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Aliases for IFNA4 Gene

Aliases for IFNA4 Gene

  • Interferon, Alpha 4 2 3
  • Interferon Alpha-4B 3 4
  • Interferon Alpha-76 3 4
  • Interferon Alpha-M1 3 4
  • IFN-Alpha-4 3 4
  • Interferon Alpha-4 3
  • IFN-Alpha4a 3
  • INFA4 3

External Ids for IFNA4 Gene

Previous GeneCards Identifiers for IFNA4 Gene

  • GC09M021514
  • GC09M021387
  • GC09M021176
  • GC09M021149

Summaries for IFNA4 Gene

GeneCards Summary for IFNA4 Gene

IFNA4 (Interferon, Alpha 4) is a Protein Coding gene. Diseases associated with IFNA4 include hiv-1. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA4 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA4 Gene

Genomics for IFNA4 Gene

Regulatory Elements for IFNA4 Gene

Genomic Location for IFNA4 Gene

21,186,618 bp from pter
21,187,671 bp from pter
1,054 bases
Minus strand

Genomic View for IFNA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA4 Gene

Proteins for IFNA4 Gene

  • Protein details for IFNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-4
    Protein Accession:
    Secondary Accessions:
    • P13358
    • Q14CS4
    • Q5VV15

    Protein attributes for IFNA4 Gene

    189 amino acids
    Molecular mass:
    21808 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA4 Gene

Proteomics data for IFNA4 Gene at MOPED

Post-translational modifications for IFNA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA4 Gene

Domains for IFNA4 Gene

Gene Families for IFNA4 Gene

  • IFN :Interferons

Suggested Antigen Peptide Sequences for IFNA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P05014
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA4: view

Function for IFNA4 Gene

Molecular function for IFNA4 Gene

GENATLAS Biochemistry: interferon type I,alpha 4,leukocyte
UniProtKB/Swiss-Prot Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Ontology (GO) - Molecular Function for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IFNA4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNA4 Gene

Localization for IFNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA4 Gene


Subcellular locations from

Jensen Localization Image for IFNA4 Gene COMPARTMENTS Subcellular localization image for IFNA4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA4: view

Pathways for IFNA4 Gene

genes like me logo Genes that share pathways with IFNA4: view

Gene Ontology (GO) - Biological Process for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA4: view

Transcripts for IFNA4 Gene

mRNA/cDNA for IFNA4 Gene

(11) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA4 Gene

No ASD Table

Relevant External Links for IFNA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA4 Gene

mRNA expression in normal human tissues for IFNA4 Gene

SOURCE GeneReport for Unigene cluster for IFNA4 Gene Hs.1510

genes like me logo Genes that share expressions with IFNA4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for IFNA4 Gene

Orthologs for IFNA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
IFNA17 35
  • 98.94 (n)
  • 97.35 (a)
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
-- 36
  • 63 (a)
-- 36
  • 64 (a)
-- 36
  • 63 (a)
-- 36
  • 62 (a)
  • 62 (a)
  • 63 (a)
  • 64 (a)
  • 63 (a)
  • 62 (a)
(Mus musculus)
Mammalia Gm12597 36
  • 62 (a)
Gm13280 36
  • 60 (a)
Ifna1 36
  • 61 (a)
Ifna11 36
  • 59 (a)
Ifna12 36
  • 61 (a)
Ifna13 36
  • 62 (a)
Ifna14 36
  • 59 (a)
Ifna2 36
  • 59 (a)
Ifna4 36
  • 58 (a)
Ifna5 36
  • 62 (a)
Ifna6 35
  • 76.04 (n)
  • 63.78 (a)
Ifna6 36
  • 62 (a)
Ifna7 36
  • 58 (a)
Ifna9 36
  • 60 (a)
Ifnab 36
  • 59 (a)
(Rattus norvegicus)
Mammalia Ifna2 35
  • 75.27 (n)
  • 62.37 (a)
Species with no ortholog for IFNA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA4 Gene

Gene Tree for IFNA4 (if available)
Gene Tree for IFNA4 (if available)

Paralogs for IFNA4 Gene

Selected SIMAP similar genes for IFNA4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA4: view

Variants for IFNA4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA4 Gene

Two forms exist; alpha-4a (shown here) and alpha-4b. They seem to be equally abundant

Sequence variations from dbSNP and Humsavar for IFNA4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1062562 -- 21,187,508(-) TTACT(G/T)ATGGC reference, synonymous-codon
rs1062571 - 21,187,312(-) AGAAG(A/G)CTCAA missense, reference
rs1062574 -- 21,187,116(-) GGACT(C/T)CATCC reference, missense
rs1062579 -- 21,186,944(-) CATGG(A/C)AATGA utr-variant-3-prime
rs1062584 -- 21,186,866(-) ACCAC(C/G)ACGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IFNA4 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294
esv2738274 CNV Deletion 23290073
esv2738275 CNV Deletion 23290073
dgv2297e1 CNV Complex 17122850

Relevant External Links for IFNA4 Gene

HapMap Linkage Disequilibrium report

Disorders for IFNA4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for IFNA4 Gene including...

Search for IFNA4 Gene in MalaCards »

Relevant External Links for IFNA4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IFNA4: view

No data available for UniProtKB/Swiss-Prot for IFNA4 Gene

Publications for IFNA4 Gene

  1. Structural relationship of human interferon alpha genes and pseudogenes. (PMID: 4057246) Henco K. … Weissmann C. (J. Mol. Biol. 1985) 3 4
  2. Nucleotide sequence and expression in E. coli of a human interferon- alpha gene selected from a genomic library using synthetic oligonucleotides. (PMID: 6089830) Linnane A.W. … Woodrow G.C. (Biochem. Int. 1984) 3 4
  3. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PMID: 9425112) Nyman T.A. … Kalkkinen N. (Biochem. J. 1998) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3

Products for IFNA4 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Common Cytokines in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat
    • Type I Interferon Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNA4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA4
    • Block miRNA regulation of IFNA4 using miScript Target Protectors

    Sources for IFNA4 Gene

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