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Aliases for IFNA7 Gene

Aliases for IFNA7 Gene

  • Interferon, Alpha 7 2 3 5
  • Interferon Alpha-J1 3 4
  • Interferon Alpha-J 3 4
  • IFN-Alpha-J1 3 4
  • IFN-Alpha-7 3 4
  • LeIF J 3 4
  • IFN-Alpha 7 3
  • IFN-AlphaJ 3
  • IFNA-J 3

External Ids for IFNA7 Gene

Previous GeneCards Identifiers for IFNA7 Gene

  • GC09M021529
  • GC09M021402
  • GC09M021191
  • GC09M021214
  • GC09M021224
  • GC09M021164
  • GC09M021228
  • GC09M021234
  • GC09M021237
  • GC09M021241
  • GC09M021244
  • GC09M021247
  • GC09M021251
  • GC09M021256
  • GC09M021261

Summaries for IFNA7 Gene

GeneCards Summary for IFNA7 Gene

IFNA7 (Interferon, Alpha 7) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Allograft rejection. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA7 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA7 Gene

Genomics for IFNA7 Gene

Regulatory Elements for IFNA7 Gene

Enhancers for IFNA7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFNA7 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNA7 Gene

Chromosome:
9
Start:
21,201,469 bp from pter
End:
21,202,205 bp from pter
Size:
737 bases
Orientation:
Minus strand

Genomic View for IFNA7 Gene

Genes around IFNA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA7 Gene

Proteins for IFNA7 Gene

  • Protein details for IFNA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01567-IFNA7_HUMAN
    Recommended name:
    Interferon alpha-7
    Protein Accession:
    P01567
    Secondary Accessions:
    • Q14607
    • Q5VV14

    Protein attributes for IFNA7 Gene

    Size:
    189 amino acids
    Molecular mass:
    22107 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA7 Gene

Proteomics data for IFNA7 Gene at MOPED

Post-translational modifications for IFNA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IFNA7
  • Cloud-Clone Corp. Antibodies for IFNA7
  • Santa Cruz Biotechnology (SCBT) Antibodies for IFNA7

No data available for DME Specific Peptides for IFNA7 Gene

Domains & Families for IFNA7 Gene

Gene Families for IFNA7 Gene

Suggested Antigen Peptide Sequences for IFNA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01567

UniProtKB/Swiss-Prot:

IFNA7_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA7: view

Function for IFNA7 Gene

Molecular function for IFNA7 Gene

GENATLAS Biochemistry:
interferon type I,alpha 7,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
genes like me logo Genes that share phenotypes with IFNA7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA7 Gene

Localization for IFNA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA7 Gene COMPARTMENTS Subcellular localization image for IFNA7 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for IFNA7 Gene

Pathways & Interactions for IFNA7 Gene

genes like me logo Genes that share pathways with IFNA7: view

Gene Ontology (GO) - Biological Process for IFNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
GO:0007267 cell-cell signaling TAS 2995168
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with IFNA7: view

No data available for SIGNOR curated interactions for IFNA7 Gene

Drugs & Compounds for IFNA7 Gene

No Compound Related Data Available

Transcripts for IFNA7 Gene

mRNA/cDNA for IFNA7 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA7 Gene

No ASD Table

Relevant External Links for IFNA7 Gene

GeneLoc Exon Structure for
IFNA7
ECgene alternative splicing isoforms for
IFNA7

Expression for IFNA7 Gene

mRNA expression in normal human tissues for IFNA7 Gene

SOURCE GeneReport for Unigene cluster for IFNA7 Gene Hs.282274

genes like me logo Genes that share expression patterns with IFNA7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFNA7 Gene

Orthologs for IFNA7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA7 35
  • 98.06 (n)
  • 95.77 (a)
-- 36
  • 93 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 61 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
IFNAA 36
  • 60 (a)
ManyToMany
IFNAG 36
  • 61 (a)
ManyToMany
IFNAG 36
  • 62 (a)
ManyToMany
IFNAH 36
  • 62 (a)
ManyToMany
INFAF 36
  • 60 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 36
  • 62 (a)
ManyToMany
Gm13280 36
  • 60 (a)
ManyToMany
Ifna1 36
  • 61 (a)
ManyToMany
Ifna11 36
  • 57 (a)
ManyToMany
Ifna12 36
  • 61 (a)
ManyToMany
Ifna13 36
  • 61 (a)
ManyToMany
Ifna14 36
  • 58 (a)
ManyToMany
Ifna2 36
  • 58 (a)
ManyToMany
Ifna4 36
  • 55 (a)
ManyToMany
Ifna5 36
  • 61 (a)
ManyToMany
Ifna6 36
  • 61 (a)
ManyToMany
Ifna7 36
  • 59 (a)
ManyToMany
Ifna9 36
  • 59 (a)
ManyToMany
Ifnab 36
  • 59 (a)
ManyToMany
Species with no ortholog for IFNA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA7 Gene

ENSEMBL:
Gene Tree for IFNA7 (if available)
TreeFam:
Gene Tree for IFNA7 (if available)

Paralogs for IFNA7 Gene

(18) SIMAP similar genes for IFNA7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFNA7 Gene

genes like me logo Genes that share paralogs with IFNA7: view

Variants for IFNA7 Gene

Sequence variations from dbSNP and Humsavar for IFNA7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs113196039 -- 21,202,215(+) GAACC(A/G/T)TGGCC upstream-variant-2KB
rs116121955 -- 21,203,759(+) GACAA(G/T)GACAA upstream-variant-2KB
rs116368915 -- 21,204,039(+) TAGGA(A/T)TCAGA upstream-variant-2KB
rs191890750 -- 21,202,876(+) GCCAA(A/C)ACTTT upstream-variant-2KB
rs191931711 -- 21,202,305(+) GTTTT(A/G)CTTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNA7 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294
esv2738274 CNV Deletion 23290073
dgv1305e201 CNV Deletion 23290073
nsv516132 CNV Loss 19592680
nsv8425 CNV Gain+Loss 18304495
esv6326 CNV Loss 19470904
esv2738277 CNV Deletion 23290073

Variation tolerance for IFNA7 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IFNA7 Gene

Disorders for IFNA7 Gene

Relevant External Links for IFNA7

Genetic Association Database (GAD)
IFNA7
Human Genome Epidemiology (HuGE) Navigator
IFNA7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA7

No disorders were found for IFNA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA7 Gene

Publications for IFNA7 Gene

  1. Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (PMID: 8910771) Hussain M. … Liao M.-J. (J. Interferon Cytokine Res. 1996) 3 4 23 67
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  3. HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms. (PMID: 25972534) Reszka-Blanco N.J. … Su L. (J. Virol. 2015) 3
  4. Evidence for a different susceptibility of primate lentiviruses to type I interferons. (PMID: 23255800) Cordeil S. … Cimarelli A. (J. Virol. 2013) 3
  5. Role of retroviral restriction factors in the interferon-I+-mediated suppression of HIV-1 in vivo. (PMID: 22315404) Pillai S.K. … Wong J.K. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3

Products for IFNA7 Gene

Sources for IFNA7 Gene

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