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Aliases for IFNAR1 Gene

Aliases for IFNAR1 Gene

  • Interferon Alpha And Beta Receptor Subunit 1 2 3
  • Interferon (Alpha, Beta And Omega) Receptor 1 2 3 5
  • Cytokine Receptor Class-II Member 1 3 4
  • Cytokine Receptor Family 2 Member 1 3 4
  • Type I Interferon Receptor 1 3 4
  • IFN-Alpha/Beta Receptor 1 3 4
  • IFN-R-1 3 4
  • CRF2-1 3 4
  • IFNAR 3 4
  • Interferon-Alpha/Beta Receptor Alpha Chain 3
  • Alpha-Type Antiviral Protein 3
  • Beta-Type Antiviral Protein 3
  • Interferon-Beta Receptor 1 3
  • Interferon Receptor 1 3
  • IFN-Alpha-REC 3
  • IFNBR 3
  • IFRC 3
  • AVP 3

External Ids for IFNAR1 Gene

Previous HGNC Symbols for IFNAR1 Gene

  • IFNAR

Previous GeneCards Identifiers for IFNAR1 Gene

  • GC21P031274
  • GC21P033617
  • GC21P033619
  • GC21P034696
  • GC21P020166

Summaries for IFNAR1 Gene

Entrez Gene Summary for IFNAR1 Gene

  • The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNAR1 Gene

IFNAR1 (Interferon Alpha And Beta Receptor Subunit 1) is a Protein Coding gene. Diseases associated with IFNAR1 include septicemic plague and hepatitis c. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include interferon receptor activity and type I interferon receptor activity. An important paralog of this gene is IL10RB.

UniProtKB/Swiss-Prot for IFNAR1 Gene

  • Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Gene Wiki entry for IFNAR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNAR1 Gene

Genomics for IFNAR1 Gene

Regulatory Elements for IFNAR1 Gene

Promoters for IFNAR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IFNAR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNAR1 Gene

Chromosome:
21
Start:
33,324,443 bp from pter
End:
33,359,862 bp from pter
Size:
35,420 bases
Orientation:
Plus strand

Genomic View for IFNAR1 Gene

Genes around IFNAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNAR1 Gene

Proteins for IFNAR1 Gene

  • Protein details for IFNAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17181-INAR1_HUMAN
    Recommended name:
    Interferon alpha/beta receptor 1
    Protein Accession:
    P17181
    Secondary Accessions:
    • B2R6L9
    • B4DNT3
    • D3DSF0
    • Q53GW9
    • Q53H11
    • Q6PKD7
    • Q7M4L2
    • Q8WTZ2

    Protein attributes for IFNAR1 Gene

    Size:
    557 amino acids
    Molecular mass:
    63525 Da
    Quaternary structure:
    • Heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466 (PubMed:9121453). Interacts with TYK2 (PubMed:7526154, PubMed:15337770, PubMed:24704786). Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:14532120, PubMed:15337770, PubMed:18056411). Interacts with SHMT2; this promotes interaction with FAM175B and the BRISC complex (PubMed:24075985).
    SequenceCaution:
    • Sequence=AAH02590.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IFNAR1 Gene

    Alternative splice isoforms for IFNAR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFNAR1 Gene

Proteomics data for IFNAR1 Gene at MOPED

Post-translational modifications for IFNAR1 Gene

  • Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.
  • Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination (PubMed:14532120, PubMed:15337770, PubMed:24075985). Phosphorylated on tyrosine residues by TYK2 tyrosine kinase (PubMed:7526154). Phosphorylated on tyrosine residues in response to interferon (PubMed:10049744).
  • Ubiquitinated, leading to its internalization and degradation (PubMed:14532120, PubMed:15337770). Polyubiquitinated via Lys-48-linked and Lys-63-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation (PubMed:18056411). The Lys-63-linked ubiquitin chains are cleaved off by the BRISC complex (PubMed:24075985).
  • Glycosylation at Asn 50, Asn 58, Asn 81, Asn 88, Asn 110, Asn 172, Asn 254, Asn 313, Asn 314, Asn 376, Asn 416, and Asn 433
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNAR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IFNAR1 (IFN-alpha/beta R1)

No data available for DME Specific Peptides for IFNAR1 Gene

Domains & Families for IFNAR1 Gene

Gene Families for IFNAR1 Gene

Protein Domains for IFNAR1 Gene

Suggested Antigen Peptide Sequences for IFNAR1 Gene

Graphical View of Domain Structure for InterPro Entry

P17181

UniProtKB/Swiss-Prot:

INAR1_HUMAN :
  • Contains 4 fibronectin type-III domains.
  • Belongs to the type II cytokine receptor family.
Domain:
  • Contains 4 fibronectin type-III domains.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IFNAR1: view

Function for IFNAR1 Gene

Molecular function for IFNAR1 Gene

GENATLAS Biochemistry:
interferon alpha/beta (type I),receptor (110kDa),alpha subunit conferring high affinity to the receptor,identified by monoclonal antibody IFNaR3,cytokine receptor family II member
UniProtKB/Swiss-Prot Function:
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
genes like me logo Genes that share phenotypes with IFNAR1: view

Animal Models for IFNAR1 Gene

MGI Knock Outs for IFNAR1:

Animal Model Products

miRNA for IFNAR1 Gene

miRTarBase miRNAs that target IFNAR1

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNAR1 Gene

Localization for IFNAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNAR1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Late endosome. Lysosome. Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes. {ECO:0000269 PubMed:14532120, ECO:0000269 PubMed:18056411}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNAR1 Gene COMPARTMENTS Subcellular localization image for IFNAR1 gene
Compartment Confidence
plasma membrane 5
endosome 4
lysosome 4
vacuole 4
cytosol 3
endoplasmic reticulum 2
extracellular 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFNAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005887 integral component of plasma membrane IEA,IDA 14532120
genes like me logo Genes that share ontologies with IFNAR1: view

Pathways & Interactions for IFNAR1 Gene

genes like me logo Genes that share pathways with IFNAR1: view

SIGNOR curated interactions for IFNAR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IFNAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS --
GO:0007259 JAK-STAT cascade TAS 7665574
GO:0009615 response to virus TAS 2153461
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0032729 positive regulation of interferon-gamma production IEA --
genes like me logo Genes that share ontologies with IFNAR1: view

Drugs & Compounds for IFNAR1 Gene

(25) Drugs for IFNAR1 Gene - From: DGIdb, DrugBank, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Interferon Alfa-2a, Recombinant Approved Pharma binder, Target 0
Interferon Alfa-2b, Recombinant Approved Pharma binder, Target 0
Interferon alfacon-1 Approved Pharma binder, Target 13
Interferon alfa-n1 Approved Pharma binder, Target, agonist 0
Interferon alfa-n3 Approved, Investigational Pharma binder, Target, agonist 0

(5) Additional Compounds for IFNAR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNAR1: view

Transcripts for IFNAR1 Gene

Unigene Clusters for IFNAR1 Gene

Interferon (alpha, beta and omega) receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1:
SP2: -
SP3: -

Relevant External Links for IFNAR1 Gene

GeneLoc Exon Structure for
IFNAR1
ECgene alternative splicing isoforms for
IFNAR1

Expression for IFNAR1 Gene

mRNA expression in normal human tissues for IFNAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFNAR1 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for IFNAR1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFNAR1 Gene



SOURCE GeneReport for Unigene cluster for IFNAR1 Gene Hs.529400

mRNA Expression by UniProt/SwissProt for IFNAR1 Gene

P17181-INAR1_HUMAN
Tissue specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
genes like me logo Genes that share expression patterns with IFNAR1: view

Protein tissue co-expression partners for IFNAR1 Gene

Primer Products

In Situ Assay Products

Orthologs for IFNAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNAR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFNAR1 35
  • 80.32 (n)
  • 67.51 (a)
IFNAR1 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100856529 35
  • 80.07 (n)
  • 70.47 (a)
-- 36
  • 67 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifnar1 35
  • 66.05 (n)
  • 50.83 (a)
Ifnar1 16
Ifnar1 36
  • 45 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IFNAR1 35
  • 99.46 (n)
  • 99.28 (a)
IFNAR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifnar1 35
  • 66.6 (n)
  • 52.35 (a)
oppossum
(Monodelphis domestica)
Mammalia IFNAR1 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFNAR1 36
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves IFNAR1 35
  • 54.39 (n)
  • 39.25 (a)
IFNAR1 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFNAR1 36
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498552 35
  • 46.45 (n)
  • 30.33 (a)
zebrafish
(Danio rerio)
Actinopterygii crfb5 35
  • 42.18 (n)
  • 33.33 (a)
crfb5 36
  • 19 (a)
OneToOne
Species with no ortholog for IFNAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFNAR1 Gene

ENSEMBL:
Gene Tree for IFNAR1 (if available)
TreeFam:
Gene Tree for IFNAR1 (if available)

Paralogs for IFNAR1 Gene

Paralogs for IFNAR1 Gene

genes like me logo Genes that share paralogs with IFNAR1: view

Variants for IFNAR1 Gene

Sequence variations from dbSNP and Humsavar for IFNAR1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2257167 - 33,343,393(+) GCTTA(C/G)TTATC reference, missense
rs17875833 - 33,349,221(+) TCCGC(A/C/G)TACAA downstream-variant-500B, reference, missense
rs17875834 - 33,349,476(+) AAACA(C/T)GCCTG downstream-variant-500B, reference, missense
rs1041429 -- 33,327,604(+) TGATT(A/G)TCCAC intron-variant
rs1041867 -- 33,354,946(+) GTGCT(G/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFNAR1 Gene

Variant ID Type Subtype PubMed ID
nsv834087 CNV Gain 17160897
esv268656 CNV Insertion 20981092
dgv4738n71 CNV Loss 21882294

Variation tolerance for IFNAR1 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.56; 77.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNAR1 Gene

HapMap Linkage Disequilibrium report
IFNAR1
Human Gene Mutation Database (HGMD)
IFNAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNAR1 Gene

Disorders for IFNAR1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for IFNAR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
septicemic plague
  • plague, septicemic
hepatitis c
  • chronic hepatitis c
stomatitis
multiple sclerosis, disease progression, modifier of
  • multiple sclerosis 1
viral infectious disease
  • arbovirus infectious disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IFNAR1

Genetic Association Database (GAD)
IFNAR1
Human Genome Epidemiology (HuGE) Navigator
IFNAR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNAR1
genes like me logo Genes that share disorders with IFNAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNAR1 Gene

Publications for IFNAR1 Gene

  1. A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection. (PMID: 18761606) Zhou J. … Zheng B.J. (J. Viral Hepat. 2009) 3 23 48 67
  2. Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor. (PMID: 19948722) Bhattacharya S. … Fuchs S.Y. (J. Biol. Chem. 2010) 3 23
  3. Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN- alpha. (PMID: 19561067) Claudinon J. … Lamaze C. (J. Biol. Chem. 2009) 3 23
  4. Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. (PMID: 19805514) Liu J. … Fuchs S.Y. (Mol. Cell. Biol. 2009) 3 23
  5. Ligand-independent pathway that controls stability of interferon alpha receptor. (PMID: 18166147) Liu J. … Fuchs S.Y. (Biochem. Biophys. Res. Commun. 2008) 3 23

Products for IFNAR1 Gene

Sources for IFNAR1 Gene

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