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IFNA8 Gene

protein-coding   GIFtS: 59
GCID: GC09P021409

Interferon, Alpha 8

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Alpha 81 2     IFN-alpha-82 3
Interferon Alpha Type 2011 2     Interferon Alpha-B''1
Interferon Alpha-B2 3     IFN-alphaB2
Interferon Alpha-B22 3     Interferon Alpha-82
LeIF B2 3     Interferon Alpha-B'2

External Ids:    HGNC: 54291   Entrez Gene: 34452   Ensembl: ENSG000001202427   OMIM: 1475685   UniProtKB: P328813   

Export aliases for IFNA8 gene to outside databases

Previous GC identifers: GC09P021736 GC09P021610 GC09P021399 GC09P021372


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFNA8 Gene:
IFNA8 (interferon, alpha 8) is a protein-coding gene. Diseases associated with IFNA8 include st. louis encephalitis, and nodular malignant melanoma. GO annotations related to this gene include cytokine receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNA8_HUMAN, P32881
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFNA8 gene promoter:
         Egr-3   Egr-2   Brachyury   LCR-F1   C/EBPalpha   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNA8 promoter sequence
   Search Chromatin IP Primers for IFNA8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA8 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P021409:  view genomic region     (about GC identifiers)

Start:
21,409,146 bp from pter      End:
21,410,184 bp from pter
Size:
1,039 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IFNA8_HUMAN, P32881 (See protein sequence)
Recommended Name: Interferon alpha-8 precursor  
Size: 189 amino acids; 21989 Da
Secondary accessions: P01565 P09236 Q5VWV7 Q5VYQ3

Explore the universe of human proteins at neXtProt for IFNA8: NX_P32881

Explore proteomics data for IFNA8 at MOPED


See IFNA8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002161.2  
ENSEMBL proteins: 
 ENSP00000369553  
Reactome Protein details: P32881

IFNA8 Human Recombinant Protein Products:

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R&D Systems Recombinant & Natural Proteins for IFNA8 (IFN-alpha B2)
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OriGene Protein Over-expression Lysate for IFNA8
OriGene Custom MassSpec
OriGene Custom Protein Services for IFNA8
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Novus Biologicals IFNA8 Proteins
Novus Biologicals IFNA8 Lysates
Sino Biological Recombinant Protein for IFNA8
Sino Biological Cell Lysate for IFNA8
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

IFNA8 Antibody Products:

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OriGene Antibodies for IFNA8
OriGene Custom Antibody Services for IFNA8
Novus Biologicals IFNA8 Antibodies
Abcam antibodies for IFNA8
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for IFNA8
LSBio Antibodies in human, mouse, rat for IFNA8

IFNA8 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IFNA8
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for IFNA8
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IFN: Interferons

4 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR015589 Interferon_alpha
 IPR000471 Interferon_alpha/beta/delta
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P32881

ProtoNet protein and cluster: P32881

1 Blocks protein domain: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNA8_HUMAN, P32881
Similarity: Belongs to the alpha/beta interferon family


IFNA8 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IFNA8_HUMAN, P32881
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

     Genatlas biochemistry entry for IFNA8:
interferon type I,alpha 8,leukocyte

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IBA--
GO:0005126cytokine receptor binding TAS6163083
GO:0005132type I interferon receptor binding IBA--
     
IFNA8 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for IFNA8:
 Elongated cells 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFNA8
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFNA8

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNA8
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNA8

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat IFNA8 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate IFNA8:
hsa-miR-570
SwitchGear 3'UTR luciferase reporter plasmidIFNA8 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for IFNA8
Predesigned siRNA for gene silencing in human, mouse, rat IFNA8

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IFNA8

Clone
Products:
     
OriGene clones in human, mouse for IFNA8 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNA8 (NM_002170)
Sino Biological Human cDNA Clone for IFNA8
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA8

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IFNA8
Browse ESI BIO Cell Lines and PureStem Progenitors for IFNA8 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IFNA8_HUMAN, P32881: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IBA--

IFNA8 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IFNA8 About   (see all 21)  
See pathways by source

SuperPathContained pathways About
1Toll-like receptor signaling pathway
Toll-like receptor signaling pathway0.94
Regulation of toll-like receptor signaling pathway0.93
Toll-like receptor signaling pathway0.94
Hepatitis B0.31
2Immune response IFN alpha beta signaling pathway
Immune response IFN alpha beta signaling pathway0.69
Interferon alpha/beta signaling0.43
Regulation of IFNA signaling0.69
3NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways0.58
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
NOD-like Receptor Signaling Pathways0.58
4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
TRAF6 mediated IRF7 activation0.40
RIG-I-like receptor signaling pathway0.47
5Influenza A
Influenza A0.34
Herpes simplex infection0.33
Measles0.34

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 R&D Systems Pathways for IFNA8
    NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways

4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IFNA8
    Cytokine Network
Interferon Pathway
JAK-STAT Pathway
all-trans-Retinoic Acid Mediated Apoptosis

2 GeneGo (Thomson Reuters) Pathways for IFNA8
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
Immune response IFN alpha/beta signaling pathway

2 BioSystems Pathways for IFNA8
    Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathway


4 Reactome Pathways for IFNA8
    Regulation of IFNA signaling
Interferon alpha/beta signaling
Factors involved in megakaryocyte development and platelet production
TRAF6 mediated IRF7 activation


Selected Kegg Pathways  (Kegg details for IFNA8) (see all 15):
    Cytokine-cytokine receptor interaction
Regulation of autophagy
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway


IFNA8 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNA8: 
          Interferons & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for IFNA8

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

Selected Interacting proteins for IFNA8 (P328813 ENSP000003695534) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
InteractantInteraction Details
GeneCardExternal ID(s)
IFNAR2P485513, ENSP000003439574I2D: score=1 STRING: ENSP00000343957
IFNA14ENSP000003695714STRING: ENSP00000369571
IFNA16ENSP000003695644STRING: ENSP00000369564
IFNA2ENSP000003695544STRING: ENSP00000369554
IFNA6ENSP000003695584STRING: ENSP00000369558
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Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002250adaptive immune response IBA--
GO:0002286T cell activation involved in immune response IBA--
GO:0002323natural killer cell activation involved in immune response IBA--
GO:0006952defense response ----
GO:0006959humoral immune response IBA--

IFNA8 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IFNA8



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IFNA8 gene: 
NM_002170.3  

Unigene Cluster for IFNA8:

Interferon, alpha 8
Hs.73890
Unigene Representative Sequence: K01900
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000380205(uc003zpc.1)
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat IFNA8 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate IFNA8:
hsa-miR-570
SwitchGear 3'UTR luciferase reporter plasmidIFNA8 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for IFNA8
Predesigned siRNA for gene silencing in human, mouse, rat IFNA8
Clone
Products:
     
OriGene clones in human, mouse for IFNA8 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNA8 (NM_002170)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA8
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for IFNA8
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFNA8
  QuantiTect SYBR Green Assays in human, mouse, rat IFNA8
  QuantiFast Probe-based Assays in human, mouse, rat IFNA8

Additional mRNA sequence: 

BC104828.1 BC104830.1 K01900.1 V00545.1 V00550.1 

1 DOTS entry:

DT.208852 

4 AceView cDNA sequences:

V00550 V00545 K01900 NM_002170 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IFNA8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IFNA8 Expression
About this image

IFNA8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IFNA8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.73890
    Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNA8: 
          Interferons & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for IFNA8
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFNA8
QuantiTect SYBR Green Assays in human, mouse, rat IFNA8
QuantiFast Probe-based Assays in human, mouse, rat IFNA8
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for IFNA8 (if available)
TreeFam Gene Tree for IFNA8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IFNA8 gene
IFNA72  IFNA22  IFNA42  IFNE2  IFNA142  IFNA52  IFNK2  IFNA12  
IFNA212  IFNA172  IFNA62  IFNB12  IFNA132  IFNW12  IFNA162  IFNA102  
18 SIMAP similar genes for IFNA8 using alignment to 1 protein entry:     IFNA8_HUMAN:
IFNA10    IFNA14    IFNA17    IFNA21    IFNA4    IFNA5
IFNA    IFNA7    IFN-2    IFNA16    IFNA2    IFNA2B
IFNA6    IFNA1    IFNA13    IFNW1    IFNE    IFNB1

IFNA8 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IFNA8 (see all 123)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs13303221,2
C,F,O,A,H--21407250(-) ATTGCG/ATGTTA 1 -- us2k126Minor allele frequency- A:0.40NS EA NA WA CSA 2562
rs1886098961,2
--21407251(+) AACATA/GCAATA 1 -- us2k10--------
rs41424001,2
H--21407319(+) TCCATT/Gctaca 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
rs13303211,2
C,F,H--21407375(-) AAACAT/CAAGAC 1 -- us2k120Minor allele frequency- C:0.10NS EA NA WA 2270
rs727013581,2
C--21407510(+) GCACCA/GTTTTG 1 -- us2k10--------
rs1836367061,2
--21407524(+) CTGCTC/TTTCCT 1 -- us2k10--------
rs283837841,2
C,F--21407565(+) AATATC/GCAAGT 1 -- us2k11Minor allele frequency- G:0.24EA 120
rs49781151,2
C,F,A,H--21407604(+) GGGATA/GTTACT 1 -- us2k121Minor allele frequency- G:0.31NS EA NA CSA WA 3696
rs49781161,2
C,F,A,H--21407638(+) TTTAGG/TTATAC 1 -- us2k112Minor allele frequency- T:0.47NS EA NA WA CSA 782
rs802427681,2
C,F--21407663(+) TGCTCT/CCATTT 1 -- us2k11Minor allele frequency- C:0.10EA 120

HapMap Linkage Disequilibrium report for IFNA8 (21409146 - 21410184 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for IFNA8:    About this table    
Variant IDTypeSubtypePubMed ID
nsv892724CNV Gain21882294
nsv466297CNV Gain19166990
nsv892738CNV Gain21882294
nsv892739CNV Gain21882294
esv2752289CNV Gain17911159

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IFNA8
DNA2.0 Custom Variant and Variant Library Synthesis for IFNA8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147568    OMIM disorders: --

20 diseases for IFNA8:    
About MalaCards
st. louis encephalitis    nodular malignant melanoma    hiv/aids    dengue hemorrhagic fever
hemorrhagic fever    measles    autoimmune thyroiditis    encephalitis
bronchiolitis    hiv-1    cutaneous malignant melanoma    hepatitis c virus
influenza    hepatitis c    hepatitis b    tuberculosis
melanoma    hepatitis    thyroiditis    herpes simplex

1 disease from the University of Copenhagen DISEASES database for IFNA8:
St. Louis encephalitis

IFNA8 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Genetic Association Database (GAD): IFNA8
Human Genome Epidemiology (HuGE) Navigator: IFNA8 (7 documents)

Export disorders for IFNA8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IFNA8 gene, integrated from 10 sources (see all 75):
(articles sorted by number of sources associating them with IFNA8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population. (PubMed id 8836918)1, 2, 9 Hussain M.... Testa D. (J. Interferon Cytokine Res. 1996)
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
  3. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (Fam. Cancer 2010)
  4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  6. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  7. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
  8. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (Biochem. J. 1998)
  9. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (Genomics 1992)
  10. Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)1, 2 Henco K.... Weissmann C. (J. Mol. Biol. 1985)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3445 HGNC: 5429 AceView: IFNA8 Ensembl:ENSG00000120242 euGenes: HUgn3445
ECgene: IFNA8 Kegg: 3445 H-InvDB: IFNA8

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IFNA8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IFNA8 gene:
Search GeneIP for patents involving IFNA8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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