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Aliases for IFNA21 Gene

Aliases for IFNA21 Gene

  • Interferon Alpha 21 2 3 5
  • Leukocyte Interferon Protein 2 3
  • Interferon Alpha-F 3 4
  • IFN-Alpha-21 3 4
  • LeIF F 3 4
  • Interferon Alpha-21 3
  • IFN-AlphaI 3
  • LeIF-F 3

External Ids for IFNA21 Gene

Previous GeneCards Identifiers for IFNA21 Gene

  • GC09M021493
  • GC09M021366
  • GC09M021155
  • GC09M021128

Summaries for IFNA21 Gene

Entrez Gene Summary for IFNA21 Gene

  • This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]

GeneCards Summary for IFNA21 Gene

IFNA21 (Interferon Alpha 21) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA4.

UniProtKB/Swiss-Prot for IFNA21 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA21 Gene

Additional gene information for IFNA21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA21 Gene

Genomics for IFNA21 Gene

GeneHancer (GH) Regulatory Elements for IFNA21 Gene

Promoters and enhancers for IFNA21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I020821 Enhancer 0.2 FANTOM5 6.3 +344.8 344815 0.3 IFNA5 IFNA21 SNORA30B FOCAD LOC105375989
GH09I021160 Enhancer 0.8 Ensembl ENCODE 0.4 +6.3 6314 0.3 CBFB JUN BATF IKZF1 ETV6 RUNX3 IKZF2 SPI1 ENSG00000199635 GC09M021161 IFNA21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFNA21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNA21 gene promoter:

Genomic Locations for IFNA21 Gene

Genomic Locations for IFNA21 Gene
1,024 bases
Minus strand

Genomic View for IFNA21 Gene

Genes around IFNA21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA21 Gene

Proteins for IFNA21 Gene

  • Protein details for IFNA21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-21
    Protein Accession:
    Secondary Accessions:
    • Q14608
    • Q5VWD1
    • Q7M4Q4

    Protein attributes for IFNA21 Gene

    189 amino acids
    Molecular mass:
    21741 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA36041.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IFNA21 Gene

Post-translational modifications for IFNA21 Gene

No Post-translational modifications

Other Protein References for IFNA21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA21 Gene

Domains & Families for IFNA21 Gene

Gene Families for IFNA21 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IFNA21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA21: view

Function for IFNA21 Gene

Molecular function for IFNA21 Gene

GENATLAS Biochemistry:
interferon type I,alpha 21,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Phenotypes From GWAS Catalog for IFNA21 Gene

Gene Ontology (GO) - Molecular Function for IFNA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA21: view
genes like me logo Genes that share phenotypes with IFNA21: view

miRNA for IFNA21 Gene

miRTarBase miRNAs that target IFNA21

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFNA21 Gene

Localization for IFNA21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA21 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA21 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA21 Gene

Pathways & Interactions for IFNA21 Gene

genes like me logo Genes that share pathways with IFNA21: view

Gene Ontology (GO) - Biological Process for IFNA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA21: view

No data available for SIGNOR curated interactions for IFNA21 Gene

Drugs & Compounds for IFNA21 Gene

No Compound Related Data Available

Transcripts for IFNA21 Gene

mRNA/cDNA for IFNA21 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNA21 Gene

Interferon, alpha 21:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA21 Gene

No ASD Table

Relevant External Links for IFNA21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNA21 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA21 Gene

This gene is overexpressed in Brain - Cerebellum (x6.0), Brain - Cerebellar Hemisphere (x5.6), and Brain - Frontal Cortex (BA9) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of IFNA21 Gene:


SOURCE GeneReport for Unigene cluster for IFNA21 Gene:


Evidence on tissue expression from TISSUES for IFNA21 Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with IFNA21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA21 Gene

Orthologs for IFNA21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNA21 33 34
  • 100 (n)
(Bos Taurus)
Mammalia -- 34
  • 62 (a)
-- 34
  • 62 (a)
-- 34
  • 62 (a)
-- 34
  • 62 (a)
IFNAG 34 34
  • 62 (a)
  • 62 (a)
-- 34
  • 61 (a)
  • 61 (a)
  • 60 (a)
(Mus musculus)
Mammalia Gm12597 34
  • 61 (a)
Ifna12 34
  • 61 (a)
Ifna5 34
  • 61 (a)
Ifna6 34
  • 61 (a)
Ifna1 34
  • 60 (a)
Ifna13 34
  • 60 (a)
Gm13280 34
  • 59 (a)
Ifna9 34
  • 59 (a)
Ifna14 34
  • 58 (a)
Ifnab 34
  • 58 (a)
Ifna11 34
  • 57 (a)
Ifna2 34
  • 57 (a)
Ifna7 34
  • 57 (a)
Ifna4 34
  • 56 (a)
Species where no ortholog for IFNA21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA21 Gene

Gene Tree for IFNA21 (if available)
Gene Tree for IFNA21 (if available)

Paralogs for IFNA21 Gene

(18) SIMAP similar genes for IFNA21 Gene using alignment to 1 proteins: Pseudogenes for IFNA21 Gene

genes like me logo Genes that share paralogs with IFNA21: view

Variants for IFNA21 Gene

Sequence variations from dbSNP and Humsavar for IFNA21 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000062385 -- 21,165,875(-) C/T 3_prime_UTR_variant
rs1003913995 -- 21,165,553(-) A/G downstream_transcript_variant
rs1008198420 -- 21,165,496(-) G/A/T downstream_transcript_variant
rs1008422992 -- 21,168,389(-) C/G upstream_transcript_variant
rs1010109680 -- 21,166,786(-) CTCTCT/CTCT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNA21 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
nsv613752 CNV loss 21841781
nsv968599 CNV duplication 23825009

Variation tolerance for IFNA21 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA21 Gene

Disorders for IFNA21 Gene

Additional Disease Information for IFNA21

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IFNA21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA21 Gene

Publications for IFNA21 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 44 58
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for IFNA21 Gene

Sources for IFNA21 Gene

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