External Ids for IFNG Gene
Previous GeneCards Identifiers for IFNG Gene
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
GeneCards Summary for IFNG Gene
IFNG (Interferon, Gamma) is a Protein Coding gene. Diseases associated with IFNG include Aplastic Anemia and Hepatitis C Virus. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Th17 Differentiation Pathway. GO annotations related to this gene include cytokine activity and interferon-gamma receptor binding.
UniProtKB/Swiss-Prot for IFNG Gene
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.