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Aliases for IFNAR1 Gene

Aliases for IFNAR1 Gene

  • Interferon (Alpha, Beta And Omega) Receptor 1 2 3
  • Cytokine Receptor Class-II Member 1 3 4
  • Cytokine Receptor Family 2 Member 1 3 4
  • Type I Interferon Receptor 1 3 4
  • IFN-Alpha/Beta Receptor 1 3 4
  • IFN-R-1 3 4
  • CRF2-1 3 4
  • IFNAR 3 4
  • Interferon-Alpha/Beta Receptor Alpha Chain 3
  • Interferon Alpha/Beta Receptor 1 3
  • Alpha-Type Antiviral Protein 3
  • Beta-Type Antiviral Protein 3
  • Interferon-Beta Receptor 1 3
  • IFN-Alpha-REC 3
  • IFNBR 3
  • IFRC 3
  • AVP 3

External Ids for IFNAR1 Gene

Previous Symbols for IFNAR1 Gene

  • IFNAR

Summaries for IFNAR1 Gene

Entrez Gene Summary for IFNAR1 Gene

  • The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNAR1 Gene

IFNAR1 (Interferon (Alpha, Beta And Omega) Receptor 1) is a Protein Coding gene. Diseases associated with IFNAR1 include cerebral amyloid angiopathy and malaria. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include type I interferon receptor activity. An important paralog of this gene is IL10RB.

UniProtKB/Swiss-Prot for IFNAR1 Gene

  • Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway

Gene Wiki entry for IFNAR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNAR1 Gene

Genomics for IFNAR1 Gene

Genomic Location for IFNAR1 Gene

Start:
33,324,443 bp from pter
End:
33,359,862 bp from pter
Size:
35,420 bases
Orientation:
Plus strand

Genomic View for IFNAR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNAR1 Gene

Regulatory Elements for IFNAR1 Gene

Proteins for IFNAR1 Gene

  • Protein details for IFNAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17181-INAR1_HUMAN
    Recommended name:
    Interferon alpha/beta receptor 1
    Protein Accession:
    P17181
    Secondary Accessions:
    • B2R6L9
    • B4DNT3
    • D3DSF0
    • Q53GW9
    • Q53H11
    • Q6PKD7
    • Q7M4L2
    • Q8WTZ2

    Protein attributes for IFNAR1 Gene

    Size:
    557 amino acids
    Molecular mass:
    63525 Da
    Quaternary structure:
    • Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2.
    SequenceCaution:
    • Sequence=AAH02590.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IFNAR1 Gene

    Alternative splice isoforms for IFNAR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFNAR1 Gene

Proteomics data for IFNAR1 Gene at MOPED

Post-translational modifications for IFNAR1 Gene

  • Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.
  • Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn50, Asn58, Asn81, Asn88, Asn110, Asn172, Asn254, Asn313, Asn314, Asn376, Asn416, and Asn433

Other Protein References for IFNAR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNAR1 Gene

Domains for IFNAR1 Gene

Gene Families for IFNAR1 Gene

Protein Domains for IFNAR1 Gene

Suggested Antigen Peptide Sequences for IFNAR1 Gene

Graphical View of Domain Structure for InterPro Entry

P17181

UniProtKB/Swiss-Prot:

INAR1_HUMAN
Domain:
  • Contains 4 fibronectin type-III domains.:
    • P17181
Family:
  • Belongs to the type II cytokine receptor family.:
    • P17181
genes like me logo Genes that share domains with IFNAR1: view

Function for IFNAR1 Gene

Molecular function for IFNAR1 Gene

GENATLAS Biochemistry: interferon alpha/beta (type I),receptor (110kDa),alpha subunit conferring high affinity to the receptor,identified by monoclonal antibody IFNaR3,cytokine receptor family II member
UniProtKB/Swiss-Prot Function: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway

Gene Ontology (GO) - Molecular Function for IFNAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004904 interferon receptor activity IBA --
GO:0004905 type I interferon receptor activity TAS 7665574
GO:0005515 protein binding IPI 12220192
genes like me logo Genes that share ontologies with IFNAR1: view
genes like me logo Genes that share phenotypes with IFNAR1: view

Animal Models for IFNAR1 Gene

MGI Knock Outs for IFNAR1:

miRNA for IFNAR1 Gene

miRTarBase miRNAs that target IFNAR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IFNAR1 Gene

Localization for IFNAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNAR1 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNAR1 Gene COMPARTMENTS Subcellular localization image for IFNAR1 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 1
endoplasmic reticulum 1
endosome 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFNAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8181059
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with IFNAR1: view

Pathways for IFNAR1 Gene

genes like me logo Genes that share pathways with IFNAR1: view

Gene Ontology (GO) - Biological Process for IFNAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 7665574
GO:0007259 JAK-STAT cascade TAS 7665574
GO:0009615 response to virus TAS 2153461
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032729 positive regulation of interferon-gamma production IEA --
genes like me logo Genes that share ontologies with IFNAR1: view

Compounds for IFNAR1 Gene

(9) Drugbank Compounds for IFNAR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Interferon Alfa-2a, Recombinant
  • Interferon alfa-2a
77907-69-8 target
Interferon Alfa-2b, Recombinant
  • Interferon alfa-2b
99210-65-8 target binder
Interferon alfacon-1
  • CIFN
118390-30-0 target binder
Interferon alfa-n1
  • Interferon alpha-2
74899-72-2 target agonist
Interferon alfa-n3
target agonist

(9) Novoseek inferred chemical compound relationships for IFNAR1 Gene

Compound -log(P) Hits PubMed IDs
ifn-alpha 82.1 19
poly(i-c) 49.1 1
vero toxin 46.5 1
tyrosine 42.4 22
glycosphingolipid 27.6 2
genes like me logo Genes that share compounds with IFNAR1: view

Transcripts for IFNAR1 Gene

Unigene Clusters for IFNAR1 Gene

Interferon (alpha, beta and omega) receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1:
SP2: -
SP3: -

Relevant External Links for IFNAR1 Gene

GeneLoc Exon Structure for
IFNAR1
ECgene alternative splicing isoforms for
IFNAR1

Expression for IFNAR1 Gene

mRNA expression in normal human tissues for IFNAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFNAR1 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IFNAR1 Gene

SOURCE GeneReport for Unigene cluster for IFNAR1 Gene Hs.529400

mRNA Expression by UniProt/SwissProt for IFNAR1 Gene

P17181-INAR1_HUMAN
Tissue specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
genes like me logo Genes that share expressions with IFNAR1: view

Orthologs for IFNAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNAR1 35
  • 99.46 (n)
  • 99.28 (a)
IFNAR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFNAR1 35
  • 80.32 (n)
  • 67.51 (a)
IFNAR1 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
LOC100856529 35
  • 80.07 (n)
  • 70.47 (a)
mouse
(Mus musculus)
Mammalia Ifnar1 35
  • 66.05 (n)
  • 50.83 (a)
Ifnar1 16
Ifnar1 36
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IFNAR1 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFNAR1 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifnar1 35
  • 66.6 (n)
  • 52.35 (a)
chicken
(Gallus gallus)
Aves IFNAR1 35
  • 54.39 (n)
  • 39.25 (a)
IFNAR1 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFNAR1 36
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498552 35
  • 46.45 (n)
  • 30.33 (a)
zebrafish
(Danio rerio)
Actinopterygii crfb5 35
  • 42.18 (n)
  • 33.33 (a)
crfb5 36
  • 19 (a)
OneToOne
Species with no ortholog for IFNAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFNAR1 Gene

ENSEMBL:
Gene Tree for IFNAR1 (if available)
TreeFam:
Gene Tree for IFNAR1 (if available)

Paralogs for IFNAR1 Gene

Paralogs for IFNAR1 Gene

genes like me logo Genes that share paralogs with IFNAR1: view

Variants for IFNAR1 Gene

Sequence variations from dbSNP and Humsavar for IFNAR1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs909141 -- 33,356,522(+) GTTTA(A/G)GATTA utr-variant-3-prime
rs914141 -- 33,353,162(+) GTATT(G/T)CTCTT intron-variant
rs914142 -- 33,353,501(+) GTGCT(A/G)CCAGA intron-variant
rs1012334 -- 33,341,445(+) ttttt(A/T)atttt intron-variant
rs1012335 -- 33,341,701(+) TTTGA(C/G)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFNAR1 Gene

Variant ID Type Subtype PubMed ID
nsv834087 CNV Gain 17160897
esv268656 CNV Insertion 20981092
dgv4738n71 CNV Loss 21882294

Relevant External Links for IFNAR1 Gene

HapMap Linkage Disequilibrium report
IFNAR1
Human Gene Mutation Database (HGMD)
IFNAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNAR1 Gene

Disorders for IFNAR1 Gene

(12) Novoseek inferred disease relationships for IFNAR1 Gene

Disease -log(P) Hits PubMed IDs
virus infection 48.5 6
multiple sclerosis 47.5 4
hepatitis c chronic 45.6 4
cerebral amyloid angiopathy 43.8 4
down syndrome 30.5 2

Relevant External Links for IFNAR1

Genetic Association Database (GAD)
IFNAR1
Human Genome Epidemiology (HuGE) Navigator
IFNAR1
genes like me logo Genes that share disorders with IFNAR1: view

No data available for UniProtKB/Swiss-Prot for IFNAR1 Gene

Publications for IFNAR1 Gene

  1. The structure of the human interferon alpha/beta receptor gene. (PMID: 1370833) Lutfalla G. … Uze G. (J. Biol. Chem. 1992) 3 4 23
  2. IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. (PMID: 15885318) Leyva L. … Matesanz F. (J. Neuroimmunol. 2005) 3 23 48
  3. Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings. (PMID: 15990456) Yoshida K. … Miller A.H. (Neuropsychobiology 2005) 3 23 48
  4. Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. (PMID: 12618863) Sriram U. … Oksenberg J.R. (Genes Immun. 2003) 3 23 48
  5. Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. (PMID: 12761564) Aucan C. … Hill A.V. (Genes Immun. 2003) 3 23 48

Products for IFNAR1 Gene

Sources for IFNAR1 Gene

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