IFNA4 Gene
protein-coding GIFtS: 53
GCID: GC09M021186
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|
interferon, alpha 4
| |
Aliases
for IFNA4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon, Alpha 41 2 | | IFN-Alpha-41 | | IFN-Alpha4a1 | | MGC1422001 | | Interferon Alpha-4B2 3 | | INFA42 | | Interferon Alpha-762 3 | | Interferon Alpha-42 | | Interferon Alpha-M12 3 | | |
Export aliases for IFNA4 gene to outside databasesPrevious GC identifers: GC09M021514 GC09M021387 GC09M021176 GC09M021149 |
Summaries
for IFNA4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IFNA4_HUMAN, P05014Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase
Gene Wiki entry for IFNA4
|
Genomic Views
for IFNA4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFNA4 gene promoter:
GR Egr-2 Olf-1 IRF-7A GR-alpha Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFNA4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22IFNA4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M021186: view genomic region
(about GC identifiers)
Start:
|
21,186,617 bp from pter |
End:
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21,187,598 bp from pter |
Size:
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982 bases |
Orientation:
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minus strand |
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Proteins
for IFNA4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFNA4_HUMAN, P05014 (See
protein sequence)Recommended Name: Interferon alpha-4 precursor Size: 189 amino acids; 21808 Da
Subcellular location: Secreted
Secondary accessions: P13358 Q14CS4 Q5VV15Explore the universe of human proteins at neXtProt for IFNA4: NX_P05014
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P05014
IFNA4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066546.1
ENSEMBL proteins: ENSP00000412897 Reactome Protein details: P05014
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005615 | extracellular space |
IEA | -- |
IFNA4 for ontologies About GeneDecksing
IFNA4 Antibody Products:
Assay Products for IFNA4: |
Protein
Domains /
Families
for IFNA4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFNA4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P05014ProtoNet protein and cluster: P05014 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFNA4_HUMAN, P05014Similarity: Belongs to the alpha/beta interferon family |
Function
for IFNA4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IFNA4_HUMAN, P05014Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase Genatlas biochemistry entry for IFNA4:interferon type I,alpha 4,leukocyte
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNA4 (NM_021068) | |  | Sino Biological Human cDNA Clone for IFNA4 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
IFNA4 for ontologies About GeneDecksing
|
Pathways & Interactions
for IFNA4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of IFNA signaling | | | 2 | Toll-like receptor signaling pathway | | | 3 | Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway | | | 4 | Cytokine Signaling in Immune system | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for IFNA4
1  R&D Systems Pathway for IFNA4
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA4
2  GeneGo (Thomson Reuters) Pathways for IFNA4
1  BioSystems Pathway for IFNA4
5/11 
Reactome Pathways for IFNA4 (see all 11)
5/12 
Kegg Pathways (Kegg details for IFNA4) (see all 12):
IFNA4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA4
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for IFNA4 (ENSP000004128974) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
IFNA4 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFNA4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFNA4
Search CenterWatch for drugs/clinical trials and news about IFNA4
|
Transcripts
for IFNA4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFNA4 gene: NM_021068.2 Unigene Cluster for IFNA4: Interferon, alpha 4 Hs.1510 Unigene Representative Sequence: NM_0210681 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000421715(uc003zon.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IFNA4 (NM_021068) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA4 |
Additional cDNA sequence: BC074965.2 BC074966.2 BC113640.1 BC113642.1 M27318.1 1 DOTS entry: DT.121148358 11 AceView cDNA sequences: BV199634 BV199637 BC074966 BC074965 BV199635 BV199636 BV199629 M27318 NM_021068 BV199642 BV199639
GeneLoc Exon Structure
|
Expression
for IFNA4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFNA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IFNA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA4
SOURCE GeneReport for Unigene cluster: Hs.1510
SABiosciences Expression via Pathway-Focused PCR Arrays including IFNA4: | Interferons & Receptors in human mouse rat | | Type I Interferon Response in human mouse rat | | Common Cytokines in human mouse rat | | Inflammatory Response & Autoimmunity 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFNA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA4 |
Orthologs
for IFNA4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFNA4 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for IFNA4 (if available)
TreeFam Gene Tree for IFNA4 (if available) |
Paralogs
for IFNA4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IFNA4 gene
- IFNA72 IFNA22 IFNE2 IFNA142 IFNK2 IFNA52 IFNA12 IFNA212
- IFNA172 IFNA62 IFNB12 IFNA132 IFNW12 IFNA162 IFNA102 IFNA82
18 SIMAP similar genes for IFNA4 using alignment to 1 protein entry: IFNA4_HUMAN:IFNA17 IFNA10 IFNA21 IFNA5 IFNA7 IFNA14
IFNA16 IFNA IFN-2 IFNA2 IFNA2B IFNA6
IFNA1 IFNA13 IFNA8 IFNW1 IFNB1 IFNE
IFNA4 for paralogs About GeneDecksing
|
Genomic Variants
for IFNA4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: IFNA4_HUMAN, P05014Polymorphism: Two forms exist; alpha-4a (shown here) and alpha-4b. They seem to be equally abundant
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFNA4 (21186617 - 21187598 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFNA4
1 CNV: 2805 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA4 |
|
Disorders
/ Diseases
for IFNA4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFNA4 for disorders About GeneDecksing
OMIM gene information: 147564
OMIM disorders: --
14  diseases for IFNA4: About MalaCardsdengue hemorrhagic fever hemorrhagic fever herpes simplex autoimmune thyroiditis
multiple sclerosis hepatitis c rabies hepatitis b
measles hepatitis influenza thyroiditis
tuberculosis melanoma
Human Genome Epidemiology (HuGE) Navigator: IFNA4 (2 documents)
Export disorders for IFNA4 gene to outside databases
|
Publications
for IFNA4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFNA4 gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with IFNA4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (1998)
- Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population. (PubMed id 9335434)1, 2 Hussain M.... Liao M.-J. (1997)
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
- Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)1, 2 Henco K.... Weissmann C. (1985)
- Nucleotide sequence and expression in E. coli of a human interferon- alpha gene selected from a genomic library using synthetic oligonucleotides. (PubMed id 6089830)1, 2 Linnane A.W.... Woodrow G.C. (1984)
- Inhibitory effects of human immunodeficiency virus gp1 20 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cel ls. (PubMed id 22814248)1 Fang M....Yao H. (2012)
- HIV-1 Gag-virus-like particles inhibit HIV-1 replicati on in dendritic cells and T cells through IFN-a-dependent upregulation of APOBEC 3G and 3F. (PubMed id 22739040)1 Chang M.O....Takaku H. (2012)
- Role of retroviral restriction factors in the interfer on-a-mediated suppression of HIV-1 in vivo. (PubMed id 22315404)1 Pillai S.K....Wong J.K. (2012)
|
External Searches for IFNA4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFNA4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFNA4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNA4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFNA4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IFNA4 gene:
Search GeneIP for patents involving IFNA4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFNA4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IFNA4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNA4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA4 | | | OriGene Protein Over-expression Lysate for IFNA4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IFNA4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IFNA4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IFNA4 | | OriGene Custom Protein Services for IFNA4 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNA4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA4 |
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 |  |  |  | |
| | | | Search Tocris compounds for IFNA4 |
| |  |  |  |  | | | | |
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 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for IFNA4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA4 |
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