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Set Analyses:

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IFNA6 Gene

protein-coding GIFtS: 54
GCID: GC09M021340

Interferon, Alpha 6

Microbiology & Infectious Diseases Congress

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Interferon, Alpha 6¹ ²		IFN-alpha-6² ³
Interferon Alpha-54² ³		IFN-alphaK²
Interferon Alpha-K² ³		Interferon Alpha-6²
LeIF K² ³

External Ids:	HGNC: 5427¹	Entrez Gene: 3443²	Ensembl: ENSG00000120235⁷	OMIM: 147566⁵	UniProtKB: P05013³

Export aliases for IFNA6 gene to outside databases

Previous GC identifers: GC09M021677 GC09M021551

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFNA6 Gene:

IFNA6 (interferon, alpha 6) is a protein-coding gene. Diseases associated with IFNA6 include hiv/aids, and dengue hemorrhagic fever. GO annotations related to this gene include cytokine receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNA6_HUMAN, P05013

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of

two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA6 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000009.12 NC_018920.2 NT_008413.19

Regulatory elements:

Regulatory transcription factor binding sites in the IFNA6 gene promoter:
HEN1 Egr-3 Egr-2 IRF-7A NF-kappaB1 NF-kappaB Egr-4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for IFNA6

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNA6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22

IFNA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA6 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M021340: view genomic region (about GC identifiers)

Start:	21,349,834 bp from pter	End:	21,351,377 bp from pter
Size:	1,544 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IFNA6_HUMAN, P05013 (See protein sequence)

Recommended Name: Interferon alpha-6 precursor

Size: 189 amino acids; 22141 Da

Secondary accessions: Q5VYQ1

Explore the universe of human proteins at neXtProt for IFNA6: NX_P05013

Explore proteomics data for IFNA6 at MOPED

See IFNA6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_066282.1

ENSEMBL proteins:

ENSP00000369558

Reactome Protein details: P05013

IFNA6 Human Recombinant Protein Products:

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	Novus Biologicals IFNA6 Protein Novus Biologicals IFNA6 Lysates
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	Abcam antibodies for IFNA6
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	ThermoFisher Antibodies for IFNA6
	LSBio Antibodies in human, mouse, rat for IFNA6

IFNA6 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for IFNA6
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IFNA6
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

IFN: Interferons

4 InterPro protein domains:

IPR012351 4_helix_cytokine_core

IPR015589 Interferon_alpha

IPR000471 Interferon_alpha/beta/delta

IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P05013

ProtoNet protein and cluster: P05013

1 Blocks protein domain: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNA6_HUMAN, P05013

Similarity: Belongs to the alpha/beta interferon family

IFNA6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: IFNA6_HUMAN, P05013

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of

two enzymes: a protein kinase and an oligoadenylate synthetase

Genatlas biochemistry entry for IFNA6:

interferon type I,alpha 6,leukocyte

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IBA	--
GO:0005126	cytokine receptor binding	--	--
GO:0005132	type I interferon receptor binding	IBA	--

IFNA6 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for IFNA6:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFNA6

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFNA6

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNA6

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNA6

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		Predesigned siRNA for gene silencing in human, mouse, rat IFNA6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IFNA6

Clone Products:		OriGene clones in human, mouse for IFNA6 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Sino Biological Human cDNA Clone for IFNA6
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IFNA6
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA6

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

IFNA6_HUMAN, P05013: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IBA	--

IFNA6 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IFNA6 About (see all 21)

See pathways by source

SuperPath

Contained pathways About

Toll-like receptor signaling pathway

	Toll-like receptor signaling pathway	0.94			Regulation of toll-like receptor signaling pathway	0.93
	Toll-like receptor signaling pathway	0.94			Hepatitis B	0.31

Immune response IFN alpha beta signaling pathway

	Immune response IFN alpha beta signaling pathway	0.69			Interferon alpha/beta signaling	0.43
	Regulation of IFNA signaling	0.69

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	0.47			TRAF6 mediated IRF7 activation	0.40
	RIG-I-like receptor signaling pathway	0.47

Influenza A

	Influenza A	0.34			Herpes simplex infection	0.33
	Measles	0.34

Interferon Signaling

Interferon Signaling

0.59

Cytokine Signaling in Immune system

0.59

Pathways by source See SuperPaths
Show all pathways

4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IFNA6

	Cytokine Network
	Interferon Pathway
	JAK-STAT Pathway
	all-trans-Retinoic Acid Mediated Apoptosis

2 GeneGo (Thomson Reuters) Pathways for IFNA6

	Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
	Immune response IFN alpha/beta signaling pathway

2 BioSystems Pathways for IFNA6

	Toll-like receptor signaling pathway
	Regulation of toll-like receptor signaling pathway

4 Reactome Pathways for IFNA6

	Regulation of IFNA signaling
	Interferon alpha/beta signaling
	Factors involved in megakaryocyte development and platelet production
	TRAF6 mediated IRF7 activation

Selected Kegg Pathways (Kegg details for IFNA6) (see all 15):

	Cytokine-cytokine receptor interaction
	Regulation of autophagy
	PI3K-Akt signaling pathway
	Toll-like receptor signaling pathway
	RIG-I-like receptor signaling pathway

IFNA6 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including IFNA6:

Interferons & Receptors in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for IFNA6

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

Selected Interacting proteins for IFNA6 (P05013³ ENSP00000369558⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GKAP1	Q5VSY0³	I2D: score=1
KLHL12	Q53G59³	I2D: score=1
MAGEA11	P43364³	I2D: score=1
PLSCR1	O15162³	I2D: score=1
IFNA14	ENSP00000369571⁴	STRING: ENSP00000369571

About this table

Gene Ontology (GO): Selected biological process terms (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002250	adaptive immune response	IBA	--
GO:0002286	T cell activation involved in immune response	IBA	--
GO:0002323	natural killer cell activation involved in immune response	IBA	--
GO:0006952	defense response	--	--
GO:0006959	humoral immune response	IBA	--

IFNA6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for IFNA6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IFNA6 gene:

NM_021002.2

Unigene Cluster for IFNA6:

Interferon, alpha 6

Hs.533470

Unigene Representative Sequence: BC069471

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000380210(uc011lni.2)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat IFNA6 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate IFNA6
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for IFNA6
		Predesigned siRNA for gene silencing in human, mouse, rat IFNA6

Clone Products:		OriGene clones in human, mouse for IFNA6 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNA6 (NM_021002)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA6

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IFNA6
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat IFNA6
		QuantiTect SYBR Green Assays in human, mouse, rat IFNA6
		QuantiFast Probe-based Assays in human, mouse, rat IFNA6

Additional mRNA sequence:

BC069471.1 BC096697.1 BC096710.1 BC096730.1 BC098357.1

1 DOTS entry:

DT.91811057

6 AceView cDNA sequences:

BC074956 NM_002172 V00542 BC069471 NM_021002 CR541921

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IFNA6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGATCCTTCT

About this image

IFNA6 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

IFNA6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.533470

Pathway & Disease-focused RT² Profiler PCR Array including IFNA6:

Interferons & Receptors in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IFNA6
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat IFNA6
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		QuantiFast Probe-based Assays in human, mouse, rat IFNA6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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--

ENSEMBL Gene Tree for IFNA6 (if available)
TreeFam Gene Tree for IFNA6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for IFNA6 gene

IFNA7² IFNA2² IFNA4² IFNE² IFNA14² IFNA5² IFNK² IFNA1²

IFNA21² IFNA17² IFNB1² IFNA13² IFNW1² IFNA16² IFNA10² IFNA8²

18 SIMAP similar genes for IFNA6 using alignment to 1 protein entry: IFNA6_HUMAN:

IFNA14 IFNA5 IFN-2 IFNA IFNA10 IFNA4

IFNA17 IFNA21 IFNA2 IFNA1 IFNA13 IFNA2B

IFNA7 IFNA16 IFNA8 IFNW1 IFNE IFNB1

IFNA6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183862257^1,2		--	21349841(+)	`AACTTC/GAGTAT`	1	--	ds500¹		0	--	--	--	--
rs189366345^1,2		--	21349900(+)	`GAGAAC/TCGGCT`	1	--	ds500¹		0	--	--	--	--
rs28383779^1,2	C,F	--	21349986(-)	`TAGTCG/TATGTA`	1	--	ds500¹ ese³		1		NA	120
rs192534612^1,2		--	21349987(+)	`ACATCA/GACTAA`	1	--	ds500¹		0	--	--	--	--
rs184384196^1,2		--	21350017(+)	`TTATGG/TTATCA`	1	--	ds500¹		0	--	--	--	--
rs2990142^1,2	C,H	--	21350049(+)	`TATGCA/TTTTAT`	1	--	ds500¹ ese³		9		NA WA CSA EA	369
rs2990143^1,2	C,F,A	--	21350050(+)	`ATGCTT/CTTATA`	1	--	ds500¹ ese³		3		WA NA EA	358
rs2990144^1,2	C,F,A	--	21350078(+)	`ATTATA/TGTCAA`	1	--	ds500¹		6		WA CSA NA EA	366
rs16938352^1,2	C,F	--	21350168(+)	`CACGAT/CGTTGC`	1	--	ds500¹ ese³		5		NA CSA WA	262
rs12375790^1,2	C,H	--	21350174(+)	`GTTGCT/CTAACA`	1	--	ds500¹		4		NS EA	420
rs190195987^1,2		--	21350244(+)	`AGTCTA/TTAAAA`	1	--	ds500¹		0	--	--	--	--
rs201569487^1,2	C	--	21350283(+)	`TAGTCA/GTCAAT`	1	--	ds500¹		0	--	--	--	--
rs115050731^1,2	C,F	--	21350297(+)	`AGTCGT/ATTCTG`	1	--	ds500¹		1		WA	118
rs28383778^1,2	C,F,H	--	21350304(-)	`TCCAAC/AACAGA`	1	--	ds500¹ ese³		3		NS EU	1595
rs200866459^1,2	C	--	21350366(+)	`AGAAGC/GATCTC`	2	S C	mis¹		0	--	--	--	--
rs202179791^1,2	C	--	21350423(+)	`TCTCTG/TTCAGG`	2	K T	mis¹		0	--	--	--	--
rs61736258^1,2	C,F	--	21350487(+)	`CATCAG/AGGGAG`	2	/L	syn¹		4		NS CSA WA NA	4726
rs142796435^1,2	C	--	21350577(+)	`TAGAAA/GCCTCT`	2	L F	mis¹		0	--	--	--	--
rs147415542^1,2	C	--	21350595(+)	`AGCAAC/TAGATG`	2	I V	mis¹		0	--	--	--	--
rs76096785^1,2	C,F	--	21350603(+)	`ATGAGT/CCCTTT`	2	/D /G	mis¹		3		WA NA EU	5993
rs186416653^1,2	C	--	21350604(+)	`TGAGTC/TCTTTG`	2	N D	mis¹		0	--	--	--	--
rs2988573^1,2	C,F,A,H	--	21350620(+)	`AAGAGG/ATTGAA`	2	/N	syn¹ ese³		12		EA NA NS WA CSA EU	7797
rs189717919^1,2	C	--	21350627(+)	`TGAAGG/TTCTGC`	2	N T	mis¹		0	--	--	--	--
rs112773436^1,2	C,F	--	21350634(+)	`CTGCTG/AAATCA`	2	/Q /*	stg¹		2		CSA NA	4554
rs141284622^1,2	C	--	21350640(+)	`AATCAC/ACTCAT`	2	/V /L	mis¹		1		NA	4552
rs61736257^1,2	C,F	--	21350701(+)	`TCCTGG/AGGAAA`	2	/P	syn¹		3		NS NA EU	5933
rs201824804^1,2	C	--	21350709(+)	`AAATCT/CGAAGT`	2	/R /G	mis¹		1		EU	1317
rs200999463^1,2	C	--	21350710(+)	`AATCTG/AAAGTC`	2	/F	syn¹		1		EU	1317
rs61736255^1,2	C,F	--	21350731(+)	`TTCAGA/GCAGGA`	2	C	syn¹		3		NS NA EU	5943
rs61736254^1,2	C,F	--	21350741(+)	`AGAAAA/GGAGAG`	2	P L	mis¹		3		NS NA EU	5945
rs190705153^1,2		--	21350748(+)	`AGAGAC/TTCTCC`	2	I V	mis¹		0	--	--	--	--
rs114283047^1,2	C,F	--	21350803(+)	`TGGGTC/TTGAGG`	2	Q	syn¹		2		WA NA	4668
rs199909475^1,2		--	21350886(+)	`AGCCAC/TTGTAG`	2	M V	mis¹		0	--	--	--	--
rs138085325^1,2	C	--	21350904(+)	`AGATGC/TTGTTG`	1	--	us2k¹		0	--	--	--	--
rs10123853^1,2	C,F,H	--	21350910(+)	`TGTTGG/CACTTG`	1	--	us2k¹ ese³		7		NS EA CSA WA	543
rs181850780^1,2		--	21350937(+)	`TGAACC/TTTCAG`	1	--	us2k¹		0	--	--	--	--
rs187414422^1,2	C	--	21350942(+)	`CTTCAA/GCTCTA`	1	--	us2k¹		0	--	--	--	--
rs117181746^1,2	C,F	--	21351015(+)	`TCAGAA/GTTTAC`	1	--	us2k¹		1		EA	120
rs191750559^1,2		--	21351028(+)	`TCTACA/GTCTGA`	1	--	us2k¹		0	--	--	--	--
rs149536695^1,2		--	21351168(+)	`AGAAAC/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs183577776^1,2	C	--	21351221(+)	`ATATTA/G/TTATAT`	1	--	us2k¹		0	--	--	--	--
rs112972784^1,2	F	--	21351248(+)	`TGTATG/ATCTAC`	1	--	us2k¹		2		CSA	4
rs10124601^1,2	C,F,A,H	--	21351481(+)	`GACATG/ACATAA`	1	--	us2k¹		6		NS EA NA CSA	422
rs188138115^1,2		--	21351507(+)	`AAAATG/TAAATT`	1	--	us2k¹		0	--	--	--	--
rs10124647^1,2	C,A	--	21351611(+)	`ccagaG/Ttgtca`	1	--	us2k¹		0	--	--	--	--
rs182109500^1,2		--	21351649(+)	`TTAACC/TGTTGA`	1	--	us2k¹		0	--	--	--	--
rs186830539^1,2		--	21351650(+)	`TAACTA/GTTGAT`	1	--	us2k¹		0	--	--	--	--
rs10124651^1,2	C,F,H	--	21351656(+)	`ttgatG/Atgttg`	1	--	us2k¹		4		NS EA	420
rs143663439^1,2		--	21351826(+)	`TATTCA/GCCATA`	1	--	us2k¹		0	--	--	--	--
rs184897103^1,2		--	21351918(+)	`AATTCA/GATAAG`	1	--	us2k¹		0	--	--	--	--
rs12351654^1,2	H	--	21351938(+)	`cactaG/Aagaat`	1	--	us2k¹		4		NS EA	416
rs28697058^1,2	F	--	21351944(+)	`AGAATG/AAGATT`	1	--	us2k¹		1		CSA	2
rs193072517^1,2		--	21351956(+)	`TGTAAA/GAATTG`	1	--	us2k¹		0	--	--	--	--
rs185232370^1,2		--	21352075(+)	`TTTGAA/TAATAT`	1	--	us2k¹		0	--	--	--	--
rs146327067^1,2		--	21352084(+)	`ATCATC/GAATTT`	1	--	us2k¹		0	--	--	--	--
rs17334047^1,2	C,F	--	21352135(-)	`TAAATA/GTATGT`	1	--	us2k¹		3		CSA WA NA	240
rs28507568^1,2	F	--	21352156(+)	`ACCAAG/CTCAAT`	1	--	us2k¹		1		CSA	2
rs35101870^1,2	C,F	--	21352175(-)	`TTTCTC/TTTTGT`	1	--	us2k¹		2		WA NA	238
rs144392973^1,2		--	21352205(+)	`ATAACC/TGGATA`	1	--	us2k¹		0	--	--	--	--
rs113425651^1,2	C	--	21352244(+)	`AACTCG/CAATCC`	1	--	us2k¹		1		CSA	2
rs141073363^1,2	C	--	21352289(+)	`AAGTTC/GCCTCA`	1	--	us2k¹		0	--	--	--	--
rs189731991^1,2		--	21352301(+)	`ACCTAC/TAGATT`	1	--	us2k¹		0	--	--	--	--
rs9333356^1,2	C,F,H	--	21352377(-)	`GTCAAC/TAGAAC`	1	--	us2k¹		13		NS EA NA WA	1702
rs149854622^1,2		--	21352401(+)	`GTACCA/TGGCCT`	1	--	us2k¹		0	--	--	--	--
rs181209043^1,2		--	21352416(+)	`TACTTA/CTTCAA`	1	--	us2k¹		0	--	--	--	--
rs144875355^1,2	C	--	21352468(+)	`ATACTA/GGAAGG`	1	--	us2k¹		0	--	--	--	--
rs35353365^1,2	C,F	--	21352483(-)	`GGTCAC/TCCATG`	1	--	us2k¹		1		NA	120
rs183481443^1,2		--	21352526(+)	`TTAGGA/TTTATA`	1	--	us2k¹		0	--	--	--	--
rs188147177^1,2		--	21352572(+)	`TAAGTA/GTCAAT`	1	--	us2k¹		0	--	--	--	--
rs180948329^1,2		--	21352579(+)	`CAATAA/GTGATT`	1	--	us2k¹		0	--	--	--	--
rs72699197^1,2	C,F	--	21352636(+)	`ATATAC/TGGCAC`	1	--	us2k¹		2		WA NA	238
rs149027074^1,2		--	21352671(+)	`ATAATA/TTTCAG`	1	--	us2k¹		0	--	--	--	--
rs614541^1,2	C,F,O,A,H	--	21352862(+)	`TAGTAC/TCCCTG`	1	--	us2k¹		24		NS EA NA WA	2828
rs141102746^1,2	--	--	21350476(+)	`GAGTCC/TTCATT`	2	E	syn¹		1		NA	4552
rs368763578^1,2	--	--	21350197(+)	`CTTGAC/TCGTTT`	1	--	ds500¹		0	--	--	--	--
rs374477672^1,2	--	--	21352181(+)	`GAGAA-/CCATCT`	1	--	us2k¹		0	--	--	--	--
rs370554168^1,2	--	--	21351179(+)	`TCTTAA/TTTGAA`	1	--	us2k¹		0	--	--	--	--
rs373174690^1,2	--	--	21351293(+)	`TTTATG/TTTTCT`	1	--	us2k¹		0	--	--	--	--
rs373172024^1,2	--	--	21350123(+)	`CATCAG/TCTTAG`	1	--	ds500¹		0	--	--	--	--
rs370874088^1,2	--	--	21350343(+)	`TTCTTG/TCAAGT`	2	K Q	mis¹		0	--	--	--	--
rs377258038^1,2	--	--	21352116(+)	`TTAAAG/TTCAAA`	1	--	us2k¹		0	--	--	--	--
rs375649668^1,2	--	--	21350602(+)	`GATGAA/GTCCTT`	2	D	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IFNA6 (21349834 - 21351377 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for IFNA6: About this table

Variant ID	Type	Subtype	PubMed ID
nsv892724	CNV	Gain	21882294
nsv892736	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147566 OMIM disorders: --

18 diseases for IFNA6:
About MalaCards

hiv/aids dengue hemorrhagic fever hemorrhagic fever measles

subacute sclerosing panencephalitis autoimmune thyroiditis bronchiolitis hiv-1

cutaneous malignant melanoma hepatitis c virus influenza hepatitis c

hepatitis b tuberculosis hepatitis thyroiditis

herpes simplex melanoma

IFNA6 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Genetic Association Database (GAD): IFNA6
Human Genome Epidemiology (HuGE) Navigator: IFNA6 (7 documents)

Export disorders for IFNA6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IFNA6 gene, integrated from 10 sources (see all 63):
(articles sorted by number of sources associating them with IFNA6)

Utopia: connect your pdf to the dynamic
world of online information

Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)^{1, 4} Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)^{1, 4} Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PubMed id 20574843)^{1, 4} Yang X.R....Goldstein A.M. (Fam. Cancer 2010)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (J. Infect. Dis. 2007)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (Protein Sci. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)^{1, 3} Olopade O.I....Diaz M.O. (Genomics 1992)
Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)^{1, 2} Henco K.... Weissmann C. (J. Mol. Biol. 1985)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3443	HGNC: 5427	AceView: IFNA14	Ensembl:ENSG00000120235	euGenes: HUgn3443
ECgene: IFNA6	Kegg: 3443	H-InvDB: IFNA6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IFNA6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IFNA6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IFNA6 gene:
Search GeneIP for patents involving IFNA6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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