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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IFNA10 Gene

protein-coding   GIFtS: 57
GCID: GC09M021248

Interferon, Alpha 10

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon, Alpha 101 2     IFN-alpha-102 3
Interferon Alpha-6L2 3     IFN-alphaC2
Interferon Alpha-C2 3     Interferon Alpha-102
LeIF C2 3     

External Ids:    HGNC: 54181   Entrez Gene: 34462   Ensembl: ENSG000001868037   OMIM: 1475775   UniProtKB: P015663   

Export aliases for IFNA10 gene to outside databases

Previous GC identifers: GC09M021533 GC09M021407 GC09M021196 GC09M021215 GC09M021225 GC09M021175 GC09M021232 GC09M021235 GC09M021238 GC09M021242 GC09M021245


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNA10 Gene:
This gene encodes a protein that belongs to the type I interferon family of proteins, and is located in a cluster
of alpha interferon genes on chromosome 9. Interferons are small regulatory molecules that function in cell
signaling in response to viruses and other pathogens or tumor cells. This gene is intronless and the encoded
protein is secreted. (provided by RefSeq, Aug 2013)

GeneCards Summary for IFNA10 Gene: 
IFNA10 (interferon, alpha 10) is a protein-coding gene. Diseases associated with IFNA10 include pulmonary sarcoidosis, and hepatitis d, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include cytokine receptor binding and cytokine activity. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFN10_HUMAN, P01566
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IFNA10 gene promoter:
         Egr-3   Egr-2   IRF-7A   Egr-4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IFNA10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA10 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021248:  view genomic region     (about GC identifiers)

Start:
21,206,180 bp from pter      End:
21,207,142 bp from pter
Size:
963 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IFN10_HUMAN, P01566 (See protein sequence)
Recommended Name: Interferon alpha-10 precursor  
Size: 189 amino acids; 21835 Da
Subcellular location: Secreted
Secondary accessions: Q5VV13

Explore the universe of human proteins at neXtProt for IFNA10: NX_P01566

Explore proteomics data for IFNA10 at MOPED 

IFNA10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IFNA10 Protein Expression

REFSEQ proteins: NP_002162.1  
ENSEMBL proteins: 
 ENSP00000369566  
Reactome Protein details: P01566
Human Recombinant Protein Products for IFNA10: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IFNA10 (IFN-alpha C)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for IFNA10
OriGene Protein Over-expression Lysate for IFNA10
OriGene MassSpec for IFNA10 
OriGene Custom Protein Services for IFNA10
GenScript Custom Purified and Recombinant Proteins Services for IFNA10
Novus Biologicals IFNA10 Protein
Novus Biologicals IFNA10 Lysates
Sino Biological Recombinant Protein for IFNA10
Sino Biological Cell Lysate for IFNA10 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

IFNA10 for ontologies           About GeneDecksing



IFNA10 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
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OriGene Custom Antibody Services for IFNA10
GenScript Custom Superior Antibodies Services for IFNA10
Novus Biologicals IFNA10 Antibodies
Abcam antibodies for IFNA10
Browse Antibodies at Cloud-Clone Corp. 
Search ThermoFisher Antibodies for IFNA10
LSBio Antibodies in human, mouse, rat for IFNA10 

Assay Products for IFNA10: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IFNA10
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for IFNA10
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IFN: Interferons

4 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR015589 Interferon_alpha
 IPR000471 Interferon_alpha/beta/delta
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P01566

ProtoNet protein and cluster: P01566

1 Blocks protein domain: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFN10_HUMAN, P01566
Similarity: Belongs to the alpha/beta interferon family


IFNA10 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IFN10_HUMAN, P01566
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

     Genatlas biochemistry entry for IFNA10:
interferon type I,alpha 10,leukocyte

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005126cytokine receptor binding IEA--
     
IFNA10 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for IFNA10 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IFNA10

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IFNA10 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IFNA10 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA10
1 QIAGEN miScript miRNA Assays for microRNA that regulate IFNA10:
hsa-miR-4282
SwitchGear 3'UTR luciferase reporter plasmidIFNA10 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IFNA10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA10

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IFNA10
Sirion Biotech Customized adenovirus for overexpression of IFNA10

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IFNA10 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNA10 (NM_002171)
Sino Biological Human cDNA Clone for IFNA10
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA10
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA10
Sirion Biotech Customized lentivirus for stable overexpression of IFNA10 
                     Customized lentivirus expression plasmids for stable overexpression of IFNA10 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IFNA10
Search LifeMap BioReagents cell lines for IFNA10
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA10


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IFNA10 About   (see all 24)                                                                                              See pathways by source

SuperPathContained pathways About
1Toll-like receptor signaling pathway
Toll-like receptor signaling pathway0.93
Hepatitis B0.31
Toll-like receptor signaling pathway0.93
2Immune response IFN alpha/beta signaling pathway
Immune response IFN alpha/beta signaling pathway0.71
Interferon alpha/beta signaling0.45
Regulation of IFNA signaling0.71
3Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
RIG-I-like receptor signaling pathway0.52
5Influenza A
Influenza A0.34
Herpes simplex infection0.33
Measles0.34

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for IFNA10
    Immune response IFN alpha/beta signaling pathway
Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

2 R&D Systems Pathways for IFNA10
    NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA10
    Cytokine Network
Interferon Pathway
JAK-STAT Pathway
all-trans-Retinoic Acid Mediated Apoptosis

2 GeneGo (Thomson Reuters) Pathways for IFNA10
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
Immune response IFN alpha/beta signaling pathway

1 BioSystems Pathway for IFNA10
    Toll-like receptor signaling pathway


5/10        Reactome Pathways for IFNA10 (see all 10)
    Hemostasis
Regulation of IFNA signaling
Interferon alpha/beta signaling
Cytokine Signaling in Immune system
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways


5/15         Kegg Pathways  (Kegg details for IFNA10) (see all 15):
    Cytokine-cytokine receptor interaction
Regulation of autophagy
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway


IFNA10 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA10

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for IFNA10 (ENSP000003695664) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IFNAR1ENSP000002701394STRING: ENSP00000270139
IFNAR2ENSP000003439574STRING: ENSP00000343957
IFNGR1ENSP000003567134STRING: ENSP00000356713
IFNGR2ENSP000002902194STRING: ENSP00000290219
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006952defense response ----
GO:0007596blood coagulation TAS--
GO:0019221cytokine-mediated signaling pathway TAS--
GO:0045087innate immune response TAS--
GO:0051607defense response to virus IEA--

IFNA10 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNA10 (IFN10)

Search CenterWatch for drugs/clinical trials and news about IFNA10 / IFN10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNA10 gene: 
NM_002171.2  

Unigene Cluster for IFNA10:

Interferon, alpha 10
Hs.282275
Unigene Representative Sequence: NM_002171
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000357374(uc003zoq.1)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA10
1 QIAGEN miScript miRNA Assays for microRNA that regulate IFNA10:
hsa-miR-4282
SwitchGear 3'UTR luciferase reporter plasmidIFNA10 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IFNA10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA10
Clone
Products:
     
OriGene clones in human, mouse for IFNA10 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IFNA10 (NM_002171)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA10
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA10
Sirion Biotech Customized lentivirus for stable overexpression of IFNA10 
                     Customized lentivirus expression plasmids for stable overexpression of IFNA10 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for IFNA10
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IFNA10
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA10
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA10

Additional mRNA sequence: 

BC069409.1 BC103972.2 BC103973.1 V00551.1 

1 DOTS entry:

DT.121210182 

3 AceView cDNA sequences:

BC069409 V00551 NM_002171 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNA10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IFNA10 Expression
About this image


See IFNA10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA10

SOURCE GeneReport for Unigene cluster: Hs.282275
    SABiosciences Custom PCR Arrays for IFNA10
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for IFNA10
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IFNA10
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA10
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA10
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA10

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for IFNA10 (if available)
TreeFam Gene Tree for IFNA10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IFNA10 gene
IFNA72  IFNA22  IFNA42  IFNE2  IFNA142  IFNA52  IFNK2  IFNA12  
IFNA212  IFNA172  IFNA62  IFNB12  IFNA132  IFNW12  IFNA162  IFNA82  
18/19 SIMAP similar genes for IFNA10 using alignment to 1 protein entry:     IFN10_HUMAN(see all similar genes):
IFNA17    IFNA4    IFNA7    IFNA21    IFNA14    IFNA5
IFNA16    IFNA    IFNA2    IFNA6    IFNA8    IFN-2
IFNA1    IFNA13    IFNA2B    IFNW1    IFNB1    IFNE

IFNA10 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/158 SNPs in IFNA10 are shown (see all 158)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1909437581,2
--21205688(+) CCCCAC/TATGAC 1 -- ds50010--------
rs283681541,2
C,F--21205708(-) AAAGGA/CCGCAA 1 -- ds50012Minor allele frequency- C:0.06WA NA 238
rs1427499761,2
--21205830(+) TATCTC/GTGCTT 1 -- ds50010--------
rs283681521,2
C--21205943(-) AACAAC/TAATAA 1 -- ds50010--------
rs2001509351,2
C--21205966(+) CCTGA-/CAAAAA 1 -- ds50010--------
rs3726821381,2
C--21205980(+) AAGATA/C/GAAGAG 1 -- ds50010--------
rs283681511,2
C,F--21206081(-) TCATAA/CTTTTA 1 -- ds50012Minor allele frequency- C:0.06WA NA 238
rs1391259131,2
--21206093(+) AGGTAA/TCATAA 1 -- ds50010--------
rs1834665031,2
--21206155(+) CTTAAA/GGAATA 1 -- ds50010--------
rs283681501,2
C--21206174(-) AAAATA/TTCTTG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for IFNA10 (21206180 - 21207142 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for IFNA10:    About this table     
Variant IDTypeSubtypePubMed ID
esv2738274CNV Deletion23290073
dgv1305e201CNV Deletion23290073
esv2738277CNV Deletion23290073
nsv516132CNV Loss19592680
nsv892735CNV Loss21882294
esv6326CNV Loss19470904
nsv892724CNV Gain21882294
nsv892734CNV Gain21882294
nsv8425CNV Gain+Loss18304495


Human Gene Mutation Database (HGMD): IFNA10
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IFNA10
DNA2.0 Custom Variant and Variant Library Synthesis for IFNA10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147577    OMIM disorders: --

20 diseases for IFNA10:    About MalaCards
pulmonary sarcoidosis    hepatitis d    cortical blindness    dengue hemorrhagic fever
hemorrhagic fever    measles    hiv/aids    autoimmune thyroiditis
renal cell carcinoma    sarcoidosis    blindness    dementia
hepatitis c    cystic fibrosis    influenza    hepatitis b
hepatitis    thyroiditis    melanoma    tuberculosis

1 disease from the University of Copenhagen DISEASES database for IFNA10:
Cortical blindness

IFNA10 for disorders           About GeneDecksing

2 Novoseek inferred disease relationships for IFNA10 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
metastatic renal cell carcinoma 76.9 4 2144747 (1), 2222899 (1), 2250479 (1), 1746062 (1)
dementia 26.1 1 1746062 (1)

Genetic Association Database (GAD): IFNA10
Human Genome Epidemiology (HuGE) Navigator: IFNA10 (5 documents)

Export disorders for IFNA10 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IFNA10 gene, integrated from 9 sources (see all 70):
(articles sorted by number of sources associating them with IFNA10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
  2. Cystic fibrosis conductance regulator, tumor necrosis factor, interferon alpha-10, interferon alpha-17, and interferon gamma genotyp ing as potential risk markers in pulmonary sarcoidosis pathogenesis in Greek pa tients. (PubMed id 20722470)1, 4 Makrythanasis P....Kanavakis E. (2010)
  3. Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (2010)
  4. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (1998)
  7. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
  8. Identification of a functional allele of a human interferon-alpha gene previously characterized as a pseudogene. (PubMed id 2526839)1, 2 Bartholomew C. and Windass J.D. (1989)
  9. The structure of eight distinct cloned human leukocyte interferon cDNAs. (PubMed id 6163083)1, 2 Goeddel D.V.... Gray P.W. (1981)
  10. Inhibitory effects of human immunodeficiency virus gp1 20 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cel ls. (PubMed id 22814248)1 Fang M....Yao H. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3446 HGNC: 5418 AceView: IFNA10 Ensembl:ENSG00000186803 euGenes: HUgn3446
ECgene: IFNA10 Kegg: 3446 H-InvDB: IFNA10

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IFNA10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IFNA10 gene:
Search GeneIP for patents involving IFNA10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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