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Aliases for IFNA13 Gene

Aliases for IFNA13 Gene

  • Interferon, Alpha 13 2 3
  • Interferon Alpha-D 3 4
  • IFN-Alpha-1/13 3 4
  • LeIF D 3 4
  • Interferon Alpha-1/13 3
  • IFNA1 IFNA13 4

External Ids for IFNA13 Gene

Previous GeneCards Identifiers for IFNA13 Gene

  • GC09M021695
  • GC09M021568

Summaries for IFNA13 Gene

GeneCards Summary for IFNA13 Gene

IFNA13 (Interferon, Alpha 13) is a Protein Coding gene. Diseases associated with IFNA13 include dengue hemorrhagic fever and hiv-1. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA13 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA13 Gene

Genomics for IFNA13 Gene

Regulatory Elements for IFNA13 Gene

Genomic Location for IFNA13 Gene

Start:
21,367,372 bp from pter
End:
21,368,962 bp from pter
Size:
1,591 bases
Orientation:
Minus strand

Genomic View for IFNA13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA13 Gene

Proteins for IFNA13 Gene

  • Protein details for IFNA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01562-IFNA1_HUMAN
    Recommended name:
    Interferon alpha-1/13
    Protein Accession:
    P01562
    Secondary Accessions:
    • D4Q9M8
    • Q14605
    • Q2M1L8
    • Q52LB8
    • Q5VYQ2
    • Q7M4Q1
    • Q8WZ68
    • Q9UMJ3

    Protein attributes for IFNA13 Gene

    Size:
    189 amino acids
    Molecular mass:
    21725 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Interferons alpha-1 and alpha-13 have identical protein sequences

    Three dimensional structures from OCA and Proteopedia for IFNA13 Gene

neXtProt entry for IFNA13 Gene

Proteomics data for IFNA13 Gene at MOPED

Post-translational modifications for IFNA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA13 Gene

Domains for IFNA13 Gene

Gene Families for IFNA13 Gene

HGNC:
  • IFN :Interferons

Suggested Antigen Peptide Sequences for IFNA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01562

UniProtKB/Swiss-Prot:

IFNA1_HUMAN :
  • P01562
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA13: view

Function for IFNA13 Gene

Molecular function for IFNA13 Gene

GENATLAS Biochemistry: interferon type I,alpha 13,leukocyte
UniProtKB/Swiss-Prot Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA13: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNA13 Gene

Localization for IFNA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA13 Gene COMPARTMENTS Subcellular localization image for IFNA13 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA13: view

Pathways for IFNA13 Gene

genes like me logo Genes that share pathways with IFNA13: view

Interacting Proteins for IFNA13 Gene

Gene Ontology (GO) - Biological Process for IFNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA13: view

Transcripts for IFNA13 Gene

mRNA/cDNA for IFNA13 Gene

(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNA13 Gene

Interferon, alpha 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA13

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IFNA13
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA13 Gene

No ASD Table

Relevant External Links for IFNA13 Gene

GeneLoc Exon Structure for
IFNA13
ECgene alternative splicing isoforms for
IFNA13

Expression for IFNA13 Gene

mRNA expression in normal human tissues for IFNA13 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA13 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (5.3) and Brain - Hippocampus (4.9).

SOURCE GeneReport for Unigene cluster for IFNA13 Gene Hs.533471

genes like me logo Genes that share expressions with IFNA13: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for IFNA13 Gene

Orthologs for IFNA13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
OneToMany
IFNA13 35
  • 99.29 (n)
  • 98.94 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
IFNAA 36
  • 62 (a)
ManyToMany
IFNAG 36
  • 63 (a)
ManyToMany
IFNAG 36
  • 63 (a)
ManyToMany
IFNAH 36
  • 61 (a)
ManyToMany
INFAF 36
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 36
  • 62 (a)
ManyToMany
Gm13280 36
  • 62 (a)
ManyToMany
Ifna1 36
  • 62 (a)
ManyToMany
Ifna11 36
  • 59 (a)
ManyToMany
Ifna12 36
  • 62 (a)
ManyToMany
Ifna13 36
  • 64 (a)
ManyToMany
Ifna14 36
  • 60 (a)
ManyToMany
Ifna2 36
  • 59 (a)
ManyToMany
Ifna4 36
  • 60 (a)
ManyToMany
Ifna5 36
  • 63 (a)
ManyToMany
Ifna6 36
  • 64 (a)
ManyToMany
Ifna7 36
  • 60 (a)
ManyToMany
Ifna9 36
  • 64 (a)
ManyToMany
Ifnab 36
  • 59 (a)
ManyToMany
Species with no ortholog for IFNA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA13 Gene

ENSEMBL:
Gene Tree for IFNA13 (if available)
TreeFam:
Gene Tree for IFNA13 (if available)

Paralogs for IFNA13 Gene

Selected SIMAP similar genes for IFNA13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFNA13: view

Variants for IFNA13 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA13 Gene

P01562-IFNA1_HUMAN
Two forms exist; alpha-1a (shown here) and alpha-1b

Sequence variations from dbSNP and Humsavar for IFNA13 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs637949 -- 21,369,316(-) TGAAG(C/G)CACCT upstream-variant-2KB
rs641734 -- 21,368,928(-) cctct(A/G)catac upstream-variant-2KB
rs643070 -- 21,368,610(-) cataa(A/G)cattc upstream-variant-2KB
rs653778 -- 21,368,098(-) AAGGC(A/T)TCTGC upstream-variant-2KB
rs1224392 -- 21,366,909(+) TGATA(C/T)TAAGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IFNA13 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892736 CNV Gain 21882294
nsv892737 CNV Loss 21882294
esv2752289 CNV Gain 17911159

Relevant External Links for IFNA13 Gene

HapMap Linkage Disequilibrium report
IFNA13

Disorders for IFNA13 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for IFNA13 Gene including...

Search for IFNA13 Gene in MalaCards »

Relevant External Links for IFNA13

Genetic Association Database (GAD)
IFNA13
Human Genome Epidemiology (HuGE) Navigator
IFNA13
genes like me logo Genes that share disorders with IFNA13: view

No data available for UniProtKB/Swiss-Prot for IFNA13 Gene

Publications for IFNA13 Gene

  1. The structure of eight distinct cloned human leukocyte interferon cDNAs. (PMID: 6163083) Goeddel D.V. … Gray P.W. (Nature 1981) 3 4
  2. Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli. (PMID: 6310510) Weber H. … Weissmann C. (Nucleic Acids Res. 1983) 3 4
  3. Two non-allelic human interferon alpha genes with identical coding regions. (PMID: 6479148) Todokoro K. … Weissmann C. (EMBO J. 1984) 3 4
  4. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  5. Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides. (PMID: 2985969) Capon D.J. … Goeddel D.V. (Mol. Cell. Biol. 1985) 3 4

Products for IFNA13 Gene

Sources for IFNA13 Gene

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