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Aliases for IFNA16 Gene

Aliases for IFNA16 Gene

  • Interferon, Alpha 16 2 3 5
  • Interferon Alpha-WA 3 4
  • IFN-Alpha-16 3 4
  • IFN-Alpha-N-Protein 3
  • IFN-AlphaO 3

External Ids for IFNA16 Gene

Previous GeneCards Identifiers for IFNA16 Gene

  • GC09M021543
  • GC09M021417
  • GC09M021206
  • GC09M021179

Summaries for IFNA16 Gene

GeneCards Summary for IFNA16 Gene

IFNA16 (Interferon, Alpha 16) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA16 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA16 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA16 Gene

Genomics for IFNA16 Gene

Regulatory Elements for IFNA16 Gene

Genomic Location for IFNA16 Gene

21,216,373 bp from pter
21,217,311 bp from pter
939 bases
Minus strand

Genomic View for IFNA16 Gene

Genes around IFNA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA16 Gene

Proteins for IFNA16 Gene

  • Protein details for IFNA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-16
    Protein Accession:
    Secondary Accessions:
    • Q5VV12

    Protein attributes for IFNA16 Gene

    189 amino acids
    Molecular mass:
    21711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA16 Gene

Proteomics data for IFNA16 Gene at MOPED

Post-translational modifications for IFNA16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IFNA16 Gene

Domains & Families for IFNA16 Gene

Gene Families for IFNA16 Gene

Suggested Antigen Peptide Sequences for IFNA16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA16: view

Function for IFNA16 Gene

Molecular function for IFNA16 Gene

GENATLAS Biochemistry:
interferon type I,alpha 16,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
genes like me logo Genes that share phenotypes with IFNA16: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA16 Gene

Localization for IFNA16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA16 Gene


Subcellular locations from

Jensen Localization Image for IFNA16 Gene COMPARTMENTS Subcellular localization image for IFNA16 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for IFNA16 Gene

Pathways & Interactions for IFNA16 Gene

genes like me logo Genes that share pathways with IFNA16: view

Gene Ontology (GO) - Biological Process for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
GO:0007596 blood coagulation TAS --
GO:0019221 cytokine-mediated signaling pathway IBA,TAS --
genes like me logo Genes that share ontologies with IFNA16: view

No data available for SIGNOR curated interactions for IFNA16 Gene

Drugs & Compounds for IFNA16 Gene

No Compound Related Data Available

Transcripts for IFNA16 Gene

mRNA/cDNA for IFNA16 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA16 Gene

No ASD Table

Relevant External Links for IFNA16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA16 Gene

mRNA expression in normal human tissues for IFNA16 Gene

SOURCE GeneReport for Unigene cluster for IFNA16 Gene Hs.56303

genes like me logo Genes that share expression patterns with IFNA16: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFNA16 Gene

Orthologs for IFNA16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC538620 35
  • 78.66 (n)
  • 62.77 (a)
-- 36
  • 62 (a)
-- 36
  • 62 (a)
-- 36
  • 62 (a)
-- 36
  • 62 (a)
-- 36
  • 61 (a)
  • 61 (a)
  • 62 (a)
  • 63 (a)
  • 62 (a)
  • 61 (a)
(Canis familiaris)
Mammalia IFNA7 35
  • 70.05 (n)
  • 54.01 (a)
(Pan troglodytes)
Mammalia IFNA16 35
  • 97 (n)
  • 93.65 (a)
-- 36
  • 75 (a)
(Mus musculus)
Mammalia Gm12597 36
  • 61 (a)
Gm13280 36
  • 59 (a)
Ifna1 36
  • 60 (a)
Ifna11 36
  • 57 (a)
Ifna12 36
  • 60 (a)
Ifna13 36
  • 61 (a)
Ifna14 36
  • 59 (a)
Ifna2 36
  • 58 (a)
Ifna4 36
  • 56 (a)
Ifna5 36
  • 61 (a)
Ifna6 36
  • 61 (a)
Ifna7 36
  • 57 (a)
Ifna9 36
  • 58 (a)
Ifnab 36
  • 59 (a)
Species with no ortholog for IFNA16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA16 Gene

Gene Tree for IFNA16 (if available)
Gene Tree for IFNA16 (if available)

Paralogs for IFNA16 Gene

(18) SIMAP similar genes for IFNA16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA16: view

Variants for IFNA16 Gene

Sequence variations from dbSNP and Humsavar for IFNA16 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1820314 -- 21,218,874(-) ACTTG(A/T)ATCCC upstream-variant-2KB
rs1834247 -- 21,217,536(-) GTGCA(C/G)GGGAA upstream-variant-2KB
rs1424854 -- 21,217,850(-) TTAAC(A/G)TGTAT upstream-variant-2KB
rs1946315 -- 21,216,585(-) CGTGT(A/T)TACCT utr-variant-3-prime
rs1946316 -- 21,216,335(-) TAAAT(A/G)CCAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IFNA16 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294
esv2738274 CNV Deletion 23290073
esv2738277 CNV Deletion 23290073
esv2738279 CNV Deletion 23290073

Variation tolerance for IFNA16 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA16 Gene

Disorders for IFNA16 Gene

Relevant External Links for IFNA16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IFNA16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA16 Gene

Publications for IFNA16 Gene

  1. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 48 67
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  3. HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms. (PMID: 25972534) Reszka-Blanco N.J. … Su L. (J. Virol. 2015) 3
  4. Evidence for a different susceptibility of primate lentiviruses to type I interferons. (PMID: 23255800) Cordeil S. … Cimarelli A. (J. Virol. 2013) 3
  5. Role of retroviral restriction factors in the interferon-I+-mediated suppression of HIV-1 in vivo. (PMID: 22315404) Pillai S.K. … Wong J.K. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3

Products for IFNA16 Gene

Sources for IFNA16 Gene

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