Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IFNE Gene

Aliases for IFNE Gene

  • Interferon, Epsilon 2 3
  • Interferon Epsilon-1 3 4
  • IFN-Epsilon 3 4
  • IFNT1 3 6
  • INFE1 3 6
  • IFNE1 3 4
  • Interferon Epsilon 1 3
  • Interferon Epsilon 3
  • Interferon-Epsilon 3
  • Interferon Tau-1 3
  • PRO655 3
  • IFN-E 3

External Ids for IFNE Gene

Previous GeneCards Identifiers for IFNE Gene

  • GC09M021470
  • GC09M021444

Summaries for IFNE Gene

GeneCards Summary for IFNE Gene

IFNE (Interferon, Epsilon) is a Protein Coding gene. Diseases associated with IFNE include dengue hemorrhagic fever. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and cytokine receptor binding. An important paralog of this gene is IFNA1.

UniProtKB/Swiss-Prot for IFNE Gene

  • Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2-5-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNE Gene

Genomics for IFNE Gene

Genomic Location for IFNE Gene

Start:
21,480,839 bp from pter
End:
21,482,313 bp from pter
Size:
1,475 bases
Orientation:
Minus strand

Genomic View for IFNE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNE Gene

Proteins for IFNE Gene

  • Protein details for IFNE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WN2-IFNE_HUMAN
    Recommended name:
    Interferon epsilon
    Protein Accession:
    Q86WN2
    Secondary Accessions:

    Protein attributes for IFNE Gene

    Size:
    208 amino acids
    Molecular mass:
    24414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNE Gene

Proteomics data for IFNE Gene at MOPED

Post-translational modifications for IFNE Gene

  • Glycosylation at Asn95 and Asn104
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNE Gene

Domains for IFNE Gene

Suggested Antigen Peptide Sequences for IFNE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WN2

UniProtKB/Swiss-Prot:

IFNE_HUMAN :
  • Q86WN2
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNE: view

No data available for Gene Families for IFNE Gene

Function for IFNE Gene

Molecular function for IFNE Gene

UniProtKB/Swiss-Prot Function: Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2-5-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).
UniProtKB/Swiss-Prot Induction: By estrogens.

Gene Ontology (GO) - Molecular Function for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNE: view
genes like me logo Genes that share phenotypes with IFNE: view

Animal Models for IFNE Gene

MGI Knock Outs for IFNE:

miRNA for IFNE Gene

miRTarBase miRNAs that target IFNE

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IFNE Gene

Localization for IFNE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNE Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNE Gene COMPARTMENTS Subcellular localization image for IFNE gene
Compartment Confidence
extracellular 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNE: view

Pathways for IFNE Gene

genes like me logo Genes that share pathways with IFNE: view

Pathways by source for IFNE Gene

Interacting Proteins for IFNE Gene

Gene Ontology (GO) - Biological Process for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNE: view

Transcripts for IFNE Gene

mRNA/cDNA for IFNE Gene

(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNE Gene

Interferon, epsilon:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNE Gene

No ASD Table

Relevant External Links for IFNE Gene

GeneLoc Exon Structure for
IFNE
ECgene alternative splicing isoforms for
IFNE

Expression for IFNE Gene

mRNA expression in normal human tissues for IFNE Gene

mRNA differential expression in normal tissues according to GTEx for IFNE Gene

This gene is overexpressed in Esophagus - Mucosa (6.0) and Bladder (5.6).

SOURCE GeneReport for Unigene cluster for IFNE Gene Hs.682604

mRNA Expression by UniProt/SwissProt for IFNE Gene

Q86WN2-IFNE_HUMAN
Tissue specificity: Endometrium-specific.
genes like me logo Genes that share expressions with IFNE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for IFNE Gene

Orthologs for IFNE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNE 35
  • 99.2 (n)
  • 98.56 (a)
IFNE 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFNE 35
  • 83.86 (n)
  • 77.89 (a)
IFNE 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFNE 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifne 35
  • 71.81 (n)
  • 59.57 (a)
Ifne 16
Ifne 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia IFN4 36
  • 38 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifne 35
  • 72.63 (n)
  • 62.01 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 31 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
LOC101750245 35
  • 53.18 (n)
  • 35.39 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
Species with no ortholog for IFNE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNE Gene

ENSEMBL:
Gene Tree for IFNE (if available)
TreeFam:
Gene Tree for IFNE (if available)

Paralogs for IFNE Gene

Selected SIMAP similar genes for IFNE Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFNE Gene

genes like me logo Genes that share paralogs with IFNE: view

Variants for IFNE Gene

Sequence variations from dbSNP and Humsavar for IFNE Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_049639 -

Structural Variations from Database of Genomic Variants (DGV) for IFNE Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
esv2752289 CNV Gain 17911159
nsv466297 CNV Gain 19166990
nsv892740 CNV Gain 21882294
nsv525510 CNV Gain 19592680

Relevant External Links for IFNE Gene

HapMap Linkage Disequilibrium report
IFNE
Human Gene Mutation Database (HGMD)
IFNE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNE Gene

Disorders for IFNE Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for IFNE Gene including...

Search for IFNE Gene in MalaCards »

(1) University of Copenhagen DISEASES for IFNE Gene

Relevant External Links for IFNE

Genetic Association Database (GAD)
IFNE
Human Genome Epidemiology (HuGE) Navigator
IFNE
genes like me logo Genes that share disorders with IFNE: view

No data available for UniProtKB/Swiss-Prot for IFNE Gene

Publications for IFNE Gene

  1. Purification of recombinant human interferon-epsilon and oligonucleotide microarray analysis of interferon-epsilon-regulated genes. (PMID: 17287131) Peng F.W. … Hou Y.D. (Protein Expr. Purif. 2007) 2 3 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Characterization of the type I interferon locus and identification of novel genes. (PMID: 15233997) Hardy M.P. … Hertzog P.J. (Genomics 2004) 3 4
  4. Interferons, interferon-like cytokines, and their receptors. (PMID: 15546383) Pestka S. … Walter M.R. (Immunol. Rev. 2004) 2 3
  5. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 48

Products for IFNE Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat
    • Type I Interferon Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNE
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFNE
    • Block miRNA regulation of IFNE using miScript Target Protectors

    Sources for IFNE Gene

    Back to Top

    Content