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Aliases for IFNA6 Gene

Aliases for IFNA6 Gene

  • Interferon, Alpha 6 2 3
  • Interferon Alpha-54 3 4
  • Interferon Alpha-K 3 4
  • IFN-Alpha-6 3 4
  • LeIF K 3 4
  • Interferon Alpha-6 3
  • IFN-AlphaK 3

External Ids for IFNA6 Gene

Summaries for IFNA6 Gene

GeneCards Summary for IFNA6 Gene

IFNA6 (Interferon, Alpha 6) is a Protein Coding gene. Diseases associated with IFNA6 include hiv-1. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and cytokine receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA6 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA6 Gene

Genomics for IFNA6 Gene

Genomic Location for IFNA6 Gene

Start:
21,349,835 bp from pter
End:
21,351,378 bp from pter
Size:
1,544 bases
Orientation:
Minus strand

Genomic View for IFNA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA6 Gene

Regulatory Elements for IFNA6 Gene

Proteins for IFNA6 Gene

  • Protein details for IFNA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05013-IFNA6_HUMAN
    Recommended name:
    Interferon alpha-6
    Protein Accession:
    P05013
    Secondary Accessions:
    • Q5VYQ1

    Protein attributes for IFNA6 Gene

    Size:
    189 amino acids
    Molecular mass:
    22141 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA6 Gene

Proteomics data for IFNA6 Gene at MOPED

Post-translational modifications for IFNA6 Gene

No Post-translational modifications

Other Protein References for IFNA6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA6 Gene

Domains for IFNA6 Gene

Gene Families for IFNA6 Gene

HGNC:
  • IFN :Interferons

Suggested Antigen Peptide Sequences for IFNA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05013

UniProtKB/Swiss-Prot:

IFNA6_HUMAN
Family:
  • Belongs to the alpha/beta interferon family.:
    • P05013
genes like me logo Genes that share domains with IFNA6: view

Function for IFNA6 Gene

Molecular function for IFNA6 Gene

GENATLAS Biochemistry: interferon type I,alpha 6,leukocyte
UniProtKB/Swiss-Prot Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Ontology (GO) - Molecular Function for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA6: view

Phenotypes for IFNA6 Gene

GenomeRNAi human phenotypes for IFNA6:
genes like me logo Genes that share phenotypes with IFNA6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNA6 Gene

Localization for IFNA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA6 Gene COMPARTMENTS Subcellular localization image for IFNA6 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA6: view

Pathways for IFNA6 Gene

genes like me logo Genes that share pathways with IFNA6: view

Gene Ontology (GO) - Biological Process for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA6: view

Transcripts for IFNA6 Gene

mRNA/cDNA for IFNA6 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA6 Gene

No ASD Table

Relevant External Links for IFNA6 Gene

GeneLoc Exon Structure for
IFNA6
ECgene alternative splicing isoforms for
IFNA6

Expression for IFNA6 Gene

mRNA expression in normal human tissues for IFNA6 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA6 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (6.5), Brain - Putamen (basal ganglia) (6.2), Brain - Hippocampus (4.5), and Brain - Amygdala (4.5).

SOURCE GeneReport for Unigene cluster for IFNA6 Gene Hs.533470

genes like me logo Genes that share expressions with IFNA6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for IFNA6 Gene

Orthologs for IFNA6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA6 35
  • 99.12 (n)
  • 98.94 (a)
IFNA6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
IFNAA 36
  • 63 (a)
ManyToMany
IFNAG 36
  • 65 (a)
ManyToMany
IFNAG 36
  • 65 (a)
ManyToMany
IFNAH 36
  • 62 (a)
ManyToMany
INFAF 36
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 36
  • 61 (a)
ManyToMany
Gm13280 36
  • 60 (a)
ManyToMany
Ifna1 36
  • 59 (a)
ManyToMany
Ifna11 36
  • 56 (a)
ManyToMany
Ifna12 36
  • 60 (a)
ManyToMany
Ifna13 36
  • 61 (a)
ManyToMany
Ifna14 36
  • 58 (a)
ManyToMany
Ifna2 36
  • 57 (a)
ManyToMany
Ifna4 36
  • 55 (a)
ManyToMany
Ifna5 36
  • 60 (a)
ManyToMany
Ifna6 36
  • 61 (a)
ManyToMany
Ifna7 36
  • 58 (a)
ManyToMany
Ifna9 36
  • 59 (a)
ManyToMany
Ifnab 36
  • 57 (a)
ManyToMany
Species with no ortholog for IFNA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA6 Gene

ENSEMBL:
Gene Tree for IFNA6 (if available)
TreeFam:
Gene Tree for IFNA6 (if available)

Paralogs for IFNA6 Gene

Selected SIMAP similar genes for IFNA6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA6: view

Variants for IFNA6 Gene

Sequence variations from dbSNP and Humsavar for IFNA6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs614541 -- 21,352,863(+) TAGTA(C/T)CCCTG upstream-variant-2KB
rs2988573 -- 21,350,621(+) AAGAG(A/G)TTGAA reference, synonymous-codon
rs2990142 -- 21,350,050(+) TATGC(A/T)TTTAT downstream-variant-500B
rs2990143 -- 21,350,051(+) ATGCT(C/T)TTATA downstream-variant-500B
rs2990144 -- 21,350,079(+) ATTAT(A/T)GTCAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IFNA6 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892736 CNV Gain 21882294

Relevant External Links for IFNA6 Gene

HapMap Linkage Disequilibrium report
IFNA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA6 Gene

Disorders for IFNA6 Gene

(1) MalaCards Diseases for IFNA6 Gene

Search for IFNA6 Gene in MalaCards »

Relevant External Links for IFNA6

Genetic Association Database (GAD)
IFNA6
Human Genome Epidemiology (HuGE) Navigator
IFNA6
genes like me logo Genes that share disorders with IFNA6: view

No data available for UniProtKB/Swiss-Prot for IFNA6 Gene

Publications for IFNA6 Gene

  1. Structural relationship of human interferon alpha genes and pseudogenes. (PMID: 4057246) Henco K. … Weissmann C. (J. Mol. Biol. 1985) 3 4
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PMID: 17703412) Janssen R. … Hoebee B. (J. Infect. Dis. 2007) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for IFNA6 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Interferons & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNA6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA6
    • Block miRNA regulation of IFNA6 using miScript Target Protectors

    Sources for IFNA6 Gene

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