Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IFNB1 Gene

Aliases for IFNB1 Gene

  • Interferon Beta 1 2 3 5
  • Interferon, Beta 1, Fibroblast 2 3
  • Fibroblast Interferon 3 4
  • IFN-Beta 3 4
  • IFNB 3 4
  • IFB 3 4
  • Interferon Beta 3
  • Interferon-Beta 3
  • IFF 3

External Ids for IFNB1 Gene

Previous HGNC Symbols for IFNB1 Gene

  • IFNB

Previous GeneCards Identifiers for IFNB1 Gene

  • GC09M021404
  • GC09M021278
  • GC09M021067
  • GC09M021040

Summaries for IFNB1 Gene

Entrez Gene Summary for IFNB1 Gene

  • This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]

GeneCards Summary for IFNB1 Gene

IFNB1 (Interferon Beta 1) is a Protein Coding gene. Diseases associated with IFNB1 include Relapsing-Remitting Multiple Sclerosis and Secondary Progressive Multiple Sclerosis. Among its related pathways are PEDF Induced Signaling and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNB1 Gene

  • Has antiviral, antibacterial and anticancer activities.

Gene Wiki entry for IFNB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNB1 Gene

Genomics for IFNB1 Gene

Regulatory Elements for IFNB1 Gene

Enhancers for IFNB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IFNB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNB1 Gene

Chromosome:
9
Start:
21,077,105 bp from pter
End:
21,077,963 bp from pter
Size:
859 bases
Orientation:
Minus strand

Genomic View for IFNB1 Gene

Genes around IFNB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNB1 Gene

Proteins for IFNB1 Gene

  • Protein details for IFNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01574-IFNB_HUMAN
    Recommended name:
    Interferon beta
    Protein Accession:
    P01574
    Secondary Accessions:
    • Q5VWC9

    Protein attributes for IFNB1 Gene

    Size:
    187 amino acids
    Molecular mass:
    22294 Da
    Quaternary structure:
    • Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.

    Three dimensional structures from OCA and Proteopedia for IFNB1 Gene

neXtProt entry for IFNB1 Gene

Post-translational modifications for IFNB1 Gene

  • Glycosylation at Asn 101
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IFNB1 Gene

Domains & Families for IFNB1 Gene

Gene Families for IFNB1 Gene

Suggested Antigen Peptide Sequences for IFNB1 Gene

Graphical View of Domain Structure for InterPro Entry

P01574

UniProtKB/Swiss-Prot:

IFNB_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNB1: view

Function for IFNB1 Gene

Molecular function for IFNB1 Gene

GENATLAS Biochemistry:
interferon type I,beta 1,fibroblast,22.3kDa
UniProtKB/Swiss-Prot Function:
Has antiviral, antibacterial and anticancer activities.

Gene Ontology (GO) - Molecular Function for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IDA 19008854
GO:0005132 type I interferon receptor binding IEA,NAS 2414376
GO:0008811 chloramphenicol O-acetyltransferase activity IMP 19176627
genes like me logo Genes that share ontologies with IFNB1: view
genes like me logo Genes that share phenotypes with IFNB1: view

Animal Models for IFNB1 Gene

MGI Knock Outs for IFNB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IFNB1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNB1 Gene

Localization for IFNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNB1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNB1 Gene COMPARTMENTS Subcellular localization image for IFNB1 gene
Compartment Confidence
extracellular 5
cytosol 2
endosome 2
nucleus 2
plasma membrane 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with IFNB1: view

Pathways & Interactions for IFNB1 Gene

genes like me logo Genes that share pathways with IFNB1: view

SIGNOR curated interactions for IFNB1 Gene

Activates:

Gene Ontology (GO) - Biological Process for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002312 B cell activation involved in immune response IMP 12932356
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006959 humoral immune response IEA,IBA --
genes like me logo Genes that share ontologies with IFNB1: view

Drugs & Compounds for IFNB1 Gene

(72) Drugs for IFNB1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beta-D-Glucose Experimental Pharma Target 0

(63) Additional Compounds for IFNB1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
genes like me logo Genes that share compounds with IFNB1: view

Transcripts for IFNB1 Gene

mRNA/cDNA for IFNB1 Gene

(1) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IFNB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNB1 Gene

No ASD Table

Relevant External Links for IFNB1 Gene

GeneLoc Exon Structure for
IFNB1
ECgene alternative splicing isoforms for
IFNB1

Expression for IFNB1 Gene

mRNA expression in normal human tissues for IFNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of IFNB1 Gene:

IFNB1

SOURCE GeneReport for Unigene cluster for IFNB1 Gene:

Hs.93177
genes like me logo Genes that share expression patterns with IFNB1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IFNB1 Gene

Orthologs for IFNB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNB1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IFNB1 34
  • 75.27 (n)
  • 60.22 (a)
IFNB1 35
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifnb1 34
  • 67.4 (n)
  • 50.55 (a)
Ifnb1 16
Ifnb1 35
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IFNB1 34
  • 98.75 (n)
  • 97.33 (a)
IFNB1 35
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifnb1 34
  • 67.75 (n)
  • 50 (a)
cow
(Bos Taurus)
Mammalia -- 35
  • 55 (a)
OneToMany
IFNB1 35
  • 56 (a)
OneToMany
IFNB2 35
  • 60 (a)
OneToMany
IFNB3 35
  • 56 (a)
OneToMany
IL6 35
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia IFN1 35
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFN5 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 27 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 23 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
Species where no ortholog for IFNB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNB1 Gene

ENSEMBL:
Gene Tree for IFNB1 (if available)
TreeFam:
Gene Tree for IFNB1 (if available)

Paralogs for IFNB1 Gene

(18) SIMAP similar genes for IFNB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IFNB1: view

Variants for IFNB1 Gene

Sequence variations from dbSNP and Humsavar for IFNB1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_004016 -
VAR_036330 A breast cancer sample
rs9333358 -- 21,078,953(-) GAACC(A/G)GGAAG upstream-variant-2KB
rs118091685 -- 21,076,712(+) AATAA(A/C)GTGGG downstream-variant-500B
rs1051922 -- 21,077,717(-) GAATA(C/T)TGCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IFNB1 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
nsv1017312 CNV gain 25217958
nsv1161847 CNV deletion 26073780
nsv466294 CNV loss 19166990
nsv613752 CNV loss 21841781
nsv613753 CNV loss 21841781

Variation tolerance for IFNB1 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNB1 Gene

Human Gene Mutation Database (HGMD)
IFNB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNB1 Gene

Disorders for IFNB1 Gene

MalaCards: The human disease database

(44) MalaCards diseases for IFNB1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
relapsing-remitting multiple sclerosis
  • relapsing-remitting ms
secondary progressive multiple sclerosis
  • secondary-progressive ms
primary progressive multiple sclerosis
  • ppms
newcastle disease
  • newcastle disease [ambiguous]
demyelinating disease
  • demyelinating disorder
- elite association - COSMIC cancer census association via MalaCards
Search IFNB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFNB1

Genetic Association Database (GAD)
IFNB1
Human Genome Epidemiology (HuGE) Navigator
IFNB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNB1
genes like me logo Genes that share disorders with IFNB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNB1 Gene

Publications for IFNB1 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 65
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 46 65
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 65
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  5. IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis. (PMID: 19201909) Khouri R. … Van Weyenbergh J. (J. Immunol. 2009) 3 22 65

Products for IFNB1 Gene

  • Addgene plasmids for IFNB1

Sources for IFNB1 Gene

Content
Loading form....