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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFNA2 Gene

protein-coding GIFtS: 61
GCID: GC09M021374

interferon, alpha 2

Explore 264 diseases affiliated with
IFNA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interferon, Alpha 2¹ ²		Alpha-2a Interferon²
IFN-AlphaA¹		Interferon Alpha 2a²
IFNA¹ ²		Interferon Alpha 2b²
LeIF A² ³		Interferon Alpha A²
IFN-Alpha-2¹		Interferon Alpha-2²
IFNA2B²		Interferon Alpha-A³
INFA2²

External Ids:	HGNC: 5423¹	Entrez Gene: 3440²	Ensembl: ENSG00000188379⁷	OMIM: 147562⁵	UniProtKB: P01563³

Export aliases for IFNA2 gene to outside databases

Previous GC identifers: GC09M021711 GC09M021585

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNA2:

This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced

in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing

the symptoms and duration of the common cold. (provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563

Function: Produced by macrophages, IFN-alpha have antiviral activities

Gene Wiki entry for IFNA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFNA2 gene promoter:
Egr-3 Egr-2 Brachyury LCR-F1 NF-kappaB NF-kappaB1 Egr-4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFNA2 promoter sequence

Search SABiosciences Chromatin IP Primers for IFNA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22

IFNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M021374: view genomic region (about GC identifiers)

Start:	21,384,254 bp from pter	End:	21,385,396 bp from pter
Size:	1,143 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563 (See protein sequence)

Recommended Name: Interferon alpha-2 precursor

Size: 188 amino acids; 21550 Da

Subunit: Interacts with IFNAR2

Subcellular location: Secreted

6/9 PDB 3D structures from and Proteopedia for IFNA2 (see all 9):

1ITF (3D)

1RH2 (3D)

2HIE (3D)

2HYM (3D)

2KZ1 (3D)

2LAG (3D)

Secondary accessions: P01564 Q14606 Q96KI6

Explore the universe of human proteins at neXtProt for IFNA2: NX_P01563

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01563

IFNA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000596.2

ENSEMBL proteins:

ENSP00000369554

Reactome Protein details: P01563
Human Recombinant Protein Products for IFNA2:

	EMD Millipore Purified and/or Recombinant IFNA2 Protein
	R&D Systems Recombinant & Natural Proteins for IFNA2 (IFN-alpha 2, IFN-alpha A, IFN-alpha)
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	Novus Biologicals IFNA2 Proteins Novus Biologicals IFNA2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IFNA2
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

IFNA2 for ontologies About GeneDecksing

IFNA2 Antibody Products:

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	Browse Antibodies at Uscn
	ThermoFisher Antibody for IFNA2

Assay Products for IFNA2:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFNA2 for domains About GeneDecksing

4 InterPro domains/families:

IPR012351 4_helix_cytokine_core

IPR015589 Interferon_alpha

IPR000471 Interferon_alpha/beta/delta

IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P01563

ProtoNet protein and cluster: P01563

1 Blocks protein family: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563

Similarity: Belongs to the alpha/beta interferon family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IFNA2_HUMAN, P01563

Function: Produced by macrophages, IFN-alpha have antiviral activities

Genatlas biochemistry entry for IFNA2:

interferon type I,alpha 2,leukocyte

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005132	interferon-alpha/beta receptor binding	TAS	6158094
GO:0005515	protein binding	IPI	7759950

IFNA2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IFNA2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate IFNA2:
		hsa-miR-203
		SwitchGear 3'UTR luciferase reporter plasmid: IFNA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNA2 OriGene shRNA RFP: IFNA2 OriGene siRNA: IFNA2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against IFNA2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IFNA2
			Sirion Biotech Customized adenovirus for overexpression of IFNA2 Sirion Biotech Customized adenovirus for potent knockdown of IFNA2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA2 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNA2 (NM_000605)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA2

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		Sirion Biotech Customized stable knockdown cell line services for IFNA2 Sirion Biotech Customized inducible knockdown cell line services for IFNA2 Sirion Biotech Customized stable overexpressing cell line services for IFNA2 Sirion Biotech Customized inducible overexpressing cell line services for IFNA2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of IFNA signaling

Regulation of IFNA signaling	1.00	TRAF6 mediated IRF7 activation	0.33
Immune response_IFN alpha/beta signaling pathway	0.71	Cytokine Network	0.28
Immune response IFN alpha/beta signaling pathway	0.71	Regulation of autophagy	0.26
Expression of Interferon-alpha and beta	0.52

Toll-like receptor signaling pathway

	Toll-like receptor signaling pathway	1.00			Toll-Like receptor Signaling Pathways	0.51
	Toll-like receptor signaling pathway	0.97

Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway

Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway

1.00

Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways

0.91

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Immune System

Immune System

1.00

Innate Immune System

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IFNA2

	Immune response IFN alpha/beta signaling pathway
	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

1 R&D Systems Pathway for IFNA2

Toll-Like receptor Signaling Pathways

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA2

	Cytokine Network
	Interferon Pathway
	JAK-STAT Pathway
	all-trans-Retinoic Acid Mediated Apoptosis

2 GeneGo (Thomson Reuters) Pathways for IFNA2

	Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
	Immune response IFN alpha/beta signaling pathway

2 BioSystems Pathways for IFNA2

	Type II interferon signaling (IFNG)
	Toll-like receptor signaling pathway

5/11 Reactome Pathways for IFNA2 (see all 11)

	Hemostasis
	Regulation of IFNA signaling
	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

5/12 Kegg Pathways (Kegg details for IFNA2) (see all 12):

	Cytokine-cytokine receptor interaction
	Regulation of autophagy
	Toll-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	Cytosolic DNA-sensing pathway

IFNA2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IFNA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/22 Interacting proteins for IFNA2 (P01563³ ENSP00000369554⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IFNAR2	P48551³, ENSP00000343957⁴	I2D: score=3 STRING: ENSP00000343957
IFNAR1	P17181³, ENSP00000270139⁴	I2D: score=1 STRING: ENSP00000270139
IFNA14	ENSP00000369571⁴	STRING: ENSP00000369571
IFNA16	ENSP00000369564⁴	STRING: ENSP00000369564
IFNA6	ENSP00000369558⁴	STRING: ENSP00000369558

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006917	induction of apoptosis	TAS	10477584
GO:0006954	inflammatory response	TAS	10477584
GO:0007166	cell surface receptor signaling pathway	TAS	6158094
GO:0007267	cell-cell signaling	TAS	10477584
GO:0007596	blood coagulation	TAS	--

IFNA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IFNA2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNA2
UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563

Pharmaceutical: Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer drug

for its antiproliferative activity

10/137 Novoseek chemical compound relationships for IFNA2 gene (see all 137) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ribavirin	91.7	558	9439491 (9), 10460040 (6), 12702987 (6), 11827565 (5) (see all 99)
intron a	86.1	28	1908702 (2), 1841409 (1), 1553902 (1), 16047150 (1) (see all 27)
pegasys	80	15	12821324 (2), 12627987 (2), 18672534 (1), 15771758 (1) (see all 11)
ifn-alpha	77.3	27	8020725 (2), 2256404 (2), 1810053 (1), 2370758 (1) (see all 25)
dacarbazine	75.7	52	9301463 (2), 10596917 (2), 7520681 (2), 2220660 (2) (see all 36)
5fluorouracil	74.4	288	11710825 (3), 7966664 (3), 1553576 (3), 1553902 (2) (see all 99)
isotretinoin	70.1	78	9476056 (6), 7808023 (2), 9036064 (2), 10834025 (2) (see all 40)
leucovorin	69.9	107	8398300 (3), 1553576 (3), 1557645 (2), 7917927 (2) (see all 65)
alanine	66.1	24	10460040 (1), 10971823 (1), 18020586 (1), 1323873 (1) (see all 23)
pegintron	66	4	12852384 (1), 11190183 (1), 15106411 (1), 15876467 (1)

Search CenterWatch for drugs/clinical trials and news about IFNA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNA2 gene:

NM_000605.3

Unigene Cluster for IFNA2:

Interferon, alpha 2

Hs.211575

Unigene Representative Sequence: NM_000605

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000380206(uc003zpb.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate IFNA2:
		hsa-miR-203
		SwitchGear 3'UTR luciferase reporter plasmid: IFNA2 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNA2 OriGene shRNA RFP: IFNA2 OriGene siRNA: IFNA2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against IFNA2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA2 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IFNA2 (NM_000605)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA2

Additional cDNA sequence:

AY255838.1 BC074936.2 BC074937.2 BC104163.1 BC104164.1 CR541921.1 JN591568.1 JN591569.1

JN591570.1 JN848522.1 M54886.1 V00544.1 V00548.1 V00549.1

1 DOTS entry:

DT.309784

7 AceView cDNA sequences:

BC074936 V00548 BC074937 V00544 M54886 V00549 NM_000605

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCACCTTTG

About this image
See IFNA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA2

SOURCE GeneReport for Unigene cluster: Hs.211575
SABiosciences Expression via Pathway-Focused PCR Arrays including IFNA2 (see all 8):

Antiviral Response in human mouse rat

Interferons & Receptors in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Common Cytokines in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat IFNA2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFNA2 gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	--	33(a)	1 → many	Un(24396419-24396970)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 6)	--	27(a) 25(a) (see all 6)	many ↔ many many ↔ many (see all 6)	2(61647787-61648344) 2(61628582-61629115)
zebrafish (Danio rerio)	Actinopterygii	ifnphi3⁶ ifnphi2⁶	interferon phi 2	27(a) 23(a)	many ↔ many many ↔ many	3(22558521-22560658) 3(22565711-22572180)

ENSEMBL Gene Tree for IFNA2 (if available)
TreeFam Gene Tree for IFNA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IFNA2 gene

IFNA1² IFNA21² IFNA7² IFNA17² IFNE² IFNA4² IFNA6² IFNA14²

IFNB1² IFNW1² IFNA13² IFNA10² IFNA16² IFNA8² IFNA5² IFNK²

18 SIMAP similar genes for IFNA2 using alignment to 2 protein entries: IFNA2_HUMAN (see all proteins):

IFN-2 IFNA2B IFNA IFNA10 IFNA14 IFNA17

IFNA4 IFNA5 IFNA7 IFNA16 IFNA21 IFNA6

IFNA1 IFNA13 IFNA8 IFNW1 IFNE IFNB1

IFNA2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for IFNA2
PGOHUM00000236404

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563

Polymorphism: Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs615077^1,2	C,F	--	21347254(-)	`CTGAAG/CACCTT`	1	--	ds500¹		6		NA WA EA	500
rs625082^1,2	C	--	21347255(-)	`TCTGAG/AGACCT`	1	--	ds500¹		5		NA WA EA	362
rs77482529^1,2	C,F	--	21347624(+)	`TAGGTT/CCACCT`	1	--	ds500¹		1		WA	118
rs180941918^1,2	C	--	21347883(+)	`GGTGCA/GCATGA`	1	--	ut3¹		0	--	--	--	--
rs16938369^1,2	C,F,H	--	21348903(+)	`TATGCA/TCTCTT`	1	--	us2k¹		9		NA NS EA CSA WA	682
rs13297088^1,2	H	--	21348956(+)	`tattgT/Gttcct`	1	--	us2k¹ trp³		4		NS EA	420
rs77567083^1,2		--	21349100(+)	`TATAAA/TGTTAA`	1	--	us2k¹		0	--	--	--	--
rs58487417^1,2	C	--	21349131(+)	`TGATAG/AAACAA`	1	--	us2k¹		1		WA	2
rs12338418^1,2	H	--	21349258(+)	`aataaG/Ttgaaa`	1	--	us2k¹		4		NS EA	414
rs77746835^1,2	C,F	--	21349425(+)	`TCCTAT/CTGTGC`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for IFNA2 (21384254 - 21385396 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFNA2
1 CNV: 8623
Human Gene Mutation Database (HGMD): IFNA2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IFNA2 for disorders           About GeneDecksing

OMIM gene information: 147562    OMIM disorders: --

20/264 diseases for IFNA2 (see all 264):    About MalaCards

common cold blue rubber bleb nevus syndrome vogt-koyanagi-harada disease polyarteritis nodosa

muir-torre syndrome periarteritis nodosa cutaneous polyarteritis nodosa bronchiolitis obliterans organizing pneumonia

necrobiotic xanthogranuloma lymphomatoid granulomatosis tufted angioma subacute sclerosing panencephalitis

disseminated intravascular coagulation kaposiform hemangioendothelioma focal epithelial hyperplasia focal segmental glomerulosclerosis

chronic inflammatory demyelinating polyneuropathy pityriasis rosea recurrent respiratory papillomatosis west nile virus

12 diseases from the University of Copenhagen DISEASES database for IFNA2:

Hepatitis C Hepatitis Hepatitis B Melanoma

Liver cirrhosis Peyronie's disease Renal cell carcinoma Leukopenia

Myeloma Leukemia Thrombocytopenia Carcinoma

10/98 Novoseek disease relationships for IFNA2 gene (see all 98) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis c chronic	92.4	476	9382363 (6), 18020586 (5), 11772139 (4), 9563925 (3) (see all 99)
hepatitis c	83.1	184	7890902 (3), 1323873 (2), 8872767 (2), 11391241 (2) (see all 99)
hepatitis b chronic	79.4	128	7702228 (4), 11517899 (3), 12508364 (3), 15854180 (2) (see all 96)
metastatic renal cell carcinoma	76.5	56	8558634 (2), 10834025 (2), 19920817 (2), 14676797 (2) (see all 47)
hepatitis chronic active	76.2	44	8872767 (2), 7749499 (2), 8790569 (2), 7827383 (2) (see all 38)
stable disease	74.3	3	1795011 (1), 12710586 (1), 2001899 (1)
hepatitis chronic	72.5	29	10989698 (2), 17133585 (1), 18568137 (1), 1289187 (1) (see all 29)
delta hepatitis chronic	69.1	12	8188163 (2), 8586031 (1), 7839006 (1), 9696491 (1) (see all 10)
hepatitis b	68.4	94	7702228 (3), 2031078 (2), 8586031 (2), 8790569 (2) (see all 63)
hepatitis chronic non-a non-b	67.3	10	1362657 (2), 8244259 (2), 1909274 (1), 1953524 (1) (see all 8)

Human Genome Epidemiology (HuGE) Navigator: IFNA2 (10 documents)

Export disorders for IFNA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFNA2 gene, integrated from 9 sources (see all 1753):
(articles sorted by number of sources associating them with IFNA2)

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Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. (PubMed id 8994971)^{1, 2, 9} Radhakrishnan R.... Walter M.R. (1996)
A defective retroviral vector encoding human interferon alpha 2 can transduce human leukemic cell lines. (PubMed id 9694076)^{1, 2} Austruy E.... Chabannon C. (1998)
Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)^{1, 2} Nyman T.A.... Kalkkinen N. (1998)
The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution. (PubMed id 9417943)^{1, 2} Klaus W.... Senn H. (1997)
Interferon-alpha 2 variants in the human genome. (PubMed id 7627809)^{1, 2} Lee N.... Testa D. (1995)
A homology model of human interferon alpha-2. (PubMed id 8234245)^{1, 2} Murgolo N.J.... Trotta P.P. (1993)
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)^{1, 3} Olopade O.I....Diaz M.O. (1992)
Natural human interferon-alpha 2 is O-glycosylated. (PubMed id 2049076)^{1, 2} Adolf G.R.... Cantell K. (1991)
Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli. (PubMed id 3906813)^{1, 2} Oliver G.... Bolivar F. (1985)
Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli. (PubMed id 6310510)^{1, 2} Weber H. and Weissmann C. (1983)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3440	HGNC: 5423	AceView: IFNA2	Ensembl:ENSG00000188379	euGenes: HUgn3440
ECgene: IFNA2	Kegg: 3440	H-InvDB: IFNA2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFNA2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IFNA2 gene
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Patent Information for IFNA2 gene:
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interferon, alpha 2

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Hemangioendothelioma
stable disease
Kaposi Sarcoma
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Serotonin syndrome
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KASABACH-MERRITT SYNDROME
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IFNA2 Gene

interferon, alpha 2

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