V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

IFNA7 Gene

protein-coding GIFtS: 47

GC09M021191

interferon, alpha 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
IFN-alpha-J1 ^³
IFNA-J ^¹, ²
OTTHUMP00000021136 ^²

Descriptions
IFN-alpha 7 ^²
Interferon alpha-J ^³
Interferon alpha-J1 ^³
LeIF J ^³
interferon, alpha 7 ^²

External Ids
HGNC: 5428¹
Entrez Gene: 3444²
UniProtKB: P01567³
Ensembl: ENSG00000214042⁷

Search outside databases for aliases for IFNA7 gene

Previous GC identifers: GC09M021529 GC09M021402

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the

production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IFNA7 gene

Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22

IFNA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M021191: (about GC identifiers)

Start:	21,191,468 bp from pter
End:	21,192,204 bp from pter
Size:	737 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567 (See protein sequence)

Recommended Name: Interferon alpha-7 precursor

Size: 189 amino acids; 22107 Da

Subcellular location: Secreted

Secondary accessions: Q14607

REFSEQ proteins: NP_066401.2

ENSEMBL proteins:

ENSP00000239347

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IFNA7 (IFN-alpha J1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IFNA7)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	2995168
GO:0005615	extracellular space	IEA	--

About this table

Antibodies for IFNA7:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IFNA7), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for IFNA7

Assays for IFNA7:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01567

ProtoNet protein and cluster: P01567

1 Blocks protein family: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567

Similarity: Belongs to the alpha/beta interferon family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021057

Applied Biosystems Silencer® siRNAs for IFNA7

Browse siRNA at Sigma-Aldrich

Sigma-Aldrich shRNA Panels and shRNA for IFNA7

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_021057
Myc/DDK tagged cDNA clone in CMV expression vector: NM_021057
untagged cDNA clone in CMV expression vector: NM_021057

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021057

UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the

production of two enzymes: a protein kinase and an oligoadenylate synthetase

Genatlas biochemistry entry for IFNA7:

interferon type I,alpha 7,leukocyte

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005132	interferon-alpha/beta receptor binding	TAS	2995168

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for IFNA7 (Your Favorite Gene powered by Ingenuity)

IL-12 Signaling and Production in Macrophages
Role of RIG1-like Receptors in Antiviral Innate Immunity
Role of Cytokines in Mediating Communication between Immune Cells
Activation of IRF by Cytosolic Pattern Recognition Receptors

GeneDecks IFNA7 for the pathways selected above

About GeneDecksing

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006952	defense response	IEA	--
GO:0007267	cell-cell signaling	TAS	2995168
GO:0009615	response to virus	TAS	2995168

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFNA7

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021057

Browse siRNA at Sigma-Aldrich

Sigma-Aldrich shRNA Panels and shRNA for IFNA7

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021057

REFSEQ mRNAs for IFNA7 gene:

NM_021057.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021057

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021057
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021057
                                 untagged cDNA clone in CMV expression vector: NM_021057

Additional cDNA sequence:

BC074991.2 BC074992.2 BC113994.1 BC114000.1 M34913.1

1 DOTS entry:

DT.109612

4 AceView cDNA sequences:

BC074991 BC074992 NM_021057 M34913

highest scoring ESTs for IFNA7:

BC074991 BC074992 BC113994 BC114000 M34913 NM_021057

Unigene Cluster for IFNA7:

Interferon, alpha 7

Hs.282274

Unigene Representative Sequence: M34913

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000239347

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFNA7 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFNA7

¹ / ² / ³

2 probe-sets matching IFNA7 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
208259_x_at²^{, 3}	U133-A	13	1.00	0.29	--	--	NM_021057	0.40	0.67	0.55	1
208259_x_at²	U133Plus2	13	1.00	0.29	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.282274

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IFNA7 gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	IFNA7¹	--	interferon, alpha 7	98.06(n) 95.77(a)	741747 XM_001151819.1 XP_001151819.1

About this table Species with no ortholog for IFNA7

ENSEMBL Gene Tree for IFNA7

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IFNA7 gene

IFNA1² IFNA21² IFNA2² IFNA17² IFNA6² IFNA4² IFNA14² IFNA13²

IFNA16² IFNA10² IFNA8² IFNA5²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/18 NCBI SNPs in IFNA7 are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 5)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs10757199^1,2	A,C,F,H	21192356(+)	`TTAAAG/TACGTT`	1	--	ng3¹		4		EU EA WA	408
--	rs7046208^1,2	A,C	21192408(+)	`tcaaaA/Gccttt`	1	--	ng3¹		0	--	--	--	--
--	rs10811502^1,2	A,C	21193008(+)	`ATCAAA/TCATAA`	1	--	ng3¹		0	--	--	--	--
--	rs7045980^1,2	A,C	21192410(+)	`aaagcA/Ctttta`	1	--	ng3¹		0	--	--	--	--
	rs7019230^1,2	F,H	21193153(+)	`tgtaaC/Tgttga`	1	--	ng3¹		4		EU EA WA	418
--	rs10757198^1,2	A,C	21192335(+)	`TTATGC/TACTCT`	1	--	ng3¹		0	--	--	--	--
--	rs12379487^1,2	H	21193973(+)	`AAATAG/CCCTGG`	1	--	ng3¹		4		EU EA WA	418
--	rs62558987^1,2	--	21191840(+)	`AGTGGA/TAAATT`	1	S/T	mis¹		0	--	--	--	--
--	rs34908023^1,2	--	21192674(+)	`GTTTC-/CAAATT`	1	--	ng3¹		0	--	--	--	--
--	rs35973601^1,2	--	21192059(+)	`GCCCT-/ACCTAT`	1	R/S	fra¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for IFNA7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147567

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/33 PubMed articles for IFNA7 gene (see all 33 ):

Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (PubMed id 8910771)^{1, 3, 4} Hussain M.... Liao M.-J. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)^{3, 4} Nyman T.A.... Kalkkinen N. (1998)
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)^{2, 3} Olopade O.I....Diaz M.O. (1992)
Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)^{3, 4} Henco K.... Weissmann C. (1985)
Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells. (PubMed id 2995168)^{3, 4} Cohen S....Shafferman A. (1985)
Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster. (PubMed id 6181262)^{3, 4} Ullrich A.... Dull T.J. (1982)
Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity. (PubMed id 16418394)³ Peng G....Wahl S.M. (2006)
Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells. (PubMed id 16160188)³ Del Corno M....Gessani S. (2005)
HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration. (PubMed id 16278001)³ Schmidt B....Levy J.A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3444	HGNC: 5428	AceView: IFNA7	Ensembl:ENSG00000214042	euGenes: HUgn3444
ECgene: IFNA7	H-InvDB: IFNA7

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IFNA7
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IFNA7:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFNA7-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Browse siRNAs at Sigma-Aldrich		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IFNA7		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (IFNA7)
	Antibodies (IFNA7)

Search OriGene for IFNA7

Search Tocris compounds for IFNA7

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for IFNA7

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IFNA7 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

IFNA7 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for IFNA7

Summaries
for IFNA7

Genomic Location
for IFNA7

Proteins
for IFNA7

Protein Domains/
Families
for IFNA7

Gene Function
for IFNA7

Pathways & Interactions
for IFNA7

Drugs & Compounds
for IFNA7

Transcripts
for IFNA7

Expression
for IFNA7

Orthologs
for IFNA7

Paralogs
for IFNA7

SNPs/Variants
for IFNA7

Disorders & Mutations
for IFNA7

Medical News
for IFNA7

Publications
for IFNA7

Search for IFNA7

Genome Databases showing IFNA7

Other Databases showing IFNA7

Specialized Databases showing IFNA7

Licensable Technologies
for IFNA7

Services
for IFNA7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFNA7 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor IFNA7

Summariesfor IFNA7

Genomic Locationfor IFNA7

Proteinsfor IFNA7

Protein Domains/Familiesfor IFNA7

Gene Functionfor IFNA7

Pathways & Interactionsfor IFNA7

Drugs & Compoundsfor IFNA7

Transcriptsfor IFNA7

Expression for IFNA7

Orthologsfor IFNA7

Paralogsfor IFNA7

SNPs/Variantsfor IFNA7

Disorders & Mutationsfor IFNA7

Medical Newsfor IFNA7

Publicationsfor IFNA7

Search for IFNA7

Genome Databases showing IFNA7

Other Databases showing IFNA7

Specialized Databases showing IFNA7

Licensable Technologiesfor IFNA7

Servicesfor IFNA7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFNA7

Summaries
for IFNA7

Genomic Location
for IFNA7

Proteins
for IFNA7

Protein Domains/
Families
for IFNA7

Gene Function
for IFNA7

Pathways & Interactions
for IFNA7

Drugs & Compounds
for IFNA7

Transcripts
for IFNA7

Expression
for IFNA7

Orthologs
for IFNA7

Paralogs
for IFNA7

SNPs/Variants
for IFNA7

Disorders & Mutations
for IFNA7

Medical News
for IFNA7

Publications
for IFNA7

Licensable Technologies
for IFNA7

Services
for IFNA7