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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNAR1 Gene

protein-coding   GIFtS: 67
GCID: GC21P034696

Interferon (Alpha, Beta And Omega) Receptor 1


(Previous symbol: IFNAR)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Interferon (Alpha, Beta And Omega) Receptor 11 2     AVP2
IFNAR1 2 3     IFN-alpha-REC2
Cytokine Receptor Class-II Member 12 3     IFNBR2
Cytokine Receptor Family 2 Member 12 3     IFRC2
Type I Interferon Receptor 12 3     Alpha-Type Antiviral Protein2
CRF2-12 3     Beta-Type Antiviral Protein2
IFN-R-12 3     Interferon Alpha/Beta Receptor 12
IFN-Alpha/Beta Receptor 12 3     Interferon-Alpha/Beta Receptor Alpha Chain2
Human Interferon-Alpha Receptor (HuIFN-Alpha-Rec)11     Interferon-Beta Receptor 12

External Ids:    HGNC: 54321   Entrez Gene: 34542   Ensembl: ENSG000001421667   OMIM: 1074505   UniProtKB: P171813   

Export aliases for IFNAR1 gene to outside databases

Previous GC identifers: GC21P031274 GC21P033617 GC21P033619 GC21P020166


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNAR1 Gene:
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for
interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in
turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an
antiviral factor. (provided by RefSeq, Jul 2008)

GeneCards Summary for IFNAR1 Gene: 
IFNAR1 (interferon (alpha, beta and omega) receptor 1) is a protein-coding gene. Diseases associated with IFNAR1 include rift valley fever, and hepatitis b virus infection, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include type I interferon receptor activity. An important paralog of this gene is ENSG00000249624.

UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181
Function: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta.
Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT
proteins and IFNR alpha- and beta-subunits themselves

summary for IFNAR1 Gene:
Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis
and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to
oxytocin receptors (OT). V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle
cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found
to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in
the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively
on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.

Gene Wiki entry for IFNAR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFNAR1 gene promoter:
         LHX3b/Lhx3b   STAT1   AML1a   LHX3a/Lhx3a   STAT3   IRF-7A   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNAR1 promoter sequence

   Search SABiosciences Chromatin IP Primers for IFNAR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
IFNAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNAR1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P034696:   GeneLoc Nature:405,311-319
Start:
34,696,734 bp from pter       20,273,930 bp from centromere
End:
34,732,168 bp from pter 20,305,504 bp from centromere
Size:
35,435 bases 31,575 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: X60459
genomic clones: pD71A4 PQ38G8


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181 (See protein sequence)
Recommended Name: Interferon alpha/beta receptor 1 precursor  
Size: 557 amino acids; 63525 Da
Subunit: Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type
I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466.
Interacts with IFNAR2
Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAH02590.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
3 PDB 3D structures from and Proteopedia for IFNAR1:
3S98 (3D)        3SE3 (3D)        3SE4 (3D)    
Secondary accessions: B2R6L9 D3DSF0 Q53GW9 Q53H11 Q6PKD7 Q7M4L2 Q8WTZ2
Alternative splicing: 3 isoforms:  P17181-1   P17181-2   P17181-3   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for IFNAR1: NX_P17181

Explore proteomics data for IFNAR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues by TYK2 tyrosine kinase
  • UniProtKB: Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17181

  • IFNAR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFNAR1 Protein Expression
    REFSEQ proteins: NP_000620.2  
    ENSEMBL proteins: 
     ENSP00000270139   ENSP00000400161   ENSP00000407406   ENSP00000395606  
    Reactome Protein details: P17181
    Human Recombinant Protein Products for IFNAR1: 
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    R&D Systems Recombinant & Natural Proteins for IFNAR1 (IFN-alpha/beta R1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IFNAR1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IFNAR1
    GenScript Custom Purified and Recombinant Proteins Services for IFNAR1
    Novus Biologicals IFNAR1 Protein
    Novus Biologicals IFNAR1 Lysates
    Sino Biological Recombinant Protein for IFNAR1
    Sino Biological Cell Lysate for IFNAR1 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8181059

    IFNAR1 for ontologies           About GeneDecksing



    IFNAR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFN: Interferons

    IUPHAR Guide to PHARMACOLOGY protein family classification: interferon α/β receptor 1 
    Interferon receptor family

    4 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR015373 Interferon_alpha/beta_rcpt_bsu
     IPR013783 Ig-like_fold
     IPR016669 Interferon_alpha/beta_rcpt-1

    Graphical View of Domain Structure for InterPro Entry P17181

    ProtoNet protein and cluster: P17181

    UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181
    Similarity: Belongs to the type II cytokine receptor family
    Similarity: Contains 3 fibronectin type-III domains


    IFNAR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INAR1_HUMAN, P17181
    Function: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta.
    Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT
    proteins and IFNR alpha- and beta-subunits themselves

         Genatlas biochemistry entry for IFNAR1:
    interferon alpha/beta (type I),receptor (110kDa),alpha subunit conferring high affinity to the receptor,identified
    by monoclonal antibody IFNaR3,cytokine receptor family II member

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004904interferon receptor activity ----
    GO:0004905type I interferon receptor activity TAS7665574
    GO:0005515protein binding IPI12220192
         
    IFNAR1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for IFNAR1:
     Decreased Salmonella enterica   Increased G1 DNA content  Upregulation of Wnt/beta-caten 

         15/16 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ifnar1) (see all 16):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     no phenotypic analysis  renal/urinary system  reproductive system  skeleton  tumorigenesis 

    IFNAR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IFNAR1: Ifnar1tm1Pjh Ifnar1tm1Agt

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNAR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNAR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNAR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNAR1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNAR1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNAR1:
    hsa-miR-141 hsa-miR-200a hsa-miR-4276 hsa-miR-3155 hsa-miR-3155b hsa-miR-570 hsa-miR-484
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of IFNAR1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IFNAR1 (see all 8)
    OriGene ORF clones in mouse, rat for IFNAR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNAR1 (NM_000629)
    Sino Biological Human cDNA Clone for IFNAR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNAR1
    Sirion Biotech Customized lentivirus for stable overexpression of IFNAR1 
                         Customized lentivirus expression plasmids for stable overexpression of IFNAR1 

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    GenScript Custom overexpressing Cell Line Services for IFNAR1
    Search LifeMap BioReagents cell lines for IFNAR1
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNAR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFNAR1 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    Toll-like receptor signaling pathway0.93
    2Immune response IFN alpha/beta signaling pathway
    Immune response IFN alpha/beta signaling pathway0.71
    Interferon alpha/beta signaling0.45
    Regulation of IFNA signaling0.71
    3Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    4Interferon Signaling
    Interferon Signaling0.61
    Cytokine Signaling in Immune system0.61
    5TGF-Beta Pathway
    JAK-STAT Pathway0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IFNAR1
        Immune response IFN alpha/beta signaling pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNAR1
        THC Differentiation Pathway
    Interferon Pathway
    JAK-STAT Pathway

    1 GeneGo (Thomson Reuters) Pathway for IFNAR1
        Immune response IFN alpha/beta signaling pathway

    3 BioSystems Pathways for IFNAR1
        Toll-like receptor signaling pathway
    Downstream signaling in naive CD8+ T cells
    Osteoclast Signaling


    5        Reactome Pathways for IFNAR1
        Regulation of IFNA signaling
    Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System


    5/11         Kegg Pathways  (Kegg details for IFNAR1) (see all 11):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    Jak-STAT signaling pathway


    IFNAR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFNAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/60 Interacting proteins for IFNAR1 (P171812, 3 ENSP000002701394) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT2P526302, 3, ENSP000003157684MINT-8029458 MINT-8029443 MINT-8029473 MINT-8029488 MINT-8029503 I2D: score=5 STRING: ENSP00000315768
    TYK2P295972, 3, ENSP000002648184MINT-73134 I2D: score=6 STRING: ENSP00000264818
    IFNA13P015623, ENSP000003944944I2D: score=1 STRING: ENSP00000394494
    IFNA1P015623, ENSP000002769274I2D: score=1 STRING: ENSP00000276927
    PIK3R1P279863, ENSP000002743354I2D: score=3 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS7665574
    GO:0007259JAK-STAT cascade TAS7665574
    GO:0009615response to virus TAS2153461
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032729positive regulation of interferon-gamma production IEA--

    IFNAR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IFNAR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for IFNAR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    d[Leu4,Lys8]-VP Selective V1B agonist[42061-33-6]
    [Arg8]-VasopressinAntidiuretic hormone[113-79-1]
    SR 49059 Selective, orally active vasopressin V1A receptor antagonist [150375-75-0]
    DesmopressinSynthetic vasopressin analog; V1B and V2 agonist[16679-58-6]
    (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin Selective vasopressin V1A antagonist[73168-24-8]

    9 DrugBank Compounds for IFNAR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Peginterferon alfa-2b-- 99210-65-8targetagonist19955815 17139284 15898717 11752352 16953837 17016423
    Interferon alfa-n1Interferon alpha-2 (see all 3)74899-72-2targetagonist10822464 19955815 17139284 11752352 17016423
    Interferon alfa-n3-- --targetagonist19955815 17139284 15898717 11752352 17016423
    Interferon Alfa-2b, RecombinantInterferon alfa-2b (see all 2)99210-65-8targetbinder10567921 17139284 11752352 17016423
    Interferon alfacon-1CIFN (see all 9)118390-30-0targetbinder11752352 12528473 17016423 17139284
    Interferon beta-1aFibroblast interferon (see all 3)145258-61-3targetagonist11747625 10049744 16912135 12034032
    Peginterferon alfa-2a-- 198153-51-4targetagonist19955815 15898717 11752352 16953837
    Interferon Alfa-2a, RecombinantInterferon alfa-2a (see all 3)77907-69-8target--18230610 15898717
    Interferon beta-1bFibroblast interferon (see all 3)145155-23-3targetagonist11752352 10049744

    9 Novoseek inferred chemical compound relationships for IFNAR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ifn-alpha 82.1 25 14532120 (3), 15287917 (2), 17873516 (2), 17627610 (2) (see all 14)
    poly(i-c) 49.1 1 19728309 (1)
    vero toxin 46.5 1 11133022 (1)
    tyrosine 42.4 25 7813427 (5), 8626489 (3), 7479825 (3), 8969169 (2) (see all 13)
    glycosphingolipid 27.6 4 10841076 (2)
    alanine 13.9 1 16171819 (1)
    5fluorouracil 13.7 1 17088986 (1)
    ribavirin 2.92 2 17823081 (2)
    serine 2.87 5 19948722 (1), 9029147 (1), 9677371 (1), 8626489 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about IFNAR1 / INAR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFNAR1 gene: 
    NM_000629.2  

    Unigene Cluster for IFNAR1:

    Interferon (alpha, beta and omega) receptor 1
    Hs.529400  [show with all ESTs]
    Unigene Representative Sequence: NM_000629
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493503 ENST00000270139(uc011adv.2 uc002yrn.3) ENST00000442071
    ENST00000442357 ENST00000416947
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    OriGene clones in human, mouse for IFNAR1 (see all 8)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNAR1
    Sirion Biotech Customized lentivirus for stable overexpression of IFNAR1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNAR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNAR1

    Additional mRNA sequence: 

    AK123813.1 AK222770.1 AK222812.1 AK298051.1 AK312631.1 BC002590.2 BC014338.1 BC021825.1 
    BC035603.1 BC065751.1 BX537636.1 DQ655972.2 DQ655973.3 J03171.1 

    12 DOTS entries:

    DT.95163268  DT.444906  DT.91779365  DT.100768129  DT.100768130  DT.100768134  DT.121131772  DT.121131784 
    DT.121131798  DT.97838815  DT.70100568  DT.95163267 

    24/241 AceView cDNA sequences (see all 241):

    AI867224 AA907293 BQ026873 AI371827 BQ006427 BM784811 BC021825 AA447872 
    H55894 AI217189 AI141535 AU106601 CA309474 H61868 AA365593 AI168179 
    AI338136 AI824699 AI825009 CD671584 BM713024 AU106600 AA813473 AA418297 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
    SP1:                                                                                                
    SP2:        -                                                                                       
    SP3:                                                                                      -         


    ECgene alternative splicing isoforms for IFNAR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFNAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGAGCTC
    IFNAR1 Expression
    About this image


    See IFNAR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFNAR1

    SOURCE GeneReport for Unigene cluster: Hs.529400

    UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181
    Tissue specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells.
    Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2
    and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in
    IFN-alpha resistant myeloma cell line U266R

        SABiosciences Expression via Pathway-Focused PCR Arrays including IFNAR1 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IFNAR1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ifnar11 , 5 interferon (alpha and beta) receptor 11, 5 66.11(n)1
    50.65(a)1
      16 (52.98 cM)5
    159751  NM_010508.21  NP_034638.21 
     914852385 
    chicken
    (Gallus gallus)
    Aves IFNAR11 interferon (alpha, beta and omega) receptor 1 54.27(n)
    39.07(a)
      395665  NM_204859.1  NP_990190.1 
    lizard
    (Anolis carolinensis)
    Reptilia IFNAR16
    Uncharacterized protein
    32(a)
    1 ↔ 1
    GL343628.1(308973-325361)
    zebrafish
    (Danio rerio)
    Actinopterygii crfb51 cytokine receptor family member b5 41.37(n)
    32.48(a)
      619391  NM_001034185.2  NP_001029357.2 


    ENSEMBL Gene Tree for IFNAR1 (if available)
    TreeFam Gene Tree for IFNAR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFNAR1 gene
    ENSG000002496242  IFNGR22  IL10RB2  

    IFNAR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/937 SNPs in IFNAR1 are shown (see all 937)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3744283011,2
    C--34695238(+) ATATAC/TTGGAA 1 -- us2k10--------
    rs1925591841,2
    --34695378(+) ATATAC/TATGGA 1 -- us2k10--------
    rs1845369061,2
    --34695391(+) ATATAG/TATATG 1 -- us2k10--------
    rs1885883451,2
    --34695393(+) ATATAG/TATGGC 1 -- us2k10--------
    rs1813827681,2
    --34695398(+) TATGGA/CATATA 1 -- us2k10--------
    rs1842288571,2
    --34695406(+) ATATAC/TATGGA 1 -- us2k10--------
    rs1889544441,2
    --34695419(+) ATATAG/TATATG 1 -- us2k10--------
    rs1817252181,2
    --34695421(+) ATATAG/TATGGC 1 -- us2k10--------
    rs1872135891,2
    --34695518(+) ATATAG/TATATG 1 -- us2k10--------
    rs1920885861,2
    --34695520(+) ATATAG/TATGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFNAR1 (34696734 - 34732168 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IFNAR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv268656CNV Insertion20981092
    dgv4738n71CNV Loss21882294
    nsv834087CNV Gain17160897


    Human Gene Mutation Database (HGMD): IFNAR1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107450    OMIM disorders: --

    20/41 diseases for IFNAR1 (see all 41):    About MalaCards
    rift valley fever    hepatitis b virus infection    cerebral amyloid angiopathy    west nile virus
    cerebral malaria    myelitis    brain disease    cblc
    malaria    dengue hemorrhagic fever    hepatitis c    cervical intraepithelial neoplasia
    hemorrhagic fever    stomatitis    multiple sclerosis    down syndrome
    measles    hepatitis b    cerebritis    chronic myeloid leukemia


    IFNAR1 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for IFNAR1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 48.5 7 19103527 (1), 18761606 (1), 19154989 (1), 9563926 (1) (see all 6)
    multiple sclerosis 47.5 5 15885318 (2), 18482773 (2)
    hepatitis c chronic 45.6 5 15107924 (2), 17823081 (1), 12141824 (1)
    cerebral amyloid angiopathy 43.8 5 2309274 (2), 7810298 (1), 2408196 (1)
    down syndrome 30.5 2 15487707 (2)
    hepatitis c 30.4 2 15990456 (1), 9563926 (1)
    lupus erythematosus systemic 10.3 1 18393399 (1)
    myeloma 8.51 5 8307198 (1), 7813427 (1), 14647450 (1)
    carcinoma renal cell 7.63 1 17697365 (1)
    brain diseases 7.44 2 2408196 (1)

    Genetic Association Database (GAD): IFNAR1
    Human Genome Epidemiology (HuGE) Navigator: IFNAR1 (38 documents)

    Export disorders for IFNAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFNAR1 gene, integrated from 9 sources (see all 270):
    (articles sorted by number of sources associating them with IFNAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection. (PubMed id 18761606)1, 4, 9 Zhou J....Zheng B.J. (2008)
    2. Exhaustive genotyping of the interferon alpha receptor 1 (IFNAR1) gene and association of an IFNAR1 protein variant with AIDS progression or susceptibility to HIV-1 infection in a French AIDS cohort. (PubMed id 17027223)1, 4, 9 Diop G....Zagury J.F. (2006)
    3. Association of two variants of the interferon-alpha receptor-1 gene with the presentation of hepatitis B virus infection. (PubMed id 19103527)1, 4, 9 Song l.e. .H....Kun J.F. (2008)
    4. Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. (PubMed id 12761564)1, 4, 9 Aucan C....Hill A.V. (2003)
    5. Palmitoylation of interferon-alpha (IFN-alpha) recept or subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alph a. (PubMed id 19561067)1, 2, 9 Claudinon J....Lamaze C. (2009)
    6. IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. (PubMed id 15885318)1, 4, 9 Leyva L....Matesanz F. (2005)
    7. Polymorphisms in the IFNAR1 gene in patients with chronic hepatitis C: outcome of combined IFN-alpha therapy. (PubMed id 17823081)1, 4, 9 Tena-Tomas C....Kun J.F. (2007)
    8. Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. (PubMed id 12618863)1, 4, 9 Sriram U....Oksenberg J.R. (2003)
    9. The structure of the human interferon alpha/beta receptor gene. (PubMed id 1370833)1, 2, 9 Lutfalla G.... Uze G. (1992)
    10. Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection. (PubMed id 17125879)1, 4, 9 Zhou J....Zheng B.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3454 HGNC: 5432 AceView: IFNAR1 Ensembl:ENSG00000142166 euGenes: HUgn3454
    ECgene: IFNAR1 Kegg: 3454 H-InvDB: IFNAR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFNAR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IFNAR1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ifnar1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFNAR1 gene:
    Search GeneIP for patents involving IFNAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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