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Aliases for IFNB1 Gene

Aliases for IFNB1 Gene

  • Interferon, Beta 1, Fibroblast 2 3
  • Fibroblast Interferon 3 4
  • IFN-Beta 3 4
  • IFNB 3 4
  • IFB 3 4
  • Interferon Beta 3
  • IFF 3

External Ids for IFNB1 Gene

Previous HGNC Symbols for IFNB1 Gene

  • IFNB

Previous GeneCards Identifiers for IFNB1 Gene

  • GC09M021404
  • GC09M021278
  • GC09M021067
  • GC09M021040

Summaries for IFNB1 Gene

GeneCards Summary for IFNB1 Gene

IFNB1 (Interferon, Beta 1, Fibroblast) is a Protein Coding gene. Diseases associated with IFNB1 include relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include transcription corepressor activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNB1 Gene

  • Has antiviral, antibacterial and anticancer activities

Gene Wiki entry for IFNB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNB1 Gene

Genomics for IFNB1 Gene

Regulatory Elements for IFNB1 Gene

Genomic Location for IFNB1 Gene

21,077,105 bp from pter
21,077,963 bp from pter
859 bases
Minus strand

Genomic View for IFNB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNB1 Gene

Proteins for IFNB1 Gene

  • Protein details for IFNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon beta
    Protein Accession:
    Secondary Accessions:
    • Q5VWC9

    Protein attributes for IFNB1 Gene

    187 amino acids
    Molecular mass:
    22294 Da
    Quaternary structure:
    • Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways

    Three dimensional structures from OCA and Proteopedia for IFNB1 Gene

neXtProt entry for IFNB1 Gene

Proteomics data for IFNB1 Gene at MOPED

Post-translational modifications for IFNB1 Gene

  • Glycosylation at Asn101
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for IFNB1 Gene

Domains for IFNB1 Gene

Gene Families for IFNB1 Gene

  • IFN :Interferons

Suggested Antigen Peptide Sequences for IFNB1 Gene

Graphical View of Domain Structure for InterPro Entry



  • P01574
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNB1: view

Function for IFNB1 Gene

Molecular function for IFNB1 Gene

GENATLAS Biochemistry:
interferon type I,beta 1,fibroblast,22.3kDa
UniProtKB/Swiss-Prot Function:
Has antiviral, antibacterial and anticancer activities

Gene Ontology (GO) - Molecular Function for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 19008854
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding NAS 2414376
genes like me logo Genes that share ontologies with IFNB1: view
genes like me logo Genes that share phenotypes with IFNB1: view

Animal Models for IFNB1 Gene

MGI Knock Outs for IFNB1:

Animal Model Products

miRNA for IFNB1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IFNB1 Gene

Localization for IFNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNB1 Gene


Subcellular locations from

Jensen Localization Image for IFNB1 Gene COMPARTMENTS Subcellular localization image for IFNB1 gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNB1: view

Pathways for IFNB1 Gene

genes like me logo Genes that share pathways with IFNB1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002312 B cell activation involved in immune response IMP 12932356
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
genes like me logo Genes that share ontologies with IFNB1: view

Compounds for IFNB1 Gene


Pharmaceutical: Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions

(2) Drugbank Compounds for IFNB1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3458-28-4 target
50-99-7 target

(133) Novoseek inferred chemical compound relationships for IFNB1 Gene

Compound -log(P) Hits PubMed IDs
betaseron 91.4 21
rebif 91 16
avonex 90.9 17
2,5-oligoadenylate 82 27
polyinosinic-polycytidylic acid 81.9 32
genes like me logo Genes that share compounds with IFNB1: view

Transcripts for IFNB1 Gene

mRNA/cDNA for IFNB1 Gene

(9) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNB1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNB1 Gene

No ASD Table

Relevant External Links for IFNB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNB1 Gene

mRNA expression in normal human tissues for IFNB1 Gene

SOURCE GeneReport for Unigene cluster for IFNB1 Gene Hs.93177

genes like me logo Genes that share expressions with IFNB1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for IFNB1 Gene

Orthologs for IFNB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia IFNB1 35
  • 75.27 (n)
  • 60.22 (a)
IFNB1 36
  • 56 (a)
(Mus musculus)
Mammalia Ifnb1 35
  • 67.4 (n)
  • 50.55 (a)
Ifnb1 16
Ifnb1 36
  • 51 (a)
(Pan troglodytes)
Mammalia IFNB1 35
  • 98.75 (n)
  • 97.33 (a)
IFNB1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Ifnb1 35
  • 67.75 (n)
  • 50 (a)
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
IFNB1 36
  • 56 (a)
IFNB2 36
  • 60 (a)
IFNB3 36
  • 56 (a)
IL6 36
  • 59 (a)
(Monodelphis domestica)
Mammalia IFN1 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia IFN5 36
  • 38 (a)
(Gallus gallus)
Aves -- 36
  • 27 (a)
-- 36
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
-- 36
  • 25 (a)
-- 36
  • 26 (a)
-- 36
  • 27 (a)
-- 36
  • 28 (a)
-- 36
  • 26 (a)
Species with no ortholog for IFNB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNB1 Gene

Gene Tree for IFNB1 (if available)
Gene Tree for IFNB1 (if available)

Paralogs for IFNB1 Gene

Selected SIMAP similar genes for IFNB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IFNB1: view

Variants for IFNB1 Gene

Sequence variations from dbSNP and Humsavar for IFNB1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1051922 -- 21,077,717(-) GAATA(C/T)TGCCT reference, synonymous-codon
rs1364612 -- 21,076,687(-) CTCCT(C/G)GAAAG downstream-variant-500B
rs1364613 -- 21,076,680(-) AAAGA(G/T)TTTTA downstream-variant-500B
rs1424855 -- 21,078,816(-) TGTCT(C/G)TGTTG upstream-variant-2KB
rs1424856 -- 21,078,741(-) CTGTG(A/G)CTGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNB1 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv466294 CNV Loss 19166990
nsv892732 CNV Loss 21882294

Relevant External Links for IFNB1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNB1 Gene

Disorders for IFNB1 Gene

(94) Novoseek inferred disease relationships for IFNB1 Gene

Disease -log(P) Hits PubMed IDs
multiple sclerosis relapsing-remitting 90.6 76
multiple sclerosis 88.5 139
virus infection 73.9 97
secondary progressive multiple sclerosis 66.8 2
necrosis 61.8 97

Relevant External Links for IFNB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IFNB1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for IFNB1 Gene

Publications for IFNB1 Gene

  1. Association between IFNA genotype and the risk of sarcoidosis. (PMID: 15004750) Akahoshi M. … Shirakawa T. (Hum. Genet. 2004) 3 23 48
  2. Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon beta. (PMID: 14519761) Tliba O. … Amrani Y. (J. Biol. Chem. 2003) 3 23
  3. Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes. (PMID: 15737993) Li K. … Lemon S.M. (J. Biol. Chem. 2005) 3 23
  4. Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon. (PMID: 10229237) Eto T. … Takahashi H. (Nat. Med. 1999) 3 23
  5. IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7. (PMID: 10918594) SancAcau J. … Wietzerbin J. (Oncogene 2000) 3 23

Products for IFNB1 Gene

  • Addgene plasmids for IFNB1

Sources for IFNB1 Gene

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