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IFNA17 Gene

protein-coding GIFtS: 57

GC09M021217

interferon, alpha 17
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
IFNA ^²
INFA ^²
LEIF2C1 ^¹, ²
OTTHUMP00000021140 ^²

Descriptions
Interferon alpha-88 ^³
Interferon alpha-I' ^³
Interferon alpha-T ^³
LeIF I ^³
interferon alpha-WA ^²
interferon, alpha 17 ^²

External Ids
HGNC: 5422¹
Entrez Gene: 3451²
UniProtKB: P01571³
Ensembl: ENSG00000214040⁷

Search outside databases for aliases for IFNA17 gene

Previous GC identifers: GC09M021554 GC09M021428

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: IFN17_HUMAN, P01571

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the

production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA17

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IFNA17 gene

Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22

IFNA17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M021217: (about GC identifiers)

Start:	21,217,242 bp from pter
End:	21,218,221 bp from pter
Size:	980 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFN17_HUMAN, P01571 (See protein sequence)

Recommended Name: Interferon alpha-17 precursor

Size: 189 amino acids; 21728 Da

Subcellular location: Secreted

Secondary accessions: Q14639 Q4KMT4 Q5VZ53 Q7M4Q4

REFSEQ proteins: NP_067091.1

ENSEMBL proteins:

ENSP00000369562

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IFNA17 (IFN-alpha I, IFN-alpha WA)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IFNA17)
	Human Recombinant Proteins from Abnova (IFNA17)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for IFNA17:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IFNA17), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IFNA17)
	Novus Biologicals Antibodies for IFNA17

Assays for IFNA17:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01571

ProtoNet protein and cluster: P01571

1 Blocks protein family: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFN17_HUMAN, P01571

Similarity: Belongs to the alpha/beta interferon family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021268

Applied Biosystems Silencer® siRNAs for IFNA17

Sigma-Aldrich siRNA for IFNA17

Sigma-Aldrich shRNA Panels and shRNA for IFNA17

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IFNA17
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_021268
Myc/DDK tagged cDNA clone in CMV expression vector: NM_021268
untagged cDNA clone in CMV expression vector: NM_021268

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021268

UniProtKB/Swiss-Prot: IFN17_HUMAN, P01571

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the

production of two enzymes: a protein kinase and an oligoadenylate synthetase

Genatlas biochemistry entry for IFNA17:

interferon type I,alpha 17,leukocyte

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005132	interferon-alpha/beta receptor binding	TAS	3891272

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for IFNA17 (Your Favorite Gene powered by Ingenuity)

IL-12 Signaling and Production in Macrophages
Role of Cytokines in Mediating Communication between Immune Cells
Activation of IRF by Cytosolic Pattern Recognition Receptors
Role of RIG1-like Receptors in Antiviral Innate Immunity

GeneDecks IFNA17 for the pathways selected above

About GeneDecksing

5/63 Interacting proteins for IFNA17 (ENSP00000369562³) via UniProtKB, MINT, and/or STRING (see all 63 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IFNG	ENSP00000229135³	STRING (score=.997)
IFNAR2	ENSP00000371676³	STRING (score=.991)
STAT2	ENSP00000315768³	STRING (score=.96)
IFNGR2	ENSP00000371425³	STRING (score=.956)
IRF3	ENSP00000310127³	STRING (score=.929)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006952	defense response	IEA	--
GO:0009615	response to virus	TAS	3891272

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFNA17

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021268

Sigma-Aldrich siRNA for IFNA17

Sigma-Aldrich shRNA Panels and shRNA for IFNA17

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021268

REFSEQ mRNAs for IFNA17 gene:

NM_021268.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021268

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021268
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021268
                                 untagged cDNA clone in CMV expression vector: NM_021268

Additional cDNA sequence:

BC096732.1 BC098355.1 M11026.1 M38289.1 M71246.1

1 DOTS entry:

DT.121210182

10 AceView cDNA sequences:

BV199643 M11026 M71246 NM_021268 M38289 BV199638 BV199640 BV199641

BV199633 BV199631

highest scoring ESTs for IFNA17:

M11026 M38289 M71246 BC096732 BC098355 NM_021268 J00209

Unigene Cluster for IFNA17:

Interferon, alpha 17

Hs.282276

Unigene Representative Sequence: M11026

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000380214

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFNA17 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFNA17

¹ / ² / ³

5 probe-sets matching IFNA17 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
427_f_at²^{, 3}	U95-A	15	0.88	0.20	1.00	1.00	V00551	0.40	0.30	0.35	2
211405_x_at²^{, 3}	U133-A	13	1.00	0.17	--	--	M38289	0.80	1.00	0.91	1
207964_x_at²^{, 3}	U133-A	13	0.82	0.13	--	--	NM_021068	0.20	0.33	0.27	2
211405_x_at²	U133Plus2	13	1.00	0.17	--	--	--	--	--	--	--
207964_x_at²	U133Plus2	13	0.82	0.13	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.282276

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IFNA17 gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC473191¹	--	similar to interferon-alpha	98.59(n) 96.3(a)	473191 XM_001152078.1 XP_001152078.1

About this table Species with no ortholog for IFNA17

ENSEMBL Gene Tree for IFNA17

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IFNA17 gene

IFNA1² IFNA21² IFNA2² IFNA7² IFNA6² IFNA4² IFNA14² IFNA13²

IFNA16² IFNA10² IFNA8² IFNA5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/34 NCBI SNPs in IFNA17 are shown (see all 34 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 7)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs10964918^1,2	A,C,F,H	21218285(+)	`TACTAA/GTTTCC`	1	--	ng3¹		2		EU WA	222
--	rs9298814^1,2	A,C,F,H	21217622(-)	`AAAAAT/GATTAA`	1	R/I	mis¹		6		NS EU EA WA MN	1988
--	rs1831391^1,2	A,F,H	21219327(+)	`ACATAA/CACTAC`	1	--	ng3¹		4		EU EA WA	376
--	rs10964920^1,2	A,F,H	21219184(+)	`GTTTAC/TCTTCA`	1	--	ng3¹		4		EU EA WA	418
--	rs7857863^1,2	A,C	21218378(+)	`TCATTG/TTTTTT`	1	--	ng3¹		0	--	--	--	--
--	rs7858057^1,2	A,C	21218765(+)	`aaataA/Tgaatc`	1	--	ng3¹		0	--	--	--	--
--	rs7868588^1,2	A,C	21217086(+)	`ATATCC/TTGAAG`	1	--	ng5¹		0	--	--	--	--
--	rs10757201^1,2	A,C	21218182(+)	`ATGTTG/TCAAAT`	1	--	ut5¹		0	--	--	--	--
--	rs7858431^1,2	A,C	21218987(+)	`tctacA/Caaaca`	1	--	ng3¹		0	--	--	--	--
--	rs10757202^1,2	A,C	21218183(+)	`TGTTGC/GAAATG`	1	--	ut5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for IFNA17 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147583

Human Gene Mutation Database: IFNA17
Genetic Association Database: IFNA17
Human Genome Epidemiology Navigator: IFNA17 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/20 PubMed articles for IFNA17 gene (see all 20 ):

Association between IFNA genotype and the risk of sarcoidosis. (PubMed id 15004750)^{1, 3, 6} Akahoshi M....Shirakawa T. (2004)
Interferon, alpha 17 (IFNA17) Ile184Arg polymorphism and cervical cancer risk. (PubMed id 12490311)^{1, 3, 6} Kim J.W....Lee H.P. (2003)
Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)^{3, 4} Nyman T.A.... Kalkkinen N. (1998)
A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population. (PubMed id 9712362)^{3, 4} Hussain M.... Liao M.-J. (1998)
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)^{2, 3} Olopade O.I....Diaz M.O. (1992)
Purification and characterization of multiple components of human lymphoblastoid interferon-alpha. (PubMed id 1634550)^{3, 4} Zoon K.C.... Hu R.Q. (1992)
[Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons]. (PubMed id 3767336)^{3, 4} Saveliev V.I.... Sverdlov E.D. (1986)
Differential expression of interferon genes in a substrain of Namalwa cells. (PubMed id 4008999)^{3, 4} Lund B.... Lundgren E. (1985)
Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules. (PubMed id 3891272)^{3, 4} Mizoguchi J.... Raj N.B.K. (1985)
DNA sequence of two closely linked human leukocyte interferon genes. (PubMed id 6165082)^{3, 4} Lawn R.M.... Ullrich A. (1981)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3451	HGNC: 5422	AceView: IFNA17	Ensembl:ENSG00000214040	euGenes: HUgn3451
ECgene: IFNA17	H-InvDB: IFNA17

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IFNA17
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IFNA17:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFNA17-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IFNA17		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IFNA17		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Tocris compounds for IFNA17

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IFNA17

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IFNA17 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for IFNA17

Summaries
for IFNA17

Genomic Location
for IFNA17

Proteins
for IFNA17

Protein Domains/
Families
for IFNA17

Gene Function
for IFNA17

Pathways & Interactions
for IFNA17

Drugs & Compounds
for IFNA17

Transcripts
for IFNA17

Expression
for IFNA17

Orthologs
for IFNA17

Paralogs
for IFNA17

SNPs/Variants
for IFNA17

Disorders & Mutations
for IFNA17

Medical News
for IFNA17

Publications
for IFNA17

Search for IFNA17

Genome Databases showing IFNA17

Other Databases showing IFNA17

Specialized Databases showing IFNA17

Licensable Technologies
for IFNA17

Services
for IFNA17

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFNA17 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor IFNA17

Summariesfor IFNA17

Genomic Locationfor IFNA17

Proteinsfor IFNA17

Protein Domains/Familiesfor IFNA17

Gene Functionfor IFNA17

Pathways & Interactionsfor IFNA17

Drugs & Compoundsfor IFNA17

Transcriptsfor IFNA17

Expression for IFNA17

Orthologsfor IFNA17

Paralogsfor IFNA17

SNPs/Variantsfor IFNA17

Disorders & Mutationsfor IFNA17

Medical Newsfor IFNA17

Publicationsfor IFNA17

Search for IFNA17

Genome Databases showing IFNA17

Other Databases showing IFNA17

Specialized Databases showing IFNA17

Licensable Technologiesfor IFNA17

Servicesfor IFNA17

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFNA17

Summaries
for IFNA17

Genomic Location
for IFNA17

Proteins
for IFNA17

Protein Domains/
Families
for IFNA17

Gene Function
for IFNA17

Pathways & Interactions
for IFNA17

Drugs & Compounds
for IFNA17

Transcripts
for IFNA17

Expression
for IFNA17

Orthologs
for IFNA17

Paralogs
for IFNA17

SNPs/Variants
for IFNA17

Disorders & Mutations
for IFNA17

Medical News
for IFNA17

Publications
for IFNA17

Licensable Technologies
for IFNA17

Services
for IFNA17