IFNA21 Gene
protein-coding GIFtS: 52
GCID: GC09M021165
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interferon, alpha 21
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Aliases for IFNA21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Interferon, Alpha 211 2 | | LeIF F2 3 | | IFN-AlphaI1 | | Interferon Alpha-212 | | Interferon Alpha-F2 3 | | LeIF-F1 | | IFN-Alpha-211 | | Leukocyte Interferon Protein2 |
Export aliases for IFNA21 gene to outside databasesPrevious GC identifers: GC09M021493 GC09M021366 GC09M021155 GC09M021128 |
Summaries for IFNA21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for IFNA21: This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokinesproduced in response to viral infection that mediate the immune response and interfere with viral replication. Theencoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus.(provided by RefSeq, Sep 2011) UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase Gene Wiki entry for IFNA21
|
Genomic Views for IFNA21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IFNA21 gene promoter: GR Egr-3 GR-beta POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 Egr-4 RORalpha1 S8 GR-alpha Other transcription factors
Search SABiosciences Chromatin IP Primers for IFNA21
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA21 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22IFNA21 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M021165: view genomic region
(about GC identifiers)
Start:
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21,165,636 bp from pter |
End:
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21,166,659 bp from pter |
Size:
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1,024 bases |
Orientation:
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minus strand |
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Proteins for IFNA21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568 (See
protein sequence)Recommended Name: Interferon alpha-21 precursor Size: 189 amino acids; 21741 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAA36041.1; Type=Erroneous initiation;
Secondary accessions: Q14608 Q5VWD1 Q7M4Q4Explore the universe of human proteins at neXtProt for IFNA21: NX_P01568
IFNA21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002166.2 ENSEMBL proteins: ENSP00000369574 Reactome Protein details: P01568 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005615 | extracellular space |
IEA | -- |
IFNA21 for ontologies About GeneDecksing
IFNA21 Antibody Products: Assay Products for IFNA21: |
Protein
Domains / Families for IFNA21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFNA21 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P01568ProtoNet protein and cluster: P01568 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568Similarity: Belongs to the alpha/beta interferon family |
Function for IFNA21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: IFN21_HUMAN, P01568Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase Genatlas biochemistry entry for IFNA21:interferon type I,alpha 21,leukocyte
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA21 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA21 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNA21 (NM_002175) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA21  |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- | | GO:0005126 | cytokine receptor binding |
IEA | -- |
IFNA21 for ontologies About GeneDecksing
|
Pathways & Interactions for IFNA21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of IFNA signaling | | | 2 | Toll-like receptor signaling pathway | | | 3 | Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway | | | 4 | Cytokine Signaling in Immune system | | | 5 | Immune System | |
Pathway sources See GeneCards unified pathways Show all pathways
2 EMD Millipore Pathways for IFNA21 1 R&D Systems Pathway for IFNA21 4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA21 2 GeneGo (Thomson Reuters) Pathways for IFNA21 1 BioSystems Pathway for IFNA21 
5/11
Reactome Pathways for IFNA21 (see all 11)
5/12
Kegg Pathways (Kegg details for IFNA21) (see all 12):
IFNA21 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA21
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
 4 Interacting proteins for IFNA21 (ENSP000003695744) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
IFNA21 for ontologies About GeneDecksing
|
Drugs & Compounds for IFNA21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for IFNA21 Search CenterWatch for drugs/clinical trials and news about IFNA21 / IFN21 
|
Transcripts for IFNA21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for IFNA21 gene: NM_002175.2 Unigene Cluster for IFNA21: Interferon, alpha 21 Hs.113211 Unigene Representative Sequence: NM_0021751 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000380225(uc003zom.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA21 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA21 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNA21 (NM_002175) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA21  |
Additional cDNA sequence: BC069329.1 BC069372.1 BC069408.1 BC096699.1 BC101638.1 BC101640.1 M12350.1 M28586.1 V00540.1 X00145.1 1 DOTS entry: DT.108640 11 AceView cDNA sequences: BC069408 M28586 BC069372 BC069329 X00145 M12350 V00540 BV199632 NM_002175 BV199628 BV199630 GeneLoc Exon Structure
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Expression for IFNA21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFNA21 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAATATTATG
About this image See IFNA21 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IFNA21
SOURCE GeneReport for Unigene cluster: Hs.113211 SABiosciences Expression via Pathway-Focused PCR Array including IFNA21: | Interferons & Receptors in human mouse rat |
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA21 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFNA21 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA21 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA21 |
Orthologs for IFNA21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFNA21 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for IFNA21 (if available) TreeFam Gene Tree for IFNA21 (if available)  |
Paralogs for IFNA21 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for IFNA21 gene
- IFNA72 IFNA22 IFNE2 IFNA42 IFNA142 IFNK2 IFNA52 IFNA12
- IFNA172 IFNA62 IFNB12 IFNA132 IFNW12 IFNA162 IFNA102 IFNA82
18 SIMAP similar genes for IFNA21 using alignment to 1 protein entry: IFN21_HUMAN:IFNA10 IFNA17 IFNA4 IFNA5 IFNA7 IFN-2 IFNA IFNA14 IFNA16 IFNA1 IFNA13 IFNA6 IFNA8 IFNA2 IFNA2B IFNW1 IFNB1 IFNE
IFNA21 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IFNA21 PGOHUM00000236405
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Genomic Variants for IFNA21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 9 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for IFNA21 (21165636 - 21166659 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for IFNA21: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA21 |
|
Disorders
/ Diseases for IFNA21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFNA21 for disorders About GeneDecksing
OMIM gene information: 147584
OMIM disorders: --
12 diseases for IFNA21: About MalaCardsrubella dengue hemorrhagic fever hemorrhagic fever autoimmune thyroiditis hepatitis c hepatitis b measles hepatitis influenza thyroiditis tuberculosis melanoma 2 diseases from the University of Copenhagen DISEASES database for IFNA21:Hepatitis C Hepatitis B Human Genome Epidemiology (HuGE) Navigator: IFNA21 (5 documents) Export disorders for IFNA21 gene to outside databases
|
Publications for IFNA21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFNA21 gene, integrated from 9 sources (see all 67): (articles sorted by number of sources associating them with IFNA21) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (1998)
- Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (PubMed id 8910771)1, 2 Hussain M.... Liao M.-J. (1996)
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
- Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes. (PubMed id 6548765)1, 2 Gren E....Apsalons U. (1984)
- The structure of eight distinct cloned human leukocyte interferon cDNAs. (PubMed id 6163083)1, 2 Goeddel D.V.... Gray P.W. (1981)
- Inhibitory effects of human immunodeficiency virus gp1 20 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cel ls. (PubMed id 22814248)1 Fang M....Yao H. (2012)
- HIV-1 Gag-virus-like particles inhibit HIV-1 replicati on in dendritic cells and T cells through IFN-a-dependent upregulation of APOBEC 3G and 3F. (PubMed id 22739040)1 Chang M.O....Takaku H. (2012)
- Role of retroviral restriction factors in the interfer on-a-mediated suppression of HIV-1 in vivo. (PubMed id 22315404)1 Pillai S.K....Wong J.K. (2012)
- Structural variants of IFNI+ preferentially promote an tiviral functions. (PubMed id 21757613)1 VA!zquez N....Wahl S.M. (2011)
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External Searches for IFNA21 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IFNA21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFNA21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNA21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for IFNA21 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IFNA21 gene: Search GeneIP for patents involving IFNA21
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for IFNA21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNA21 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA21 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA21 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA21 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA21 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA21 |
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