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Aliases for IFNA10 Gene

Aliases for IFNA10 Gene

  • Interferon Alpha 10 2 3 5
  • Interferon Alpha-6L 3 4
  • Interferon Alpha-C 3 4
  • IFN-Alpha-10 3 4
  • LeIF C 3 4
  • Interferon Alpha-10 3
  • IFN-AlphaC 3

External Ids for IFNA10 Gene

Previous GeneCards Identifiers for IFNA10 Gene

  • GC09M021533
  • GC09M021407
  • GC09M021196
  • GC09M021215
  • GC09M021225
  • GC09M021175
  • GC09M021232
  • GC09M021235
  • GC09M021238
  • GC09M021242
  • GC09M021245
  • GC09M021248
  • GC09M021252
  • GC09M021257
  • GC09M021262
  • GC09M021266
  • GC09M021272

Summaries for IFNA10 Gene

Entrez Gene Summary for IFNA10 Gene

  • This gene encodes a protein that belongs to the type I interferon family of proteins, and is located in a cluster of alpha interferon genes on chromosome 9. Interferons are small regulatory molecules that function in cell signaling in response to viruses and other pathogens or tumor cells. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Aug 2013]

GeneCards Summary for IFNA10 Gene

IFNA10 (Interferon Alpha 10) is a Protein Coding gene. Diseases associated with IFNA10 include Visual Cortex Disease and Visual Pathway Disease. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA17.

UniProtKB/Swiss-Prot for IFNA10 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA10 Gene

Genomics for IFNA10 Gene

Regulatory Elements for IFNA10 Gene


Genomic Location for IFNA10 Gene

Chromosome:
9
Start:
21,206,181 bp from pter
End:
21,207,143 bp from pter
Size:
963 bases
Orientation:
Minus strand

Genomic View for IFNA10 Gene

Genes around IFNA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA10 Gene

Proteins for IFNA10 Gene

  • Protein details for IFNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01566-IFN10_HUMAN
    Recommended name:
    Interferon alpha-10
    Protein Accession:
    P01566
    Secondary Accessions:
    • Q5VV13

    Protein attributes for IFNA10 Gene

    Size:
    189 amino acids
    Molecular mass:
    21835 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA10 Gene

Post-translational modifications for IFNA10 Gene

No Post-translational modifications

Other Protein References for IFNA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA10 Gene

Domains & Families for IFNA10 Gene

Gene Families for IFNA10 Gene

Suggested Antigen Peptide Sequences for IFNA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01566

UniProtKB/Swiss-Prot:

IFN10_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA10: view

Function for IFNA10 Gene

Molecular function for IFNA10 Gene

GENATLAS Biochemistry:
interferon type I,alpha 10,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA10: view
genes like me logo Genes that share phenotypes with IFNA10: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA10 Gene

Localization for IFNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA10 gene
Compartment Confidence
extracellular 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IFNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA10: view

Pathways & Interactions for IFNA10 Gene

genes like me logo Genes that share pathways with IFNA10: view

Gene Ontology (GO) - Biological Process for IFNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA10: view

No data available for SIGNOR curated interactions for IFNA10 Gene

Transcripts for IFNA10 Gene

mRNA/cDNA for IFNA10 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA10 Gene

No ASD Table

Relevant External Links for IFNA10 Gene

GeneLoc Exon Structure for
IFNA10
ECgene alternative splicing isoforms for
IFNA10

Expression for IFNA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA10 Gene

Protein differential expression in normal tissues from HIPED for IFNA10 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFNA10 Gene



Protein tissue co-expression partners for IFNA10 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNA10 Gene:

IFNA10

SOURCE GeneReport for Unigene cluster for IFNA10 Gene:

Hs.282275
genes like me logo Genes that share expression patterns with IFNA10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IFNA10 Gene

Orthologs for IFNA10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA4 34
  • 96.3 (n)
-- 35
  • 96 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 64 (a)
ManyToMany
-- 35
  • 63 (a)
ManyToMany
-- 35
  • 63 (a)
ManyToMany
-- 35
  • 63 (a)
ManyToMany
IFNAG 35 35
  • 63 (a)
ManyToMany
IFNAH 35
  • 63 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
IFNAA 35
  • 62 (a)
ManyToMany
INFAF 35
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 35
  • 62 (a)
ManyToMany
Ifna1 35
  • 61 (a)
ManyToMany
Ifna12 35
  • 61 (a)
ManyToMany
Ifna13 35
  • 61 (a)
ManyToMany
Ifna5 35
  • 61 (a)
ManyToMany
Ifna6 35
  • 61 (a)
ManyToMany
Gm13280 35
  • 60 (a)
ManyToMany
Ifna7 35
  • 59 (a)
ManyToMany
Ifna9 35
  • 59 (a)
ManyToMany
Ifnab 35
  • 59 (a)
ManyToMany
Ifna14 35
  • 58 (a)
ManyToMany
Ifna11 35
  • 57 (a)
ManyToMany
Ifna2 35
  • 57 (a)
ManyToMany
Ifna4 35
  • 56 (a)
ManyToMany
Species where no ortholog for IFNA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA10 Gene

ENSEMBL:
Gene Tree for IFNA10 (if available)
TreeFam:
Gene Tree for IFNA10 (if available)

Paralogs for IFNA10 Gene

(19) SIMAP similar genes for IFNA10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA10: view

Variants for IFNA10 Gene

Sequence variations from dbSNP and Humsavar for IFNA10 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10113875 -- 21,207,001(+) ATTAC(A/C/G)CAGGC reference, missense
rs10113876 -- 21,207,006(+) CCAGG(C/G)TGTGG reference, missense
rs10113987 -- 21,207,449(+) AACTA(C/G)AAAGT upstream-variant-2KB
rs10117060 -- 21,207,032(+) CAGCC(A/C/T)AGAGA reference, synonymous-codon
rs10119910 -- 21,207,038(+) AGAGA(A/G/T)CAGAT reference, synonymous-codon, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for IFNA10 Gene

Variant ID Type Subtype PubMed ID
nsv968599 CNV duplication 23825009
nsv8425 CNV gain+loss 18304495
nsv613756 CNV loss 21841781
nsv613755 CNV loss 21841781
nsv516132 CNV loss 19592680
nsv1118060 CNV deletion 24896259
nsv1035128 CNV gain 25217958
nsv1033177 CNV gain 25217958
nsv1021574 CNV gain 25217958
esv6326 CNV loss 19470904
esv3619954 CNV loss 21293372
esv3619953 CNV gain 21293372
esv3619952 CNV loss 21293372
esv3573167 CNV loss 25503493
esv2764150 CNV gain+loss 21179565
esv2738277 CNV deletion 23290073
esv2738274 CNV deletion 23290073
dgv7474n100 CNV loss 25217958
dgv1253e201 CNV deletion 23290073

Variation tolerance for IFNA10 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA10 Gene

Human Gene Mutation Database (HGMD)
IFNA10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA10 Gene

Disorders for IFNA10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IFNA10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
visual cortex disease
  • visual cortex dysfunction
visual pathway disease
  • disorder of visual pathways
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IFNA10

Genetic Association Database (GAD)
IFNA10
Human Genome Epidemiology (HuGE) Navigator
IFNA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA10
genes like me logo Genes that share disorders with IFNA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA10 Gene

Publications for IFNA10 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 46 64
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 64
  4. Cystic fibrosis conductance regulator, tumor necrosis factor, interferon alpha-10, interferon alpha-17, and interferon gamma genotyping as potential risk markers in pulmonary sarcoidosis pathogenesis in Greek patients. (PMID: 20722470) Makrythanasis P. … Kanavakis E. (Genet Test Mol Biomarkers 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for IFNA10 Gene

Sources for IFNA10 Gene

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