Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IFNA13 Gene

Aliases for IFNA13 Gene

  • Interferon Alpha 13 2 3 5
  • Interferon Alpha-D 3 4
  • IFN-Alpha-1/13 3 4
  • LeIF D 3 4
  • Interferon Alpha-1/13 3
  • IFNA1 IFNA13 4

External Ids for IFNA13 Gene

Previous GeneCards Identifiers for IFNA13 Gene

  • GC09M021695
  • GC09M021568

Summaries for IFNA13 Gene

GeneCards Summary for IFNA13 Gene

IFNA13 (Interferon Alpha 13) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA1.

UniProtKB/Swiss-Prot for IFNA13 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA13 Gene

Genomics for IFNA13 Gene

Regulatory Elements for IFNA13 Gene

Enhancers for IFNA13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F021334 0.5 ENCODE 12 +33.9 33875 1.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 IFNA13 IFNA5 IFNA12P IFNA8 IFNWP2 KLHL9 IFNA20P
GH09F021333 0.2 ENCODE 11.8 +35.0 34966 0.2 CHD1 IFNA13 IFNA5 IFNA12P IFNA8 IFNWP2 KLHL9 IFNA20P
GH09F021450 0.2 ENCODE 11.1 -82.6 -82621 1.4 CEBPB NFE2L2 IFNWP2 IFNA8 IFNA12P IFNA13 IFNA5 IFNWP19
GH09F021294 0.5 Ensembl ENCODE 11 +74.5 74462 0.2 TBP JUN CEBPB MAX USF2 EP300 JUND SCRT2 FOS TCF7L2 IFNA13 IFNA5 IFNA22P
GH09F021296 0.7 Ensembl 11 +72.7 72662 0.2 IFNA13 IFNA20P IFNA5 IFNA22P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IFNA13 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNA13 Gene

Chromosome:
9
Start:
21,367,372 bp from pter
End:
21,368,962 bp from pter
Size:
1,591 bases
Orientation:
Minus strand

Genomic View for IFNA13 Gene

Genes around IFNA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA13 Gene

Proteins for IFNA13 Gene

  • Protein details for IFNA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01562-IFNA1_HUMAN
    Recommended name:
    Interferon alpha-1/13
    Protein Accession:
    P01562
    Secondary Accessions:
    • D4Q9M8
    • Q14605
    • Q2M1L8
    • Q52LB8
    • Q5VYQ2
    • Q7M4Q1
    • Q8WZ68
    • Q9UMJ3

    Protein attributes for IFNA13 Gene

    Size:
    189 amino acids
    Molecular mass:
    21725 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Interferons alpha-1 and alpha-13 have identical protein sequences.

    Three dimensional structures from OCA and Proteopedia for IFNA13 Gene

neXtProt entry for IFNA13 Gene

Post-translational modifications for IFNA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IFNA13
  • Cloud-Clone Corp. Antibodies for IFNA13

No data available for DME Specific Peptides for IFNA13 Gene

Domains & Families for IFNA13 Gene

Gene Families for IFNA13 Gene

Suggested Antigen Peptide Sequences for IFNA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01562

UniProtKB/Swiss-Prot:

IFNA1_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA13: view

Function for IFNA13 Gene

Molecular function for IFNA13 Gene

GENATLAS Biochemistry:
interferon type I,alpha 13,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA13: view
genes like me logo Genes that share phenotypes with IFNA13: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA13 Gene

Localization for IFNA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA13 Gene COMPARTMENTS Subcellular localization image for IFNA13 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA13: view

Pathways & Interactions for IFNA13 Gene

genes like me logo Genes that share pathways with IFNA13: view

SIGNOR curated interactions for IFNA13 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IFNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA13: view

Transcripts for IFNA13 Gene

mRNA/cDNA for IFNA13 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNA13 Gene

Interferon, alpha 13:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA13 Gene

No ASD Table

Relevant External Links for IFNA13 Gene

GeneLoc Exon Structure for
IFNA13
ECgene alternative splicing isoforms for
IFNA13

Expression for IFNA13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA13 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA13 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.3) and Brain - Hippocampus (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of IFNA13 Gene:

IFNA13

SOURCE GeneReport for Unigene cluster for IFNA13 Gene:

Hs.533471
genes like me logo Genes that share expression patterns with IFNA13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IFNA13 Gene

Orthologs for IFNA13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA13 34
  • 99.29 (n)
-- 35
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifna13 35
  • 64 (a)
ManyToMany
Ifna6 35
  • 64 (a)
ManyToMany
Ifna9 35
  • 64 (a)
ManyToMany
Ifna5 35
  • 63 (a)
ManyToMany
Gm12597 35
  • 62 (a)
ManyToMany
Gm13280 35
  • 62 (a)
ManyToMany
Ifna1 35
  • 62 (a)
ManyToMany
Ifna12 35
  • 62 (a)
ManyToMany
Ifna14 35
  • 60 (a)
ManyToMany
Ifna4 35
  • 60 (a)
ManyToMany
Ifna7 35
  • 60 (a)
ManyToMany
Ifna11 35
  • 59 (a)
ManyToMany
Ifna2 35
  • 59 (a)
ManyToMany
Ifnab 35
  • 59 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 63 (a)
ManyToMany
IFNAG 35 35
  • 63 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
IFNAA 35
  • 62 (a)
ManyToMany
INFAF 35
  • 62 (a)
ManyToMany
IFNAH 35
  • 61 (a)
ManyToMany
Species where no ortholog for IFNA13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA13 Gene

ENSEMBL:
Gene Tree for IFNA13 (if available)
TreeFam:
Gene Tree for IFNA13 (if available)

Paralogs for IFNA13 Gene

(18) SIMAP similar genes for IFNA13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFNA13: view

Variants for IFNA13 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA13 Gene

IFNA1_HUMAN-P01562
Two forms exist; alpha-1a (shown here) and alpha-1b (PubMed:11032395).

Sequence variations from dbSNP and Humsavar for IFNA13 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10116363 -- 21,368,667(+) cattt(A/C)ttttt upstream-variant-2KB
rs10116429 -- 21,368,925(+) tatgt(A/G)tgcag upstream-variant-2KB
rs10156589 -- 21,368,216(+) ctcaa(C/T)cattt upstream-variant-2KB
rs111856715 -- 21,368,191(+) TTTAC(A/G)TGAGT upstream-variant-2KB
rs111943210 -- 21,367,435(+) ACCAG(A/G)TGTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IFNA13 Gene

Variant ID Type Subtype PubMed ID
esv2752289 CNV gain 17911159
esv2764150 CNV gain+loss 21179565
nsv972300 CNV duplication 23825009

Variation tolerance for IFNA13 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA13

Disorders for IFNA13 Gene

Relevant External Links for IFNA13

Genetic Association Database (GAD)
IFNA13
Human Genome Epidemiology (HuGE) Navigator
IFNA13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA13

No disorders were found for IFNA13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA13 Gene

Publications for IFNA13 Gene

  1. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64
  2. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 64
  3. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen C.L. … Janssen R. (Pediatr. Infect. Dis. J. 2009) 3 46 64
  4. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PMID: 17703412) Janssen R. … Hoebee B. (J. Infect. Dis. 2007) 3 46 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64

Products for IFNA13 Gene

Sources for IFNA13 Gene

Content
Loading form....