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Aliases for IFNA17 Gene

Aliases for IFNA17 Gene

  • Interferon, Alpha 17 2 3
  • Interferon Alpha-88 3 4
  • Interferon Alpha-I 3 4
  • Interferon Alpha-T 3 4
  • IFN-Alpha-17 3 4
  • LeIF I 3 4
  • Interferon Alpha-WA 3
  • Interferon Alpha-17 3
  • IFN-AlphaI 3
  • LEIF2C1 3
  • IFNA 3
  • INFA 3

External Ids for IFNA17 Gene

Previous GeneCards Identifiers for IFNA17 Gene

  • GC09M021554
  • GC09M021428
  • GC09M021217
  • GC09M021227

Summaries for IFNA17 Gene

GeneCards Summary for IFNA17 Gene

IFNA17 (Interferon, Alpha 17) is a Protein Coding gene. Diseases associated with IFNA17 include pulmonary sarcoidosis and dengue hemorrhagic fever. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA17 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA17 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA17 Gene

Genomics for IFNA17 Gene

Regulatory Elements for IFNA17 Gene

Transcription factor binding sites by QIAGEN in the IFNA17 gene promoter:

Genomic Location for IFNA17 Gene

Start:
21,206,528 bp from pter
End:
21,228,222 bp from pter
Size:
21,695 bases
Orientation:
Minus strand

Genomic View for IFNA17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNA17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA17 Gene

Proteins for IFNA17 Gene

  • Protein details for IFNA17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01571-IFN17_HUMAN
    Recommended name:
    Interferon alpha-17
    Protein Accession:
    P01571
    Secondary Accessions:
    • Q14639
    • Q4KMT4
    • Q5VZ53
    • Q7M4Q4

    Protein attributes for IFNA17 Gene

    Size:
    189 amino acids
    Molecular mass:
    21728 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA17 Gene

Proteomics data for IFNA17 Gene at MOPED

Post-translational modifications for IFNA17 Gene

No Post-translational modifications

Other Protein References for IFNA17 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA17 Gene

Domains for IFNA17 Gene

Gene Families for IFNA17 Gene

HGNC:
  • IFN :Interferons

Suggested Antigen Peptide Sequences for IFNA17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01571

UniProtKB/Swiss-Prot:

IFN17_HUMAN :
  • P01571
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA17: view

Function for IFNA17 Gene

Molecular function for IFNA17 Gene

GENATLAS Biochemistry: interferon type I,alpha 17,leukocyte
UniProtKB/Swiss-Prot Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA17: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA17

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNA17 Gene

Localization for IFNA17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA17 Gene COMPARTMENTS Subcellular localization image for IFNA17 gene
Compartment Confidence
extracellular 5
chloroplast 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for IFNA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA17: view

Pathways for IFNA17 Gene

genes like me logo Genes that share pathways with IFNA17: view

Gene Ontology (GO) - Biological Process for IFNA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA17: view

Transcripts for IFNA17 Gene

mRNA/cDNA for IFNA17 Gene

(1) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA17

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IFNA17
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA17 Gene

No ASD Table

Relevant External Links for IFNA17 Gene

GeneLoc Exon Structure for
IFNA17
ECgene alternative splicing isoforms for
IFNA17

Expression for IFNA17 Gene

mRNA expression in normal human tissues for IFNA17 Gene

SOURCE GeneReport for Unigene cluster for IFNA17 Gene Hs.282276

genes like me logo Genes that share expressions with IFNA17: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for IFNA17 Gene

Orthologs for IFNA17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
LOC473191 35
  • 98.41 (n)
  • 96.3 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
IFNAA 36
  • 61 (a)
ManyToMany
IFNAG 36
  • 62 (a)
ManyToMany
IFNAG 36
  • 63 (a)
ManyToMany
IFNAH 36
  • 63 (a)
ManyToMany
INFAF 36
  • 61 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 36
  • 60 (a)
ManyToMany
Gm13280 36
  • 60 (a)
ManyToMany
Ifna1 36
  • 60 (a)
ManyToMany
Ifna11 36
  • 57 (a)
ManyToMany
Ifna12 36
  • 60 (a)
ManyToMany
Ifna13 36
  • 60 (a)
ManyToMany
Ifna14 36
  • 58 (a)
ManyToMany
Ifna2 36
  • 57 (a)
ManyToMany
Ifna4 36
  • 56 (a)
ManyToMany
Ifna5 36
  • 60 (a)
ManyToMany
Ifna6 36
  • 60 (a)
ManyToMany
Ifna7 36
  • 57 (a)
ManyToMany
Ifna9 36
  • 59 (a)
ManyToMany
Ifnab 36
  • 58 (a)
ManyToMany
Species with no ortholog for IFNA17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA17 Gene

ENSEMBL:
Gene Tree for IFNA17 (if available)
TreeFam:
Gene Tree for IFNA17 (if available)

Paralogs for IFNA17 Gene

Selected SIMAP similar genes for IFNA17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA17: view

Variants for IFNA17 Gene

Sequence variations from dbSNP and Humsavar for IFNA17 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1062561 -- 21,228,189(-) AGCAA(C/T)ATTTG utr-variant-5-prime
rs1062583 -- 21,227,539(-) AGTTC(C/T)TCCAT utr-variant-3-prime
rs1062585 -- 21,227,504(-) CCACG(A/C)GTTGA utr-variant-3-prime
rs1062587 -- 21,227,433(-) CTAGT(A/C)CTTTA utr-variant-3-prime
rs1139501 -- 21,227,392(-) tattt(A/G)tttaa utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IFNA17 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294
esv2738277 CNV Deletion 23290073
esv2738279 CNV Deletion 23290073

Relevant External Links for IFNA17 Gene

HapMap Linkage Disequilibrium report
IFNA17
Human Gene Mutation Database (HGMD)
IFNA17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA17 Gene

Disorders for IFNA17 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for IFNA17 Gene including...

Search for IFNA17 Gene in MalaCards »

(2) University of Copenhagen DISEASES for IFNA17 Gene

Relevant External Links for IFNA17

Genetic Association Database (GAD)
IFNA17
Human Genome Epidemiology (HuGE) Navigator
IFNA17
genes like me logo Genes that share disorders with IFNA17: view

No data available for UniProtKB/Swiss-Prot for IFNA17 Gene

Publications for IFNA17 Gene

  1. Interferon, alpha 17 (IFNA17) Ile184Arg polymorphism and cervical cancer risk. (PMID: 12490311) Kim J.W. … Lee H.P. (Cancer Lett. 2003) 3 23 48
  2. Association between IFNA genotype and the risk of sarcoidosis. (PMID: 15004750) Akahoshi M. … Shirakawa T. (Hum. Genet. 2004) 3 23 48
  3. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  4. Purification and characterization of multiple components of human lymphoblastoid interferon-alpha. (PMID: 1634550) Zoon K.C. … Hu R.-Q. (J. Biol. Chem. 1992) 3 4
  5. A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population. (PMID: 9712362) Hussain M. … Liao M.-J. (J. Interferon Cytokine Res. 1998) 3 4

Products for IFNA17 Gene

Sources for IFNA17 Gene

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