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Aliases for IFNA16 Gene

Aliases for IFNA16 Gene

  • Interferon Alpha 16 2 3 5
  • Interferon Alpha-WA 3 4
  • IFN-Alpha-16 3 4
  • Interferon Alpha-16 3
  • IFN-Alpha-N-Protein 3
  • IFN-AlphaO 3

External Ids for IFNA16 Gene

Previous GeneCards Identifiers for IFNA16 Gene

  • GC09M021543
  • GC09M021417
  • GC09M021206
  • GC09M021179

Summaries for IFNA16 Gene

GeneCards Summary for IFNA16 Gene

IFNA16 (Interferon Alpha 16) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA4.

UniProtKB/Swiss-Prot for IFNA16 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA16 Gene

Additional gene information for IFNA16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA16 Gene

Genomics for IFNA16 Gene

GeneHancer (GH) Regulatory Elements for IFNA16 Gene

Promoters and enhancers for IFNA16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I021217 Promoter 0.5 EPDnew 550.8 -0.1 -82 0.1 IFNA16 IFNA13 GC09P021226
GH09I021214 Enhancer 0.4 Ensembl 0.8 +3.2 3210 0.2 CTCF RAD21 IFNA13 IFNA20P IFNA16 IFNWP18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFNA16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNA16 gene promoter:

Genomic Locations for IFNA16 Gene

Genomic Locations for IFNA16 Gene
939 bases
Minus strand

Genomic View for IFNA16 Gene

Genes around IFNA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA16 Gene

Proteins for IFNA16 Gene

  • Protein details for IFNA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-16
    Protein Accession:
    Secondary Accessions:
    • Q5VV12

    Protein attributes for IFNA16 Gene

    189 amino acids
    Molecular mass:
    21711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA16 Gene

Post-translational modifications for IFNA16 Gene

No Post-translational modifications

Other Protein References for IFNA16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA16 Gene

Domains & Families for IFNA16 Gene

Gene Families for IFNA16 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IFNA16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA16: view

Function for IFNA16 Gene

Molecular function for IFNA16 Gene

GENATLAS Biochemistry:
interferon type I,alpha 16,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS 6548765
genes like me logo Genes that share ontologies with IFNA16: view
genes like me logo Genes that share phenotypes with IFNA16: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA16 Gene

Localization for IFNA16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA16 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA16 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA16 Gene

Pathways & Interactions for IFNA16 Gene

genes like me logo Genes that share pathways with IFNA16: view

Gene Ontology (GO) - Biological Process for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA16: view

No data available for SIGNOR curated interactions for IFNA16 Gene

Drugs & Compounds for IFNA16 Gene

No Compound Related Data Available

Transcripts for IFNA16 Gene

mRNA/cDNA for IFNA16 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA16 Gene

No ASD Table

Relevant External Links for IFNA16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNA16 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNA16 Gene:


SOURCE GeneReport for Unigene cluster for IFNA16 Gene:

genes like me logo Genes that share expression patterns with IFNA16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA16 Gene

Orthologs for IFNA16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNA16 33
  • 97 (n)
-- 34
  • 75 (a)
(Bos Taurus)
Mammalia LOC538620 33
  • 78.66 (n)
-- 34
  • 62 (a)
-- 34
  • 62 (a)
-- 34
  • 62 (a)
-- 34
  • 62 (a)
IFNAG 34 34
  • 62 (a)
  • 62 (a)
-- 34
  • 61 (a)
  • 61 (a)
  • 61 (a)
(Canis familiaris)
Mammalia IFNA7 33
  • 70.05 (n)
(Mus musculus)
Mammalia Gm12597 34
  • 61 (a)
Ifna13 34
  • 61 (a)
Ifna5 34
  • 61 (a)
Ifna6 34
  • 61 (a)
Ifna1 34
  • 60 (a)
Ifna12 34
  • 60 (a)
Gm13280 34
  • 59 (a)
Ifna14 34
  • 59 (a)
Ifnab 34
  • 59 (a)
Ifna2 34
  • 58 (a)
Ifna9 34
  • 58 (a)
Ifna11 34
  • 57 (a)
Ifna7 34
  • 57 (a)
Ifna4 34
  • 56 (a)
Species where no ortholog for IFNA16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA16 Gene

Gene Tree for IFNA16 (if available)
Gene Tree for IFNA16 (if available)

Paralogs for IFNA16 Gene

(18) SIMAP similar genes for IFNA16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA16: view

Variants for IFNA16 Gene

Sequence variations from dbSNP and Humsavar for IFNA16 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000022050 -- 21,218,532(-) T/C upstream_transcript_variant
rs1000302961 -- 21,218,352(-) G/C upstream_transcript_variant
rs1000638480 -- 21,217,642(-) T/G upstream_transcript_variant
rs1002218812 -- 21,218,627(-) G/A upstream_transcript_variant
rs1002640015 -- 21,216,185(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNA16 Gene

Variant ID Type Subtype PubMed ID
dgv7474n100 CNV loss 25217958
esv2738274 CNV deletion 23290073
esv2738277 CNV deletion 23290073
esv2738279 CNV deletion 23290073
esv2764150 CNV gain+loss 21179565
esv3573167 CNV loss 25503493
esv3619955 CNV loss 21293372
nsv1021574 CNV gain 25217958
nsv1035128 CNV gain 25217958
nsv613756 CNV loss 21841781
nsv968599 CNV duplication 23825009

Variation tolerance for IFNA16 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA16 Gene

Disorders for IFNA16 Gene

Additional Disease Information for IFNA16

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IFNA16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA16 Gene

Publications for IFNA16 Gene

  1. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 44 58
  3. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade OI … Diaz MO (Genomics 1992) 2 3 58
  4. Structural relationship of human interferon alpha genes and pseudogenes. (PMID: 4057246) Henco K … Schmid J (Journal of molecular biology 1985) 3 4 58
  5. Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene. (PMID: 6387705) Torczynski RM … Bollon AP (Proceedings of the National Academy of Sciences of the United States of America 1984) 3 4 58

Products for IFNA16 Gene

Sources for IFNA16 Gene

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