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IFNA2 Gene

protein-coding   GIFtS: 59

GC09M021374
interferon, alpha 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
IFNA 1, 2
INFA2 2
MGC125764 2
MGC125765 2
OTTHUMP00000021143 2
Descriptions
Interferon alpha-A 3
LeIF A 3
alpha-2a interferon 2
interferon alpha 2b 2
interferon alpha A 2
interferon, alpha 2 2
External Ids
HGNC: 54231
Entrez Gene: 34402
UniProtKB: P015633
Ensembl: ENSG000001883797
Search outside databases for aliases for IFNA2 gene

Previous GC identifers: GC09M021711 GC09M021585

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the
production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFNA2 gene  

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021374:     (about GC identifiers)

Start:
21,374,253 bp from pter
End:
21,375,396 bp from pter
Size:
1,144 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000009.10  NT_008413.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563 (See protein sequence)
Recommended Name: Interferon alpha-2 precursor  
Size: 188 amino acids; 21550 Da
Subcellular location: Secreted
PDB structures from and Proteopedia :
1ITF (3D)    1RH2 (3D)    2HIE (3D)    2HYM (3D)    
Secondary accessions: P01564 Q14606 Q96KI6

REFSEQ proteins: NP_000596.2  

ENSEMBL proteins: 
ENSP00000369554 


Human Recombinant Proteins 
Invitrogen human recombinant proteins for IFNA2
Millipore Purified and/or Recombinant IFNA2 Protein
Sigma-Aldrich Proteins for IFNA2  
R&D Systems Recombinant & Natural Proteins for IFNA2 (IFN-alpha 2, IFN-alpha A, IFN-alpha)
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Interferon alpha 2, Interferon alpha 2b, Interferon Alpha A+D)
Human Recombinant Proteins from Abnova (IFNA2)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005615 extracellular space IEA--
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Antibodies for IFNA2: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of IFNA2
Sigma-Aldrich Antibodies for IFNA2
R&D Systems Antibodies for IFNA2 (IFN-alpha)
Antibodies from Abcam (Interferon alpha 2, Interferon alpha 2b, Interferon Alpha A+D), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (IFNA2)
Novus Biologicals Antibodies for IFNA2

Assays for IFNA2: 
Browse Invitrogen for biochemical assays
Millipore Kits and Assays for the Analysis of IFNA2
R&D Systems ELISAs for IFNA2 (IFN-alpha)         (see all)
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro domains/families:
 IPR012351 4_helix_cytokine_core
 IPR015589 Interferon_alpha
 IPR000471 IInterferon_alpha/beta/delta


   GeneDecks  IFNA2 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P01563

ProtoNet protein and cluster: P01563

1 Blocks protein family: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563
Similarity: Belongs to the alpha/beta interferon family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFNA2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (IFNA2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000605

              Applied Biosystems Silencer® siRNAs for IFNA2

              Sigma-Aldrich siRNA for IFNA2  
                     Sigma-Aldrich shRNA Panels and shRNA for IFNA2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for IFNA2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000605
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000605
                                 untagged cDNA clone in CMV expression vector: NM_000605 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000605

UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the
production of two enzymes: a protein kinase and an oligoadenylate synthetase

Genatlas biochemistry entry for IFNA2:
interferon type I,alpha 2,leukocyte

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005125 cytokine activity IEA--
GO:0005132 interferon-alpha/beta receptor binding TAS6158094
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Invitrogen iPath™ Online BioAtlas - Pathway for IFNA2 (Maps provided by GeneGo):
 IFN alpha/beta signaling pathway

   GeneDecks  IFNA2 for the pathways selected above  
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2 Millipore Pathways for IFNA2
 Immune response IFN alpha/beta signaling pathway
  TICAM1-specific signaling pathways

   GeneDecks  IFNA2 for the pathways selected above  
About GeneDecksing

4 Sigma-Aldrich "Your Favorite Gene" Pathways for  IFNA2  (Your Favorite Gene powered by Ingenuity) 
 Activation of IRF by Cytosolic Pattern Recognition Receptors
 IL-12 Signaling and Production in Macrophages
 Role of Cytokines in Mediating Communication between Immune Cells
 Role of RIG1-like Receptors in Antiviral Innate Immunity

   GeneDecks  IFNA2 for the pathways selected above  
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5/7 Kegg Pathways  (Kegg details for IFNA2) (see all 7 ):
 hsa04060 Cytokine-cytokine receptor interaction
 hsa04140 Regulation of autophagy
 hsa04612 Antigen processing and presentation
 hsa04620 Toll-like receptor signaling pathway
 hsa04630 Jak-STAT signaling pathway

   GeneDecks  IFNA2 for the pathways selected above  
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5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006917 induction of apoptosis TAS10477584
GO:0006954 inflammatory response TAS10477584
GO:0007166 cell surface receptor linked signal transduction TAS6158094
GO:0007267 cell-cell signaling TAS10477584
GO:0009615 response to virus IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFNA2
UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563
Pharmaceutical: Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as
an anticancer drug for its antiproliferative activity

10/37 Novoseek chemical compound relationships for IFNA2 gene (see all 37 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
ifn-alpha 77.56 27 8020725 (2), 2256404 (2), 1810053 (1), 2370758 (1) (see all 25)
neopterin 35.21 1 1341444 (1)
nucleoside 31.31 2 18221608 (1)
ukrain 21.31 1 11345036 (1)
ribonucleic acid 19.47 3 9212590 (1), 15108250 (1)
colchicine 13.26 3 7973911 (1), 17883285 (1), 8360992 (1)
cellulose 5.57 1 17391680 (1)
methionine 4.07 1 8860434 (1)
zinc 1.54 4 18449861 (1), 12666823 (1), 17874825 (1), 8994971 (1)
iron 1.45 2 9845473 (1), 18613407 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (IFNA2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (IFNA2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000605

              Sigma-Aldrich siRNA for IFNA2  
                     Sigma-Aldrich shRNA Panels and shRNA for IFNA2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000605  

REFSEQ mRNAs for IFNA2 gene: 

NM_000605.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000605  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000605
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000605
                                 untagged cDNA clone in CMV expression vector: NM_000605 

Additional cDNA sequence: 

AY255838.1 BC074936.2 BC074937.2 BC104163.1 BC104164.1 CR541921.1 M54886.1 V00544.1 
V00548.1 V00549.1 

1 DOTS entry:

DT.309784 

7 AceView cDNA sequences:

BC074936 BC074937 V00548 NM_000605 M54886 V00544 V00549 

highest scoring ESTs for IFNA2:

M54886 V00544 V00548 V00549 AY255838 BC074936 BC074937 NM_000605 BC104163 BC104164 

Unigene Cluster for IFNA2:

Interferon, alpha 2
Hs.211575
Unigene Representative Sequence: NM_000605


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000380206  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFNA2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IFNA2

1 / 2 / 3

4 probe-sets matching IFNA2 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1791_s_at2, 3 U95-A 2 1.00 0.97 0.57 1.12 J00207 0.20 1.00 0.72 1

1770_at2, 3 U95-A 1 0.81 1.00 0.92 1.08 J00207 0.20 1.00 0.72 1

211338_at2, 3 U133-A 1 1.00 1.00 -- -- M54886 0.80 1.00 0.91 1

211338_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TGCACCTTTG

SOURCE GeneReport for Unigene cluster: Hs.211575

Expression variation in blood from EXPOLDB for IFNA2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for IFNA2 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
LOC4731981   -- similar to interferon alpha 2b 99.65(n)
98.94(a)
473198  XM_528568.2  XP_528568.1 
About this table        Species with no ortholog for IFNA2

ENSEMBL Gene Tree for IFNA2
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for IFNA2 gene
IFNA12  IFNA212  IFNA72  IFNA172  IFNA42  IFNA62  IFNA142  IFNA132  
IFNA162  IFNA102  IFNA82  IFNA52  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: IFNA2_HUMAN, P01563
Polymorphism: Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c


10/20 NCBI SNPs in IFNA2 are shown (see all 20 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 31)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs101209771,2
A,C,F,H21374363(+) ATTTCA/GTTTTA 1 -- ut317Minor allele frequency- G:0.10NA EU EA WA 562
rs6247041,2
A,C,F,H21373898(-) GGTGTC/TGGGAG 1 -- ng5111Minor allele frequency- T:0.46EU EA WA NA 922
--
rs10619591,2
C,F,H21375192(-) GAGGAG/AAATCT 1 K/R mis113Minor allele frequency- A:0.01MN EU EA WA 1416
--
rs6150771,2
C,F21373852(-) CTGAAG/CACCTT 1 -- ng513Minor allele frequency- C:0.01NA 142
--
rs359719161,2
C,F21375312(-) CTTTGC/ATTTAC 1 D/A mis15Minor allele frequency- A:0.02NA EU EA WA 468
rs169383691,2
F,H21375501(+) TATGCA/TCTCTT 1 -- ng317Minor allele frequency- T:0.06NA EU EA WA 562
rs132970881,2
H21375554(+) tattgT/Gttcct 1 -- ng31 trp34Minor allele frequency- G:0.00EU EA WA 420
rs123384181,2
H21375856(+) aataaG/Ttgaaa 1 -- ng314Minor allele frequency- T:0.00EU EA WA 414
--
rs617362531,2
--21374792(+) TGCAAC/TTTTGT 2 N/K mis10--------
--
rs6628311,2
--21376684(-) taaaaA/Gactaa 1 -- ng310--------
About this table

HapMap Linkage Disequilibrium images for IFNA2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147562

10/97 Novoseek disease relationships for IFNA2 gene (see all 97 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis c chronic 92.16 454 9382363 (6), 18020586 (5), 11772139 (4), 9563925 (3) (see all 99)
hepatitis c 82.42 173 7890902 (3), 1323873 (2), 8872767 (2), 11391241 (2) (see all 99)
hepatitis b chronic 79.24 122 7702228 (4), 11517899 (3), 12508364 (3), 15854180 (2) (see all 92)
metastatic renal cell carcinoma 76.33 51 8558634 (2), 10834025 (2), 2321276 (2), 7754540 (2) (see all 43)
hepatitis chronic active 76.13 43 8872767 (2), 7749499 (2), 8790569 (2), 7827383 (2) (see all 37)
stable disease 74.43 3 1795011 (1), 12710586 (1), 2001899 (1)
hepatitis chronic 72.22 30 10989698 (2), 1289187 (1), 17133585 (1), 18568137 (1) (see all 29)
delta hepatitis chronic 69.61 12 8188163 (2), 8586031 (1), 7839006 (1), 9696491 (1) (see all 10)
hepatitis b 68.04 78 7702228 (3), 2031078 (2), 2186494 (2), 8790569 (2) (see all 59)
hepatitis chronic non-a non-b 67.74 10 1362657 (2), 8244259 (2), 1909274 (1), 1953524 (1) (see all 8)
About this table

Human Gene Mutation Database: IFNA2
Human Genome Epidemiology Navigator: IFNA2 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/1343 PubMed articles for IFNA2 gene (see all 1343 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3440 HGNC: 5423 AceView: IFNA2 Ensembl:ENSG00000188379 euGenes: HUgn3440
ECgene: IFNA2 H-InvDB: IFNA2
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for IFNA2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IFNA2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for IFNA2 Antibodies for IFNA2
 Explore super-pooled esiRNAs Proteins for IFNA2
 Lentivirus-delivered shRNAs for IFNA2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (IFNA2)
 Antibodies (IFNA2)
 Chimera RNAi (IFNA2)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(Interferon alpha 2, Interferon alpha 2b, Interferon Alpha A+D)
 Antibodies (Interferon alpha 2, Interferon alpha 2b, Interferon Alpha A+D)
 Search OriGene for IFNA2
 Search Tocris compounds for IFNA2




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for IFNA2

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