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Aliases for IFNA5 Gene

Aliases for IFNA5 Gene

  • Interferon, Alpha 5 2 3
  • Interferon Alpha-61 3 4
  • Interferon Alpha-G 3 4
  • IFN-Alpha-5 3 4
  • LeIF G 3 4
  • IFN-AlphaG 3
  • INFA5 3
  • INA5 3

External Ids for IFNA5 Gene

Previous GeneCards Identifiers for IFNA5 Gene

  • GC09M021632
  • GC09M021505

Summaries for IFNA5 Gene

GeneCards Summary for IFNA5 Gene

IFNA5 (Interferon, Alpha 5) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA5 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA5 Gene

Genomics for IFNA5 Gene

Regulatory Elements for IFNA5 Gene

Genomic Location for IFNA5 Gene

Chromosome:
9
Start:
21,304,326 bp from pter
End:
21,305,313 bp from pter
Size:
988 bases
Orientation:
Minus strand

Genomic View for IFNA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IFNA5 Gene

Proteins for IFNA5 Gene

  • Protein details for IFNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01569-IFNA5_HUMAN
    Recommended name:
    Interferon alpha-5
    Protein Accession:
    P01569
    Secondary Accessions:
    • Q52LX3

    Protein attributes for IFNA5 Gene

    Size:
    189 amino acids
    Molecular mass:
    21942 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA5 Gene

Proteomics data for IFNA5 Gene at MOPED

Post-translational modifications for IFNA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IFNA5 Gene

Domains & Families for IFNA5 Gene

Gene Families for IFNA5 Gene

Suggested Antigen Peptide Sequences for IFNA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01569

UniProtKB/Swiss-Prot:

IFNA5_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA5: view

Function for IFNA5 Gene

Molecular function for IFNA5 Gene

GENATLAS Biochemistry:
interferon type I,alpha 5,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Ontology (GO) - Molecular Function for IFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA5: view

Phenotypes for IFNA5 Gene

GenomeRNAi human phenotypes for IFNA5:
genes like me logo Genes that share phenotypes with IFNA5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA5 Gene

Localization for IFNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA5 Gene COMPARTMENTS Subcellular localization image for IFNA5 gene
Compartment Confidence
extracellular 5
chloroplast 1

Gene Ontology (GO) - Cellular Components for IFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA5: view

Pathways & Interactions for IFNA5 Gene

genes like me logo Genes that share pathways with IFNA5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Common Cytokines in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat

Interacting Proteins for IFNA5 Gene

Selected Interacting proteins: P01569-IFNA5_HUMAN for IFNA5 Gene via I2D

Symbol External ID(s) Details
IFNAR2

Gene Ontology (GO) - Biological Process for IFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA5: view

No data available for SIGNOR curated interactions for IFNA5 Gene

Drugs & Compounds for IFNA5 Gene

(1) Drugs for IFNA5 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 341
genes like me logo Genes that share compounds with IFNA5: view

Transcripts for IFNA5 Gene

mRNA/cDNA for IFNA5 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA5 Gene

No ASD Table

Relevant External Links for IFNA5 Gene

GeneLoc Exon Structure for
IFNA5
ECgene alternative splicing isoforms for
IFNA5

Expression for IFNA5 Gene

mRNA expression in normal human tissues for IFNA5 Gene

Protein differential expression in normal tissues from HIPED for IFNA5 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFNA5 Gene



SOURCE GeneReport for Unigene cluster for IFNA5 Gene Hs.37113

genes like me logo Genes that share expression patterns with IFNA5: view

Protein tissue co-expression partners for IFNA5 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFNA5 Gene

Orthologs for IFNA5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA5 35
  • 98.94 (n)
  • 98.41 (a)
IFNA5 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
IFNAA 36
  • 61 (a)
ManyToMany
IFNAG 36
  • 63 (a)
ManyToMany
IFNAG 36
  • 63 (a)
ManyToMany
IFNAH 36
  • 61 (a)
ManyToMany
INFAF 36
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 36
  • 59 (a)
ManyToMany
Gm13280 36
  • 59 (a)
ManyToMany
Ifna1 36
  • 60 (a)
ManyToMany
Ifna11 36
  • 58 (a)
ManyToMany
Ifna12 36
  • 60 (a)
ManyToMany
Ifna13 36
  • 62 (a)
ManyToMany
Ifna14 36
  • 58 (a)
ManyToMany
Ifna2 36
  • 57 (a)
ManyToMany
Ifna4 36
  • 56 (a)
ManyToMany
Ifna5 36
  • 60 (a)
ManyToMany
Ifna6 36
  • 61 (a)
ManyToMany
Ifna7 36
  • 57 (a)
ManyToMany
Ifna9 36
  • 60 (a)
ManyToMany
Ifnab 36
  • 58 (a)
ManyToMany
Species with no ortholog for IFNA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA5 Gene

ENSEMBL:
Gene Tree for IFNA5 (if available)
TreeFam:
Gene Tree for IFNA5 (if available)

Paralogs for IFNA5 Gene

(18) SIMAP similar genes for IFNA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA5: view

Variants for IFNA5 Gene

Sequence variations from dbSNP and Humsavar for IFNA5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1952691 -- 21,306,020(+) aaaaa(A/C)ctttt upstream-variant-2KB
rs7027327 -- 21,305,856(+) atata(A/G)tattg upstream-variant-2KB
rs7031048 -- 21,306,319(+) cttcc(A/G)tgaac upstream-variant-2KB
rs10757212 -- 21,304,804(+) TAGAG(A/G)GTGAT reference, synonymous-codon
rs10964964 -- 21,306,574(+) AGGGA(G/T)TCGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNA5 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv438097 CNV Loss 16468122

Variation tolerance for IFNA5 Gene

Residual Variation Intolerance Score: 79.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA5 Gene

HapMap Linkage Disequilibrium report
IFNA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA5 Gene

Disorders for IFNA5 Gene

Relevant External Links for IFNA5

Genetic Association Database (GAD)
IFNA5
Human Genome Epidemiology (HuGE) Navigator
IFNA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA5
genes like me logo Genes that share disorders with IFNA5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA5 Gene

Publications for IFNA5 Gene

  1. Human CD34+ hematopoietic cells transduced by retrovirus-mediated interferon alpha gene maintains regeneration capacity and engraftment in NOD/SCID mice. (PMID: 10517492) Quan S. … Ahmed T. (Exp. Hematol. 1999) 23 67
  2. A phase II study of carboplatin, cisplatin, interferon-alpha, and tamoxifen for patients with metastatic melanoma. (PMID: 9679527) Gause B.L. … Longo D.L. (Cancer Invest. 1998) 23 67
  3. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 67
  4. Tamoxifen and alpha interferon in advanced breast cancer. (PMID: 1819622) Miglietta L. … Pronzato P. (J Chemother 1991) 23 67
  5. Prolonged treatment (18 months) of chronic hepatitis C with recombinant alpha-interferon in comparison with a control group. (PMID: 2127790) GA^mez-Rubio M. … CarreA+o V. (J. Hepatol. 1990) 23 67

Products for IFNA5 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Common Cytokines in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNA5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA5
    • Block miRNA regulation of IFNA5 using miScript Target Protectors

    Sources for IFNA5 Gene

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