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Aliases for IFNA2 Gene

Aliases for IFNA2 Gene

  • Interferon Alpha 2 2 3 5
  • Alpha-2a Interferon 2 3
  • Interferon Alpha 2b 2 3
  • Interferon Alpha A 2 3
  • IFN-Alpha-2 3 4
  • LeIF A 3 4
  • IFNA2B 3 4
  • Interferon Alpha 2a 3
  • Interferon Alpha-2 3
  • Interferon Alpha-A 4
  • IFN-AlphaA 3
  • IFNA2A 4
  • IFNA2C 4
  • INFA2 3
  • IFNA 3

External Ids for IFNA2 Gene

Previous GeneCards Identifiers for IFNA2 Gene

  • GC09M021711
  • GC09M021585

Summaries for IFNA2 Gene

Entrez Gene Summary for IFNA2 Gene

  • This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]

GeneCards Summary for IFNA2 Gene

IFNA2 (Interferon Alpha 2) is a Protein Coding gene. Diseases associated with IFNA2 include Peyronie's Disease and Hepatitis C. Among its related pathways are Type I Interferon Signaling Pathways and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA6.

UniProtKB/Swiss-Prot for IFNA2 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities.

Gene Wiki entry for IFNA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA2 Gene

Genomics for IFNA2 Gene

Regulatory Elements for IFNA2 Gene

Enhancers for IFNA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G021381 1.2 Ensembl ENCODE 0.7 +3.4 3431 1.1 TBP PKNOX1 FOXA2 TBL1XR1 WRNIP1 SIN3A BMI1 YBX1 RFX5 CBX5 IFNA2 IFNA13
GH09G021397 0.8 ENCODE 0.4 -10.9 -10930 0.2 SIN3A ZNF2 ZNF48 RAD21 ZNF335 ZNF121 GLIS2 ZNF143 ZNF207 ZNF654 ENSG00000261696 IFNA2
GH09G021398 0.8 ENCODE 0.4 -10.7 -10710 0.2 SIN3A BMI1 ZNF2 ZNF48 RAD21 ZNF335 ZNF121 GLIS2 ZNF143 ZNF207 ENSG00000261696 IFNA2
GH09G021388 0.3 FANTOM5 0.7 -3.0 -2952 0.0 IFNA2 ENSG00000261696
GH09G021372 0.3 FANTOM5 0.4 +12.6 12589 0.0 IFNA13 IFNA2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFNA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNA2 Gene

Chromosome:
9
Start:
21,384,254 bp from pter
End:
21,385,397 bp from pter
Size:
1,144 bases
Orientation:
Minus strand

Genomic View for IFNA2 Gene

Genes around IFNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA2 Gene

Proteins for IFNA2 Gene

  • Protein details for IFNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01563-IFNA2_HUMAN
    Recommended name:
    Interferon alpha-2
    Protein Accession:
    P01563
    Secondary Accessions:
    • H2DF54
    • H2DF55
    • P01564
    • Q14606
    • Q6DJX8
    • Q96KI6

    Protein attributes for IFNA2 Gene

    Size:
    188 amino acids
    Molecular mass:
    21550 Da
    Quaternary structure:
    • Interacts with IFNAR2.

    Three dimensional structures from OCA and Proteopedia for IFNA2 Gene

neXtProt entry for IFNA2 Gene

Post-translational modifications for IFNA2 Gene

  • Glycosylation at posLast=129129
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Assay Products

No data available for DME Specific Peptides for IFNA2 Gene

Domains & Families for IFNA2 Gene

Gene Families for IFNA2 Gene

Suggested Antigen Peptide Sequences for IFNA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01563

UniProtKB/Swiss-Prot:

IFNA2_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA2: view

Function for IFNA2 Gene

Molecular function for IFNA2 Gene

GENATLAS Biochemistry:
interferon type I,alpha 2,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities.

Gene Ontology (GO) - Molecular Function for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS 6158094
GO:0005515 protein binding IPI 7759950
genes like me logo Genes that share ontologies with IFNA2: view
genes like me logo Genes that share phenotypes with IFNA2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA2 Gene

Localization for IFNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA2 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with IFNA2: view

Pathways & Interactions for IFNA2 Gene

SuperPathways for IFNA2 Gene

SuperPathway Contained pathways
1 Toll-Like receptor Signaling Pathways
2 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
3 Toll-like Receptor Signaling Pathway
4 Type I Interferon Signaling Pathways
5 Immune response IFN alpha/beta signaling pathway
genes like me logo Genes that share pathways with IFNA2: view

Gene Ontology (GO) - Biological Process for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006915 apoptotic process TAS 10477584
GO:0006952 defense response IEA --
GO:0006954 inflammatory response TAS 10477584
genes like me logo Genes that share ontologies with IFNA2: view

No data available for SIGNOR curated interactions for IFNA2 Gene

Drugs & Compounds for IFNA2 Gene

(90) Drugs for IFNA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(47) Additional Compounds for IFNA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNA2: view

Transcripts for IFNA2 Gene

mRNA/cDNA for IFNA2 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA2 Gene

No ASD Table

Relevant External Links for IFNA2 Gene

GeneLoc Exon Structure for
IFNA2
ECgene alternative splicing isoforms for
IFNA2

Expression for IFNA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFNA2 Gene

This gene is overexpressed in Cardia (47.6), Heart (14.3), and Fetal heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFNA2 Gene



Protein tissue co-expression partners for IFNA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNA2 Gene:

IFNA2

SOURCE GeneReport for Unigene cluster for IFNA2 Gene:

Hs.211575

Evidence on tissue expression from TISSUES for IFNA2 Gene

  • Blood(2.6)
  • Liver(2.4)
  • Kidney(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with IFNA2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA2 Gene

Orthologs for IFNA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA2 34 35
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 62 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
IFNAG 35 35
  • 62 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
IFNAA 35
  • 61 (a)
ManyToMany
IFNAH 35
  • 61 (a)
ManyToMany
INFAF 35
  • 61 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ifna12 35
  • 62 (a)
ManyToMany
Ifna5 35
  • 62 (a)
ManyToMany
Gm13280 35
  • 61 (a)
ManyToMany
Ifna1 35
  • 61 (a)
ManyToMany
Ifna13 35
  • 61 (a)
ManyToMany
Ifna6 35
  • 61 (a)
ManyToMany
Gm12597 35
  • 60 (a)
ManyToMany
Ifna14 35
  • 60 (a)
ManyToMany
Ifna9 35
  • 60 (a)
ManyToMany
Ifna11 35
  • 58 (a)
ManyToMany
Ifna2 35
  • 58 (a)
ManyToMany
Ifnab 35
  • 58 (a)
ManyToMany
Ifna7 35
  • 57 (a)
ManyToMany
Ifna4 35
  • 56 (a)
ManyToMany
Species where no ortholog for IFNA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA2 Gene

ENSEMBL:
Gene Tree for IFNA2 (if available)
TreeFam:
Gene Tree for IFNA2 (if available)

Paralogs for IFNA2 Gene

(18) SIMAP similar genes for IFNA2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for IFNA2 Gene

genes like me logo Genes that share paralogs with IFNA2: view

Variants for IFNA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA2 Gene

IFNA2_HUMAN-P01563
Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c (PubMed:7627809).

Sequence variations from dbSNP and Humsavar for IFNA2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_036329 A breast cancer sample
rs1000122363 -- 21,386,078(+) GTGCC(C/T)GTTAG upstream-variant-2KB
rs1001075147 -- 21,384,604(+) CCTTA(A/T)GAGCT utr-variant-3-prime
rs1002164350 -- 21,384,013(+) TAATA(C/G)ATGTA downstream-variant-500B
rs1002427114 -- 21,385,584(+) CCTTT(A/T)TAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNA2 Gene

Variant ID Type Subtype PubMed ID
esv2752289 CNV gain 17911159
esv2764150 CNV gain+loss 21179565
nsv982201 CNV duplication 23825009

Variation tolerance for IFNA2 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA2 Gene

Human Gene Mutation Database (HGMD)
IFNA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA2

Disorders for IFNA2 Gene

MalaCards: The human disease database

(86) MalaCards diseases for IFNA2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
peyronie's disease
  • peyronies disease
hepatitis c
  • chronic hepatitis c
hepatitis d
  • delta hepatitis
hepatitis b
  • chronic hepatitis b
lymphomatoid granulomatosis
  • lyg
- elite association - COSMIC cancer census association via MalaCards
Search IFNA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFNA2

Genetic Association Database (GAD)
IFNA2
Human Genome Epidemiology (HuGE) Navigator
IFNA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA2
genes like me logo Genes that share disorders with IFNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA2 Gene

Publications for IFNA2 Gene

  1. Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. (PMID: 8994971) Radhakrishnan R. … Walter M.R. (Structure 1996) 3 4 22 64
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64
  4. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 46 64
  5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 64

Products for IFNA2 Gene

Sources for IFNA2 Gene

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