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Aliases for IFNA17 Gene

Aliases for IFNA17 Gene

  • Interferon, Alpha 17 2 3 5
  • Interferon Alpha-88 3 4
  • Interferon Alpha-I 3 4
  • Interferon Alpha-T 3 4
  • IFN-Alpha-17 3 4
  • LeIF I 3 4
  • Interferon Alpha-WA 3
  • IFN-AlphaI 3
  • LEIF2C1 3
  • IFNA 3
  • INFA 3

External Ids for IFNA17 Gene

Previous GeneCards Identifiers for IFNA17 Gene

  • GC09M021554
  • GC09M021428
  • GC09M021217
  • GC09M021254
  • GC09M021259

Summaries for IFNA17 Gene

GeneCards Summary for IFNA17 Gene

IFNA17 (Interferon, Alpha 17) is a Protein Coding gene. Diseases associated with IFNA17 include Croup. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Allograft rejection. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA17 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA17 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA17 Gene

Genomics for IFNA17 Gene

Regulatory Elements for IFNA17 Gene

Transcription factor binding sites by QIAGEN in the IFNA17 gene promoter:

Genomic Location for IFNA17 Gene

21,227,243 bp from pter
21,228,222 bp from pter
980 bases
Minus strand

Genomic View for IFNA17 Gene

Genes around IFNA17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA17 Gene

Proteins for IFNA17 Gene

  • Protein details for IFNA17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-17
    Protein Accession:
    Secondary Accessions:
    • Q14639
    • Q4KMT4
    • Q5VZ53
    • Q7M4Q4

    Protein attributes for IFNA17 Gene

    189 amino acids
    Molecular mass:
    21728 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA17 Gene

Proteomics data for IFNA17 Gene at MOPED

Post-translational modifications for IFNA17 Gene

No Post-translational modifications

Other Protein References for IFNA17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA17 Gene

Domains & Families for IFNA17 Gene

Gene Families for IFNA17 Gene

Suggested Antigen Peptide Sequences for IFNA17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA17: view

Function for IFNA17 Gene

Molecular function for IFNA17 Gene

GENATLAS Biochemistry:
interferon type I,alpha 17,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Phenotypes for IFNA17 Gene

genes like me logo Genes that share phenotypes with IFNA17: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA17 Gene

Localization for IFNA17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA17 Gene


Subcellular locations from

Jensen Localization Image for IFNA17 Gene COMPARTMENTS Subcellular localization image for IFNA17 gene
Compartment Confidence
extracellular 5
chloroplast 3
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for IFNA17 Gene

Pathways & Interactions for IFNA17 Gene

genes like me logo Genes that share pathways with IFNA17: view

Gene Ontology (GO) - Biological Process for IFNA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
GO:0007596 blood coagulation TAS --
GO:0009615 response to virus TAS 3891272
genes like me logo Genes that share ontologies with IFNA17: view

No data available for SIGNOR curated interactions for IFNA17 Gene

Drugs & Compounds for IFNA17 Gene

No Compound Related Data Available

Transcripts for IFNA17 Gene

mRNA/cDNA for IFNA17 Gene

(1) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA17 Gene

No ASD Table

Relevant External Links for IFNA17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA17 Gene

mRNA expression in normal human tissues for IFNA17 Gene

SOURCE GeneReport for Unigene cluster for IFNA17 Gene Hs.282276

genes like me logo Genes that share expression patterns with IFNA17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFNA17 Gene

Orthologs for IFNA17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC473191 35
  • 98.41 (n)
  • 96.3 (a)
-- 36
  • 97 (a)
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
-- 36
  • 62 (a)
-- 36
  • 63 (a)
-- 36
  • 62 (a)
-- 36
  • 61 (a)
  • 61 (a)
  • 62 (a)
  • 63 (a)
  • 63 (a)
  • 61 (a)
(Mus musculus)
Mammalia Gm12597 36
  • 60 (a)
Gm13280 36
  • 60 (a)
Ifna1 36
  • 60 (a)
Ifna11 36
  • 57 (a)
Ifna12 36
  • 60 (a)
Ifna13 36
  • 60 (a)
Ifna14 36
  • 58 (a)
Ifna2 36
  • 57 (a)
Ifna4 36
  • 56 (a)
Ifna5 36
  • 60 (a)
Ifna6 36
  • 60 (a)
Ifna7 36
  • 57 (a)
Ifna9 36
  • 59 (a)
Ifnab 36
  • 58 (a)
Species with no ortholog for IFNA17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA17 Gene

Gene Tree for IFNA17 (if available)
Gene Tree for IFNA17 (if available)

Paralogs for IFNA17 Gene

(19) SIMAP similar genes for IFNA17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA17: view

Variants for IFNA17 Gene

Sequence variations from dbSNP and Humsavar for IFNA17 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs9298814 - 21,227,623(-) AAAAA(C/G/T)ATTAA reference, missense
rs1062561 -- 21,228,189(-) AGCAA(C/T)ATTTG utr-variant-5-prime
rs1062583 -- 21,227,539(-) AGTTC(C/T)TCCAT utr-variant-3-prime
rs1062585 -- 21,227,504(-) CCACG(A/C)GTTGA utr-variant-3-prime
rs1062587 -- 21,227,433(-) CTAGT(A/C)CTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IFNA17 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294
esv2738277 CNV Deletion 23290073
esv2738279 CNV Deletion 23290073

Variation tolerance for IFNA17 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA17 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA17 Gene

Disorders for IFNA17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNA17 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • acute laryngotracheobronchitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IFNA17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IFNA17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA17 Gene

Publications for IFNA17 Gene

  1. Association between IFNA genotype and the risk of sarcoidosis. (PMID: 15004750) Akahoshi M. … Shirakawa T. (Hum. Genet. 2004) 3 23 48 67
  2. Interferon, alpha 17 (IFNA17) Ile184Arg polymorphism and cervical cancer risk. (PMID: 12490311) Kim J.W. … Lee H.P. (Cancer Lett. 2003) 3 23
  3. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  4. HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms. (PMID: 25972534) Reszka-Blanco N.J. … Su L. (J. Virol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for IFNA17 Gene

Sources for IFNA17 Gene