IFNA8 Gene
protein-coding GIFtS: 57
GCID: GC09P021409
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interferon, alpha 8
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Aliases
for IFNA8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon, Alpha 81 2 | | IFN-Alpha-81 | | IFN-AlphaB1 | | Interferon Alpha Type 2012 | | Interferon Alpha-B2 3 | | Interferon Alpha-82 | | Interferon Alpha-B22 3 | | Interferon Alpha-B'2 | | LeIF B2 3 | | |
Export aliases for IFNA8 gene to outside databasesPrevious GC identifers: GC09P021736 GC09P021610 GC09P021399 GC09P021372 |
Summaries
for IFNA8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IFNA8_HUMAN, P32881Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase
Gene Wiki entry for IFNA8
|
Genomic Views
for IFNA8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFNA8 gene promoter:
Egr-3 Egr-2 Brachyury LCR-F1 C/EBPalpha Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFNA8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22IFNA8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P021409: view genomic region
(about GC identifiers)
Start:
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21,409,146 bp from pter |
End:
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21,410,184 bp from pter |
Size:
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1,039 bases |
Orientation:
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plus strand |
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Proteins
for IFNA8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFNA8_HUMAN, P32881 (See
protein sequence)Recommended Name: Interferon alpha-8 precursor Size: 189 amino acids; 21989 Da
Subcellular location: Secreted
Secondary accessions: P01565 P09236 Q5VWV7 Q5VYQ3Explore the universe of human proteins at neXtProt for IFNA8: NX_P32881
IFNA8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002161.2
ENSEMBL proteins: ENSP00000369553 Reactome Protein details: P32881
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005615 | extracellular space |
IEA | -- |
IFNA8 for ontologies About GeneDecksing
IFNA8 Antibody Products:
Assay Products for IFNA8: |
Protein
Domains /
Families
for IFNA8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFNA8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P32881ProtoNet protein and cluster: P32881 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFNA8_HUMAN, P32881Similarity: Belongs to the alpha/beta interferon family |
Function
for IFNA8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IFNA8_HUMAN, P32881Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase Genatlas biochemistry entry for IFNA8:interferon type I,alpha 8,leukocyte
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNA8 (NM_002170) | |  | Sino Biological Human cDNA Clone for IFNA8 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA8 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- | | GO:0005126 | cytokine receptor binding |
IEA | -- |
IFNA8 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for IFNA8:
|
Pathways & Interactions
for IFNA8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of IFNA signaling | | | 2 | Toll-like receptor signaling pathway | | | 3 | Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway | | | 4 | Cytokine Signaling in Immune system | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for IFNA8
1  R&D Systems Pathway for IFNA8
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA8
2  GeneGo (Thomson Reuters) Pathways for IFNA8
1  BioSystems Pathway for IFNA8
5/11 
Reactome Pathways for IFNA8 (see all 11)
5/12 
Kegg Pathways (Kegg details for IFNA8) (see all 12):
IFNA8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/22 Interacting proteins for IFNA8 (P328813 ENSP000003695534) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
IFNA8 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFNA8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFNA8
Search CenterWatch for drugs/clinical trials and news about IFNA8
|
Transcripts
for IFNA8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFNA8 gene: NM_002170.3 Unigene Cluster for IFNA8: Interferon, alpha 8 Hs.73890 Unigene Representative Sequence: K019001 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000380205(uc003zpc.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IFNA8 (NM_002170) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA8 |
Additional cDNA sequence: BC104828.1 BC104830.1 K01900.1 V00545.1 V00550.1 1 DOTS entry: DT.208852 4 AceView cDNA sequences: V00550 V00545 K01900 NM_002170
GeneLoc Exon Structure
|
Expression
for IFNA8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFNA8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IFNA8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA8
SOURCE GeneReport for Unigene cluster: Hs.73890
SABiosciences Expression via Pathway-Focused PCR Arrays including IFNA8: | Interferons & Receptors in human mouse rat | | Inflammatory Response & Autoimmunity 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFNA8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA8 |
Orthologs
for IFNA8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFNA8 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for IFNA8 (if available)
TreeFam Gene Tree for IFNA8 (if available) |
Paralogs
for IFNA8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IFNA8 gene
- IFNA72 IFNA22 IFNE2 IFNA42 IFNA142 IFNA52 IFNK2 IFNA12
- IFNA212 IFNA172 IFNA62 IFNB12 IFNA132 IFNW12 IFNA162 IFNA102
18 SIMAP similar genes for IFNA8 using alignment to 1 protein entry: IFNA8_HUMAN:IFNA10 IFNA14 IFNA17 IFNA21 IFNA4 IFNA5
IFNA IFNA7 IFN-2 IFNA16 IFNA2 IFNA2B
IFNA6 IFNA1 IFNA13 IFNW1 IFNE IFNB1
IFNA8 for paralogs About GeneDecksing
|
Genomic Variants
for IFNA8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFNA8 (21409146 - 21410184 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFNA8
1 CNV: 8623 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA8 |
|
Disorders
/ Diseases
for IFNA8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFNA8 for disorders About GeneDecksing
OMIM gene information: 147568
OMIM disorders: --
15  diseases for IFNA8: About MalaCardsst. louis encephalitis dengue hemorrhagic fever hemorrhagic fever nodular malignant melanoma
bronchiolitis autoimmune thyroiditis hepatitis c hepatitis b
measles encephalitis hepatitis influenza
thyroiditis melanoma tuberculosis
1 disease from the University of Copenhagen DISEASES database for IFNA8:St. Louis encephalitis Human Genome Epidemiology (HuGE) Navigator: IFNA8 (7 documents)
Export disorders for IFNA8 gene to outside databases
|
Publications
for IFNA8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFNA8 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with IFNA8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population. (PubMed id 8836918)1, 2, 9 Hussain M.... Testa D. (1996)
- Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (1998)
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
- Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)1, 2 Henco K.... Weissmann C. (1985)
- Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes. (PubMed id 6325303)1, 2 Bowden D.W....Vovis G.F. (1984)
- The structure of eight distinct cloned human leukocyte interferon cDNAs. (PubMed id 6163083)1, 2 Goeddel D.V.... Gray P.W. (1981)
- Bacterial synthesis of a novel human leukocyte interferon. (PubMed id 6164048)1, 2 Yelverton E.... Goeddel D.V. (1981)
- Inhibitory effects of human immunodeficiency virus gp1 20 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cel ls. (PubMed id 22814248)1 Fang M....Yao H. (2012)
- HIV-1 Gag-virus-like particles inhibit HIV-1 replicati on in dendritic cells and T cells through IFN-a-dependent upregulation of APOBEC 3G and 3F. (PubMed id 22739040)1 Chang M.O....Takaku H. (2012)
- Reduced interferon (IFN)-a conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to sever e malarial anemia and longitudinal all-cause mortality. (PubMed id 22570109)1 Kempaiah P....Perkins D.J. (2012)
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External Searches for IFNA8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFNA8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFNA8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNA8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFNA8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IFNA8 gene:
Search GeneIP for patents involving IFNA8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFNA8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for IFNA8 | | OriGene shRNA RFP for IFNA8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNA8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA8 | | | OriGene Protein Over-expression Lysate for IFNA8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IFNA8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IFNA8 | | OriGene Custom Protein Services for IFNA8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNA8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA8 |
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 | | | | |  |  |  | | | | ThermoFisher Antibodies for IFNA8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA8 |
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