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Aliases for IFNA4 Gene

Aliases for IFNA4 Gene

  • Interferon Alpha 4 2 3 5
  • Interferon Alpha-4B 3 4
  • Interferon Alpha-76 3 4
  • Interferon Alpha-M1 3 4
  • IFN-Alpha-4 3 4
  • Interferon Alpha-4 3
  • IFN-Alpha4a 3
  • INFA4 3

External Ids for IFNA4 Gene

Previous GeneCards Identifiers for IFNA4 Gene

  • GC09M021514
  • GC09M021387
  • GC09M021176
  • GC09M021149

Summaries for IFNA4 Gene

GeneCards Summary for IFNA4 Gene

IFNA4 (Interferon Alpha 4) is a Protein Coding gene. Diseases associated with IFNA4 include Rabies. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA10.

UniProtKB/Swiss-Prot for IFNA4 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA4 Gene

Additional gene information for IFNA4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA4 Gene

Genomics for IFNA4 Gene

Regulatory Elements for IFNA4 Gene

Enhancers for IFNA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H021183 0.5 Ensembl 0.7 +4.2 4240 0 CTCF ZNF654 TRIM22 RAD21 IFNA20P IFNA4 IFNWP15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFNA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNA4 Gene

Chromosome:
9
Start:
21,186,618 bp from pter
End:
21,187,671 bp from pter
Size:
1,054 bases
Orientation:
Minus strand

Genomic View for IFNA4 Gene

Genes around IFNA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA4 Gene

Proteins for IFNA4 Gene

  • Protein details for IFNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05014-IFNA4_HUMAN
    Recommended name:
    Interferon alpha-4
    Protein Accession:
    P05014
    Secondary Accessions:
    • P13358
    • Q14CS4
    • Q5VV15

    Protein attributes for IFNA4 Gene

    Size:
    189 amino acids
    Molecular mass:
    21808 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA4 Gene

Post-translational modifications for IFNA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IFNA4
  • Santa Cruz Biotechnology (SCBT) Antibodies for IFNA4

Protein Products

  • Abcam proteins for IFNA4

No data available for DME Specific Peptides for IFNA4 Gene

Domains & Families for IFNA4 Gene

Gene Families for IFNA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IFNA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05014

UniProtKB/Swiss-Prot:

IFNA4_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA4: view

Function for IFNA4 Gene

Molecular function for IFNA4 Gene

GENATLAS Biochemistry:
interferon type I,alpha 4,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS 3891272
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IFNA4: view
genes like me logo Genes that share phenotypes with IFNA4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IFNA4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA4 Gene

Localization for IFNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA4 Gene

Pathways & Interactions for IFNA4 Gene

genes like me logo Genes that share pathways with IFNA4: view

Gene Ontology (GO) - Biological Process for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA4: view

No data available for SIGNOR curated interactions for IFNA4 Gene

Drugs & Compounds for IFNA4 Gene

No Compound Related Data Available

Transcripts for IFNA4 Gene

mRNA/cDNA for IFNA4 Gene

(1) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IFNA4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA4 Gene

No ASD Table

Relevant External Links for IFNA4 Gene

GeneLoc Exon Structure for
IFNA4
ECgene alternative splicing isoforms for
IFNA4

Expression for IFNA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNA4 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNA4 Gene:

IFNA4

SOURCE GeneReport for Unigene cluster for IFNA4 Gene:

Hs.1510

Evidence on tissue expression from TISSUES for IFNA4 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with IFNA4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA4 Gene

Orthologs for IFNA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA17 33
  • 98.94 (n)
-- 34
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifna6 33 34
  • 76.04 (n)
Gm12597 34
  • 62 (a)
ManyToMany
Ifna13 34
  • 62 (a)
ManyToMany
Ifna5 34
  • 62 (a)
ManyToMany
Ifna1 34
  • 61 (a)
ManyToMany
Ifna12 34
  • 61 (a)
ManyToMany
Gm13280 34
  • 60 (a)
ManyToMany
Ifna9 34
  • 60 (a)
ManyToMany
Ifnab 16 34
  • 59 (a)
Ifna11 34
  • 59 (a)
ManyToMany
Ifna14 34
  • 59 (a)
ManyToMany
Ifna2 34
  • 59 (a)
ManyToMany
Ifna4 34
  • 58 (a)
ManyToMany
Ifna7 34
  • 58 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifna2 33
  • 75.27 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 64 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
IFNAG 34 34
  • 63 (a)
ManyToMany
IFNAH 34
  • 63 (a)
ManyToMany
-- 34
  • 62 (a)
ManyToMany
IFNAA 34
  • 62 (a)
ManyToMany
INFAF 34
  • 62 (a)
ManyToMany
Species where no ortholog for IFNA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA4 Gene

ENSEMBL:
Gene Tree for IFNA4 (if available)
TreeFam:
Gene Tree for IFNA4 (if available)

Paralogs for IFNA4 Gene

(18) SIMAP similar genes for IFNA4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA4: view

Variants for IFNA4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA4 Gene

IFNA4_HUMAN-P05014
Two forms exist; alpha-4a (shown here) and alpha-4b (PubMed:9335434). They seem to be equally abundant (PubMed:9335434).

Sequence variations from dbSNP and Humsavar for IFNA4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000338497 -- 21,188,418(+) ATATG(C/T)AGGTT upstream-variant-2KB
rs1001411417 -- 21,188,453(+) TTAAG(A/T)TCCAG upstream-variant-2KB
rs1003734990 -- 21,189,134(+) CCTCA(C/T)GGCCA upstream-variant-2KB
rs1003808795 -- 21,189,278(+) TTCAA(A/G)TTGCA upstream-variant-2KB
rs1005424956 -- 21,187,947(+) AAGTT(A/T)AAAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNA4 Gene

Variant ID Type Subtype PubMed ID
dgv7474n100 CNV loss 25217958
esv2738274 CNV deletion 23290073
esv2738275 CNV deletion 23290073
esv2759678 CNV loss 17122850
esv2764150 CNV gain+loss 21179565
esv3573167 CNV loss 25503493
esv3619950 CNV loss 21293372
nsv1033177 CNV gain 25217958
nsv613752 CNV loss 21841781
nsv613755 CNV loss 21841781
nsv968599 CNV duplication 23825009

Variation tolerance for IFNA4 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA4 Gene

Human Gene Mutation Database (HGMD)
IFNA4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA4

Disorders for IFNA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNA4 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
rabies
  • lyssa
- elite association - COSMIC cancer census association via MalaCards
Search IFNA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFNA4

Genetic Association Database (GAD)
IFNA4
Human Genome Epidemiology (HuGE) Navigator
IFNA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA4
genes like me logo Genes that share disorders with IFNA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA4 Gene

Publications for IFNA4 Gene

  1. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 45 60
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PMID: 9425112) Nyman TA … Kalkkinen N (The Biochemical journal 1998) 3 4 60
  5. Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population. (PMID: 9335434) Hussain M … Liao MJ (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997) 3 4 60

Products for IFNA4 Gene

Sources for IFNA4 Gene

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