD640310 AA381667 AF506749 AA381733 CD638881 AY255839

highest scoring ESTs for IFNG:

X13274 AA381613 AA381626 AA381629 AA381654 AA381667 AA381733 AA381839 AA381921 AF506749

Unigene Cluster for IFNG:

Interferon, gamma

Hs.856 [show with all ESTs]

Unigene Representative Sequence: BC070256

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000229135

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFNG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFNG

¹ / ² / ³

5 probe-sets matching IFNG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1021_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.23	J00219	0.20	1.00	0.72	1
40702_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.90	X13274	1.00	1.00	1.00	1
1611_s_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.96	J00219	0.20	1.00	0.72	1
210354_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M29383	0.20	1.00	0.72	1
210354_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IFNG for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTGGTGCTT

SOURCE GeneReport for Unigene cluster: Hs.856
Expression variation in blood from EXPOLDB for IFNG
UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579
Tissue specificity: Released primarily from activated T lymphocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IFNG gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IFNG¹	--	interferon gamma	77.71(n) 65.66(a)	403801 NM_001003174.1 NP_001003174.1
chimpanzee (Pan troglodytes)	IFNG¹	--	interferon, gamma	99.2(n) 99.4(a)	449517 XM_001151968.1 XP_001151968.1
cow (Bos taurus)	IFNG¹	--	interferon, gamma	75.35(n) 61.82(a)	281237 NM_174086.1 NP_776511.1
rat (Rattus norvegicus)	Ifng¹	--	interferon gamma	60.65(n) 39.35(a)	25712 NM_138880.2 NP_620235.1
mouse (Mus musculus)	Ifng^{1, 5}	10 (67.00 cM)⁵	interferon gamma^{1, 5}	62.99(n)¹ 41.56(a)¹	15978¹ NM_008337.2¹ NP_032363.1¹ AK089574⁵ AY423847⁵ (see all 13)

About this table Species with no ortholog for IFNG

ENSEMBL Gene Tree for IFNG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/94 NCBI SNPs in IFNG are shown (see all 94 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 58)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2069705^1,2	A,C,F,H	66841278(-)	`AGAAGT/CTAACT`	1	--	ng3¹		11	NS MN CSAM EA WA	1742
	rs2069727^1,2	A,C,F,H	66834490(-)	`CCTTCA/GTTTCA`	1	--	ng5¹		13	NS NA EU EA WA	1190
--	rs2069707^1,2	C,F,H	66840555(-)	`ATTCTC/GTACAC`	1	--	ng3¹		13	NS NA EA WA	2036
	rs2069725^1,2	C,F,H	66834653(-)	`CTTTCG/ACTTTT`	1	--	ng5¹		12	NS EU EA WA	1158
	rs2069724^1,2	C,F,H	66834782(-)	`TGAGAC/TCTGGA`	1	--	ng5¹		10	NS EU EA WA	924
--	rs2069734^1,2	C,F,H	66835277(-)	`CAACTT/ATTGTG`	1	--	ut3¹		11	NS MN CSAM EA EU WA	890
	rs2069709^1,2	C,F,H	66839970(-)	`TCAAAG/TGACCC`	1	--	ng3¹		9	NS NA EU EA WA	640
	rs2069723^1,2	C,F,H	66834861(-)	`GTTAAA/GATTAT`	1	--	ut3¹		11	NS EU EA WA MN CSAM	886
--	rs2069722^1,2	C,F,H	66835220(-)	`ATATCC/TTGTGA`	1	--	ut3¹ ese³		18	NS EU EA WA MN CSAM NA	1456
	rs2069731^1,2	C,F,H	66841224(-)	`TGCCCC/TATAAC`	1	--	ng3¹		11	NS MN CSAM EA EU WA	898

About this table

HapMap Linkage Disequilibrium images for IFNG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147570 disorders: 191100 609135 607948 609423 609532

UniProtKB/Swiss-Prot: IFNG_HUMAN, P01579

In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia

(AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells

results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion

is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and

most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn

be able to suppress hematopoiesis

10/97 Novoseek disease relationships for IFNG gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	92.80	7476	2124085 (5), 18973545 (5), 8551280 (5), 12352046 (5) (see all 99)
tumors	85.89	7545	1717132 (6), 8425194 (6), 9621132 (6), 8402732 (6) (see all 99)
inflammation	80.76	515	17404615 (5), 19098321 (4), 9057354 (3), 10207939 (3) (see all 99)
tuberculosis	77.06	1118	16493060 (7), 10490990 (6), 14978096 (6), 16207403 (5) (see all 99)
autoimmune diseases	75.59	100	18775671 (4), 9883078 (3), 1746015 (2), 11037964 (2) (see all 76)
dermatitis atopic	74.38	269	11978138 (7), 9930598 (6), 7622767 (5), 8086777 (4) (see all 99)
multiple sclerosis	71.86	211	10404403 (4), 9626770 (4), 9310963 (3), 10694841 (3) (see all 99)
granulomatous disease chronic	71.10	89	1905138 (2), 1572085 (2), 8084323 (2), 1846940 (2) (see all 68)
tuberculosis active	68.69	36	15751711 (2), 12821809 (1), 16493157 (1), 17601979 (1) (see all 31)
virus infection	68.29	242	8070686 (4), 15999001 (3), 11983129 (3), 9649578 (2) (see all 99)

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1 PharmGKB disease relationship for IFNG gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Inflammation	CO GN	11404167

About this table

Human Gene Mutation Database: IFNG
Genetic Association Database: IFNG
Human Genome Epidemiology Navigator: IFNG (380 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/7297 PubMed articles for IFNG gene (see all 7297 ):

Homozygosis for (12) CA repeats in the first intron of the human IFN- gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. (PubMed id 15327519)^{3, 4, 6} Dufour C.... Iolascon A. (2004)
The effect of cytokine gene polymorphisms on pediatric heart allograft outcome. (PubMed id 11404167)^{3, 6, 7} Awad M.R....Zeevi A. (2001)
Association of polymorphisms in the human interferon-gamma and interleukin-10 gene with acute and chronic kidney transplant outcome: the cytokine effect on transplantation. (PubMed id 11292301)^{1, 3, 6} Asderakis A....Hutchinson I.V. (2001)
Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation. (PubMed id 12727483)^{1, 3, 6} Holweg C.T....Baan C.C. (2003)
Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL-10) in Down patients with coeliac disease. (PubMed id 16182624)^{1, 3, 6} Cataldo F....Corsello G. (2005)
Polymorphism of cytokine genes (TGF-beta1, IFN-gamma, IL-6, IL-10, and TNF-alpha) in patients with chronic pancreatitis. (PubMed id 15841043)^{1, 3, 6} Bendicho M.T....Lemaire D.C. (2005)
The effects of interleukin 10 and interferon gamma cytokine gene polymorphisms on survival after autologous bone marrow transplantation for patients with breast cancer. (PubMed id 15931634)^{1, 3, 6} Wu J.M....Hess A.D. (2005)
Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region. (PubMed id 15858598)^{1, 3, 6} Koch O....Kwiatkowski D. (2005)
Polymorphisms in tumour necrosis factor-alpha, transforming growth factor-beta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infection. (PubMed id 12938195)^{1, 3, 6} Barrett S....Crowe J. (2003)
[Polymorphism of TNF-alpha (308 A/G), IL-10 (1082 A/G, 819 C/T 592 A/C), IL-6 (174 G/C), and IFN-gamma (874 A/T); genetically conditioned cytokine synthesis level in children with diabetes type 1] (PubMed id 12818128)^{1, 3, 6} Siekiera U....Koehler B. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3458	HGNC: 5438	AceView: IFNG	Ensembl:ENSG00000111537	euGenes: HUgn3458
ECgene: IFNG	H-InvDB: IFNG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IFNG	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=IFNG
Wikipedia	http://en.wikipedia.org/wiki/Interferon_gamma
SeattleSNPs	http://pga.gs.washington.edu/data/ifng/

Licensable Technologies for IFNG
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for IFNG gene:

Weizmann Institute:

Anti-inflammatory properties of low levels of IFN-g

(see all 2)

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IFNG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFNG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IFNG		Antibodies for IFNG
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IFNG		Small molecules for IFNG
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IFNG)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for IFNG (IFN-gamma)

	Recombinant Proteins (Interferon Gamma + Perforin, Interferon gamma + IL10, Interferon gamma + IL5, Interferon Gamma + IL2, Interferon Gamma + Granzyme B, Interferon gamma, Interferon gamma + IL4)
	Antibodies (Interferon Gamma + Perforin, Interferon gamma + IL10, Interferon gamma + IL5, Interferon Gamma + IL2, Interferon Gamma + Granzyme B, Interferon gamma, Interferon gamma + IL4)

Search OriGene for IFNG

Search Tocris compounds for IFNG

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IFNG

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IFNG Gene at Home site.
Version 2.41.1
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IFNG Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for IFNG

Summaries
for IFNG

Genomic Location
for IFNG

Proteins
for IFNG

Protein Domains/
Families
for IFNG

Gene Function
for IFNG

Pathways & Interactions
for IFNG

Drugs & Compounds
for IFNG

Transcripts
for IFNG

Expression
for IFNG

Orthologs
for IFNG

Paralogs
for IFNG

SNPs/Variants
for IFNG

Disorders & Mutations
for IFNG

Medical News
for IFNG

Publications
for IFNG

Search for IFNG

Genome Databases showing IFNG

Other Databases showing IFNG

Specialized Databases showing IFNG

Licensable Technologies
for IFNG

Services
for IFNG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFNG Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor IFNG

Summariesfor IFNG

Genomic Locationfor IFNG

Proteinsfor IFNG

Protein Domains/Familiesfor IFNG

Gene Functionfor IFNG

Pathways & Interactionsfor IFNG

Drugs & Compoundsfor IFNG

Transcriptsfor IFNG

Expression for IFNG

Orthologsfor IFNG

Paralogsfor IFNG

SNPs/Variantsfor IFNG

Disorders & Mutationsfor IFNG

Medical Newsfor IFNG

Publicationsfor IFNG

Search for IFNG

Genome Databases showing IFNG

Other Databases showing IFNG

Specialized Databases showing IFNG

Licensable Technologiesfor IFNG

Servicesfor IFNG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFNG

Summaries
for IFNG

Genomic Location
for IFNG

Proteins
for IFNG

Protein Domains/
Families
for IFNG

Gene Function
for IFNG

Pathways & Interactions
for IFNG

Drugs & Compounds
for IFNG

Transcripts
for IFNG

Expression
for IFNG

Orthologs
for IFNG

Paralogs
for IFNG

SNPs/Variants
for IFNG

Disorders & Mutations
for IFNG

Medical News
for IFNG

Publications
for IFNG

Licensable Technologies
for IFNG

Services
for IFNG