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IFNAR1 Gene

protein-coding   GIFtS: 69
GCID: GC21P034696

Interferon (Alpha, Beta And Omega) Receptor 1


(Previous symbol: IFNAR)
  See IFNAR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Interferon (Alpha, Beta And Omega) Receptor 11 2     AVP2
IFNAR1 2 3     IFN-alpha-REC2
Cytokine Receptor Class-II Member 12 3     IFNBR2
Cytokine Receptor Family 2 Member 12 3     IFRC2
Type I Interferon Receptor 12 3     Alpha-Type Antiviral Protein2
CRF2-12 3     Beta-Type Antiviral Protein2
IFN-R-12 3     Interferon Alpha/Beta Receptor 12
IFN-Alpha/Beta Receptor 12 3     Interferon-Alpha/Beta Receptor Alpha Chain2
Human Interferon-Alpha Receptor (HuIFN-Alpha-Rec)11     Interferon-Beta Receptor 12

External Ids:    HGNC: 54321   Entrez Gene: 34542   Ensembl: ENSG000001421667   OMIM: 1074505   UniProtKB: P171813   

Export aliases for IFNAR1 gene to outside databases

Previous GC identifers: GC21P031274 GC21P033617 GC21P033619 GC21P020166


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFNAR1 Gene:
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for
interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in
turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an
antiviral factor. (provided by RefSeq, Jul 2008)

GeneCards Summary for IFNAR1 Gene:
IFNAR1 (interferon (alpha, beta and omega) receptor 1) is a protein-coding gene. Diseases associated with IFNAR1 include cerebral amyloid angiopathy, and malaria. GO annotations related to this gene include type I interferon receptor activity. An important paralog of this gene is ENSG00000249624.

UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181
Function: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta.
Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT
proteins and IFNR alpha- and beta-subunits themselves

summary for IFNAR1 Gene:
Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis
and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to
oxytocin receptors (OT). V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle
cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found
to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in
the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively
on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.

Gene Wiki entry for IFNAR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFNAR1 gene promoter:
         LHX3b/Lhx3b   STAT1   AML1a   LHX3a/Lhx3a   STAT3   IRF-7A   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNAR1 promoter sequence

   Search Chromatin IP Primers for IFNAR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
IFNAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNAR1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P034696:   GeneLoc Nature:405,311-319
Start:
34,696,734 bp from pter       20,273,930 bp from centromere
End:
34,732,168 bp from pter 20,305,504 bp from centromere
Size:
35,435 bases 31,575 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: X60459
genomic clones: pD71A4 PQ38G8


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181 (See protein sequence)
Recommended Name: Interferon alpha/beta receptor 1 precursor  
Size: 557 amino acids; 63525 Da
Subunit: Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type
I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466.
Interacts with IFNAR2
Sequence caution: Sequence=AAH02590.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
3 PDB 3D structures from and Proteopedia for IFNAR1:
3S98 (3D)        3SE3 (3D)        3SE4 (3D)    
Secondary accessions: B2R6L9 D3DSF0 Q53GW9 Q53H11 Q6PKD7 Q7M4L2 Q8WTZ2
Alternative splicing: 3 isoforms:  P17181-1   P17181-2   P17181-3   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for IFNAR1: NX_P17181

Explore proteomics data for IFNAR1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by TYK2 tyrosine kinase1
  • Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT21
  • Glycosylation2 at Asn50, Asn58, Asn81, Asn88, Asn110, Asn172, Asn254, Asn313, Asn314, Asn376,
                                 Asn416, Asn433
  • Modification sites at PhosphoSitePlus

  • See IFNAR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000620.2  
    ENSEMBL proteins: 
     ENSP00000270139   ENSP00000400161   ENSP00000407406   ENSP00000395606  
    Reactome Protein details: P17181

    IFNAR1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for IFNAR1
    OriGene Custom MassSpec
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    Novus Biologicals IFNAR1 Protein
    Novus Biologicals IFNAR1 Lysates
    Sino Biological Recombinant Protein for IFNAR1
    Sino Biological Cell Lysate for IFNAR1
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IFNAR1 

    IFNAR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search eBioscience for ELISAs for IFNAR1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFN: Interferons

    IUPHAR Guide to PHARMACOLOGY protein family classification: interferon alpha/beta receptor 1
    Interferon receptor family

    4 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR015373 Interferon_alpha/beta_rcpt_bsu
     IPR013783 Ig-like_fold
     IPR016669 Interferon_alpha/beta_rcpt-1

    Graphical View of Domain Structure for InterPro Entry P17181

    ProtoNet protein and cluster: P17181

    UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181
    Similarity: Belongs to the type II cytokine receptor family
    Similarity: Contains 4 fibronectin type-III domains


    Find genes that share domains with IFNAR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INAR1_HUMAN, P17181
    Function: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta.
    Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT
    proteins and IFNR alpha- and beta-subunits themselves

         Genatlas biochemistry entry for IFNAR1:
    interferon alpha/beta (type I),receptor (110kDa),alpha subunit conferring high affinity to the receptor,identified
    by monoclonal antibody IFNaR3,cytokine receptor family II member

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004904interferon receptor activity ----
    GO:0004905type I interferon receptor activity TAS7665574
    GO:0005515protein binding IPI12220192
         
    Find genes that share ontologies with IFNAR1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for IFNAR1:
     Decreased Salmonella enterica   Increased G1 DNA content  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Ifnar1) (see all 16):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     no phenotypic analysis  renal/urinary system  reproductive system  skeleton  tumorigenesis 

    Find genes that share phenotypes with IFNAR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IFNAR1: Ifnar1tm1Pjh Ifnar1tm1Agt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFNAR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFNAR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNAR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNAR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFNAR1:
    hsa-mir-98-5p (MIRT027659)

    Block miRNA regulation of human, mouse, rat IFNAR1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate IFNAR1:
    hsa-miR-141 hsa-miR-200a hsa-miR-4276 hsa-miR-3155 hsa-miR-3155b hsa-miR-570 hsa-miR-484
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IFNAR1
    Predesigned siRNA for gene silencing in human, mouse, rat IFNAR1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IFNAR1

    Clone
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    OriGene clones in human, mouse for IFNAR1 (see all 7)
    OriGene ORF clones in mouse, rat for IFNAR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNAR1 (NM_000629)
    Sino Biological Human cDNA Clone for IFNAR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNAR1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNAR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INAR1_HUMAN, P17181: Isoform 1: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2
    cytosol1
    endoplasmic reticulum1
    endosome1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8181059

    Find genes that share ontologies with IFNAR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFNAR1 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    2Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    Regulation of IFNA signaling0.69
    3Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    4Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    5TGF-Beta Pathway
    JAK-STAT Pathway0.57


    Find genes that share SuperPaths with IFNAR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IFNAR1
        THC Differentiation Pathway
    Interferon Pathway
    JAK-STAT Pathway

    1 GeneGo (Thomson Reuters) Pathway for IFNAR1
        Immune response IFN alpha/beta signaling pathway

    5 BioSystems Pathways for IFNAR1
        Interferon type I
    Toll-like receptor signaling pathway
    Downstream signaling in naive CD8+ T cells
    Osteoclast Signaling
    Regulation of toll-like receptor signaling pathway


    2 Reactome Pathways for IFNAR1
        Regulation of IFNA signaling
    Interferon alpha/beta signaling


    Selected Kegg Pathways  (Kegg details for IFNAR1) (see all 11):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNAR1 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IFNAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IFNAR1 (P171811, 2, 3 ENSP000002701394) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT2P526301, 2, 3, ENSP000003157684EBI-1547250,EBI-1546963 MINT-8029458 MINT-8029443 MINT-8029473 MINT-8029488 MINT-8029503 I2D: score=5 STRING: ENSP00000315768
    TYK2P295972, 3, ENSP000002648184MINT-73134 I2D: score=6 STRING: ENSP00000264818
    IFNA13P015623, ENSP000003944944I2D: score=1 STRING: ENSP00000394494
    FBXW11Q9UKB11, 3, ENSP000002650944EBI-1547250,EBI-355189 I2D: score=4 STRING: ENSP00000265094
    IFNA1P015623, ENSP000002769274I2D: score=1 STRING: ENSP00000276927
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS7665574
    GO:0007259JAK-STAT cascade TAS7665574
    GO:0009615response to virus TAS2153461
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032729positive regulation of interferon-gamma production IEA--

    Find genes that share ontologies with IFNAR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for IFNAR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    d[Leu4,Lys8]-VP Selective V1B agonist[42061-33-6]
    [Arg8]-VasopressinAntidiuretic hormone[113-79-1]
    SR 49059 Selective, orally active vasopressin V1A receptor antagonist [150375-75-0]
    DesmopressinSynthetic vasopressin analog; V1B and V2 agonist[16679-58-6]
    (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin Selective vasopressin V1A antagonist[73168-24-8]

    9 DrugBank Compounds for IFNAR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Peginterferon alfa-2b-- 99210-65-8targetagonist19955815 17139284 15898717 11752352 16953837 17016423
    Interferon alfa-n1Interferon alpha-2 (see all 3)74899-72-2targetagonist10822464 19955815 17139284 11752352 17016423
    Interferon alfa-n3-- --targetagonist19955815 17139284 15898717 11752352 17016423
    Interferon Alfa-2b, RecombinantInterferon alfa-2b (see all 2)99210-65-8targetbinder10567921 17139284 11752352 17016423
    Interferon alfacon-1CIFN (see all 9)118390-30-0targetbinder11752352 12528473 17016423 17139284
    Interferon beta-1aFibroblast interferon (see all 3)145258-61-3targetagonist11747625 10049744 16912135 12034032
    Peginterferon alfa-2a-- 198153-51-4targetagonist19955815 15898717 11752352 16953837
    Interferon Alfa-2a, RecombinantInterferon alfa-2a (see all 3)77907-69-8target--18230610 15898717
    Interferon beta-1bFibroblast interferon (see all 3)145155-23-3targetagonist11752352 10049744

    9 Novoseek inferred chemical compound relationships for IFNAR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ifn-alpha 82.1 25 14532120 (3), 15287917 (2), 17873516 (2), 17627610 (2) (see all 14)
    poly(i-c) 49.1 1 19728309 (1)
    vero toxin 46.5 1 11133022 (1)
    tyrosine 42.4 25 7813427 (5), 8626489 (3), 7479825 (3), 8969169 (2) (see all 13)
    glycosphingolipid 27.6 4 10841076 (2)
    alanine 13.9 1 16171819 (1)
    5fluorouracil 13.7 1 17088986 (1)
    ribavirin 2.92 2 17823081 (2)
    serine 2.87 5 19948722 (1), 9029147 (1), 9677371 (1), 8626489 (1) (see all 5)



    Find genes that share compounds with IFNAR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFNAR1 gene: 
    NM_000629.2  

    Unigene Cluster for IFNAR1:

    Interferon (alpha, beta and omega) receptor 1
    Hs.529400  [show with all ESTs]
    Unigene Representative Sequence: NM_000629
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493503 ENST00000270139(uc011adv.2 uc002yrn.3) ENST00000442071
    ENST00000442357 ENST00000416947
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate IFNAR1:
    hsa-miR-141 hsa-miR-200a hsa-miR-4276 hsa-miR-3155 hsa-miR-3155b hsa-miR-570 hsa-miR-484
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Primer
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    OriGene qPCR primer pairs and template standards for IFNAR1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFNAR1
      QuantiTect SYBR Green Assays in human, mouse, rat IFNAR1
      QuantiFast Probe-based Assays in human, mouse, rat IFNAR1

    Additional mRNA sequence: 

    AK123813.1 AK222770.1 AK222812.1 AK298051.1 AK312631.1 BC002590.2 BC014338.1 BC021825.1 
    BC035603.1 BC065751.1 BX537636.1 DQ655972.2 DQ655973.3 J03171.1 

    12 DOTS entries:

    DT.95163268  DT.444906  DT.91779365  DT.100768129  DT.100768130  DT.100768134  DT.121131772  DT.121131784 
    DT.121131798  DT.97838815  DT.70100568  DT.95163267 

    Selected AceView cDNA sequences (see all 241):

    AU106602 BX093717 AA365604 BG819073 AI083512 AA907293 AW134910 AA447872 
    AI825009 BG548299 BM980005 BQ576101 AI371827 Z39123 AA970071 BM676225 
    CR607541 AI867224 BM903878 AA917830 AI627581 H99298 BM784811 BM452951 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
    SP1:                                                                                                
    SP2:        -                                                                                       
    SP3:                                                                                      -         


    ECgene alternative splicing isoforms for IFNAR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFNAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGAGCTC
    IFNAR1 Expression
    About this image


    IFNAR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    IFNAR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFNAR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529400

    UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181
    Tissue specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells.
    Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2
    and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in
    IFN-alpha resistant myeloma cell line U266R

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNAR1 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IFNAR1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifnar11 , 5 interferon (alpha and beta) receptor 11, 5 66.05(n)1
    50.83(a)1
      16 (52.98 cM)5
    159751  NM_010508.21  NP_034638.21 
     914852385 
    chicken
    (Gallus gallus)
    Aves IFNAR11 interferon (alpha, beta and omega) receptor 1 54.39(n)
    39.25(a)
      395665  NM_204859.1  NP_990190.1 
    lizard
    (Anolis carolinensis)
    Reptilia IFNAR16
    interferon (alpha, beta and omega) receptor 1
    34(a)
    1 ↔ 1
    GL343628.1(308973-325361)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004985521 interferon alpha/beta receptor 1-like 46.45(n)
    30.33(a)
      100498552  XM_002942796.2  XP_002942842.2 
    zebrafish
    (Danio rerio)
    Actinopterygii crfb51 cytokine receptor family member b5 42.18(n)
    33.33(a)
      619391  NM_001034185.2  NP_001029357.2 


    ENSEMBL Gene Tree for IFNAR1 (if available)
    TreeFam Gene Tree for IFNAR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFNAR1 gene
    ENSG000002496242  IL10RB2  

    Find genes that share paralogs with IFNAR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IFNAR1 (see all 937)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3744283011,2
    C--34695238(+) ATATAC/TTGGAA 1 -- us2k10--------
    rs1925591841,2
    --34695378(+) ATATAC/TATGGA 1 -- us2k10--------
    rs1845369061,2
    --34695391(+) ATATAG/TATATG 1 -- us2k10--------
    rs1885883451,2
    --34695393(+) ATATAG/TATGGC 1 -- us2k10--------
    rs1813827681,2
    --34695398(+) TATGGA/CATATA 1 -- us2k10--------
    rs1842288571,2
    --34695406(+) ATATAC/TATGGA 1 -- us2k10--------
    rs1889544441,2
    --34695419(+) ATATAG/TATATG 1 -- us2k10--------
    rs1817252181,2
    --34695421(+) ATATAG/TATGGC 1 -- us2k10--------
    rs1872135891,2
    --34695518(+) ATATAG/TATATG 1 -- us2k10--------
    rs1920885861,2
    --34695520(+) ATATAG/TATGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFNAR1 (34696734 - 34732168 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IFNAR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268656CNV Insertion20981092
    dgv4738n71CNV Loss21882294
    nsv834087CNV Gain17160897

    Human Gene Mutation Database (HGMD): IFNAR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNAR1
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNAR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107450    OMIM disorders: --

    2 diseases for IFNAR1:    
    About MalaCards
    cerebral amyloid angiopathy    malaria


    Find genes that share disorders with IFNAR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IFNAR1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 48.5 7 19103527 (1), 18761606 (1), 19154989 (1), 9563926 (1) (see all 6)
    multiple sclerosis 47.5 5 15885318 (2), 18482773 (2)
    hepatitis c chronic 45.6 5 15107924 (2), 17823081 (1), 12141824 (1)
    cerebral amyloid angiopathy 43.8 5 2309274 (2), 7810298 (1), 2408196 (1)
    down syndrome 30.5 2 15487707 (2)
    hepatitis c 30.4 2 15990456 (1), 9563926 (1)
    lupus erythematosus systemic 10.3 1 18393399 (1)
    myeloma 8.51 5 8307198 (1), 7813427 (1), 14647450 (1)
    carcinoma renal cell 7.63 1 17697365 (1)
    brain diseases 7.44 2 2408196 (1)

    Genetic Association Database (GAD): IFNAR1
    Human Genome Epidemiology (HuGE) Navigator: IFNAR1 (38 documents)

    Export disorders for IFNAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFNAR1 gene, integrated from 10 sources (see all 272):
    (articles sorted by number of sources associating them with IFNAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection. (PubMed id 18761606)1, 4, 9 Zhou J....Zheng B.J. (J. Viral Hepat. 2009)
    2. Exhaustive genotyping of the interferon alpha receptor 1 (IFNAR1) gene and association of an IFNAR1 protein variant with AIDS progression or susceptibility to HIV-1 infection in a French AIDS cohort. (PubMed id 17027223)1, 4, 9 Diop G....Zagury J.F. (amp 2006)
    3. Association of two variants of the interferon-alpha receptor-1 gene with the presentation of hepatitis B virus infection. (PubMed id 19103527)1, 4, 9 Song l.e. .H....Kun J.F. (Eur. Cytokine Netw. 2008)
    4. Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. (PubMed id 12761564)1, 4, 9 Aucan C....Hill A.V. (Genes Immun. 2003)
    5. Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN- alpha. (PubMed id 19561067)1, 2, 9 Claudinon J.... Lamaze C. (J. Biol. Chem. 2009)
    6. IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. (PubMed id 15885318)1, 4, 9 Leyva L....Matesanz F. (J. Neuroimmunol. 2005)
    7. Polymorphisms in the IFNAR1 gene in patients with chronic hepatitis C: outcome of combined IFN-alpha therapy. (PubMed id 17823081)1, 4, 9 Tena-TomA!s C....Kun J.F. (Eur. Cytokine Netw. 2007)
    8. Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. (PubMed id 12618863)1, 4, 9 Sriram U....Oksenberg J.R. (Genes Immun. 2003)
    9. The structure of the human interferon alpha/beta receptor gene. (PubMed id 1370833)1, 2, 9 Lutfalla G.... Uze G. (J. Biol. Chem. 1992)
    10. Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection. (PubMed id 17125879)1, 4, 9 Zhou J....Zheng B.J. (J. Hepatol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3454 HGNC: 5432 AceView: IFNAR1 Ensembl:ENSG00000142166 euGenes: HUgn3454
    ECgene: IFNAR1 Kegg: 3454 H-InvDB: IFNAR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFNAR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IFNAR1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ifnar1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFNAR1 gene:
    Search GeneIP for patents involving IFNAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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