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IFNAR2 Gene

protein-coding GIFtS: 69

GC21P033524

interferon (alpha, beta and omega) receptor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IFNABR)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
IFN-R ^², ³
IFN-alpha-REC ^², ³
IFNABR ^², ³
IFNARB ^², ³
OTTHUMP00000067674 ^²
OTTHUMP00000067676 ^²

Descriptions
Interferon alpha/beta receptor 2 ^², ³
Type I interferon receptor ^², ³
human interferon alpha,beta receptor ⁹
human interferon alpha/beta receptor ^²
interferon (alpha, beta and omega) receptor 2 ^²
interferon-alpha/beta receptor beta chain ^²

External Ids
HGNC: 5433¹
Entrez Gene: 3455²
UniProtKB: P48551³
Ensembl: ENSG00000159110⁷

Search outside databases for aliases for IFNAR2 gene

Previous GC identifers: GC21P031179 GC21P033522

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IFNAR2:

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a

receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus

protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple

transcript variants encoding at least two different isoforms have been found for this gene.

[provided by RefSeq]

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551

Function: Receptor for interferons alpha and beta. Isoform 1 and isoform 3 are directly involved in

signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts

with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN

activity

Gene Wiki entry for IFNAR2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.1|21q22.11 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band: 21q22.11

IFNAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P033524:	GeneLoc	Nature:405,311-319
Start:	33,524,101 bp from pter	20,179,027 bp from centromere
End:	33,558,700 bp from pter	20,211,701 bp from centromere
Size:	34,600 bases	32,675 bases
Orientation:	plus strand	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	X77722
genomic clones:	pQ95D4 - pS318

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551 (See protein sequence)

Recommended Name: Interferon-alpha/beta receptor beta chain precursor

Size: 515 amino acids; 57759 Da

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structure from and Proteopedia :

1N6U (3D)

1N6V (3D)

Alternative splicing: 3 isoforms: P48551-1 P48551-2 P48551-3

Post-translational modifications:

Upon binding, it is phosphorylated on tyrosine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000865.2 NP_997467.1 NP_997468.1

ENSEMBL proteins:

ENSP00000371673 ENSP00000316407 ENSP00000384309 ENSP00000371699 ENSP00000343289 ENSP00000343957

ENSP00000371676

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IFNAR2 (IFN-alpha/beta R2, IFN-gamma R1/CD119)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IFN alpha/beta Receptor beta, IFNAR2)
	Human Recombinant Proteins from Abnova (IFNAR2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	7588638
GO:0005615	extracellular space	IEA	--
GO:0005886	plasma membrane	TAS	8969169
GO:0005887	integral to plasma membrane	TAS	7588638

About this table

Antibodies for IFNAR2:

	Invitrogen Antibodies for IFNAR2
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for IFNAR2 (IFN-alpha/beta R2, IFN-gamma R1/CD119)
	Antibodies from Abcam (IFN alpha/beta Receptor beta, IFNAR2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IFNAR2)
	Novus Biologicals Antibodies for IFNAR2

Assays for IFNAR2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for IFNAR2 (IFN-gamma R1/CD119) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P48551

ProtoNet protein and cluster: P48551

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551

Similarity: Belongs to the type II cytokine receptor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFNAR2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IFNAR2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000874

Applied Biosystems Silencer® siRNAs for IFNAR2

Sigma-Aldrich siRNA and siRNA Panels for IFNAR2

Sigma-Aldrich shRNA Panels and shRNA for IFNAR2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IFNAR2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000874
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000874
untagged cDNA clones in CMV expression vector (see all 3): NM_000874

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_207585

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551

Function: Receptor for interferons alpha and beta. Isoform 1 and isoform 3 are directly involved in

signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts

with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN

activity

Genatlas biochemistry entry for IFNAR2:

interferon alpha/beta (type I) receptor,beta subunit,identified by monoclonal antibody IFNAR beta

1,cytokin receptor family II,member

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ifnar2):

hematopoietic system

homeostasis/metabolism

immune system

tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004905	type I interferon receptor activity	TAS	8798579
GO:0005515	protein binding	IPI	11046044 17923090

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for IFNAR2 (Your Favorite Gene powered by Ingenuity)

Hepatic Fibrosis / Hepatic Stellate Cell Activation
Interferon Signaling

GeneDecks IFNAR2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IFNAR2

5/55 Interacting proteins for IFNAR2 (ENSP00000371676³ P48551^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 55 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STAT2	P52630¹	STRING (score=.999) EBI-958408, EBI-1546963
USP18	Q9UMW8²	STRING (score=.987) MINT-2729669 MINT-2729733 MINT-2729692 MINT-2729631
CREBBP	Q92793¹	EBI-958408, EBI-81215
EP300	Q09472¹	EBI-958408, EBI-447295
GNB2L1	P63244¹	EBI-958408, EBI-296739

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0007166	cell surface receptor linked signal transduction	TAS	8798579
GO:0007259	JAK-STAT cascade	TAS	7588638
GO:0008283	cell proliferation	IEA	--
GO:0009615	response to virus	TAS	7588638

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFNAR2
4 Novoseek chemical compound relationships for IFNAR2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ifn-alpha	82.42	13	15287917 (5), 10777558 (1), 8628273 (1), 15287740 (1) (see all 7)
tyrosine	48.68	15	7526154 (2), 9737924 (1), 8628273 (1), 9374471 (1) (see all 13)
lipid	0.00	1	15312780 (1)
phosphatidylinositol	0.00	1	9162009 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFNAR2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IFNAR2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000874

Sigma-Aldrich siRNA and siRNA Panels for IFNAR2

Sigma-Aldrich shRNA Panels and shRNA for IFNAR2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000874 NM_207584 NM_207585

REFSEQ mRNAs for IFNAR2 gene (3 alternative transcripts):

NM_000874.3 NM_207584.1 NM_207585.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000874 NM_207584 NM_207585

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000874
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000874
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000874

Additional cDNA sequence:

AK293059.1 BC002793.2 BC013156.1 CR541817.1 CR593774.1 CR596140.1 CR603546.1 CR611634.1

L41942.1 L41943.1 L41944.1 U29584.1 X77722.1 X89772.1 X89814.1

10 DOTS entries:

DT.92467568 DT.92467560 DT.86852545 DT.95107171 DT.100025296 DT.100782879 DT.100782885 DT.95148855

DT.121132950 DT.97790884

24/186 AceView cDNA sequences (see all 186 ):

AA316831 CR596140 AA356119 CA309324 BQ709397 AA351430 AI675225 AI005041

BQ022518 BE254594 CR599727 AA962667 NM_207585 CA305937 NM_000874 AA029587

NM_207584 AA234570 CR611634 CR541817 BX093020 CR593774 BI253289 AA760805

highest scoring ESTs for IFNAR2:

AA029587 AA249560 AA316831 AA351430 AA351431 AA865870 AA936250 AA973866 AI005041 AI350535

Unigene Cluster for IFNAR2:

Interferon (alpha, beta and omega) receptor 2

Hs.708195 [show with all ESTs]

Unigene Representative Sequence: L41944

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR2 (see all 9 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14a	·	14b	·	14c
SP1:																			-		-																-				-		-
SP2:							-												-		-										-						-
SP3:																			-		-										-						-
SP4:																			-		-										-						-				-		-
SP5:																			-		-										-						-		-		-		-

About this scheme

ECgene alternative splicing isoforms for IFNAR2

7 Ensembl transcripts including schematic representations:

ENST00000382238 ENST00000318433 ENST00000404220 ENST00000382264 ENST00000342101 ENST00000342136

ENST00000382241

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFNAR2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFNAR2

¹ / ² / ³

7 probe-sets matching IFNAR2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1589_s_at²^{, 3}	U95-A	1	1.00	1.00	0.75	1.23	L42243	0.20	0.50	0.38	1
1588_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.76	L42243	0.20	0.50	0.38	1
1568_s_at²^{, 3}	U95-A	1	1.00	1.00	0.86	1.04	L42243	0.20	0.50	0.38	1
204786_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L41944	0.60	1.00	0.82	1
204785_x_at²^{, 3}	U133-A	3	1.00	0.91	--	--	NM_000874	0.60	0.83	0.73	1
204786_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204785_x_at²	U133Plus2	3	1.00	0.91	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCGTCGGGGA

SOURCE GeneReport for Unigene cluster: Hs.708195
Expression variation in blood from EXPOLDB for IFNAR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IFNAR2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IFNAR2¹	--	interferon (alpha, beta and omega) receptor 2	73.65(n) 59.69(a)	487737 XM_544861.2 XP_544861.2
chimpanzee (Pan troglodytes)	IFNAR2¹	--	interferon (alpha, beta and omega) receptor 2	99.48(n) 99.03(a)	473965 XM_531432.2 XP_531432.2
cow (Bos taurus)	IFNAR2¹	--	interferon (alpha, beta and omega) receptor 2	73.23(n) 59.25(a)	282258 NM_174553.2 NP_776978.1
mouse (Mus musculus)	Ifnar2^{1, 5}	16 (63.10 cM)⁵	interferon (alpha and beta) receptor 2^{1, 5}	65.09(n)¹ 50.21(a)¹	15976¹ NM_010509.1¹ NP_034639.1¹ AF013274⁵ AF013486⁵ (see all 34)
chicken (Gallus gallus)	IFNAR2¹	--	interferon (alpha, beta and omega) receptor 2	43.92(n) 28.14(a)	395664 NM_204858.1 NP_990189.1

About this table Species with no ortholog for IFNAR2

ENSEMBL Gene Tree for IFNAR2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/343 NCBI SNPs in IFNAR2 are shown (see all 343 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 80)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9984273^1,2	C,F,H	33556935(+)	`TGATAT/CGGACT`	3	--	ng3¹ int¹ ese³		14		EU EA WA NA	1440
--	rs17860264^1,2	C,F	33558069(+)	`CTGTCG/ACCCAA`	1	--	ut3¹ ese³		4		NS MN	632
--	rs9975738^1,2	C,F	33524116(+)	`CCGTAG/TCGCTC`	3	--	ut5¹		2		NS	80
--	rs4817552^1,2	A,C	33522439(+)	`tttggG/Tatttt`	3	--	ng5¹ tfbs³		0	--	--	--	--
--	rs9754221^1,2	C,H	33539154(+)	`TTCAAG/CATATC`	3	N/K	mis¹ ese³		9		EU EA WA MN CSAM	804
--	rs1051393^1,2	C,F	33536125(+)	`YCATCT/GTCAGA`	3	V/F	mis¹		27		NA EA MN CSAM EU WA NS	2564
	rs1803787^1,2	C,H	33558381(+)	`AGCAGG/AGAAAG`	1	--	ut3¹ ese³ trp³		9		MN CSAM EA EU WA	810
--	rs3216172^1,2	C,F	33556924(+)	`ACAGT-/TACAGC`	3	--	int¹ ut3¹		2		NS	80
--	rs8178430^1,2	C,F	33557803(+)	`GTTCCT/GTTCTT`	1	--	ut3¹ trp³		11		NS MN	1346
--	rs17860116^1,2	F	33524191(+)	`CCCGCC/TGGCGA`	3	--	ut5¹ ese³		2		NS	80

About this table

HapMap Linkage Disequilibrium images for IFNAR2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602376 disorders: 610424

UniProtKB/Swiss-Prot: INAR2_HUMAN, P48551

Defects in IFNAR2 are associated with susceptibility to hepatitis B virus infection (HBV

infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases

of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result

in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis

requiring liver transplantation

10/18 Novoseek disease relationships for IFNAR2 gene (see all 18 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis c chronic	50.35	11	14996348 (3), 12141824 (2), 12518169 (1), 11170061 (1) (see all 7)
measles	39.78	2	10627547 (1), 18715339 (1)
hepatitis c	37.34	8	12518169 (1), 11170061 (1), 9563926 (1), 15991303 (1) (see all 7)
multiple sclerosis	37.26	2	15885318 (2)
hepatocellular carcinoma	36.20	6	19401692 (1), 16953837 (1), 10853022 (1), 17572015 (1) (see all 6)
virus infection	34.98	3	9563926 (1), 12141824 (1)
carcinoma renal cell	21.35	3	10203606 (1), 10853333 (1), 17572016 (1)
chronic liver disease	19.35	4	15991303 (1), 18583243 (1)
response acute phase	10.36	1	9162009 (1)
breast cancer	5.41	1	1827277 (1)

About this table

Human Gene Mutation Database: IFNAR2
Genetic Association Database: IFNAR2
Human Genome Epidemiology Navigator: IFNAR2 (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/201 PubMed articles for IFNAR2 gene (see all 201 ):

The human interferon alpha/beta receptor: characterization and molecular cloning. (PubMed id 8181059)^{2, 3, 4} Novick D.... Rubinstein M. (1994)
IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. (PubMed id 15885318)^{1, 3, 6} Leyva L....Matesanz F. (2005)
The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. (PubMed id 12842042)^{1, 3, 4} Chill J.H.... Anglister J. (2003)
Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. (PubMed id 12618863)^{1, 3, 6} Sriram U....Oksenberg J.R. (2003)
Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. (PubMed id 7588638)^{1, 3, 4} Lutfalla G.... Uze G. (1995)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{3, 6} Saito T....Kawata S. (2004)
Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. (PubMed id 7665574)^{3, 4} Domanski P....Colamonici O.R. (1995)
Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor. (PubMed id 7759950)^{3, 4} Novick D.... Rubinstein M. (1995)
The combination of IFN-alpha2 and IFN-alpha8 exhibits synergistic antiproliferative activity on renal cell carcinoma (RCC) cell lines through increased binding affinity for IFNAR-2. (PubMed id 17572016)^{1, 3} Tanimoto T....Fukuda S. (2007)
Expression and regulation of IFNalpha/beta receptor in IFNbeta-treated patients with multiple sclerosis. (PubMed id 18971450)^{1, 3} Gilli F....Bertolotto A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3455	HGNC: 5433	AceView: IFNAR2	Ensembl:ENSG00000159110	euGenes: HUgn3455
ECgene: IFNAR2	H-InvDB: IFNAR2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IFNAR2	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/ifnar2/

Licensable Technologies for IFNAR2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for IFNAR2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFNAR2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IFNAR2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IFNAR2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IFNAR2)
	Antibodies (IFNAR2)
	Chimera RNAi (IFNAR2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (IFN alpha/beta Receptor beta, IFNAR2)
	Antibodies (IFN alpha/beta Receptor beta, IFNAR2)

Search OriGene for IFNAR2

Search Tocris compounds for IFNAR2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IFNAR2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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IFNAR2 Gene at Home site.
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IFNAR2 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for IFNAR2

Summaries
for IFNAR2

Genomic Location
for IFNAR2

Proteins
for IFNAR2

Protein Domains/
Families
for IFNAR2

Gene Function
for IFNAR2

Pathways & Interactions
for IFNAR2

Drugs & Compounds
for IFNAR2

Transcripts
for IFNAR2

Expression
for IFNAR2

Orthologs
for IFNAR2

Paralogs
for IFNAR2

SNPs/Variants
for IFNAR2

Disorders & Mutations
for IFNAR2

Medical News
for IFNAR2

Publications
for IFNAR2

Search for IFNAR2

Genome Databases showing IFNAR2

Other Databases showing IFNAR2

Specialized Databases showing IFNAR2

Licensable Technologies
for IFNAR2

Services
for IFNAR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFNAR2 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor IFNAR2

Summariesfor IFNAR2

Genomic Locationfor IFNAR2

Proteinsfor IFNAR2

Protein Domains/Familiesfor IFNAR2

Gene Functionfor IFNAR2

Pathways & Interactionsfor IFNAR2

Drugs & Compoundsfor IFNAR2

Transcriptsfor IFNAR2

Expression for IFNAR2

Orthologsfor IFNAR2

Paralogsfor IFNAR2

SNPs/Variantsfor IFNAR2

Disorders & Mutationsfor IFNAR2

Medical Newsfor IFNAR2

Publicationsfor IFNAR2

Search for IFNAR2

Genome Databases showing IFNAR2

Other Databases showing IFNAR2

Specialized Databases showing IFNAR2

Licensable Technologiesfor IFNAR2

Servicesfor IFNAR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFNAR2

Summaries
for IFNAR2

Genomic Location
for IFNAR2

Proteins
for IFNAR2

Protein Domains/
Families
for IFNAR2

Gene Function
for IFNAR2

Pathways & Interactions
for IFNAR2

Drugs & Compounds
for IFNAR2

Transcripts
for IFNAR2

Expression
for IFNAR2

Orthologs
for IFNAR2

Paralogs
for IFNAR2

SNPs/Variants
for IFNAR2

Disorders & Mutations
for IFNAR2

Medical News
for IFNAR2

Publications
for IFNAR2

Licensable Technologies
for IFNAR2

Services
for IFNAR2