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IFNAR2 Gene

protein-coding   GIFtS: 66
GCID: GC21P034602

Interferon (Alpha, Beta And Omega) Receptor 2


(Previous symbol: IFNABR)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Interferon (Alpha, Beta And Omega) Receptor 21 2     Human Interferon Alpha,Beta Receptor11
IFNABR1 2 3     IFN-R2
Interferon Alpha Binding Protein2 3     IFN-alpha-REC2
Type I Interferon Receptor 22 3     Human Interferon Alpha/Beta Receptor2
IFN-R-22 3     Interferon Alpha/Beta Receptor 22
IFNARB2 3     Interferon-Alpha/Beta Receptor Beta Chain2
IFN-Alpha/Beta Receptor 22 3     IFN-Alpha Binding Protein3

External Ids:    HGNC: 54331   Entrez Gene: 34552   Ensembl: ENSG000001591107   OMIM: 6023765   UniProtKB: P485513   

Export aliases for IFNAR2 gene to outside databases

Previous GC identifers: GC21P031179 GC21P033522 GC21P033524 GC21P020067


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFNAR2 Gene:
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for
interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in
turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least
two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for IFNAR2 Gene:
IFNAR2 (interferon (alpha, beta and omega) receptor 2) is a protein-coding gene. Diseases associated with IFNAR2 include measles, and portal vein thrombosis. GO annotations related to this gene include protein kinase binding and type I interferon binding.

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551
Function: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta.
Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in
signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I
IFN receptor activity

Gene Wiki entry for IFNAR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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Regulatory elements:
   Regulatory transcription factor binding sites in the IFNAR2 gene promoter:
         STAT1   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNAR2 promoter sequence

   Search Chromatin IP Primers for IFNAR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNAR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
IFNAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNAR2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P034602:   GeneLoc Nature:405,311-319
Start:
34,602,206 bp from pter       20,179,027 bp from centromere
End:
34,637,980 bp from pter 20,211,701 bp from centromere
Size:
35,775 bases 32,675 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: X77722
genomic clones: pQ95D4 - pS318


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551 (See protein sequence)
Recommended Name: Interferon alpha/beta receptor 2 precursor  
Size: 515 amino acids; 57759 Da
Subunit: Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon
receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1
Selected PDB 3D structures from and Proteopedia for IFNAR2 (see all 9):
1N6U (3D)        1N6V (3D)        2HYM (3D)        2KZ1 (3D)        2LAG (3D)        3S8W (3D)    
Secondary accessions: A8KAJ4 D3DSE8 D3DSE9 Q15467 Q6FHD7
Alternative splicing: 3 isoforms:  P48551-1   P48551-2   P48551-3   (Soluble receptor)

Explore the universe of human proteins at neXtProt for IFNAR2: NX_P48551

Explore proteomics data for IFNAR2 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient
    to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many
    different cell types1
  • Glycosylated1
  • Glycosylation2 at Asn58, Asn87, Asn116, Asn188, Asn192
  • Modification sites at PhosphoSitePlus

  • See IFNAR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_000865.2  NP_001276054.1  NP_001276055.1  NP_001276057.1  NP_997467.1  NP_997468.1  

    ENSEMBL proteins: 
     ENSP00000371699   ENSP00000384309   ENSP00000343957   ENSP00000343289   ENSP00000371673  
     ENSP00000413160   ENSP00000403569   ENSP00000402311   ENSP00000398799   ENSP00000371676  
    Reactome Protein details: P48551

    IFNAR2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for IFNAR2
    OriGene Custom MassSpec
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    Novus Biologicals IFNAR2 Protein
    Novus Biologicals IFNAR2 Lysates
    Sino Biological Recombinant Protein for IFNAR2
    Sino Biological Cell Lysate for IFNAR2
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    Browse Proteins at Cloud-Clone Corp.

    IFNAR2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFN: Interferons

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interferon alpha/beta receptor 2
    Interferon receptor family

    3 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR015373 Interferon_alpha/beta_rcpt_bsu
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P48551

    ProtoNet protein and cluster: P48551

    UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551
    Similarity: Belongs to the type II cytokine receptor family


    IFNAR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INAR2_HUMAN, P48551
    Function: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta.
    Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in
    signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I
    IFN receptor activity

         Genatlas biochemistry entry for IFNAR2:
    interferon alpha/beta (type I) receptor,beta subunit,identified by monoclonal antibody IFNAR beta 1,cytokin
    receptor family II,member

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004905type I interferon receptor activity IDA7759950
    GO:0005515protein binding IPI11046044
    GO:0019901protein kinase binding IPI7759950
    GO:0019962type I interferon binding IPI7759950
         
    IFNAR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IFNAR2:
     Decreased influenza A/WSN/33 r 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ifnar2):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  tumorigenesis 

    IFNAR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ifnar2tm1Pjh for IFNAR2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFNAR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFNAR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNAR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNAR2

    miRNA
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    miRTarBase miRNAs that target IFNAR2:
    hsa-mir-484 (MIRT042241), hsa-mir-106b-5p (MIRT020448)

    Block miRNA regulation of human, mouse, rat IFNAR2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate IFNAR2:
    hsa-miR-30c hsa-miR-153 hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidIFNAR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFNAR2
    Predesigned siRNA for gene silencing in human, mouse, rat IFNAR2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IFNAR2

    Clone
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    OriGene ORF clones in mouse, rat for IFNAR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IFNAR2 (NM_207585)
    Sino Biological Human cDNA Clone for IFNAR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNAR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNAR2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IFNAR2 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNAR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INAR2_HUMAN, P48551: Isoform 1: Membrane; Single-pass type I membrane protein
    INAR2_HUMAN, P48551: Isoform 2: Membrane; Single-pass type I membrane protein
    INAR2_HUMAN, P48551: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS7588638
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA7759950

    IFNAR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFNAR2 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    2Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    Regulation of IFNA signaling0.69
    3Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    4Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    5TGF-Beta Pathway
    JAK-STAT Pathway0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IFNAR2
        THC Differentiation Pathway
    Interferon Pathway
    JAK-STAT Pathway

    1 GeneGo (Thomson Reuters) Pathway for IFNAR2
        Immune response IFN alpha/beta signaling pathway

    5 BioSystems Pathways for IFNAR2
        Interferon type I
    Toll-like receptor signaling pathway
    Regulation of Telomerase
    Downstream signaling in naive CD8+ T cells
    Regulation of toll-like receptor signaling pathway


    2 Reactome Pathways for IFNAR2
        Regulation of IFNA signaling
    Interferon alpha/beta signaling


    Selected Kegg Pathways  (Kegg details for IFNAR2) (see all 10):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    Jak-STAT signaling pathway


    IFNAR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNAR2: 
              Interferons & Receptors in human mouse rat
              Atherosclerosis in human mouse rat
              Type I Interferon Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IFNAR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFNAR2 (P485511, 2, 3 ENSP000003439574) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP18Q9UMW81, 2, 3, ENSP000002157944EBI-958408,EBI-356206 MINT-2729669 MINT-2729733 MINT-2729692 MINT-2729631 I2D: score=2 STRING: ENSP00000215794
    GNB2L1P632441, 3, ENSP000003660134EBI-958408,EBI-296739 I2D: score=6 STRING: ENSP00000366013
    STAT2P526301, 3, ENSP000003157684EBI-958408,EBI-1546963 I2D: score=5 STRING: ENSP00000315768
    JAK1P234581, 2, 3, ENSP000003432044EBI-958408,EBI-1383438 MINT-2729887 MINT-2729859 MINT-2729832 I2D: score=6 STRING: ENSP00000343204
    CREBBPQ927931, 3, ENSP000002623674EBI-958408,EBI-81215 I2D: score=4 STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007166cell surface receptor signaling pathway TAS8798579
    GO:0007259JAK-STAT cascade TAS7588638
    GO:0008283cell proliferation IEA--
    GO:0009615response to virus TAS7588638

    IFNAR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFNAR2 (INAR2)

    9 DrugBank Compounds for IFNAR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Interferon alfa-n3-- --targetagonist19955815 17139284 15898717 11752352 16953837 17016423
    Peginterferon alfa-2b-- 99210-65-8targetagonist19955815 17139284 15898717 11752352 16953837 17016423
    Interferon alfa-n1Interferon alpha-2 (see all 3)74899-72-2targetagonist10822464 19955815 17139284 11752352 17016423
    Interferon Alfa-2b, RecombinantInterferon alfa-2b (see all 2)99210-65-8targetbinder7584665 17139284 11752352 17016423
    Peginterferon alfa-2a-- 198153-51-4targetagonist19955815 15898717 11752352 16953837
    Interferon alfacon-1CIFN (see all 9)118390-30-0targetbinder11752352 12528473 8836913
    Interferon Alfa-2a, RecombinantInterferon alfa-2a (see all 3)77907-69-8target--18230610 15898717
    Interferon beta-1aFibroblast interferon (see all 3)145258-61-3target--11747625 16912135
    Interferon beta-1bFibroblast interferon (see all 3)145155-23-3targetagonist11752352 10049744

    8 Novoseek inferred chemical compound relationships for IFNAR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ifn-alpha 81.4 13 15287917 (5), 10777558 (1), 8628273 (1), 15287740 (1) (see all 7)
    2',5'-oligoadenylate 67.9 2 1694948 (1), 19381629 (1)
    tyrosine 48 15 7526154 (2), 9737924 (1), 8628273 (1), 9374471 (1) (see all 13)
    5fluorouracil 33.8 5 19401692 (1), 16101138 (1), 17300701 (1), 17088986 (1)
    alanine 6.61 1 10984492 (1)
    lipid 5.34 1 15312780 (1)
    phosphatidylinositol 0 1 9162009 (1)
    retinoic acid 0 1 12518169 (1)



    IFNAR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IFNAR2 gene (6 alternative transcripts): 
    NM_000874.4  NM_001289125.1  NM_001289126.1  NM_001289128.1  NM_207584.2  NM_207585.2  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382264 ENST00000404220(uc002yrb.3 uc002yrc.3 uc002yrd.3 uc002yre.3 uc002yrf.3)
    ENST00000342136 ENST00000420068 ENST00000342101 ENST00000382238 ENST00000413881
    ENST00000443073 ENST00000447980 ENST00000417007 ENST00000382241
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate IFNAR2:
    hsa-miR-30c hsa-miR-153 hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidIFNAR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IFNAR2
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    GenScript: all cDNA clones in your preferred vector (see all 3): IFNAR2 (NM_207585)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNAR2
    Primer
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    OriGene qPCR primer pairs and template standards for IFNAR2
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNAR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFNAR2
      QuantiTect SYBR Green Assays in human, mouse, rat IFNAR2
      QuantiFast Probe-based Assays in human, mouse, rat IFNAR2

    Selected AceView cDNA sequences (see all 186):

    CR541817 AA962667 BU753571 BQ710562 AI675225 CA309324 CR593774 BM677386 
    BX093020 AA356119 AI005041 BQ709397 CR599727 NM_000874 N39088 AI738554 
    AA234570 BC013156 CR596140 BE254594 CR603546 NM_207585 BQ022518 AA316831 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
    SP1:                                                        -     -                                               -           -     -                     
    SP2:                    -                                   -     -                             -                 -                                       
    SP3:                                                        -     -                             -                 -                                       
    SP4:                                                        -     -                             -                 -           -     -                     
    SP5:                                                        -     -                             -                 -     -     -     -                     


    ECgene alternative splicing isoforms for IFNAR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFNAR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGTCGGGGA
    IFNAR2 Expression
    About this image


    IFNAR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    IFNAR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFNAR2 Protein Expression

    UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551
    Tissue specificity: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in
    lymphoblastoid and fibrosarcoma cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNAR2: 
              Interferons & Receptors in human mouse rat
              Atherosclerosis in human mouse rat
              Type I Interferon Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFNAR2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifnar21 , 5 interferon (alpha and beta) receptor 21, 5 64.91(n)1
    49.59(a)1
      16 (52.82 cM)5
    159761  NM_010509.21  NP_034639.21 
     913727835 
    chicken
    (Gallus gallus)
    Aves IFNAR21 interferon (alpha, beta and omega) receptor 2 44.8(n)
    29.51(a)
      395664  NM_204858.1  NP_990189.1 
    lizard
    (Anolis carolinensis)
    Reptilia IFNAR26
    interferon (alpha, beta and omega) receptor 2
    22(a)
    1 ↔ 1
    GL343628.1(219059-252508)


    ENSEMBL Gene Tree for IFNAR2 (if available)
    TreeFam Gene Tree for IFNAR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    INAR2_HUMAN, P48551: Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection
    [MIM:610424]


    Selected SNPs for IFNAR2 (see all 908)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22292071,2,,4
    C,F,Hother125161061(+) TGCCTT/CCATCT 6 /S /F mis132Minor allele frequency- C:0.09MN EA NS WA NA EU 9693
    rs1387244071,2
    --25147112(+) GGGGAA/GTGGAG 3 -- us2k10--------
    rs126270391,2
    C,F,H--25147318(+) GCTGGG/TGCTAC 3 -- us2k13Minor allele frequency- T:0.50NA CSA 8
    rs48175521,2
    C,A,H--25147379(+) tttggG/Tatttt 3 -- us2k1 tfbs30--------
    rs122333381,2
    C,F--25147726(+) ATAAGT/CTCCCT 3 -- us2k110Minor allele frequency- C:0.17NA WA CSA EA 372
    rs1438410631,2
    C--25147741(+) ATCGTA/GTGGGG 3 -- us2k10--------
    rs284177421,2
    C--25147831(+) AAAGGA/GGTATC 3 -- us2k12Minor allele frequency- G:0.00NA 4
    rs1914050041,2
    --25147914(+) TCCTCA/CCTTTC 3 -- us2k10--------
    rs1475235411,2
    --25147994(+) TTTCCC/TTCTCC 3 -- us2k10--------
    rs1419533681,2
    C--25148103(+) TTTTC-/T/TT  
            
    TTTTT
    3 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFNAR2 (34602206 - 34637980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IFNAR2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723351CNV Deletion23290073
    esv990908CNV Deletion20482838
    esv2723349CNV Deletion23290073
    dgv4736n71CNV Loss21882294
    nsv913705CNV Loss21882294
    nsv913709CNV Loss21882294
    dgv4735n71CNV Loss21882294
    dgv4734n71CNV Loss21882294
    dgv4737n71CNV Loss21882294
    nsv913706CNV Loss21882294

    Human Gene Mutation Database (HGMD): IFNAR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNAR2
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNAR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602376   
    OMIM disorders: 610424  
    Selected diseases for IFNAR2 (see all 40):    
    About MalaCards
    measles    portal vein thrombosis    mumps    japanese encephalitis
    rubella    hepatitis c    hepatitis b    cblc
    dengue hemorrhagic fever    cervical intraepithelial neoplasia    hepatitis c virus    hemorrhagic fever
    multiple sclerosis    hepatocellular carcinoma    encephalitis    hepatitis
    bronchiolitis    fibrosarcoma    chronic myeloid leukemia    lung cancer susceptibility


    IFNAR2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for IFNAR2 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c chronic 50.7 11 14996348 (3), 12141824 (2), 12518169 (1), 11170061 (1) (see all 7)
    measles 38.3 2 10627547 (1), 18715339 (1)
    hepatitis c 37.5 8 12518169 (1), 11170061 (1), 9563926 (1), 15991303 (1) (see all 7)
    virus infection 36.3 3 9563926 (1), 12141824 (1)
    hepatocellular carcinoma 36.2 6 19401692 (1), 16953837 (1), 10853022 (1), 17572015 (1) (see all 6)
    multiple sclerosis 35.2 2 15885318 (2)
    carcinoma renal cell 19.2 3 10203606 (1), 10853333 (1), 17572016 (1)
    chronic liver disease 17.4 4 15991303 (1), 18583243 (1)
    response acute phase 8.94 1 9162009 (1)
    breast cancer 4.98 1 1827277 (1)

    Genetic Association Database (GAD): IFNAR2
    Human Genome Epidemiology (HuGE) Navigator: IFNAR2 (35 documents)

    Export disorders for IFNAR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFNAR2 gene, integrated from 10 sources (see all 249):
    (articles sorted by number of sources associating them with IFNAR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human interferon alpha/beta receptor: characterization and molecular cloning. (PubMed id 8181059)1, 2, 3, 9 Novick D.... Rubinstein M. (Cell 1994)
    2. IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. (PubMed id 15885318)1, 4, 9 Leyva L....Matesanz F. (J. Neuroimmunol. 2005)
    3. The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. (PubMed id 12842042)1, 2, 9 Chill J.H.... Anglister J. (Structure 2003)
    4. A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon I+. (PubMed id 20065083)1, 4, 9 Kreil S....Cross N.C. (Haematologica 2010)
    5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4, 9 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    6. IFNAR1 and IFNAR2 polymorphisms in patients with BehAset's disease. (PubMed id 19796549)1, 4, 9 Pay S....Dinc A. (Clin. Exp. Rheumatol. 2009)
    7. Multiple sclerosis and hepatitis C virus infection are associated with single nucleotide polymorphisms in interferon pathway genes. (PubMed id 18338947)1, 4, 9 Fortunato G....Sacchetti L. (amp 2008)
    8. Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. (PubMed id 18715339)1, 4, 9 Dhiman N....Poland G.A. (Tissue Antigens 2008)
    9. Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. (PubMed id 12618863)1, 4, 9 Sriram U....Oksenberg J.R. (Genes Immun. 2003)
    10. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. (PubMed id 7588638)1, 2, 9 Lutfalla G.... Uze G. (EMBO J. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3455 HGNC: 5433 AceView: IFNAR2 Ensembl:ENSG00000159110 euGenes: HUgn3455
    ECgene: IFNAR2 Kegg: 3455 H-InvDB: IFNAR2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFNAR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IFNAR2 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ifnar2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFNAR2 gene:
    Search GeneIP for patents involving IFNAR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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