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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFNB1 Gene

protein-coding GIFtS: 65
GCID: GC09M021077

interferon, beta 1, fibroblast

(Previous symbol: IFNB)

Explore 165 diseases affiliated with
IFNB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interferon, Beta 1, Fibroblast¹ ²		Fibroblast Interferon² ³
IFB¹ ² ³		IFN-Beta¹
IFNB¹ ² ³		Interferon Beta²
IFF¹ ²

External Ids:	HGNC: 5434¹	Entrez Gene: 3456²	Ensembl: ENSG00000171855⁷	OMIM: 147640⁵	UniProtKB: P01574³

Export aliases for IFNB1 gene to outside databases

Previous GC identifers: GC09M021404 GC09M021278 GC09M021067 GC09M021040

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574

Function: Has antiviral, antibacterial and anticancer activities

Gene Wiki entry for IFNB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFNB1 gene promoter:
STAT1 AP-1 ATF-2 Evi-1 POU2F1 POU2F1a IRF-7A c-Jun MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFNB1 promoter sequence

Search SABiosciences Chromatin IP Primers for IFNB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22

IFNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNB1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M021077: view genomic region (about GC identifiers)

Start:	21,077,104 bp from pter	End:	21,077,943 bp from pter
Size:	840 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574 (See protein sequence)

Recommended Name: Interferon beta precursor

Size: 187 amino acids; 22294 Da

Subunit: Monomer

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for IFNB1:

1AU1 (3D)

Explore the universe of human proteins at neXtProt for IFNB1: NX_P01574

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01574

IFNB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002167.1

ENSEMBL proteins:

ENSP00000369581

Reactome Protein details: P01574
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant IFNB1 Protein
	R&D Systems Recombinant & Natural Proteins for IFNB1 (IFN-beta)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IFNB1 OriGene Custom Protein Services for IFNB1
	GenScript Custom Purified and Recombinant Proteins Services for IFNB1
	Novus Biologicals IFNB1 Proteins Novus Biologicals IFNB1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IFNB1
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

IFNB1 for ontologies About GeneDecksing

IFNB1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IFNB1
	R&D Systems Antibodies for IFNB1 (IFN-beta)
	OriGene Antibodies: IFNB1 OriGene Custom Antibody Services for IFNB1
	GenScript Custom Superior Antibodies Services for IFNB1
	Novus Biologicals IFNB1 Antibodies
	Abcam antibodies for IFNB1
	Browse Antibodies at Uscn
	ThermoFisher Antibody for IFNB1

Assay Products for IFNB1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IFNB1 (IFN-beta)
	GenScript Custom Assay Services for IFNB1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFNB1 for domains About GeneDecksing

4 InterPro domains/families:

IPR012351 4_helix_cytokine_core

IPR000471 Interferon_alpha/beta/delta

IPR009079 4_helix_cytokine-like_core

IPR015588 Interferon_beta

Graphical View of Domain Structure for InterPro Entry P01574

ProtoNet protein and cluster: P01574

1 Blocks protein family: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574

Similarity: Belongs to the alpha/beta interferon family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574

Function: Has antiviral, antibacterial and anticancer activities

Genatlas biochemistry entry for IFNB1:

interferon type I,beta 1,fibroblast,22.3kDa

miRNA Products:		miRTarBase miRNAs that target IFNB1: hsa-mir-145 (MIRT004616), hsa-let-7b (MIRT004614), hsa-mir-26a (MIRT004615), hsa-mir-34a (MIRT004617)

		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNB1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFNB1
		SwitchGear 3'UTR luciferase reporter plasmid: IFNB1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNB1 (see all 7) OriGene shRNA RFP: IFNB1 OriGene siRNA: IFNB1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNB1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IFNB1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNB1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNB1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNB1 (NM_002176)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNB1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNB1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IFNB1
		Search LifeMap BioReagents cell lines for IFNB1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNB1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003714	transcription corepressor activity	IDA	16873258
GO:0005125	cytokine activity	IEA	--
GO:0005132	interferon-alpha/beta receptor binding	NAS	2414376

IFNB1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Ifnb1^tm1Tl for IFNB1
     9 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Ifnb1):

cellular	hematopoietic system	homeostasis/metabolism	immune system	nervous system
no phenotypic analysis	normal	skeleton	tumorigenesis

IFNB1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of IFNA signaling

Regulation of IFNA signaling	1.00	TRAF6 mediated IRF7 activation	0.33
Immune response_IFN alpha/beta signaling pathway	0.71	Cytokine Network	0.28
Immune response IFN alpha/beta signaling pathway	0.71	TRAF3-dependent IRF activation pathway	0.03
Expression of Interferon-alpha and beta	0.52

Toll-like receptor signaling pathway

	Toll-like receptor signaling pathway	1.00			Toll-Like receptor Signaling Pathways	0.51
	Toll-like receptor signaling pathway	0.97			Chagas disease (American trypanosomiasis)	0.31

Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway

Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway

1.00

Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways

0.91

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Immune System

Immune System

1.00

Innate Immune System

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for IFNB1

	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Immune response IFN alpha/beta signaling pathway
	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

1 R&D Systems Pathway for IFNB1

Toll-Like receptor Signaling Pathways

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNB1

	Cytokine Network
	Interferon Pathway
	JAK-STAT Pathway
	all-trans-Retinoic Acid Mediated Apoptosis

3 GeneGo (Thomson Reuters) Pathways for IFNB1

	Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
	Immune response TLR signaling pathways
	Immune response IFN alpha/beta signaling pathway

5/7 BioSystems Pathways for IFNB1 (see all 7)

	EBV LMP1 signaling
	Type II interferon signaling (IFNG)
	Senescence and Autophagy
	Cytokines and Inflammatory Response
	Toll-like receptor signaling pathway

5/13 Reactome Pathways for IFNB1 (see all 13)

	Hemostasis
	Regulation of IFNA signaling
	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

5/12 Kegg Pathways (Kegg details for IFNB1) (see all 12):

	Cytokine-cytokine receptor interaction
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	Cytosolic DNA-sensing pathway

IFNB1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IFNB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for IFNB1 (P01574³ ENSP00000369581⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IFNAR2	P48551³, ENSP00000343957⁴	I2D: score=1 STRING: ENSP00000343957
IFNAR1	P17181³, ENSP00000270139⁴	I2D: score=1 STRING: ENSP00000270139
CREBBP	ENSP00000262367⁴	STRING: ENSP00000262367
EP300	ENSP00000263253⁴	STRING: ENSP00000263253
IFNA14	ENSP00000369571⁴	STRING: ENSP00000369571

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002250	adaptive immune response	IEA	--
GO:0006917	induction of apoptosis	IDA	11337497
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	NAS	10918594
GO:0006959	humoral immune response	IEA	--
GO:0007166	cell surface receptor signaling pathway	TAS	10640778

IFNB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IFNB1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNB1
UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574

Pharmaceutical: Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment

of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions

2 DrugBank Compounds for IFNB1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-D-Mannose	--	3458-28-4	target	--	17139284 17016423
Beta-D-Glucose	--	50-99-7	target	--	17139284 17016423

10/133 Novoseek chemical compound relationships for IFNB1 gene (see all 133) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
betaseron	91.4	36	12581490 (2), 10485260 (2), 16042224 (1), 17273808 (1) (see all 19)
rebif	91	20	12581490 (2), 16042224 (1), 17273808 (1), 10378715 (1) (see all 15)
avonex	90.9	21	10485260 (2), 16042224 (1), 16170498 (1), 17273808 (1) (see all 16)
2',5'-oligoadenylate	82	32	2121851 (3), 2395002 (2), 8103050 (1), 2086672 (1) (see all 24)
polyinosinic-polycytidylic acid	81.9	39	2177082 (4), 19452017 (3), 1666117 (3), 1602741 (2) (see all 23)
glatiramer acetate	81.2	114	14760948 (6), 11730946 (5), 17661794 (4), 19609087 (3) (see all 36)
ifn-alpha	80.1	44	20299237 (4), 14719113 (2), 12725866 (1), 16736505 (1) (see all 39)
poly(i-c)	79.8	40	19669308 (3), 19728309 (3), 17142768 (2), 14596815 (2) (see all 27)
edss	76.8	17	12446026 (1), 18353125 (1), 14669137 (1), 17439902 (1) (see all 15)
mezerein	76.2	77	8545104 (4), 7753561 (3), 1357650 (3), 7566979 (2) (see all 19)

Search CenterWatch for drugs/clinical trials and news about IFNB1 / IFNB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNB1 gene:

NM_002176.2

Unigene Cluster for IFNB1:

Interferon, beta 1, fibroblast

Hs.93177

Unigene Representative Sequence: M28622

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000380232(uc003zok.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNB1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFNB1
		SwitchGear 3'UTR luciferase reporter plasmid: IFNB1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNB1 (see all 7) OriGene shRNA RFP: IFNB1 OriGene siRNA: IFNB1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNB1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNB1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNB1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNB1 (NM_002176)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNB1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNB1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNB1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IFNB1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNB1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNB1

Additional cDNA sequence:

AB451323.1 AB451452.1 AB451491.1 BC069314.1 BC096150.3 BC096151.2 BC096152.2 BC096153.2

M17373.2 M25460.1 M28622.1 V00546.1 V00547.1

1 DOTS entry:

DT.455910

9 AceView cDNA sequences:

M28622 BC069314 V00546 NM_002176 V00547 R63093 M25460 M17373

R63139

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCAGTCTGC

About this image

IFNB1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IFNB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNB1

SOURCE GeneReport for Unigene cluster: Hs.93177

SABiosciences Expression via Pathway-Focused PCR Arrays including IFNB1 (see all 14):

HIV Host Response in human mouse rat

NFKB Signaling Targets in human mouse rat

Antiviral Response in human mouse rat

Angiogenic Growth Factors in human mouse rat

Interferons & Receptors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNB1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IFNB1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNB1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNB1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFNB1 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	--	28(a)	1 → many	Un(24396419-24396970)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 6)	--	28(a) 27(a) (see all 6)	many ↔ many many ↔ many (see all 6)	2(61644933-61645472) 2(61647787-61648344)
zebrafish (Danio rerio)	Actinopterygii	ifnphi3⁶ ifnphi2⁶	interferon phi 2	27(a) 22(a)	many ↔ many many ↔ many	3(22558521-22560658) 3(22565711-22572180)

ENSEMBL Gene Tree for IFNB1 (if available)
TreeFam Gene Tree for IFNB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IFNB1 gene

IFNA7² IFNA2² IFNA4² IFNE² IFNA14² IFNK² IFNA5² IFNA1²

IFNA21² IFNA17² IFNA6² IFNA13² IFNW1² IFNA10² IFNA16² IFNA8²

18 SIMAP similar genes for IFNB1 using alignment to 3 protein entries: IFNB_HUMAN (see all proteins):

IFNW1 IFNA16 IFNA10 IFNA17 IFNA21 IFNA4

IFNA IFNE IFNA8 IFNA14 IFNA1 IFNA13

IFNA5 IFNA7 IFNA2 IFNA6 IFNA2B IFNK

IFNB1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1364613^1,2	C,F,A,	--	21076679(-)	`AAAGAT/GTTTTA`	1	--	ds500¹		5		WA NA EA	362
rs1364612^1,2	C,F,A,H,	--	21076686(-)	`CTCCTC/GGAAAG`	1	--	ds500¹		12		NA NS EA WA	894
rs28368126^1,2	C,	--	21076693(-)	`ATACT-/TTGCTC`	1	--	ds500¹		0	--	--	--	--
rs144899244^1,2		--	21076701(+)	`GTATCC/GCCCAA`	1	--	ds500¹		0	--	--	--	--
rs118091685^1,2		--	21076711(+)	`AATAAC/AGTGGG`	1	--	ds500¹		1		NA	120
rs28368125^1,2	C,	--	21076738(-)	`GTCAG-/CTTTTG`	1	--	ds500¹		0	--	--	--	--
rs185448411^1,2		--	21076750(+)	`TATTCC/GTCTGG`	1	--	ds500¹		0	--	--	--	--
rs189528267^1,2		--	21076758(+)	`TGGCTA/CTTCCT`	1	--	ds500¹		0	--	--	--	--
rs28539988^1,2	C,F,H	--	21076883(+)	`CACAGC/AAGTTC`	1	--	ds500¹		4		NS NA	516
rs146766199^1,2		--	21076903(+)	`TTATTC/GCCCCA`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IFNB1 (21077104 - 21077943 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFNB1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IFNB1 for disorders           About GeneDecksing

OMIM gene information: 147640    OMIM disorders: --

20/165 diseases for IFNB1 (see all 165):    About MalaCards

tick-borne encephalitis primitive neuroectodermal tumor relapsing-remitting multiple sclerosis venezuelan equine encephalitis

chronic inflammatory demyelinating polyradiculoneuropathy diffuse large b-cell lymphoma progressive multifocal leukoencephalopathy parainfluenza virus type 3

severe combined immunodeficiency neuromyelitis optica molluscum contagiosum cerebral primitive neuroectodermal tumor

chronic mucocutaneous candidiasis polyradiculoneuropathy b-cell lymphomas neuroectodermal tumors

dengue hemorrhagic fever common wart multiple sclerosis malignant pleural mesothelioma

9 diseases from the University of Copenhagen DISEASES database for IFNB1:

Multiple sclerosis Optic neuritis Chronic inflammatory demyelinating polyradiculoneuropathy Progressive multifocal leukoencephalopathy

Hepatitis C Melanoma Hepatitis Malignant glioma

Neuromyelitis optica

10/94 Novoseek disease relationships for IFNB1 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
multiple sclerosis relapsing-remitting	90.6	89	18562504 (2), 19932513 (2), 19506220 (2), 11911803 (2) (see all 70)
multiple sclerosis	88.5	343	14607790 (7), 19604093 (3), 9686625 (3), 10570511 (3) (see all 99)
virus infection	73.9	114	12654014 (4), 15210742 (3), 10074115 (3), 10024886 (3) (see all 83)
secondary progressive multiple sclerosis	66.8	2	20443171 (1), 15645350 (1)
necrosis	61.8	101	1602741 (1), 8348981 (1), 8035808 (1), 7714166 (1) (see all 97)
vesicular stomatitis	59.1	8	8107259 (2), 15651759 (1), 17142768 (1), 11739693 (1) (see all 7)
hepatitis c chronic	55.8	32	12680611 (2), 19329508 (2), 9041468 (2), 9058311 (2) (see all 19)
disability	54.7	65	17694348 (4), 17439902 (3), 18562504 (3), 19847899 (3) (see all 38)
tumors	53.7	265	11592839 (3), 11498771 (3), 9826714 (3), 15891773 (3) (see all 99)
melanoma	51.6	126	1378904 (5), 1672507 (5), 17675472 (4), 7753561 (3) (see all 59)

Genetic Association Database (GAD): IFNB1
Human Genome Epidemiology (HuGE) Navigator: IFNB1 (21 documents)

Export disorders for IFNB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFNB1 gene, integrated from 9 sources (see all 1486):
(articles sorted by number of sources associating them with IFNB1)

Utopia: connect your pdf to the dynamic
world of online information

Association between IFNA genotype and the risk of sarcoidosis. (PubMed id 15004750)^{1, 4, 9} Akahoshi M....Shirakawa T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density. (PubMed id 14727154)^{1, 4} Mizuguchi T.... Yoshiura K. (2004)
Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. (PubMed id 12761564)^{1, 4} Aucan C....Hill A.V. (2003)
The crystal structure of human interferon beta at 2.2-A resolution. (PubMed id 9342320)^{1, 2} Karpusas M.... Goelz S. (1997)
On the relationship between human interferon alpha 1 and beta 1 genes. (PubMed id 2414376)^{1, 2} May L.T. and Sehgal P.B. (1985)
Assignment of the disulphide bonds of leukocyte interferon. (PubMed id 6162107)^{1, 2} Wetzel R. (1981)
Human fibroblast interferon gene lacks introns. (PubMed id 6164984)^{1, 2} Lawn R.M....Goeddel D.V. (1981)
Structure of a chromosomal gene for human interferon beta. (PubMed id 16593086)^{1, 2} Ohno S. and Taniguchi T. (1981)
A single amino acid change in IFN-beta1 abolishes its antiviral activity. (PubMed id 6171735)^{1, 2} Shepard H.M.... Goeddel D.V. (1981)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3456	HGNC: 5434	AceView: IFNB1	Ensembl:ENSG00000171855	euGenes: HUgn3456
ECgene: IFNB1	Kegg: 3456	H-InvDB: IFNB1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFNB1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IFNB1	Genetics and Cytogenetics in Oncology and Haematology
Avonex	http://www.avonex.com/index.xml
Betaseron	http://www.betaseron.com/home

Intellectual Property for IFNB1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IFNB1 gene:
Search GeneIP for patents involving IFNB1

GeneCards and IP:
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IFNB1 Gene

interferon, beta 1, fibroblast

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