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IFNA16 Gene

protein-coding GIFtS: 51

GC09M021206

interferon, alpha 16
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
IFN-alpha-N-protein ^²
OTTHUMP00000021137 ^²

Descriptions
Interferon alpha-WA ^³
interferon, alpha 16 ^²

External Ids
HGNC: 5421¹
Entrez Gene: 3449²
UniProtKB: P05015³
Ensembl: ENSG00000147885⁷

Search outside databases for aliases for IFNA16 gene

Previous GC identifers: GC09M021543 GC09M021417

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: IFN16_HUMAN, P05015

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the

production of two enzymes: a protein kinase and an oligoadenylate synthetase

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IFNA16 gene

Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22

IFNA16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M021206: (about GC identifiers)

Start:	21,206,372 bp from pter
End:	21,207,310 bp from pter
Size:	939 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFN16_HUMAN, P05015 (See protein sequence)

Recommended Name: Interferon alpha-16 precursor

Size: 189 amino acids; 21711 Da

Subcellular location: Secreted

REFSEQ proteins: NP_002164.1

ENSEMBL proteins:

ENSP00000369564

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IFNA16)
	Human Recombinant Proteins from Abnova (IFNA16)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for IFNA16:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IFNA16), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IFNA16)
	Novus Biologicals Antibodies for IFNA16

Assays for IFNA16:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05015

ProtoNet protein and cluster: P05015

1 Blocks protein family: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFN16_HUMAN, P05015

Similarity: Belongs to the alpha/beta interferon family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFNA16)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002173

Applied Biosystems Silencer® siRNAs for IFNA16

Sigma-Aldrich siRNA for IFNA16

Sigma-Aldrich shRNA Panels and shRNA for IFNA16

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002173
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002173
untagged cDNA clone in CMV expression vector: NM_002173

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002173

UniProtKB/Swiss-Prot: IFN16_HUMAN, P05015

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the

production of two enzymes: a protein kinase and an oligoadenylate synthetase

Genatlas biochemistry entry for IFNA16:

interferon type I,alpha 16,leukocyte

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005132	interferon-alpha/beta receptor binding	TAS	6548765

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for IFNA16 (Your Favorite Gene powered by Ingenuity)

IL-12 Signaling and Production in Macrophages
Role of RIG1-like Receptors in Antiviral Innate Immunity
Role of Cytokines in Mediating Communication between Immune Cells
Activation of IRF by Cytosolic Pattern Recognition Receptors

GeneDecks IFNA16 for the pathways selected above

About GeneDecksing

5/19 Interacting proteins for IFNA16 (ENSP00000369564³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IFNG	ENSP00000229135³	STRING (score=.919)
IFNA17	ENSP00000369562³	STRING (score=.902)
IFNA5	ENSP00000369560³	STRING (score=.902)
IFNA14	ENSP00000369569³	STRING (score=.901)
IFNA8	ENSP00000369553³	STRING (score=.9)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006952	defense response	IEA	--
GO:0009615	response to virus	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFNA16

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IFNA16)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002173

Sigma-Aldrich siRNA for IFNA16

Sigma-Aldrich shRNA Panels and shRNA for IFNA16

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002173

REFSEQ mRNAs for IFNA16 gene:

NM_002173.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002173

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002173
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002173
                                 untagged cDNA clone in CMV expression vector: NM_002173

Additional cDNA sequence:

M28585.1 X00140.1

2 DOTS entries:

DT.91651716 DT.121210182

3 AceView cDNA sequences:

NM_002173 M28585 X00140

highest scoring ESTs for IFNA16:

M28585 X00140 NM_002173

Unigene Cluster for IFNA16:

Interferon, alpha 16

Hs.56303

Unigene Representative Sequence: M28585

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000380216

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IFNA16 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFNA16

¹ / ² / ³

3 probe-sets matching IFNA16 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1075_f_at²^{, 3}	U95-A	15	1.00	0.33	1.00	1.00	M28585	1.00	1.00	1.00	1
208448_x_at²^{, 3}	U133-A	12	1.00	0.41	--	--	NM_002173	0.60	1.00	0.82	1
208448_x_at²	U133Plus2	12	1.00	0.41	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTACCTTTA

SOURCE GeneReport for Unigene cluster: Hs.56303

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for IFNA16 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC741978¹	--	similar to Interferon alpha-16 precursor (Interferon more	97(n) 93.65(a)	741978 XM_001152006.1 XP_001152006.1
cow (Bos taurus)	LOC781732¹	--	similar to interferon alpha G	78.31(n) 62.96(a)	781732 XM_001249939.1 XP_001249940.1
rat (Rattus norvegicus)	Ifna11¹	--	interferon alpha family, gene 11	74.11(n) 60.11(a)	298211 XM_233150.4 XP_233150.2

About this table Species with no ortholog for IFNA16

ENSEMBL Gene Tree for IFNA16

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IFNA16 gene

IFNA1² IFNA21² IFNA2² IFNA7² IFNA17² IFNA6² IFNA4² IFNA14²

IFNA13² IFNA10² IFNA8² IFNA5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/41 NCBI SNPs in IFNA16 are shown (see all 41 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 5)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1834247^1,2	A,C,F,H	21207535(-)	`GTGCAG/CGGGAA`	1	--	ng3¹ trp³		4		EU EA WA	406
--	rs10964912^1,2	A,C,F,H	21208096(+)	`aagctA/Ctttgc`	1	--	ng3¹ tfbs³		5		EU EA WA NS	1708
--	rs1424854^1,2	A,C,F,H	21207849(-)	`ttaacG/Atgtat`	1	--	ng3¹		4		EU EA WA	390
--	rs1820314^1,2	A,C,F,H	21208873(-)	`ACTTGT/AATCCC`	1	--	ng3¹		4		EA NA EU	178
--	rs10125010^1,2	A,C,F,H	21206028(+)	`TTTTAC/TTTGCA`	1	--	ng5¹		4		EU EA WA	416
--	rs10114825^1,2	A,F,H	21208917(+)	`ACTATG/ATTAAC`	1	--	ng3¹		4		EU EA WA	402
--	rs10811512^1,2	A,C	21208648(+)	`ATCAGC/GTATTT`	1	--	ng3¹		0	--	--	--	--
--	rs10811511^1,2	A,C	21208157(+)	`TAAGCA/GATAAC`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs10117927^1,2	A	21208824(+)	`CTGCTA/TAAACC`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs7867026^1,2	H	21208069(+)	`ctgtaC/Gtagaa`	1	--	ng3¹ tfbs³		4		EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for IFNA16 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147580

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/30 PubMed articles for IFNA16 gene (see all 30 ):

Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)^{2, 3} Olopade O.I....Diaz M.O. (1992)
Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)^{3, 4} Henco K.... Weissmann C. (1985)
Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene. (PubMed id 6387705)^{3, 4} Torczynski R.M.... Bollon A.P. (1984)
Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes. (PubMed id 6548765)^{3, 4} Gren E....Apsalons U. (1984)
Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity. (PubMed id 16418394)³ Peng G....Wahl S.M. (2006)
HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration. (PubMed id 16278001)³ Schmidt B....Levy J.A. (2005)
Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells. (PubMed id 16160188)³ Del Corno M....Gessani S. (2005)
Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis. (PubMed id 15481145)³ Conti L....Gessani S. (2004)
HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. (PubMed id 12089333)³ Cicala C....Fauci A.S. (2002)
Effects of IFN alpha on late stages of HIV-1 replication cycle. (PubMed id 9865497)³ Dianzani F....Capobianchi M.R. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3449	HGNC: 5421	AceView: IFNA16	Ensembl:ENSG00000147885	euGenes: HUgn3449
ECgene: IFNA16	H-InvDB: IFNA16

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IFNA16
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IFNA16:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFNA16-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IFNA16		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IFNA16		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for IFNA16

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IFNA16 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for IFNA16

Summaries
for IFNA16

Genomic Location
for IFNA16

Proteins
for IFNA16

Protein Domains/
Families
for IFNA16

Gene Function
for IFNA16

Pathways & Interactions
for IFNA16

Drugs & Compounds
for IFNA16

Transcripts
for IFNA16

Expression
for IFNA16

Orthologs
for IFNA16

Paralogs
for IFNA16

SNPs/Variants
for IFNA16

Disorders & Mutations
for IFNA16

Medical News
for IFNA16

Publications
for IFNA16

Search for IFNA16

Genome Databases showing IFNA16

Other Databases showing IFNA16

Specialized Databases showing IFNA16

Licensable Technologies
for IFNA16

Services
for IFNA16

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFNA16 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor IFNA16

Summariesfor IFNA16

Genomic Locationfor IFNA16

Proteinsfor IFNA16

Protein Domains/Familiesfor IFNA16

Gene Functionfor IFNA16

Pathways & Interactionsfor IFNA16

Drugs & Compoundsfor IFNA16

Transcriptsfor IFNA16

Expression for IFNA16

Orthologsfor IFNA16

Paralogsfor IFNA16

SNPs/Variantsfor IFNA16

Disorders & Mutationsfor IFNA16

Medical Newsfor IFNA16

Publicationsfor IFNA16

Search for IFNA16

Genome Databases showing IFNA16

Other Databases showing IFNA16

Specialized Databases showing IFNA16

Licensable Technologiesfor IFNA16

Servicesfor IFNA16

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFNA16

Summaries
for IFNA16

Genomic Location
for IFNA16

Proteins
for IFNA16

Protein Domains/
Families
for IFNA16

Gene Function
for IFNA16

Pathways & Interactions
for IFNA16

Drugs & Compounds
for IFNA16

Transcripts
for IFNA16

Expression
for IFNA16

Orthologs
for IFNA16

Paralogs
for IFNA16

SNPs/Variants
for IFNA16

Disorders & Mutations
for IFNA16

Medical News
for IFNA16

Publications
for IFNA16

Licensable Technologies
for IFNA16

Services
for IFNA16