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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNA21 Gene

protein-coding   GIFtS: 52
GCID: GC09M021165

interferon, alpha 21

 Explore 12 diseases affiliated with
IFNA21 via our new
 Human Malady Compendium 
Biological research products
for IFNA21
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interferon, Alpha 211 2     LeIF F2 3
IFN-AlphaI1     Interferon Alpha-212
Interferon Alpha-F2 3     LeIF-F1
IFN-Alpha-211     Leukocyte Interferon Protein2

External Ids:    HGNC: 54241   Entrez Gene: 34522   Ensembl: ENSG000001370807   OMIM: 1475845   UniProtKB: P015683   

Export aliases for IFNA21 gene to outside databases

Previous GC identifers: GC09M021493 GC09M021366 GC09M021155 GC09M021128


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNA21:
This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines
produced in response to viral infection that mediate the immune response and interfere with viral replication. The
encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus.
(provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two
enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA21


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFNA21 gene promoter:
         GR   Egr-3   GR-beta   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Egr-4   RORalpha1   S8   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNA21 promoter sequence
   Search SABiosciences Chromatin IP Primers for IFNA21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA21 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021165:  view genomic region     (about GC identifiers)

Start:
21,165,636 bp from pter      End:
21,166,659 bp from pter
Size:
1,024 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568 (See protein sequence)
Recommended Name: Interferon alpha-21 precursor  
Size: 189 amino acids; 21741 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAA36041.1; Type=Erroneous initiation;
Secondary accessions: Q14608 Q5VWD1 Q7M4Q4

Explore the universe of human proteins at neXtProt for IFNA21: NX_P01568

IFNA21 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_002166.2  
ENSEMBL proteins: 
 ENSP00000369574  
Reactome Protein details: P01568
Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IFNA21 (IFN-alpha F)
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OriGene Purified Protein: IFNA21
OriGene Protein Over-expression Lysate: IFNA21
OriGene Custom Protein Services for IFNA21 
GenScript Custom Purified and Recombinant Proteins Services for IFNA21
Novus Biologicals IFNA21 Proteins
Novus Biologicals IFNA21 Lysates
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--


IFNA21 for ontologies           About GeneDecksing



IFNA21 Antibody Products: 
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Novus Biologicals IFNA21 Antibodies
Search for Antibodies for IFNA21 at Abcam  
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Search ThermoFisher Antibodies for IFNA21

Assay Products for IFNA21: 
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GenScript Custom Assay Services for IFNA21
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFNA21 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR012351 4_helix_cytokine_core
 IPR015589 Interferon_alpha
 IPR000471 Interferon_alpha/beta/delta
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P01568

ProtoNet protein and cluster: P01568

1 Blocks protein family: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568
Similarity: Belongs to the alpha/beta interferon family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two
enzymes: a protein kinase and an oligoadenylate synthetase

     Genatlas biochemistry entry for IFNA21:
interferon type I,alpha 21,leukocyte

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA21
2 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNA21:
hsa-miR-186 hsa-miR-924
SwitchGear 3'UTR luciferase reporter plasmidIFNA21 3' UTR sequence
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNA21
OriGene shRNA RFP: IFNA21
OriGene siRNA: IFNA21
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA21

Gene Editing
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DNA2.0 Custom Protein Engineering Service for IFNA21

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA21
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: IFNA21 (NM_002175)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA21
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA21 

Cell Line
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Search LifeMap BioReagents cell lines for IFNA21

In Situ Assay
Products:
   

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFNA21

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005126cytokine receptor binding IEA--


IFNA21 for ontologies           About GeneDecksing



(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Regulation of IFNA signaling
Regulation of IFNA signaling1.00
TRAF6 mediated IRF7 activation0.33
Immune response_IFN alpha/beta signaling pathway0.71
Cytokine Network0.28
Immune response IFN alpha/beta signaling pathway0.71
Regulation of autophagy0.26
Expression of Interferon-alpha and beta0.52
2Toll-like receptor signaling pathway
Toll-like receptor signaling pathway1.00
Toll-Like receptor Signaling Pathways0.51
Toll-like receptor signaling pathway0.97
3Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway
Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway1.00
Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
4Cytokine Signaling in Immune system
Cytokine Signaling in Immune system1.00
Interferon Signaling0.61
5Immune System
Immune System1.00
Innate Immune System0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IFNA21
    Immune response IFN alpha/beta signaling pathway
Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

1 R&D Systems Pathway for IFNA21
    Toll-Like receptor Signaling Pathways

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA21
    Cytokine Network
Interferon Pathway
JAK-STAT Pathway
all-trans-Retinoic Acid Mediated Apoptosis

2 GeneGo (Thomson Reuters) Pathways for IFNA21
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
Immune response IFN alpha/beta signaling pathway

1 BioSystems Pathway for IFNA21 
    Toll-like receptor signaling pathway

5/11        Reactome Pathways for IFNA21 (see all 11)
    Hemostasis
Regulation of IFNA signaling
Interferon alpha/beta signaling
Cytokine Signaling in Immune system
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways


5/12         Kegg Pathways  (Kegg details for IFNA21) (see all 12):
    Cytokine-cytokine receptor interaction
Regulation of autophagy
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway


IFNA21 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA21

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for IFNA21 (ENSP000003695744) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IFNAR1ENSP000002701394STRING: ENSP00000270139
IFNAR2ENSP000003439574STRING: ENSP00000343957
IFNGR1ENSP000003567134STRING: ENSP00000356713
IFNGR2ENSP000002902194STRING: ENSP00000290219
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007596blood coagulation TAS--
GO:0009615response to virus ----
GO:0019221cytokine-mediated signaling pathway TAS--
GO:0045087innate immune response TAS--
GO:0051607defense response to virus IEA--


IFNA21 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNA21
Search CenterWatch for drugs/clinical trials and news about IFNA21 / IFN21 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNA21 gene: 
NM_002175.2  

Unigene Cluster for IFNA21:

Interferon, alpha 21
Hs.113211
Unigene Representative Sequence: NM_002175
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000380225(uc003zom.2)

miRNA
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2 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNA21:
hsa-miR-186 hsa-miR-924
SwitchGear 3'UTR luciferase reporter plasmidIFNA21 3' UTR sequence
Inhib. RNA
Products:
     
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OriGene shRNA RFP: IFNA21
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA21
Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA21
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: IFNA21 (NM_002175)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA21
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA21 
Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA21
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFNA21
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA21
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA21

Additional cDNA sequence: 

BC069329.1 BC069372.1 BC069408.1 BC096699.1 BC101638.1 BC101640.1 M12350.1 M28586.1 
V00540.1 X00145.1 

1 DOTS entry:

DT.108640 

11 AceView cDNA sequences:

BC069408 M28586 BC069372 BC069329 X00145 M12350 V00540 BV199632 
NM_002175 BV199628 BV199630 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNA21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATATTATG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See IFNA21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA21

SOURCE GeneReport for Unigene cluster: Hs.113211
    SABiosciences Expression via Pathway-Focused PCR Array including IFNA21: 
          Interferons & Receptors in human mouse rat

Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA21
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA21
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA21
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFNA21

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFNA21 gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
--
32(a)
1 → many
Un(24396419-24396970)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 6)
--
27(a)
26(a)
(see all 6)
many ↔ many
many ↔ many
(see all 6)
2(61647787-61648344)
2(61644933-61645472)
zebrafish
(Danio rerio)
Actinopterygii ifnphi36
ifnphi26
interferon phi 2
24(a)
22(a)
many ↔ many
many ↔ many
3(22558521-22560658)
3(22565711-22572180)


ENSEMBL Gene Tree for IFNA21 (if available)
TreeFam Gene Tree for IFNA21 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IFNA21 gene
IFNA72  IFNA22  IFNE2  IFNA42  IFNA142  IFNK2  IFNA52  IFNA12  
IFNA172  IFNA62  IFNB12  IFNA132  IFNW12  IFNA162  IFNA102  IFNA82  
18 SIMAP similar genes for IFNA21 using alignment to 1 protein entry:     IFN21_HUMAN:
IFNA10    IFNA17    IFNA4    IFNA5    IFNA7    IFN-2
IFNA    IFNA14    IFNA16    IFNA1    IFNA13    IFNA6
IFNA8    IFNA2    IFNA2B    IFNW1    IFNB1    IFNE

IFNA21 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for IFNA21
PGOHUM00000236405


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/119 NCBI SNPs in IFNA21 are shown (see all 119    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs344511751,2
F,--21128809(-) TATTCT/CTTAAT 1 -- ut311Minor allele frequency- C:0.02NA 120
rs10538851,2
H--21129408(-) ATGACC/ATGGAA 2 /M /L mis16Minor allele frequency- A:0.00NS EA NA 408
rs10538841,2
C,F,--21129574(-) CCCCAG/AGAGGA 2 /Q syn1 ese32Minor allele frequency- A:0.01NS NA 4614
rs101199421,2
C,--21129800(+) GATGGG/ATAACC 1 -- ut512Minor allele frequency- A:0.00NA 4
rs169383051,2
C,F,,--21129813(+) GAACCT/GTGGCC 1 -- us2k13Minor allele frequency- G:0.01NA 140
rs1127385001,2
--21129934(+) TTATGC/TACTCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
rs726898731,2
C,--21130785(+) GTTTAC/TCTTCA 1 -- us2k10--------
rs44154001,2
H,--21131608(+) CATATC/ATGAAT 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
rs70210361,2
C,F,A,H,--21131633(+) TCACAC/TGGTTT 1 -- us2k14Minor allele frequency- T:0.01NS EA 416
rs70210651,2
C,F,A,--21131744(+) TGTGTA/GTGTGA 1 -- us2k15Minor allele frequency- G:0.01NA 146

HapMap Linkage Disequilibrium report for IFNA21 (21165636 - 21166659 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for IFNA21: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA21
DNA2.0 Custom Variant and Variant Library Synthesis for IFNA21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IFNA21 for disorders           About GeneDecksing

OMIM gene information: 147584    OMIM disorders: --

12 diseases for IFNA21:    About MalaCards
rubella    dengue hemorrhagic fever    hemorrhagic fever    autoimmune thyroiditis
hepatitis c    hepatitis b    measles    hepatitis
influenza    thyroiditis    tuberculosis    melanoma

2 diseases from the University of Copenhagen DISEASES database for IFNA21:
Hepatitis C     Hepatitis B
Human Genome Epidemiology (HuGE) Navigator: IFNA21 (5 documents)

Export disorders for IFNA21 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IFNA21 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with IFNA21)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (1998)
  3. Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (PubMed id 8910771)1, 2 Hussain M.... Liao M.-J. (1996)
  4. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
  5. Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes. (PubMed id 6548765)1, 2 Gren E....Apsalons U. (1984)
  6. The structure of eight distinct cloned human leukocyte interferon cDNAs. (PubMed id 6163083)1, 2 Goeddel D.V.... Gray P.W. (1981)
  7. Inhibitory effects of human immunodeficiency virus gp1 20 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cel ls. (PubMed id 22814248)1 Fang M....Yao H. (2012)
  8. HIV-1 Gag-virus-like particles inhibit HIV-1 replicati on in dendritic cells and T cells through IFN-a-dependent upregulation of APOBEC 3G and 3F. (PubMed id 22739040)1 Chang M.O....Takaku H. (2012)
  9. Role of retroviral restriction factors in the interfer on-a-mediated suppression of HIV-1 in vivo. (PubMed id 22315404)1 Pillai S.K....Wong J.K. (2012)
  10. Structural variants of IFNI+ preferentially promote an tiviral functions. (PubMed id 21757613)1 VA!zquez N....Wahl S.M. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3452 HGNC: 5424 AceView: IFNA21 Ensembl:ENSG00000137080 euGenes: HUgn3452
ECgene: IFNA21 Kegg: 3452 H-InvDB: IFNA21

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IFNA21 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IFNA21 gene:
Search GeneIP for patents involving IFNA21

GeneCards and IP:
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