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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNA8 Gene

protein-coding   GIFtS: 60
GCID: GC09P021409

Interferon, Alpha 8

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Alpha 81 2     IFN-alpha-82 3
Interferon Alpha Type 2011 2     Interferon Alpha-B''1
Interferon Alpha-B2 3     IFN-alphaB2
Interferon Alpha-B22 3     Interferon Alpha-82
LeIF B2 3     Interferon Alpha-B'2

External Ids:    HGNC: 54291   Entrez Gene: 34452   Ensembl: ENSG000001202427   OMIM: 1475685   UniProtKB: P328813   

Export aliases for IFNA8 gene to outside databases

Previous GC identifers: GC09P021736 GC09P021610 GC09P021399 GC09P021372


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFNA8 Gene: 
IFNA8 (interferon, alpha 8) is a protein-coding gene. Diseases associated with IFNA8 include st. louis encephalitis, and dengue hemorrhagic fever, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include cytokine receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNA8_HUMAN, P32881
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFNA8 gene promoter:
         Egr-3   Egr-2   Brachyury   LCR-F1   C/EBPalpha   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNA8 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFNA8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA8 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P021409:  view genomic region     (about GC identifiers)

Start:
21,409,146 bp from pter      End:
21,410,184 bp from pter
Size:
1,039 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFNA8_HUMAN, P32881 (See protein sequence)
Recommended Name: Interferon alpha-8 precursor  
Size: 189 amino acids; 21989 Da
Subcellular location: Secreted
Secondary accessions: P01565 P09236 Q5VWV7 Q5VYQ3

Explore the universe of human proteins at neXtProt for IFNA8: NX_P32881

Explore proteomics data for IFNA8 at MOPED 

IFNA8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IFNA8 Protein Expression

REFSEQ proteins: NP_002161.2  
ENSEMBL proteins: 
 ENSP00000369553  
Reactome Protein details: P32881
Human Recombinant Protein Products for IFNA8: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IFNA8 (IFN-alpha B2)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for IFNA8
OriGene Custom MassSpec 
OriGene Custom Protein Services for IFNA8
GenScript Custom Purified and Recombinant Proteins Services for IFNA8
Novus Biologicals IFNA8 Proteins
Novus Biologicals IFNA8 Lysates
Sino Biological Recombinant Protein for IFNA8
Sino Biological Cell Lysate for IFNA8 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

IFNA8 for ontologies           About GeneDecksing



IFNA8 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for IFNA8
OriGene Custom Antibody Services for IFNA8
GenScript Custom Superior Antibodies Services for IFNA8
Novus Biologicals IFNA8 Antibodies
Abcam antibodies for IFNA8
Browse Antibodies at Cloud-Clone Corp. 
ThermoFisher Antibodies for IFNA8
LSBio Antibodies in human, mouse, rat for IFNA8 

Assay Products for IFNA8: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IFNA8
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for IFNA8
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IFN: Interferons

4 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR015589 Interferon_alpha
 IPR000471 Interferon_alpha/beta/delta
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P32881

ProtoNet protein and cluster: P32881

1 Blocks protein domain: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNA8_HUMAN, P32881
Similarity: Belongs to the alpha/beta interferon family


IFNA8 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IFNA8_HUMAN, P32881
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

     Genatlas biochemistry entry for IFNA8:
interferon type I,alpha 8,leukocyte

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005126cytokine receptor binding IEA--
     
IFNA8 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for IFNA8:
 Elongated cells 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNA8 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNA8

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNA8 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNA8 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA8
1 QIAGEN miScript miRNA Assays for microRNA that regulate IFNA8:
hsa-miR-570
SwitchGear 3'UTR luciferase reporter plasmidIFNA8 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IFNA8
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA8

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IFNA8
Sirion Biotech Customized adenovirus for overexpression of IFNA8

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IFNA8 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNA8 (NM_002170)
Sino Biological Human cDNA Clone for IFNA8
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA8
Sirion Biotech Customized lentivirus for stable overexpression of IFNA8 
                     Customized lentivirus expression plasmids for stable overexpression of IFNA8 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IFNA8
Search LifeMap BioReagents cell lines for IFNA8
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA8


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IFNA8 About   (see all 24)                                                                                              See pathways by source

SuperPathContained pathways About
1Toll-like receptor signaling pathway
Toll-like receptor signaling pathway0.93
Hepatitis B0.31
Toll-like receptor signaling pathway0.93
2Immune response IFN alpha/beta signaling pathway
Immune response IFN alpha/beta signaling pathway0.71
Interferon alpha/beta signaling0.45
Regulation of IFNA signaling0.71
3Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
RIG-I-like receptor signaling pathway0.52
5Influenza A
Influenza A0.34
Herpes simplex infection0.33
Measles0.34

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for IFNA8
    Immune response IFN alpha/beta signaling pathway
Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

2 R&D Systems Pathways for IFNA8
    NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA8
    Cytokine Network
Interferon Pathway
JAK-STAT Pathway
all-trans-Retinoic Acid Mediated Apoptosis

2 GeneGo (Thomson Reuters) Pathways for IFNA8
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
Immune response IFN alpha/beta signaling pathway

1 BioSystems Pathway for IFNA8
    Toll-like receptor signaling pathway


5/10        Reactome Pathways for IFNA8 (see all 10)
    Hemostasis
Regulation of IFNA signaling
Interferon alpha/beta signaling
Cytokine Signaling in Immune system
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways


5/15         Kegg Pathways  (Kegg details for IFNA8) (see all 15):
    Cytokine-cytokine receptor interaction
Regulation of autophagy
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway


IFNA8 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA8

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/22 Interacting proteins for IFNA8 (P328813 ENSP000003695534) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
InteractantInteraction Details
GeneCardExternal ID(s)
IFNAR2P485513, ENSP000003439574I2D: score=1 STRING: ENSP00000343957
IFNA14ENSP000003695714STRING: ENSP00000369571
IFNA16ENSP000003695644STRING: ENSP00000369564
IFNA2ENSP000003695544STRING: ENSP00000369554
IFNA6ENSP000003695584STRING: ENSP00000369558
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006952defense response ----
GO:0007596blood coagulation TAS--
GO:0019221cytokine-mediated signaling pathway TAS--
GO:0045087innate immune response TAS--
GO:0051607defense response to virus IEA--

IFNA8 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNA8

Search CenterWatch for drugs/clinical trials and news about IFNA8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNA8 gene: 
NM_002170.3  

Unigene Cluster for IFNA8:

Interferon, alpha 8
Hs.73890
Unigene Representative Sequence: K01900
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000380205(uc003zpc.1)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA8
1 QIAGEN miScript miRNA Assays for microRNA that regulate IFNA8:
hsa-miR-570
SwitchGear 3'UTR luciferase reporter plasmidIFNA8 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IFNA8
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA8
Clone
Products:
     
OriGene clones in human, mouse for IFNA8 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNA8 (NM_002170)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA8
Sirion Biotech Customized lentivirus for stable overexpression of IFNA8 
                     Customized lentivirus expression plasmids for stable overexpression of IFNA8 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for IFNA8
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFNA8
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA8
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA8

Additional mRNA sequence: 

BC104828.1 BC104830.1 K01900.1 V00545.1 V00550.1 

1 DOTS entry:

DT.208852 

4 AceView cDNA sequences:

V00550 V00545 NM_002170 K01900 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNA8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IFNA8 Expression
About this image


See IFNA8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA8

SOURCE GeneReport for Unigene cluster: Hs.73890
    SABiosciences Expression via Pathway-Focused PCR Arrays including IFNA8: 
          Interferons & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for IFNA8
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFNA8
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA8
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA8
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for IFNA8 (if available)
TreeFam Gene Tree for IFNA8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IFNA8 gene
IFNA72  IFNA22  IFNA42  IFNE2  IFNA142  IFNA52  IFNK2  IFNA12  
IFNA212  IFNA172  IFNA62  IFNB12  IFNA132  IFNW12  IFNA162  IFNA102  
18 SIMAP similar genes for IFNA8 using alignment to 1 protein entry:     IFNA8_HUMAN:
IFNA10    IFNA14    IFNA17    IFNA21    IFNA4    IFNA5
IFNA    IFNA7    IFN-2    IFNA16    IFNA2    IFNA2B
IFNA6    IFNA1    IFNA13    IFNW1    IFNE    IFNB1

IFNA8 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/123 SNPs in IFNA8 are shown (see all 123)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs13303221,2
C,F,O,A,H--21407250(-) ATTGCG/ATGTTA 1 -- us2k126Minor allele frequency- A:0.40NS EA NA WA CSA 2562
rs1886098961,2
--21407251(+) AACATA/GCAATA 1 -- us2k10--------
rs41424001,2
H--21407319(+) TCCATT/Gctaca 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
rs13303211,2
C,F,H--21407375(-) AAACAT/CAAGAC 1 -- us2k120Minor allele frequency- C:0.10NS EA NA WA 2270
rs727013581,2
C--21407510(+) GCACCA/GTTTTG 1 -- us2k10--------
rs1836367061,2
--21407524(+) CTGCTC/TTTCCT 1 -- us2k10--------
rs283837841,2
C,F--21407565(+) AATATC/GCAAGT 1 -- us2k11Minor allele frequency- G:0.24EA 120
rs49781151,2
C,F,A,H--21407604(+) GGGATA/GTTACT 1 -- us2k121Minor allele frequency- G:0.31NS EA NA CSA WA 3696
rs49781161,2
C,F,A,H--21407638(+) TTTAGG/TTATAC 1 -- us2k112Minor allele frequency- T:0.47NS EA NA WA CSA 782
rs802427681,2
C,F--21407663(+) TGCTCT/CCATTT 1 -- us2k11Minor allele frequency- C:0.10EA 120

HapMap Linkage Disequilibrium report for IFNA8 (21409146 - 21410184 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for IFNA8:    About this table     
Variant IDTypeSubtypePubMed ID
nsv892724CNV Gain21882294
nsv466297CNV Gain19166990
nsv892738CNV Gain21882294
nsv892739CNV Gain21882294
esv2752289CNV Gain17911159

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IFNA8
DNA2.0 Custom Variant and Variant Library Synthesis for IFNA8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147568    OMIM disorders: --

17 diseases for IFNA8:    About MalaCards
st. louis encephalitis    dengue hemorrhagic fever    nodular malignant melanoma    hemorrhagic fever
measles    hiv/aids    autoimmune thyroiditis    encephalitis
bronchiolitis    hepatitis c    influenza    hepatitis b
melanoma    hepatitis    thyroiditis    anemia
tuberculosis

1 disease from the University of Copenhagen DISEASES database for IFNA8:
St. Louis encephalitis

IFNA8 for disorders           About GeneDecksing

Genetic Association Database (GAD): IFNA8
Human Genome Epidemiology (HuGE) Navigator: IFNA8 (7 documents)

Export disorders for IFNA8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IFNA8 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with IFNA8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population. (PubMed id 8836918)1, 2, 9 Hussain M.... Testa D. (1996)
  2. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
  3. Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (2010)
  4. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)
  5. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
  6. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
  7. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
  8. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (1998)
  9. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
  10. Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)1, 2 Henco K.... Weissmann C. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3445 HGNC: 5429 AceView: IFNA8 Ensembl:ENSG00000120242 euGenes: HUgn3445
ECgene: IFNA8 Kegg: 3445 H-InvDB: IFNA8

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IFNA8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IFNA8 gene:
Search GeneIP for patents involving IFNA8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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