IFNA10 Gene
protein-coding GIFtS: 54
GCID: GC09M021245
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interferon, alpha 10
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Aliases for IFNA10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Interferon, Alpha 101 2 | | LeIF C2 3 | | IFN-AlphaC1 | | IFN-Alpha-101 | | Interferon Alpha-6L2 3 | | Interferon Alpha-102 | | Interferon Alpha-C2 3 | | |
Export aliases for IFNA10 gene to outside databasesPrevious GC identifers: GC09M021533 GC09M021407 GC09M021196 GC09M021215 GC09M021225 GC09M021175 GC09M021232 GC09M021235 GC09M021238 GC09M021242 |
Summaries for IFNA10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: IFN10_HUMAN, P01566Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase Gene Wiki entry for IFNA10
|
Genomic Views for IFNA10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IFNA10 gene promoter: Egr-3 Egr-2 IRF-7A Egr-4 Other transcription factors
Search SABiosciences Chromatin IP Primers for IFNA10
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA10 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22IFNA10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M021245: view genomic region
(about GC identifiers)
Start:
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21,206,180 bp from pter |
End:
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21,207,142 bp from pter |
Size:
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963 bases |
Orientation:
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minus strand |
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Proteins for IFNA10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: IFN10_HUMAN, P01566 (See
protein sequence)Recommended Name: Interferon alpha-10 precursor Size: 189 amino acids; 21835 Da
Subcellular location: Secreted
Secondary accessions: Q5VV13Explore the universe of human proteins at neXtProt for IFNA10: NX_P01566
IFNA10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002162.1 ENSEMBL proteins: ENSP00000369566 Reactome Protein details: P01566 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005615 | extracellular space |
IEA | -- |
IFNA10 for ontologies About GeneDecksing
IFNA10 Antibody Products: Assay Products for IFNA10: |
Protein
Domains / Families for IFNA10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFNA10 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P01566ProtoNet protein and cluster: P01566 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFN10_HUMAN, P01566Similarity: Belongs to the alpha/beta interferon family |
Function for IFNA10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: IFN10_HUMAN, P01566Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of twoenzymes: a protein kinase and an oligoadenylate synthetase Genatlas biochemistry entry for IFNA10:interferon type I,alpha 10,leukocyte
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA10 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA10 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNA10 (NM_002171) | |  | Sino Biological Human cDNA Clone for IFNA10 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA10  |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- | | GO:0005126 | cytokine receptor binding |
IEA | -- |
IFNA10 for ontologies About GeneDecksing
|
Pathways & Interactions for IFNA10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of IFNA signaling | | | 2 | Toll-like receptor signaling pathway | | | 3 | Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway | | | 4 | Cytokine Signaling in Immune system | | | 5 | Immune System | |
Pathway sources See GeneCards unified pathways Show all pathways
2 EMD Millipore Pathways for IFNA10 1 R&D Systems Pathway for IFNA10 4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA10 2 GeneGo (Thomson Reuters) Pathways for IFNA10 1 BioSystems Pathway for IFNA10 
5/11
Reactome Pathways for IFNA10 (see all 11)
5/12
Kegg Pathways (Kegg details for IFNA10) (see all 12):
IFNA10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IFNA10
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
 4 Interacting proteins for IFNA10 (ENSP000003695664) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
IFNA10 for ontologies About GeneDecksing
|
Drugs & Compounds for IFNA10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for IFNA10 Search CenterWatch for drugs/clinical trials and news about IFNA10 / IFN10 
|
Transcripts for IFNA10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for IFNA10 gene: NM_002171.1 Unigene Cluster for IFNA10: Interferon, alpha 10 Hs.282275 Unigene Representative Sequence: NM_0021711 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000357374(uc003zoq.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA10 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA10 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IFNA10 (NM_002171) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IFNA10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA10  |
Additional cDNA sequence: BC069409.1 BC103972.2 BC103973.1 V00551.1 1 DOTS entry: DT.121210182 3 AceView cDNA sequences: BC069409 NM_002171 V00551 GeneLoc Exon Structure
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Expression for IFNA10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IFNA10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See IFNA10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IFNA10
SOURCE GeneReport for Unigene cluster: Hs.282275 SABiosciences Custom PCR Arrays for IFNA10
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA10 Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IFNA10 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA10 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA10 |
Orthologs for IFNA10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IFNA10 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for IFNA10 (if available) TreeFam Gene Tree for IFNA10 (if available)  |
Paralogs for IFNA10 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for IFNA10 gene
- IFNA72 IFNA22 IFNE2 IFNA42 IFNA142 IFNK2 IFNA52 IFNA12
- IFNA212 IFNA172 IFNA62 IFNB12 IFNA132 IFNW12 IFNA162 IFNA82
18/19 SIMAP similar genes for IFNA10 using alignment to 1 protein entry: IFN10_HUMAN(see all similar genes):IFNA17 IFNA4 IFNA7 IFNA21 IFNA14 IFNA5 IFNA16 IFNA IFNA2 IFNA6 IFNA8 IFN-2 IFNA1 IFNA13 IFNA2B IFNW1 IFNB1 IFNE
IFNA10 for paralogs About GeneDecksing
|
Genomic Variants for IFNA10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 9 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for IFNA10 (21206180 - 21207142 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for IFNA10 4 CNVs: 33078 62888 52772 31466 Human Gene Mutation Database (HGMD): IFNA10
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA10 |
|
Disorders
/ Diseases for IFNA10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFNA10 for disorders About GeneDecksing
OMIM gene information: 147577
OMIM disorders: --
20/21 diseases for IFNA10 (see all 21): About MalaCardsdengue hemorrhagic fever hemorrhagic fever renal cell carcinoma cortical blindness hepatitis d pulmonary sarcoidosis sarcoidosis cystic fibrosis autoimmune thyroiditis hepatitis c dementia hepatitis b measles hepatitis fibrosis blindness influenza thyroiditis melanoma carcinoma
1 disease from the University of Copenhagen DISEASES database for IFNA10:Cortical blindness 2 Novoseek disease relationships for IFNA10 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| metastatic renal cell carcinoma |
76.9 |
4 |
2144747 (1), 2222899 (1), 2250479 (1), 1746062 (1) |
| dementia |
26.1 |
1 |
1746062 (1) |
Human Genome Epidemiology (HuGE) Navigator: IFNA10 (5 documents) Export disorders for IFNA10 gene to outside databases
|
Publications for IFNA10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IFNA10 gene, integrated from 9 sources (see all 69): (articles sorted by number of sources associating them with IFNA10) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)1, 2 Nyman T.A.... Kalkkinen N. (1998)
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3 Olopade O.I....Diaz M.O. (1992)
- Identification of a functional allele of a human interferon-alpha gene previously characterized as a pseudogene. (PubMed id 2526839)1, 2 Bartholomew C. and Windass J.D. (1989)
- The structure of eight distinct cloned human leukocyte interferon cDNAs. (PubMed id 6163083)1, 2 Goeddel D.V.... Gray P.W. (1981)
- Inhibitory effects of human immunodeficiency virus gp1 20 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cel ls. (PubMed id 22814248)1 Fang M....Yao H. (2012)
- HIV-1 Gag-virus-like particles inhibit HIV-1 replicati on in dendritic cells and T cells through IFN-a-dependent upregulation of APOBEC 3G and 3F. (PubMed id 22739040)1 Chang M.O....Takaku H. (2012)
- Role of retroviral restriction factors in the interfer on-a-mediated suppression of HIV-1 in vivo. (PubMed id 22315404)1 Pillai S.K....Wong J.K. (2012)
- Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics. (PubMed id 20096141)1 Albin J.S. and Harris R.S. (2010)
- Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1 Mosbruger T.L....Thio C.L. (2010)
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External Searches for IFNA10 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IFNA10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFNA10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNA10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for IFNA10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IFNA10 gene: Search GeneIP for patents involving IFNA10
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for IFNA10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for IFNA10 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNA10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IFNA10 | | OriGene Protein Over-expression Lysate for IFNA10 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for IFNA10 | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IFNA10 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for IFNA10 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for IFNA10 | | OriGene Custom Protein Services for IFNA10 | | OriGene Custom Immunoassay Development | | |
| |  |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IFNA10 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA10 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA10 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA10 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA10 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA10 |
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 | | | | |  |  |  | | | Search ThermoFisher Antibodies for IFNA10 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA10 |
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