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IFNA6 Gene(Protein Coding)

Interferon Alpha 6

GCID:
GC09M021340
GIFtS:
43
Genes Participants
UDN Logo

Aliases for IFNA6 Gene

Aliases for IFNA6 Gene

  • Interferon Alpha 6 2 3 5
  • Interferon Alpha-54 3 4
  • Interferon Alpha-K 3 4
  • IFN-Alpha-6 3 4
  • LeIF K 3 4
  • Interferon, Alpha 6 2
  • Interferon Alpha-6 3
  • IFN-AlphaK 3

External Ids for IFNA6 Gene

Previous GeneCards Identifiers for IFNA6 Gene

  • GC09M021677
  • GC09M021551

Summaries for IFNA6 Gene

GeneCards Summary for IFNA6 Gene

IFNA6 (Interferon Alpha 6) is a Protein Coding gene. Diseases associated with IFNA6 include Extrinsic Cardiomyopathy. Among its related pathways are Cytokine Signaling in Immune system and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA5.

UniProtKB/Swiss-Prot for IFNA6 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA6 Gene

Additional gene information for IFNA6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA6 Gene

Genomics for IFNA6 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IFNA6 Gene

Promoters and enhancers for IFNA6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09I021350 Promoter 0.5 EPDnew 550.8 +0.4 402 0.1 IFNA6 IFNA12P IFNA8 IFNWP2 KLHL9
GH09I021744 Enhancer 0.6 FANTOM5 ENCODE 7.1 -393.7 -393666 0.3 MAX CEBPB EP300 MTAP IFNA1 IFNA6 IFNA5 RN7SL151P
GH09I021653 Enhancer 0.3 FANTOM5 11 -302.2 -302159 0.3 MAFF IFNA1 IFNA6 KLHL9 ENSG00000227443 KHSRPP1
GH09I021016 Enhancer 0.3 FANTOM5 9.1 +334.6 334584 0 IFNW1 IFNA1 IFNA6 IFNA5 HACD4 LOC105375989 SNORA30B
GH09I021573 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -232.5 -232537 20.1 PKNOX1 SIN3A FEZF1 GTF3C2 ZNF121 FOS RUNX3 DEK REST TSHZ1 FOCAD MIR31 IFNW1 IFNA1 IFNA6 MIR31HG ENSG00000227443
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFNA6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNA6 gene promoter:

Genomic Locations for IFNA6 Gene

Genomic Locations for IFNA6 Gene
chr9:21,349,835-21,351,378
(GRCh38/hg38)
Size:
1,544 bases
Orientation:
Minus strand
chr9:21,349,834-21,351,377
(GRCh37/hg19)

Genomic View for IFNA6 Gene

Genes around IFNA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IFNA6 Gene

Proteins for IFNA6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IFNA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05013-IFNA6_HUMAN
    Recommended name:
    Interferon alpha-6
    Protein Accession:
    P05013
    Secondary Accessions:
    • Q5VYQ1

    Protein attributes for IFNA6 Gene

    Size:
    189 amino acids
    Molecular mass:
    22141 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA6 Gene

Post-translational modifications for IFNA6 Gene

No Post-translational modifications

Other Protein References for IFNA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA6 Gene

Domains & Families for IFNA6 Gene

Gene Families for IFNA6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNA6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IFNA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05013

UniProtKB/Swiss-Prot:

IFNA6_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA6: view

Function for IFNA6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IFNA6 Gene

GENATLAS Biochemistry:
interferon type I,alpha 6,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Phenotypes From GWAS Catalog for IFNA6 Gene

Gene Ontology (GO) - Molecular Function for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA6: view
genes like me logo Genes that share phenotypes with IFNA6: view

Animal Model Products

miRNA for IFNA6 Gene

miRTarBase miRNAs that target IFNA6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFNA6 Gene

Localization for IFNA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA6 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with IFNA6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA6 Gene

Pathways & Interactions for IFNA6 Gene

genes like me logo Genes that share pathways with IFNA6: view

Gene Ontology (GO) - Biological Process for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA6: view

No data available for SIGNOR curated interactions for IFNA6 Gene

Drugs & Compounds for IFNA6 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IFNA6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IFNA6 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA6 Gene

No ASD Table

Relevant External Links for IFNA6 Gene

GeneLoc Exon Structure for
IFNA6
ECgene alternative splicing isoforms for
IFNA6

Expression for IFNA6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNA6 Gene

mRNA expression in normal human tissues for IFNA6 Gene
mRNA expression by BioGPS for IFNA6 GenemRNA expression by GTEx for IFNA6 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA6 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x6.2), Brain - Hippocampus (x4.5), and Brain - Amygdala (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of IFNA6 Gene:

IFNA6

SOURCE GeneReport for Unigene cluster for IFNA6 Gene:

Hs.533470
genes like me logo Genes that share expression patterns with IFNA6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA6 Gene

Orthologs for IFNA6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IFNA6 33 34
  • 99.12 (n)
cow
(Bos Taurus)
 Mammalia -- 34
  • 65 (a)
 ManyToMany
IFNAG 34 34
  • 65 (a)
 ManyToMany
-- 34
  • 64 (a)
 ManyToMany
-- 34
  • 64 (a)
 ManyToMany
-- 34
  • 63 (a)
 ManyToMany
-- 34
  • 63 (a)
 ManyToMany
IFNAA 34
  • 63 (a)
 ManyToMany
IFNAH 34
  • 62 (a)
 ManyToMany
INFAF 34
  • 62 (a)
 ManyToMany
mouse
(Mus musculus)
 Mammalia Gm12597 34
  • 61 (a)
 ManyToMany
Ifna13 34
  • 61 (a)
 ManyToMany
Ifna6 34
  • 61 (a)
 ManyToMany
Gm13280 34
  • 60 (a)
 ManyToMany
Ifna12 34
  • 60 (a)
 ManyToMany
Ifna5 34
  • 60 (a)
 ManyToMany
Ifna1 34
  • 59 (a)
 ManyToMany
Ifna9 34
  • 59 (a)
 ManyToMany
Ifna14 34
  • 58 (a)
 ManyToMany
Ifna7 34
  • 58 (a)
 ManyToMany
Ifna2 34
  • 57 (a)
 ManyToMany
Ifnab 34
  • 57 (a)
 ManyToMany
Ifna11 34
  • 56 (a)
 ManyToMany
Ifna4 34
  • 55 (a)
 ManyToMany
Species where no ortholog for IFNA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA6 Gene

ENSEMBL:
Gene Tree for IFNA6 (if available)
TreeFam:
Gene Tree for IFNA6 (if available)

Paralogs for IFNA6 Gene

Paralogs for IFNA6 Gene

(18) SIMAP similar genes for IFNA6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA6: view

Variants for IFNA6 Gene

Sequence variations from dbSNP and Humsavar for IFNA6 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000037362 -- 21,351,796(-) G/A upstream_transcript_variant
rs1000108674 -- 21,352,314(-) C/T upstream_transcript_variant
rs1001117880 -- 21,351,826(-) C/T upstream_transcript_variant
rs1003577261 -- 21,350,739(-) A/C coding_sequence_variant, missense_variant
rs1004587659 -- 21,352,067(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNA6 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
nsv968602 CNV duplication 23825009

Variation tolerance for IFNA6 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 10.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA6 Gene

Disorders for IFNA6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNA6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
extrinsic cardiomyopathy
- elite association - COSMIC cancer census association via MalaCards
Search IFNA6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNA6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFNA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA6 Gene

Publications for IFNA6 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  2. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
  3. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 44 58
  4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 44 58

Products for IFNA6 Gene

Sources for IFNA6 Gene

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