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IFNA7 Gene

protein-coding   GIFtS: 47

GC09M021191
interferon, alpha 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
IFN-alpha-J1 3
IFNA-J 1, 2
OTTHUMP00000021136 2
Descriptions
IFN-alpha 7 2
Interferon alpha-J 3
Interferon alpha-J1 3
LeIF J 3
interferon, alpha 7 2
External Ids
HGNC: 54281
Entrez Gene: 34442
UniProtKB: P015673
Ensembl: ENSG000002140427
Search outside databases for aliases for IFNA7 gene

Previous GC identifers: GC09M021529 GC09M021402

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the
production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFNA7 gene  

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021191:     (about GC identifiers)

Start:
21,191,468 bp from pter
End:
21,192,204 bp from pter
Size:
737 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000009.10  NT_008413.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567 (See protein sequence)
Recommended Name: Interferon alpha-7 precursor  
Size: 189 amino acids; 22107 Da
Subcellular location: Secreted
Secondary accessions: Q14607

REFSEQ proteins: NP_066401.2  

ENSEMBL proteins: 
ENSP00000239347 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
R&D Systems Recombinant & Natural Proteins for IFNA7 (IFN-alpha J1)
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (IFNA7)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region TAS2995168
GO:0005615 extracellular space IEA--
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Antibodies for IFNA7: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (IFNA7), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for IFNA7

Assays for IFNA7: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro domains/families:
 IPR012351 4_helix_cytokine_core
 IPR015589 Interferon_alpha
 IPR000471 IInterferon_alpha/beta/delta


   GeneDecks  IFNA7 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P01567

ProtoNet protein and cluster: P01567

1 Blocks protein family: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567
Similarity: Belongs to the alpha/beta interferon family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021057

              Applied Biosystems Silencer® siRNAs for IFNA7

              Browse siRNA at Sigma-Aldrich  
                     Sigma-Aldrich shRNA Panels and shRNA for IFNA7  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021057
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021057
                                 untagged cDNA clone in CMV expression vector: NM_021057 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_021057

UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the
production of two enzymes: a protein kinase and an oligoadenylate synthetase

Genatlas biochemistry entry for IFNA7:
interferon type I,alpha 7,leukocyte

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005125 cytokine activity IEA--
GO:0005132 interferon-alpha/beta receptor binding TAS2995168
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Millipore Pathways for IFNA7
 Immune response IFN alpha/beta signaling pathway
  TICAM1-specific signaling pathways

   GeneDecks  IFNA7 for the pathways selected above  
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for  IFNA7  (Your Favorite Gene powered by Ingenuity) 
 IL-12 Signaling and Production in Macrophages
 Role of RIG1-like Receptors in Antiviral Innate Immunity
 Role of Cytokines in Mediating Communication between Immune Cells
 Activation of IRF by Cytosolic Pattern Recognition Receptors

   GeneDecks  IFNA7 for the pathways selected above  
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5/7 Kegg Pathways  (Kegg details for IFNA7) (see all 7 ):
 hsa04060 Cytokine-cytokine receptor interaction
 hsa04140 Regulation of autophagy
 hsa04612 Antigen processing and presentation
 hsa04620 Toll-like receptor signaling pathway
 hsa04630 Jak-STAT signaling pathway

   GeneDecks  IFNA7 for the pathways selected above  
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3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006952 defense response IEA--
GO:0007267 cell-cell signaling TAS2995168
GO:0009615 response to virus TAS2995168
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFNA7

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021057

              Browse siRNA at Sigma-Aldrich  
                     Sigma-Aldrich shRNA Panels and shRNA for IFNA7  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_021057  

REFSEQ mRNAs for IFNA7 gene: 

NM_021057.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_021057  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021057
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021057
                                 untagged cDNA clone in CMV expression vector: NM_021057 

Additional cDNA sequence: 

BC074991.2 BC074992.2 BC113994.1 BC114000.1 M34913.1 

1 DOTS entry:

DT.109612 

4 AceView cDNA sequences:

BC074991 BC074992 NM_021057 M34913 

highest scoring ESTs for IFNA7:

BC074991 BC074992 BC113994 BC114000 M34913 NM_021057 

Unigene Cluster for IFNA7:

Interferon, alpha 7
Hs.282274
Unigene Representative Sequence: M34913


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000239347  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IFNA7 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IFNA7

1 / 2 / 3

2 probe-sets matching IFNA7 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

208259_x_at2, 3 U133-A 13 1.00 0.29 -- -- NM_021057 0.40 0.67 0.55 1

208259_x_at2 U133Plus2 13 1.00 0.29 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.282274
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for IFNA7 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
IFNA71   -- interferon, alpha 7 98.06(n)
95.77(a)
741747  XM_001151819.1  XP_001151819.1 
About this table        Species with no ortholog for IFNA7

ENSEMBL Gene Tree for IFNA7
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for IFNA7 gene
IFNA12  IFNA212  IFNA22  IFNA172  IFNA62  IFNA42  IFNA142  IFNA132  
IFNA162  IFNA102  IFNA82  IFNA52  

Pseudogenes
1 related pseudogene


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/18 NCBI SNPs in IFNA7 are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 5)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs107571991,2
A,C,F,H21192356(+) TTAAAG/TACGTT 1 -- ng314Minor allele frequency- T:0.33EU EA WA 408
--
rs70462081,2
A,C21192408(+) tcaaaA/Gccttt 1 -- ng310--------
--
rs108115021,2
A,C21193008(+) ATCAAA/TCATAA 1 -- ng310--------
--
rs70459801,2
A,C21192410(+) aaagcA/Ctttta 1 -- ng310--------
rs70192301,2
F,H21193153(+) tgtaaC/Tgttga 1 -- ng314Minor allele frequency- T:0.01EU EA WA 418
--
rs107571981,2
A,C21192335(+) TTATGC/TACTCT 1 -- ng310--------
--
rs123794871,2
H21193973(+) AAATAG/CCCTGG 1 -- ng314Minor allele frequency- C:0.00EU EA WA 418
--
rs625589871,2
--21191840(+) AGTGGA/TAAATT 1 S/T mis10--------
--
rs349080231,2
--21192674(+) GTTTC-/CAAATT 1 -- ng310--------
--
rs359736011,2
--21192059(+) GCCCT-/ACCTAT 1 R/S fra10--------
About this table

HapMap Linkage Disequilibrium images for IFNA7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147567

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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10/33 PubMed articles for IFNA7 gene (see all 33 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3444 HGNC: 5428 AceView: IFNA7 Ensembl:ENSG00000214042 euGenes: HUgn3444
ECgene: IFNA7 H-InvDB: IFNA7
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for IFNA7:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IFNA7-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Browse siRNAs at Sigma-Aldrich Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for IFNA7 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search OriGene for IFNA7
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for IFNA7

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