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Aliases for IFNA14 Gene

Aliases for IFNA14 Gene

  • Interferon, Alpha 14 2 3
  • Interferon Lambda-2-H 3 4
  • Interferon Alpha-H 3 4
  • IFN-Alpha-14 3 4
  • LeIF H 3 4
  • Interferon Alpha-14 3
  • IFN-AlphaH 3
  • LEIF2H 3

External Ids for IFNA14 Gene

Previous GeneCards Identifiers for IFNA14 Gene

  • GC09M021566
  • GC09M021403
  • GC09M021192
  • GC09M021229
  • GC09M021193
  • GC09M021194
  • GC09M021208
  • GC09M021211

Summaries for IFNA14 Gene

GeneCards Summary for IFNA14 Gene

IFNA14 (Interferon, Alpha 14) is a Protein Coding gene. Diseases associated with IFNA14 include hiv-1. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and cytokine receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA14 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA14 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA14 Gene

Genomics for IFNA14 Gene

Regulatory Elements for IFNA14 Gene

Genomic Location for IFNA14 Gene

Start:
21,239,002 bp from pter
End:
21,239,991 bp from pter
Size:
990 bases
Orientation:
Minus strand

Genomic View for IFNA14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA14 Gene

Proteins for IFNA14 Gene

  • Protein details for IFNA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01570-IFN14_HUMAN
    Recommended name:
    Interferon alpha-14
    Protein Accession:
    P01570
    Secondary Accessions:
    • Q5VZ56
    • Q7M4S1

    Protein attributes for IFNA14 Gene

    Size:
    189 amino acids
    Molecular mass:
    22063 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA14 Gene

Proteomics data for IFNA14 Gene at MOPED

Post-translational modifications for IFNA14 Gene

Other Protein References for IFNA14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA14 Gene

Domains for IFNA14 Gene

Gene Families for IFNA14 Gene

HGNC:
  • IFN :Interferons

Suggested Antigen Peptide Sequences for IFNA14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01570

UniProtKB/Swiss-Prot:

IFN14_HUMAN :
  • P01570
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA14: view

Function for IFNA14 Gene

Molecular function for IFNA14 Gene

GENATLAS Biochemistry: interferon type I,alpha 14,leukocyte
UniProtKB/Swiss-Prot Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA14: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNA14 Gene

Localization for IFNA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA14 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA14 Gene COMPARTMENTS Subcellular localization image for IFNA14 gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IFNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA14: view

Pathways for IFNA14 Gene

genes like me logo Genes that share pathways with IFNA14: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat

Gene Ontology (GO) - Biological Process for IFNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA14: view

Transcripts for IFNA14 Gene

mRNA/cDNA for IFNA14 Gene

(6) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA14

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IFNA14
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA14 Gene

No ASD Table

Relevant External Links for IFNA14 Gene

GeneLoc Exon Structure for
IFNA14
ECgene alternative splicing isoforms for
IFNA14

Expression for IFNA14 Gene

mRNA expression in normal human tissues for IFNA14 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA14 Gene

This gene is overexpressed in Kidney - Cortex (38.0), Cervix - Ectocervix (5.8), and Testis (4.5).

SOURCE GeneReport for Unigene cluster for IFNA14 Gene Hs.93907

genes like me logo Genes that share expressions with IFNA14: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for IFNA14 Gene

Orthologs for IFNA14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA14 35
  • 98.77 (n)
  • 98.41 (a)
IFNA14 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
IFNAA 36
  • 61 (a)
ManyToMany
IFNAG 36
  • 62 (a)
ManyToMany
IFNAG 36
  • 63 (a)
ManyToMany
IFNAH 36
  • 61 (a)
ManyToMany
INFAF 36
  • 61 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 36
  • 59 (a)
ManyToMany
Gm13280 36
  • 59 (a)
ManyToMany
Ifna1 36
  • 60 (a)
ManyToMany
Ifna11 36
  • 57 (a)
ManyToMany
Ifna12 36
  • 60 (a)
ManyToMany
Ifna13 36
  • 61 (a)
ManyToMany
Ifna14 36
  • 57 (a)
ManyToMany
Ifna2 36
  • 57 (a)
ManyToMany
Ifna4 36
  • 55 (a)
ManyToMany
Ifna5 36
  • 60 (a)
ManyToMany
Ifna6 36
  • 61 (a)
ManyToMany
Ifna7 36
  • 57 (a)
ManyToMany
Ifna9 36
  • 61 (a)
ManyToMany
Ifnab 36
  • 58 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifna5 35
  • 73.37 (n)
  • 58.15 (a)
Species with no ortholog for IFNA14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA14 Gene

ENSEMBL:
Gene Tree for IFNA14 (if available)
TreeFam:
Gene Tree for IFNA14 (if available)

Paralogs for IFNA14 Gene

Selected SIMAP similar genes for IFNA14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA14: view

Variants for IFNA14 Gene

Sequence variations from dbSNP and Humsavar for IFNA14 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs702212 -- 21,239,413(-) GATCC(C/T)TCTCT reference, missense
rs4628333 -- 21,238,963(+) TTGAC(A/G)TTTTA downstream-variant-500B
rs7868193 -- 21,239,996(+) GGTTG(C/T)AGGTT upstream-variant-2KB
rs10964931 -- 21,241,652(+) GCAGG(A/G)CACCA upstream-variant-2KB
rs10964932 -- 21,241,857(+) CCAAG(A/T)TGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNA14 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294

Relevant External Links for IFNA14 Gene

HapMap Linkage Disequilibrium report
IFNA14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA14 Gene

Disorders for IFNA14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for IFNA14 Gene including...

Search for IFNA14 Gene in MalaCards »

Relevant External Links for IFNA14

Genetic Association Database (GAD)
IFNA14
Human Genome Epidemiology (HuGE) Navigator
IFNA14
genes like me logo Genes that share disorders with IFNA14: view

No data available for UniProtKB/Swiss-Prot for IFNA14 Gene

Publications for IFNA14 Gene

  1. Structural relationship of human interferon alpha genes and pseudogenes. (PMID: 4057246) Henco K. … Weissmann C. (J. Mol. Biol. 1985) 3 4
  2. The structure of eight distinct cloned human leukocyte interferon cDNAs. (PMID: 6163083) Goeddel D.V. … Gray P.W. (Nature 1981) 3 4
  3. DNA sequence of two closely linked human leukocyte interferon genes. (PMID: 6165082) Lawn R.M. … Ullrich A. (Science 1981) 3 4
  4. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  5. Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (PMID: 8910771) Hussain M. … Liao M.-J. (J. Interferon Cytokine Res. 1996) 3 4

Products for IFNA14 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Interferons & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNA14
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA14
    • Block miRNA regulation of IFNA14 using miScript Target Protectors

    Sources for IFNA14 Gene

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