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IFNA4 Gene

protein-coding   GIFtS: 54
GCID: GC09M021186

Interferon, Alpha 4

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Alpha 41 2     IFN-alpha-42 3
Interferon Alpha-4B2 3     IFN-alpha4a2
Interferon Alpha-762 3     INFA42
Interferon Alpha-M12 3     Interferon Alpha-42

External Ids:    HGNC: 54251   Entrez Gene: 34412   Ensembl: ENSG000002366377   OMIM: 1475645   UniProtKB: P050143   

Export aliases for IFNA4 gene to outside databases

Previous GC identifers: GC09M021514 GC09M021387 GC09M021176 GC09M021149


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IFNA4 Gene:
IFNA4 (interferon, alpha 4) is a protein-coding gene. Diseases associated with IFNA4 include hiv/aids, and dengue hemorrhagic fever. GO annotations related to this gene include type I interferon receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNA4_HUMAN, P05014
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFNA4 gene promoter:
         GR   Egr-2   Olf-1   IRF-7A   GR-alpha   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNA4 promoter sequence
   Search Chromatin IP Primers for IFNA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021186:  view genomic region     (about GC identifiers)

Start:
21,186,617 bp from pter      End:
21,187,598 bp from pter
Size:
982 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IFNA4_HUMAN, P05014 (See protein sequence)
Recommended Name: Interferon alpha-4 precursor  
Size: 189 amino acids; 21808 Da
Secondary accessions: P13358 Q14CS4 Q5VV15

Explore the universe of human proteins at neXtProt for IFNA4: NX_P05014

Explore proteomics data for IFNA4 at MOPED


See IFNA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_066546.1  
ENSEMBL proteins: 
 ENSP00000412897  
Reactome Protein details: P05014

IFNA4 Human Recombinant Protein Products:

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R&D Systems Recombinant & Natural Proteins for IFNA4 (IFN-alpha 4)
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OriGene Protein Over-expression Lysate for IFNA4
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Novus Biologicals IFNA4 Proteins
Novus Biologicals IFNA4 Lysates
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Sino Biological Cell Lysate for IFNA4
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IFNA4 Antibody Products:

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Novus Biologicals IFNA4 Antibodies
Abcam antibodies for IFNA4
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Search ThermoFisher Antibodies for IFNA4
LSBio Antibodies in human, mouse, rat for IFNA4

IFNA4 Assay Products:

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OriGene Custom Assay Services for IFNA4
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GenScript Custom Assay Services for IFNA4
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IFN: Interferons

4 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR015589 Interferon_alpha
 IPR000471 Interferon_alpha/beta/delta
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P05014

ProtoNet protein and cluster: P05014

1 Blocks protein domain: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNA4_HUMAN, P05014
Similarity: Belongs to the alpha/beta interferon family


IFNA4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IFNA4_HUMAN, P05014
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

     Genatlas biochemistry entry for IFNA4:
interferon type I,alpha 4,leukocyte

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IBA--
GO:0005126cytokine receptor binding ----
GO:0005132type I interferon receptor binding IBA--
     
IFNA4 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFNA4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFNA4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNA4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNA4

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidIFNA4 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for IFNA4
Predesigned siRNA for gene silencing in human, mouse, rat IFNA4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IFNA4

Clone
Products:
     
OriGene clones in human, mouse for IFNA4 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNA4 (NM_021068)
Sino Biological Human cDNA Clone for IFNA4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA4

Cell Line
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GenScript Custom overexpressing Cell Line Services for IFNA4
Browse ESI BIO Cell Lines and PureStem Progenitors for IFNA4 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IFNA4_HUMAN, P05014: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IBA--

IFNA4 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IFNA4 About   (see all 21)                                                                                              See pathways by source

SuperPathContained pathways About
1Toll-like receptor signaling pathway
Toll-like receptor signaling pathway0.94
Regulation of toll-like receptor signaling pathway0.93
Toll-like receptor signaling pathway0.94
Hepatitis B0.31
2Immune response IFN alpha beta signaling pathway
Immune response IFN alpha beta signaling pathway0.69
Interferon alpha/beta signaling0.43
Regulation of IFNA signaling0.69
3NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways0.58
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
NOD-like Receptor Signaling Pathways0.58
4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
TRAF6 mediated IRF7 activation0.40
RIG-I-like receptor signaling pathway0.47
5Influenza A
Influenza A0.34
Herpes simplex infection0.33
Measles0.34

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 R&D Systems Pathways for IFNA4
    NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways

4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IFNA4
    Cytokine Network
Interferon Pathway
JAK-STAT Pathway
all-trans-Retinoic Acid Mediated Apoptosis

2 GeneGo (Thomson Reuters) Pathways for IFNA4
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
Immune response IFN alpha/beta signaling pathway

2 BioSystems Pathways for IFNA4
    Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathway


4 Reactome Pathways for IFNA4
    Regulation of IFNA signaling
Interferon alpha/beta signaling
Factors involved in megakaryocyte development and platelet production
TRAF6 mediated IRF7 activation


Selected Kegg Pathways  (Kegg details for IFNA4) (see all 15):
    Cytokine-cytokine receptor interaction
Regulation of autophagy
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway


IFNA4 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNA4: 
          Interferons & Receptors in human mouse rat
          Type I Interferon Response in human mouse rat
          Common Cytokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for IFNA4

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for IFNA4 (ENSP000004128974) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IFNAR1ENSP000002701394STRING: ENSP00000270139
IFNAR2ENSP000003439574STRING: ENSP00000343957
IFNGR1ENSP000003567134STRING: ENSP00000356713
IFNGR2ENSP000002902194STRING: ENSP00000290219
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Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002250adaptive immune response IBA--
GO:0002286T cell activation involved in immune response IBA--
GO:0002323natural killer cell activation involved in immune response IBA--
GO:0006952defense response ----
GO:0006959humoral immune response IBA--

IFNA4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IFNA4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IFNA4 gene: 
NM_021068.2  

Unigene Cluster for IFNA4:

Interferon, alpha 4
Hs.1510
Unigene Representative Sequence: NM_021068
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000421715(uc003zon.2)
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat IFNA4 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate IFNA4
SwitchGear 3'UTR luciferase reporter plasmidIFNA4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for IFNA4
Predesigned siRNA for gene silencing in human, mouse, rat IFNA4
Clone
Products:
     
OriGene clones in human, mouse for IFNA4 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNA4 (NM_021068)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA4
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IFNA4
OriGene qSTAR qPCR primer pairs in human, mouse for IFNA4
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFNA4
  QuantiTect SYBR Green Assays in human, mouse, rat IFNA4
  QuantiFast Probe-based Assays in human, mouse, rat IFNA4

Additional mRNA sequence: 

BC074965.2 BC074966.2 BC113640.1 BC113642.1 M27318.1 

1 DOTS entry:

DT.121148358 

11 AceView cDNA sequences:

BC074965 BV199636 M27318 BV199635 BV199629 BC074966 NM_021068 BV199637 
BV199634 BV199642 BV199639 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IFNA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IFNA4 Expression
About this image

IFNA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IFNA4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.1510
    Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNA4: 
          Interferons & Receptors in human mouse rat
          Type I Interferon Response in human mouse rat
          Common Cytokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IFNA4
OriGene qSTAR qPCR primer pairs in human, mouse for IFNA4
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFNA4
QuantiTect SYBR Green Assays in human, mouse, rat IFNA4
QuantiFast Probe-based Assays in human, mouse, rat IFNA4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for IFNA4 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ifna61 interferon alpha 6 76.04(n)
63.78(a)
  15969  NM_206871.1  NP_996754.1 


ENSEMBL Gene Tree for IFNA4 (if available)
TreeFam Gene Tree for IFNA4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IFNA4 gene
IFNA72  IFNA22  IFNE2  IFNA142  IFNA52  IFNK2  IFNA12  IFNA212  
IFNA172  IFNA62  IFNB12  IFNA132  IFNW12  IFNA162  IFNA102  IFNA82  
18 SIMAP similar genes for IFNA4 using alignment to 1 protein entry:     IFNA4_HUMAN:
IFNA17    IFNA10    IFNA21    IFNA5    IFNA7    IFNA14
IFNA16    IFNA    IFN-2    IFNA2    IFNA2B    IFNA6
IFNA1    IFNA13    IFNA8    IFNW1    IFNB1    IFNE

IFNA4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot
IFNA4_HUMAN, P05014: Two forms exist; alpha-4a (shown here) and alpha-4b. They seem to be equally abundant


Selected SNPs for IFNA4 (see all 135)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1435003941,2
--21186117(+) CATGAC/GAGCCT 1 -- ds50010--------
rs1130383681,2
C,F--21186168(+) TATTGG/TATTCC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
rs1853847221,2
--21186208(+) TGCAAC/G/TGTACA 1 -- ds50010--------
rs1395658921,2
--21186212(+) ATGTAC/TATTTT 1 -- ds50010--------
rs122360481,2
C,F,A--21186254(+) TATCTG/CTGCTT 1 -- ds50012Minor allele frequency- C:0.16WA NA 238
rs1893154801,2
--21186325(+) CCTCAC/TATTAT 1 -- ds50010--------
rs579431571,2
C,F--21186423(+) GACTGT/AATATT 1 -- ds50011Minor allele frequency- A:0.50WA 2
rs562912831,2
C,F--21186424(+) ACTGTG/ATATTT 1 -- ds50011Minor allele frequency- A:0.50WA 2
rs1890223391,2
--21186520(+) GTAACA/TTAATT 1 -- ds50010--------
rs1811506951,2
--21186547(+) AGTCAA/GGTTGT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for IFNA4 (21186617 - 21187598 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for IFNA4:    About this table    
Variant IDTypeSubtypePubMed ID
esv2738274CNV Deletion23290073
esv2738275CNV Deletion23290073
nsv892735CNV Loss21882294
nsv892724CNV Gain21882294
nsv892734CNV Gain21882294
dgv2297e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IFNA4
DNA2.0 Custom Variant and Variant Library Synthesis for IFNA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147564    OMIM disorders: --

16 diseases for IFNA4:    About MalaCards
hiv/aids    dengue hemorrhagic fever    rabies    hemorrhagic fever
measles    autoimmune thyroiditis    hiv-1    herpes simplex
influenza    hepatitis c    hepatitis b    tuberculosis
multiple sclerosis    hepatitis    thyroiditis    melanoma


IFNA4 for disorders           About GeneDecksing

Genetic Association Database (GAD): IFNA4
Human Genome Epidemiology (HuGE) Navigator: IFNA4 (2 documents)

Export disorders for IFNA4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IFNA4 gene, integrated from 10 sources (see all 66):
(articles sorted by number of sources associating them with IFNA4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
  2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (Biochem. J. 1998)
  5. Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population. (PubMed id 9335434)1, 2 Hussain M.... Liao M.-J. (J. Interferon Cytokine Res. 1997)
  6. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (Genomics 1992)
  7. Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)1, 2 Henco K.... Weissmann C. (J. Mol. Biol. 1985)
  8. Nucleotide sequence and expression in E. coli of a human interferon- alpha gene selected from a genomic library using synthetic oligonucleotides. (PubMed id 6089830)1, 2 Linnane A.W.... Woodrow G.C. (Biochem. Int. 1984)
  9. Inhibitory effects of human immunodeficiency virus gp120 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cells. (PubMed id 22814248)1 Fang M....Yao H. (Acta Biochim. Biophys. Sin. (Shanghai) 2012)
  10. HIV-1 Gag-virus-like particles inhibit HIV-1 replication in dendritic cells and T cells through IFN-I+-dependent upregulation of APOBEC3G and 3F. (PubMed id 22739040)1 Chang M.O....Takaku H. (J Innate Immun 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3441 HGNC: 5425 AceView: IFNA4 Ensembl:ENSG00000236637 euGenes: HUgn3441
ECgene: IFNA4 Kegg: 3441 H-InvDB: IFNA4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IFNA4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IFNA4 gene:
Search GeneIP for patents involving IFNA4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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