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Aliases for IFNE Gene

Aliases for IFNE Gene

  • Interferon, Epsilon 2 3
  • Interferon Epsilon-1 3 4
  • IFN-Epsilon 3 4
  • IFNE1 3 4
  • Interferon Epsilon 1 3
  • Interferon-Epsilon 3
  • Interferon Tau-1 3
  • PRO655 3
  • IFNT1 3
  • INFE1 3
  • IFN-E 3

External Ids for IFNE Gene

Previous GeneCards Identifiers for IFNE Gene

  • GC09M021470
  • GC09M021444

Summaries for IFNE Gene

GeneCards Summary for IFNE Gene

IFNE (Interferon, Epsilon) is a Protein Coding gene. Diseases associated with IFNE include west nile fever. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA1.

UniProtKB/Swiss-Prot for IFNE Gene

  • Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2-5-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNE Gene

Genomics for IFNE Gene

Genomic Location for IFNE Gene

Chromosome:
9
Start:
21,480,839 bp from pter
End:
21,482,313 bp from pter
Size:
1,475 bases
Orientation:
Minus strand

Genomic View for IFNE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNE Gene

Proteins for IFNE Gene

  • Protein details for IFNE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WN2-IFNE_HUMAN
    Recommended name:
    Interferon epsilon
    Protein Accession:
    Q86WN2

    Protein attributes for IFNE Gene

    Size:
    208 amino acids
    Molecular mass:
    24414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNE Gene

Proteomics data for IFNE Gene at MOPED

Post-translational modifications for IFNE Gene

  • Glycosylation at Asn 95 and Asn 104
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNE Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IFNE Gene

Domains & Families for IFNE Gene

Suggested Antigen Peptide Sequences for IFNE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WN2

UniProtKB/Swiss-Prot:

IFNE_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNE: view

No data available for Gene Families for IFNE Gene

Function for IFNE Gene

Molecular function for IFNE Gene

UniProtKB/Swiss-Prot Function:
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2-5-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).
UniProtKB/Swiss-Prot Induction:
By estrogens.

Gene Ontology (GO) - Molecular Function for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNE: view
genes like me logo Genes that share phenotypes with IFNE: view

Animal Models for IFNE Gene

MGI Knock Outs for IFNE:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNE

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IFNE Gene

Localization for IFNE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNE Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNE Gene COMPARTMENTS Subcellular localization image for IFNE gene
Compartment Confidence
extracellular 3
cytosol 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNE: view

Pathways & Interactions for IFNE Gene

genes like me logo Genes that share pathways with IFNE: view

Pathways by source for IFNE Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat

Interacting Proteins for IFNE Gene

Gene Ontology (GO) - Biological Process for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNE: view

No data available for SIGNOR curated interactions for IFNE Gene

Drugs & Compounds for IFNE Gene

No Compound Related Data Available

Transcripts for IFNE Gene

mRNA/cDNA for IFNE Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNE Gene

Interferon, epsilon:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNE Gene

No ASD Table

Relevant External Links for IFNE Gene

GeneLoc Exon Structure for
IFNE
ECgene alternative splicing isoforms for
IFNE

Expression for IFNE Gene

mRNA expression in normal human tissues for IFNE Gene

mRNA differential expression in normal tissues according to GTEx for IFNE Gene

This gene is overexpressed in Esophagus - Mucosa (x6.0) and Bladder (x5.6).

SOURCE GeneReport for Unigene cluster for IFNE Gene Hs.682604

mRNA Expression by UniProt/SwissProt for IFNE Gene

Q86WN2-IFNE_HUMAN
Tissue specificity: Endometrium-specific.
genes like me logo Genes that share expression patterns with IFNE: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IFNE Gene

Orthologs for IFNE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFNE 35
  • 83.86 (n)
  • 77.89 (a)
IFNE 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifne 35
  • 71.81 (n)
  • 59.57 (a)
Ifne 16
Ifne 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IFNE 35
  • 99.2 (n)
  • 98.56 (a)
IFNE 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifne 35
  • 72.63 (n)
  • 62.01 (a)
dog
(Canis familiaris)
Mammalia IFNE 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia IFN4 36
  • 38 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC101750245 35
  • 53.18 (n)
  • 35.39 (a)
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
Species with no ortholog for IFNE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNE Gene

ENSEMBL:
Gene Tree for IFNE (if available)
TreeFam:
Gene Tree for IFNE (if available)

Paralogs for IFNE Gene

(18) SIMAP similar genes for IFNE Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFNE Gene

genes like me logo Genes that share paralogs with IFNE: view

Variants for IFNE Gene

Sequence variations from dbSNP and Humsavar for IFNE Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_049639 -

Structural Variations from Database of Genomic Variants (DGV) for IFNE Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
esv2752289 CNV Gain 17911159
nsv466297 CNV Gain 19166990
nsv892740 CNV Gain 21882294
nsv525510 CNV Gain 19592680

Variation tolerance for IFNE Gene

Residual Variation Intolerance Score: 68.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNE Gene

HapMap Linkage Disequilibrium report
IFNE
Human Gene Mutation Database (HGMD)
IFNE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNE Gene

Disorders for IFNE Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNE Gene - From: DISEASES

Disorder Aliases PubMed IDs
west nile fever
- elite association
Search IFNE in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFNE

Genetic Association Database (GAD)
IFNE
Human Genome Epidemiology (HuGE) Navigator
IFNE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNE
genes like me logo Genes that share disorders with IFNE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNE Gene

Publications for IFNE Gene

  1. Purification of recombinant human interferon-epsilon and oligonucleotide microarray analysis of interferon-epsilon-regulated genes. (PMID: 17287131) Peng F.W. … Hou Y.D. (Protein Expr. Purif. 2007) 2 23 67
  2. Interferons, interferon-like cytokines, and their receptors. (PMID: 15546383) Pestka S. … Walter M.R. (Immunol. Rev. 2004) 2 67
  3. T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-I/ is a risk factor for the development of intracerebral hemorrhage. (PMID: 24055696) Kim S.K. … Kim H.S. (Hum. Immunol. 2014) 67
  4. Interferon-epsilon protects the female reproductive tract from viral and bacterial infection. (PMID: 23449591) Fung K.Y. … Hertzog P.J. (Science 2013) 67
  5. Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-I/ expression. (PMID: 23851686) Matsumiya T. … Stafforini D.M. (J. Immunol. 2013) 67

Products for IFNE Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNE
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFNE
    • Block miRNA regulation of IFNE using miScript Target Protectors

    Sources for IFNE Gene

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