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IFNA2 Gene

protein-coding   GIFtS: 64
GCID: GC09M021374

Interferon, Alpha 2

  See IFNA2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Alpha 21 2     IFNA2
Alpha-2a Interferon1 2     IFNA2B2
Interferon Alpha 2b1 2     INFA22
Interferon Alpha A1 2     Interferon Alpha 2a2
LeIF A2 3     Interferon Alpha-22
IFN-alpha-22 3     Interferon Alpha-A3
IFN-alphaA2     

External Ids:    HGNC: 54231   Entrez Gene: 34402   Ensembl: ENSG000001883797   OMIM: 1475625   UniProtKB: P015633   

Export aliases for IFNA2 gene to outside databases

Previous GC identifers: GC09M021711 GC09M021585


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFNA2 Gene:
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine
produced in response to viral infection. Use of the recombinant form of this protein has been shown to be
effective in reducing the symptoms and duration of the common cold. (provided by RefSeq, Jun 2011)

GeneCards Summary for IFNA2 Gene:
IFNA2 (interferon, alpha 2) is a protein-coding gene. Diseases associated with IFNA2 include hemangioendothelioma, and peyronie's disease. GO annotations related to this gene include type I interferon receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563
Function: Produced by macrophages, IFN-alpha have antiviral activities

Gene Wiki entry for IFNA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFNA2 gene promoter:
         Egr-3   Egr-2   Brachyury   LCR-F1   NF-kappaB   NF-kappaB1   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNA2 promoter sequence
   Search Chromatin IP Primers for IFNA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021374:  view genomic region     (about GC identifiers)

Start:
21,384,254 bp from pter      End:
21,385,396 bp from pter
Size:
1,143 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563 (See protein sequence)
Recommended Name: Interferon alpha-2 precursor  
Size: 188 amino acids; 21550 Da
Subunit: Interacts with IFNAR2
Selected PDB 3D structures from and Proteopedia for IFNA2 (see all 9):
1ITF (3D)        1RH2 (3D)        2HIE (3D)        2HYM (3D)        2KZ1 (3D)        2LAG (3D)    
Secondary accessions: P01564 Q14606 Q96KI6

Explore the universe of human proteins at neXtProt for IFNA2: NX_P01563

Explore proteomics data for IFNA2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr129
  • Modification sites at PhosphoSitePlus

  • See IFNA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000596.2  
    ENSEMBL proteins: 
     ENSP00000369554  
    Reactome Protein details: P01563

    IFNA2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IFNA2 Protein
    R&D Systems Recombinant & Natural Proteins for IFNA2 (IFN-alpha 2, IFN-alpha A, IFN-alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IFNA2
    OriGene Protein Over-expression Lysate for IFNA2
    OriGene MassSpec for IFNA2
    OriGene Custom Protein Services for IFNA2
    GenScript Purified and Recombinant Proteins for IFNA2
    Novus Biologicals IFNA2 Proteins
    Novus Biologicals IFNA2 Lysates
    Sino Biological Recombinant Protein for IFNA2
    Sino Biological Cell Lysate for IFNA2
    ProSpec Recombinant Protein for IFNA2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IFNA2 

    IFNA2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IFNA2
    R&D Systems Antibodies for IFNA2 (IFN-alpha)
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    Novus Biologicals IFNA2 Antibodies
    Abcam antibodies for IFNA2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for IFNA2
    LSBio Antibodies in human, mouse, rat for IFNA2

    IFNA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IFNA2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IFNA2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFN: Interferons

    4 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR015589 Interferon_alpha
     IPR000471 Interferon_alpha/beta/delta
     IPR009079 4_helix_cytokine-like_core

    Graphical View of Domain Structure for InterPro Entry P01563

    ProtoNet protein and cluster: P01563

    1 Blocks protein domain: IPB000471 Interferon alpha

    UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563
    Similarity: Belongs to the alpha/beta interferon family


    Find genes that share domains with IFNA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFNA2_HUMAN, P01563
    Function: Produced by macrophages, IFN-alpha have antiviral activities

         Genatlas biochemistry entry for IFNA2:
    interferon type I,alpha 2,leukocyte

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding ----
    GO:0005132type I interferon receptor binding TAS6158094
    GO:0005515protein binding IPI7759950
         
    Find genes that share ontologies with IFNA2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IFNA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IFNA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNA2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IFNA2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IFNA2:
    hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidIFNA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFNA2
    Predesigned siRNA for gene silencing in human, mouse, rat IFNA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFNA2

    Clone
    Products:
         
    OriGene clones in human, mouse for IFNA2 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNA2 (NM_000605)
    Sino Biological Human cDNA Clone for IFNA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IFNA2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA2

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12800) for IFNA2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFNA2_HUMAN, P01563: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IFNA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFNA2 About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    2NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    NOD-like Receptor Signaling Pathways0.58
    3Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    Regulation of IFNA signaling0.69
    4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    5Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34


    Find genes that share SuperPaths with IFNA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IFNA2
        NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IFNA2
        Cytokine Network
    Interferon Pathway
    JAK-STAT Pathway
    all-trans-Retinoic Acid Mediated Apoptosis

    2 GeneGo (Thomson Reuters) Pathways for IFNA2
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response IFN alpha/beta signaling pathway

    3 BioSystems Pathways for IFNA2
        Type II interferon signaling (IFNG)
    Toll-like receptor signaling pathway
    Regulation of toll-like receptor signaling pathway


    4 Reactome Pathways for IFNA2
        Regulation of IFNA signaling
    Interferon alpha/beta signaling
    Factors involved in megakaryocyte development and platelet production
    TRAF6 mediated IRF7 activation


    Selected Kegg Pathways  (Kegg details for IFNA2) (see all 15):
        Cytokine-cytokine receptor interaction
    Regulation of autophagy
    PI3K-Akt signaling pathway
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNA2 (see all 8): 
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IFNA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for IFNA2 (P015633 ENSP000003695544) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFNAR2P485513, ENSP000003439574I2D: score=3 STRING: ENSP00000343957
    IFNAR1P171813, ENSP000002701394I2D: score=1 STRING: ENSP00000270139
    IFNA14ENSP000003695714STRING: ENSP00000369571
    IFNA16ENSP000003695644STRING: ENSP00000369564
    IFNA6ENSP000003695584STRING: ENSP00000369558
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS10477584
    GO:0006952defense response ----
    GO:0006954inflammatory response TAS10477584
    GO:0007166cell surface receptor signaling pathway TAS6158094
    GO:0007267cell-cell signaling TAS10477584

    Find genes that share ontologies with IFNA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFNA2

    UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563
    Pharmaceutical: Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer
    drug for its antiproliferative activity

    Selected Novoseek inferred chemical compound relationships for IFNA2 gene (see all 137)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribavirin 91.7 558 9439491 (9), 10460040 (6), 12702987 (6), 11827565 (5) (see all 99)
    intron a 86.1 28 1908702 (2), 1841409 (1), 1553902 (1), 16047150 (1) (see all 27)
    pegasys 80 15 12821324 (2), 12627987 (2), 18672534 (1), 15771758 (1) (see all 11)
    ifn-alpha 77.3 27 8020725 (2), 2256404 (2), 1810053 (1), 2370758 (1) (see all 25)
    dacarbazine 75.7 52 9301463 (2), 10596917 (2), 7520681 (2), 2220660 (2) (see all 36)
    5fluorouracil 74.4 288 11710825 (3), 7966664 (3), 1553576 (3), 1553902 (2) (see all 99)
    isotretinoin 70.1 78 9476056 (6), 7808023 (2), 9036064 (2), 10834025 (2) (see all 40)
    leucovorin 69.9 107 8398300 (3), 1553576 (3), 1557645 (2), 7917927 (2) (see all 65)
    alanine 66.1 24 10460040 (1), 10971823 (1), 18020586 (1), 1323873 (1) (see all 23)
    pegintron 66 4 12852384 (1), 11190183 (1), 15106411 (1), 15876467 (1)



    Find genes that share compounds with IFNA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFNA2 gene: 
    NM_000605.3  

    Unigene Cluster for IFNA2:

    Interferon, alpha 2
    Hs.211575
    Unigene Representative Sequence: NM_000605
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380206(uc003zpb.3)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate IFNA2:
    hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidIFNA2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat IFNA2
    Clone
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    GenScript: all cDNA clones in your preferred vector: IFNA2 (NM_000605)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IFNA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFNA2
      QuantiTect SYBR Green Assays in human, mouse, rat IFNA2
      QuantiFast Probe-based Assays in human, mouse, rat IFNA2
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12800) for IFNA2 

    Additional mRNA sequence: 

    AY255838.1 BC074936.2 BC074937.2 BC104163.1 BC104164.1 CR541921.1 JN591568.1 JN591569.1 
    JN591570.1 JN848522.1 M54886.1 V00544.1 V00548.1 V00549.1 

    1 DOTS entry:

    DT.309784 

    7 AceView cDNA sequences:

    BC074936 BC074937 V00548 V00549 V00544 M54886 NM_000605 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFNA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACCTTTG
    IFNA2 Expression
    About this image


    IFNA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Epidermis (Integumentary System)
             MSC-containing human skin substitute (Grafix)
    IFNA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFNA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211575
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNA2 (see all 8): 
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFNA2
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IFNA2
    QuantiTect SYBR Green Assays in human, mouse, rat IFNA2
    QuantiFast Probe-based Assays in human, mouse, rat IFNA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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      --

    ENSEMBL Gene Tree for IFNA2 (if available)
    TreeFam Gene Tree for IFNA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFNA2 gene
    IFNA72  IFNA42  IFNE2  IFNA142  IFNA52  IFNK2  IFNA12  IFNA212  
    IFNA172  IFNA62  IFNB12  IFNA132  IFNW12  IFNA162  IFNA102  IFNA82  
    18 SIMAP similar genes for IFNA2 using alignment to 2 protein entries:     IFNA2_HUMAN (see all proteins):
    IFN-2    IFNA2B    IFNA    IFNA10    IFNA14    IFNA17
    IFNA4    IFNA5    IFNA7    IFNA16    IFNA21    IFNA6
    IFNA1    IFNA13    IFNA8    IFNW1    IFNE    IFNB1

    Find genes that share paralogs with IFNA2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IFNA2
    PGOHUM00000236404


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    IFNA2_HUMAN, P01563: Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c


    Selected SNPs for IFNA2 (see all 108)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363294
    A breast cancer sample4--see VAR_0363292 S L mis40--------
    rs6150771,2
    C,F--21378569(-) CTGAAG/CACCTT 1 -- ds50016Minor allele frequency- C:0.08NA WA EA 500
    rs6250821,2
    C--21378570(-) TCTGAG/ACACCT 1 -- ds50015Minor allele frequency- A:0.10NA WA EA 362
    rs6247041,2
    C,F,A,H--21378615(-) GGTGTC/TGGGAG 1 -- ds500131Minor allele frequency- T:0.45NS EA NA WA CSA 2856
    rs1841265671,2
    --21378672(+) CAATCG/TCATTC 1 -- ds50010--------
    rs768915321,2
    C--21378932(+) TATTTG/TTTAGG 1 -- ds50010--------
    rs774825291,2
    C,F--21378939(+) TAGGTT/CCACCT 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1381042331,2
    C--21378995(+) TTTTAC/TTTATA 1 -- ut310--------
    rs1495601221,2
    --21379055(+) ATCAGG/TTTGCA 1 -- ut310--------
    rs101209771,2
    C,F,A,H--21379080(+) ATTTCA/GTTTTA 1 -- ut3118Minor allele frequency- G:0.12NA NS EA WA 2026

    HapMap Linkage Disequilibrium report for IFNA2 (21384254 - 21385396 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for IFNA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv892737CNV Loss21882294
    nsv892724CNV Gain21882294
    nsv892736CNV Gain21882294
    nsv892738CNV Gain21882294
    esv2752289CNV Gain17911159

    Human Gene Mutation Database (HGMD): IFNA2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IFNA2
    DNA2.0 Custom Variant and Variant Library Synthesis for IFNA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147562    OMIM disorders: --

    Selected diseases for IFNA2 (see all 64):    
    About MalaCards
    hemangioendothelioma    peyronie's disease    periarteritis nodosa    epithelioid hemangioendothelioma
    common cold    cutaneous t cell lymphoma    peyronies disease    bronchiolitis obliterans organizing pneumonia
    cutaneous polyarteritis nodosa    panuveitis    focal epithelial hyperplasia    orchitis
    propriospinal myoclonus    granulomatous hepatitis    cryoglobulinemic vasculitis    blue rubber bleb nevus syndrome
    laryngeal papillomatosis    giant hemangioma    lymphomatoid granulomatosis    discoid lupus erythematosus

    12 diseases from the University of Copenhagen DISEASES database for IFNA2:
    Hepatitis C     Hepatitis     Hepatitis B     Melanoma
    Peyronie's disease     Renal cell carcinoma     Leukopenia     Liver cirrhosis
    Myeloma     Leukemia     Thrombocytopenia     Carcinoma

    Find genes that share disorders with IFNA2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IFNA2 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c chronic 92.4 476 9382363 (6), 18020586 (5), 11772139 (4), 9563925 (3) (see all 99)
    hepatitis c 83.1 184 7890902 (3), 1323873 (2), 8872767 (2), 11391241 (2) (see all 99)
    hepatitis b chronic 79.4 128 7702228 (4), 11517899 (3), 12508364 (3), 15854180 (2) (see all 96)
    metastatic renal cell carcinoma 76.5 56 8558634 (2), 10834025 (2), 19920817 (2), 14676797 (2) (see all 47)
    hepatitis chronic active 76.2 44 8872767 (2), 7749499 (2), 8790569 (2), 7827383 (2) (see all 38)
    stable disease 74.3 3 1795011 (1), 12710586 (1), 2001899 (1)
    hepatitis chronic 72.5 29 10989698 (2), 17133585 (1), 18568137 (1), 1289187 (1) (see all 29)
    delta hepatitis chronic 69.1 12 8188163 (2), 8586031 (1), 7839006 (1), 9696491 (1) (see all 10)
    hepatitis b 68.4 94 7702228 (3), 2031078 (2), 8586031 (2), 8790569 (2) (see all 63)
    hepatitis chronic non-a non-b 67.3 10 1362657 (2), 8244259 (2), 1909274 (1), 1953524 (1) (see all 8)

    Genetic Association Database (GAD): IFNA2
    Human Genome Epidemiology (HuGE) Navigator: IFNA2 (10 documents)

    Export disorders for IFNA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFNA2 gene, integrated from 10 sources (see all 1763):
    (articles sorted by number of sources associating them with IFNA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic association of interferon-alpha subtypes 1, 2 and 5 in systemic lupus erythematosus. (PubMed id 19000144)1, 4, 9 Hirankarn N....Avihingsanon Y. (Tissue Antigens 2008)
    2. Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. (PubMed id 8994971)1, 2, 9 Radhakrishnan R.... Walter M.R. (Structure 1996)
    3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    4. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (Fam. Cancer 2010)
    5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    8. A globally occurring indel polymorphism in the promoter of the IFNA2 gene is not associated with severity of malaria but with the positivity rate of HCV. (PubMed id 19055755)1, 4 Tena-TomA!s C....Kun J.F. (BMC Genet. 2008)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    10. A promoter polymorphism in the interferon alpha-2 gene is associated with the clinical presentation of hepatitis B. (PubMed id 16920161)1, 4 Song l.e. .H....Kun J.F. (Mutat. Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3440 HGNC: 5423 AceView: IFNA2 Ensembl:ENSG00000188379 euGenes: HUgn3440
    ECgene: IFNA2 Kegg: 3440 H-InvDB: IFNA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IFNA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IFNA2 gene:
    Search GeneIP for patents involving IFNA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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