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Aliases for IFNA5 Gene

Aliases for IFNA5 Gene

  • Interferon Alpha 5 2 3
  • Interferon, Alpha 5 2 3 5
  • Interferon Alpha-61 3 4
  • Interferon Alpha-G 3 4
  • IFN-Alpha-5 3 4
  • LeIF G 3 4
  • IFN-AlphaG 3
  • INFA5 3
  • INA5 3

External Ids for IFNA5 Gene

Previous GeneCards Identifiers for IFNA5 Gene

  • GC09M021632
  • GC09M021505

Summaries for IFNA5 Gene

GeneCards Summary for IFNA5 Gene

IFNA5 (Interferon Alpha 5) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Allograft rejection. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA5 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA5 Gene

Genomics for IFNA5 Gene

Regulatory Elements for IFNA5 Gene

Enhancers for IFNA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFNA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNA5 Gene

21,304,326 bp from pter
21,305,313 bp from pter
988 bases
Minus strand

Genomic View for IFNA5 Gene

Genes around IFNA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA5 Gene

Proteins for IFNA5 Gene

  • Protein details for IFNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-5
    Protein Accession:
    Secondary Accessions:
    • Q52LX3

    Protein attributes for IFNA5 Gene

    189 amino acids
    Molecular mass:
    21942 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA5 Gene

Proteomics data for IFNA5 Gene at MOPED

Post-translational modifications for IFNA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA5 Gene

Domains & Families for IFNA5 Gene

Gene Families for IFNA5 Gene

Suggested Antigen Peptide Sequences for IFNA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA5: view

Function for IFNA5 Gene

Molecular function for IFNA5 Gene

GENATLAS Biochemistry:
interferon type I,alpha 5,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
genes like me logo Genes that share phenotypes with IFNA5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA5 Gene

Localization for IFNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA5 Gene


Subcellular locations from

Jensen Localization Image for IFNA5 Gene COMPARTMENTS Subcellular localization image for IFNA5 gene
Compartment Confidence
extracellular 5
chloroplast 1

No data available for Gene Ontology (GO) - Cellular Components for IFNA5 Gene

Pathways & Interactions for IFNA5 Gene

genes like me logo Genes that share pathways with IFNA5: view

Interacting Proteins for IFNA5 Gene

Selected Interacting proteins: P01569-IFNA5_HUMAN for IFNA5 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
GO:0007596 blood coagulation TAS --
GO:0019221 cytokine-mediated signaling pathway IBA,TAS --
genes like me logo Genes that share ontologies with IFNA5: view

No data available for SIGNOR curated interactions for IFNA5 Gene

Drugs & Compounds for IFNA5 Gene

(1) Drugs for IFNA5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IFNA5: view

Transcripts for IFNA5 Gene

mRNA/cDNA for IFNA5 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA5 Gene

No ASD Table

Relevant External Links for IFNA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA5 Gene

mRNA expression in normal human tissues for IFNA5 Gene

Protein differential expression in normal tissues from HIPED for IFNA5 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFNA5 Gene

SOURCE GeneReport for Unigene cluster for IFNA5 Gene Hs.37113

genes like me logo Genes that share expression patterns with IFNA5: view

Protein tissue co-expression partners for IFNA5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFNA5 Gene

Orthologs for IFNA5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNA5 35
  • 98.94 (n)
  • 98.41 (a)
IFNA5 36
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 64 (a)
-- 36
  • 62 (a)
-- 36
  • 63 (a)
-- 36
  • 62 (a)
-- 36
  • 63 (a)
  • 61 (a)
  • 63 (a)
  • 63 (a)
  • 61 (a)
  • 62 (a)
(Mus musculus)
Mammalia Gm12597 36
  • 59 (a)
Gm13280 36
  • 59 (a)
Ifna1 36
  • 60 (a)
Ifna11 36
  • 58 (a)
Ifna12 36
  • 60 (a)
Ifna13 36
  • 62 (a)
Ifna14 36
  • 58 (a)
Ifna2 36
  • 57 (a)
Ifna4 36
  • 56 (a)
Ifna5 36
  • 60 (a)
Ifna6 36
  • 61 (a)
Ifna7 36
  • 57 (a)
Ifna9 36
  • 60 (a)
Ifnab 36
  • 58 (a)
Species with no ortholog for IFNA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA5 Gene

Gene Tree for IFNA5 (if available)
Gene Tree for IFNA5 (if available)

Paralogs for IFNA5 Gene

(18) SIMAP similar genes for IFNA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA5: view

Variants for IFNA5 Gene

Sequence variations from dbSNP and Humsavar for IFNA5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs113459886 -- 21,304,587(+) CTCAA(A/G)TCATG downstream-variant-500B
rs1952691 -- 21,306,020(+) aaaaa(A/C)ctttt upstream-variant-2KB
rs114744308 -- 21,304,306(+) AATGA(A/G)CAAAG downstream-variant-500B
rs192452328 -- 21,305,639(+) CTTTA(A/T)AAGCA upstream-variant-2KB
rs138121530 -- 21,305,049(+) GAACT(C/G/T)GTTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IFNA5 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv438097 CNV Loss 16468122

Variation tolerance for IFNA5 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IFNA5 Gene

Disorders for IFNA5 Gene

Relevant External Links for IFNA5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IFNA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA5 Gene

Publications for IFNA5 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 48 67
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  3. HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms. (PMID: 25972534) Reszka-Blanco N.J. … Su L. (J. Virol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Evidence for a different susceptibility of primate lentiviruses to type I interferons. (PMID: 23255800) Cordeil S. … Cimarelli A. (J. Virol. 2013) 3

Products for IFNA5 Gene

Sources for IFNA5 Gene