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Aliases & Descriptions for IFNA2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| IFNA 1, 2 | | INFA2 2 | | MGC125764 2 | | MGC125765 2 | | OTTHUMP00000021143 2 |
| | | Descriptions |
|---|
| Interferon alpha-A 3 | | LeIF A 3 | | alpha-2a interferon 2 | | interferon alpha 2b 2 | | interferon alpha A 2 | | interferon, alpha 2 2 |
|
| | Search outside databases for aliases for IFNA2 genePrevious GC identifers: GC09M021711 GC09M021585 |
Summaries for IFNA2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetaseGene Wiki entry for IFNA2 |
Genomic Location for IFNA2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the IFNA2 gene 
Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22IFNA2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M021374:
(about GC identifiers)
Start:
|
21,374,253 bp from pter |
End:
|
21,375,396 bp from pter |
Size:
|
1,144 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008413.17
| Proteins for IFNA2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563 (See
protein sequence)Recommended Name: Interferon alpha-2 precursor Size: 188 amino acids; 21550 Da
Subcellular location: Secreted
PDB structures from and Proteopedia :1ITF (3D)
 1RH2 (3D)
 2HIE (3D)
 2HYM (3D)
 
Secondary accessions: P01564 Q14606 Q96KI6REFSEQ proteins: NP_000596.2
ENSEMBL proteins: ENSP00000369554
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005615 | extracellular space |
IEA | -- | About this table
Antibodies for IFNA2: Assays for IFNA2: | Protein
Domains/ Families for IFNA2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P01563
ProtoNet protein and cluster: P01563 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563Similarity: Belongs to the alpha/beta interferon family | Gene Function for IFNA2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000605
Applied Biosystems Silencer® siRNAs for IFNA2
Sigma-Aldrich siRNA for IFNA2  Sigma-Aldrich shRNA Panels and shRNA for IFNA2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000605                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000605                                  untagged cDNA clone in CMV expression vector: NM_000605 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000605
UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetaseGenatlas biochemistry entry for IFNA2:interferon type I,alpha 2,leukocyte2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for IFNA2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Sigma-Aldrich "Your Favorite Gene" Pathways for IFNA2 (Your Favorite Gene powered by Ingenuity) 
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for IFNA2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for IFNA2 UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563Pharmaceutical: Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer drug for its antiproliferative activity 10/37 Novoseek chemical compound relationships for IFNA2 gene (see all 37
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ifn-alpha |
77.56 |
27 |
8020725 (2), 2256404 (2), 1810053 (1), 2370758 (1) (see all 25) |
| neopterin |
35.21 |
1 |
1341444 (1) |
| nucleoside |
31.31 |
2 |
18221608 (1) |
| ukrain |
21.31 |
1 |
11345036 (1) |
| ribonucleic acid |
19.47 |
3 |
9212590 (1), 15108250 (1) |
| colchicine |
13.26 |
3 |
7973911 (1), 17883285 (1), 8360992 (1) |
| cellulose |
5.57 |
1 |
17391680 (1) |
| methionine |
4.07 |
1 |
8860434 (1) |
| zinc |
1.54 |
4 |
18449861 (1), 12666823 (1), 17874825 (1), 8994971 (1) |
| iron |
1.45 |
2 |
9845473 (1), 18613407 (1) |
About this table
|
Transcripts for IFNA2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000605
Sigma-Aldrich siRNA for IFNA2  Sigma-Aldrich shRNA Panels and shRNA for IFNA2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000605 REFSEQ mRNAs for IFNA2 gene: NM_000605.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000605               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000605                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000605                                  untagged cDNA clone in CMV expression vector: NM_000605  Additional cDNA sequence: AY255838.1 BC074936.2 BC074937.2 BC104163.1 BC104164.1 CR541921.1 M54886.1 V00544.1 V00548.1 V00549.1 1 DOTS entry: DT.309784 7 AceView cDNA sequences:BC074936 BC074937 V00548 NM_000605 M54886 V00544 V00549
highest scoring ESTs for IFNA2:M54886 V00544 V00548 V00549 AY255838 BC074936 BC074937 NM_000605 BC104163 BC104164 Unigene Cluster for IFNA2: Interferon, alpha 2 Hs.211575 Unigene Representative Sequence: NM_000605
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000380206
|
Expression for IFNA2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| IFNA2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for IFNA2
1 / 2 / 3 4 probe-sets matching IFNA2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGCACCTTTG
SOURCE GeneReport for Unigene cluster: Hs.211575
Expression variation in blood from EXPOLDB for IFNA2 |
Orthologs for IFNA2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IFNA2 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
chimpanzee (Pan troglodytes) |
LOC4731981 |
-- |
similar to interferon alpha 2b |
99.65(n) 98.94(a) |
473198 XM_528568.2 XP_528568.1 |
About this table Species with no ortholog for IFNA2
ENSEMBL Gene Tree for IFNA2 | Paralogs for IFNA2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for IFNA2 gene
- IFNA12 IFNA212 IFNA72 IFNA172 IFNA42 IFNA62 IFNA142 IFNA132
- IFNA162 IFNA102 IFNA82 IFNA52
|
SNPs/Variants for IFNA2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563Polymorphism: Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c
HapMap Linkage Disequilibrium images for IFNA2 (up to first 250kb)
|
Disorders & Mutations for IFNA2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 147562
10/97 Novoseek disease relationships for IFNA2 gene (see all 97
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hepatitis c chronic |
92.16 |
454 |
9382363 (6), 18020586 (5), 11772139 (4), 9563925 (3) (see all 99) |
| hepatitis c |
82.42 |
173 |
7890902 (3), 1323873 (2), 8872767 (2), 11391241 (2) (see all 99) |
| hepatitis b chronic |
79.24 |
122 |
7702228 (4), 11517899 (3), 12508364 (3), 15854180 (2) (see all 92) |
| metastatic renal cell carcinoma |
76.33 |
51 |
8558634 (2), 10834025 (2), 2321276 (2), 7754540 (2) (see all 43) |
| hepatitis chronic active |
76.13 |
43 |
8872767 (2), 7749499 (2), 8790569 (2), 7827383 (2) (see all 37) |
| stable disease |
74.43 |
3 |
1795011 (1), 12710586 (1), 2001899 (1) |
| hepatitis chronic |
72.22 |
30 |
10989698 (2), 1289187 (1), 17133585 (1), 18568137 (1) (see all 29) |
| delta hepatitis chronic |
69.61 |
12 |
8188163 (2), 8586031 (1), 7839006 (1), 9696491 (1) (see all 10) |
| hepatitis b |
68.04 |
78 |
7702228 (3), 2031078 (2), 2186494 (2), 8790569 (2) (see all 59) |
| hepatitis chronic non-a non-b |
67.74 |
10 |
1362657 (2), 8244259 (2), 1909274 (1), 1953524 (1) (see all 8) |
About this table
Human Gene Mutation Database: IFNA2 Human Genome Epidemiology Navigator: IFNA2 (5 documents)
|
Medical News for IFNA2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for IFNA2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/1343 PubMed articles for IFNA2 gene (see all 1343
):- Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. (PubMed id 8994971)1, 3, 4 Radhakrishnan R.... Walter M.R. (1996)
- A defective retroviral vector encoding human interferon alpha 2 can transduce human leukemic cell lines. (PubMed id 9694076)3, 4 Austruy E.... Chabannon C. (1998)
- Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)3, 4 Nyman T.A.... Kalkkinen N. (1998)
- The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution. (PubMed id 9417943)3, 4 Klaus W.... Senn H. (1997)
- Interferon-alpha 2 variants in the human genome. (PubMed id 7627809)3, 4 Lee N.... Testa D. (1995)
- A homology model of human interferon alpha-2. (PubMed id 8234245)3, 4 Murgolo N.J.... Trotta P.P. (1993)
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)2, 3 Olopade O.I....Diaz M.O. (1992)
- Natural human interferon-alpha 2 is O-glycosylated. (PubMed id 2049076)3, 4 Adolf G.R.... Cantell K. (1991)
- Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli. (PubMed id 3906813)3, 4 Oliver G.... Bolivar F. (1985)
- Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli. (PubMed id 6310510)3, 4 Weber H. and Weissmann C. (1983)
|
Search for IFNA2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IFNA2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing IFNA2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNA2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for IFNA2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for IFNA2:

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Incremental update: 13 Oct 2009
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