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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNAR1 Gene

protein-coding   GIFtS: 66
GCID: GC21P034696

interferon (alpha, beta and omega) receptor 1


(Previous symbol: IFNAR)
 Explore 39 diseases affiliated with
IFNAR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IFNAR1    

Aliases
for IFNAR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
Interferon (Alpha, Beta And Omega) Receptor 11 2     Human Interferon-Alpha Receptor (HuIFN-Alpha-Rec)11
IFNAR1 2 3     AVP2
IFRC1 2     IFN-Alpha-REC1
Cytokine Receptor Class-II Member 12 3     IFNBR2
Cytokine Receptor Family 2 Member 12 3     Alpha-Type Antiviral Protein2
Type I Interferon Receptor 12 3     Beta-Type Antiviral Protein2
CRF2-12 3     Interferon Alpha/Beta Receptor 12
IFN-R-12 3     Interferon-Alpha/Beta Receptor Alpha Chain2
IFN-Alpha/Beta Receptor 12 3     Interferon-Beta Receptor 12

External Ids:    HGNC: 54321   Entrez Gene: 34542   Ensembl: ENSG000001421667   OMIM: 1074505   UniProtKB: P171813   

Export aliases for IFNAR1 gene to outside databases

Previous GC identifers: GC21P031274 GC21P033617 GC21P033619 GC21P020166


Summaries
for IFNAR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IFNAR1:
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for
interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn
phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181
Function: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta.
Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins
and IFNR alpha- and beta-subunits themselves

summary for IFNAR1:
Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis
and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to
oxytocin receptors (OT). V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle
cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found
to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in
the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively
on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.

Gene Wiki entry for IFNAR1


Genomic Views
for IFNAR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFNAR1 gene promoter:
         LHX3b/Lhx3b   STAT1   AML1a   LHX3a/Lhx3a   STAT3   IRF-7A   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFNAR1 promoter sequence

   Search SABiosciences Chromatin IP Primers for IFNAR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
IFNAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNAR1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P034696:   GeneLoc Nature:405,311-319
Start:
 34,696,734 bp from pter       20,273,930 bp from centromere
End:
 34,732,168 bp from pter 20,305,504 bp from centromere
Size:
 35,435 bases 31,575 bases
Orientation:
 plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: X60459
genomic clones: pD71A4 PQ38G8


Proteins
for IFNAR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181 (See protein sequence)
Recommended Name: Interferon alpha/beta receptor 1 precursor  
Size: 557 amino acids; 63525 Da
Subunit: Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I
interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466.
Interacts with IFNAR2
Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAH02590.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence;
3 PDB 3D structures from and Proteopedia for IFNAR1:
3S98 (3D)        3SE3 (3D)        3SE4 (3D)    
Secondary accessions: B2R6L9 D3DSF0 Q53GW9 Q53H11 Q6PKD7 Q7M4L2 Q8WTZ2
Alternative splicing: 3 isoforms:  P17181-1   P17181-2   P17181-3   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for IFNAR1: NX_P17181

Post-translational modifications:

  • Phosphorylated on tyrosine residues by TYK2 tyrosine kinase1
  • Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17181

    • IFNAR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000620.2  
    ENSEMBL proteins: 
     ENSP00000270139   ENSP00000400161   ENSP00000407406   ENSP00000395606  
    Reactome Protein details: P17181
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for IFNAR1 (IFN-alpha/beta R1)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: IFNAR1
    OriGene Custom Protein Services for IFNAR1 
    GenScript Custom Purified and Recombinant Proteins Services for IFNAR1
    Novus Biologicals IFNAR1 Protein
    Novus Biologicals IFNAR1 Lysates
    Sino Biological Recombinant Protein for IFNAR1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8181059


    IFNAR1 for ontologies           About GeneDecksing



    IFNAR1 Antibody Products: 
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    ThermoFisher Antibodies for IFNAR1

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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for IFNAR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IFNAR1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003961 Fibronectin_type3
     IPR015373 Interferon_alpha/beta_rcpt_bsu
     IPR013783 Ig-like_fold
     IPR016669 Interferon_alpha/beta_rcpt-1

    Graphical View of Domain Structure for InterPro Entry P17181

    ProtoNet protein and cluster: P17181

    UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181
    Similarity: Belongs to the type II cytokine receptor family
    Similarity: Contains 3 fibronectin type-III domains


    Function
    for IFNAR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181
    Function: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta.
    Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins
    and IFNR alpha- and beta-subunits themselves

         Genatlas biochemistry entry for IFNAR1:
    interferon alpha/beta (type I),receptor (110kDa),alpha subunit conferring high affinity to the receptor,identified by
    monoclonal antibody IFNaR3,cytokine receptor family II member

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNAR1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNAR1:
    hsa-miR-141 hsa-miR-200a hsa-miR-4276 hsa-miR-3155 hsa-miR-3155b hsa-miR-570 hsa-miR-484
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNAR1 (see all 7)
    OriGene shRNA RFP: IFNAR1
    OriGene siRNA: IFNAR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNAR1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IFNAR1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNAR1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNAR1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IFNAR1 (NM_000629)
    Sino Biological Human cDNA Clone for IFNAR1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNAR1 

    Cell Line
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    Search LifeMap BioReagents cell lines for IFNAR1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNAR1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004904interferon receptor activity ----
    GO:0004905type I interferon receptor activity TAS7665574


    IFNAR1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for IFNAR1:
     Decreased Salmonella enterica   Increased G1 DNA content  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for IFNAR1: Ifnar1tm1Pjh Ifnar1tm1Agt
         15/16 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ifnar1) (see all 16):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     no phenotypic analysis  renal/urinary system  reproductive system  skeleton  tumorigenesis 

    IFNAR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IFNAR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of IFNA signaling
    		Regulation of IFNA signaling1.00
    		Immune response IFN alpha/beta signaling pathway0.71
    		Immune response_IFN alpha/beta signaling pathway0.71
    2Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    3Toll-like receptor signaling pathway
    		Toll-like receptor signaling pathway1.00
    		Toll-like receptor signaling pathway0.97
    4Measles
    		Measles1.00
    		Influenza A0.35
    5Immune System
    		Immune System1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for IFNAR1
        Immune response IFN alpha/beta signaling pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNAR1
        THC Differentiation Pathway
    Interferon Pathway
    JAK-STAT Pathway

    1 GeneGo (Thomson Reuters) Pathway for IFNAR1
        Immune response IFN alpha/beta signaling pathway

    3 BioSystems Pathways for IFNAR1 
        Toll-like receptor signaling pathway
    Osteoclast Signaling
    Downstream signaling in naive CD8+ T cells

    5        Reactome Pathways for IFNAR1
        Regulation of IFNA signaling
    Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System


    5/8         Kegg Pathways  (Kegg details for IFNAR1) (see all 8):
        Cytokine-cytokine receptor interaction
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    Jak-STAT signaling pathway
    Natural killer cell mediated cytotoxicity


    IFNAR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFNAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/60 Interacting proteins for IFNAR1 (P171812, 3 ENSP000002701394) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT2P526302, 3, ENSP000003157684MINT-8029458 MINT-8029443 MINT-8029473 MINT-8029488 MINT-8029503 I2D: score=5 STRING: ENSP00000315768
    TYK2P295972, 3, ENSP000002648184MINT-73134 I2D: score=6 STRING: ENSP00000264818
    IFNA13P015623, ENSP000003944944I2D: score=1 STRING: ENSP00000394494
    IFNA1P015623, ENSP000002769274I2D: score=1 STRING: ENSP00000276927
    PIK3R1P279863, ENSP000002743354I2D: score=3 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS7665574
    GO:0007259JAK-STAT cascade TAS7665574
    GO:0009615response to virus TAS2153461
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0032729positive regulation of interferon-gamma production IEA--


    IFNAR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IFNAR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IFNAR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for IFNAR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [Lys8]-VasopressinAntidiuretic hormone[50-57-7]
    d[Leu4,Lys8]-VP Selective V1B agonist[42061-33-6]
    [Arg8]-VasopressinAntidiuretic hormone[113-79-1]
    SR 49059 Selective, orally active vasopressin V1A receptor antagonist [150375-75-0]
    d[Cha4]-AVPPotent and selective human V1B agonist[500170-27-4]

    9 DrugBank Compounds for IFNAR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Peginterferon alfa-2b-- 99210-65-8targetagonist19955815 17139284 15898717 11752352 16953837 17016423
    Interferon alfa-n1Interferon alpha-2 (see all 3)74899-72-2targetagonist10822464 19955815 17139284 11752352 17016423
    Interferon alfa-n3-- --targetagonist19955815 17139284 15898717 11752352 17016423
    Interferon Alfa-2b, RecombinantInterferon alfa-2b (see all 2)99210-65-8targetbinder10567921 17139284 11752352 17016423
    Interferon alfacon-1CIFN (see all 9)118390-30-0targetbinder11752352 12528473 17016423 17139284
    Interferon beta-1aFibroblast interferon (see all 3)145258-61-3targetagonist11747625 10049744 16912135 12034032
    Peginterferon alfa-2a-- 198153-51-4targetagonist19955815 15898717 11752352 16953837
    Interferon Alfa-2a, RecombinantInterferon alfa-2a (see all 3)77907-69-8target--18230610 15898717
    Interferon beta-1bFibroblast interferon (see all 3)145155-23-3targetagonist11752352 10049744

    9 Novoseek chemical compound relationships for IFNAR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ifn-alpha 82.1 25 14532120 (3), 15287917 (2), 17873516 (2), 17627610 (2) (see all 14)
    poly(i-c) 49.1 1 19728309 (1)
    vero toxin 46.5 1 11133022 (1)
    tyrosine 42.4 25 7813427 (5), 8626489 (3), 7479825 (3), 8969169 (2) (see all 13)
    glycosphingolipid 27.6 4 10841076 (2)
    alanine 13.9 1 16171819 (1)
    5fluorouracil 13.7 1 17088986 (1)
    ribavirin 2.92 2 17823081 (2)
    serine 2.87 5 19948722 (1), 9029147 (1), 9677371 (1), 8626489 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about IFNAR1 / INAR1 

    Transcripts
    for IFNAR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IFNAR1 gene: 
    NM_000629.2  

    Unigene Cluster for IFNAR1:

    Interferon (alpha, beta and omega) receptor 1
    Hs.529400  [show with all ESTs]
    Unigene Representative Sequence: NM_000629
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493503 ENST00000270139(uc011adv.2 uc002yrn.3) ENST00000442071
    ENST00000442357 ENST00000416947

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    hsa-miR-141 hsa-miR-200a hsa-miR-4276 hsa-miR-3155 hsa-miR-3155b hsa-miR-570 hsa-miR-484
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    Inhib. RNA
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    OriGene shRNA RFP: IFNAR1
    OriGene siRNA: IFNAR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNAR1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNAR1 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: IFNAR1 (NM_000629)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNAR1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNAR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IFNAR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNAR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNAR1

    Additional cDNA sequence: 

    AK123813.1 AK222770.1 AK222812.1 AK298051.1 AK312631.1 BC002590.2 BC014338.1 BC021825.1 
    BC035603.1 BC065751.1 BX537636.1 DQ655972.2 DQ655973.3 J03171.1 

    12 DOTS entries:

    DT.95163268  DT.444906  DT.91779365  DT.100768129  DT.100768130  DT.100768134  DT.121131772  DT.121131784 
    DT.121131798  DT.97838815  DT.70100568  DT.95163267 

    24/241 AceView cDNA sequences (see all 241):

    BG819073 AA418297 AA448251 BM713024 BX107594 BM903878 AI141535 AW102927 
    H99298 BC002590 AI083512 AA687965 AI168179 AI371827 AI825009 BM452951 
    BU628689 BX487355 AU076883 AA447872 AI627581 AL707406 BG548299 BQ576101 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
    SP1:                                                                                                
    SP2:        -                                                                                       
    SP3:                                                                                      -         


    ECgene alternative splicing isoforms for IFNAR1

    Expression
    for IFNAR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFNAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGGAGCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IFNAR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFNAR1

    SOURCE GeneReport for Unigene cluster: Hs.529400

    UniProtKB/Swiss-Prot: INAR1_HUMAN, P17181
    Tissue specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells.
    Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and
    isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha
    resistant myeloma cell line U266R

        SABiosciences Expression via Pathway-Focused PCR Arrays including IFNAR1 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for IFNAR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IFNAR1 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IFNAR11 interferon (alpha, beta and omega) receptor 1 54.27(n)
    39.07(a)    		   395665  NM_204859.1  NP_990190.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IFNAR16
    		 --
    		 30(a)
    		 1 ↔ 1
    		 GL343628.1(308973-325361)
    zebrafish
    (Danio rerio)    		 Actinopterygii crfb51 cytokine receptor family member b5 41.37(n)
    32.48(a)    		   619391  NM_001034185.2  NP_001029357.2 


    ENSEMBL Gene Tree for IFNAR1 (if available)
    TreeFam Gene Tree for IFNAR1 (if available) 

    Paralogs
    for IFNAR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFNAR1 gene
    ENSG000002496242  IFNGR22  IL10RB2  

    IFNAR1 for paralogs           About GeneDecksing



    Genomic Variants
    for IFNAR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/756 NCBI SNPs in IFNAR1 are shown (see all 756)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1925591841,2
    		--34695378(+) ATATAC/TATGGA 1 -- us2k10--------
    rs1845369061,2
    		--34695391(+) ATATAG/TATATG 1 -- us2k10--------
    rs1885883451,2
    		--34695393(+) ATATAG/TATGGC 1 -- us2k10--------
    rs1813827681,2
    		--34695398(+) TATGGA/CATATA 1 -- us2k10--------
    rs1842288571,2
    		--34695406(+) ATATAC/TATGGA 1 -- us2k10--------
    rs1889544441,2
    		--34695419(+) ATATAG/TATATG 1 -- us2k10--------
    rs1817252181,2
    		--34695421(+) ATATAG/TATGGC 1 -- us2k10--------
    rs1872135891,2
    		--34695518(+) ATATAG/TATATG 1 -- us2k10--------
    rs1920885861,2
    		--34695520(+) ATATAG/TATGGC 1 -- us2k10--------
    rs1808976641,2
    		--34695534(+) TATATA/GTGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFNAR1 (34696734 - 34732168 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IFNAR1: --
    Human Gene Mutation Database (HGMD): IFNAR1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNAR1
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNAR1

    Disorders / Diseases
    for IFNAR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IFNAR1 for disorders           About GeneDecksing

    OMIM gene information: 107450    OMIM disorders: --

    20/39 diseases for IFNAR1 (see all 39):    About MalaCards
    cerebral amyloid angiopathy    rift valley fever    west nile virus    dengue hemorrhagic fever
    cervical intraepithelial neoplasia    hemorrhagic fever    hepatitis c    lupus erythematosus
    down syndrome    multiple sclerosis    chronic myeloid leukemia    burkitt's lymphoma
    myeloid leukemia    brain disease    bronchiolitis    renal cell carcinoma
    cblc    cerebritis    stomatitis    hepatitis b

    10/12 Novoseek disease relationships for IFNAR1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 48.5 7 19103527 (1), 18761606 (1), 19154989 (1), 9563926 (1) (see all 6)
    multiple sclerosis 47.5 5 15885318 (2), 18482773 (2)
    hepatitis c chronic 45.6 5 15107924 (2), 17823081 (1), 12141824 (1)
    cerebral amyloid angiopathy 43.8 5 2309274 (2), 7810298 (1), 2408196 (1)
    down syndrome 30.5 2 15487707 (2)
    hepatitis c 30.4 2 15990456 (1), 9563926 (1)
    lupus erythematosus systemic 10.3 1 18393399 (1)
    myeloma 8.51 5 8307198 (1), 7813427 (1), 14647450 (1)
    carcinoma renal cell 7.63 1 17697365 (1)
    brain diseases 7.44 2 2408196 (1)

    Genetic Association Database (GAD): IFNAR1
    Human Genome Epidemiology (HuGE) Navigator: IFNAR1 (38 documents)

    Export disorders for IFNAR1 gene to outside databases

    Publications
    for IFNAR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFNAR1 gene, integrated from 9 sources (see all 265):
    (articles sorted by number of sources associating them with IFNAR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. (PubMed id 12761564)1, 4, 9 Aucan C....Hill A.V. (2003)
    2. Palmitoylation of interferon-alpha (IFN-alpha) recept or subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alph a. (PubMed id 19561067)1, 2, 9 Claudinon J....Lamaze C. (2009)
    3. IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. (PubMed id 15885318)1, 4, 9 Leyva L....Matesanz F. (2005)
    4. Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. (PubMed id 12618863)1, 4, 9 Sriram U....Oksenberg J.R. (2003)
    5. The structure of the human interferon alpha/beta receptor gene. (PubMed id 1370833)1, 2, 9 Lutfalla G.... Uze G. (1992)
    6. Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation. (PubMed id 10049744)2, 7, 9 Russell-Harde D....Croze E. (1999)
    7. Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings. (PubMed id 15990456)1, 4, 9 Yoshida K....Miller A.H. (2005)
    8. LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density. (PubMed id 14727154)1, 4, 9 Mizuguchi T.... Yoshiura K. (2004)
    9. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for IFNAR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IFNAR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3454 HGNC: 5432 AceView: IFNAR1 Ensembl:ENSG00000142166 euGenes: HUgn3454
    ECgene: IFNAR1 Kegg: 3454 H-InvDB: IFNAR1

    Other Databases showing IFNAR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IFNAR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFNAR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IFNAR1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ifnar1/

    Intellectual Property
    for IFNAR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IFNAR1 gene:
    Search GeneIP for patents involving IFNAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IFNAR1 gene

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    About This Section

     
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