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IFNE Gene

protein-coding   GIFtS: 47
GCID: GC09M021480

Interferon, Epsilon

  See IFNE-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Epsilon1 2     IFN-E2
Interferon Epsilon-12 3     PRO6552
IFN-epsilon2 3     Interferon Epsilon2
IFNE12 3     Interferon Epsilon 12
IFNT12 5     Interferon Tau-12
INFE12 5     interferon-epsilon2

External Ids:    HGNC: 181631   Entrez Gene: 3383762   Ensembl: ENSG000001849957   OMIM: 6152235   UniProtKB: Q86WN23   

Export aliases for IFNE gene to outside databases

Previous GC identifers: GC09M021470 GC09M021444


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFNE Gene:
IFNE (interferon, epsilon) is a protein-coding gene. Diseases associated with IFNE include dengue hemorrhagic fever, and cutaneous malignant melanoma. GO annotations related to this gene include cytokine receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNE_HUMAN, Q86WN2
Function: Type I interferon required for maintaining basal levels of IFN-regulated genes, including
2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection
against viral and bacterial genital infections (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the IFNE gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   HNF-3beta   Tal-1beta   Evi-1   HEN1   Cart-1   Sox9   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNE promoter sequence
   Search Chromatin IP Primers for IFNE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21.3   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p21.1

IFNE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNE gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021480:  view genomic region     (about GC identifiers)

Start:
21,480,838 bp from pter      End:
21,482,312 bp from pter
Size:
1,475 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IFNE_HUMAN, Q86WN2 (See protein sequence)
Recommended Name: Interferon epsilon precursor  
Size: 208 amino acids; 24414 Da
Developmental stage: Highly expressed in endometrial epithelial cells in proliferative phase of the menstrual
cycle. Levels decrease approximately 10-fold in the secretory phase. Virtually undetectable in samples from
postmenopausal women

Explore the universe of human proteins at neXtProt for IFNE: NX_Q86WN2

Explore proteomics data for IFNE at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn95, Asn104

  • See IFNE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_795372.1  
    ENSEMBL proteins: 
     ENSP00000418018  

    IFNE Human Recombinant Protein Products:

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    Novus Biologicals IFNE Protein
    Novus Biologicals IFNE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IFNE 

    IFNE Antibody Products:

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    Search for Antibodies for IFNE at Abcam
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    Search LSBio for Antibodies for IFNE

    IFNE Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IFNE 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR000471 Interferon_alpha/beta/delta
     IPR009079 4_helix_cytokine-like_core

    Graphical View of Domain Structure for InterPro Entry Q86WN2

    ProtoNet protein and cluster: Q86WN2

    1 Blocks protein domain: IPB000471 Interferon alpha

    UniProtKB/Swiss-Prot: IFNE_HUMAN, Q86WN2
    Similarity: Belongs to the alpha/beta interferon family


    Find genes that share domains with IFNE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFNE_HUMAN, Q86WN2
    Function: Type I interferon required for maintaining basal levels of IFN-regulated genes, including
    2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection
    against viral and bacterial genital infections (By similarity)
    Induction: By estrogens (Probable)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IBA--
    GO:0005126cytokine receptor binding ----
    GO:0005132type I interferon receptor binding IBA--
         
    Find genes that share ontologies with IFNE           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ifne):
     hematopoietic system  immune system  integument  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with IFNE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IFNE: Ifnetm1.2Pjh Ifnetm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFNE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFNE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNE

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFNE:
    hsa-mir-7-5p (MIRT025898)

    Block miRNA regulation of human, mouse, rat IFNE using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFNE
    SwitchGear 3'UTR luciferase reporter plasmidIFNE 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IFNE
    Predesigned siRNA for gene silencing in human, mouse, rat IFNE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFNE

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    OriGene clones in human, mouse for IFNE (see all 5)
    OriGene ORF clones in mouse, rat for IFNE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNE (NM_176891)
    Sino Biological Human cDNA Clone for IFNE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNE

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IFNE 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFNE_HUMAN, Q86WN2: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IBA--

    Find genes that share ontologies with IFNE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFNE About    
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I-like receptor signaling pathway0.47
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    3Jak-STAT signaling pathway
    Jak-STAT signaling pathway


    Find genes that share SuperPaths with IFNE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for IFNE
        all-trans-Retinoic Acid Mediated Apoptosis



    3 Kegg Pathways  (Kegg details for IFNE):
        Cytokine-cytokine receptor interaction
    RIG-I-like receptor signaling pathway
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNE: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IFNE

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for IFNE (ENSP000004180184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFNAR1ENSP000002701394STRING: ENSP00000270139
    IFNAR2ENSP000003439574STRING: ENSP00000343957
    TUBA1AENSP000003010714STRING: ENSP00000301071
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002250adaptive immune response IBA--
    GO:0002286T cell activation involved in immune response IBA--
    GO:0002323natural killer cell activation involved in immune response IBA--
    GO:0006952defense response ----
    GO:0006959humoral immune response IBA--

    Find genes that share ontologies with IFNE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFNE



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFNE gene: 
    NM_176891.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000448696(uc003zpg.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat IFNE using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFNE
    SwitchGear 3'UTR luciferase reporter plasmidIFNE 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFNE
    Predesigned siRNA for gene silencing in human, mouse, rat IFNE
    Clone
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    OriGene clones in human, mouse for IFNE (see all 5)
    OriGene ORF clones in mouse, rat for IFNE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNE (NM_176891)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNE
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFNE
      QuantiTect SYBR Green Assays in human, mouse, rat IFNE
      QuantiFast Probe-based Assays in human, mouse, rat IFNE

    4 AceView cDNA sequences:

    AY190045 NM_176891 BQ009304 AY358570 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFNE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IFNE Expression
    About this image

    IFNE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFNE Protein Expression

    UniProtKB/Swiss-Prot: IFNE_HUMAN, Q86WN2
    Tissue specificity: Endometrium-specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNE: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFNE
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    QuantiFast Probe-based Assays in human, mouse, rat IFNE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFNE gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifne1 , 5 interferon epsilon1, 5 71.81(n)1
    59.57(a)1
      4 (42.04 cM)5
    2304051  NM_177348.21  NP_796322.11 
     888795385 
    chicken
    (Gallus gallus)
    Aves LOC1017502451 interferon kappa-like 53.18(n)
    35.39(a)
      101750245  XM_004949132.1  XP_004949189.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    28(a)
    27(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    2(61644933-61645472)
    2(61637693-61638268)


    ENSEMBL Gene Tree for IFNE (if available)
    TreeFam Gene Tree for IFNE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFNE gene
    IFNA72  IFNA22  IFNA42  IFNA142  IFNA52  IFNK2  IFNA12  IFNA212  
    IFNA172  IFNA62  IFNB12  IFNA132  IFNW12  IFNA162  IFNA102  IFNA82  
    18 SIMAP similar genes for IFNE using alignment to 1 protein entry:     IFNE_HUMAN:
    IFNA    IFNA2    IFNA13    IFNA2B    IFNA1    IFNA10
    IFNA4    IFNA6    IFNA8    IFNW1    IFNB1    IFNA14
    IFNA16    IFNA17    IFNA21    IFNA7    IFNA5    IFNK

    Find genes that share paralogs with IFNE           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IFNE
    PGOHUM00000235986


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for IFNE    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11254881,2,4
    ----see VAR_0496392 mis40--------

    HapMap Linkage Disequilibrium report for IFNE (21480838 - 21482312 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for IFNE:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv892724CNV Gain21882294
    nsv525510CNV Gain19592680
    nsv466297CNV Gain19166990
    nsv892740CNV Gain21882294
    esv2752289CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNE
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615223    OMIM disorders: --

    2 diseases for IFNE:    
    About MalaCards
    dengue hemorrhagic fever    cutaneous malignant melanoma

    1 disease from the University of Copenhagen DISEASES database for IFNE:
    Letterer-Siwe disease

    Find genes that share disorders with IFNE           About GenesLikeMe

    Genetic Association Database (GAD): IFNE
    Human Genome Epidemiology (HuGE) Navigator: IFNE (4 documents)

    Export disorders for IFNE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFNE gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with IFNE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification of recombinant human interferon-epsilon and oligonucleotide microarray analysis of interferon-epsilon-regulated genes. (PubMed id 17287131)1, 3, 9 Peng F.W....Hou Y.D. (Protein Expr. Purif. 2007)
    2. Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study. (PubMed id 20601674)1, 4 Melton P.E....Almasy L. (Hum. Mol. Genet. 2010)
    3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    4. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (Fam. Cancer 2010)
    5. Characterization of the type I interferon locus and identification of novel genes. (PubMed id 15233997)1, 2 Hardy M.P.... Hertzog P.J. (Genomics 2004)
    6. Interferons, interferon-like cytokines, and their receptors. (PubMed id 15546383)1, 3 Pestka S....Walter M.R. (Immunol. Rev. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Interferon-epsilon protects the female reproductive tract from viral and bacterial infection. (PubMed id 23449591)2 Fung K.Y.... Hertzog P.J. (Science 2013)
    9. Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-I/ expression. (PubMed id 23851686)1 Matsumiya T....Stafforini D.M. (J. Immunol. 2013)
    10. THOC5: a novel gene involved in HDL-cholesterol metabolism. (PubMed id 24023261)1 Keller M....Kovacs P. (J. Lipid Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 338376 HGNC: 18163 AceView: IFNE1 Ensembl:ENSG00000184995 euGenes: HUgn338376
    ECgene: IFNE Kegg: 338376 H-InvDB: IFNE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFNE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFNE gene:
    Search GeneIP for patents involving IFNE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IFNE  
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     OriGene Custom Antibody Services for IFNE   OriGene Custom Protein Services for IFNE  

     
     
     Block miRNA regulation of human, mouse, rat IFNE using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IFNE
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNE Predesigned siRNA for gene silencing in human, mouse, rat IFNE
     QuantiFast Probe-based Assays in human, mouse, rat IFNE QuantiTect SYBR Green Assays in human, mouse, rat IFNE
     PCR Arrays including human, mouse, rat IFNE Search Chromatin IP Primers for IFNE
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFNE  Search GeneGlobe Interaction Network for IFNE
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     Search Tocris compounds for IFNE
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Search for Antibodies for IFNE at Abcam
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     Browse Proteins at Cloud-Clone Corp.
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     Browse ESI BIO Cell Lines and PureStem Progenitors for IFNE
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNE
     SwitchGear 3'UTR luciferase reporter plasmids for IFNE
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     Search ThermoFisher Antibodies for IFNE
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNE
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFNE
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     Search LSBio for Antibodies for IFNE
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     Search Addgene for plasmids for IFNE
      Search eBioscience for proteins for IFNE
      Search eBioscience for elisas for IFNE
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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