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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFNA6 Gene

protein-coding GIFtS: 56
GCID: GC09M021340

Interferon, Alpha 6

Microbiology & Infectious Diseases Congress

13 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Interferon, Alpha 6¹ ²		IFN-alpha-6² ³
Interferon Alpha-54² ³		IFN-alphaK²
Interferon Alpha-K² ³		Interferon Alpha-6²
LeIF K² ³

External Ids:	HGNC: 5427¹	Entrez Gene: 3443²	Ensembl: ENSG00000120235⁷	OMIM: 147566⁵	UniProtKB: P05013³

Export aliases for IFNA6 gene to outside databases

Previous GC identifers: GC09M021677 GC09M021551

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IFNA6 Gene:

IFNA6 (interferon, alpha 6) is a protein-coding gene. Diseases associated with IFNA6 include dengue hemorrhagic fever, and hemorrhagic fever, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include cytokine receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNA6_HUMAN, P05013

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two

enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA6 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.2 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFNA6 gene promoter:
HEN1 Egr-3 Egr-2 IRF-7A NF-kappaB1 NF-kappaB Egr-4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for IFNA6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22

IFNA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA6 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M021340: view genomic region (about GC identifiers)

Start:	21,349,834 bp from pter	End:	21,351,377 bp from pter
Size:	1,544 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFNA6_HUMAN, P05013 (See protein sequence)

Recommended Name: Interferon alpha-6 precursor

Size: 189 amino acids; 22141 Da

Subcellular location: Secreted

Secondary accessions: Q5VYQ1

Explore the universe of human proteins at neXtProt for IFNA6: NX_P05013

Explore proteomics data for IFNA6 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P05013

IFNA6 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_066282.1

ENSEMBL proteins:

ENSP00000369558

Reactome Protein details: P05013
Human Recombinant Protein Products for IFNA6:

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	Novus Biologicals IFNA6 Protein Novus Biologicals IFNA6 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

IFNA6 for ontologies About GeneDecksing

IFNA6 Antibody Products:

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	Novus Biologicals IFNA6 Antibodies
	Abcam antibodies for IFNA6
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	ThermoFisher Antibodies for IFNA6
	LSBio Antibodies in human, mouse, rat for IFNA6

Assay Products for IFNA6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for IFNA6
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IFNA6
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

IFN: Interferons

4 InterPro protein domains:

IPR012351 4_helix_cytokine_core

IPR015589 Interferon_alpha

IPR000471 Interferon_alpha/beta/delta

IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P05013

ProtoNet protein and cluster: P05013

1 Blocks protein domain: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNA6_HUMAN, P05013

Similarity: Belongs to the alpha/beta interferon family

IFNA6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IFNA6_HUMAN, P05013

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two

enzymes: a protein kinase and an oligoadenylate synthetase

Genatlas biochemistry entry for IFNA6:

interferon type I,alpha 6,leukocyte

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005126	cytokine receptor binding	NAS	--

IFNA6 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for IFNA6:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNA6

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNA6

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFNA6
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for IFNA6
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IFNA6
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for IFNA6 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNA6 (NM_021002)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IFNA6
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		Sirion Biotech Customized stable knockdown cell line services for IFNA6 Customized inducible knockdown cell line services for IFNA6 Customized stable overexpressing cell line services for IFNA6 Customized inducible overexpressing cell line services for IFNA6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IFNA6 About (see all 23)

See pathways by source

SuperPath

Contained pathways About

Toll-like receptor signaling pathway

	Toll-like receptor signaling pathway	0.93			Hepatitis B	0.31
	Toll-like receptor signaling pathway	0.93

Immune response IFN alpha/beta signaling pathway

	Immune response IFN alpha/beta signaling pathway	0.71			Interferon alpha/beta signaling	0.45
	Regulation of IFNA signaling	0.71

Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

0.91

Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways

0.91

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

0.52

RIG-I-like receptor signaling pathway

0.52

Influenza A

	Influenza A	0.34			Herpes simplex infection	0.33
	Measles	0.34

Pathways by source See SuperPaths
Show all pathways

2 EMD Millipore Pathways for IFNA6

	Immune response IFN alpha/beta signaling pathway
	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA6

	Cytokine Network
	Interferon Pathway
	JAK-STAT Pathway
	all-trans-Retinoic Acid Mediated Apoptosis

2 GeneGo (Thomson Reuters) Pathways for IFNA6

	Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
	Immune response IFN alpha/beta signaling pathway

1 BioSystems Pathway for IFNA6

Toll-like receptor signaling pathway

5/10 Reactome Pathways for IFNA6 (see all 10)

	Hemostasis
	Regulation of IFNA signaling
	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

5/15 Kegg Pathways (Kegg details for IFNA6) (see all 15):

	Cytokine-cytokine receptor interaction
	Regulation of autophagy
	PI3K-Akt signaling pathway
	Toll-like receptor signaling pathway
	RIG-I-like receptor signaling pathway

IFNA6 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IFNA6

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/26 Interacting proteins for IFNA6 (P05013³ ENSP00000369558⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GKAP1	Q5VSY0³	I2D: score=1
KLHL12	Q53G59³	I2D: score=1
MAGEA11	P43364³	I2D: score=1
PLSCR1	O15162³	I2D: score=1
IFNA14	ENSP00000369571⁴	STRING: ENSP00000369571

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006952	defense response	--	--
GO:0007596	blood coagulation	TAS	--
GO:0009615	response to virus	NAS	--
GO:0019221	cytokine-mediated signaling pathway	TAS	--
GO:0045087	innate immune response	TAS	--

IFNA6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNA6

Search CenterWatch for drugs/clinical trials and news about IFNA6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNA6 gene:

NM_021002.2

Unigene Cluster for IFNA6:

Interferon, alpha 6

Hs.533470

Unigene Representative Sequence: BC069471

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000380210(uc011lni.2)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IFNA6
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for IFNA6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA6
		Sirion Biotech Custom design and validation of potent shRNA sequences against IFNA6

Clone Products:		OriGene clones in human, mouse for IFNA6 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNA6 (NM_021002)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA6

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IFNA6
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat IFNA6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA6

Additional mRNA sequence:

BC069471.1 BC096697.1 BC096710.1 BC096730.1 BC098357.1

1 DOTS entry:

DT.91811057

6 AceView cDNA sequences:

BC074956 NM_002172 V00542 BC069471 CR541921 NM_021002

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNA6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGATCCTTCT

About this image

See IFNA6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA6

SOURCE GeneReport for Unigene cluster: Hs.533470

SABiosciences Expression via Pathway-Focused PCR Array including IFNA6:

Interferons & Receptors in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for IFNA6 (if available)
TreeFam Gene Tree for IFNA6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IFNA6 gene

IFNA7² IFNA2² IFNA4² IFNE² IFNA14² IFNA5² IFNK² IFNA1²

IFNA21² IFNA17² IFNB1² IFNA13² IFNW1² IFNA16² IFNA10² IFNA8²

18 SIMAP similar genes for IFNA6 using alignment to 1 protein entry: IFNA6_HUMAN:

IFNA14 IFNA5 IFN-2 IFNA IFNA10 IFNA4

IFNA17 IFNA21 IFNA2 IFNA1 IFNA13 IFNA2B

IFNA7 IFNA16 IFNA8 IFNW1 IFNE IFNB1

IFNA6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183862257^1,2		--	21349841(+)	`AACTTC/GAGTAT`	1	--	ds500¹		0	--	--	--	--
rs189366345^1,2		--	21349900(+)	`GAGAAC/TCGGCT`	1	--	ds500¹		0	--	--	--	--
rs28383779^1,2	C,F	--	21349986(-)	`TAGTCG/TATGTA`	1	--	ds500¹ ese³		1		NA	120
rs192534612^1,2		--	21349987(+)	`ACATCA/GACTAA`	1	--	ds500¹		0	--	--	--	--
rs184384196^1,2		--	21350017(+)	`TTATGG/TTATCA`	1	--	ds500¹		0	--	--	--	--
rs2990142^1,2	C,H	--	21350049(+)	`TATGCA/TTTTAT`	1	--	ds500¹ ese³		9		NA WA CSA EA	369
rs2990143^1,2	C,F,A	--	21350050(+)	`ATGCTT/CTTATA`	1	--	ds500¹ ese³		3		WA NA EA	358
rs2990144^1,2	C,F,A	--	21350078(+)	`ATTATA/TGTCAA`	1	--	ds500¹		6		WA CSA NA EA	366
rs16938352^1,2	C,F	--	21350168(+)	`CACGAT/CGTTGC`	1	--	ds500¹ ese³		5		NA CSA WA	262
rs12375790^1,2	C,H	--	21350174(+)	`GTTGCT/CTAACA`	1	--	ds500¹		4		NS EA	420
rs190195987^1,2		--	21350244(+)	`AGTCTA/TTAAAA`	1	--	ds500¹		0	--	--	--	--
rs201569487^1,2	C	--	21350283(+)	`TAGTCA/GTCAAT`	1	--	ds500¹		0	--	--	--	--
rs115050731^1,2	C,F	--	21350297(+)	`AGTCGT/ATTCTG`	1	--	ds500¹		1		WA	118
rs28383778^1,2	C,F,H	--	21350304(-)	`TCCAAC/AACAGA`	1	--	ds500¹ ese³		3		NS EU	1595
rs200866459^1,2	C	--	21350366(+)	`AGAAGC/GATCTC`	2	S C	mis¹		0	--	--	--	--
rs202179791^1,2	C	--	21350423(+)	`TCTCTG/TTCAGG`	2	K T	mis¹		0	--	--	--	--
rs61736258^1,2	C,F	--	21350487(+)	`CATCAG/AGGGAG`	2	/L	syn¹		4		NS CSA WA NA	4726
rs142796435^1,2	C	--	21350577(+)	`TAGAAA/GCCTCT`	2	L F	mis¹		0	--	--	--	--
rs147415542^1,2	C	--	21350595(+)	`AGCAAC/TAGATG`	2	I V	mis¹		0	--	--	--	--
rs76096785^1,2	C,F	--	21350603(+)	`ATGAGT/CCCTTT`	2	/D /G	mis¹		3		WA NA EU	5993
rs186416653^1,2	C	--	21350604(+)	`TGAGTC/TCTTTG`	2	N D	mis¹		0	--	--	--	--
rs2988573^1,2	C,F,A,H	--	21350620(+)	`AAGAGG/ATTGAA`	2	/N	syn¹ ese³		12		EA NA NS WA CSA EU	7797
rs189717919^1,2	C	--	21350627(+)	`TGAAGG/TTCTGC`	2	N T	mis¹		0	--	--	--	--
rs112773436^1,2	C,F	--	21350634(+)	`CTGCTG/AAATCA`	2	/Q /*	stg¹		2		CSA NA	4554
rs141284622^1,2	C	--	21350640(+)	`AATCAC/ACTCAT`	2	/V /L	mis¹		1		NA	4552
rs61736257^1,2	C,F	--	21350701(+)	`TCCTGG/AGGAAA`	2	/P	syn¹		3		NS NA EU	5933
rs201824804^1,2	C	--	21350709(+)	`AAATCT/CGAAGT`	2	/R /G	mis¹		1		EU	1317
rs200999463^1,2	C	--	21350710(+)	`AATCTG/AAAGTC`	2	/F	syn¹		1		EU	1317
rs61736255^1,2	C,F	--	21350731(+)	`TTCAGA/GCAGGA`	2	C	syn¹		3		NS NA EU	5943
rs61736254^1,2	C,F	--	21350741(+)	`AGAAAA/GGAGAG`	2	P L	mis¹		3		NS NA EU	5945
rs190705153^1,2		--	21350748(+)	`AGAGAC/TTCTCC`	2	I V	mis¹		0	--	--	--	--
rs114283047^1,2	C,F	--	21350803(+)	`TGGGTC/TTGAGG`	2	Q	syn¹		2		WA NA	4668
rs199909475^1,2		--	21350886(+)	`AGCCAC/TTGTAG`	2	M V	mis¹		0	--	--	--	--
rs138085325^1,2	C	--	21350904(+)	`AGATGC/TTGTTG`	1	--	us2k¹		0	--	--	--	--
rs10123853^1,2	C,F,H	--	21350910(+)	`TGTTGG/CACTTG`	1	--	us2k¹ ese³		7		NS EA CSA WA	543
rs181850780^1,2		--	21350937(+)	`TGAACC/TTTCAG`	1	--	us2k¹		0	--	--	--	--
rs187414422^1,2	C	--	21350942(+)	`CTTCAA/GCTCTA`	1	--	us2k¹		0	--	--	--	--
rs117181746^1,2	C,F	--	21351015(+)	`TCAGAA/GTTTAC`	1	--	us2k¹		1		EA	120
rs191750559^1,2		--	21351028(+)	`TCTACA/GTCTGA`	1	--	us2k¹		0	--	--	--	--
rs149536695^1,2		--	21351168(+)	`AGAAAC/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs183577776^1,2	C	--	21351221(+)	`ATATTA/G/TTATAT`	1	--	us2k¹		0	--	--	--	--
rs112972784^1,2	F	--	21351248(+)	`TGTATG/ATCTAC`	1	--	us2k¹		2		CSA	4
rs10124601^1,2	C,F,A,H	--	21351481(+)	`GACATG/ACATAA`	1	--	us2k¹		6		NS EA NA CSA	422
rs188138115^1,2		--	21351507(+)	`AAAATG/TAAATT`	1	--	us2k¹		0	--	--	--	--
rs10124647^1,2	C,A	--	21351611(+)	`ccagaG/Ttgtca`	1	--	us2k¹		0	--	--	--	--
rs182109500^1,2		--	21351649(+)	`TTAACC/TGTTGA`	1	--	us2k¹		0	--	--	--	--
rs186830539^1,2		--	21351650(+)	`TAACTA/GTTGAT`	1	--	us2k¹		0	--	--	--	--
rs10124651^1,2	C,F,H	--	21351656(+)	`ttgatG/Atgttg`	1	--	us2k¹		4		NS EA	420
rs143663439^1,2		--	21351826(+)	`TATTCA/GCCATA`	1	--	us2k¹		0	--	--	--	--
rs184897103^1,2		--	21351918(+)	`AATTCA/GATAAG`	1	--	us2k¹		0	--	--	--	--
rs12351654^1,2	H	--	21351938(+)	`cactaG/Aagaat`	1	--	us2k¹		4		NS EA	416
rs28697058^1,2	F	--	21351944(+)	`AGAATG/AAGATT`	1	--	us2k¹		1		CSA	2
rs193072517^1,2		--	21351956(+)	`TGTAAA/GAATTG`	1	--	us2k¹		0	--	--	--	--
rs185232370^1,2		--	21352075(+)	`TTTGAA/TAATAT`	1	--	us2k¹		0	--	--	--	--
rs146327067^1,2		--	21352084(+)	`ATCATC/GAATTT`	1	--	us2k¹		0	--	--	--	--
rs17334047^1,2	C,F	--	21352135(-)	`TAAATA/GTATGT`	1	--	us2k¹		3		CSA WA NA	240
rs28507568^1,2	F	--	21352156(+)	`ACCAAG/CTCAAT`	1	--	us2k¹		1		CSA	2
rs35101870^1,2	C,F	--	21352175(-)	`TTTCTC/TTTTGT`	1	--	us2k¹		2		WA NA	238
rs144392973^1,2		--	21352205(+)	`ATAACC/TGGATA`	1	--	us2k¹		0	--	--	--	--
rs113425651^1,2	C	--	21352244(+)	`AACTCG/CAATCC`	1	--	us2k¹		1		CSA	2
rs141073363^1,2	C	--	21352289(+)	`AAGTTC/GCCTCA`	1	--	us2k¹		0	--	--	--	--
rs189731991^1,2		--	21352301(+)	`ACCTAC/TAGATT`	1	--	us2k¹		0	--	--	--	--
rs9333356^1,2	C,F,H	--	21352377(-)	`GTCAAC/TAGAAC`	1	--	us2k¹		13		NS EA NA WA	1702
rs149854622^1,2		--	21352401(+)	`GTACCA/TGGCCT`	1	--	us2k¹		0	--	--	--	--
rs181209043^1,2		--	21352416(+)	`TACTTA/CTTCAA`	1	--	us2k¹		0	--	--	--	--
rs144875355^1,2	C	--	21352468(+)	`ATACTA/GGAAGG`	1	--	us2k¹		0	--	--	--	--
rs35353365^1,2	C,F	--	21352483(-)	`GGTCAC/TCCATG`	1	--	us2k¹		1		NA	120
rs183481443^1,2		--	21352526(+)	`TTAGGA/TTTATA`	1	--	us2k¹		0	--	--	--	--
rs188147177^1,2		--	21352572(+)	`TAAGTA/GTCAAT`	1	--	us2k¹		0	--	--	--	--
rs180948329^1,2		--	21352579(+)	`CAATAA/GTGATT`	1	--	us2k¹		0	--	--	--	--
rs72699197^1,2	C,F	--	21352636(+)	`ATATAC/TGGCAC`	1	--	us2k¹		2		WA NA	238
rs149027074^1,2		--	21352671(+)	`ATAATA/TTTCAG`	1	--	us2k¹		0	--	--	--	--
rs614541^1,2	C,F,O,A,H	--	21352862(+)	`TAGTAC/TCCCTG`	1	--	us2k¹		24		NS EA NA WA	2828
rs141102746^1,2	--	--	21350476(+)	`GAGTCC/TTCATT`	2	E	syn¹		1		NA	4552
rs368763578^1,2	--	--	21350197(+)	`CTTGAC/TCGTTT`	1	--	ds500¹		0	--	--	--	--
rs374477672^1,2	--	--	21352181(+)	`GAGAA-/CCATCT`	1	--	us2k¹		0	--	--	--	--
rs370554168^1,2	--	--	21351179(+)	`TCTTAA/TTTGAA`	1	--	us2k¹		0	--	--	--	--
rs373174690^1,2	--	--	21351293(+)	`TTTATG/TTTTCT`	1	--	us2k¹		0	--	--	--	--
rs373172024^1,2	--	--	21350123(+)	`CATCAG/TCTTAG`	1	--	ds500¹		0	--	--	--	--
rs370874088^1,2	--	--	21350343(+)	`TTCTTG/TCAAGT`	2	K Q	mis¹		0	--	--	--	--
rs377258038^1,2	--	--	21352116(+)	`TTAAAG/TTCAAA`	1	--	us2k¹		0	--	--	--	--
rs375649668^1,2	--	--	21350602(+)	`GATGAA/GTCCTT`	2	D	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IFNA6 (21349834 - 21351377 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for IFNA6: About this table

Variant ID	Type	Subtype	PubMed ID
nsv892724	CNV	Gain	21882294
nsv892736	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IFNA6 for disorders           About GeneDecksing

OMIM gene information: 147566    OMIM disorders: --

13 diseases for IFNA6:    About MalaCards

dengue hemorrhagic fever hemorrhagic fever measles hiv/aids

autoimmune thyroiditis bronchiolitis hepatitis c influenza

hepatitis b hepatitis thyroiditis melanoma

tuberculosis

Genetic Association Database (GAD): IFNA6
Human Genome Epidemiology (HuGE) Navigator: IFNA6 (7 documents)

Export disorders for IFNA6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFNA6 gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with IFNA6)

Utopia: connect your pdf to the dynamic
world of online information

Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)^{1, 4} Silva L.K....Teixeira M.G. (2010)
Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (2010)
Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)^{1, 4} Mosbruger T.L....Thio C.L. (2010)
Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843)^{1, 4} Yang X.R....Goldstein A.M. (2010)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (2009)
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (2007)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)^{1, 3} Olopade O.I....Diaz M.O. (1992)
Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)^{1, 2} Henco K.... Weissmann C. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3443	HGNC: 5427	AceView: IFNA14	Ensembl:ENSG00000120235	euGenes: HUgn3443
ECgene: IFNA6	Kegg: 3443	H-InvDB: IFNA6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFNA6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IFNA6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IFNA6 gene:
Search GeneIP for patents involving IFNA6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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