Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFNAR2 Gene

protein-coding GIFtS: 64
GCID: GC21P034602

interferon (alpha, beta and omega) receptor 2

(Previous symbol: IFNABR)

Explore 39 diseases affiliated with
IFNAR2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
Interferon (Alpha, Beta And Omega) Receptor 2¹ ²		IFN-Alpha/Beta Receptor 2² ³
IFNABR¹ ² ³		Human Interferon Alpha,Beta Receptor11
Interferon Alpha Binding Protein² ³		IFN-R²
Type I Interferon Receptor 2² ³		IFN-Alpha-REC¹
IFN-R-2² ³		Human Interferon Alpha/Beta Receptor²
IFNARB² ³		Interferon Alpha/Beta Receptor 2²
IFN-Alpha Binding Protein² ³		Interferon-Alpha/Beta Receptor Beta Chain²

External Ids:	HGNC: 5433¹	Entrez Gene: 3455²	Ensembl: ENSG00000159110⁷	OMIM: 602376⁵	UniProtKB: P48551³

Export aliases for IFNAR2 gene to outside databases

Previous GC identifers: GC21P031179 GC21P033522 GC21P033524 GC21P020067

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNAR2:

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for

interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn

phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two

different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551

Function: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta.

Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal

transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN

receptor activity

Gene Wiki entry for IFNAR2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011512.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFNAR2 gene promoter:
STAT1 STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFNAR2 promoter sequence

Search SABiosciences Chromatin IP Primers for IFNAR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNAR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band: 21q22.11

IFNAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNAR2 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P034602:	GeneLoc	Nature:405,311-319
Start:	34,602,206 bp from pter	20,179,027 bp from centromere
End:	34,637,969 bp from pter	20,211,701 bp from centromere
Size:	35,764 bases	32,675 bases
Orientation:	plus strand	plus strand

Whole chromosome sequencing:
cDNA sequence:	X77722
genomic clones:	pQ95D4 - pS318

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551 (See protein sequence)

Recommended Name: Interferon alpha/beta receptor 2 precursor

Size: 515 amino acids; 57759 Da

Subunit: Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon

receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1

Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Membrane; Single-pass type I membrane protein

Subcellular location: Isoform 3: Secreted

6/9 PDB 3D structures from and Proteopedia for IFNAR2 (see all 9):

1N6U (3D)

1N6V (3D)

2HYM (3D)

2KZ1 (3D)

2LAG (3D)

3S8W (3D)

Secondary accessions: A8KAJ4 D3DSE8 D3DSE9 Q15467 Q6FHD7

Alternative splicing: 3 isoforms: P48551-1 P48551-2 P48551-3 (Soluble receptor)

Explore the universe of human proteins at neXtProt for IFNAR2: NX_P48551

Post-translational modifications:

Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to

mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many

different cell types¹

Glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P48551

IFNAR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000865.2 NP_997467.1 NP_997468.1

ENSEMBL proteins:

ENSP00000371699 ENSP00000384309 ENSP00000343957 ENSP00000343289 ENSP00000371673

ENSP00000413160 ENSP00000403569 ENSP00000402311 ENSP00000398799 ENSP00000371676

Reactome Protein details: P48551
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IFNAR2 (IFN-alpha/beta R2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): IFNAR2 OriGene Custom Protein Services for IFNAR2
	GenScript Custom Purified and Recombinant Proteins Services for IFNAR2
	Novus Biologicals IFNAR2 Protein Novus Biologicals IFNAR2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	7588638
GO:0005615	extracellular space	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IDA	7759950

IFNAR2 for ontologies About GeneDecksing

IFNAR2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for IFNAR2 (IFN-alpha/beta R2)
	Browse OriGene Antibodies OriGene Custom Antibody Services for IFNAR2
	GenScript Custom Superior Antibodies Services for IFNAR2
	Novus Biologicals IFNAR2 Antibodies
	Search for Antibodies for IFNAR2 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for IFNAR2

Assay Products for IFNAR2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IFNAR2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFNAR2 for domains About GeneDecksing

3 InterPro domains/families:

IPR003961 Fibronectin_type3

IPR015373 Interferon_alpha/beta_rcpt_bsu

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry P48551

ProtoNet protein and cluster: P48551

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551

Similarity: Belongs to the type II cytokine receptor family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551

Function: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta.

Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal

transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN

receptor activity

Genatlas biochemistry entry for IFNAR2:

interferon alpha/beta (type I) receptor,beta subunit,identified by monoclonal antibody IFNAR beta 1,cytokin receptor

family II,member

miRNA Products:		OriGene 3'-UTR Clone (see all 3): IFNAR2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNAR2
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNAR2:
		hsa-miR-30c hsa-miR-153 hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
		SwitchGear 3'UTR luciferase reporter plasmid: IFNAR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNAR2 (see all 4) OriGene shRNA RFP: IFNAR2 OriGene siRNA: IFNAR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNAR2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IFNAR2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNAR2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNAR2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): IFNAR2 (NM_207585)
		Sino Biological Human cDNA Clone for IFNAR2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNAR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNAR2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IFNAR2
		Search LifeMap BioReagents cell lines for IFNAR2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNAR2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004905	type I interferon receptor activity	IDA	7759950
GO:0005515	protein binding	IPI	17923090
GO:0019901	protein kinase binding	IPI	7759950
GO:0019962	type I interferon binding	IPI	7759950

IFNAR2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IFNAR2:

Decreased influenza A/WSN/33 r

Animal Models:
Mouse knock-out Ifnar2^tm1Pjh for IFNAR2
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ifnar2):

hematopoietic system

homeostasis/metabolism

immune system

mortality/aging

tumorigenesis

IFNAR2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of IFNA signaling

	Regulation of IFNA signaling	1.00			Immune response IFN alpha/beta signaling pathway	0.71
	Immune response_IFN alpha/beta signaling pathway	0.71

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Toll-like receptor signaling pathway

Toll-like receptor signaling pathway

1.00

Toll-like receptor signaling pathway

0.97

Measles

Measles

1.00

Influenza A

0.35

Immune System

Immune System

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IFNAR2

Immune response IFN alpha/beta signaling pathway

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNAR2

	THC Differentiation Pathway
	Interferon Pathway
	JAK-STAT Pathway

1 GeneGo (Thomson Reuters) Pathway for IFNAR2

Immune response IFN alpha/beta signaling pathway

3 BioSystems Pathways for IFNAR2

	Toll-like receptor signaling pathway
	Regulation of Telomerase
	Downstream signaling in naive CD8+ T cells

5 Reactome Pathways for IFNAR2

	Regulation of IFNA signaling
	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	Interferon Signaling
	Immune System

5/8 Kegg Pathways (Kegg details for IFNAR2) (see all 8):

	Cytokine-cytokine receptor interaction
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	Jak-STAT signaling pathway
	Natural killer cell mediated cytotoxicity

IFNAR2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IFNAR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/51 Interacting proteins for IFNAR2 (P48551^{1, 2, 3} ENSP00000343957⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
USP18	Q9UMW8²^,³, ENSP00000215794⁴	MINT-2729669 MINT-2729733 MINT-2729692 MINT-2729631 I2D: score=2 STRING: ENSP00000215794
GNB2L1	P63244¹^,³, ENSP00000366013⁴	EBI-958408,EBI-2559282 I2D: score=6 STRING: ENSP00000366013
STAT2	P52630¹^,³, ENSP00000315768⁴	EBI-958408,EBI-1546963 I2D: score=5 STRING: ENSP00000315768
JAK1	P23458²^,³, ENSP00000343204⁴	MINT-2729887 MINT-2729859 MINT-2729832 I2D: score=6 STRING: ENSP00000343204
IRF9	Q00978¹^,³, ENSP00000380073⁴	EBI-958408,EBI-626526 I2D: score=6 STRING: ENSP00000380073

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0007166	cell surface receptor signaling pathway	TAS	8798579
GO:0007259	JAK-STAT cascade	TAS	7588638
GO:0008283	cell proliferation	IEA	--
GO:0009615	response to virus	TAS	7588638

IFNAR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IFNAR2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNAR2

9 DrugBank Compounds for IFNAR2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Interferon alfa-n3	--	--	target	agonist	19955815 17139284 15898717 11752352 16953837 17016423
Peginterferon alfa-2b	--	99210-65-8	target	agonist	19955815 17139284 15898717 11752352 16953837 17016423
Interferon alfa-n1	Interferon alpha-2 (see all 3)	74899-72-2	target	agonist	10822464 19955815 17139284 11752352 17016423
Interferon Alfa-2b, Recombinant	Interferon alfa-2b (see all 2)	99210-65-8	target	binder	7584665 17139284 11752352 17016423
Peginterferon alfa-2a	--	198153-51-4	target	agonist	19955815 15898717 11752352 16953837
Interferon alfacon-1	CIFN (see all 9)	118390-30-0	target	binder	11752352 12528473 8836913
Interferon Alfa-2a, Recombinant	Interferon alfa-2a (see all 3)	77907-69-8	target	--	18230610 15898717
Interferon beta-1a	Fibroblast interferon (see all 3)	145258-61-3	target	--	11747625 16912135
Interferon beta-1b	Fibroblast interferon (see all 3)	145155-23-3	target	agonist	11752352 10049744

8 Novoseek chemical compound relationships for IFNAR2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ifn-alpha	81.4	13	15287917 (5), 10777558 (1), 8628273 (1), 15287740 (1) (see all 7)
2',5'-oligoadenylate	67.9	2	1694948 (1), 19381629 (1)
tyrosine	48	15	7526154 (2), 9737924 (1), 8628273 (1), 9374471 (1) (see all 13)
5fluorouracil	33.8	5	19401692 (1), 16101138 (1), 17300701 (1), 17088986 (1)
alanine	6.61	1	10984492 (1)
lipid	5.34	1	15312780 (1)
phosphatidylinositol	0	1	9162009 (1)
retinoic acid	0	1	12518169 (1)

Search CenterWatch for drugs/clinical trials and news about IFNAR2 / INAR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNAR2 gene (3 alternative transcripts):

NM_000874.3 NM_207584.1 NM_207585.1

Unigene Cluster for IFNAR2:

Interferon (alpha, beta and omega) receptor 2

Hs.708195 [show with all ESTs]

Unigene Representative Sequence: L41944

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000382264 ENST00000404220(uc002yrb.3 uc002yrc.3 uc002yrd.3 uc002yre.3 uc002yrf.3)

ENST00000342136 ENST00000420068 ENST00000342101 ENST00000382238 ENST00000413881

ENST00000443073 ENST00000447980 ENST00000417007 ENST00000382241

miRNA Products:		OriGene 3'-UTR Clone (see all 3): IFNAR2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNAR2
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNAR2:
		hsa-miR-30c hsa-miR-153 hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
		SwitchGear 3'UTR luciferase reporter plasmid: IFNAR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNAR2 (see all 4) OriGene shRNA RFP: IFNAR2 OriGene siRNA: IFNAR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNAR2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNAR2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNAR2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): IFNAR2 (NM_207585)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNAR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNAR2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNAR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IFNAR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNAR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNAR2

Additional cDNA sequence:

AK293059.1 BC002793.2 BC013156.1 CR541817.1 L41942.1 L41943.1 L41944.1 U29584.1

X77722.1 X89772.1 X89814.1

10 DOTS entries:

DT.92467568 DT.92467560 DT.86852545 DT.100025296 DT.95107171 DT.100782879 DT.95148855 DT.100782885

DT.121132950 DT.97790884

24/186 AceView cDNA sequences (see all 186):

NM_207585 CR603546 AI675225 BU753571 BI253289 NM_000874 BQ710562 NM_207584

BX093020 AA356119 CR596140 AA029587 BQ709397 AI738554 CR611634 BF982421

CR541817 CR593774 CR599727 X89772 N39088 AA962667 AA425115 BC013156

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR2 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14a	·	14b	·	14c
SP1:																			-		-																-				-		-
SP2:							-												-		-										-						-
SP3:																			-		-										-						-
SP4:																			-		-										-						-				-		-
SP5:																			-		-										-						-		-		-		-

ECgene alternative splicing isoforms for IFNAR2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNAR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGTCGGGGA

About this image

IFNAR2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IFNAR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNAR2

SOURCE GeneReport for Unigene cluster: Hs.708195

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551

Tissue specificity: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in

lymphoblastoid and fibrosarcoma cell lines

SABiosciences Expression via Pathway-Focused PCR Arrays including IFNAR2:

Interferons & Receptors in human mouse rat

Atherosclerosis in human mouse rat

Type I Interferon Response in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNAR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IFNAR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNAR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNAR2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNAR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFNAR2 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ifnar2^{1 , 5}	interferon (alpha and beta) receptor 2^{1, 5}	65.09(n)¹ 50.41(a)¹		16 (52.82 cM)⁵ 15976¹ NM_010509.2¹ NP_034639.2¹ 91372783⁵
chicken (Gallus gallus)	Aves	IFNAR2¹	interferon (alpha, beta and omega) receptor 2	43.92(n) 28.14(a)		395664 NM_204858.1 NP_990189.1

ENSEMBL Gene Tree for IFNAR2 (if available)
TreeFam Gene Tree for IFNAR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551

Polymorphism: Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424]

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2229207^1,2	C,F,H,	other	34614250(+)	`TGCCTT/CCATCT`	6	/S /F	mis¹		32		MN EA NS WA NA EU	9693
rs14861^1,2	C,H	--	20102043(+)	`CTCCTG/ACAATT`	1	--	us2k¹ ese³		9		MN EA NS	874
rs17860265^1,2	C,F,	--	20102349(+)	`GGGGGG/AGTGTG`	1	--	us2k¹		6		NS NA MN	760
rs45582733^1,2	F	--	20102584(+)	`GCCCAG/TGAAGC`	1	--	us2k¹		1		MN	502
rs45482393^1,2	F	--	20102590(+)	`GAAGCG/AGAGGT`	1	--	us2k¹		1		MN	540
rs3191758^1,2	F,	--	20102623(+)	`ACTGCA/C/GCTTCA`	1	--	us2k¹		2		MN NA	504
rs138724407^1,2		--	34600302(+)	`GGGGAA/GTGGAG`	3	--	us2k¹		0	--	--	--	--
rs12627039^1,2	C,F,H,	--	34600508(+)	`GCTGGG/TGCTAC`	3	--	us2k¹		3		NA CSA	8
rs4817552^1,2	C,A,H	--	34600569(+)	`tttggG/Tatttt`	3	--	us2k¹ tfbs³		0	--	--	--	--
rs12233338^1,2	C,F,	--	34600916(+)	`ATAAGT/CTCCCT`	3	--	us2k¹		10		NA WA CSA EA	372

HapMap Linkage Disequilibrium report for IFNAR2 (34602206 - 34637969 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFNAR2: --
Human Gene Mutation Database (HGMD): IFNAR2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNAR2

DNA2.0 Custom Variant and Variant Library Synthesis for IFNAR2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IFNAR2 for disorders           About GeneDecksing

OMIM gene information: 602376
OMIM disorders: 610424
20/39 diseases for IFNAR2 (see all 39):    About MalaCards

portal vein thrombosis dengue hemorrhagic fever cervical intraepithelial neoplasia hemorrhagic fever

japanese encephalitis hepatitis b hepatitis c multiple sclerosis

chronic myeloid leukemia myeloid leukemia mumps measles

bronchiolitis liver disease renal cell carcinoma cblc

rubella thrombosis hepatitis hepatocellular carcinoma

10/18 Novoseek disease relationships for IFNAR2 gene (see all 18) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis c chronic	50.7	11	14996348 (3), 12141824 (2), 12518169 (1), 11170061 (1) (see all 7)
measles	38.3	2	10627547 (1), 18715339 (1)
hepatitis c	37.5	8	12518169 (1), 11170061 (1), 9563926 (1), 15991303 (1) (see all 7)
virus infection	36.3	3	9563926 (1), 12141824 (1)
hepatocellular carcinoma	36.2	6	19401692 (1), 16953837 (1), 10853022 (1), 17572015 (1) (see all 6)
multiple sclerosis	35.2	2	15885318 (2)
carcinoma renal cell	19.2	3	10203606 (1), 10853333 (1), 17572016 (1)
chronic liver disease	17.4	4	15991303 (1), 18583243 (1)
response acute phase	8.94	1	9162009 (1)
breast cancer	4.98	1	1827277 (1)

Genetic Association Database (GAD): IFNAR2
Human Genome Epidemiology (HuGE) Navigator: IFNAR2 (35 documents)

Export disorders for IFNAR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFNAR2 gene, integrated from 9 sources (see all 244):
(articles sorted by number of sources associating them with IFNAR2)

Utopia: connect your pdf to the dynamic
world of online information

The human interferon alpha/beta receptor: characterization and molecular cloning. (PubMed id 8181059)^{1, 2, 3, 9} Novick D.... Rubinstein M. (1994)
IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. (PubMed id 15885318)^{1, 4, 9} Leyva L....Matesanz F. (2005)
The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. (PubMed id 12842042)^{1, 2, 9} Chill J.H.... Anglister J. (2003)
Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. (PubMed id 12618863)^{1, 4, 9} Sriram U....Oksenberg J.R. (2003)
Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. (PubMed id 7588638)^{1, 2, 9} Lutfalla G.... Uze G. (1995)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues. (PubMed id 12105218)^{1, 2} Velichko S....Croze E. (2002)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation. (PubMed id 10049744)^{2, 7} Russell-Harde D....Croze E. (1999)
Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. (PubMed id 9121453)^{1, 2} Li X....Stark G.R. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3455	HGNC: 5433	AceView: IFNAR2	Ensembl:ENSG00000159110	euGenes: HUgn3455
ECgene: IFNAR2	Kegg: 3455	H-InvDB: IFNAR2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFNAR2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IFNAR2	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/ifnar2/

Intellectual Property for IFNAR2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IFNAR2 gene:
Search GeneIP for patents involving IFNAR2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for IFNAR2 (IFN-alpha/beta R2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for IFNAR2 (IFN-alpha/beta R2)

	Browse OriGene Antibodies		OriGene shRNA RFP for IFNAR2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNAR2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNAR2
	OriGene Protein Over-expression Lysate for IFNAR2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for IFNAR2		OriGene 3'-UTR Clone for IFNAR2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNAR2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNAR2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for IFNAR2		OriGene Custom Protein Services for IFNAR2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNAR2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNAR2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNAR2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNAR2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNAR2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNAR2

	GenScript Custom Purified and Recombinant Proteins Services for IFNAR2		GenScript cDNA clones with any tag delivered in your preferred vector for IFNAR2
	GenScript Custom Assay Services for IFNAR2		GenScript Custom Superior Antibodies Services for IFNAR2
	GenScript Custom overexpressing Cell Line Services for IFNAR2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in IFNAR2 promoter
	Search Chromatin IP Primers for IFNAR2
	RT² qPCR Primer Assay in human, mouse, rat IFNAR2
	GNC Network for IFNAR2
	SABiosciences PCR Arrays including human, mouse, rat IFNAR2

Search Tocris compounds for IFNAR2

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for IFNAR2
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	IFNAR2 antibodies
	IFNAR2 proteins
	IFNAR2 lysates

	Search for Antibodies for IFNAR2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for IFNAR2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for IFNAR2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNAR2

	SwitchGear 3'UTR luciferase reporter plasmids for IFNAR2
	SwitchGear Promoter luciferase reporter plasmids for IFNAR2

Search ThermoFisher Antibodies for IFNAR2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNAR2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IFNAR2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

IFNAR2 Gene

interferon (alpha, beta and omega) receptor 2

Aliases
for IFNAR2 gene

Summaries
for IFNAR2 gene

Genomic Views
for IFNAR2 gene

Proteins
for IFNAR2 gene

Protein Domains /
Families
for IFNAR2 gene

Function
for IFNAR2 gene

Pathways & Interactions
for IFNAR2 gene

Drugs & Compounds
for IFNAR2 gene

Transcripts
for IFNAR2 gene

Expression
for IFNAR2 gene

Orthologs
for IFNAR2 gene

Paralogs
for IFNAR2 gene

Genomic Variants
for IFNAR2 gene

Disorders / Diseases
for IFNAR2 gene

Publications
for IFNAR2 gene

External Searches for IFNAR2 gene

Genome Databases showing IFNAR2 gene

Other Databases showing IFNAR2 gene

Specialized Databases showing IFNAR2 gene

Intellectual Property
for IFNAR2 gene

Products
for IFNAR2 gene

View Random Gene

Advanced Search

Export list of displayed genes

IFNAR2 Gene

interferon (alpha, beta and omega) receptor 2

Aliasesfor IFNAR2 gene

Summariesfor IFNAR2 gene

Genomic Viewsfor IFNAR2 gene

Proteinsfor IFNAR2 gene

Protein Domains /Familiesfor IFNAR2 gene

Functionfor IFNAR2 gene

Pathways & Interactionsfor IFNAR2 gene

Drugs & Compoundsfor IFNAR2 gene

Transcriptsfor IFNAR2 gene

Expression for IFNAR2 gene

Orthologsfor IFNAR2 gene

Paralogsfor IFNAR2 gene

Genomic Variantsfor IFNAR2 gene

Disorders / Diseasesfor IFNAR2 gene

Publicationsfor IFNAR2 gene

External Searches for IFNAR2 gene

Genome Databases showing IFNAR2 gene

Other Databases showing IFNAR2 gene

Specialized Databases showing IFNAR2 gene

Intellectual Propertyfor IFNAR2 gene

Productsfor IFNAR2 gene

View Random Gene

Aliases
for IFNAR2 gene

Summaries
for IFNAR2 gene

Genomic Views
for IFNAR2 gene

Proteins
for IFNAR2 gene

Protein Domains /
Families
for IFNAR2 gene

Function
for IFNAR2 gene

Pathways & Interactions
for IFNAR2 gene

Drugs & Compounds
for IFNAR2 gene

Transcripts
for IFNAR2 gene

Expression
for IFNAR2 gene

Orthologs
for IFNAR2 gene

Paralogs
for IFNAR2 gene

Genomic Variants
for IFNAR2 gene

Disorders / Diseases
for IFNAR2 gene

Publications
for IFNAR2 gene

Intellectual Property
for IFNAR2 gene

Products
for IFNAR2 gene