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Aliases for IFNA8 Gene

Aliases for IFNA8 Gene

  • Interferon Alpha 8 2 3 5
  • Interferon Alpha-B 2 3 4
  • Interferon Alpha Type 201 2 3
  • Interferon Alpha-B2 3 4
  • IFN-Alpha-8 3 4
  • LeIF B 3 4
  • Interferon, Alpha 8 2
  • Interferon Alpha-8 3
  • IFN-AlphaB 3

External Ids for IFNA8 Gene

Previous GeneCards Identifiers for IFNA8 Gene

  • GC09P021736
  • GC09P021610
  • GC09P021399
  • GC09P021372

Summaries for IFNA8 Gene

GeneCards Summary for IFNA8 Gene

IFNA8 (Interferon Alpha 8) is a Protein Coding gene. Diseases associated with IFNA8 include St. Louis Encephalitis. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA5.

UniProtKB/Swiss-Prot for IFNA8 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA8 Gene

Genomics for IFNA8 Gene

Regulatory Elements for IFNA8 Gene

Enhancers for IFNA8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F021252 1 Ensembl ENCODE 11.7 -155.9 -155944 0.8 CTCF PKNOX1 ZNF654 TRIM22 RAD21 SMARCA4 SMC3 PRDM1 IFNA12P IFNA8 IFNWP2 IFNA13 IFNA20P IFNA14 IFNA22P
GH09F021450 0.2 ENCODE 11.5 +42.4 42436 1.4 CEBPB NFE2L2 IFNWP2 IFNA8 IFNA12P IFNA13 IFNA5 IFNWP19
GH09F021334 0.5 ENCODE 11.1 -74.1 -74060 1.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 IFNA13 IFNA5 IFNA12P IFNA8 IFNWP2 KLHL9 IFNA20P
GH09F021333 0.2 ENCODE 11 -75.2 -75151 0.2 CHD1 IFNA13 IFNA5 IFNA12P IFNA8 IFNWP2 KLHL9 IFNA20P
GH09F021268 0.4 Ensembl 10.8 -140.9 -140947 0.4 MTA2 IKZF1 CBX2 BMI1 EBF1 TBX21 SPI1 IFNA5 IFNA12P IFNA8 IFNWP2 IFNA13 MIR31 IFNA22P IFNA14
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IFNA8 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNA8 Gene

Chromosome:
9
Start:
21,409,147 bp from pter
End:
21,410,185 bp from pter
Size:
1,039 bases
Orientation:
Plus strand

Genomic View for IFNA8 Gene

Genes around IFNA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA8 Gene

Proteins for IFNA8 Gene

  • Protein details for IFNA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32881-IFNA8_HUMAN
    Recommended name:
    Interferon alpha-8
    Protein Accession:
    P32881
    Secondary Accessions:
    • P01565
    • P09236
    • Q5VWV7
    • Q5VYQ3

    Protein attributes for IFNA8 Gene

    Size:
    189 amino acids
    Molecular mass:
    21989 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA8 Gene

Post-translational modifications for IFNA8 Gene

No Post-translational modifications

Other Protein References for IFNA8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IFNA8 Gene

Domains & Families for IFNA8 Gene

Gene Families for IFNA8 Gene

Suggested Antigen Peptide Sequences for IFNA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32881

UniProtKB/Swiss-Prot:

IFNA8_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA8: view

Function for IFNA8 Gene

Molecular function for IFNA8 Gene

GENATLAS Biochemistry:
interferon type I,alpha 8,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IBA --
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA8: view
genes like me logo Genes that share phenotypes with IFNA8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA8 Gene

Localization for IFNA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA8 Gene COMPARTMENTS Subcellular localization image for IFNA8 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with IFNA8: view

Pathways & Interactions for IFNA8 Gene

genes like me logo Genes that share pathways with IFNA8: view

Gene Ontology (GO) - Biological Process for IFNA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA8: view

No data available for SIGNOR curated interactions for IFNA8 Gene

Transcripts for IFNA8 Gene

mRNA/cDNA for IFNA8 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA8 Gene

No ASD Table

Relevant External Links for IFNA8 Gene

GeneLoc Exon Structure for
IFNA8
ECgene alternative splicing isoforms for
IFNA8

Expression for IFNA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA8 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA8 Gene

This gene is overexpressed in Brain - Cerebellum (x16.1), Brain - Cerebellar Hemisphere (x13.4), and Brain - Frontal Cortex (BA9) (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of IFNA8 Gene:

IFNA8

SOURCE GeneReport for Unigene cluster for IFNA8 Gene:

Hs.73890
genes like me logo Genes that share expression patterns with IFNA8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IFNA8 Gene

Orthologs for IFNA8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA8 34 35
  • 98.94 (n)
mouse
(Mus musculus)
Mammalia Ifna6 35
  • 64 (a)
ManyToMany
Ifna12 35
  • 63 (a)
ManyToMany
Ifna13 35
  • 63 (a)
ManyToMany
Ifna5 35
  • 63 (a)
ManyToMany
Gm12597 35
  • 62 (a)
ManyToMany
Ifna1 35
  • 62 (a)
ManyToMany
Ifna2 35
  • 61 (a)
ManyToMany
Ifna9 35
  • 61 (a)
ManyToMany
Ifnab 35
  • 61 (a)
ManyToMany
Gm13280 35
  • 60 (a)
ManyToMany
Ifna14 35
  • 60 (a)
ManyToMany
Ifna7 35
  • 60 (a)
ManyToMany
Ifna11 35
  • 59 (a)
ManyToMany
Ifna4 35
  • 58 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 61 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
IFNAG 35 35
  • 60 (a)
ManyToMany
IFNAA 35
  • 59 (a)
ManyToMany
IFNAH 35
  • 59 (a)
ManyToMany
INFAF 35
  • 59 (a)
ManyToMany
Species where no ortholog for IFNA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA8 Gene

ENSEMBL:
Gene Tree for IFNA8 (if available)
TreeFam:
Gene Tree for IFNA8 (if available)

Paralogs for IFNA8 Gene

(18) SIMAP similar genes for IFNA8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA8: view

Variants for IFNA8 Gene

Sequence variations from dbSNP and Humsavar for IFNA8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10738592 -- 21,408,517(+) TGTTA(C/T)AGGAA upstream-variant-2KB
rs10811535 -- 21,407,697(+) CTTTT(G/T)CTTTC upstream-variant-2KB
rs10811536 -- 21,408,694(+) ATATA(C/T)ACTAG upstream-variant-2KB
rs10811537 -- 21,408,825(+) TTGTT(C/T)TCTAA upstream-variant-2KB
rs10964981 -- 21,408,293(+) GCTTA(A/T)GTTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNA8 Gene

Variant ID Type Subtype PubMed ID
esv2752289 CNV gain 17911159
esv2764150 CNV gain+loss 21179565
nsv466297 CNV gain 19166990
nsv613758 CNV gain 21841781
nsv968603 CNV duplication 23825009

Variation tolerance for IFNA8 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA8 Gene

Disorders for IFNA8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNA8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
st. louis encephalitis
  • neuroinvasive st. louis encephalitis virus infection
- elite association - COSMIC cancer census association via MalaCards
Search IFNA8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFNA8

Genetic Association Database (GAD)
IFNA8
Human Genome Epidemiology (HuGE) Navigator
IFNA8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA8
genes like me logo Genes that share disorders with IFNA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA8 Gene

Publications for IFNA8 Gene

  1. Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population. (PMID: 8836918) Hussain M. … Testa D. (J. Interferon Cytokine Res. 1996) 3 4 22 64
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64
  4. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 46 64
  5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 64

Products for IFNA8 Gene

Sources for IFNA8 Gene

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