IFNA17 Gene
protein-coding GIFtS: 52
GCID: GC09M021227
|
|
interferon, alpha 17
| |
Aliases
for IFNA17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon, Alpha 171 2 | | LeIF I2 3 | | IFN-AlphaI1 | | IFN-Alpha-171 | | LEIF2C11 2 | | IFNA2 | | Interferon Alpha-882 3 | | INFA2 | | Interferon Alpha-I'2 3 | | Interferon Alpha-172 | | Interferon Alpha-T2 3 | | Interferon Alpha-WA2 |
Export aliases for IFNA17 gene to outside databasesPrevious GC identifers: GC09M021554 GC09M021428 GC09M021217 |
Summaries
for IFNA17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IFN17_HUMAN, P01571Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase
Gene Wiki entry for IFNA17
|
Genomic Views
for IFNA17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFNA17 gene promoter:
Egr-3 Egr-2 Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFNA17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22IFNA17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M021227: view genomic region
(about GC identifiers)
Start:
|
21,227,242 bp from pter |
End:
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21,228,221 bp from pter |
Size:
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980 bases |
Orientation:
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minus strand |
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Proteins
for IFNA17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFN17_HUMAN, P01571 (See
protein sequence)Recommended Name: Interferon alpha-17 precursor Size: 189 amino acids; 21728 Da
Subcellular location: Secreted
Secondary accessions: Q14639 Q4KMT4 Q5VZ53 Q7M4Q4Explore the universe of human proteins at neXtProt for IFNA17: NX_P01571
IFNA17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_067091.1
ENSEMBL proteins: ENSP00000411940 Reactome Protein details: P01571
Human Recombinant Protein Products for IFNA17:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005615 | extracellular space |
IEA | -- |
IFNA17 for ontologies About GeneDecksing
IFNA17 Antibody Products:
Assay Products for IFNA17: |
Protein
Domains /
Families
for IFNA17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFNA17 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P01571ProtoNet protein and cluster: P01571 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFN17_HUMAN, P01571Similarity: Belongs to the alpha/beta interferon family |
Function
for IFNA17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IFN17_HUMAN, P01571Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase Genatlas biochemistry entry for IFNA17:interferon type I,alpha 17,leukocyte
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
IFNA17 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA17
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNA17 (NM_021268) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA17 |
|
Pathways & Interactions
for IFNA17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of IFNA signaling | | | 2 | Toll-like receptor signaling pathway | | | 3 | Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway | | | 4 | Cytokine Signaling in Immune system | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for IFNA17
1  R&D Systems Pathway for IFNA17
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA17
2  GeneGo (Thomson Reuters) Pathways for IFNA17
1  BioSystems Pathway for IFNA17
5/11 
Reactome Pathways for IFNA17 (see all 11)
5/12 
Kegg Pathways (Kegg details for IFNA17) (see all 12):
IFNA17 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA17
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for IFNA17 (ENSP000004119404) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
IFNA17 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFNA17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFNA17
Search CenterWatch for drugs/clinical trials and news about IFNA17 / IFN17
|
Transcripts
for IFNA17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFNA17 gene: NM_021268.2 Unigene Cluster for IFNA17: Interferon, alpha 17 Hs.282276 Unigene Representative Sequence: M110261 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000413767(uc003zos.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA17
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IFNA17 (NM_021268) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA17 |
Additional cDNA sequence: BC096732.1 BC098355.1 M11026.1 M38289.1 M71246.1 1 DOTS entry: DT.121210182 10 AceView cDNA sequences: NM_021268 BV199643 M71246 M38289 M11026 BV199641 BV199633 BV199638 BV199640 BV199631
GeneLoc Exon Structure
|
Expression
for IFNA17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFNA17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IFNA17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA17
SOURCE GeneReport for Unigene cluster: Hs.282276
SABiosciences Custom PCR Arrays for IFNA17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA17
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IFNA17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA17 |
Orthologs
for IFNA17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFNA17 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for IFNA17 (if available)
TreeFam Gene Tree for IFNA17 (if available) |
Paralogs
for IFNA17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IFNA17 gene
- IFNA72 IFNA22 IFNE2 IFNA42 IFNA142 IFNK2 IFNA52 IFNA12
- IFNA212 IFNA62 IFNB12 IFNA132 IFNW12 IFNA162 IFNA102 IFNA82
18/19 SIMAP similar genes for IFNA17 using alignment to 1 protein entry: IFN17_HUMAN(see all similar genes):IFNA4 IFNA10 IFNA21 IFNA5 IFNA7 IFNA14
IFNA16 IFNA IFN-2 IFNA2 IFNA2B IFNA1
IFNA13 IFNA6 IFNA8 IFNW1 IFNB1 IFNE
IFNA17 for paralogs About GeneDecksing
|
Genomic Variants
for IFNA17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFNA17 (21227242 - 21228221 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFNA17: --
Human Gene Mutation Database (HGMD): IFNA17
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA17 |
|
Disorders
/ Diseases
for IFNA17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFNA17 for disorders About GeneDecksing
OMIM gene information: 147583
OMIM disorders: --
20  diseases for IFNA17: About MalaCardsdengue hemorrhagic fever hemorrhagic fever systemic lupus erythematosus lupus erythematosus
pulmonary sarcoidosis sarcoidosis cystic fibrosis autoimmune thyroiditis
multiple sclerosis hepatitis c hepatitis b measles
fibrosis cervical cancer cervicitis hepatitis
influenza thyroiditis tuberculosis melanoma
2 diseases from the University of Copenhagen DISEASES database for IFNA17:Hepatitis C Hepatitis B Genetic Association Database (GAD): IFNA17
Human Genome Epidemiology (HuGE) Navigator: IFNA17 (8 documents)
Export disorders for IFNA17 gene to outside databases
|
Publications
for IFNA17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFNA17 gene, integrated from 9 sources (see all 71):
(articles sorted by number of sources associating them with IFNA17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association between IFNA genotype and the risk of sarcoidosis. (PubMed id 15004750)1, 4, 9 Akahoshi M....Shirakawa T. (2004)
- Interferon, alpha 17 (IFNA17) Ile184Arg polymorphism and cervical cancer risk. (PubMed id 12490311)1, 4, 9 Kim J.W....Lee H.P. (2003)
- A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population. (PubMed id 9712362)1, 2 Hussain M.... Liao M.-J. (1998)
- Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (1998)
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
- Purification and characterization of multiple components of human lymphoblastoid interferon-alpha. (PubMed id 1634550)1, 2 Zoon K.C.... Hu R.-Q. (1992)
- [Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons]. (PubMed id 3767336)1, 2 Saveliev V.I.... Sverdlov E.D. (1986)
- Differential expression of interferon genes in a substrain of Namalwa cells. (PubMed id 4008999)1, 2 Lund B.... Lundgren E. (1985)
- Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules. (PubMed id 3891272)1, 2 Mizoguchi J.... Raj N.B.K. (1985)
- DNA sequence of two closely linked human leukocyte interferon genes. (PubMed id 6165082)1, 2 Lawn R.M.... Ullrich A. (1981)
|
External Searches for IFNA17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFNA17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFNA17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNA17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFNA17 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IFNA17 gene:
Search GeneIP for patents involving IFNA17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFNA17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IFNA17 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNA17 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA17 | | | OriGene Protein Over-expression Lysate for IFNA17 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IFNA17 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA17 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA17 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IFNA17 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IFNA17 | | OriGene Custom Protein Services for IFNA17 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNA17 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA17 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA17 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA17 |
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 | | | | |  |  |  |  | | | | Search ThermoFisher Antibodies for IFNA17 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA17 |
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