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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNB1 Gene

protein-coding   GIFtS: 65
GCID: GC09M021077

Interferon, Beta 1, Fibroblast


(Previous symbol: IFNB)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Beta 1, Fibroblast1 2     IFN-beta2 3
IFNB1 2 3     IFF2
Fibroblast Interferon2 3     Interferon Beta2
IFB2 3     

External Ids:    HGNC: 54341   Entrez Gene: 34562   Ensembl: ENSG000001718557   OMIM: 1476405   UniProtKB: P015743   

Export aliases for IFNB1 gene to outside databases

Previous GC identifers: GC09M021404 GC09M021278 GC09M021067 GC09M021040


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFNB1 Gene: 
IFNB1 (interferon, beta 1, fibroblast) is a protein-coding gene. Diseases associated with IFNB1 include oral erosive lichen, and cerebral primitive neuroectodermal tumor, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include interferon-alpha/beta receptor binding and transcription corepressor activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574
Function: Has antiviral, antibacterial and anticancer activities

Gene Wiki entry for IFNB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFNB1 gene promoter:
         STAT1   AP-1   ATF-2   Evi-1   POU2F1   POU2F1a   IRF-7A   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFNB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNB1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021077:  view genomic region     (about GC identifiers)

Start:
21,077,104 bp from pter      End:
21,077,943 bp from pter
Size:
840 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574 (See protein sequence)
Recommended Name: Interferon beta precursor  
Size: 187 amino acids; 22294 Da
Subunit: Monomer
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for IFNB1:
1AU1 (3D)    

Explore the universe of human proteins at neXtProt for IFNB1: NX_P01574

Explore proteomics data for IFNB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01574

  • IFNB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFNB1 Protein Expression
    REFSEQ proteins: NP_002167.1  
    ENSEMBL proteins: 
     ENSP00000369581  
    Reactome Protein details: P01574
    Human Recombinant Protein Products for IFNB1: 
    EMD Millipore Purified and/or Recombinant IFNB1 Protein
    R&D Systems Recombinant & Natural Proteins for IFNB1 (IFN-beta)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IFNB1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IFNB1
    GenScript Custom Purified and Recombinant Proteins Services for IFNB1
    Novus Biologicals IFNB1 Proteins
    Novus Biologicals IFNB1 Lysates
    Sino Biological Recombinant Protein for IFNB1
    Sino Biological Cell Lysate for IFNB1 
    ProSpec Recombinant Protein for IFNB1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    IFNB1 for ontologies           About GeneDecksing



    IFNB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IFNB1
    R&D Systems Antibodies for IFNB1 (IFN-beta)
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    OriGene Custom Antibody Services for IFNB1
    GenScript Custom Superior Antibodies Services for IFNB1
    Novus Biologicals IFNB1 Antibodies
    Abcam antibodies for IFNB1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for IFNB1
    LSBio Antibodies in human, mouse, rat for IFNB1 

    Assay Products for IFNB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IFNB1
    R&D Systems ELISAs for IFNB1 (IFN-beta)
    GenScript Custom Assay Services for IFNB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFN: Interferons

    4 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR000471 Interferon_alpha/beta/delta
     IPR009079 4_helix_cytokine-like_core
     IPR015588 Interferon_beta

    Graphical View of Domain Structure for InterPro Entry P01574

    ProtoNet protein and cluster: P01574

    1 Blocks protein domain: IPB000471 Interferon alpha

    UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574
    Similarity: Belongs to the alpha/beta interferon family


    IFNB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFNB_HUMAN, P01574
    Function: Has antiviral, antibacterial and anticancer activities

         Genatlas biochemistry entry for IFNB1:
    interferon type I,beta 1,fibroblast,22.3kDa

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IDA16873258
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding ----
    GO:0005132interferon-alpha/beta receptor binding NAS2414376
         
    IFNB1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ifnb1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     no phenotypic analysis  normal  skeleton  tumorigenesis 

    IFNB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ifnb1tm1Tl for IFNB1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNB1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFNB1:
    hsa-mir-145 (MIRT004616), hsa-let-7b (MIRT004614), hsa-mir-26a (MIRT004615), hsa-mir-34a (MIRT004617)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNB1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFNB1
    SwitchGear 3'UTR luciferase reporter plasmidIFNB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFNB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFNB1
    Sirion Biotech Customized adenovirus for overexpression of IFNB1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IFNB1 (see all 6)
    OriGene ORF clones in mouse, rat for IFNB1
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    GenScript: all cDNA clones in your preferred vector: IFNB1 (NM_002176)
    Sino Biological Human cDNA Clone for IFNB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNB1
    Sirion Biotech Customized lentivirus for stable overexpression of IFNB1 
                         Customized lentivirus expression plasmids for stable overexpression of IFNB1 

    Cell Line
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    Search LifeMap BioReagents cell lines for IFNB1
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFNB1 About   (see all 30)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    2Immune response IFN alpha/beta signaling pathway
    Immune response IFN alpha/beta signaling pathway0.71
    Interferon alpha/beta signaling0.45
    Regulation of IFNA signaling0.71
    3Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    4Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    5RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    RIG-I-like receptor signaling pathway0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for IFNB1
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response IFN alpha/beta signaling pathway
    Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

    2 R&D Systems Pathways for IFNB1
        NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNB1
        Cytokine Network
    Interferon Pathway
    JAK-STAT Pathway
    all-trans-Retinoic Acid Mediated Apoptosis

    3 GeneGo (Thomson Reuters) Pathways for IFNB1
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR signaling pathways
    Immune response IFN alpha/beta signaling pathway

    5/7 BioSystems Pathways for IFNB1 (see all 7)
        EBV LMP1 signaling
    Cytokines and Inflammatory Response
    Senescence and Autophagy
    Type II interferon signaling (IFNG)
    Toll-like receptor signaling pathway


    5/11        Reactome Pathways for IFNB1 (see all 11)
        Hemostasis
    Regulation of IFNA signaling
    Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways


    5/15         Kegg Pathways  (Kegg details for IFNB1) (see all 15):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway


    IFNB1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for IFNB1 (P015743 ENSP000003695814) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFNAR2P485513, ENSP000003439574I2D: score=1 STRING: ENSP00000343957
    IFNAR1P171813, ENSP000002701394I2D: score=1 STRING: ENSP00000270139
    CREBBPENSP000002623674STRING: ENSP00000262367
    EP300ENSP000002632534STRING: ENSP00000263253
    IFNA14ENSP000003695714STRING: ENSP00000369571
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002250adaptive immune response IEA--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process NAS10918594
    GO:0006952defense response ----
    GO:0006959humoral immune response IEA--
    GO:0007166cell surface receptor signaling pathway TAS10640778

    IFNB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IFNB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFNB1 (IFNB)

    UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574
    Pharmaceutical: Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the
    treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue
    substitutions

    2 DrugBank Compounds for IFNB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423
    Beta-D-Glucose-- 50-99-7target--17139284 17016423

    10/133 Novoseek inferred chemical compound relationships for IFNB1 gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    betaseron 91.4 36 12581490 (2), 10485260 (2), 16042224 (1), 17273808 (1) (see all 19)
    rebif 91 20 12581490 (2), 16042224 (1), 17273808 (1), 10378715 (1) (see all 15)
    avonex 90.9 21 10485260 (2), 16042224 (1), 16170498 (1), 17273808 (1) (see all 16)
    2',5'-oligoadenylate 82 32 2121851 (3), 2395002 (2), 8103050 (1), 2086672 (1) (see all 24)
    polyinosinic-polycytidylic acid 81.9 39 2177082 (4), 19452017 (3), 1666117 (3), 1602741 (2) (see all 23)
    glatiramer acetate 81.2 114 14760948 (6), 11730946 (5), 17661794 (4), 19609087 (3) (see all 36)
    ifn-alpha 80.1 44 20299237 (4), 14719113 (2), 12725866 (1), 16736505 (1) (see all 39)
    poly(i-c) 79.8 40 19669308 (3), 19728309 (3), 17142768 (2), 14596815 (2) (see all 27)
    edss 76.8 17 12446026 (1), 18353125 (1), 14669137 (1), 17439902 (1) (see all 15)
    mezerein 76.2 77 8545104 (4), 7753561 (3), 1357650 (3), 7566979 (2) (see all 19)

    Search CenterWatch for drugs/clinical trials and news about IFNB1 / IFNB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFNB1 gene: 
    NM_002176.2  

    Unigene Cluster for IFNB1:

    Interferon, beta 1, fibroblast
    Hs.93177
    Unigene Representative Sequence: M28622
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380232(uc003zok.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    GenScript: all cDNA clones in your preferred vector: IFNB1 (NM_002176)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNB1
    Sirion Biotech Customized lentivirus for stable overexpression of IFNB1 
                         Customized lentivirus expression plasmids for stable overexpression of IFNB1 
    Primer
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    OriGene qPCR primer pairs and template standards for IFNB1
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNB1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNB1

    Additional mRNA sequence: 

    AB451323.1 AB451452.1 AB451491.1 BC069314.1 BC096150.3 BC096151.2 BC096152.2 BC096153.2 
    M17373.2 M25460.1 M28622.1 V00546.1 V00547.1 

    1 DOTS entry:

    DT.455910 

    9 AceView cDNA sequences:

    V00546 NM_002176 BC069314 M28622 R63093 V00547 M25460 M17373 
    R63139 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFNB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGTCTGC
    IFNB1 Expression
    About this image


    See IFNB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFNB1

    SOURCE GeneReport for Unigene cluster: Hs.93177
        SABiosciences Expression via Pathway-Focused PCR Arrays including IFNB1 (see all 14): 
              HIV Host Response in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Interferons & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFNB1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifnb11 , 5 interferon beta 1, fibroblast1, 5 67.03(n)1
    50(a)1
      4 (41.91 cM)5
    159771  NM_010510.11  NP_034640.11 
     885220255 
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 14)
    --
    29(a)
    27(a)
    (see all 14)
    many ↔ many
    many ↔ many
    (see all 14)
    Z(34143597-34144148)
    AADN03019112.1(8049-9473)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    29(a)
    28(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    2(61647787-61648344)
    2(61644933-61645472)
    zebrafish
    (Danio rerio)
    Actinopterygii ifnphi36
    ifnphi26
    interferon phi 2
    27(a)
    23(a)
    many ↔ many
    many ↔ many
    3(22558521-22560658)
    3(22565711-22572180)


    ENSEMBL Gene Tree for IFNB1 (if available)
    TreeFam Gene Tree for IFNB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFNB1 gene
    IFNA72  IFNA22  IFNA42  IFNE2  IFNA142  IFNA52  IFNK2  IFNA12  
    IFNA212  IFNA172  IFNA62  IFNA132  IFNW12  IFNA162  IFNA102  IFNA82  
    18 SIMAP similar genes for IFNB1 using alignment to 3 protein entries:     IFNB_HUMAN (see all proteins):
    IFNW1    IFNA16    IFNA10    IFNA17    IFNA21    IFNA4
    IFNA    IFNE    IFNA8    IFNA14    IFNA1    IFNA13
    IFNA5    IFNA7    IFNA2    IFNA6    IFNA2B    IFNK

    IFNB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/95 SNPs in IFNB1 are shown (see all 95)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363304
    A breast cancer sample4--see VAR_0363302 W C mis40--------
    VAR_0040164
    ----see VAR_0040162 C Y mis40--------
    rs13646131,2
    C,F,A--21076679(-) AAAGAT/GTTTTA 1 -- ds50015Minor allele frequency- G:0.18WA NA EA 362
    rs13646121,2
    C,F,A,H--21076686(-) CTCCTC/GGAAAG 1 -- ds500112Minor allele frequency- G:0.08NA NS EA WA 894
    rs283681261,2
    C--21076693(-) ATACT-/TTGCTC 1 -- ds50010--------
    rs1448992441,2
    --21076701(+) GTATCC/GCCCAA 1 -- ds50010--------
    rs1180916851,2
    C,F--21076711(+) AATAAC/AGTGGG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs283681251,2
    C--21076738(-) GTCAG-/CTTTTG 1 -- ds50010--------
    rs1854484111,2
    --21076750(+) TATTCC/GTCTGG 1 -- ds50010--------
    rs1895282671,2
    --21076758(+) TGGCTA/CTTCCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for IFNB1 (21077104 - 21077943 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IFNB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv466294CNV Loss19166990
    nsv892732CNV Loss21882294
    nsv892724CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNB1
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147640    OMIM disorders: --

    20/159 diseases for IFNB1 (see all 159):    About MalaCards
    oral erosive lichen    cerebral primitive neuroectodermal tumor    newcastle disease    bursitis
    common wart    retinal vasculitis    chronic inflammatory demyelinating polyradiculoneuropathy    relapsing-remitting multiple sclerosis
    parainfluenza virus type 3    polyradiculoneuropathy    measles    primitive neuroectodermal tumor
    cytomegalovirus retinitis    venezuelan equine encephalitis    diffuse astrocytoma    panniculitis
    myelitis    influenza    multiple sclerosis    avian influenza

    9 diseases from the University of Copenhagen DISEASES database for IFNB1:
    Multiple sclerosis     Optic neuritis     Chronic inflammatory demyelinating polyradiculoneuropathy     Progressive multifocal leukoencephalopathy
    Hepatitis C     Melanoma     Neuromyelitis optica     Hepatitis
    Malignant glioma

    IFNB1 for disorders           About GeneDecksing

    10/94 Novoseek inferred disease relationships for IFNB1 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple sclerosis relapsing-remitting 90.6 89 18562504 (2), 19932513 (2), 19506220 (2), 11911803 (2) (see all 70)
    multiple sclerosis 88.5 343 14607790 (7), 19604093 (3), 9686625 (3), 10570511 (3) (see all 99)
    virus infection 73.9 114 12654014 (4), 15210742 (3), 10074115 (3), 10024886 (3) (see all 83)
    secondary progressive multiple sclerosis 66.8 2 20443171 (1), 15645350 (1)
    necrosis 61.8 101 1602741 (1), 8348981 (1), 8035808 (1), 7714166 (1) (see all 97)
    vesicular stomatitis 59.1 8 8107259 (2), 15651759 (1), 17142768 (1), 11739693 (1) (see all 7)
    hepatitis c chronic 55.8 32 12680611 (2), 19329508 (2), 9041468 (2), 9058311 (2) (see all 19)
    disability 54.7 65 17694348 (4), 17439902 (3), 18562504 (3), 19847899 (3) (see all 38)
    tumors 53.7 265 11592839 (3), 11498771 (3), 9826714 (3), 15891773 (3) (see all 99)
    melanoma 51.6 126 1378904 (5), 1672507 (5), 17675472 (4), 7753561 (3) (see all 59)

    Genetic Association Database (GAD): IFNB1
    Human Genome Epidemiology (HuGE) Navigator: IFNB1 (21 documents)

    Export disorders for IFNB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFNB1 gene, integrated from 9 sources (see all 1504):
    (articles sorted by number of sources associating them with IFNB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between IFNA genotype and the risk of sarcoidosis. (PubMed id 15004750)1, 4, 9 Akahoshi M....Shirakawa T. (2004)
    2. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    3. Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    7. Genetic variants at CD28, PRDM1 and CD2/CD58 are asso ciated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (2009)
    8. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    9. Role of polymorphisms of the inflammatory response ge nes and DC-SIGNR in genetic susceptibility to SARS and other infections. (PubMed id 18708672)1, 4 Khoo U.S....Peiris J.S. (2008)
    10. Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. (PubMed id 18715339)1, 4 Dhiman N....Poland G.A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3456 HGNC: 5434 AceView: IFNB1 Ensembl:ENSG00000171855 euGenes: HUgn3456
    ECgene: IFNB1 Kegg: 3456 H-InvDB: IFNB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFNB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IFNB1 Genetics and Cytogenetics in Oncology and Haematology
    Avonexhttp://www.avonex.com/index.xml
    Betaseronhttp://www.betaseron.com/home

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFNB1 gene:
    Search GeneIP for patents involving IFNB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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