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Aliases for IFNA2 Gene

Aliases for IFNA2 Gene

  • Interferon, Alpha 2 2 3
  • Alpha-2a Interferon 2 3
  • Interferon Alpha 2b 2 3
  • Interferon Alpha A 2 3
  • IFN-Alpha-2 3 4
  • LeIF A 3 4
  • IFNA2B 3 4
  • Interferon Alpha 2a 3
  • Interferon Alpha-2 3
  • Interferon Alpha-A 4
  • IFN-AlphaA 3
  • IFNA2A 4
  • IFNA2C 4
  • INFA2 3
  • IFNA 3

External Ids for IFNA2 Gene

Previous GeneCards Identifiers for IFNA2 Gene

  • GC09M021711
  • GC09M021585

Summaries for IFNA2 Gene

Entrez Gene Summary for IFNA2 Gene

  • This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]

GeneCards Summary for IFNA2 Gene

IFNA2 (Interferon, Alpha 2) is a Protein Coding gene. Diseases associated with IFNA2 include bronchiolitis obliterans organizing pneumonia and cutaneous t cell lymphoma. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA2 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities

Gene Wiki entry for IFNA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA2 Gene

Genomics for IFNA2 Gene

Regulatory Elements for IFNA2 Gene

Genomic Location for IFNA2 Gene

Start:
21,384,254 bp from pter
End:
21,385,397 bp from pter
Size:
1,144 bases
Orientation:
Minus strand

Genomic View for IFNA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA2 Gene

Proteins for IFNA2 Gene

  • Protein details for IFNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01563-IFNA2_HUMAN
    Recommended name:
    Interferon alpha-2
    Protein Accession:
    P01563
    Secondary Accessions:
    • H2DF54
    • H2DF55
    • P01564
    • Q14606
    • Q6DJX8
    • Q96KI6

    Protein attributes for IFNA2 Gene

    Size:
    188 amino acids
    Molecular mass:
    21550 Da
    Quaternary structure:
    • Interacts with IFNAR2.

    Three dimensional structures from OCA and Proteopedia for IFNA2 Gene

neXtProt entry for IFNA2 Gene

Proteomics data for IFNA2 Gene at MOPED

Post-translational modifications for IFNA2 Gene

  • Glycosylation at Thr129
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for IFNA2 Gene

Domains for IFNA2 Gene

Gene Families for IFNA2 Gene

HGNC:
  • IFN :Interferons

Suggested Antigen Peptide Sequences for IFNA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01563

UniProtKB/Swiss-Prot:

IFNA2_HUMAN :
  • P01563
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA2: view

Function for IFNA2 Gene

Molecular function for IFNA2 Gene

GENATLAS Biochemistry: interferon type I,alpha 2,leukocyte
UniProtKB/Swiss-Prot Function: Produced by macrophages, IFN-alpha have antiviral activities

Gene Ontology (GO) - Molecular Function for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding TAS 6158094
GO:0005515 protein binding IPI 7759950
genes like me logo Genes that share ontologies with IFNA2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNA2 Gene

Localization for IFNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA2 Gene COMPARTMENTS Subcellular localization image for IFNA2 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IFNA2: view

Pathways for IFNA2 Gene

genes like me logo Genes that share pathways with IFNA2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antiviral Response in human,mouse,rat
    • Apoptosis 384HT in human,mouse,rat
    • Common Cytokines in human,mouse,rat
    • Cytokines & Chemokines in human,mouse,rat
    • Inflammatory Cytokines & Receptors in human,mouse,rat

Gene Ontology (GO) - Biological Process for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10477584
GO:0006952 defense response --
GO:0006954 inflammatory response TAS 10477584
GO:0007166 cell surface receptor signaling pathway TAS 6158094
GO:0007267 cell-cell signaling TAS 10477584
genes like me logo Genes that share ontologies with IFNA2: view

Compounds for IFNA2 Gene

UniProtKB/Swiss-Prot:

P01563-IFNA2_HUMAN
Pharmaceutical: Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer drug for its antiproliferative activity

(137) Novoseek inferred chemical compound relationships for IFNA2 Gene

Compound -log(P) Hits PubMed IDs
ribavirin 91.7 214
intron a 86.1 28
pegasys 80 13
ifn-alpha 77.3 27
dacarbazine 75.7 43
genes like me logo Genes that share compounds with IFNA2: view

Transcripts for IFNA2 Gene

mRNA/cDNA for IFNA2 Gene

(7) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA2 Gene

No ASD Table

Relevant External Links for IFNA2 Gene

GeneLoc Exon Structure for
IFNA2
ECgene alternative splicing isoforms for
IFNA2

Expression for IFNA2 Gene

mRNA expression in normal human tissues for IFNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IFNA2 Gene

SOURCE GeneReport for Unigene cluster for IFNA2 Gene Hs.211575

genes like me logo Genes that share expressions with IFNA2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFNA2 Gene

Orthologs for IFNA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA2 35
  • 99.65 (n)
  • 98.94 (a)
IFNA2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
IFNAA 36
  • 61 (a)
ManyToMany
IFNAG 36
  • 62 (a)
ManyToMany
IFNAG 36
  • 62 (a)
ManyToMany
IFNAH 36
  • 61 (a)
ManyToMany
INFAF 36
  • 61 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 36
  • 60 (a)
ManyToMany
Gm13280 36
  • 61 (a)
ManyToMany
Ifna1 36
  • 61 (a)
ManyToMany
Ifna11 36
  • 58 (a)
ManyToMany
Ifna12 36
  • 62 (a)
ManyToMany
Ifna13 36
  • 61 (a)
ManyToMany
Ifna14 36
  • 60 (a)
ManyToMany
Ifna2 36
  • 58 (a)
ManyToMany
Ifna4 36
  • 56 (a)
ManyToMany
Ifna5 36
  • 62 (a)
ManyToMany
Ifna6 36
  • 61 (a)
ManyToMany
Ifna7 36
  • 57 (a)
ManyToMany
Ifna9 36
  • 60 (a)
ManyToMany
Ifnab 36
  • 58 (a)
ManyToMany
Species with no ortholog for IFNA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA2 Gene

ENSEMBL:
Gene Tree for IFNA2 (if available)
TreeFam:
Gene Tree for IFNA2 (if available)

Paralogs for IFNA2 Gene

Selected SIMAP similar genes for IFNA2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for IFNA2 Gene

genes like me logo Genes that share paralogs with IFNA2: view

Variants for IFNA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA2 Gene

P01563-IFNA2_HUMAN
Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c

Sequence variations from dbSNP and Humsavar for IFNA2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs615077 -- 21,383,853(-) CTGAA(C/G)ACCTT downstream-variant-500B
rs624704 -- 21,383,899(-) GGTGT(C/T)GGGAG downstream-variant-500B
rs625082 -- 21,383,854(-) TCTGA(A/G)CACCT downstream-variant-500B
rs662831 -- 21,386,685(-) taaaa(A/G)actaa upstream-variant-2KB
rs674189 -- 21,386,289(-) ggcta(A/G)gtagt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNA2 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892736 CNV Gain 21882294
nsv892737 CNV Loss 21882294
esv2752289 CNV Gain 17911159
nsv892738 CNV Gain 21882294

Relevant External Links for IFNA2 Gene

HapMap Linkage Disequilibrium report
IFNA2
Human Gene Mutation Database (HGMD)
IFNA2

Disorders for IFNA2 Gene

(98) Novoseek inferred disease relationships for IFNA2 Gene

Disease -log(P) Hits PubMed IDs
hepatitis c chronic 92.4 190
hepatitis c 83.1 116
hepatitis b chronic 79.4 116
metastatic renal cell carcinoma 76.5 56
hepatitis chronic active 76.2 44

Relevant External Links for IFNA2

Genetic Association Database (GAD)
IFNA2
Human Genome Epidemiology (HuGE) Navigator
IFNA2
genes like me logo Genes that share disorders with IFNA2: view

No data available for UniProtKB/Swiss-Prot for IFNA2 Gene

Publications for IFNA2 Gene

  1. Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. (PMID: 8994971) Radhakrishnan R. … Walter M.R. (Structure 1996) 3 4 23
  2. Genetic association of interferon-alpha subtypes 1, 2 and 5 in systemic lupus erythematosus. (PMID: 19000144) Hirankarn N. … Avihingsanon Y. (Tissue Antigens 2008) 3 23 48
  3. Serum concentrations of pegylated interferon alpha-2b in patients with resected stage III melanoma receiving adjuvant pegylated interferon alpha-2b in a randomized phase III trial (EORTC 18991). (PMID: 19621225) Eggermont A.M. … Xu C. (Cancer Chemother. Pharmacol. 2010) 3 23
  4. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  5. Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli. (PMID: 3906813) Oliver G. … Bolivar F. (Rev. Latinoam. Microbiol. 1985) 3 4

Products for IFNA2 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antiviral Response in human,mouse,rat
    • Apoptosis 384HT in human,mouse,rat
    • Common Cytokines in human,mouse,rat
    • Cytokines & Chemokines in human,mouse,rat
    • Inflammatory Cytokines & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNA2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA2
  • Block miRNA regulation of IFNA2 using miScript Target Protectors
  • antibodies-online proteins for IFNA2
  • antibodies-online antibodies for IFNA2
  • antibodies-online kits for IFNA2

Sources for IFNA2 Gene

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