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Aliases for IFNE Gene

Aliases for IFNE Gene

  • Interferon Epsilon 2 3 5
  • IFN-Epsilon 3 4
  • IFNE1 3 4
  • Interferon Epsilon 1 3
  • Interferon Epsilon-1 4
  • Interferon Tau-1 3
  • PRO655 3
  • IFN-E 3
  • IFNT1 3
  • INFE1 3

External Ids for IFNE Gene

Previous GeneCards Identifiers for IFNE Gene

  • GC09M021470
  • GC09M021444

Summaries for IFNE Gene

GeneCards Summary for IFNE Gene

IFNE (Interferon Epsilon) is a Protein Coding gene. Among its related pathways are Type I Interferon Signaling Pathways and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA1.

UniProtKB/Swiss-Prot for IFNE Gene

  • Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2-5-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNE Gene

Genomics for IFNE Gene

Regulatory Elements for IFNE Gene

Enhancers for IFNE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G021547 1.5 Ensembl ENCODE dbSUPER 4.6 -72.7 -72671 14.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF121 GLIS2 GATA2 ZNF302 FOS SP3 MIR31 IFNE MIR31HG GC09M021524
GH09G021503 0.9 Ensembl ENCODE 4.6 -23.8 -23775 4.3 JUN CEBPB EP300 JUND MAFF POLR2A STAT3 RCOR1 FOS MAFK IFNWP2 IFNA8 IFNA12P IFNA20P IFNE GC09P021512
GH09G021542 0.8 ENCODE dbSUPER 4.9 -61.1 -61051 1.5 MAFF GATA2 TEAD4 MAFK MIR31 IFNE GC09M021524 MIR31HG
GH09G021545 0.2 dbSUPER 5 -63.4 -63380 1.1 MIR31 IFNE MIR31HG GC09M021524
GH09G021481 0.8 Ensembl ENCODE 0.7 +0.6 558 0.7 IKZF1 RELB PRDM1 IKZF2 IFNE GC09P021456
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFNE on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNE Gene

Chromosome:
9
Start:
21,480,839 bp from pter
End:
21,482,313 bp from pter
Size:
1,475 bases
Orientation:
Minus strand

Genomic View for IFNE Gene

Genes around IFNE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNE Gene

Proteins for IFNE Gene

  • Protein details for IFNE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WN2-IFNE_HUMAN
    Recommended name:
    Interferon epsilon
    Protein Accession:
    Q86WN2

    Protein attributes for IFNE Gene

    Size:
    208 amino acids
    Molecular mass:
    24414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNE Gene

Post-translational modifications for IFNE Gene

  • Glycosylation at isoforms=95 and posLast=104104
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNE Gene

Domains & Families for IFNE Gene

Suggested Antigen Peptide Sequences for IFNE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WN2

UniProtKB/Swiss-Prot:

IFNE_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNE: view

No data available for Gene Families for IFNE Gene

Function for IFNE Gene

Molecular function for IFNE Gene

UniProtKB/Swiss-Prot Function:
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2-5-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).
UniProtKB/Swiss-Prot Induction:
By estrogens.

Gene Ontology (GO) - Molecular Function for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA,IEA --
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNE: view
genes like me logo Genes that share phenotypes with IFNE: view

Animal Models for IFNE Gene

MGI Knock Outs for IFNE:

Animal Model Products

  • Taconic Biosciences Mouse Models for IFNE

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IFNE

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNE Gene

Localization for IFNE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNE Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNE gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with IFNE: view

Pathways & Interactions for IFNE Gene

genes like me logo Genes that share pathways with IFNE: view

Pathways by source for IFNE Gene

Gene Ontology (GO) - Biological Process for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNE: view

No data available for SIGNOR curated interactions for IFNE Gene

Drugs & Compounds for IFNE Gene

No Compound Related Data Available

Transcripts for IFNE Gene

mRNA/cDNA for IFNE Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNE Gene

Interferon, epsilon:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IFNE

Alternative Splicing Database (ASD) splice patterns (SP) for IFNE Gene

No ASD Table

Relevant External Links for IFNE Gene

GeneLoc Exon Structure for
IFNE
ECgene alternative splicing isoforms for
IFNE

Expression for IFNE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNE Gene

mRNA differential expression in normal tissues according to GTEx for IFNE Gene

This gene is overexpressed in Esophagus - Mucosa (x6.0) and Bladder (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of IFNE Gene:

IFNE

SOURCE GeneReport for Unigene cluster for IFNE Gene:

Hs.682604

mRNA Expression by UniProt/SwissProt for IFNE Gene:

Q86WN2-IFNE_HUMAN
Tissue specificity: Endometrium-specific.

Evidence on tissue expression from TISSUES for IFNE Gene

  • Lung(3.7)
  • Bone(3.6)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with IFNE: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNE Gene

Orthologs for IFNE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNE 34 35
  • 99.2 (n)
cow
(Bos Taurus)
Mammalia IFNE 34 35
  • 83.86 (n)
dog
(Canis familiaris)
Mammalia IFNE 35
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifne 34
  • 72.63 (n)
mouse
(Mus musculus)
Mammalia Ifne 34 16 35
  • 71.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IFN4 35
  • 38 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC101750245 34
  • 53.18 (n)
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
Species where no ortholog for IFNE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNE Gene

ENSEMBL:
Gene Tree for IFNE (if available)
TreeFam:
Gene Tree for IFNE (if available)

Paralogs for IFNE Gene

(18) SIMAP similar genes for IFNE Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFNE Gene

genes like me logo Genes that share paralogs with IFNE: view

Variants for IFNE Gene

Sequence variations from dbSNP and Humsavar for IFNE Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000775958 -- 21,483,807(+) AATAG(G/T)TTAAG intron-variant, upstream-variant-2KB
rs1001436179 -- 21,481,980(+) TAGTC(A/G)TCCAA intron-variant, utr-variant-5-prime
rs1002521449 -- 21,483,167(+) AAAAA(C/T)AGGCA intron-variant, upstream-variant-2KB
rs1003898717 -- 21,483,454(+) ATCTT(C/T)AAATA intron-variant, upstream-variant-2KB
rs1004098337 -- 21,483,682(+) ATGTA(C/G)TTTAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNE Gene

Variant ID Type Subtype PubMed ID
dgv7475n100 CNV loss 25217958
esv2752289 CNV gain 17911159
esv2764150 CNV gain+loss 21179565
esv3619963 CNV loss 21293372
esv3619964 CNV loss 21293372
nsv466297 CNV gain 19166990
nsv525510 CNV gain 19592680
nsv613758 CNV gain 21841781
nsv613759 CNV loss 21841781

Variation tolerance for IFNE Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNE Gene

Human Gene Mutation Database (HGMD)
IFNE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNE Gene

Disorders for IFNE Gene

Relevant External Links for IFNE

Genetic Association Database (GAD)
IFNE
Human Genome Epidemiology (HuGE) Navigator
IFNE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNE

No disorders were found for IFNE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNE Gene

Publications for IFNE Gene

  1. Purification of recombinant human interferon-epsilon and oligonucleotide microarray analysis of interferon-epsilon-regulated genes. (PMID: 17287131) Peng F.W. … Hou Y.D. (Protein Expr. Purif. 2007) 2 3 22 64
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 46 64
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 64
  4. Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study. (PMID: 20601674) Melton P.E. … Almasy L. (Hum. Mol. Genet. 2010) 3 46 64
  5. Interferons, interferon-like cytokines, and their receptors. (PMID: 15546383) Pestka S. … Walter M.R. (Immunol. Rev. 2004) 2 3 64

Products for IFNE Gene

Sources for IFNE Gene

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