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IFNA21 Gene

protein-coding   GIFtS: 57
GCID: GC09M021165

Interferon, Alpha 21

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Alpha 211 2     LeIF F2 3
Leukocyte Interferon Protein1 2     IFN-alphaI2
Interferon Alpha-F2 3     Interferon Alpha-212
IFN-alpha-212 3     leIF-F2

External Ids:    HGNC: 54241   Entrez Gene: 34522   Ensembl: ENSG000001370807   OMIM: 1475845   UniProtKB: P015683   

Export aliases for IFNA21 gene to outside databases

Previous GC identifers: GC09M021493 GC09M021366 GC09M021155 GC09M021128


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFNA21 Gene:
This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are
cytokines produced in response to viral infection that mediate the immune response and interfere with viral
replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to
rubella virus. (provided by RefSeq, Sep 2011)

GeneCards Summary for IFNA21 Gene:
IFNA21 (interferon, alpha 21) is a protein-coding gene. Diseases associated with IFNA21 include rubella, and hiv/aids. GO annotations related to this gene include cytokine receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFNA21 gene promoter:
         GR   Egr-3   GR-beta   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Egr-4   RORalpha1   S8   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNA21 promoter sequence
   Search Chromatin IP Primers for IFNA21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNA21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA21 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021165:  view genomic region     (about GC identifiers)

Start:
21,165,636 bp from pter      End:
21,166,659 bp from pter
Size:
1,024 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568 (See protein sequence)
Recommended Name: Interferon alpha-21 precursor  
Size: 189 amino acids; 21741 Da
Sequence caution: Sequence=AAA36041.1; Type=Erroneous initiation;
Secondary accessions: Q14608 Q5VWD1 Q7M4Q4

Explore the universe of human proteins at neXtProt for IFNA21: NX_P01568

Explore proteomics data for IFNA21 at MOPED


See IFNA21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002166.2  
ENSEMBL proteins: 
 ENSP00000369574  
Reactome Protein details: P01568

IFNA21 Human Recombinant Protein Products:

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R&D Systems Recombinant & Natural Proteins for IFNA21 (IFN-alpha F)
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OriGene Protein Over-expression Lysate for IFNA21
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Novus Biologicals IFNA21 Proteins
Novus Biologicals IFNA21 Lysates
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Browse Sino Biological Cell Lysates
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Browse Proteins at Cloud-Clone Corp.

IFNA21 Antibody Products:

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OriGene Custom Antibody Services for IFNA21
Novus Biologicals IFNA21 Antibodies
Abcam antibodies for IFNA21
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ThermoFisher Antibody for IFNA21
LSBio Antibodies in human, mouse, rat for IFNA21

IFNA21 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IFNA21
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for IFNA21
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IFN: Interferons

4 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR015589 Interferon_alpha
 IPR000471 Interferon_alpha/beta/delta
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P01568

ProtoNet protein and cluster: P01568

1 Blocks protein domain: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568
Similarity: Belongs to the alpha/beta interferon family


IFNA21 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IFN21_HUMAN, P01568
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

     Genatlas biochemistry entry for IFNA21:
interferon type I,alpha 21,leukocyte

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IBA--
GO:0005126cytokine receptor binding TAS6163083
GO:0005132type I interferon receptor binding IBA--
     
IFNA21 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFNA21
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFNA21

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNA21
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNA21

miRNA
Products:
    
miRTarBase miRNAs that target IFNA21:
hsa-mir-335-5p (MIRT016701)

Block miRNA regulation of human, mouse, rat IFNA21 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate IFNA21:
hsa-miR-186 hsa-miR-924
SwitchGear 3'UTR luciferase reporter plasmidIFNA21 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for IFNA21
Predesigned siRNA for gene silencing in human, mouse, rat IFNA21

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IFNA21

Clone
Products:
     
OriGene clones in human, mouse for IFNA21 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNA21 (NM_002175)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA21
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA21

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IFNA21
Browse ESI BIO Cell Lines and PureStem Progenitors for IFNA21 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA21


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IFN21_HUMAN, P01568: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IBA--

IFNA21 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IFNA21 About   (see all 21)  
See pathways by source

SuperPathContained pathways About
1Toll-like receptor signaling pathway
Toll-like receptor signaling pathway0.94
Regulation of toll-like receptor signaling pathway0.93
Toll-like receptor signaling pathway0.94
Hepatitis B0.31
2Immune response IFN alpha beta signaling pathway
Immune response IFN alpha beta signaling pathway0.69
Interferon alpha/beta signaling0.43
Regulation of IFNA signaling0.69
3NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways0.58
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
NOD-like Receptor Signaling Pathways0.58
4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
TRAF6 mediated IRF7 activation0.40
RIG-I-like receptor signaling pathway0.47
5Influenza A
Influenza A0.34
Herpes simplex infection0.33
Measles0.34

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 R&D Systems Pathways for IFNA21
    NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways

4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IFNA21
    Cytokine Network
Interferon Pathway
JAK-STAT Pathway
all-trans-Retinoic Acid Mediated Apoptosis

2 GeneGo (Thomson Reuters) Pathways for IFNA21
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
Immune response IFN alpha/beta signaling pathway

2 BioSystems Pathways for IFNA21
    Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathway

4 Reactome Pathways for IFNA21
    Regulation of IFNA signaling
Interferon alpha/beta signaling
Factors involved in megakaryocyte development and platelet production
TRAF6 mediated IRF7 activation


Selected Kegg Pathways  (Kegg details for IFNA21) (see all 15):
    Cytokine-cytokine receptor interaction
Regulation of autophagy
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway


IFNA21 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including IFNA21: 
          Interferons & Receptors in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for IFNA21

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for IFNA21 (ENSP000003695744) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IFNAR1ENSP000002701394STRING: ENSP00000270139
IFNAR2ENSP000003439574STRING: ENSP00000343957
IFNGR1ENSP000003567134STRING: ENSP00000356713
IFNGR2ENSP000002902194STRING: ENSP00000290219
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Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002250adaptive immune response IBA--
GO:0002286T cell activation involved in immune response IBA--
GO:0002323natural killer cell activation involved in immune response IBA--
GO:0006952defense response ----
GO:0006959humoral immune response IBA--

IFNA21 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IFNA21 (IFN21)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IFNA21 gene: 
NM_002175.2  

Unigene Cluster for IFNA21:

Interferon, alpha 21
Hs.113211
Unigene Representative Sequence: NM_002175
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000380225(uc003zom.2)
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat IFNA21 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate IFNA21:
hsa-miR-186 hsa-miR-924
SwitchGear 3'UTR luciferase reporter plasmidIFNA21 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for IFNA21
Predesigned siRNA for gene silencing in human, mouse, rat IFNA21
Clone
Products:
     
OriGene clones in human, mouse for IFNA21 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNA21 (NM_002175)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA21
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA21
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for IFNA21
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFNA21
  QuantiTect SYBR Green Assays in human, mouse, rat IFNA21
  QuantiFast Probe-based Assays in human, mouse, rat IFNA21

Additional mRNA sequence: 

BC069329.1 BC069372.1 BC069408.1 BC096699.1 BC101638.1 BC101640.1 M12350.1 M28586.1 
V00540.1 X00145.1 

1 DOTS entry:

DT.108640 

11 AceView cDNA sequences:

BC069408 M12350 BC069372 BC069329 M28586 X00145 V00540 BV199632 
BV199628 NM_002175 BV199630 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IFNA21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAATATTATG
IFNA21 Expression
About this image

IFNA21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IFNA21 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.113211
    Pathway & Disease-focused RT2 Profiler PCR Array including IFNA21: 
          Interferons & Receptors in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for IFNA21
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFNA21
QuantiTect SYBR Green Assays in human, mouse, rat IFNA21
QuantiFast Probe-based Assays in human, mouse, rat IFNA21
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA21

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for IFNA21 (if available)
TreeFam Gene Tree for IFNA21 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IFNA21 gene
IFNA72  IFNA22  IFNA42  IFNE2  IFNA142  IFNA52  IFNK2  IFNA12  
IFNA172  IFNA62  IFNB12  IFNA132  IFNW12  IFNA162  IFNA102  IFNA82  
18 SIMAP similar genes for IFNA21 using alignment to 1 protein entry:     IFN21_HUMAN:
IFNA10    IFNA17    IFNA4    IFNA5    IFNA7    IFN-2
IFNA    IFNA14    IFNA16    IFNA1    IFNA13    IFNA6
IFNA8    IFNA2    IFNA2B    IFNW1    IFNB1    IFNE

IFNA21 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for IFNA21
PGOHUM00000236405


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IFNA21 (see all 141)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1435486421,2
--21159852(+) TGGCTC/TTTCTC 1 -- ds50010--------
rs1882855401,2
--21160001(+) ATGGAC/GACTTG 1 -- ds50010--------
rs70388521,2
C,F,A,H--21160028(+) TGTCTA/GCTATA 1 -- ds500121Minor allele frequency- G:0.31NS EA NA WA CSA 2348
rs70241351,2
C,F,A,H--21160054(+) TTTTTA/TAAAAA 1 -- ds50017Minor allele frequency- T:0.33NA WA EA 366
rs1467815881,2
--21160124(+) CTATAA/GCATTT 1 -- ds50010--------
rs1931762001,2
--21160173(+) TTACAA/GAAATA 1 -- ds50010--------
rs1489358271,2
--21160194(+) GAAAGC/TGAAAA 1 -- ds50010--------
rs1151833741,2
C--21160250(+) CCTCGC/GTTAGA 1 -- ds50010--------
rs1437091661,2
--21160267(+) CAATTA/TTTACT 1 -- ds50010--------
rs344511751,2
C,F--21160364(-) TATTCT/CTTAAT 1 -- ut311Minor allele frequency- C:0.02NA 120

HapMap Linkage Disequilibrium report for IFNA21 (21165636 - 21166659 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for IFNA21:    About this table    
Variant IDTypeSubtypePubMed ID
nsv892735CNV Loss21882294
nsv892724CNV Gain21882294
nsv892734CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IFNA21
DNA2.0 Custom Variant and Variant Library Synthesis for IFNA21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147584    OMIM disorders: --

18 diseases for IFNA21:    
About MalaCards
rubella    hiv/aids    dengue hemorrhagic fever    hemorrhagic fever
measles    narcolepsy    autoimmune thyroiditis    hiv-1
cutaneous malignant melanoma    hepatitis c virus    influenza    hepatitis c
hepatitis b    tuberculosis    hepatitis    thyroiditis
herpes simplex    melanoma

3 diseases from the University of Copenhagen DISEASES database for IFNA21:
Hepatitis C     Hepatitis B     Melanoma

IFNA21 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Genetic Association Database (GAD): IFNA21
Human Genome Epidemiology (HuGE) Navigator: IFNA21 (5 documents)

Export disorders for IFNA21 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IFNA21 gene, integrated from 10 sources (see all 67):
(articles sorted by number of sources associating them with IFNA21)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (Fam. Cancer 2010)
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (Biochem. J. 1998)
  7. Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (PubMed id 8910771)1, 2 Hussain M.... Liao M.-J. (J. Interferon Cytokine Res. 1996)
  8. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (Genomics 1992)
  9. Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes. (PubMed id 6548765)1, 2 Gren E....Apsalons U. (J. Interferon Res. 1984)
  10. The structure of eight distinct cloned human leukocyte interferon cDNAs. (PubMed id 6163083)1, 2 Goeddel D.V.... Gray P.W. (Nature 1981)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3452 HGNC: 5424 AceView: IFNA21 Ensembl:ENSG00000137080 euGenes: HUgn3452
ECgene: IFNA21 Kegg: 3452 H-InvDB: IFNA21

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IFNA21 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IFNA21 gene:
Search GeneIP for patents involving IFNA21

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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