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IFNA1 Gene

protein-coding   GIFtS: 62
GCID: GC09P021430

Interferon, Alpha 1

  See IFNA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon, Alpha 11 2     IFL2
IFN-Alpha 1b1 2     IFN2
Interferon Alpha 1b1 2     IFN-ALPHA2
Interferon Alpha-D2 3     IFN-alphaD2
LeIF D2 3     IFNA132
IFN-alpha-1/132 3     Interferon Alpha-1/132
IFNA@2 5     interferon-alpha12

External Ids:    HGNC: 54171   Entrez Gene: 34392   Ensembl: ENSG000001979197   OMIM: 1476605   UniProtKB: P015623   

Export aliases for IFNA1 gene to outside databases

Previous GC identifers: GC09P021768 GC09P021641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IFNA1 Gene:
The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless
and the encoded protein is secreted. (provided by RefSeq, Sep 2011)

GeneCards Summary for IFNA1 Gene:
IFNA1 (interferon, alpha 1) is a protein-coding gene. Diseases associated with IFNA1 include granulomatous hepatitis, and oral erosive lichen. An important paralog of this gene is IFNA7.

UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
two enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA1 (Interferon, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IFNA1 gene promoter:
         c-Fos   STAT1   Sp1   AP-1   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIFNA1 promoter sequence
   Search Chromatin IP Primers for IFNA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IFNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

IFNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P021430:  view genomic region     (about GC identifiers)

Start:
21,440,440 bp from pter      End:
21,441,315 bp from pter
Size:
876 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562 (See protein sequence)
Recommended Name: Interferon alpha-1/13 precursor  
Size: 189 amino acids; 21725 Da
Miscellaneous: Interferons alpha-1 and alpha-13 have identical protein sequences
1 PDB 3D structure from and Proteopedia for IFNA1:
3UX9 (3D)    
Secondary accessions: D4Q9M8 Q14605 Q2M1L8 Q52LB8 Q5VYQ2 Q7M4Q1 Q8WZ68 Q9UMJ3

Explore the universe of human proteins at neXtProt for IFNA1: NX_P01562

Explore proteomics data for IFNA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IFNA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076918.1  
    ENSEMBL proteins: 
     ENSP00000276927  
    Reactome Protein details: P01562

    IFNA1 Human Recombinant Protein Products:

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    OriGene Purified Protein for IFNA1
    OriGene Protein Over-expression Lysate for IFNA1
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    GenScript Purified and Recombinant Proteins for IFNA1
    Novus Biologicals IFNA1 Proteins
    Novus Biologicals IFNA1 Lysates
    Sino Biological Recombinant Protein for IFNA1
    Sino Biological Cell Lysate for IFNA1
    ProSpec Recombinant Protein for IFNA1
    Browse Proteins at Cloud-Clone Corp.

     
    eBioscience Proteins for IFNA1:  
                        Recombinant Human IFN-alpha2c 16.5 ug

     
    antibodies-online proteins for IFNA1 (53 products) 

     
    antibodies-online peptides for IFNA1

    IFNA1 Antibody Products:

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    ThermoFisher Antibody for IFNA1
    antibodies-online antibodies for IFNA1 (149 products) 

    IFNA1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for IFNA1: (see all 6
                        Human anti-IFN-alpha Platinum ELISA 96 tests
    antibodies-online kits for IFNA1 (70 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFN: Interferons

    4 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR015589 Interferon_alpha
     IPR000471 Interferon_alpha/beta/delta
     IPR009079 4_helix_cytokine-like_core

    Graphical View of Domain Structure for InterPro Entry P01562

    ProtoNet protein and cluster: P01562

    1 Blocks protein domain: IPB000471 Interferon alpha

    UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562
    Similarity: Belongs to the alpha/beta interferon family


    Find genes that share domains with IFNA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IFNA1_HUMAN, P01562
    Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of
    two enzymes: a protein kinase and an oligoadenylate synthetase

         Genatlas biochemistry entry for IFNA1:
    interferon type I,alpha 1,leukocyte

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity ----
    GO:0005126cytokine receptor binding ----
    GO:0005132type I interferon receptor binding ----
         
    Find genes that share ontologies with IFNA1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IFNA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IFNA1:
    hsa-mir-122-5p (MIRT023373)

    Block miRNA regulation of human, mouse, rat IFNA1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate IFNA1:
    hsa-miR-577 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIFNA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IFNA1
    Predesigned siRNA for gene silencing in human, mouse, rat IFNA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IFNA1

    Clone
    Products:
         
    OriGene clones in human, mouse for IFNA1 (see all 6)
    OriGene ORF clones in mouse, rat for IFNA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IFNA1 (NM_024013)
    Sino Biological Human cDNA Clone for IFNA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IFNA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for IFNA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IFNA1_HUMAN, P01562: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    plasma membrane2
    cytoskeleton1
    cytosol1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space ----

    Find genes that share ontologies with IFNA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IFNA1 About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    2NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    NOD-like Receptor Signaling Pathways0.58
    3Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    Regulation of IFNA signaling0.69
    4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    5Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34


    Find genes that share SuperPaths with IFNA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IFNA1
        NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IFNA1
        Cytokine Network
    Interferon Pathway
    JAK-STAT Pathway
    all-trans-Retinoic Acid Mediated Apoptosis

    2 GeneGo (Thomson Reuters) Pathways for IFNA1
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response IFN alpha/beta signaling pathway

    2 BioSystems Pathways for IFNA1
        Toll-like receptor signaling pathway
    Regulation of toll-like receptor signaling pathway


    4 Reactome Pathways for IFNA1
        Regulation of IFNA signaling
    Interferon alpha/beta signaling
    Factors involved in megakaryocyte development and platelet production
    TRAF6 mediated IRF7 activation


    Selected Kegg Pathways  (Kegg details for IFNA1) (see all 15):
        Cytokine-cytokine receptor interaction
    Regulation of autophagy
    PI3K-Akt signaling pathway
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNA1 (see all 16): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IFNA1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for IFNA1 (P015623 ENSP000002769274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL2P605683, ENSP000002267304I2D: score=1 STRING: ENSP00000226730
    IRF9Q009783, ENSP000003800734I2D: score=1 STRING: ENSP00000380073
    CR2P200233, ENSP000003560244I2D: score=3 STRING: ENSP00000356024
    IFNAR1P171813, ENSP000002701394I2D: score=1 STRING: ENSP00000270139
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response ----
    GO:0007596blood coagulation ----
    GO:0019221cytokine-mediated signaling pathway ----
    GO:0045087innate immune response ----
    GO:0051607defense response to virus ----

    Find genes that share ontologies with IFNA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IFNA1

    Selected Novoseek inferred chemical compound relationships for IFNA1 gene (see all 128)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ifn-alpha 95 2125 16142050 (22), 15389589 (13), 15581417 (12), 11505050 (12) (see all 99)
    ribavirin 92.7 1832 9862245 (8), 11233844 (7), 14586901 (6), 10438811 (6) (see all 99)
    2',5'-oligoadenylate 88.7 197 7648430 (5), 1723088 (4), 9260891 (3), 1379287 (3) (see all 99)
    polyinosinic-polycytidylic acid 77.1 57 11786977 (7), 2153928 (3), 2177082 (3), 9920723 (3) (see all 33)
    poly(i-c) 73 57 1330423 (2), 8444700 (2), 12519390 (2), 17108037 (2) (see all 40)
    hydroxyurea 72.5 306 7994025 (6), 11798827 (5), 8652857 (4), 14635203 (4) (see all 99)
    alanine 72.2 151 1279945 (2), 8228388 (1), 8790560 (1), 8816142 (1) (see all 99)
    lamivudine 70.6 368 16904047 (7), 10861649 (6), 11526544 (5), 18307594 (5) (see all 99)
    5fluorouracil 67 945 17699726 (8), 9463483 (8), 17275163 (8), 7646900 (7) (see all 99)
    dacarbazine 66.4 66 10359134 (3), 9586887 (2), 17600290 (2), 7992096 (1) (see all 41)



    Find genes that share compounds with IFNA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IFNA1 gene: 
    NM_024013.2  

    Unigene Cluster for IFNA1:

    Interferon, alpha 1
    Hs.37026
    Unigene Representative Sequence: AB578885
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000276927(uc003zpd.2)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate IFNA1:
    hsa-miR-577 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIFNA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IFNA1
    Predesigned siRNA for gene silencing in human, mouse, rat IFNA1
    Clone
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    OriGene clones in human, mouse for IFNA1 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: IFNA1 (NM_024013)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IFNA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA1
    Primer
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    OriGene qPCR primer pairs and template standards for IFNA1
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFNA1
      QuantiTect SYBR Green Assays in human, mouse, rat IFNA1
      QuantiFast Probe-based Assays in human, mouse, rat IFNA1

    Additional mRNA sequence: 

    AB578885.1 AB578886.1 BC074928.2 BC074929.2 BC112002.1 BC112300.1 BC112302.1 JN848523.1 
    V00537.1 V00538.1 

    2 DOTS entries:

    DT.209454  DT.121155340 

    5 AceView cDNA sequences:

    NM_024013 BC074928 BC074929 V00538 V00537 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IFNA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IFNA1 Expression
    About this image

    IFNA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IFNA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37026
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IFNA1 (see all 16): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IFNA1
    OriGene qSTAR qPCR primer pairs in human, mouse for IFNA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IFNA1
    QuantiTect SYBR Green Assays in human, mouse, rat IFNA1
    QuantiFast Probe-based Assays in human, mouse, rat IFNA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IFNA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IFNA1 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm125975 predicted gene 12597   --   4 (41.96 cM) 88557673 


    ENSEMBL Gene Tree for IFNA1 (if available)
    TreeFam Gene Tree for IFNA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IFNA1 gene
    IFNA131 2  IFNA72  IFNA22  IFNA42  IFNE2  IFNA142  IFNA52  IFNK2  
    IFNA212  IFNA172  IFNA62  IFNB12  IFNW12  IFNA162  IFNA102  IFNA82  
    18 SIMAP similar genes for IFNA1 using alignment to 2 protein entries:     IFNA1_HUMAN (see all proteins):
    IFNA13    IFNA5    IFNA10    IFNA14    IFNA17    IFNA21
    IFNA4    IFNA6    IFNA7    IFN-2    IFNA    IFNA2
    IFNA2B    IFNA16    IFNA8    IFNW1    IFNE    IFNB1

    Find genes that share paralogs with IFNA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    IFNA1_HUMAN, P01562: Two forms exist; alpha-1a (shown here) and alpha-1b


    Selected SNPs for IFNA1 (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1484947511,2
    --21438555(+) ATGGAA/GCACTT 1 -- us2k10--------
    rs1158424841,2
    F--21438581(+) CCTGTC/GAGGTT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs13321901,2
    C,F,O,A,H--21438684(-) TCCATC/TGTCTA 1 -- us2k135Minor allele frequency- N:0.00NS EA NA WA CSA 3169
    rs1876842261,2
    --21438709(+) TTTCTA/GCTTTC 1 -- us2k10--------
    rs109649941,2
    C,F,H--21438720(+) ATGTAG/ACCTCT 1 -- us2k1 tfbs33Minor allele frequency- A:0.03NS NA 174
    rs2011480171,2
    --21438880(+) GCCCC-/TTTTTT 1 -- us2k10--------
    rs18315831,2
    C,F--21439076(+) TTTATA/CTACCT 1 -- us2k18Minor allele frequency- C:0.09NA NS EA 314
    rs1925564921,2
    --21439160(+) TATGAC/TTTTTA 1 -- us2k10--------
    rs2016935121,2
    --21439171(+) ATCTT-/TTATTGTG 1 -- us2k10--------
    rs1840741741,2
    --21439249(+) TCAAGC/TTTGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IFNA1 (21440440 - 21441315 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IFNA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv892724CNV Gain21882294
    nsv466297CNV Gain19166990
    nsv892739CNV Gain21882294
    esv2752289CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147660    OMIM disorders: --

    Selected diseases for IFNA1 (see all 35):    
    About MalaCards
    granulomatous hepatitis    oral erosive lichen    cryoglobulinemic vasculitis    lymphomatoid granulomatosis
    htlv-1 associated myelopathy    hymenolepiasis    cd40 deficiency    superficial basal cell carcinoma
    engraftment syndrome    panuveitis    kimura disease    eastern equine encephalitis
    pernicious anemia    discoid lupus erythematosus    bell's palsy    hepatitis d
    borna disease    autoimmune thrombocytopenic purpura    severe hemophilia a    subacute cutaneous lupus erythematosus

    Selected diseases from the University of Copenhagen DISEASES database for IFNA1 (see all 23):
    Hepatitis C     Hepatitis     Hepatitis B     Renal cell carcinoma
    Leukemia     Melanoma     Hypersensitivity reaction type II disease     Liver cirrhosis
    Leukopenia     Myeloma     Hepatocellular carcinoma     Connective tissue disease
    Cryoglobulinemia     Lymphoma     Acquired immunodeficiency syndrome     Influenza
    Thrombocytopenia     Colorectal cancer     Skin disease     Kaposi's sarcoma

    Find genes that share disorders with IFNA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IFNA1 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c chronic 95.1 1710 10846411 (5), 9751011 (4), 15313671 (4), 12639294 (4) (see all 99)
    hepatitis c 90.5 867 9136611 (5), 9348307 (4), 9363321 (4), 11068424 (4) (see all 99)
    hepatitis b chronic 85.1 414 11983129 (5), 16171525 (4), 16118673 (4), 10462338 (4) (see all 99)
    myeloid leukemia chronic 85 293 8249110 (2), 9362160 (2), 11236254 (2), 11865642 (2) (see all 99)
    metastatic renal cell carcinoma 83.6 124 15852669 (2), 8647158 (2), 12778059 (2), 19047813 (2) (see all 99)
    virus infection 83.1 475 11983129 (5), 8895920 (4), 17516539 (4), 9269299 (3) (see all 99)
    hepatitis chronic 82.2 163 12768394 (3), 9731580 (3), 1688684 (2), 7521417 (2) (see all 99)
    hepatitis chronic active 78.6 109 9136611 (4), 8021761 (3), 16394599 (2), 7564784 (2) (see all 82)
    cml chronic phase 77.5 35 11042556 (2), 12973833 (2), 12620292 (1), 11369652 (1) (see all 30)
    leukemia hairy cell 77.2 58 9830322 (3), 9001417 (3), 1851909 (2), 1697012 (1) (see all 53)

    Genetic Association Database (GAD): IFNA1
    Human Genome Epidemiology (HuGE) Navigator: IFNA1 (23 documents)

    Export disorders for IFNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IFNA1 gene, integrated from 10 sources (see all 5286):
    (articles sorted by number of sources associating them with IFNA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic association of interferon-alpha subtypes 1, 2 and 5 in systemic lupus erythematosus. (PubMed id 19000144)1, 4, 9 Hirankarn N....Avihingsanon Y. (Tissue Antigens 2008)
    2. Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group. (PubMed id 11315919)1, 4, 9 Donn R.P....Thomson W. (Arthritis Rheum. 2001)
    3. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)1, 3, 9 Olopade O.I....Diaz M.O. (Genomics 1992)
    4. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (Fam. Cancer 2010)
    5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    6. Cytokine gene polymorphisms in irritable bowel syndrome in Indian population--a pilot case control study. (PubMed id 20860222)1, 4 Santhosh S....Kurian G. (Trop Gastroenterol 2010)
    7. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. The IFN-gamma allele is correlated to moderate-to-severe acute graft-versus-host disease after allogeneic stem cell transplant. (PubMed id 20565368)1, 4 Karimi M.H....Ebadi P. (Exp Clin Transplant 2010)
    10. Novel cis-active structures in the coding region mediate CRM1- dependent nuclear export of IFN-alpha 1 mRNA. (PubMed id 20857263)1, 2 Kimura T.... Yamada H. (Med. Mol. Morphol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3439 HGNC: 5417 AceView: IFNA1 Ensembl:ENSG00000197919 euGenes: HUgn3439
    ECgene: IFNA1 Kegg: 3439 H-InvDB: IFNA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IFNA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IFNA1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ifna1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IFNA1 gene:
    Search GeneIP for patents involving IFNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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