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IFNA6 Gene(Protein Coding)

Interferon Alpha 6

GCID:
GC09M021340
GIFtS:
49
Genes Participants
UDN Logo

Aliases for IFNA6 Gene

Aliases for IFNA6 Gene

  • Interferon Alpha 6 2 3
  • Interferon, Alpha 6 2 3 5
  • Interferon Alpha-54 3 4
  • Interferon Alpha-K 3 4
  • IFN-Alpha-6 3 4
  • LeIF K 3 4
  • IFN-AlphaK 3

External Ids for IFNA6 Gene

Previous GeneCards Identifiers for IFNA6 Gene

  • GC09M021677
  • GC09M021551

Summaries for IFNA6 Gene

GeneCards Summary for IFNA6 Gene

IFNA6 (Interferon Alpha 6) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Allograft rejection. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA6 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA6 Gene

Genomics for IFNA6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for IFNA6 Gene

Enhancers for IFNA6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFNA6 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IFNA6 gene promoter:

Genomic Location for IFNA6 Gene

Chromosome:
9
Start:
21,349,835 bp from pter
End:
21,351,378 bp from pter
Size:
1,544 bases
Orientation:
Minus strand

Genomic View for IFNA6 Gene

Genes around IFNA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IFNA6 Gene

Proteins for IFNA6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IFNA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05013-IFNA6_HUMAN
    Recommended name:
    Interferon alpha-6
    Protein Accession:
    P05013
    Secondary Accessions:
    • Q5VYQ1

    Protein attributes for IFNA6 Gene

    Size:
    189 amino acids
    Molecular mass:
    22141 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA6 Gene

Proteomics data for IFNA6 Gene at MOPED

Post-translational modifications for IFNA6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA6 Gene

Domains & Families for IFNA6 Gene

Gene Families for IFNA6 Gene

HGNC:

Protein Domains for IFNA6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IFNA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05013

UniProtKB/Swiss-Prot:

IFNA6_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA6: view

Function for IFNA6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for IFNA6 Gene

GENATLAS Biochemistry:
interferon type I,alpha 6,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Phenotypes for IFNA6 Gene

GenomeRNAi human phenotypes for IFNA6:
genes like me logo Genes that share phenotypes with IFNA6: view

Animal Model Products

miRNA for IFNA6 Gene

miRTarBase miRNAs that target IFNA6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFNA6 Gene

Localization for IFNA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA6 Gene COMPARTMENTS Subcellular localization image for IFNA6 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with IFNA6: view

Pathways & Interactions for IFNA6 Gene

genes like me logo Genes that share pathways with IFNA6: view

Gene Ontology (GO) - Biological Process for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
GO:0007596 blood coagulation TAS --
GO:0019221 cytokine-mediated signaling pathway IBA,TAS --
genes like me logo Genes that share ontologies with IFNA6: view

No data available for SIGNOR curated interactions for IFNA6 Gene

Drugs & Compounds for IFNA6 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IFNA6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for IFNA6 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA6 Gene

No ASD Table

Relevant External Links for IFNA6 Gene

GeneLoc Exon Structure for
IFNA6
ECgene alternative splicing isoforms for
IFNA6

Expression for IFNA6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for IFNA6 Gene

mRNA expression in normal human tissues for IFNA6 Gene
mRNA expression by BioGPS for IFNA6 GenemRNA expression by GTEx for IFNA6 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA6 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x6.2), Brain - Hippocampus (x4.5), and Brain - Amygdala (x4.5).

SOURCE GeneReport for Unigene cluster for IFNA6 Gene Hs.533470

genes like me logo Genes that share expression patterns with IFNA6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFNA6 Gene

Orthologs for IFNA6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IFNA6 35
  • 99.12 (n)
  • 98.94 (a)
IFNA6 36
  • 99 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia -- 36
  • 63 (a)
 ManyToMany
-- 36
  • 64 (a)
 ManyToMany
-- 36
  • 65 (a)
 ManyToMany
-- 36
  • 63 (a)
 ManyToMany
-- 36
  • 64 (a)
 ManyToMany
IFNAA 36
  • 63 (a)
 ManyToMany
IFNAG 36
  • 65 (a)
 ManyToMany
IFNAG 36
  • 65 (a)
 ManyToMany
IFNAH 36
  • 62 (a)
 ManyToMany
INFAF 36
  • 62 (a)
 ManyToMany
mouse
(Mus musculus)
 Mammalia Gm12597 36
  • 61 (a)
 ManyToMany
Gm13280 36
  • 60 (a)
 ManyToMany
Ifna1 36
  • 59 (a)
 ManyToMany
Ifna11 36
  • 56 (a)
 ManyToMany
Ifna12 36
  • 60 (a)
 ManyToMany
Ifna13 36
  • 61 (a)
 ManyToMany
Ifna14 36
  • 58 (a)
 ManyToMany
Ifna2 36
  • 57 (a)
 ManyToMany
Ifna4 36
  • 55 (a)
 ManyToMany
Ifna5 36
  • 60 (a)
 ManyToMany
Ifna6 36
  • 61 (a)
 ManyToMany
Ifna7 36
  • 58 (a)
 ManyToMany
Ifna9 36
  • 59 (a)
 ManyToMany
Ifnab 36
  • 57 (a)
 ManyToMany
Species with no ortholog for IFNA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA6 Gene

ENSEMBL:
Gene Tree for IFNA6 (if available)
TreeFam:
Gene Tree for IFNA6 (if available)

Paralogs for IFNA6 Gene

Paralogs for IFNA6 Gene

(18) SIMAP similar genes for IFNA6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA6: view

Variants for IFNA6 Gene

Sequence variations from dbSNP and Humsavar for IFNA6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs112972784 -- 21,351,249(+) TGTAT(A/G)TCTAC upstream-variant-2KB
rs113425651 -- 21,352,245(+) AACTC(C/G)AATCC upstream-variant-2KB
rs113882251 -- 21,351,366(+) TTAAC(C/T)TAACT upstream-variant-2KB
rs114283047 -- 21,350,804(+) TGGGT(C/T)TGAGG reference, synonymous-codon
rs115050731 -- 21,350,298(+) AGTCG(A/T)TTCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IFNA6 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892736 CNV Gain 21882294

Variation tolerance for IFNA6 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 10.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IFNA6 Gene

Disorders for IFNA6 Gene

Relevant External Links for IFNA6

Genetic Association Database (GAD)
IFNA6
Human Genome Epidemiology (HuGE) Navigator
IFNA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA6

No disorders were found for IFNA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA6 Gene

Publications for IFNA6 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 48 67
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  3. HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms. (PMID: 25972534) Reszka-Blanco N.J. … Su L. (J. Virol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Evidence for a different susceptibility of primate lentiviruses to type I interferons. (PMID: 23255800) Cordeil S. … Cimarelli A. (J. Virol. 2013) 3

Products for IFNA6 Gene

Sources for IFNA6 Gene

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