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IFNA14 Gene

protein-coding GIFtS: 54

GC09M021211

interferon, alpha 14
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
LEIF2H ^¹, ²
MGC125756 ^²
MGC125757 ^²
OTTHUMP00000021139 ^²

Descriptions
Interferon alpha-H ^³
Interferon lambda-2-H ^³
LeIF H ^³
interferon, alpha 14 ^²

External Ids
HGNC: 5420¹
Entrez Gene: 3448²
UniProtKB: P01570³
Ensembl: ENSG00000186809⁷

Search outside databases for aliases for IFNA14 gene

Previous GC identifers: GC09M021566 GC09M021403 GC09M021192 GC09M021229 GC09M021193 GC09M021194 GC09M021208

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: IFN14_HUMAN, P01570

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the

production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IFNA14 gene

Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22

IFNA14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M021211: (about GC identifiers)

Start:	21,191,234 bp from pter
End:	21,229,990 bp from pter
Size:	38,757 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFN14_HUMAN, P01570 (See protein sequence)

Recommended Name: Interferon alpha-14 precursor

Size: 189 amino acids; 22063 Da

Subcellular location: Secreted

Secondary accessions: Q5VZ56 Q7M4S1

REFSEQ proteins: NP_002163.2

ENSEMBL proteins:

ENSP00000259555 ENSP00000369569

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IFNA14 (IFN-alpha H2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IFNA14)
	Human Recombinant Proteins from Abnova (IFNA14)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for IFNA14:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IFNA14), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IFNA14)
	Novus Biologicals Antibodies for IFNA14

Assays for IFNA14:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01570

ProtoNet protein and cluster: P01570

1 Blocks protein family: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFN14_HUMAN, P01570

Similarity: Belongs to the alpha/beta interferon family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002172

Applied Biosystems Silencer® siRNAs for IFNA14

Sigma-Aldrich siRNA for IFNA14

Sigma-Aldrich shRNA Panels and shRNA for IFNA14

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IFNA14
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002172
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002172
untagged cDNA clone in CMV expression vector: NM_002172

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002172

UniProtKB/Swiss-Prot: IFN14_HUMAN, P01570

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the

production of two enzymes: a protein kinase and an oligoadenylate synthetase

Genatlas biochemistry entry for IFNA14:

interferon type I,alpha 14,leukocyte

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005126	hematopoietin/interferon-class (D200-domain) cytokine receptor binding	TAS	6163083

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for IFNA14 (Your Favorite Gene powered by Ingenuity)

IL-12 Signaling and Production in Macrophages
Role of Cytokines in Mediating Communication between Immune Cells
Role of RIG1-like Receptors in Antiviral Innate Immunity
Activation of IRF by Cytosolic Pattern Recognition Receptors

GeneDecks IFNA14 for the pathways selected above

About GeneDecksing

5/22 Interacting proteins for IFNA14 (ENSP00000369569³) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IFNAR2	ENSP00000371676³	STRING (score=.964)
IFNG	ENSP00000229135³	STRING (score=.96)
IRF7	ENSP00000329411³	STRING (score=.93)
IFNA17	ENSP00000369562³	STRING (score=.902)
IFNA16	ENSP00000369564³	STRING (score=.901)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006952	defense response	IEA	--
GO:0009615	response to virus	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IFNA14

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002172

Sigma-Aldrich siRNA for IFNA14

Sigma-Aldrich shRNA Panels and shRNA for IFNA14

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002172

REFSEQ mRNAs for IFNA14 gene:

NM_002172.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002172

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002172
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002172
                                 untagged cDNA clone in CMV expression vector: NM_002172

Additional cDNA sequence:

BC074956.2 BC104159.1 BC104160.1 V00542.1

1 DOTS entry:

DT.91651716

6 AceView cDNA sequences:

BC074956 NM_002172 V00542 CR541921 BC069471 NM_021002

highest scoring ESTs for IFNA14:

V00542 BC104159 BC104160 BC074956 NM_002172 J00214

Unigene Cluster for IFNA14:

Interferon, alpha 14

Hs.93907

Unigene Representative Sequence: V00542

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000259555 ENST00000380220

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IFNA14 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IFNA14

¹ / ² / ³

4 probe-sets matching IFNA14 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1022_f_at²^{, 3}	U95-A	14	1.00	0.48	1.00	1.00	V00542	1.00	0.73	0.87	1
1075_f_at²	U95-A	15	0.81	0.20	0.63	0.90	--	--	--	--	--
208182_x_at²^{, 3}	U133-A	14	1.00	0.35	--	--	NM_002172	0.60	0.83	0.73	1
208182_x_at²	U133Plus2	14	1.00	0.35	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.93907

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IFNA14 gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IFNA7¹	--	interferon, alpha 7	71.12(n) 56.68(a)	474181 NM_001006654.1 NP_001006655.1
chimpanzee (Pan troglodytes)	LOC473193¹	--	hypothetical LOC473193	98.59(n) 97.88(a)	473193 XM_528563.2 XP_528563.2

About this table Species with no ortholog for IFNA14

ENSEMBL Gene Tree for IFNA14

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IFNA14 gene

IFNA1² IFNA21² IFNA2² IFNA7² IFNA17² IFNA6² IFNA4² IFNA13²

IFNA16² IFNA10² IFNA8² IFNA5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/18 NCBI SNPs in IFNA14 are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 17)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs4628333^1,2	A,C,F,H	21228962(+)	`TTGACG/ATTTTA`	1	--	ng5¹		7		EU EA WA NA	556
	rs10964932^1,2	A,C,F,H	21231856(+)	`CCAAGT/ATGGAG`	1	--	ng3¹		4		EU EA WA	416
	rs12553763^1,2	A,C,F,H	21231449(+)	`CTGAAG/TGAGTA`	1	--	ng3¹		4		EU EA WA	416
	rs12551190^1,2	C,F,H	21231489(+)	`ATTAAA/GCAAAT`	1	--	ng3¹		4		EU EA WA	414
	rs7868193^1,2	F,H	21229995(+)	`GGTTGT/CAGGTT`	1	--	ng3¹		4		EU EA WA	418
--	rs17334054^1,2	F	21231600(-)	`ACATCC/TCATTA`	1	--	ng3¹		1		NS	1412
	rs10964931^1,2	H	21231651(+)	`GCAGGA/GCACCA`	1	--	ng3¹		4		EU EA WA	416
--	rs28383770^1,2	--	21229552(-)	`GGTTGA/GGGTGG`	1	G/E	mis¹		0	--	--	--	--
--	rs59402770^1,2	--	21230427(+)	`GACTTA/GCCAAC`	1	--	ng3¹		0	--	--	--	--
	rs28383769^1,2	--	21230066(-)	`GAAGAC/TGTTCA`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for IFNA14 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147579

Human Genome Epidemiology Navigator: IFNA14 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/16 PubMed articles for IFNA14 gene (see all 16 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)^{3, 4} Nyman T.A.... Kalkkinen N. (1998)
Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (PubMed id 8910771)^{3, 4} Hussain M.... Liao M.-J. (1996)
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)^{2, 3} Olopade O.I....Diaz M.O. (1992)
Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)^{3, 4} Henco K.... Weissmann C. (1985)
DNA sequence of two closely linked human leukocyte interferon genes. (PubMed id 6165082)^{3, 4} Lawn R.M.... Ullrich A. (1981)
The structure of eight distinct cloned human leukocyte interferon cDNAs. (PubMed id 6163083)^{3, 4} Goeddel D.V.... Gray P.W. (1981)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)³ Siezen C.L....Janssen R. (2009)
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)³ Janssen R....Hoebee B. (2007)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)⁴ Humphray S.J.... Dunham I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3448	HGNC: 5420	AceView: IFNA14	Ensembl:ENSG00000186809	euGenes: HUgn3448
ECgene: IFNA14	H-InvDB: IFNA14

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IFNA14
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IFNA14:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IFNA14-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IFNA14		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IFNA14		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for IFNA14

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IFNA14 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for IFNA14

Summaries
for IFNA14

Genomic Location
for IFNA14

Proteins
for IFNA14

Protein Domains/
Families
for IFNA14

Gene Function
for IFNA14

Pathways & Interactions
for IFNA14

Drugs & Compounds
for IFNA14

Transcripts
for IFNA14

Expression
for IFNA14

Orthologs
for IFNA14

Paralogs
for IFNA14

SNPs/Variants
for IFNA14

Disorders & Mutations
for IFNA14

Medical News
for IFNA14

Publications
for IFNA14

Search for IFNA14

Genome Databases showing IFNA14

Other Databases showing IFNA14

Specialized Databases showing IFNA14

Licensable Technologies
for IFNA14

Services
for IFNA14

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IFNA14 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor IFNA14

Summariesfor IFNA14

Genomic Locationfor IFNA14

Proteinsfor IFNA14

Protein Domains/Familiesfor IFNA14

Gene Functionfor IFNA14

Pathways & Interactionsfor IFNA14

Drugs & Compoundsfor IFNA14

Transcriptsfor IFNA14

Expression for IFNA14

Orthologsfor IFNA14

Paralogsfor IFNA14

SNPs/Variantsfor IFNA14

Disorders & Mutationsfor IFNA14

Medical Newsfor IFNA14

Publicationsfor IFNA14

Search for IFNA14

Genome Databases showing IFNA14

Other Databases showing IFNA14

Specialized Databases showing IFNA14

Licensable Technologiesfor IFNA14

Servicesfor IFNA14

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IFNA14

Summaries
for IFNA14

Genomic Location
for IFNA14

Proteins
for IFNA14

Protein Domains/
Families
for IFNA14

Gene Function
for IFNA14

Pathways & Interactions
for IFNA14

Drugs & Compounds
for IFNA14

Transcripts
for IFNA14

Expression
for IFNA14

Orthologs
for IFNA14

Paralogs
for IFNA14

SNPs/Variants
for IFNA14

Disorders & Mutations
for IFNA14

Medical News
for IFNA14

Publications
for IFNA14

Licensable Technologies
for IFNA14

Services
for IFNA14