IFNA13 Gene
protein-coding GIFtS: 53
GCID: GC09M021357
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|
interferon, alpha 13
| |
Aliases
for IFNA13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon, Alpha 131 2 | | Interferon Alpha-D2 3 | | LeIF D2 3 | | IFN-Alpha-1/131 | | Interferon Alpha-1/132 |
Export aliases for IFNA13 gene to outside databasesPrevious GC identifers: GC09M021695 GC09M021568 |
Summaries
for IFNA13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase
Gene Wiki entry for IFNA13
|
Genomic Views
for IFNA13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFNA13 gene promoter:
Egr-3 Egr-2 IRF-7A NF-kappaB1 NF-kappaB Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFNA13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22IFNA13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M021357: view genomic region
(about GC identifiers)
Start:
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21,367,371 bp from pter |
End:
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21,368,075 bp from pter |
Size:
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705 bases |
Orientation:
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minus strand |
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Proteins
for IFNA13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562 (See
protein sequence)Recommended Name: Interferon alpha-1/13 precursor Size: 189 amino acids; 21725 Da
Subcellular location: Secreted
Miscellaneous: Interferons alpha-1 and alpha-13 have identical protein sequences
1 PDB 3D structure from  and Proteopedia  for IFNA13:3UX9 (3D)
Secondary accessions: D4Q9M8 Q14605 Q2M1L8 Q52LB8 Q5VYQ2 Q7M4Q1 Q8WZ68 Q9UMJ3Explore the universe of human proteins at neXtProt for IFNA13: NX_P01562
Post-translational modifications:
View modification sites using PhosphoSitePlus2 (IFNA13)View neXtProt modification sites for NX_P01562
IFNA13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008831.3
ENSEMBL proteins: ENSP00000394494 Reactome Protein details: P01562
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005615 | extracellular space |
IEA | -- |
IFNA13 for ontologies About GeneDecksing
IFNA13 Antibody Products:
Assay Products for IFNA13: |
Protein
Domains /
Families
for IFNA13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFNA13 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P01562ProtoNet protein and cluster: P01562 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562Similarity: Belongs to the alpha/beta interferon family |
Function
for IFNA13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase Genatlas biochemistry entry for IFNA13:interferon type I,alpha 13,leukocyte
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA13 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA13 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNA13 (NM_006900) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA13 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
IFNA13 for ontologies About GeneDecksing
|
Pathways & Interactions
for IFNA13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of IFNA signaling | | | 2 | Toll-like receptor signaling pathway | | | 3 | Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway | | | 4 | Measles | | | 5 | all-trans-Retinoic Acid Mediated Apoptosis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for IFNA13
1  R&D Systems Pathway for IFNA13
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA13
2  GeneGo (Thomson Reuters) Pathways for IFNA13
1  BioSystems Pathway for IFNA13
5/11 
Reactome Pathways for IFNA13 (see all 11)
5/12 
Kegg Pathways (Kegg details for IFNA13) (see all 12):
IFNA13 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA13
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/8 Interacting proteins for IFNA13 (P015623 ENSP000003944944) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
IFNA13 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFNA13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IFNA13
Search CenterWatch for drugs/clinical trials and news about IFNA13 / IFNA1
|
Transcripts
for IFNA13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IFNA13 gene: NM_006900.3 Unigene Cluster for IFNA13: Interferon, alpha 13 Hs.533471 Unigene Representative Sequence: NM_0069001 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000449498(uc003zpa.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA13 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA13 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IFNA13 (NM_006900) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA13 |
Additional cDNA sequence: BC069427.1 BC093988.1 1 DOTS entry: DT.121155340 2 AceView cDNA sequences: NM_006900 BC069427
GeneLoc Exon Structure
|
Expression
for IFNA13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFNA13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATCCCTCT
About this image
See IFNA13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA13
SOURCE GeneReport for Unigene cluster: Hs.533471
SABiosciences Custom PCR Arrays for IFNA13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA13
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IFNA13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA13 |
Orthologs
for IFNA13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFNA13 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for IFNA13 (if available)
TreeFam Gene Tree for IFNA13 (if available) |
Paralogs
for IFNA13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IFNA13 gene
- IFNA11 2 IFNA72 IFNA22 IFNE2 IFNA42 IFNA142 IFNA52 IFNK2
- IFNA212 IFNA172 IFNA62 IFNB12 IFNW12 IFNA162 IFNA102 IFNA82
18 SIMAP similar genes for IFNA13 using alignment to 2 protein entries: IFNA1_HUMAN (see all proteins):IFNA1 IFNA5 IFNA10 IFNA14 IFNA17 IFNA21
IFNA4 IFNA6 IFNA7 IFN-2 IFNA IFNA2
IFNA2B IFNA16 IFNA8 IFNW1 IFNE IFNB1
IFNA13 for paralogs About GeneDecksing
|
Genomic Variants
for IFNA13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562Polymorphism: Two forms exist; alpha-1a (shown here) and alpha-1b
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IFNA13 (21367371 - 21368075 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFNA13
1 CNV: 8623 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA13 |
|
Disorders
/ Diseases
for IFNA13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFNA13 for disorders About GeneDecksing
OMIM gene information: 147578
OMIM disorders: --
13  diseases for IFNA13: About MalaCardsdengue hemorrhagic fever hemorrhagic fever bronchiolitis autoimmune thyroiditis
hepatitis c hepatitis b measles hepatitis
influenza thyroiditis tuberculosis systemic lupus erythematosus
lupus erythematosus
Human Genome Epidemiology (HuGE) Navigator: IFNA13 (23 documents)
Export disorders for IFNA13 gene to outside databases
|
Publications
for IFNA13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFNA13 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with IFNA13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- IFN-alpha-1a gene is the major variant in the North American population. (PubMed id 11032395)1, 2 Hussain M.... Liao M.-J. (2000)
- Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (1998)
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
- Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)1, 2 Henco K.... Weissmann C. (1985)
- Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides. (PubMed id 2985969)1, 2 Capon D.J.... Goeddel D.V. (1985)
- Two non-allelic human interferon alpha genes with identical coding regions. (PubMed id 6479148)1, 2 Todokoro K.... Weissmann C. (1984)
- Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli. (PubMed id 6310510)1, 2 Weber H. and Weissmann C. (1983)
- The structure of eight distinct cloned human leukocyte interferon cDNAs. (PubMed id 6163083)1, 2 Goeddel D.V.... Gray P.W. (1981)
|
External Searches for IFNA13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFNA13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFNA13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNA13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for IFNA13 gene:
Search GeneIP for patents involving IFNA13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFNA13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IFNA13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNA13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA13 | | | OriGene Protein Over-expression Lysate for IFNA13 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IFNA13 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNA13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA13 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for IFNA13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA13 |
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