IFNA16 Gene
protein-coding GIFtS: 53
GCID: GC09M021216
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|
interferon, alpha 16
| |
Aliases
for IFNA16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon, Alpha 161 2 | | IFN-AlphaO1 | | Interferon Alpha-WA2 3 | | IFN-Alpha-161 | | IFN-Alpha-N-Protein1 | | Interferon Alpha-162 |
Export aliases for IFNA16 gene to outside databasesPrevious GC identifers: GC09M021543 GC09M021417 GC09M021206 GC09M021179 |
Summaries
for IFNA16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IFN16_HUMAN, P05015Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase
Gene Wiki entry for IFNA16
|
Genomic Views
for IFNA16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFNA16 gene promoter:
Egr-3 Egr-2 C/EBPalpha Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFNA16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22IFNA16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M021216: view genomic region
(about GC identifiers)
Start:
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21,216,372 bp from pter |
End:
|
21,217,310 bp from pter |
Size:
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939 bases |
Orientation:
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minus strand |
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Proteins
for IFNA16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFN16_HUMAN, P05015 (See
protein sequence)Recommended Name: Interferon alpha-16 precursor Size: 189 amino acids; 21711 Da
Subcellular location: Secreted
Secondary accessions: Q5VV12Explore the universe of human proteins at neXtProt for IFNA16: NX_P05015
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P05015
IFNA16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002164.1
ENSEMBL proteins: ENSP00000369564 Reactome Protein details: P05015
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005615 | extracellular space |
IEA | -- |
IFNA16 for ontologies About GeneDecksing
IFNA16 Antibody Products:
Assay Products for IFNA16: |
Protein
Domains /
Families
for IFNA16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFNA16 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P05015ProtoNet protein and cluster: P05015 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFN16_HUMAN, P05015Similarity: Belongs to the alpha/beta interferon family |
Function
for IFNA16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IFN16_HUMAN, P05015Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase Genatlas biochemistry entry for IFNA16:interferon type I,alpha 16,leukocyte
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA16
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNA16 (NM_002173) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA16 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
IFNA16 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for IFNA16:
|
Pathways & Interactions
for IFNA16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of IFNA signaling | | | 2 | Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway | | | 3 | Cytokine Signaling in Immune system | | | 4 | Immune System | | | 5 | Toll-like receptor signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for IFNA16
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA16
2  GeneGo (Thomson Reuters) Pathways for IFNA16
1  BioSystems Pathway for IFNA16
5/11 
Reactome Pathways for IFNA16 (see all 11)
5/12 
Kegg Pathways (Kegg details for IFNA16) (see all 12):
IFNA16 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA16
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/23 Interacting proteins for IFNA16 (P050152, 3 ENSP000003695644) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
IFNA16 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFNA16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFNA16
Search CenterWatch for drugs/clinical trials and news about IFNA16 / IFN16
|
Transcripts
for IFNA16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFNA16 gene: NM_002173.2 Unigene Cluster for IFNA16: Interferon, alpha 16 Hs.56303 Unigene Representative Sequence: M285851 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000380216(uc003zor.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA16
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IFNA16 (NM_002173) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA16 |
Additional cDNA sequence: M28585.1 X00140.1 2 DOTS entries: DT.91651716 DT.121210182 3 AceView cDNA sequences: NM_002173 M28585 X00140
GeneLoc Exon Structure
|
Expression
for IFNA16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFNA16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTACCTTTA
About this image
See IFNA16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA16
SOURCE GeneReport for Unigene cluster: Hs.56303
SABiosciences Expression via Pathway-Focused PCR Arrays including IFNA16 (see all 14): | Antiviral Response in human mouse rat | | Angiogenic Growth Factors in human mouse rat | | Leukemia in human mouse rat | | Interferons & Receptors in human mouse rat | | Toll-Like Receptor Signaling Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IFNA16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA16 |
Orthologs
for IFNA16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFNA16 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for IFNA16 (if available)
TreeFam Gene Tree for IFNA16 (if available) |
Paralogs
for IFNA16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IFNA16 gene
- IFNA72 IFNA22 IFNE2 IFNA42 IFNA142 IFNK2 IFNA52 IFNA12
- IFNA212 IFNA172 IFNA62 IFNB12 IFNA132 IFNW12 IFNA102 IFNA82
18 SIMAP similar genes for IFNA16 using alignment to 1 protein entry: IFN16_HUMAN:IFNA10 IFNA17 IFNA4 IFNA7 IFNA14 IFNA21
IFNA5 IFN-2 IFNA2 IFNA IFNA2B IFNA6
IFNA8 IFNA1 IFNA13 IFNW1 IFNB1 IFNE
IFNA16 for paralogs About GeneDecksing
|
Genomic Variants
for IFNA16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFNA16 (21216372 - 21217310 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IFNA16: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA16 |
|
Disorders
/ Diseases
for IFNA16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFNA16 for disorders About GeneDecksing
OMIM gene information: 147580
OMIM disorders: --
11  diseases for IFNA16: About MalaCardsdengue hemorrhagic fever hemorrhagic fever autoimmune thyroiditis hepatitis c
measles influenza thyroiditis hepatitis
immunodeficiency tuberculosis melanoma
Human Genome Epidemiology (HuGE) Navigator: IFNA16 (2 documents)
Export disorders for IFNA16 gene to outside databases
|
Publications
for IFNA16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFNA16 gene, integrated from 9 sources (see all 55):
(articles sorted by number of sources associating them with IFNA16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
- Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)1, 2 Henco K.... Weissmann C. (1985)
- Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes. (PubMed id 6548765)1, 2 Gren E....Apsalons U. (1984)
- Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene. (PubMed id 6387705)1, 2 Torczynski R.M.... Bollon A.P. (1984)
- Inhibitory effects of human immunodeficiency virus gp1 20 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cel ls. (PubMed id 22814248)1 Fang M....Yao H. (2012)
- HIV-1 Gag-virus-like particles inhibit HIV-1 replicati on in dendritic cells and T cells through IFN-a-dependent upregulation of APOBEC 3G and 3F. (PubMed id 22739040)1 Chang M.O....Takaku H. (2012)
- Role of retroviral restriction factors in the interfer on-a-mediated suppression of HIV-1 in vivo. (PubMed id 22315404)1 Pillai S.K....Wong J.K. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1 Silva L.K....Teixeira M.G. (2010)
- Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843)1 Yang X.R....Goldstein A.M. (2010)
|
External Searches for IFNA16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFNA16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFNA16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNA16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IFNA16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IFNA16 gene:
Search GeneIP for patents involving IFNA16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFNA16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IFNA16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNA16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA16 | | | OriGene Protein Over-expression Lysate for IFNA16 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IFNA16 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IFNA16 | | OriGene Custom Protein Services for IFNA16 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNA16 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA16 |
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| |  |  |  |  | | | | |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA16 |
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