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Aliases for IFNA16 Gene

Aliases for IFNA16 Gene

  • Interferon Alpha 16 2 3 5
  • Interferon Alpha-WA 3 4
  • IFN-Alpha-16 3 4
  • Interferon Alpha-16 3
  • IFN-Alpha-N-Protein 3
  • IFN-AlphaO 3

External Ids for IFNA16 Gene

Previous GeneCards Identifiers for IFNA16 Gene

  • GC09M021543
  • GC09M021417
  • GC09M021206
  • GC09M021179

Summaries for IFNA16 Gene

GeneCards Summary for IFNA16 Gene

IFNA16 (Interferon Alpha 16) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA4.

UniProtKB/Swiss-Prot for IFNA16 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA16 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA16 Gene

Genomics for IFNA16 Gene

Regulatory Elements for IFNA16 Gene

Enhancers for IFNA16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F021213 0.6 Ensembl 0.8 +3.2 3238 0.7 CTCF RAD21 IFNA13 IFNA20P IFNA16 IFNWP18
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IFNA16 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNA16 Gene

Chromosome:
9
Start:
21,216,373 bp from pter
End:
21,217,311 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for IFNA16 Gene

Genes around IFNA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA16 Gene

Proteins for IFNA16 Gene

  • Protein details for IFNA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05015-IFN16_HUMAN
    Recommended name:
    Interferon alpha-16
    Protein Accession:
    P05015
    Secondary Accessions:
    • Q5VV12

    Protein attributes for IFNA16 Gene

    Size:
    189 amino acids
    Molecular mass:
    21711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA16 Gene

Post-translational modifications for IFNA16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IFNA16

No data available for DME Specific Peptides for IFNA16 Gene

Domains & Families for IFNA16 Gene

Gene Families for IFNA16 Gene

Suggested Antigen Peptide Sequences for IFNA16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05015

UniProtKB/Swiss-Prot:

IFN16_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA16: view

Function for IFNA16 Gene

Molecular function for IFNA16 Gene

GENATLAS Biochemistry:
interferon type I,alpha 16,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS 6548765
genes like me logo Genes that share ontologies with IFNA16: view
genes like me logo Genes that share phenotypes with IFNA16: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA16 Gene

Localization for IFNA16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA16 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA16 Gene COMPARTMENTS Subcellular localization image for IFNA16 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA16: view

Pathways & Interactions for IFNA16 Gene

genes like me logo Genes that share pathways with IFNA16: view

Gene Ontology (GO) - Biological Process for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA16: view

No data available for SIGNOR curated interactions for IFNA16 Gene

Transcripts for IFNA16 Gene

mRNA/cDNA for IFNA16 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA16 Gene

No ASD Table

Relevant External Links for IFNA16 Gene

GeneLoc Exon Structure for
IFNA16
ECgene alternative splicing isoforms for
IFNA16

Expression for IFNA16 Gene

mRNA expression in normal human tissues for IFNA16 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNA16 Gene:

IFNA16

SOURCE GeneReport for Unigene cluster for IFNA16 Gene:

Hs.56303
genes like me logo Genes that share expression patterns with IFNA16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IFNA16 Gene

Orthologs for IFNA16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA16 34
  • 97 (n)
-- 35
  • 75 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia LOC538620 34
  • 78.66 (n)
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
IFNAG 35 35
  • 62 (a)
ManyToMany
IFNAH 35
  • 62 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
IFNAA 35
  • 61 (a)
ManyToMany
INFAF 35
  • 61 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia IFNA7 34
  • 70.05 (n)
mouse
(Mus musculus)
Mammalia Gm12597 35
  • 61 (a)
ManyToMany
Ifna13 35
  • 61 (a)
ManyToMany
Ifna5 35
  • 61 (a)
ManyToMany
Ifna6 35
  • 61 (a)
ManyToMany
Ifna1 35
  • 60 (a)
ManyToMany
Ifna12 35
  • 60 (a)
ManyToMany
Gm13280 35
  • 59 (a)
ManyToMany
Ifna14 35
  • 59 (a)
ManyToMany
Ifnab 35
  • 59 (a)
ManyToMany
Ifna2 35
  • 58 (a)
ManyToMany
Ifna9 35
  • 58 (a)
ManyToMany
Ifna11 35
  • 57 (a)
ManyToMany
Ifna7 35
  • 57 (a)
ManyToMany
Ifna4 35
  • 56 (a)
ManyToMany
Species where no ortholog for IFNA16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA16 Gene

ENSEMBL:
Gene Tree for IFNA16 (if available)
TreeFam:
Gene Tree for IFNA16 (if available)

Paralogs for IFNA16 Gene

(18) SIMAP similar genes for IFNA16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA16: view

Variants for IFNA16 Gene

Sequence variations from dbSNP and Humsavar for IFNA16 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10114825 -- 21,218,918(+) ACTAT(A/G)TTAAC upstream-variant-2KB
rs10117927 -- 21,218,825(+) CTGCT(A/T)AAACC upstream-variant-2KB
rs10125010 -- 21,216,029(+) TTTTA(C/T)TTGCA downstream-variant-500B
rs10811511 -- 21,218,158(+) TAAGC(A/G)ATAAC upstream-variant-2KB
rs10811512 -- 21,218,649(+) ATCAG(C/G)TATTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNA16 Gene

Variant ID Type Subtype PubMed ID
dgv7474n100 CNV loss 25217958
esv2738274 CNV deletion 23290073
esv2738277 CNV deletion 23290073
esv2738279 CNV deletion 23290073
esv2764150 CNV gain+loss 21179565
esv3573167 CNV loss 25503493
esv3619955 CNV loss 21293372
nsv1021574 CNV gain 25217958
nsv1035128 CNV gain 25217958
nsv613756 CNV loss 21841781
nsv968599 CNV duplication 23825009

Variation tolerance for IFNA16 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA16 Gene

Disorders for IFNA16 Gene

Relevant External Links for IFNA16

Genetic Association Database (GAD)
IFNA16
Human Genome Epidemiology (HuGE) Navigator
IFNA16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA16

No disorders were found for IFNA16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA16 Gene

Publications for IFNA16 Gene

  1. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 46 64
  2. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 64
  3. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3 64
  4. Structural relationship of human interferon alpha genes and pseudogenes. (PMID: 4057246) Henco K. … Weissmann C. (J. Mol. Biol. 1985) 3 4 64
  5. Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene. (PMID: 6387705) Torczynski R.M. … Bollon A.P. (Proc. Natl. Acad. Sci. U.S.A. 1984) 3 4 64

Products for IFNA16 Gene

Sources for IFNA16 Gene

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