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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNA7 Gene

protein-coding   GIFtS: 55
GCID: GC09M021247

Interferon, Alpha 7

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Alpha 71 2     IFN-alpha-J12 3
Interferon Alpha-J2 3     IFN-alphaJ2
Interferon Alpha-J12 3     IFNA-J2
LeIF J2 3     IFN-Alpha 72
IFN-alpha-72 3     Interferon Alpha-72

External Ids:    HGNC: 54281   Entrez Gene: 34442   Ensembl: ENSG000002140427   OMIM: 1475675   UniProtKB: P015673   

Export aliases for IFNA7 gene to outside databases

Previous GC identifers: GC09M021529 GC09M021402 GC09M021191 GC09M021214 GC09M021224 GC09M021164 GC09M021228 GC09M021234 GC09M021237 GC09M021241 GC09M021244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFNA7 Gene: 
IFNA7 (interferon, alpha 7) is a protein-coding gene. Diseases associated with IFNA7 include acute hemorrhagic conjunctivitis, and conjunctivitis, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include interferon-alpha/beta receptor binding and cytokine activity. An important paralog of this gene is IFNA2.

UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFNA7 gene promoter:
         Egr-3   Egr-2   IRF-7A   Egr-4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IFNA7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021247:  view genomic region     (about GC identifiers)

Start:
21,201,468 bp from pter      End:
21,202,204 bp from pter
Size:
737 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567 (See protein sequence)
Recommended Name: Interferon alpha-7 precursor  
Size: 189 amino acids; 22107 Da
Subcellular location: Secreted
Secondary accessions: Q14607 Q5VV14

Explore the universe of human proteins at neXtProt for IFNA7: NX_P01567

Explore proteomics data for IFNA7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01567

  • IFNA7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IFNA7 Protein Expression
    REFSEQ proteins: NP_066401.2  
    ENSEMBL proteins: 
     ENSP00000239347  
    Reactome Protein details: P01567
    Human Recombinant Protein Products for IFNA7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IFNA7 (IFN-alpha J1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IFNA7
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IFNA7
    GenScript Custom Purified and Recombinant Proteins Services for IFNA7
    Novus Biologicals IFNA7 Protein
    Novus Biologicals IFNA7 Lysate
    Sino Biological Recombinant Protein for IFNA7
    Sino Biological Cell Lysate for IFNA7 
    ProSpec Recombinant Protein for IFNA7
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    IFNA7 for ontologies           About GeneDecksing



    IFNA7 Antibody Products: 
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    Novus Biologicals IFNA7 Antibody
    Abcam antibodies for IFNA7
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for IFNA7
    LSBio Antibodies in human, mouse, rat for IFNA7 

    Assay Products for IFNA7: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IFNA7
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFN: Interferons

    4 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR015589 Interferon_alpha
     IPR000471 Interferon_alpha/beta/delta
     IPR009079 4_helix_cytokine-like_core

    Graphical View of Domain Structure for InterPro Entry P01567

    ProtoNet protein and cluster: P01567

    1 Blocks protein domain: IPB000471 Interferon alpha

    UniProtKB/Swiss-Prot: IFNA7_HUMAN, P01567
    Similarity: Belongs to the alpha/beta interferon family


    IFNA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFNA7_HUMAN, P01567
    Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
    two enzymes: a protein kinase and an oligoadenylate synthetase

         Genatlas biochemistry entry for IFNA7:
    interferon type I,alpha 7,leukocyte

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding ----
    GO:0005132interferon-alpha/beta receptor binding TAS2995168
         
    IFNA7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IFNA7:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNA7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNA7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNA7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNA7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA7
    1 QIAGEN miScript miRNA Assays for microRNA that regulate IFNA7:
    hsa-miR-924
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFNA7
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of IFNA7

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IFNA7 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNA7 (NM_021057)
    Sino Biological Human cDNA Clone for IFNA7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA7
    Sirion Biotech Customized lentivirus for stable overexpression of IFNA7 
                         Customized lentivirus expression plasmids for stable overexpression of IFNA7 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IFNA7 About   (see all 24)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    Toll-like receptor signaling pathway0.93
    2Immune response IFN alpha/beta signaling pathway
    Immune response IFN alpha/beta signaling pathway0.71
    Interferon alpha/beta signaling0.45
    Regulation of IFNA signaling0.71
    3Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    RIG-I-like receptor signaling pathway0.52
    5Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for IFNA7
        Immune response IFN alpha/beta signaling pathway
    Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

    2 R&D Systems Pathways for IFNA7
        NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA7
        Cytokine Network
    Interferon Pathway
    JAK-STAT Pathway
    all-trans-Retinoic Acid Mediated Apoptosis

    2 GeneGo (Thomson Reuters) Pathways for IFNA7
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response IFN alpha/beta signaling pathway

    1 BioSystems Pathway for IFNA7
        Toll-like receptor signaling pathway


    5/10        Reactome Pathways for IFNA7 (see all 10)
        Hemostasis
    Regulation of IFNA signaling
    Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways


    5/15         Kegg Pathways  (Kegg details for IFNA7) (see all 15):
        Cytokine-cytokine receptor interaction
    Regulation of autophagy
    PI3K-Akt signaling pathway
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway


    IFNA7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA7

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for IFNA7 (ENSP000002393474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFNAR1ENSP000002701394STRING: ENSP00000270139
    IFNAR2ENSP000003439574STRING: ENSP00000343957
    IFNGR1ENSP000003567134STRING: ENSP00000356713
    IFNGR2ENSP000002902194STRING: ENSP00000290219
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response ----
    GO:0007267cell-cell signaling TAS2995168
    GO:0007596blood coagulation TAS--
    GO:0009615response to virus TAS2995168
    GO:0019221cytokine-mediated signaling pathway TAS--

    IFNA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IFNA7

    Search CenterWatch for drugs/clinical trials and news about IFNA7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IFNA7 gene: 
    NM_021057.2  

    Unigene Cluster for IFNA7:

    Interferon, alpha 7
    Hs.282274
    Unigene Representative Sequence: M34913
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000239347(uc003zop.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA7
    1 QIAGEN miScript miRNA Assays for microRNA that regulate IFNA7:
    hsa-miR-924
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IFNA7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA7
    Clone
    Products:
         
    OriGene clones in human, mouse for IFNA7 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNA7 (NM_021057)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA7
    Sirion Biotech Customized lentivirus for stable overexpression of IFNA7 
                         Customized lentivirus expression plasmids for stable overexpression of IFNA7 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNA7
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFNA7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA7

    Additional mRNA sequence: 

    BC074991.2 BC074992.2 BC113994.1 BC114000.1 M34913.1 

    1 DOTS entry:

    DT.109612 

    4 AceView cDNA sequences:

    BC074992 BC074991 NM_021057 M34913 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IFNA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IFNA7 Expression
    About this image


    See IFNA7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IFNA7

    SOURCE GeneReport for Unigene cluster: Hs.282274
        SABiosciences Expression via Pathway-Focused PCR Array including IFNA7: 
              Interferons & Receptors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for IFNA7 (if available)
    TreeFam Gene Tree for IFNA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IFNA7 gene
    IFNA22  IFNA42  IFNE2  IFNA142  IFNA52  IFNK2  IFNA12  IFNA212  
    IFNA172  IFNA62  IFNB12  IFNA132  IFNW12  IFNA162  IFNA102  IFNA82  
    18 SIMAP similar genes for IFNA7 using alignment to 1 protein entry:     IFNA7_HUMAN:
    IFNA10    IFNA17    IFNA4    IFNA21    IFNA14    IFNA16
    IFNA5    IFNA    IFNA2    IFNA2B    IFNA1    IFNA13
    IFNA6    IFNA8    IFN-2    IFNW1    IFNE    IFNB1

    IFNA7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IFNA7
    PGOHUM00000235992 PGOHUM00000236406


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/129 SNPs in IFNA7 are shown (see all 129)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845185001,2
    --21200975(+) AACCGA/GTATTA 1 -- ds50010--------
    rs1117106641,2
    C,F--21201087(+) CAACAG/TATAAC 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1510154711,2
    C--21201212(+) AAAAT-/AAAC  
            
    AAACA
    1 -- ds50010--------
    rs1877554901,2
    --21201213(+) AAATAA/GACAAA 1 -- ds50010--------
    rs1932965711,2
    --21201235(+) TTGTAC/TAGTAA 1 -- ds50010--------
    rs2012552291,2
    C--21201256(+) AAAAA-/GGAAAT 1 -- ds50010--------
    rs745602081,2
    C--21201310(+) CACAAT/CGTAAA 1 -- ds50013Minor allele frequency- C:0.09CSA WA EA 239
    rs1851139391,2
    --21201361(+) AAATAA/GTTAAA 1 -- ds50010--------
    rs1903585781,2
    --21201536(+) GAACTC/GATGAA 1 -- ut310--------
    rs1125389771,2
    C,F--21201621(+) TTTTTT/GCAAGT 2 /K /Q mis12Minor allele frequency- G:0.00CSA NA 4520

    HapMap Linkage Disequilibrium report for IFNA7 (21201468 - 21202204 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for IFNA7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738274CNV Deletion23290073
    dgv1305e201CNV Deletion23290073
    esv2738277CNV Deletion23290073
    nsv516132CNV Loss19592680
    nsv892735CNV Loss21882294
    esv6326CNV Loss19470904
    nsv892724CNV Gain21882294
    nsv892734CNV Gain21882294
    nsv8425CNV Gain+Loss18304495

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNA7
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNA7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147567    OMIM disorders: --

    11 diseases for IFNA7:    About MalaCards
    acute hemorrhagic conjunctivitis    conjunctivitis    measles    hiv/aids
    autoimmune thyroiditis    hepatitis c    influenza    hepatitis b
    hepatitis    thyroiditis    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for IFNA7:
    Acute hemorrhagic conjunctivitis

    IFNA7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IFNA7
    Human Genome Epidemiology (HuGE) Navigator: IFNA7 (3 documents)

    Export disorders for IFNA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IFNA7 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with IFNA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (PubMed id 8910771)1, 2, 9 Hussain M.... Liao M.-J. (1996)
    2. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (1998)
    5. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
    6. Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)1, 2 Henco K.... Weissmann C. (1985)
    7. Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells. (PubMed id 2995168)1, 2 Cohen S....Shafferman A. (1985)
    8. Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster. (PubMed id 6181262)1, 2 Ullrich A.... Dull T.J. (1982)
    9. Inhibitory effects of human immunodeficiency virus gp1 20 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cel ls. (PubMed id 22814248)1 Fang M....Yao H. (2012)
    10. HIV-1 Gag-virus-like particles inhibit HIV-1 replicati on in dendritic cells and T cells through IFN-a-dependent upregulation of APOBEC 3G and 3F. (PubMed id 22739040)1 Chang M.O....Takaku H. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3444 HGNC: 5428 AceView: IFNA7 Ensembl:ENSG00000214042 euGenes: HUgn3444
    ECgene: IFNA7 Kegg: 3444 H-InvDB: IFNA7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IFNA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IFNA7 gene:
    Search GeneIP for patents involving IFNA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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