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Aliases for IFNA21 Gene

Aliases for IFNA21 Gene

  • Interferon, Alpha 21 2 3
  • Leukocyte Interferon Protein 2 3
  • Interferon Alpha-F 3 4
  • IFN-Alpha-21 3 4
  • LeIF F 3 4
  • Interferon Alpha-21 3
  • IFN-AlphaI 3
  • LeIF-F 3

External Ids for IFNA21 Gene

Summaries for IFNA21 Gene

Entrez Gene Summary for IFNA21 Gene

  • This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]

GeneCards Summary for IFNA21 Gene

IFNA21 (Interferon, Alpha 21) is a Protein Coding gene. Diseases associated with IFNA21 include hiv-1. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and cytokine receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA21 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA21 Gene

Genomics for IFNA21 Gene

Genomic Location for IFNA21 Gene

Start:
21,165,637 bp from pter
End:
21,166,660 bp from pter
Size:
1,024 bases
Orientation:
Minus strand

Genomic View for IFNA21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNA21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA21 Gene

Regulatory Elements for IFNA21 Gene

Proteins for IFNA21 Gene

  • Protein details for IFNA21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01568-IFN21_HUMAN
    Recommended name:
    Interferon alpha-21
    Protein Accession:
    P01568
    Secondary Accessions:
    • Q14608
    • Q5VWD1
    • Q7M4Q4

    Protein attributes for IFNA21 Gene

    Size:
    189 amino acids
    Molecular mass:
    21741 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36041.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IFNA21 Gene

Proteomics data for IFNA21 Gene at MOPED

Post-translational modifications for IFNA21 Gene

No Post-translational modifications

Other Protein References for IFNA21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA21 Gene

Domains for IFNA21 Gene

Gene Families for IFNA21 Gene

HGNC:
  • IFN :Interferons

UniProtKB/Swiss-Prot:

IFN21_HUMAN
Family:
  • Belongs to the alpha/beta interferon family.:
    • P01568
genes like me logo Genes that share domains with IFNA21: view

Function for IFNA21 Gene

Molecular function for IFNA21 Gene

GENATLAS Biochemistry: interferon type I,alpha 21,leukocyte
UniProtKB/Swiss-Prot Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA21: view

miRNA for IFNA21 Gene

miRTarBase miRNAs that target IFNA21

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IFNA21 Gene

Localization for IFNA21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA21 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA21 Gene COMPARTMENTS Subcellular localization image for IFNA21 gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for IFNA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA21: view

Pathways for IFNA21 Gene

genes like me logo Genes that share pathways with IFNA21: view

Gene Ontology (GO) - Biological Process for IFNA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA21: view

Transcripts for IFNA21 Gene

mRNA/cDNA for IFNA21 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNA21 Gene

Interferon, alpha 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA21 Gene

No ASD Table

Relevant External Links for IFNA21 Gene

GeneLoc Exon Structure for
IFNA21
ECgene alternative splicing isoforms for
IFNA21

Expression for IFNA21 Gene

mRNA expression in normal human tissues for IFNA21 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA21 Gene

This gene is overexpressed in Brain - Cerebellum (6.0), Brain - Cerebellar Hemisphere (5.6), and Brain - Frontal Cortex (BA9) (4.2).

SOURCE GeneReport for Unigene cluster for IFNA21 Gene Hs.113211

genes like me logo Genes that share expressions with IFNA21: view

Orthologs for IFNA21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA21 36
  • 100 (n)
  • 100 (a)
IFNA21 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 62 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 61 (a)
ManyToMany
IFNAA 37
  • 60 (a)
ManyToMany
IFNAG 37
  • 62 (a)
ManyToMany
IFNAG 37
  • 62 (a)
ManyToMany
IFNAH 37
  • 62 (a)
ManyToMany
INFAF 37
  • 61 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 37
  • 61 (a)
ManyToMany
Gm13280 37
  • 59 (a)
ManyToMany
Ifna1 37
  • 60 (a)
ManyToMany
Ifna11 37
  • 57 (a)
ManyToMany
Ifna12 37
  • 61 (a)
ManyToMany
Ifna13 37
  • 60 (a)
ManyToMany
Ifna14 37
  • 58 (a)
ManyToMany
Ifna2 37
  • 57 (a)
ManyToMany
Ifna4 37
  • 56 (a)
ManyToMany
Ifna5 37
  • 61 (a)
ManyToMany
Ifna6 37
  • 61 (a)
ManyToMany
Ifna7 37
  • 57 (a)
ManyToMany
Ifna9 37
  • 59 (a)
ManyToMany
Ifnab 37
  • 58 (a)
ManyToMany
Species with no ortholog for IFNA21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA21 Gene

ENSEMBL:
Gene Tree for IFNA21 (if available)
TreeFam:
Gene Tree for IFNA21 (if available)

Paralogs for IFNA21 Gene

Selected SIMAP similar genes for IFNA21 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFNA21 Gene

genes like me logo Genes that share paralogs with IFNA21: view

Variants for IFNA21 Gene

Sequence variations from dbSNP and Humsavar for IFNA21 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2939 -- 21,166,005(-) ACTAA(C/T)ACACC utr-variant-3-prime
rs1053884 -- 21,166,424(-) CCCCA(A/G)GAGGA synonymous-codon, reference
rs1053885 - 21,166,258(-) ATGAC(A/C)TGGAA missense, reference
rs1053886 -- 21,166,192(-) CCATC(C/T)TGGCT reference, synonymous-codon
rs1053887 -- 21,166,124(-) TGTGC(C/T)TGGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IFNA21 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294

Relevant External Links for IFNA21 Gene

HapMap Linkage Disequilibrium report
IFNA21

Disorders for IFNA21 Gene

(1) MalaCards Diseases for IFNA21 Gene

Search for IFNA21 Gene in MalaCards »

(3) University of Copenhagen DISEASES for IFNA21 Gene

Relevant External Links for IFNA21

Genetic Association Database (GAD)
IFNA21
Human Genome Epidemiology (HuGE) Navigator
IFNA21
genes like me logo Genes that share disorders with IFNA21: view

No data available for UniProtKB/Swiss-Prot for IFNA21 Gene

Publications for IFNA21 Gene

  1. The structure of eight distinct cloned human leukocyte interferon cDNAs. (PMID: 6163083) Goeddel D.V. … Gray P.W. (Nature 1981) 3 4
  2. Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes. (PMID: 6548765) Gren E. … Apsalons U. (J. Interferon Res. 1984) 3 4
  3. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  4. Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (PMID: 8910771) Hussain M. … Liao M.-J. (J. Interferon Cytokine Res. 1996) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for IFNA21 Gene

  • antibodies-online proteins for IFNA21
  • antibodies-online antibodies for IFNA21
  • antibodies-online kits for IFNA21

Sources for IFNA21 Gene

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