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Aliases for IFNAR2 Gene

Aliases for IFNAR2 Gene

  • Interferon (Alpha, Beta And Omega) Receptor 2 2 3
  • Interferon Alpha Binding Protein 3 4
  • Type I Interferon Receptor 2 3 4
  • IFN-Alpha/Beta Receptor 2 3 4
  • IFN-R-2 3 4
  • IFNABR 3 4
  • IFNARB 3 4
  • Interferon-Alpha/Beta Receptor Beta Chain 3
  • Human Interferon Alpha/Beta Receptor 3
  • Interferon Alpha/Beta Receptor 2 3
  • IFN-Alpha Binding Protein 4
  • IFN-Alpha-REC 3
  • IFN-R 3

External Ids for IFNAR2 Gene

Previous Symbols for IFNAR2 Gene

  • IFNABR

Summaries for IFNAR2 Gene

Entrez Gene Summary for IFNAR2 Gene

  • The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNAR2 Gene

IFNAR2 (Interferon (Alpha, Beta And Omega) Receptor 2) is a Protein Coding gene. Diseases associated with IFNAR2 include measles and hepatocellular carcinoma. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein kinase binding and type I interferon binding.

UniProtKB/Swiss-Prot for IFNAR2 Gene

  • Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.

Gene Wiki entry for IFNAR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNAR2 Gene

Genomics for IFNAR2 Gene

Genomic Location for IFNAR2 Gene

Start:
33,229,895 bp from pter
End:
33,265,675 bp from pter
Size:
35,781 bases
Orientation:
Plus strand

Genomic View for IFNAR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNAR2 Gene

Regulatory Elements for IFNAR2 Gene

Transcription factor binding sites by QIAGEN in the IFNAR2 gene promoter:

Proteins for IFNAR2 Gene

  • Protein details for IFNAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48551-INAR2_HUMAN
    Recommended name:
    Interferon alpha/beta receptor 2
    Protein Accession:
    P48551
    Secondary Accessions:
    • A8KAJ4
    • D3DSE8
    • D3DSE9
    • Q15467
    • Q6FHD7

    Protein attributes for IFNAR2 Gene

    Size:
    515 amino acids
    Molecular mass:
    57759 Da
    Quaternary structure:
    • Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1.

    Three dimensional structures from OCA and Proteopedia for IFNAR2 Gene

    Alternative splice isoforms for IFNAR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFNAR2 Gene

Proteomics data for IFNAR2 Gene at MOPED

Post-translational modifications for IFNAR2 Gene

  • Glycosylated.
  • Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn58, Asn87, Asn116, Asn188, and Asn192

No data available for DME Specific Peptides for IFNAR2 Gene

Domains for IFNAR2 Gene

Gene Families for IFNAR2 Gene

Protein Domains for IFNAR2 Gene

UniProtKB/Swiss-Prot:

INAR2_HUMAN
Family:
  • Belongs to the type II cytokine receptor family.:
    • P48551
genes like me logo Genes that share domains with IFNAR2: view

Function for IFNAR2 Gene

Molecular function for IFNAR2 Gene

GENATLAS Biochemistry: interferon alpha/beta (type I) receptor,beta subunit,identified by monoclonal antibody IFNAR beta 1,cytokin receptor family II,member
UniProtKB/Swiss-Prot Function: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.

Gene Ontology (GO) - Molecular Function for IFNAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004905 type I interferon receptor activity IDA 7759950
GO:0005515 protein binding IPI 11046044
GO:0019901 protein kinase binding IPI 7759950
GO:0019962 type I interferon binding IPI 7759950
genes like me logo Genes that share ontologies with IFNAR2: view
genes like me logo Genes that share phenotypes with IFNAR2: view

Animal Models for IFNAR2 Gene

MGI Knock Outs for IFNAR2:

miRNA for IFNAR2 Gene

miRTarBase miRNAs that target IFNAR2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IFNAR2 Gene

Localization for IFNAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNAR2 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNAR2 Gene COMPARTMENTS Subcellular localization image for IFNAR2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IFNAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 7588638
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 7759950
genes like me logo Genes that share ontologies with IFNAR2: view

Pathways for IFNAR2 Gene

genes like me logo Genes that share pathways with IFNAR2: view

Gene Ontology (GO) - Biological Process for IFNAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0007166 cell surface receptor signaling pathway TAS 8798579
GO:0007259 JAK-STAT cascade TAS 7588638
GO:0008283 cell proliferation IEA --
GO:0009615 response to virus TAS 7588638
genes like me logo Genes that share ontologies with IFNAR2: view

Compounds for IFNAR2 Gene

(9) Drugbank Compounds for IFNAR2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Interferon Alfa-2a, Recombinant
  • Interferon alfa-2a
77907-69-8 target
Interferon Alfa-2b, Recombinant
  • Interferon alfa-2b
99210-65-8 target binder
Interferon alfacon-1
  • CIFN
118390-30-0 target binder
Interferon alfa-n1
  • Interferon alpha-2
74899-72-2 target agonist
Interferon alfa-n3
target agonist

(8) Novoseek inferred chemical compound relationships for IFNAR2 Gene

Compound -log(P) Hits PubMed IDs
ifn-alpha 81.4 11
2,5-oligoadenylate 67.9 2
tyrosine 48 14
5fluorouracil 33.8 4
alanine 6.61 1
genes like me logo Genes that share compounds with IFNAR2: view

Transcripts for IFNAR2 Gene

Unigene Clusters for IFNAR2 Gene

Interferon (alpha, beta and omega) receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: -
SP7: -
SP8: -
SP9: - -

Relevant External Links for IFNAR2 Gene

GeneLoc Exon Structure for
IFNAR2
ECgene alternative splicing isoforms for
IFNAR2

Expression for IFNAR2 Gene

mRNA expression in normal human tissues for IFNAR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFNAR2 Gene

This gene is overexpressed in Whole Blood (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFNAR2 Gene

SOURCE GeneReport for Unigene cluster for IFNAR2 Gene Hs.708195

mRNA Expression by UniProt/SwissProt for IFNAR2 Gene

P48551-INAR2_HUMAN
Tissue specificity: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
genes like me logo Genes that share expressions with IFNAR2: view

Orthologs for IFNAR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNAR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNAR2 36
  • 98.58 (n)
  • 97.86 (a)
IFNAR2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFNAR2 36
  • 73.29 (n)
  • 59.25 (a)
IFNAR2 37
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 58 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
IFNAR2 36
  • 73.59 (n)
  • 59.61 (a)
mouse
(Mus musculus)
Mammalia Ifnar2 36
  • 64.91 (n)
  • 49.59 (a)
Ifnar2 16
Ifnar2 37
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IFNAR2 37
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFNAR2 37
  • 30 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifnar2 36
  • 66.67 (n)
  • 50.92 (a)
chicken
(Gallus gallus)
Aves IFNAR2 36
  • 44.8 (n)
  • 29.51 (a)
IFNAR2 37
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFNAR2 37
  • 22 (a)
OneToOne
Species with no ortholog for IFNAR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNAR2 Gene

ENSEMBL:
Gene Tree for IFNAR2 (if available)
TreeFam:
Gene Tree for IFNAR2 (if available)

Paralogs for IFNAR2 Gene

No data available for Paralogs for IFNAR2 Gene

Variants for IFNAR2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNAR2 Gene

P48551-INAR2_HUMAN
Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424]

Sequence variations from dbSNP and Humsavar for IFNAR2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs1187 -- 33,238,588(-) GTCAT(A/C)ATCAG intron-variant
rs3153 -- 33,237,200(-) TGTGG(C/T)CTCTG intron-variant
rs9710 -- 33,262,623(+) GCACT(A/G)CAGTC reference, synonymous-codon, intron-variant
rs1051393 - 33,241,950(+) TCATC(A/G/T)TCAGA missense, reference
rs1131668 -- 33,262,573(+) gtctc(A/G)ctaag missense, reference, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFNAR2 Gene

Variant ID Type Subtype PubMed ID
dgv4734n71 CNV Loss 21882294
dgv4735n71 CNV Loss 21882294
nsv913705 CNV Loss 21882294
nsv913706 CNV Loss 21882294
esv2723349 CNV Deletion 23290073
esv990908 CNV Deletion 20482838
esv2723351 CNV Deletion 23290073
dgv4736n71 CNV Loss 21882294
nsv913709 CNV Loss 21882294
dgv4737n71 CNV Loss 21882294
nsv913714 CNV Gain 21882294

Relevant External Links for IFNAR2 Gene

HapMap Linkage Disequilibrium report
IFNAR2
Human Gene Mutation Database (HGMD)
IFNAR2

Disorders for IFNAR2 Gene

(1) OMIM Diseases for IFNAR2 Gene (602376)

(18) Novoseek inferred disease relationships for IFNAR2 Gene

Disease -log(P) Hits PubMed IDs
hepatitis c chronic 50.7 10
measles 38.3 2
hepatitis c 37.5 7
virus infection 36.3 2
hepatocellular carcinoma 36.2 6

Relevant External Links for IFNAR2

Genetic Association Database (GAD)
IFNAR2
Human Genome Epidemiology (HuGE) Navigator
IFNAR2
genes like me logo Genes that share disorders with IFNAR2: view

No data available for UniProtKB/Swiss-Prot for IFNAR2 Gene

Publications for IFNAR2 Gene

  1. The human interferon alpha/beta receptor: characterization and molecular cloning. (PMID: 8181059) Novick D. … Rubinstein M. (Cell 1994) 2 3 4 23
  2. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. (PMID: 7588638) Lutfalla G. … Uze G. (EMBO J. 1995) 3 4 23
  3. The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. (PMID: 12842042) Chill J.H. … Anglister J. (Structure 2003) 3 4 23
  4. IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. (PMID: 15885318) Leyva L. … Matesanz F. (J. Neuroimmunol. 2005) 3 23 49
  5. Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. (PMID: 18715339) Dhiman N. … Poland G.A. (Tissue Antigens 2008) 3 23 49

Products for IFNAR2 Gene

Sources for IFNAR2 Gene

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