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Aliases for IFNA14 Gene

Aliases for IFNA14 Gene

  • Interferon Alpha 14 2 3
  • Interferon, Alpha 14 2 3 5
  • Interferon Lambda-2-H 3 4
  • Interferon Alpha-H 3 4
  • IFN-Alpha-14 3 4
  • LeIF H 3 4
  • IFN-AlphaH 3
  • LEIF2H 3

External Ids for IFNA14 Gene

Previous GeneCards Identifiers for IFNA14 Gene

  • GC09M021566
  • GC09M021403
  • GC09M021192
  • GC09M021229
  • GC09M021193
  • GC09M021194
  • GC09M021208
  • GC09M021211

Summaries for IFNA14 Gene

GeneCards Summary for IFNA14 Gene

IFNA14 (Interferon Alpha 14) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Allograft rejection. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA14 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA14 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA14 Gene

Genomics for IFNA14 Gene

Regulatory Elements for IFNA14 Gene

Enhancers for IFNA14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFNA14 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNA14 Gene

21,239,002 bp from pter
21,239,991 bp from pter
990 bases
Minus strand

Genomic View for IFNA14 Gene

Genes around IFNA14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA14 Gene

Proteins for IFNA14 Gene

  • Protein details for IFNA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-14
    Protein Accession:
    Secondary Accessions:
    • Q5VZ56
    • Q7M4S1

    Protein attributes for IFNA14 Gene

    189 amino acids
    Molecular mass:
    22063 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA14 Gene

Proteomics data for IFNA14 Gene at MOPED

Post-translational modifications for IFNA14 Gene

Other Protein References for IFNA14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA14 Gene

Domains & Families for IFNA14 Gene

Gene Families for IFNA14 Gene

Suggested Antigen Peptide Sequences for IFNA14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA14: view

Function for IFNA14 Gene

Molecular function for IFNA14 Gene

GENATLAS Biochemistry:
interferon type I,alpha 14,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
genes like me logo Genes that share phenotypes with IFNA14: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA14 Gene

Localization for IFNA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA14 Gene


Subcellular locations from

Jensen Localization Image for IFNA14 Gene COMPARTMENTS Subcellular localization image for IFNA14 gene
Compartment Confidence
extracellular 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for IFNA14 Gene

Pathways & Interactions for IFNA14 Gene

genes like me logo Genes that share pathways with IFNA14: view

Gene Ontology (GO) - Biological Process for IFNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
GO:0007596 blood coagulation TAS --
GO:0019221 cytokine-mediated signaling pathway IBA,TAS --
genes like me logo Genes that share ontologies with IFNA14: view

No data available for SIGNOR curated interactions for IFNA14 Gene

Drugs & Compounds for IFNA14 Gene

No Compound Related Data Available

Transcripts for IFNA14 Gene

mRNA/cDNA for IFNA14 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA14 Gene

No ASD Table

Relevant External Links for IFNA14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA14 Gene

mRNA expression in normal human tissues for IFNA14 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA14 Gene

This gene is overexpressed in Kidney - Cortex (x38.0), Cervix - Ectocervix (x5.8), and Testis (x4.5).

SOURCE GeneReport for Unigene cluster for IFNA14 Gene Hs.93907

genes like me logo Genes that share expression patterns with IFNA14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFNA14 Gene

Orthologs for IFNA14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNA14 35
  • 98.77 (n)
  • 98.41 (a)
IFNA14 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ifna5 35
  • 73.37 (n)
  • 58.15 (a)
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
-- 36
  • 61 (a)
-- 36
  • 63 (a)
-- 36
  • 61 (a)
-- 36
  • 62 (a)
  • 61 (a)
  • 62 (a)
  • 63 (a)
  • 61 (a)
  • 61 (a)
(Mus musculus)
Mammalia Gm12597 36
  • 59 (a)
Gm13280 36
  • 59 (a)
Ifna1 36
  • 60 (a)
Ifna11 36
  • 57 (a)
Ifna12 36
  • 60 (a)
Ifna13 36
  • 61 (a)
Ifna14 36
  • 57 (a)
Ifna2 36
  • 57 (a)
Ifna4 36
  • 55 (a)
Ifna5 36
  • 60 (a)
Ifna6 36
  • 61 (a)
Ifna7 36
  • 57 (a)
Ifna9 36
  • 61 (a)
Ifnab 36
  • 58 (a)
Species with no ortholog for IFNA14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA14 Gene

Gene Tree for IFNA14 (if available)
Gene Tree for IFNA14 (if available)

Paralogs for IFNA14 Gene

(19) SIMAP similar genes for IFNA14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA14: view

Variants for IFNA14 Gene

Sequence variations from dbSNP and Humsavar for IFNA14 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs702212 -- 21,239,413(-) GATCC(C/T)TCTCT reference, missense
rs113038943 -- 21,239,138(+) AATAA(A/G)TAAAT downstream-variant-500B
rs7868193 -- 21,239,996(+) GGTTG(C/T)AGGTT upstream-variant-2KB
rs113581777 -- 21,238,962(+) CTTGA(C/T)GTTTT downstream-variant-500B
rs113650850 -- 21,241,574(+) GGAAA(C/T)CCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNA14 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294

Variation tolerance for IFNA14 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IFNA14 Gene

Disorders for IFNA14 Gene

Relevant External Links for IFNA14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IFNA14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA14 Gene

Publications for IFNA14 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 48 67
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  3. HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms. (PMID: 25972534) Reszka-Blanco N.J. … Su L. (J. Virol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Evidence for a different susceptibility of primate lentiviruses to type I interferons. (PMID: 23255800) Cordeil S. … Cimarelli A. (J. Virol. 2013) 3

Products for IFNA14 Gene

Sources for IFNA14 Gene