Aliases for IFNA6 Gene
Aliases for IFNA6 Gene
External Ids for IFNA6 Gene
- HGNC: 5427
- Entrez Gene: 3443
- Ensembl: ENSG00000120235
- OMIM: 147566
- UniProtKB: P05013
Previous GeneCards Identifiers for IFNA6 Gene
- GC09M021677
- GC09M021551
Summaries for IFNA6 Gene
GeneCards Summary for IFNA6 Gene
IFNA6 (Interferon Alpha 6) is a Protein Coding gene. Diseases associated with IFNA6 include Extrinsic Cardiomyopathy. Among its related pathways are Cytokine Signaling in Immune system and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA5.
UniProtKB/Swiss-Prot for IFNA6 Gene
-
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA6 Gene
Genomics for IFNA6 Gene
GeneHancer (GH) Regulatory Elements for IFNA6 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09I021350 | Promoter | 0.5 | EPDnew | 550.8 | +0.4 | 402 | 0.1 | IFNA6 IFNA12P IFNA8 IFNWP2 KLHL9 | ||
GH09I021744 | Enhancer | 0.6 | FANTOM5 ENCODE | 7.1 | -393.7 | -393666 | 0.3 | MAX CEBPB EP300 | MTAP IFNA1 IFNA6 IFNA5 RN7SL151P | |
GH09I021653 | Enhancer | 0.3 | FANTOM5 | 11 | -302.2 | -302159 | 0.3 | MAFF | IFNA1 IFNA6 KLHL9 ENSG00000227443 KHSRPP1 | |
GH09I021016 | Enhancer | 0.3 | FANTOM5 | 9.1 | +334.6 | 334584 | 0 | IFNW1 IFNA1 IFNA6 IFNA5 HACD4 LOC105375989 SNORA30B | ||
GH09I021573 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 1.6 | -232.5 | -232537 | 20.1 | PKNOX1 SIN3A FEZF1 GTF3C2 ZNF121 FOS RUNX3 DEK REST TSHZ1 | FOCAD MIR31 IFNW1 IFNA1 IFNA6 MIR31HG ENSG00000227443 |
Regulatory Element Products
Genomic Locations for IFNA6 Gene
- chr9:21,349,835-21,351,378
- (GRCh38/hg38)
- Size:
- 1,544 bases
- Orientation:
- Minus strand
- chr9:21,349,834-21,351,377
- (GRCh37/hg19)
Genomic View for IFNA6 Gene
- Cytogenetic band:
-
- 9p21.3 by Ensembl
- 9p21.3 by Entrez Gene
- 9p21.3 by HGNC


RefSeq DNA sequence for IFNA6 Gene
Proteins for IFNA6 Gene
-
Protein details for IFNA6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05013-IFNA6_HUMAN
- Recommended name:
- Interferon alpha-6
- Protein Accession:
- P05013
- Q5VYQ1
Protein attributes for IFNA6 Gene
- Size:
- 189 amino acids
- Molecular mass:
- 22141 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for IFNA6 Gene
Other Protein References for IFNA6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for IFNA6
-
Abcam antibodies for IFNA6
- Invitrogen Antibodies for IFNA6
- GeneTex IFNA6 antibody for IFNA6
-
Santa Cruz Biotechnology (SCBT) Antibodies for IFNA6
Protein Products
-
OriGene Purified Proteins for IFNA6
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-
ProSci Proteins for IFNA6
-
Abcam proteins for IFNA6
Assay Products
No data available for DME Specific Peptides for IFNA6 Gene
Domains & Families for IFNA6 Gene
Gene Families for IFNA6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for IFNA6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IFNA6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P05013- Family:
-
- Belongs to the alpha/beta interferon family.
Function for IFNA6 Gene
Molecular function for IFNA6 Gene
- GENATLAS Biochemistry:
- interferon type I,alpha 6,leukocyte
- UniProtKB/Swiss-Prot Function:
- Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Phenotypes From GWAS Catalog for IFNA6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IEA,IBA | -- |
GO:0005126 | cytokine receptor binding | IEA | -- |
GO:0005132 | type I interferon receptor binding | IBA | -- |
Phenotypes for IFNA6 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for IFNA6 gene
-
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- Search ViGene Biosciences for IFNA6
CRISPR Products
-
OriGene CRISPR knockouts for IFNA6
- genomics-online: gRNA clones - Search results for 69 available IFNA6 gene related products
- Overview of 69 available IFNA6 gene related products
- Applied Biological Materials CRISPR for IFNA6
-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for IFNA6 Gene
- miRTarBase miRNAs that target IFNA6
miRNA Products
- Search ViGene Biosciences for IFNA6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IFNA6
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- genomics-online: shRNA clones - Search results for 69 available IFNA6 gene related products
- Overview of 69 available IFNA6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IFNA6 gene
Clone Products
- Sino Biological Human cDNA Clone for IFNA6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IFNA6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IFNA6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IFNA6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IFNA6
-
ViGene Biosciences adenoviral particle packaged cDNA for IFNA6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IFNA6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IFNA6 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFNA6 Gene
Localization for IFNA6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IFNA6 Gene
- Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | IEA,IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA6 Gene
Pathways & Interactions for IFNA6 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
2 | Immune response IFN alpha/beta signaling pathway |
.30
|
|
3 | Influenza A |
.34
.34
|
|
4 | Toll-like receptor signaling pathway | ||
5 | Kaposi's sarcoma-associated herpesvirus infection |
.33
|
Pathways by source for IFNA6 Gene
1 BioSystems pathway for IFNA6 Gene
10 Reactome pathways for IFNA6 Gene
19 KEGG pathways for IFNA6 Gene
2 GeneGo (Thomson Reuters) pathways for IFNA6 Gene
4 Qiagen pathways for IFNA6 Gene
Interacting Proteins for IFNA6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IBA | -- |
GO:0002286 | T cell activation involved in immune response | IBA | -- |
GO:0002323 | natural killer cell activation involved in immune response | IBA | -- |
GO:0006952 | defense response | IEA | -- |
GO:0006959 | humoral immune response | IBA | -- |
No data available for SIGNOR curated interactions for IFNA6 Gene
Transcripts for IFNA6 Gene
mRNA/cDNA for IFNA6 Gene
- (1) REFSEQ mRNAs :
- (6) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for IFNA6
- genomics-online: gRNA clones - Search results for 69 available IFNA6 gene related products
- Overview of 69 available IFNA6 gene related products
- Applied Biological Materials CRISPR for IFNA6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNA6
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miRNA Products
- Search ViGene Biosciences for IFNA6
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 69 available IFNA6 gene related products
- Overview of 69 available IFNA6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IFNA6 gene
Clone Products
- Sino Biological Human cDNA Clone for IFNA6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IFNA6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IFNA6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IFNA6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for IFNA6 Gene
mRNA differential expression in normal tissues according to GTEx for IFNA6 Gene
NURSA nuclear receptor signaling pathways regulating expression of IFNA6 Gene:
IFNA6SOURCE GeneReport for Unigene cluster for IFNA6 Gene:
Hs.533470Primer Products
-
OriGene qPCR primer pairs for IFNA6
- genomics-online: primer clones - Search results for 69 available IFNA6 gene related products
- Overview of 69 available IFNA6 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA6 Gene
Orthologs for IFNA6 Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | IFNA6 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | -- 34 |
|
ManyToMany | |
IFNAG 34 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
IFNAA 34 |
|
ManyToMany | |||
IFNAH 34 |
|
ManyToMany | |||
INFAF 34 |
|
ManyToMany | |||
mouse (Mus musculus) |
Mammalia | Gm12597 34 |
|
ManyToMany | |
Ifna13 34 |
|
ManyToMany | |||
Ifna6 34 |
|
ManyToMany | |||
Gm13280 34 |
|
ManyToMany | |||
Ifna12 34 |
|
ManyToMany | |||
Ifna5 34 |
|
ManyToMany | |||
Ifna1 34 |
|
ManyToMany | |||
Ifna9 34 |
|
ManyToMany | |||
Ifna14 34 |
|
ManyToMany | |||
Ifna7 34 |
|
ManyToMany | |||
Ifna2 34 |
|
ManyToMany | |||
Ifnab 34 |
|
ManyToMany | |||
Ifna11 34 |
|
ManyToMany | |||
Ifna4 34 |
|
ManyToMany |
- Species where no ortholog for IFNA6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for IFNA6 Gene
Paralogs for IFNA6 Gene
(18) SIMAP similar genes for IFNA6 Gene using alignment to 1 proteins:
Variants for IFNA6 Gene
SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000037362 | -- | 21,351,796(-) | G/A | upstream_transcript_variant | |
rs1000108674 | -- | 21,352,314(-) | C/T | upstream_transcript_variant | |
rs1001117880 | -- | 21,351,826(-) | C/T | upstream_transcript_variant | |
rs1003577261 | -- | 21,350,739(-) | A/C | coding_sequence_variant, missense_variant | |
rs1004587659 | -- | 21,352,067(-) | C/T | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2764150 | CNV | gain+loss | 21179565 |
nsv968602 | CNV | duplication | 23825009 |
Additional Variant Information for IFNA6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IFNA6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA6 Gene
Disorders for IFNA6 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
extrinsic cardiomyopathy |
|
|
Additional Disease Information for IFNA6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA6 Gene
Publications for IFNA6 Gene
- Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
- Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
- Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 44 58
- Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
- Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 44 58
Products for IFNA6 Gene
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- Invitrogen Antibodies for IFNA6
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IFNA6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 53 available IFNA6 Antibodies ranked by validation data
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- Overview of 69 available IFNA6 gene related products
Sources for IFNA6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
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