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Aliases for IFNA10 Gene

Aliases for IFNA10 Gene

  • Interferon, Alpha 10 2 3
  • Interferon Alpha-6L 3 4
  • Interferon Alpha-C 3 4
  • IFN-Alpha-10 3 4
  • LeIF C 3 4
  • Interferon Alpha-10 3
  • IFN-AlphaC 3

External Ids for IFNA10 Gene

Summaries for IFNA10 Gene

Entrez Gene Summary for IFNA10 Gene

  • This gene encodes a protein that belongs to the type I interferon family of proteins, and is located in a cluster of alpha interferon genes on chromosome 9. Interferons are small regulatory molecules that function in cell signaling in response to viruses and other pathogens or tumor cells. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Aug 2013]

GeneCards Summary for IFNA10 Gene

IFNA10 (Interferon, Alpha 10) is a Protein Coding gene. Diseases associated with IFNA10 include cortical blindness and pulmonary sarcoidosis. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and cytokine receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA10 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA10 Gene

Genomics for IFNA10 Gene

Genomic Location for IFNA10 Gene

Start:
21,206,181 bp from pter
End:
21,207,143 bp from pter
Size:
963 bases
Orientation:
Minus strand

Genomic View for IFNA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA10 Gene

Regulatory Elements for IFNA10 Gene

Proteins for IFNA10 Gene

  • Protein details for IFNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01566-IFN10_HUMAN
    Recommended name:
    Interferon alpha-10
    Protein Accession:
    P01566
    Secondary Accessions:
    • Q5VV13

    Protein attributes for IFNA10 Gene

    Size:
    189 amino acids
    Molecular mass:
    21835 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA10 Gene

Proteomics data for IFNA10 Gene at MOPED

Post-translational modifications for IFNA10 Gene

No Post-translational modifications

Other Protein References for IFNA10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA10 Gene

Domains for IFNA10 Gene

Gene Families for IFNA10 Gene

HGNC:
  • IFN :Interferons

UniProtKB/Swiss-Prot:

IFN10_HUMAN
Family:
  • Belongs to the alpha/beta interferon family.:
    • P01566
genes like me logo Genes that share domains with IFNA10: view

Function for IFNA10 Gene

Molecular function for IFNA10 Gene

GENATLAS Biochemistry: interferon type I,alpha 10,leukocyte
UniProtKB/Swiss-Prot Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Ontology (GO) - Molecular Function for IFNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA10: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IFNA10 Gene

Localization for IFNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA10 Gene COMPARTMENTS Subcellular localization image for IFNA10 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IFNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA10: view

Pathways for IFNA10 Gene

genes like me logo Genes that share pathways with IFNA10: view

Gene Ontology (GO) - Biological Process for IFNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA10: view

Transcripts for IFNA10 Gene

mRNA/cDNA for IFNA10 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA10 Gene

No ASD Table

Relevant External Links for IFNA10 Gene

GeneLoc Exon Structure for
IFNA10
ECgene alternative splicing isoforms for
IFNA10

Expression for IFNA10 Gene

mRNA expression in normal human tissues for IFNA10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IFNA10 Gene

SOURCE GeneReport for Unigene cluster for IFNA10 Gene Hs.282275

genes like me logo Genes that share expressions with IFNA10: view

Orthologs for IFNA10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 96 (a)
OneToMany
IFNA4 36
  • 96.3 (n)
  • 93.65 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 63 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
-- 37
  • 64 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
IFNAA 37
  • 62 (a)
ManyToMany
IFNAG 37
  • 63 (a)
ManyToMany
IFNAG 37
  • 64 (a)
ManyToMany
IFNAH 37
  • 63 (a)
ManyToMany
INFAF 37
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12597 37
  • 62 (a)
ManyToMany
Gm13280 37
  • 60 (a)
ManyToMany
Ifna1 37
  • 61 (a)
ManyToMany
Ifna11 37
  • 57 (a)
ManyToMany
Ifna12 37
  • 61 (a)
ManyToMany
Ifna13 37
  • 61 (a)
ManyToMany
Ifna14 37
  • 58 (a)
ManyToMany
Ifna2 37
  • 57 (a)
ManyToMany
Ifna4 37
  • 56 (a)
ManyToMany
Ifna5 37
  • 61 (a)
ManyToMany
Ifna6 37
  • 61 (a)
ManyToMany
Ifna7 37
  • 59 (a)
ManyToMany
Ifna9 37
  • 59 (a)
ManyToMany
Ifnab 37
  • 59 (a)
ManyToMany
Species with no ortholog for IFNA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA10 Gene

ENSEMBL:
Gene Tree for IFNA10 (if available)
TreeFam:
Gene Tree for IFNA10 (if available)

Paralogs for IFNA10 Gene

Selected SIMAP similar genes for IFNA10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA10: view

Variants for IFNA10 Gene

Sequence variations from dbSNP and Humsavar for IFNA10 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1062570 -- 21,206,893(-) ATGGC(A/C)ACCAG reference, missense
rs1062578 -- 21,206,516(-) GTTCA(A/T)CATGG utr-variant-3-prime
rs1062581 -- 21,206,489(-) CTAAT(A/G)CATTA utr-variant-3-prime
rs1062582 -- 21,206,485(-) TACAT(C/T)ATCTC utr-variant-3-prime
rs1062586 -- 21,206,385(-) AGAAG(C/T)GTCGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IFNA10 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294
esv2738274 CNV Deletion 23290073
dgv1305e201 CNV Deletion 23290073
nsv516132 CNV Loss 19592680
nsv8425 CNV Gain+Loss 18304495
esv6326 CNV Loss 19470904
esv2738277 CNV Deletion 23290073

Relevant External Links for IFNA10 Gene

HapMap Linkage Disequilibrium report
IFNA10
Human Gene Mutation Database (HGMD)
IFNA10

Disorders for IFNA10 Gene

(1) University of Copenhagen DISEASES for IFNA10 Gene

(2) Novoseek inferred disease relationships for IFNA10 Gene

Disease -log(P) Hits PubMed IDs
metastatic renal cell carcinoma 76.9 4
dementia 26.1 1

Relevant External Links for IFNA10

Genetic Association Database (GAD)
IFNA10
Human Genome Epidemiology (HuGE) Navigator
IFNA10
genes like me logo Genes that share disorders with IFNA10: view

No data available for UniProtKB/Swiss-Prot for IFNA10 Gene

Publications for IFNA10 Gene

  1. The structure of eight distinct cloned human leukocyte interferon cDNAs. (PMID: 6163083) Goeddel D.V. … Gray P.W. (Nature 1981) 3 4
  2. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PMID: 9425112) Nyman T.A. … Kalkkinen N. (Biochem. J. 1998) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 49
  5. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 49

Products for IFNA10 Gene

Sources for IFNA10 Gene

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