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Aliases for IFNA14 Gene

Aliases for IFNA14 Gene

  • Interferon Alpha 14 2 3 5
  • Interferon Lambda-2-H 3 4
  • Interferon Alpha-H 3 4
  • IFN-Alpha-14 3 4
  • LeIF H 3 4
  • Interferon, Alpha 14 2
  • Interferon Alpha-14 3
  • IFN-AlphaH 3
  • LEIF2H 3

External Ids for IFNA14 Gene

Previous GeneCards Identifiers for IFNA14 Gene

  • GC09M021566
  • GC09M021403
  • GC09M021192
  • GC09M021229
  • GC09M021193
  • GC09M021194
  • GC09M021208
  • GC09M021211

Summaries for IFNA14 Gene

GeneCards Summary for IFNA14 Gene

IFNA14 (Interferon Alpha 14) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA5.

UniProtKB/Swiss-Prot for IFNA14 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA14 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA14 Gene

Genomics for IFNA14 Gene

Regulatory Elements for IFNA14 Gene

Enhancers for IFNA14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F021235 0.8 Ensembl ENCODE 0.8 +3.9 3917 0.7 ZNF664 CTCF ZNF654 SMC3 TRIM22 RAD21 IFNA20P IFNA14 IFNWP5
GH09F021252 0.9 Ensembl ENCODE 0.4 -13.2 -13213 0.8 CTCF PKNOX1 ZNF654 TRIM22 RAD21 SMARCA4 SMC3 PRDM1 IFNA12P IFNA8 IFNWP2 IFNA13 IFNA20P IFNA14 IFNA22P
GH09F021268 0.6 Ensembl 0.3 -28.2 -28210 0.4 MTA2 IKZF1 CBX2 BMI1 EBF1 TBX21 SPI1 IFNA5 IFNA12P IFNA8 IFNWP2 IFNA13 MIR31 IFNA22P IFNA14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFNA14 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNA14 Gene

Chromosome:
9
Start:
21,239,002 bp from pter
End:
21,239,991 bp from pter
Size:
990 bases
Orientation:
Minus strand

Genomic View for IFNA14 Gene

Genes around IFNA14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA14 Gene

Proteins for IFNA14 Gene

  • Protein details for IFNA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01570-IFN14_HUMAN
    Recommended name:
    Interferon alpha-14
    Protein Accession:
    P01570
    Secondary Accessions:
    • Q5VZ56
    • Q7M4S1

    Protein attributes for IFNA14 Gene

    Size:
    189 amino acids
    Molecular mass:
    22063 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA14 Gene

Post-translational modifications for IFNA14 Gene

  • Glycosylation at Asn 95
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNA14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA14 Gene

Domains & Families for IFNA14 Gene

Gene Families for IFNA14 Gene

Suggested Antigen Peptide Sequences for IFNA14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01570

UniProtKB/Swiss-Prot:

IFN14_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA14: view

Function for IFNA14 Gene

Molecular function for IFNA14 Gene

GENATLAS Biochemistry:
interferon type I,alpha 14,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding IEA,TAS 6163083
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA14: view
genes like me logo Genes that share phenotypes with IFNA14: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA14 Gene

Localization for IFNA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA14 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA14 gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IFNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA14: view

Pathways & Interactions for IFNA14 Gene

genes like me logo Genes that share pathways with IFNA14: view

Gene Ontology (GO) - Biological Process for IFNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA14: view

No data available for SIGNOR curated interactions for IFNA14 Gene

Transcripts for IFNA14 Gene

mRNA/cDNA for IFNA14 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA14 Gene

No ASD Table

Relevant External Links for IFNA14 Gene

GeneLoc Exon Structure for
IFNA14
ECgene alternative splicing isoforms for
IFNA14

Expression for IFNA14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA14 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA14 Gene

This gene is overexpressed in Kidney - Cortex (x38.0), Cervix - Ectocervix (x5.8), and Testis (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of IFNA14 Gene:

IFNA14

SOURCE GeneReport for Unigene cluster for IFNA14 Gene:

Hs.93907
genes like me logo Genes that share expression patterns with IFNA14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IFNA14 Gene

Orthologs for IFNA14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA14 34 35
  • 98.77 (n)
rat
(Rattus norvegicus)
Mammalia Ifna5 34
  • 73.37 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 63 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
IFNAG 35 35
  • 62 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
IFNAA 35
  • 61 (a)
ManyToMany
IFNAH 35
  • 61 (a)
ManyToMany
INFAF 35
  • 61 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ifna13 35
  • 61 (a)
ManyToMany
Ifna6 35
  • 61 (a)
ManyToMany
Ifna9 35
  • 61 (a)
ManyToMany
Ifna1 35
  • 60 (a)
ManyToMany
Ifna12 35
  • 60 (a)
ManyToMany
Ifna5 35
  • 60 (a)
ManyToMany
Gm12597 35
  • 59 (a)
ManyToMany
Gm13280 35
  • 59 (a)
ManyToMany
Ifnab 35
  • 58 (a)
ManyToMany
Ifna11 35
  • 57 (a)
ManyToMany
Ifna14 35
  • 57 (a)
ManyToMany
Ifna2 35
  • 57 (a)
ManyToMany
Ifna7 35
  • 57 (a)
ManyToMany
Ifna4 35
  • 55 (a)
ManyToMany
Species where no ortholog for IFNA14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA14 Gene

ENSEMBL:
Gene Tree for IFNA14 (if available)
TreeFam:
Gene Tree for IFNA14 (if available)

Paralogs for IFNA14 Gene

(19) SIMAP similar genes for IFNA14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA14: view

Variants for IFNA14 Gene

Sequence variations from dbSNP and Humsavar for IFNA14 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10964931 -- 21,241,652(+) GCAGG(A/G)CACCA upstream-variant-2KB
rs10964932 -- 21,241,857(+) CCAAG(A/T)TGGAG upstream-variant-2KB
rs111391367 -- 21,240,434(+) CCAAC(A/C)TGGTG upstream-variant-2KB
rs111726417 -- 21,239,765(+) AAGTC(A/G/T)TGTCT reference, synonymous-codon, missense
rs112966614 -- 21,240,446(+) AACCC(C/G/T)GTCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFNA14 Gene

Variant ID Type Subtype PubMed ID
nsv968599 CNV duplication 23825009
nsv1035128 CNV gain 25217958
esv3619957 CNV loss 21293372
esv3619956 CNV loss 21293372
esv2764150 CNV gain+loss 21179565

Variation tolerance for IFNA14 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA14 Gene

Disorders for IFNA14 Gene

Relevant External Links for IFNA14

Genetic Association Database (GAD)
IFNA14
Human Genome Epidemiology (HuGE) Navigator
IFNA14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA14

No disorders were found for IFNA14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA14 Gene

Publications for IFNA14 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64
  2. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64
  3. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 46 64
  4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 64
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen C.L. … Janssen R. (Pediatr. Infect. Dis. J. 2009) 3 46 64

Products for IFNA14 Gene

Sources for IFNA14 Gene

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