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Aliases & Descriptions for IFNA1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| IFL 1, 2 | | IFN 1, 2 | | IFN-ALPHA 1, 2 | | IFNA13 1, 2 | | IFNA@ 1, 2, 5 | | MGC138207 2 | | MGC138505 2 | | MGC138507 2 | | OTTHUMP00000045110 2 |
| | | Descriptions |
|---|
| IFN-alpha 1b 2 | | Interferon alpha-D 3 | | LeIF D 3 | | interferon alpha 1b 2 | | interferon, alpha 1 2 |
|
| | Search outside databases for aliases for IFNA1 genePrevious GC identifers: GC09P021768 GC09P021641 |
Summaries for IFNA1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for IFNA1: Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma; MIM 147570) is produced by mitogen- or antigen-stimulated T lymphocytes.[supplied by OMIM] UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetaseGene Wiki entry for IFNA1 (Interferon%2C_alpha_1) |
Genomic Location for IFNA1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the IFNA1 gene 
Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22IFNA1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P021430:
(about GC identifiers)
Start:
|
21,430,440 bp from pter |
End:
|
21,431,315 bp from pter |
Size:
|
876 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008413.17
| Proteins for IFNA1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562 (See
protein sequence)Recommended Name: Interferon alpha-1/13 precursor Size: 189 amino acids; 21725 Da
Subcellular location: Secreted
Miscellaneous: Interferons alpha-1 and alpha-13 have identical protein sequences
Secondary accessions: Q14605 Q2M1L8 Q52LB8 Q5VYQ2 Q7M4Q1 Q8WZ68 Q9UMJ3Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_076918.1
ENSEMBL proteins: ENSP00000276927
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for IFNA1: Assays for IFNA1: | Protein
Domains/ Families for IFNA1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P01562
ProtoNet protein and cluster: P01562 1 Blocks protein family: IPB000471 Interferon alpha
UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562Similarity: Belongs to the alpha/beta interferon family | Gene Function for IFNA1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024013
Applied Biosystems Silencer® siRNAs for IFNA1
Sigma-Aldrich siRNA and siRNA Panels for IFNA1  Sigma-Aldrich shRNA Panels and shRNA for IFNA1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024013                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024013                                  untagged cDNA clone in CMV expression vector: NM_024013 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024013
UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetaseGenatlas biochemistry entry for IFNA1:interferon type I,alpha 1,leukocyte | Pathways & Interactions for IFNA1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for IFNA1 (Your Favorite Gene powered by Ingenuity) (see all 9
) 
Gene Network CentralTM Interacting Genes and Proteins Network for IFNA1 
|
Drugs & Compounds for IFNA1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for IFNA1 10/28 Novoseek chemical compound relationships for IFNA1 gene (see all 28
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ifn-alpha |
94.81 |
1908 |
16142050 (22), 15389589 (13), 15581417 (12), 11505050 (12) (see all 99) |
| poly(i-c) |
73.09 |
56 |
1330423 (2), 8444700 (2), 12519390 (2), 17108037 (2) (see all 39) |
| neopterin |
61.90 |
64 |
16273760 (4), 8136311 (3), 14573318 (3), 15153315 (3) (see all 33) |
| resiquimod |
61.09 |
12 |
12470615 (3), 19183807 (1), 18342575 (1), 14638493 (1) (see all 8) |
| p113 |
61.07 |
5 |
7529187 (2), 8917387 (1), 8306959 (1), 8156998 (1) |
| indoleamine |
58.31 |
5 |
12466036 (1), 18776940 (1), 9712367 (1), 18950381 (1) (see all 5) |
| mnda |
54.06 |
7 |
7890814 (2), 11215814 (2), 14618084 (2) |
| tyrosine |
50.87 |
220 |
10803933 (6), 7532663 (5), 1385434 (5), 11682488 (4) (see all 99) |
| loxoribine |
50.46 |
2 |
17804388 (1), 17579574 (1), 17371961 (1) |
| rantes |
47.57 |
33 |
9491913 (3), 14679297 (2), 16940859 (2), 9247020 (1) (see all 29) |
About this table
|
Transcripts for IFNA1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024013
Sigma-Aldrich siRNA and siRNA Panels for IFNA1  Sigma-Aldrich shRNA Panels and shRNA for IFNA1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_024013 REFSEQ mRNAs for IFNA1 gene: NM_024013.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024013               OriGene GFP tagged cDNA clone in CMV expression vector: NM_024013                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024013                                  untagged cDNA clone in CMV expression vector: NM_024013  Additional cDNA sequence: BC074928.2 BC074929.2 BC112002.1 BC112300.1 BC112302.1 V00537.1 V00538.1 2 DOTS entries: DT.209454 DT.121155340 5 AceView cDNA sequences:BC074928 NM_024013 BC074929 V00537 V00538
highest scoring ESTs for IFNA1:BC074928 BC074929 BC112300 BC112302 J00210 V00537 V00538 NM_024013 BC112002 Unigene Cluster for IFNA1: Interferon, alpha 1 Hs.37026 Unigene Representative Sequence: NM_024013
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000276927
|
Expression for IFNA1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| IFNA1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for IFNA1
1 / 2 / 3 5 probe-sets matching IFNA1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.37026
Expression variation in blood from EXPOLDB for IFNA1 |
Orthologs for IFNA1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IFNA1 gene from 3 species
About this table Species with no ortholog for IFNA1
ENSEMBL Gene Tree for IFNA1 | Paralogs for IFNA1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for IFNA1 gene
- IFNA131 2 IFNA212 IFNA22 IFNA72 IFNA172 IFNA42 IFNA62 IFNA142
- IFNA162 IFNA102 IFNA82 IFNA52
|
SNPs/Variants for IFNA1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562Polymorphism: Two forms exist; alpha-1a (shown here) and alpha-1b
HapMap Linkage Disequilibrium images for IFNA1 (up to first 250kb)
|
Disorders & Mutations for IFNA1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 147660 10/96 Novoseek disease relationships for IFNA1 gene (see all 96
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hepatitis c chronic |
95.14 |
1659 |
10846411 (5), 9751011 (4), 15313671 (4), 12639294 (4) (see all 99) |
| hepatitis c |
90.42 |
812 |
9136611 (5), 9348307 (4), 9363321 (4), 11068424 (4) (see all 99) |
| myeloid leukemia chronic |
85.41 |
292 |
8249110 (2), 9362160 (2), 11236254 (2), 11865642 (2) (see all 99) |
| hepatitis b chronic |
85.18 |
393 |
11983129 (5), 16171525 (4), 16118673 (4), 10462338 (4) (see all 99) |
| virus infection |
82.61 |
451 |
11983129 (5), 8895920 (4), 17516539 (4), 9269299 (3) (see all 99) |
| hepatitis chronic |
82.55 |
162 |
12768394 (3), 9731580 (3), 1688684 (2), 7521417 (2) (see all 99) |
| metastatic renal cell carcinoma |
82.42 |
106 |
15852669 (2), 8647158 (2), 12778059 (2), 19047813 (2) (see all 92) |
| hepatitis chronic active |
78.57 |
105 |
9136611 (4), 8021761 (3), 16394599 (2), 7564784 (2) (see all 81) |
| cml chronic phase |
78.33 |
35 |
11042556 (2), 12973833 (2), 12620292 (1), 11369652 (1) (see all 30) |
| leukemia hairy cell |
77.46 |
58 |
9830322 (3), 9001417 (3), 1851909 (2), 1697012 (1) (see all 53) |
About this table
Genetic Association Database: IFNA1 Human Genome Epidemiology Navigator: IFNA1 (8 documents)
|
Medical News for IFNA1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for IFNA1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/4085 PubMed articles for IFNA1 gene (see all 4085
):- Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group. (PubMed id 11315919)1, 3, 6 Donn R.P....Thomson W. (2001)
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 2, 3 Olopade O.I....Diaz M.O. (1992)
- Association between IFNA genotype and the risk of systemic lupus erythematosus. (PubMed id 15674657)3, 6 Nakashima H....Harada M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)3, 4 Humphray S.J.... Dunham I. (2004)
- Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. (PubMed id 12761564)3, 6 Aucan C....Hill A.V. (2003)
- IFN-alpha-1a gene is the major variant in the North American population. (PubMed id 11032395)3, 4 Hussain M.... Liao M.-J. (2000)
- Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)3, 4 Nyman T.A.... Kalkkinen N. (1998)
- Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides. (PubMed id 2985969)3, 4 Capon D.J.... Goeddel D.V. (1985)
- Structural relationship of human interferon alpha genes and pseudogenes. (PubMed id 4057246)3, 4 Henco K.... Weissmann C. (1985)
|
Search for IFNA1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IFNA1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing IFNA1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFNA1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for IFNA1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for IFNA1:

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| Antibodies & Assays for IFNA1  (IFN-alpha) |
| | | | Search Tocris compounds for IFNA1 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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