IFNE Gene
protein-coding GIFtS : 48
GCID: GC09 M021480
interferon, epsilon
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Aliasesfor IFNE gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Interferon, Epsilon 1 2 PRO6552 IFNE11 2 3 Interferon Epsilon2 Interferon Epsilon-12 3 Interferon Epsilon 12 IFN-Epsilon1 Interferon Tau-12 IFN-E2 Interferon-Epsilon1 IFNT12
Export aliases for IFNE gene to outside databases Previous GC identifers: GC09M021470 GC09M021444
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Summariesfor IFNE gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor IFNE gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008413.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IFNE gene promoter: POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 HNF-3beta Tal-1beta Evi-1 HEN1 Cart-1 Sox9 ITF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for IFNE Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNE
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9p21.3 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p21.1 IFNE Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M021480: view genomic region
(about GC identifiers )
Start:
21,480,838 bp from pter
End:
21,482,312 bp from pter
Size:
1,475 bases
Orientation:
minus strand
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Proteinsfor IFNE gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: IFNE_HUMAN, Q86WN2 (See
protein sequence )Recommended Name: Interferon epsilon precursor Size : 208 amino acids; 24414 Da
Subcellular location : Secreted (Potential)Explore the universe of human proteins at neXtProt for IFNE: NX_Q86WN2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q86WN2 IFNE Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_795372.1 ENSEMBL proteins: ENSP00000418018 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005615 extracellular space
IEA --
IFNE for ontologies About GeneDecksing IFNE Antibody Products: Assay Products for IFNE:
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Protein
Domains / Familiesfor IFNE gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
IFNE for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q86WN2 ProtoNet protein and cluster: Q86WN2
1 Blocks protein family : IPB000471 Interferon alpha UniProtKB/Swiss-Prot: IFNE_HUMAN, Q86WN2 Similarity : Belongs to the alpha/beta interferon family
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Functionfor IFNE gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IFNE (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IFNEOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IFNE (NM_176891 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNE Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IFNE
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNE
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005125 cytokine activity
IEA -- GO:0005126 cytokine receptor binding
IEA --
IFNE for ontologies About GeneDecksing Animal Models: Mouse knock-out Ifne tm1Lex for IFNE 1 MGI phenotypic allele for Ifne (no phenotypes)
IFNE for phenotypes About GeneDecksing
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Pathways & Interactionsfor IFNE gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Jak-STAT signaling pathway 2 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 3 PEDF Induced Signaling
Pathway sources See GeneCards unified pathways Show all pathways 3
Kegg Pathways (Kegg details for IFNE) :
IFNE for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNE STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)3 Interacting proteins for IFNE (ENSP00000418018 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
IFNE for ontologies About GeneDecksing
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Drugs & Compoundsfor IFNE gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for IFNE Search CenterWatch for drugs/clinical trials and news about IFNE
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Transcriptsfor IFNE gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for IFNE gene: NM_176891.4 Unigene Cluster for IFNE:
Interferon, epsilon Hs.682604 Unigene Representative Sequence: AY358570 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000448696 (uc003zpg.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IFNE (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IFNEOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IFNE (NM_176891 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNE Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IFNE
Additional cDNA sequence: AY190045.1 AY358570.1 BC100871.2 BC100872.2 BC100873.1
1 DOTS entry : DT.97819190
4 AceView cDNA sequences :
NM_176891 AY190045 BQ009304 AY358570 GeneLoc Exon Structure
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Expression for IFNE gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section IFNE expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image IFNE expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See IFNE Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IFNE SOURCE GeneReport for Unigene cluster: Hs.682604 UniProtKB/Swiss-Prot: IFNE_HUMAN, Q86WN2 Tissue specificity : Expressed in prostate cancer cell line PC-3, amnion-derived WISH cells, melanoma cell lineSK-MEL-28, cell line Daudi and very weakly in MCF-7 human breast cancer cells. Not detected in cell lines Namalwa (Burkitt's lymphoma) and Jurkat (T-cell) SABiosciences Expression via Pathway-Focused PCR Arrays including IFNE : Interferons & Receptors in human mouse rat Type I Interferon Response in human mouse rat Inflammatory Response & Autoimmunity 384HT in human mouse rat
Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IFNEBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat IFNE QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IFNE QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IFNE In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNE
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Orthologsfor IFNE gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for IFNE gene from 3/7 species (see all 7 ) About this table
ENSEMBL Gene Tree for IFNE (if available)TreeFam Gene Tree for IFNE (if available)
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Paralogsfor IFNE gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for IFNE gene IFNA7 2 IFNA2 2 IFNA4 2 IFNA14 2 IFNK 2 IFNA5 2 IFNA1 2 IFNA21 2 IFNA17 2 IFNA6 2 IFNB1 2 IFNA13 2 IFNW1 2 IFNA10 2 IFNA16 2 IFNA8 2 18 SIMAP similar genes for IFNE using alignment to 1 protein entry: IFNE_HUMAN :IFNA IFNA2 IFNA13 IFNA2B IFNA1 IFNA10 IFNA4 IFNA6 IFNA8 IFNW1 IFNB1 IFNA14 IFNA16 IFNA17 IFNA21 IFNA7 IFNA5 IFNK
IFNE for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for IFNE PGOHUM00000235986
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Genomic Variantsfor IFNE gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for IFNE (21480838 - 21482312 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for IFNE 1 CNV : 8623
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IFNE
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Disorders
/ Diseasesfor IFNE gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IFNE for disorders About GeneDecksing 10 diseases for IFNE : About MalaCards letterer-siwe disease dengue hemorrhagic fever hemorrhagic fever burkitt's lymphoma cervical cancer cervicitis prostate cancer breast cancer prostatitis melanoma 1 disease from the University of Copenhagen DISEASES database for IFNE :Letterer-Siwe disease Human Genome Epidemiology (HuGE) Navigator: IFNE (4 documents) Export disorders for IFNE gene to outside databases
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Publicationsfor IFNE gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IFNE gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with IFNE) Utopia : connect your pdf to the dynamic world of online information
Purification of recombinant human interferon-epsilon and oligonucleotide microarray analysis of interferon-epsilon-regulated genes. (PubMed id 17287131) 1 , 3, 9 Peng F.W....Hou Y.D. (2007) Characterization of the type I interferon locus and identification of novel genes. (PubMed id 15233997) 1 , 2 Hardy M.P.... Hertzog P.J. (2004) Interferons, interferon-like cytokines, and their receptors. (PubMed id 15546383) 1 , 3 Pestka S....Walter M.R. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) The small molecule inhibitor PR-619 of deubiquitinatin g enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. (PubMed id 22565157) 1 Seiberlich V....Richter-Landsberg C. (2012) Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study. (PubMed id 20601674) 1 Melton P.E....Almasy L. (2010) Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308) 1 Silva L.K....Teixeira M.G. (2010) Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843) 1 Yang X.R....Goldstein A.M. (2010) Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. (PubMed id 18362232) 1 Schunkert H....Samani N.J. (2008) [Anti-HIV effects of IFN-tau in human macrophages: role of cellular antiviral factors and interleukin-6] (PubMed id 18842358) 1 Maneglier B....Clayette P. (2008)
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External Searches for IFNE gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IFNE gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IFNE gene
(According to HUGE )
About This Section --
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Specialized Databases showing IFNE gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for IFNE Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for IFNE gene: Search GeneIP for patents involving IFNE GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IFNE gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for IFNE OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for IFNE OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IFNE OriGene Protein Over-expression Lysate for IFNE Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for IFNE Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IFNE OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IFNE Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for IFNE OriGene Custom Protein Services for IFNE OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNE QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IFNE QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNE QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat IFNE QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IFNE QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IFNE
Search Tocris compounds for IFNE
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNE
Search ThermoFisher Antibodies for IFNE
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IFNE
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