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Aliases for IFNA21 Gene

Aliases for IFNA21 Gene

  • Interferon, Alpha 21 2 3 5
  • Leukocyte Interferon Protein 2 3
  • Interferon Alpha-F 3 4
  • IFN-Alpha-21 3 4
  • LeIF F 3 4
  • IFN-AlphaI 3
  • LeIF-F 3

External Ids for IFNA21 Gene

Previous GeneCards Identifiers for IFNA21 Gene

  • GC09M021493
  • GC09M021366
  • GC09M021155
  • GC09M021128

Summaries for IFNA21 Gene

Entrez Gene Summary for IFNA21 Gene

  • This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]

GeneCards Summary for IFNA21 Gene

IFNA21 (Interferon, Alpha 21) is a Protein Coding gene. Diseases associated with IFNA21 include Rubella. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Allograft rejection. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA21 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA21 Gene

Genomics for IFNA21 Gene

Regulatory Elements for IFNA21 Gene

Enhancers for IFNA21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFNA21 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNA21 Gene

21,165,637 bp from pter
21,166,660 bp from pter
1,024 bases
Minus strand

Genomic View for IFNA21 Gene

Genes around IFNA21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA21 Gene

Proteins for IFNA21 Gene

  • Protein details for IFNA21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-21
    Protein Accession:
    Secondary Accessions:
    • Q14608
    • Q5VWD1
    • Q7M4Q4

    Protein attributes for IFNA21 Gene

    189 amino acids
    Molecular mass:
    21741 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA36041.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IFNA21 Gene

Proteomics data for IFNA21 Gene at MOPED

Post-translational modifications for IFNA21 Gene

No Post-translational modifications

Other Protein References for IFNA21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA21 Gene

Domains & Families for IFNA21 Gene

Gene Families for IFNA21 Gene

Suggested Antigen Peptide Sequences for IFNA21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA21: view

Function for IFNA21 Gene

Molecular function for IFNA21 Gene

GENATLAS Biochemistry:
interferon type I,alpha 21,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
genes like me logo Genes that share phenotypes with IFNA21: view

Animal Model Products

miRNA for IFNA21 Gene

miRTarBase miRNAs that target IFNA21

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFNA21 Gene

Localization for IFNA21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA21 Gene


Subcellular locations from

Jensen Localization Image for IFNA21 Gene COMPARTMENTS Subcellular localization image for IFNA21 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for IFNA21 Gene

Pathways & Interactions for IFNA21 Gene

genes like me logo Genes that share pathways with IFNA21: view

Gene Ontology (GO) - Biological Process for IFNA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
GO:0007596 blood coagulation TAS --
GO:0019221 cytokine-mediated signaling pathway IBA,TAS --
genes like me logo Genes that share ontologies with IFNA21: view

No data available for SIGNOR curated interactions for IFNA21 Gene

Drugs & Compounds for IFNA21 Gene

No Compound Related Data Available

Transcripts for IFNA21 Gene

mRNA/cDNA for IFNA21 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNA21 Gene

Interferon, alpha 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA21 Gene

No ASD Table

Relevant External Links for IFNA21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA21 Gene

mRNA expression in normal human tissues for IFNA21 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA21 Gene

This gene is overexpressed in Brain - Cerebellum (x6.0), Brain - Cerebellar Hemisphere (x5.6), and Brain - Frontal Cortex (BA9) (x4.2).

SOURCE GeneReport for Unigene cluster for IFNA21 Gene Hs.113211

genes like me logo Genes that share expression patterns with IFNA21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFNA21 Gene

Orthologs for IFNA21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNA21 35
  • 100 (n)
  • 100 (a)
IFNA21 36
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
-- 36
  • 62 (a)
-- 36
  • 62 (a)
-- 36
  • 62 (a)
-- 36
  • 61 (a)
  • 60 (a)
  • 62 (a)
  • 62 (a)
  • 62 (a)
  • 61 (a)
(Mus musculus)
Mammalia Gm12597 36
  • 61 (a)
Gm13280 36
  • 59 (a)
Ifna1 36
  • 60 (a)
Ifna11 36
  • 57 (a)
Ifna12 36
  • 61 (a)
Ifna13 36
  • 60 (a)
Ifna14 36
  • 58 (a)
Ifna2 36
  • 57 (a)
Ifna4 36
  • 56 (a)
Ifna5 36
  • 61 (a)
Ifna6 36
  • 61 (a)
Ifna7 36
  • 57 (a)
Ifna9 36
  • 59 (a)
Ifnab 36
  • 58 (a)
Species with no ortholog for IFNA21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA21 Gene

Gene Tree for IFNA21 (if available)
Gene Tree for IFNA21 (if available)

Paralogs for IFNA21 Gene

(18) SIMAP similar genes for IFNA21 Gene using alignment to 1 proteins: Pseudogenes for IFNA21 Gene

genes like me logo Genes that share paralogs with IFNA21: view

Variants for IFNA21 Gene

Sequence variations from dbSNP and Humsavar for IFNA21 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3750478 - 21,166,078(+) AATTT(C/T)TGATA reference, missense
rs1053885 - 21,166,258(-) ATGAC(A/C)TGGAA reference, missense
rs1053884 -- 21,166,424(-) CCCCA(A/G)GAGGA reference, synonymous-codon
rs1053886 -- 21,166,192(-) CCATC(C/T)TGGCT reference, synonymous-codon
rs1053887 -- 21,166,124(-) TGTGC(C/T)TGGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IFNA21 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294

Variation tolerance for IFNA21 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IFNA21 Gene

Disorders for IFNA21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNA21 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • german measles
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IFNA21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IFNA21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA21 Gene

Publications for IFNA21 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 48 67
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  3. HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms. (PMID: 25972534) Reszka-Blanco N.J. … Su L. (J. Virol. 2015) 3
  4. Evidence for a different susceptibility of primate lentiviruses to type I interferons. (PMID: 23255800) Cordeil S. … Cimarelli A. (J. Virol. 2013) 3
  5. Role of retroviral restriction factors in the interferon-I+-mediated suppression of HIV-1 in vivo. (PMID: 22315404) Pillai S.K. … Wong J.K. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3

Products for IFNA21 Gene

Sources for IFNA21 Gene