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IFNB1 Gene

protein-coding   GIFtS: 66
GCID: GC09M021077

Interferon, Beta 1, Fibroblast


(Previous symbol: IFNB)
  See IFNB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Beta 1, Fibroblast1 2     IFN-beta2 3
IFNB1 2 3     IFF2
Fibroblast Interferon2 3     Interferon Beta2
IFB2 3     

External Ids:    HGNC: 54341   Entrez Gene: 34562   Ensembl: ENSG000001718557   OMIM: 1476405   UniProtKB: P015743   

Export aliases for IFNB1 gene to outside databases

Previous GC identifers: GC09M021404 GC09M021278 GC09M021067 GC09M021040


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFNB1 Gene:
IFNB1 (interferon, beta 1, fibroblast) is a protein-coding gene. Diseases associated with IFNB1 include relapsing-remitting multiple sclerosis, and secondary progressive multiple sclerosis. GO annotations related to this gene include type I interferon receptor binding and transcription corepressor activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574
Function: Has antiviral, antibacterial and anticancer activities

Gene Wiki entry for IFNB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFNB1 gene promoter:
         STAT1   AP-1   ATF-2   Evi-1   POU2F1   POU2F1a   IRF-7A   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNB1 promoter sequence
   Search Chromatin IP Primers for IFNB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNB1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021077:  view genomic region     (about GC identifiers)

Start:
21,077,104 bp from pter      End:
21,077,943 bp from pter
Size:
840 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574 (See protein sequence)
Recommended Name: Interferon beta precursor  
Size: 187 amino acids; 22294 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for IFNB1:
1AU1 (3D)    

Explore the universe of human proteins at neXtProt for IFNB1: NX_P01574

Explore proteomics data for IFNB1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn101
  • Modification sites at PhosphoSitePlus

  • See IFNB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002167.1  
    ENSEMBL proteins: 
     ENSP00000369581  
    Reactome Protein details: P01574

    IFNB1 Human Recombinant Protein Products:

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    Novus Biologicals IFNB1 Proteins
    Novus Biologicals IFNB1 Lysates
    Sino Biological Recombinant Protein for IFNB1
    Sino Biological Cell Lysate for IFNB1
    ProSpec Recombinant Protein for IFNB1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IFNB1 

     
    antibodies-online proteins for IFNB1 (48 products) 

     
    antibodies-online peptides for IFNB1

    IFNB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IFNB1
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    antibodies-online antibodies for IFNB1 (190 products) 

    IFNB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IFNB1 
    antibodies-online kits for IFNB1 (53 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFN: Interferons

    4 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR000471 Interferon_alpha/beta/delta
     IPR009079 4_helix_cytokine-like_core
     IPR015588 Interferon_beta

    Graphical View of Domain Structure for InterPro Entry P01574

    ProtoNet protein and cluster: P01574

    1 Blocks protein domain: IPB000471 Interferon alpha

    UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574
    Similarity: Belongs to the alpha/beta interferon family


    Find genes that share domains with IFNB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFNB_HUMAN, P01574
    Function: Has antiviral, antibacterial and anticancer activities

         Genatlas biochemistry entry for IFNB1:
    interferon type I,beta 1,fibroblast,22.3kDa

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ----
    GO:0005125cytokine activity IDA19008854
    GO:0005126cytokine receptor binding ----
    GO:0005132type I interferon receptor binding NAS2414376
         
    Find genes that share ontologies with IFNB1           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ifnb1):
     hematopoietic system  homeostasis/metabolism  immune system  nervous system  no phenotypic analysis 
     normal  skeleton  tumorigenesis 

    Find genes that share phenotypes with IFNB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ifnb1tm1Tl for IFNB1

       genOway: Develop your customized and physiologically relevant rodent model for IFNB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFNB1:
    hsa-mir-145-5p (MIRT004616), hsa-let-7b-5p (MIRT004614), hsa-mir-26a-5p (MIRT004615), hsa-mir-34a-5p (MIRT004617)

    Block miRNA regulation of human, mouse, rat IFNB1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IFNB1
    SwitchGear 3'UTR luciferase reporter plasmidIFNB1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IFNB1
    Predesigned siRNA for gene silencing in human, mouse, rat IFNB1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IFNB1

    Clone
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    OriGene clones in human, mouse for IFNB1 (see all 5)
    OriGene ORF clones in mouse, rat for IFNB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNB1 (NM_002176)
    Sino Biological Human cDNA Clone for IFNB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNB1
    Addgene plasmids for IFNB1 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IFNB1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNB1

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11281) for IFNB1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFNB_HUMAN, P01574: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1
    cytosol1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IBA--

    Find genes that share ontologies with IFNB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFNB1 About   (see all 28)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    Regulation of toll-like receptor signaling pathway0.93
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    TRAF3-dependent IRF activation pathway0.00
    3Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    Regulation of IFNA signaling0.69
    4NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    NOD-like Receptor Signaling Pathways0.58
    5Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81


    Find genes that share SuperPaths with IFNB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IFNB1
        NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IFNB1
        Cytokine Network
    Interferon Pathway
    JAK-STAT Pathway
    all-trans-Retinoic Acid Mediated Apoptosis

    3 GeneGo (Thomson Reuters) Pathways for IFNB1
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR signaling pathways
    Immune response IFN alpha/beta signaling pathway

    Selected BioSystems Pathways for IFNB1 (see all 8)
        Cytokines and Inflammatory Response
    EBV LMP1 signaling
    Senescence and Autophagy
    Type II interferon signaling (IFNG)
    Toll-like receptor signaling pathway


    Selected Reactome Pathways for IFNB1 (see all 6)
        Regulation of IFNA signaling
    Oxidative Stress Induced Senescence
    Interferon alpha/beta signaling
    TRAF3-dependent IRF activation pathway
    Factors involved in megakaryocyte development and platelet production


    Selected Kegg Pathways  (Kegg details for IFNB1) (see all 15):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNB1 (see all 14): 
              HIV Host Response in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Interferons & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IFNB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFNB1 (P015743 ENSP000003695814) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFNAR2P485513, ENSP000003439574I2D: score=1 STRING: ENSP00000343957
    IFNAR1P171813, ENSP000002701394I2D: score=1 STRING: ENSP00000270139
    CREBBPENSP000002623674STRING: ENSP00000262367
    EP300ENSP000002632534STRING: ENSP00000263253
    IFNA14ENSP000003695714STRING: ENSP00000369571
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002250adaptive immune response IEA--
    GO:0002286T cell activation involved in immune response IBA--
    GO:0002312B cell activation involved in immune response IMP12932356
    GO:0002323natural killer cell activation involved in immune response IBA--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process ----

    Find genes that share ontologies with IFNB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFNB1 (IFNB)

    UniProtKB/Swiss-Prot: IFNB_HUMAN, P01574
    Pharmaceutical: Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the
    treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue
    substitutions

    2 DrugBank Compounds for IFNB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423
    Beta-D-Glucose-- 50-99-7target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for IFNB1 gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    betaseron 91.4 36 12581490 (2), 10485260 (2), 16042224 (1), 17273808 (1) (see all 19)
    rebif 91 20 12581490 (2), 16042224 (1), 17273808 (1), 10378715 (1) (see all 15)
    avonex 90.9 21 10485260 (2), 16042224 (1), 16170498 (1), 17273808 (1) (see all 16)
    2',5'-oligoadenylate 82 32 2121851 (3), 2395002 (2), 8103050 (1), 2086672 (1) (see all 24)
    polyinosinic-polycytidylic acid 81.9 39 2177082 (4), 19452017 (3), 1666117 (3), 1602741 (2) (see all 23)
    glatiramer acetate 81.2 114 14760948 (6), 11730946 (5), 17661794 (4), 19609087 (3) (see all 36)
    ifn-alpha 80.1 44 20299237 (4), 14719113 (2), 12725866 (1), 16736505 (1) (see all 39)
    poly(i-c) 79.8 40 19669308 (3), 19728309 (3), 17142768 (2), 14596815 (2) (see all 27)
    edss 76.8 17 12446026 (1), 18353125 (1), 14669137 (1), 17439902 (1) (see all 15)
    mezerein 76.2 77 8545104 (4), 7753561 (3), 1357650 (3), 7566979 (2) (see all 19)



    Find genes that share compounds with IFNB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFNB1 gene: 
    NM_002176.2  

    Unigene Cluster for IFNB1:

    Interferon, beta 1, fibroblast
    Hs.93177
    Unigene Representative Sequence: M28622
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380232(uc003zok.3)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: IFNB1 (NM_002176)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNB1
    Addgene plasmids for IFNB1 
    Primer
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    OriGene qPCR primer pairs and template standards for IFNB1
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFNB1
      QuantiTect SYBR Green Assays in human, mouse, rat IFNB1
      QuantiFast Probe-based Assays in human, mouse, rat IFNB1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11281) for IFNB1 

    Additional mRNA sequence: 

    AB451323.1 AB451452.1 AB451491.1 BC069314.1 BC096150.3 BC096151.2 BC096152.2 BC096153.2 
    M17373.2 M25460.1 M28622.1 V00546.1 V00547.1 

    1 DOTS entry:

    DT.455910 

    9 AceView cDNA sequences:

    V00546 NM_002176 BC069314 M28622 V00547 R63093 M25460 M17373 
    R63139 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFNB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGTCTGC
    IFNB1 Expression
    About this image

    IFNB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFNB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.93177
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNB1 (see all 14): 
              HIV Host Response in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Interferons & Receptors in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IFNB1
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    QuantiFast Probe-based Assays in human, mouse, rat IFNB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFNB1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifnb11 , 5 interferon beta 1, fibroblast1, 5 67.4(n)1
    50.55(a)1
      4 (41.91 cM)5
    159771  NM_010510.11  NP_034640.11 
     885220255 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    29(a)
    27(a)
    many ↔ many
    many ↔ many
    Z(34143597-34144148)
    AADN03019112.1(8049-9473)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    28(a)
    27(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    2(61647787-61648344)
    2(61644933-61645472)


    ENSEMBL Gene Tree for IFNB1 (if available)
    TreeFam Gene Tree for IFNB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for IFNB1 gene
    IFNA72  IFNA22  IFNA42  IFNE2  IFNA142  IFNA52  IFNK2  IFNA12  
    IFNA212  IFNA172  IFNA62  IFNA132  IFNW12  IFNA162  IFNA102  IFNA82  
    18 SIMAP similar genes for IFNB1 using alignment to 3 protein entries:     IFNB_HUMAN (see all proteins):
    IFNW1    IFNA16    IFNA10    IFNA17    IFNA21    IFNA4
    IFNA    IFNE    IFNA8    IFNA14    IFNA1    IFNA13
    IFNA5    IFNA7    IFNA2    IFNA6    IFNA2B    IFNK

    Find genes that share paralogs with IFNB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFNB1 (see all 95)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363304
    A breast cancer sample4--see VAR_0363302 W C mis40--------
    rs13646131,2
    C,F,A--21076679(-) AAAGAT/GTTTTA 1 -- ds50015Minor allele frequency- G:0.18WA NA EA 362
    rs13646121,2
    C,F,A,H--21076686(-) CTCCTC/GGAAAG 1 -- ds500112Minor allele frequency- G:0.08NA NS EA WA 894
    rs283681261,2
    C--21076693(-) ATACT-/TTGCTC 1 -- ds50010--------
    rs1448992441,2
    --21076701(+) GTATCC/GCCCAA 1 -- ds50010--------
    rs1180916851,2
    C,F--21076711(+) AATAAC/AGTGGG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs283681251,2
    C--21076738(-) GTCAG-/CTTTTG 1 -- ds50010--------
    rs1854484111,2
    --21076750(+) TATTCC/GTCTGG 1 -- ds50010--------
    rs1895282671,2
    --21076758(+) TGGCTA/CTTCCT 1 -- ds50010--------
    rs285399881,2
    C,F,H--21076883(+) CACAGC/AAGTTC 1 -- ds50014Minor allele frequency- A:0.02NS NA 516

    HapMap Linkage Disequilibrium report for IFNB1 (21077104 - 21077943 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IFNB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv466294CNV Loss19166990
    nsv892732CNV Loss21882294
    nsv892724CNV Gain21882294

    Human Gene Mutation Database (HGMD): IFNB1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNB1
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147640    OMIM disorders: --

    20 diseases for IFNB1:    
    About MalaCards
    relapsing-remitting multiple sclerosis    secondary progressive multiple sclerosis    oral erosive lichen    newcastle disease
    bursitis    primary progressive multiple sclerosis    common wart    polyradiculoneuropathy
    parainfluenza virus type 3    measles    retinal vasculitis    chronic inflammatory demyelinating polyradiculoneuropathy
    cerebral primitive neuroectodermal tumor    venezuelan equine encephalitis    influenza    primitive neuroectodermal tumor
    multiple sclerosis    herpes simplex    hepatitis c    malaria

    9 diseases from the University of Copenhagen DISEASES database for IFNB1:
    Multiple sclerosis     Optic neuritis     Chronic inflammatory demyelinating polyradiculoneuropathy     Progressive multifocal leukoencephalopathy
    Hepatitis C     Melanoma     Neuromyelitis optica     Hepatitis
    Malignant glioma

    Find genes that share disorders with IFNB1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IFNB1 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple sclerosis relapsing-remitting 90.6 89 18562504 (2), 19932513 (2), 19506220 (2), 11911803 (2) (see all 70)
    multiple sclerosis 88.5 343 14607790 (7), 19604093 (3), 9686625 (3), 10570511 (3) (see all 99)
    virus infection 73.9 114 12654014 (4), 15210742 (3), 10074115 (3), 10024886 (3) (see all 83)
    secondary progressive multiple sclerosis 66.8 2 20443171 (1), 15645350 (1)
    necrosis 61.8 101 1602741 (1), 8348981 (1), 8035808 (1), 7714166 (1) (see all 97)
    vesicular stomatitis 59.1 8 8107259 (2), 15651759 (1), 17142768 (1), 11739693 (1) (see all 7)
    hepatitis c chronic 55.8 32 12680611 (2), 19329508 (2), 9041468 (2), 9058311 (2) (see all 19)
    disability 54.7 65 17694348 (4), 17439902 (3), 18562504 (3), 19847899 (3) (see all 38)
    tumors 53.7 265 11592839 (3), 11498771 (3), 9826714 (3), 15891773 (3) (see all 99)
    melanoma 51.6 126 1378904 (5), 1672507 (5), 17675472 (4), 7753561 (3) (see all 59)

    Genetic Association Database (GAD): IFNB1
    Human Genome Epidemiology (HuGE) Navigator: IFNB1 (21 documents)

    Export disorders for IFNB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFNB1 gene, integrated from 10 sources (see all 1519):
    (articles sorted by number of sources associating them with IFNB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between IFNA genotype and the risk of sarcoidosis. (PubMed id 15004750)1, 4, 9 Akahoshi M....Shirakawa T. (Hum. Genet. 2004)
    2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    3. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (Fam. Cancer 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)
    8. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    9. Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections. (PubMed id 18708672)1, 4 Khoo U.S....Peiris J.S. (Hong Kong Med J 2008)
    10. Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. (PubMed id 18715339)1, 4 Dhiman N....Poland G.A. (Tissue Antigens 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3456 HGNC: 5434 AceView: IFNB1 Ensembl:ENSG00000171855 euGenes: HUgn3456
    ECgene: IFNB1 Kegg: 3456 H-InvDB: IFNB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFNB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IFNB1 Genetics and Cytogenetics in Oncology and Haematology
    Avonexhttp://www.avonex.com/index.xml
    Betaseronhttp://www.betaseron.com/home

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFNB1 gene:
    Search GeneIP for patents involving IFNB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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