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IFNA1 Gene

protein-coding   GIFtS: 60

GC09P021430
interferon, alpha 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
IFL 1, 2
IFN 1, 2
IFN-ALPHA 1, 2
IFNA13 1, 2
IFNA@ 1, 2, 5
MGC138207 2
MGC138505 2
MGC138507 2
OTTHUMP00000045110 2
Descriptions
IFN-alpha 1b 2
Interferon alpha-D 3
LeIF D 3
interferon alpha 1b 2
interferon, alpha 1 2
External Ids
HGNC: 54171
Entrez Gene: 34392
UniProtKB: P015623
Ensembl: ENSG000001979197
Search outside databases for aliases for IFNA1 gene

Previous GC identifers: GC09P021768 GC09P021641

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IFNA1:
Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma; MIM
147570) is produced by mitogen- or antigen-stimulated T lymphocytes.[supplied by OMIM]

UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the
production of two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA1 (Interferon%2C_alpha_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IFNA1 gene  

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P021430:     (about GC identifiers)

Start:
21,430,440 bp from pter
End:
21,431,315 bp from pter
Size:
876 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000009.10  NT_008413.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562 (See protein sequence)
Recommended Name: Interferon alpha-1/13 precursor  
Size: 189 amino acids; 21725 Da
Subcellular location: Secreted
Miscellaneous: Interferons alpha-1 and alpha-13 have identical protein sequences
Secondary accessions: Q14605 Q2M1L8 Q52LB8 Q5VYQ2 Q7M4Q1 Q8WZ68 Q9UMJ3

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_076918.1  

    ENSEMBL proteins: 
    ENSP00000276927 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for IFNA1  
    R&D Systems Recombinant & Natural Proteins for IFNA1 (IFN-alpha D, IFN-alpha 1, IFN)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Interferon alpha)
    Human Recombinant Proteins from Abnova (IFNA1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for IFNA1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for IFNA1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for IFNA1  (IFN-alpha)
    Antibodies from Abcam (Interferon alpha), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibodies for IFNA1

    Assays for IFNA1: 
    Invitrogen Assays for IFNA1
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR012351 4_helix_cytokine_core
     IPR015589 Interferon_alpha
     IPR000471 IInterferon_alpha/beta/delta


       GeneDecks  IFNA1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P01562

    ProtoNet protein and cluster: P01562

    1 Blocks protein family: IPB000471 Interferon alpha

    UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562
    Similarity: Belongs to the alpha/beta interferon family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (IFNA1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024013

                  Applied Biosystems Silencer® siRNAs for IFNA1

                  Sigma-Aldrich siRNA and siRNA Panels for IFNA1  
                         Sigma-Aldrich shRNA Panels and shRNA for IFNA1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for IFNA1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_024013
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_024013
                                     untagged cDNA clone in CMV expression vector: NM_024013 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_024013

    UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562
    Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the
    production of two enzymes: a protein kinase and an oligoadenylate synthetase

    Genatlas biochemistry entry for IFNA1:
    interferon type I,alpha 1,leukocyte
    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Millipore Pathways for IFNA1
     Immune response IFN alpha/beta signaling pathway
      TICAM1-specific signaling pathways

       GeneDecks  IFNA1 for the pathways selected above  
    About GeneDecksing

    5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for  IFNA1  (Your Favorite Gene powered by Ingenuity) (see all 9
     IL-12 Signaling and Production in Macrophages
     IL-15 Production
     Role of Cytokines in Mediating Communication between Immune Cells
     Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
     Dendritic Cell Maturation

       GeneDecks  IFNA1 for the pathways selected above  
    About GeneDecksing

    5/7 Kegg Pathways  (Kegg details for IFNA1) (see all 7 ):
     hsa04060 Cytokine-cytokine receptor interaction
     hsa04140 Regulation of autophagy
     hsa04612 Antigen processing and presentation
     hsa04620 Toll-like receptor signaling pathway
     hsa04630 Jak-STAT signaling pathway

       GeneDecks  IFNA1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  IFNA1 

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for IFNA1
    10/28 Novoseek chemical compound relationships for IFNA1 gene (see all 28 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    ifn-alpha 94.81 1908 16142050 (22), 15389589 (13), 15581417 (12), 11505050 (12) (see all 99)
    poly(i-c) 73.09 56 1330423 (2), 8444700 (2), 12519390 (2), 17108037 (2) (see all 39)
    neopterin 61.90 64 16273760 (4), 8136311 (3), 14573318 (3), 15153315 (3) (see all 33)
    resiquimod 61.09 12 12470615 (3), 19183807 (1), 18342575 (1), 14638493 (1) (see all 8)
    p113 61.07 5 7529187 (2), 8917387 (1), 8306959 (1), 8156998 (1)
    indoleamine 58.31 5 12466036 (1), 18776940 (1), 9712367 (1), 18950381 (1) (see all 5)
    mnda 54.06 7 7890814 (2), 11215814 (2), 14618084 (2)
    tyrosine 50.87 220 10803933 (6), 7532663 (5), 1385434 (5), 11682488 (4) (see all 99)
    loxoribine 50.46 2 17804388 (1), 17579574 (1), 17371961 (1)
    rantes 47.57 33 9491913 (3), 14679297 (2), 16940859 (2), 9247020 (1) (see all 29)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (IFNA1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024013

                  Sigma-Aldrich siRNA and siRNA Panels for IFNA1  
                         Sigma-Aldrich shRNA Panels and shRNA for IFNA1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_024013  

    REFSEQ mRNAs for IFNA1 gene: 

    NM_024013.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_024013  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_024013
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_024013
                                     untagged cDNA clone in CMV expression vector: NM_024013 

    Additional cDNA sequence: 

    BC074928.2 BC074929.2 BC112002.1 BC112300.1 BC112302.1 V00537.1 V00538.1 

    2 DOTS entries:

    DT.209454  DT.121155340 

    5 AceView cDNA sequences:

    BC074928 NM_024013 BC074929 V00537 V00538 

    highest scoring ESTs for IFNA1:

    BC074928 BC074929 BC112300 BC112302 J00210 V00537 V00538 NM_024013 BC112002 

    Unigene Cluster for IFNA1:

    Interferon, alpha 1
    Hs.37026
    Unigene Representative Sequence: NM_024013


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000276927  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    IFNA1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for IFNA1

    1 / 2 / 3

    5 probe-sets matching IFNA1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    1666_at2, 3 U95-A 2 1.00 0.81 1.00 1.00 J00210 0.20 1.00 0.72 1

    208375_at2, 3 U133-A 2 1.00 0.77 -- -- NM_024013 0.40 0.67 0.55 1

    208344_x_at2 U133-A 12 1.00 0.35 -- -- -- -- -- -- --

    208375_at2 U133Plus2 2 1.00 0.77 -- -- -- -- -- -- --

    208344_x_at2 U133Plus2 12 1.00 0.35 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.37026

    Expression variation in blood from EXPOLDB for IFNA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for IFNA1 gene from 3 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    IFNA131   -- interferon, alpha 13 99.12(n)
    98.41(a)
    742651  XM_001152509.1  XP_001152509.1 
    rat
    (Rattus norvegicus)
    Ifna51   -- interferon alpha family, gene 5 73.02(n)
    58.2(a)
    690894  XM_001076062.1  XP_001076062.1 
    mouse
    (Mus musculus)
    Ifna61   -- interferon alpha 6 76.54(n)
    64.55(a)
    15969  NM_206871.1  NP_996754.1 
    About this table        Species with no ortholog for IFNA1

    ENSEMBL Gene Tree for IFNA1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for IFNA1 gene
    IFNA131 2  IFNA212  IFNA22  IFNA72  IFNA172  IFNA42  IFNA62  IFNA142  
    IFNA162  IFNA102  IFNA82  IFNA52  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562
    Polymorphism: Two forms exist; alpha-1a (shown here) and alpha-1b


    10/43 NCBI SNPs in IFNA1 are shown (see all 43 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 18)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs13321901,2
    A,C,F,H,O21428684(-) TCCATC/TGTCTA 1 -- ng5117Minor allele frequency- N:0.00EU EA WA NA NS 1242
    --
    rs108115431,2
    A,C,F,H21429656(+) AATTTG/AATACA 1 -- ng518Minor allele frequency- A:0.29EA WA NS 426
    --
    rs17585671,2
    C,F,H21430535(+) GATGGT/CCCTGG 1 A/V mis110Minor allele frequency- C:0.12MN EU EA NS 722
    --
    rs109649951,2
    C,F21429456(+) ATTTGG/ATTCTG 1 -- ng515Minor allele frequency- A:0.04NS 190
    --
    rs10657531,2
    F,H21431079(+) TAACAT/CCTGGT 1 -- ut31 ese32Minor allele frequency- C:0.17MN EU 160
    --
    rs283837931,2
    C,F21430416(+) AAGGCA/GTTTGC 1 -- ng5110Minor allele frequency- G:0.03MN CSAM EA NS 532
    --
    rs126859041,2
    C,F21431310(+) TATATT/GTACTC 1 -- ut315Minor allele frequency- G:0.06NS 188
    --
    rs339650701,2
    C,F21430994(+) TTGTGC/GCTGGG 1 A/G mis15Minor allele frequency- G:0.13NS 188
    --
    rs283837961,2
    C,F21431116(+) TCATAC/TACCAG 1 -- ut31 ese35Minor allele frequency- T:0.08NS 188
    --
    rs18315831,2
    C,F21429076(+) tttatA/Ctacct 1 -- ng515Minor allele frequency- C:0.04NS 190
    About this table

    HapMap Linkage Disequilibrium images for IFNA1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 147660

    10/96 Novoseek disease relationships for IFNA1 gene (see all 96 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c chronic 95.14 1659 10846411 (5), 9751011 (4), 15313671 (4), 12639294 (4) (see all 99)
    hepatitis c 90.42 812 9136611 (5), 9348307 (4), 9363321 (4), 11068424 (4) (see all 99)
    myeloid leukemia chronic 85.41 292 8249110 (2), 9362160 (2), 11236254 (2), 11865642 (2) (see all 99)
    hepatitis b chronic 85.18 393 11983129 (5), 16171525 (4), 16118673 (4), 10462338 (4) (see all 99)
    virus infection 82.61 451 11983129 (5), 8895920 (4), 17516539 (4), 9269299 (3) (see all 99)
    hepatitis chronic 82.55 162 12768394 (3), 9731580 (3), 1688684 (2), 7521417 (2) (see all 99)
    metastatic renal cell carcinoma 82.42 106 15852669 (2), 8647158 (2), 12778059 (2), 19047813 (2) (see all 92)
    hepatitis chronic active 78.57 105 9136611 (4), 8021761 (3), 16394599 (2), 7564784 (2) (see all 81)
    cml chronic phase 78.33 35 11042556 (2), 12973833 (2), 12620292 (1), 11369652 (1) (see all 30)
    leukemia hairy cell 77.46 58 9830322 (3), 9001417 (3), 1851909 (2), 1697012 (1) (see all 53)
    About this table

    Genetic Association Database: IFNA1
    Human Genome Epidemiology Navigator: IFNA1 (8 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/4085 PubMed articles for IFNA1 gene (see all 4085 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 3439 HGNC: 5417 AceView: IFNA1 Ensembl:ENSG00000197919 euGenes: HUgn3439
    ECgene: IFNA1 H-InvDB: IFNA1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for IFNA1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ifna1/
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for IFNA1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for IFNA1 Antibodies for IFNA1
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     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for IFNA1

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