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Aliases for IFNA10 Gene

Aliases for IFNA10 Gene

  • Interferon, Alpha 10 2 3 5
  • Interferon Alpha-6L 3 4
  • Interferon Alpha-C 3 4
  • IFN-Alpha-10 3 4
  • LeIF C 3 4
  • IFN-AlphaC 3

External Ids for IFNA10 Gene

Previous GeneCards Identifiers for IFNA10 Gene

  • GC09M021533
  • GC09M021407
  • GC09M021196
  • GC09M021215
  • GC09M021225
  • GC09M021175
  • GC09M021232
  • GC09M021235
  • GC09M021238
  • GC09M021242
  • GC09M021245
  • GC09M021248
  • GC09M021252
  • GC09M021257
  • GC09M021262

Summaries for IFNA10 Gene

Entrez Gene Summary for IFNA10 Gene

  • This gene encodes a protein that belongs to the type I interferon family of proteins, and is located in a cluster of alpha interferon genes on chromosome 9. Interferons are small regulatory molecules that function in cell signaling in response to viruses and other pathogens or tumor cells. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Aug 2013]

GeneCards Summary for IFNA10 Gene

IFNA10 (Interferon, Alpha 10) is a Protein Coding gene. Diseases associated with IFNA10 include visual cortex disease and visual pathway disease. Among its related pathways are Allograft rejection and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA10 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA10 Gene

Genomics for IFNA10 Gene

Regulatory Elements for IFNA10 Gene


Genomic Location for IFNA10 Gene

Chromosome:
9
Start:
21,206,181 bp from pter
End:
21,207,143 bp from pter
Size:
963 bases
Orientation:
Minus strand

Genomic View for IFNA10 Gene

Genes around IFNA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA10 Gene

Proteins for IFNA10 Gene

  • Protein details for IFNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01566-IFN10_HUMAN
    Recommended name:
    Interferon alpha-10
    Protein Accession:
    P01566
    Secondary Accessions:
    • Q5VV13

    Protein attributes for IFNA10 Gene

    Size:
    189 amino acids
    Molecular mass:
    21835 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA10 Gene

Proteomics data for IFNA10 Gene at MOPED

Post-translational modifications for IFNA10 Gene

No Post-translational modifications

Other Protein References for IFNA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA10 Gene

Domains & Families for IFNA10 Gene

Gene Families for IFNA10 Gene

Suggested Antigen Peptide Sequences for IFNA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01566

UniProtKB/Swiss-Prot:

IFN10_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA10: view

Function for IFNA10 Gene

Molecular function for IFNA10 Gene

GENATLAS Biochemistry:
interferon type I,alpha 10,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
genes like me logo Genes that share phenotypes with IFNA10: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA10 Gene

Localization for IFNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA10 Gene COMPARTMENTS Subcellular localization image for IFNA10 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for IFNA10 Gene

Pathways & Interactions for IFNA10 Gene

genes like me logo Genes that share pathways with IFNA10: view

Gene Ontology (GO) - Biological Process for IFNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
GO:0007596 blood coagulation TAS --
GO:0019221 cytokine-mediated signaling pathway IBA,TAS --
genes like me logo Genes that share ontologies with IFNA10: view

No data available for SIGNOR curated interactions for IFNA10 Gene

Drugs & Compounds for IFNA10 Gene

No Compound Related Data Available

Transcripts for IFNA10 Gene

mRNA/cDNA for IFNA10 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA10 Gene

No ASD Table

Relevant External Links for IFNA10 Gene

GeneLoc Exon Structure for
IFNA10
ECgene alternative splicing isoforms for
IFNA10

Expression for IFNA10 Gene

mRNA expression in normal human tissues for IFNA10 Gene

Protein differential expression in normal tissues from HIPED for IFNA10 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFNA10 Gene



SOURCE GeneReport for Unigene cluster for IFNA10 Gene Hs.282275

genes like me logo Genes that share expression patterns with IFNA10: view

Protein tissue co-expression partners for IFNA10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFNA10 Gene

Orthologs for IFNA10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA4 35
  • 96.3 (n)
  • 93.65 (a)
-- 36
  • 96 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
IFNAA 36
  • 62 (a)
ManyToMany
IFNAG 36
  • 63 (a)
ManyToMany
IFNAG 36
  • 64 (a)
ManyToMany
IFNAH 36
  • 63 (a)
ManyToMany
INFAF 36
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 36
  • 62 (a)
ManyToMany
Gm13280 36
  • 60 (a)
ManyToMany
Ifna1 36
  • 61 (a)
ManyToMany
Ifna11 36
  • 57 (a)
ManyToMany
Ifna12 36
  • 61 (a)
ManyToMany
Ifna13 36
  • 61 (a)
ManyToMany
Ifna14 36
  • 58 (a)
ManyToMany
Ifna2 36
  • 57 (a)
ManyToMany
Ifna4 36
  • 56 (a)
ManyToMany
Ifna5 36
  • 61 (a)
ManyToMany
Ifna6 36
  • 61 (a)
ManyToMany
Ifna7 36
  • 59 (a)
ManyToMany
Ifna9 36
  • 59 (a)
ManyToMany
Ifnab 36
  • 59 (a)
ManyToMany
Species with no ortholog for IFNA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA10 Gene

ENSEMBL:
Gene Tree for IFNA10 (if available)
TreeFam:
Gene Tree for IFNA10 (if available)

Paralogs for IFNA10 Gene

(19) SIMAP similar genes for IFNA10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA10: view

Variants for IFNA10 Gene

Sequence variations from dbSNP and Humsavar for IFNA10 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2230853 - 21,206,973(-) CCTGG(C/G)ACAAA reference, missense
rs1062570 -- 21,206,893(-) ATGGC(A/C)ACCAG reference, missense
rs1062578 -- 21,206,516(-) GTTCA(A/T)CATGG utr-variant-3-prime
rs1062581 -- 21,206,489(-) CTAAT(A/G)CATTA utr-variant-3-prime
rs1062582 -- 21,206,485(-) TACAT(C/T)ATCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IFNA10 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294
esv2738274 CNV Deletion 23290073
dgv1305e201 CNV Deletion 23290073
nsv516132 CNV Loss 19592680
nsv8425 CNV Gain+Loss 18304495
esv6326 CNV Loss 19470904
esv2738277 CNV Deletion 23290073

Variation tolerance for IFNA10 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA10 Gene

HapMap Linkage Disequilibrium report
IFNA10
Human Gene Mutation Database (HGMD)
IFNA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA10 Gene

Disorders for IFNA10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IFNA10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
visual cortex disease
  • visual cortex dysfunction
visual pathway disease
  • disorder of visual pathways
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IFNA10

Genetic Association Database (GAD)
IFNA10
Human Genome Epidemiology (HuGE) Navigator
IFNA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA10
genes like me logo Genes that share disorders with IFNA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA10 Gene

Publications for IFNA10 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 48 67
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  3. HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms. (PMID: 25972534) Reszka-Blanco N.J. … Su L. (J. Virol. 2015) 3
  4. Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients. (PMID: 26000985) Xiao C.X. … Guleng B. (Sci Rep 2015) 3
  5. Evidence for a different susceptibility of primate lentiviruses to type I interferons. (PMID: 23255800) Cordeil S. … Cimarelli A. (J. Virol. 2013) 3

Products for IFNA10 Gene

Sources for IFNA10 Gene

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