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Aliases for IFNA16 Gene

Aliases for IFNA16 Gene

  • Interferon, Alpha 16 2 3
  • Interferon Alpha-WA 3 4
  • IFN-Alpha-16 3 4
  • Interferon Alpha-16 3
  • IFN-Alpha-N-Protein 3
  • IFN-AlphaO 3

External Ids for IFNA16 Gene

Previous GeneCards Identifiers for IFNA16 Gene

  • GC09M021543
  • GC09M021417
  • GC09M021206
  • GC09M021179

Summaries for IFNA16 Gene

GeneCards Summary for IFNA16 Gene

IFNA16 (Interferon, Alpha 16) is a Protein Coding gene. Diseases associated with IFNA16 include dengue hemorrhagic fever and hiv-1. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA16 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA16 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA16 Gene

Genomics for IFNA16 Gene

Regulatory Elements for IFNA16 Gene

Genomic Location for IFNA16 Gene

Start:
21,216,373 bp from pter
End:
21,239,935 bp from pter
Size:
23,563 bases
Orientation:
Minus strand

Genomic View for IFNA16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA16 Gene

Proteins for IFNA16 Gene

  • Protein details for IFNA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05015-IFN16_HUMAN
    Recommended name:
    Interferon alpha-16
    Protein Accession:
    P05015
    Secondary Accessions:
    • Q5VV12

    Protein attributes for IFNA16 Gene

    Size:
    189 amino acids
    Molecular mass:
    21711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA16 Gene

Proteomics data for IFNA16 Gene at MOPED

Post-translational modifications for IFNA16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA16 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA16 Gene

Domains for IFNA16 Gene

Gene Families for IFNA16 Gene

HGNC:
  • IFN :Interferons

Suggested Antigen Peptide Sequences for IFNA16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05015

UniProtKB/Swiss-Prot:

IFN16_HUMAN :
  • P05015
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA16: view

Function for IFNA16 Gene

Molecular function for IFNA16 Gene

GENATLAS Biochemistry: interferon type I,alpha 16,leukocyte
UniProtKB/Swiss-Prot Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Ontology (GO) - Molecular Function for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA16: view

Phenotypes for IFNA16 Gene

GenomeRNAi human phenotypes for IFNA16:
genes like me logo Genes that share phenotypes with IFNA16: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNA16 Gene

Localization for IFNA16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA16 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA16 Gene COMPARTMENTS Subcellular localization image for IFNA16 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA16: view

Pathways for IFNA16 Gene

genes like me logo Genes that share pathways with IFNA16: view

Gene Ontology (GO) - Biological Process for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA16: view

Transcripts for IFNA16 Gene

mRNA/cDNA for IFNA16 Gene

(3) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA16 Gene

No ASD Table

Relevant External Links for IFNA16 Gene

GeneLoc Exon Structure for
IFNA16
ECgene alternative splicing isoforms for
IFNA16

Expression for IFNA16 Gene

mRNA expression in normal human tissues for IFNA16 Gene

SOURCE GeneReport for Unigene cluster for IFNA16 Gene Hs.56303

genes like me logo Genes that share expressions with IFNA16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for IFNA16 Gene

Orthologs for IFNA16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 75 (a)
ManyToMany
IFNA16 35
  • 97 (n)
  • 93.65 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
IFNAA 36
  • 61 (a)
ManyToMany
IFNAG 36
  • 62 (a)
ManyToMany
IFNAG 36
  • 63 (a)
ManyToMany
IFNAH 36
  • 62 (a)
ManyToMany
INFAF 36
  • 61 (a)
ManyToMany
LOC538620 35
  • 78.66 (n)
  • 62.77 (a)
dog
(Canis familiaris)
Mammalia IFNA7 35
  • 70.05 (n)
  • 54.01 (a)
mouse
(Mus musculus)
Mammalia Gm12597 36
  • 61 (a)
ManyToMany
Gm13280 36
  • 59 (a)
ManyToMany
Ifna1 36
  • 60 (a)
ManyToMany
Ifna11 36
  • 57 (a)
ManyToMany
Ifna12 36
  • 60 (a)
ManyToMany
Ifna13 36
  • 61 (a)
ManyToMany
Ifna14 36
  • 59 (a)
ManyToMany
Ifna2 36
  • 58 (a)
ManyToMany
Ifna4 16
Ifna4 36
  • 56 (a)
ManyToMany
Ifna5 36
  • 61 (a)
ManyToMany
Ifna6 36
  • 61 (a)
ManyToMany
Ifna7 36
  • 57 (a)
ManyToMany
Ifna9 36
  • 58 (a)
ManyToMany
Ifnab 36
  • 59 (a)
ManyToMany
Species with no ortholog for IFNA16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA16 Gene

ENSEMBL:
Gene Tree for IFNA16 (if available)
TreeFam:
Gene Tree for IFNA16 (if available)

Paralogs for IFNA16 Gene

Selected SIMAP similar genes for IFNA16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA16: view

Variants for IFNA16 Gene

Sequence variations from dbSNP and Humsavar for IFNA16 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1424854 -- 21,217,850(-) TTAAC(A/G)TGTAT upstream-variant-2KB
rs1820314 -- 21,218,874(-) ACTTG(A/T)ATCCC upstream-variant-2KB
rs1834247 -- 21,217,536(-) GTGCA(C/G)GGGAA upstream-variant-2KB
rs1946315 -- 21,216,585(-) CGTGT(A/T)TACCT utr-variant-3-prime
rs1946316 -- 21,216,335(-) TAAAT(A/G)CCAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IFNA16 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294
esv2738274 CNV Deletion 23290073
esv2738277 CNV Deletion 23290073
esv2738279 CNV Deletion 23290073

Relevant External Links for IFNA16 Gene

HapMap Linkage Disequilibrium report
IFNA16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA16 Gene

Disorders for IFNA16 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for IFNA16 Gene including...

Search for IFNA16 Gene in MalaCards »

Relevant External Links for IFNA16

Genetic Association Database (GAD)
IFNA16
Human Genome Epidemiology (HuGE) Navigator
IFNA16
genes like me logo Genes that share disorders with IFNA16: view

No data available for UniProtKB/Swiss-Prot for IFNA16 Gene

Publications for IFNA16 Gene

  1. Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes. (PMID: 6548765) Gren E. … Apsalons U. (J. Interferon Res. 1984) 3 4
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  3. Structural relationship of human interferon alpha genes and pseudogenes. (PMID: 4057246) Henco K. … Weissmann C. (J. Mol. Biol. 1985) 3 4
  4. Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene. (PMID: 6387705) Torczynski R.M. … Bollon A.P. (Proc. Natl. Acad. Sci. U.S.A. 1984) 3 4
  5. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 48

Products for IFNA16 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenesis in human,mouse,rat
    • Angiogenic Growth Factors in human,mouse,rat
    • Antiviral Response in human,mouse,rat
    • Apoptosis 384HT in human,mouse,rat
    • Common Cytokines in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNA16
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA16
    • Block miRNA regulation of IFNA16 using miScript Target Protectors

    Sources for IFNA16 Gene

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