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Aliases for IFNAR2 Gene

Aliases for IFNAR2 Gene

  • Interferon Alpha And Beta Receptor Subunit 2 2 3
  • Interferon (Alpha, Beta And Omega) Receptor 2 2 3 5
  • Interferon Alpha Binding Protein 3 4
  • Type I Interferon Receptor 2 3 4
  • IFN-Alpha/Beta Receptor 2 3 4
  • IFN-R-2 3 4
  • IFNABR 3 4
  • IFNARB 3 4
  • Interferon-Alpha/Beta Receptor Beta Chain 3
  • Human Interferon Alpha/Beta Receptor 3
  • IFN-Alpha Binding Protein 4
  • IFN-Alpha-REC 3
  • IFN-R 3
  • IMD45 3

External Ids for IFNAR2 Gene

Previous HGNC Symbols for IFNAR2 Gene

  • IFNABR

Previous GeneCards Identifiers for IFNAR2 Gene

  • GC21P031179
  • GC21P033522
  • GC21P033524
  • GC21P034602
  • GC21P020067

Summaries for IFNAR2 Gene

Entrez Gene Summary for IFNAR2 Gene

  • The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNAR2 Gene

IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2) is a Protein Coding gene. Diseases associated with IFNAR2 include hepatitis c and measles. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include protein kinase binding and type I interferon binding.

UniProtKB/Swiss-Prot for IFNAR2 Gene

  • Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).

Gene Wiki entry for IFNAR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNAR2 Gene

Genomics for IFNAR2 Gene

Regulatory Elements for IFNAR2 Gene

Promoters for IFNAR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IFNAR2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IFNAR2 gene promoter:

Genomic Location for IFNAR2 Gene

Chromosome:
21
Start:
33,229,895 bp from pter
End:
33,265,675 bp from pter
Size:
35,781 bases
Orientation:
Plus strand

Genomic View for IFNAR2 Gene

Genes around IFNAR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNAR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNAR2 Gene

Proteins for IFNAR2 Gene

  • Protein details for IFNAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48551-INAR2_HUMAN
    Recommended name:
    Interferon alpha/beta receptor 2
    Protein Accession:
    P48551
    Secondary Accessions:
    • A8KAJ4
    • D3DSE8
    • D3DSE9
    • Q15467
    • Q6FHD7

    Protein attributes for IFNAR2 Gene

    Size:
    515 amino acids
    Molecular mass:
    57759 Da
    Quaternary structure:
    • Heterodimer with IFNAR1 (PubMed:8181059, PubMed:7665574, PubMed:10049744, PubMed:24075985, PubMed:21854986). Isoform 1 interacts with the transcriptional factors STAT1 and STAT2 (PubMed:9121453). Interacts with JAK1 (PubMed:8181059, PubMed:7759950).

    Three dimensional structures from OCA and Proteopedia for IFNAR2 Gene

    Alternative splice isoforms for IFNAR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFNAR2 Gene

Proteomics data for IFNAR2 Gene at MOPED

Post-translational modifications for IFNAR2 Gene

  • Glycosylated.
  • Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
  • Glycosylation at Asn 58, Asn 87, Asn 116, Asn 188, and Asn 192
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for IFNAR2 (IFN-alpha/beta R2)

No data available for DME Specific Peptides for IFNAR2 Gene

Domains & Families for IFNAR2 Gene

Gene Families for IFNAR2 Gene

Protein Domains for IFNAR2 Gene

Suggested Antigen Peptide Sequences for IFNAR2 Gene

Graphical View of Domain Structure for InterPro Entry

P48551

UniProtKB/Swiss-Prot:

INAR2_HUMAN :
  • Belongs to the type II cytokine receptor family.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IFNAR2: view

Function for IFNAR2 Gene

Molecular function for IFNAR2 Gene

GENATLAS Biochemistry:
interferon alpha/beta (type I) receptor,beta subunit,identified by monoclonal antibody IFNAR beta 1,cytokin receptor family II,member
UniProtKB/Swiss-Prot Function:
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).

Gene Ontology (GO) - Molecular Function for IFNAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 7665574
GO:0019901 protein kinase binding IPI 7759950
genes like me logo Genes that share ontologies with IFNAR2: view
genes like me logo Genes that share phenotypes with IFNAR2: view

Animal Models for IFNAR2 Gene

MGI Knock Outs for IFNAR2:

Animal Model Products

miRNA for IFNAR2 Gene

miRTarBase miRNAs that target IFNAR2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNAR2 Gene

Localization for IFNAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNAR2 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNAR2 Gene COMPARTMENTS Subcellular localization image for IFNAR2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IFNAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 7588638
GO:0005887 integral component of plasma membrane IDA 7759950
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFNAR2: view

Pathways & Interactions for IFNAR2 Gene

genes like me logo Genes that share pathways with IFNAR2: view

SIGNOR curated interactions for IFNAR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IFNAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0009615 response to virus TAS 7588638
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0060338 regulation of type I interferon-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IFNAR2: view

Drugs & Compounds for IFNAR2 Gene

(14) Drugs for IFNAR2 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Interferon Alfa-2a, Recombinant Approved Pharma binder, Target 0
Interferon Alfa-2b, Recombinant Approved Pharma binder, Target 0
Interferon alfacon-1 Approved Pharma binder, Target 13
Interferon alfa-n1 Approved Pharma binder, Target, agonist 0
Interferon alfa-n3 Approved, Investigational Pharma binder, Target, agonist 0

(6) Additional Compounds for IFNAR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNAR2: view

Transcripts for IFNAR2 Gene

Unigene Clusters for IFNAR2 Gene

Interferon (alpha, beta and omega) receptor 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: -
SP7: -
SP8: -
SP9: - -

Relevant External Links for IFNAR2 Gene

GeneLoc Exon Structure for
IFNAR2
ECgene alternative splicing isoforms for
IFNAR2

Expression for IFNAR2 Gene

mRNA expression in normal human tissues for IFNAR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFNAR2 Gene

This gene is overexpressed in Whole Blood (x6.5).

Protein differential expression in normal tissues from HIPED for IFNAR2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFNAR2 Gene



SOURCE GeneReport for Unigene cluster for IFNAR2 Gene Hs.708195

mRNA Expression by UniProt/SwissProt for IFNAR2 Gene

P48551-INAR2_HUMAN
Tissue specificity: Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
genes like me logo Genes that share expression patterns with IFNAR2: view

Protein tissue co-expression partners for IFNAR2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for IFNAR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNAR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFNAR2 35
  • 73.29 (n)
  • 59.25 (a)
IFNAR2 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFNAR2 35
  • 73.59 (n)
  • 59.61 (a)
-- 36
  • 58 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifnar2 35
  • 64.91 (n)
  • 49.59 (a)
Ifnar2 16
Ifnar2 36
  • 47 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IFNAR2 35
  • 98.58 (n)
  • 97.86 (a)
IFNAR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifnar2 35
  • 66.67 (n)
  • 50.92 (a)
oppossum
(Monodelphis domestica)
Mammalia IFNAR2 36
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFNAR2 36
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves IFNAR2 35
  • 44.8 (n)
  • 29.51 (a)
IFNAR2 36
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFNAR2 36
  • 22 (a)
OneToOne
Species with no ortholog for IFNAR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNAR2 Gene

ENSEMBL:
Gene Tree for IFNAR2 (if available)
TreeFam:
Gene Tree for IFNAR2 (if available)

Paralogs for IFNAR2 Gene

No data available for Paralogs for IFNAR2 Gene

Variants for IFNAR2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNAR2 Gene

P48551-INAR2_HUMAN
Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].

Sequence variations from dbSNP and Humsavar for IFNAR2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2229207 - 33,241,945(+) TGCCT(C/T)CATCT reference, missense
rs1051393 - 33,241,950(+) TCATC(A/G/T)TCAGA reference, missense
rs17860223 - 33,252,707(+) CCTAT(A/G)TCATT reference, missense
rs1187 -- 33,238,588(-) GTCAT(A/C)ATCAG intron-variant
rs3153 -- 33,237,200(-) TGTGG(C/T)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFNAR2 Gene

Variant ID Type Subtype PubMed ID
dgv4734n71 CNV Loss 21882294
dgv4735n71 CNV Loss 21882294
nsv913705 CNV Loss 21882294
nsv913706 CNV Loss 21882294
esv2723349 CNV Deletion 23290073
esv990908 CNV Deletion 20482838
esv2723351 CNV Deletion 23290073
dgv4736n71 CNV Loss 21882294
nsv913709 CNV Loss 21882294
dgv4737n71 CNV Loss 21882294
nsv913714 CNV Gain 21882294

Variation tolerance for IFNAR2 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNAR2 Gene

HapMap Linkage Disequilibrium report
IFNAR2
Human Gene Mutation Database (HGMD)
IFNAR2

Disorders for IFNAR2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for IFNAR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis c
  • chronic hepatitis c
measles
  • morbilli
coronary aneurysm
  • aneurysm of coronary vessels
heart aneurysm
  • cardiac aneurysm
hepatitis
  • hepatitis a
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IFNAR2

Genetic Association Database (GAD)
IFNAR2
Human Genome Epidemiology (HuGE) Navigator
IFNAR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNAR2
genes like me logo Genes that share disorders with IFNAR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNAR2 Gene

Publications for IFNAR2 Gene

  1. The human interferon alpha/beta receptor: characterization and molecular cloning. (PMID: 8181059) Novick D. … Rubinstein M. (Cell 1994) 2 3 4 23 67
  2. Interferon alpha receptor 2 expression by peripheral blood monocytes in patients with a high viral load of hepatitis C virus genotype 1 showing substitution of amino Acid 70 in the core region. (PMID: 19955815) Ishii K. … Sumino Y. (Intervirology 2010) 23 25
  3. Induction of type 1 interferon receptor by zinc in U937 cells. (PMID: 19362011) Nagamine T. … Suzuki K. (Cytokine 2009) 3 23
  4. Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to interferon-alpha/5-fluorouracil combination therapy for hepatocellular carcinoma. (PMID: 19401692) Noda T. … Monden M. (Br. J. Cancer 2009) 3 23
  5. Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection. (PMID: 19714778) Gong Q.M. … Zhang X.X. (J. Viral Hepat. 2009) 3 23

Products for IFNAR2 Gene

Sources for IFNAR2 Gene

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